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https://www.readbyqxmd.com/read/29770919/dl-propargylglycine-protects-against-myocardial-injury-induced-by-chronic-intermittent-hypoxia-through-inhibition-of-endoplasmic-reticulum-stress
#1
Xiufang Zhou, Si Tang, Ke Hu, Zhan Zhang, Pei Liu, Yuchuan Luo, Jing Kang, Lifang Xu
BACKGROUND: Chronic intermittent hypoxia (CIH), an important basis of the pathogenesis of organ damage induced by obstructive sleep apnea syndrome (OSAS), is associated with myocardial injury, such as left ventricular dysfunction, apoptosis, and oxidative stress. Endogenous hydrogen sulfide (H2 S) plays an important role in maintaining cardiovascular functions. Many studies have demonstrated that exogenous H2 S has protective effects against myocardial injury induced by various cardiovascular diseases, and inhibiting the generation of endogenous H2 S has opposite effects...
May 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29766271/obstructive-sleep-apnea-and-cerebral-white-matter-change-a-systematic-review-and-meta-analysis
#2
Bo-Lin Ho, Ping-Tao Tseng, Chiou-Lian Lai, Meng-Ni Wu, Ming-Ju Tsai, Cheng-Fang Hsieh, Tien-Yu Chen, Chung-Yao Hsu
Obstructive sleep apnea (OSA) can cause sleep fragmentation and intermittent hypoxemia, which are linked to oxidative stress. White matter changes (WMCs) representing cerebrovascular burden and are at risk factor for oxidative ischemic injury. The current study explores the mutual relationships between OSA and WMCs. We performed a systematic review of electronic databases for clinical studies investigating OSA and WMCs. Random-effects models were used for pooled estimates calculation. A total of 22 studies were included in the meta-analysis...
May 15, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29758366/curcumin-attenuates-chronic-intermittent-hypoxia-induced-brain-injuries-by-inhibiting-aqp4-and-p38-mapk-pathway
#3
Bo Wang, Wenyang Li, Hongyu Jin, Xinshi Nie, Hui Shen, Erran Li, Wei Wang
Chronic intermittent hypoxia (CIH) is one of the main features of obstructive sleep apnea (OSA), which is also commonly associated with neurocognitive impairments. The present study aimed to elucidate the beneficial effect of curcumin on CIH-induced brain injuries. Male balb/c mice (6 ∼ 8 weeks) were exposed to normoxia or a pattern of CIH (8 h/day, cycles of 180 sec each, hypoxia: 5% O2 for 50 sec, reoxygenation: 21% O2 for 50 sec) for 10 weeks, along with daily curcumin treatment (50, 100, or 200 mg/kg, intragastrically) or its vehicle...
May 11, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29749715/altered-resting-state-hippocampal-and-caudate-functional-networks-in-patients-with-obstructive-sleep-apnea
#4
Xiaopeng Song, Bhaswati Roy, Daniel W Kang, Ravi S Aysola, Paul M Macey, Mary A Woo, Frisca L Yan-Go, Ronald M Harper, Rajesh Kumar
INTRODUCTION: Brain structural injury and metabolic deficits in the hippocampus and caudate nuclei may contribute to cognitive and emotional deficits found in obstructive sleep apnea (OSA) patients. If such contributions exist, resting-state interactions of these subcortical sites with cortical areas mediating affective symptoms and cognition should be disturbed. Our aim was to examine resting-state functional connectivity (FC) of the hippocampus and caudate to other brain areas in OSA relative to control subjects, and to relate these changes to mood and neuropsychological scores...
May 10, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29735608/diagnostic-accuracy-of-a-two-stage-model-for-detecting-obstructive-sleep-apnoea-in-chronic-tetraplegia
#5
Marnie Graco, Rachel Schembri, Susan Cross, Chinnaya Thiyagarajan, Shirin Shafazand, Najib T Ayas, Mark S Nash, Viet H Vu, Warren R Ruehland, Ching Li Chai-Coetzer, Peter Rochford, Thomas Churchward, Sally E Green, David J Berlowitz
BACKGROUND: Obstructive sleep apnoea (OSA) is highly prevalent in people with spinal cord injury (SCI). Polysomnography (PSG) is the gold-standard diagnostic test for OSA, however PSG is expensive and frequently inaccessible, especially in SCI. A two-stage model, incorporating a questionnaire followed by oximetry, has been found to accurately detect moderate to severe OSA (MS-OSA) in a non-disabled primary care population. This study investigated the accuracy of the two-stage model in chronic tetraplegia using both the original model and a modified version for tetraplegia...
May 7, 2018: Thorax
https://www.readbyqxmd.com/read/29725493/intermittent-hypoxia-increases-the-severity-of-bleomycin-induced-lung-injury-in-mice
#6
Thomas Gille, Morgane Didier, Cécile Rotenberg, Eva Delbrel, Dominique Marchant, Angela Sutton, Nicolas Dard, Liasmine Haine, Nicolas Voituron, Jean-François Bernaudin, Dominique Valeyre, Hilario Nunes, Valérie Besnard, Emilie Boncoeur, Carole Planès
Background: Severe obstructive sleep apnea (OSA) with chronic intermittent hypoxia (IH) is common in idiopathic pulmonary fibrosis (IPF). Here, we evaluated the impact of IH on bleomycin- (BLM-) induced pulmonary fibrosis in mice. Methods: C57BL/6J mice received intratracheal BLM or saline and were exposed to IH (40 cycles/hour; FiO2 nadir: 6%; 8 hours/day) or intermittent air (IA). In the four experimental groups, we evaluated (i) survival; (ii) alveolar inflammation, pulmonary edema, lung oxidative stress, and antioxidant enzymes; (iii) lung cell apoptosis; and (iv) pulmonary fibrosis...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29675617/is-acute-pulmonary-embolism-more-severe-in-the-presence-of-obstructive-sleep-apnea-results-from-an-observational-cohort-study
#7
Dinah Konnerth, Florian Schwarz, Michael Probst, Martin Seidler, Tanja Wagner, Christian Faul, Wolfgang von Scheidt, Martin Schwaiblmair, Thomas M Berghaus
Obstructive sleep apnea (OSA) might influence disease severity in acute pulmonary embolism (PE). 253 survivors of acute PE were evaluated for sleep-disordered breathing by portable monitoring and nocturnal polysomnography. PE patients with an apnea-hypopnoea index (AHI) ≥ 15/h were significantly older (p < 0.001), had significantly impaired renal (p < 0.001) and left ventricular functions (p = 0.003), showed significantly elevated troponin I (p = 0.005) and D-dimer levels (p = 0...
April 19, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29658103/genioglossus-reflex-responses-to-negative-upper-airway-pressure-are-altered-in-people-with-tetraplegia-and-obstructive-sleep-apnoea
#8
Nirupama S Wijesuriya, Laura Gainche, Amy S Jordan, David J Berlowitz, Mariannick LeGuen, Peter D Rochford, Fergal J O'Donoghue, Warren R Ruehland, Jayne C Carberry, Jane E Butler, Danny J Eckert
More than 60% of people with tetraplegia have obstructive sleep apnoea (OSA). However, the specific causes are unknown. Genioglossus, the largest upper-airway dilator muscle, is important in maintaining upper-airway patency. Impaired genioglossus muscle function following spinal cord injury may contribute to OSA. This study aimed to determine if genioglossus reflex responses to negative upper-airway pressure are altered in people with OSA and tetraplegia compared to non-neurologically impaired able-bodied individuals with OSA...
April 15, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29619250/relationship-between-autonomic-cardiovascular-control-and-obstructive-sleep-apnoea-in-persons-with-spinal-cord-injury-a-retrospective-study
#9
Xizhe Fang, Min Yin Goh, Christopher O'Callaghan, David Berlowitz
Study design: Retrospective study. Objective: To determine if there is an association between obstructive sleep apnoea (OSA) and blood pressure (BP) pattern or heart rate variability (HRV) in people with spinal cord injury (SCI). Setting: A state-based spinal cord service in Victoria, Australia. Methods: We identified 42 subjects who had ambulatory BP monitoring (ABPM) within 6 months of a diagnostic sleep study at Austin Hospital between 2009 and 2014...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29550481/protective-effect-of-sphingosine-1-phosphate-for-chronic-intermittent-hypoxia-induced-endothelial-cell-injury
#10
Fu-Chao Yu, Chu-Xiao Yuan, Jia-Yi Tong, Guang-Hao Zhang, Fang-Ping Zhou, Fang Yang
Intermittent hypoxia (IH) induced by obstructive sleep apnea (OSA) is the key factor in oxidative stress and the concomitant inflammation of endothelial cells (ECs). In recent years, the lipid sphingosine-1-phosphate (S1P) has been reported to probably play a central role in inflammatory diseases. However, its role in IH-induced endothelial injury remains uncertain. In this study, we investigated the IH-induced ECs inflammation and apoptosis, as well as the role of S1P in both. First, human umbilical vein endothelial cells (HUVECs) were treated with IH to explore the mechanism of S1P and S1P microbubbles (S1P-MBs) in HUVECs with altered function...
April 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29515212/positive-airway-pressure-therapy-for-sleep-disordered-breathing-confers-short-term-benefits-to-patients-with-spinal-cord-injury-despite-widely-ranging-patterns-of-use
#11
Jeanette P Brown, Kristy A Bauman, Armando Kurili, Gianna M Rodriguez, Anthony E Chiodo, Robert G Sitrin, Helena M Schotland
STUDY DESIGN: Prospective, cohort study. OBJECTIVES: To evaluate the effectiveness of bi-level positive airway pressure (PAP) therapy and the patterns of use for sleep-disordered breathing (SDB) in individuals with spinal cord injury (SCI). SETTING: Academic tertiary care center, USA. METHODS: Overall, 91 adults with C1-T6 SCI for ≥3 months were recruited and 74 remained in the study to be evaluated for SDB and follow-up...
March 7, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29512942/haemin-attenuates-intermittent-hypoxia-induced-cardiac-injury-via-inhibiting-mitochondrial-fission
#12
Qian Han, Guihua Li, Mary SiuMan Ip, Yuelin Zhang, Zhe Zhen, Judith ChoiWo Mak, Nuofu Zhang
Obstructive sleep apnoea (OSA) characterized by intermittent hypoxia (IH) is closely associated with cardiovascular diseases. IH confers cardiac injury via accelerating cardiomyocyte apoptosis, whereas the underlying mechanism has remained largely enigmatic. This study aimed to explore the potential mechanisms involved in the IH-induced cardiac damage performed with the IH-exposed cell and animal models and to investigate the protective effects of haemin, a potent haeme oxygenase-1 (HO-1) activator, on the cardiac injury induced by IH...
May 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29509806/obstructive-sleep-apnea-and-cortical-thickness-in-females-and-males
#13
Paul M Macey, Natasha Haris, Rajesh Kumar, M Albert Thomas, Mary A Woo, Ronald M Harper
INTRODUCTION: Obstructive sleep apnea (OSA) affects approximately 10% of adults, and alters brain gray and white matter. Psychological and physiological symptoms of the disorder are sex-specific, perhaps related to greater injury occurs in female than male patients in white matter. Our objective was to identify influences of OSA separated by sex on cortical gray matter. METHODS: We assessed cortical thickness in 48 mild-severe OSA patients (mean age±std[range] = 46...
2018: PloS One
https://www.readbyqxmd.com/read/29482817/elevated-tau-and-interleukin-6-concentrations-in-adults-with-obstructive-sleep-apnea
#14
Vida Motamedi, Rebekah Kanefsky, Panagiotis Matsangas, Sara Mithani, Andreas Jeromin, Matthew S Brock, Vincent Mysliwiec, Jessica Gill
Obstructive sleep apnea (OSA) is characterized by apneas and hypopneas that result in hypoxia, cerebral hypoperfusion, endothelial dysfunction, inflammation, and oxidative stress. These pathophysiologic processes likely contribute to neuronal damage. Tau is a protein that stabilizes microtubules and, along with amyloid beta (Aβ), is associated with neurodegenerative processes. We sought to determine if tau and other biomarkers of inflammation were related to OSA severity. Concentrations of tau, Aβ40, Aβ42, c-reactive protein (CRP), TNF-α, interleukin (IL)-6, and IL-10 were measured in blood and compared between participants with moderate-severe OSA (n = 28), those with mild OSA (n = 22), and healthy controls (n = 24)...
March 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29481438/research-needs-assessment-for-children-with-obstructive-sleep-apnea-undergoing-diagnostic-or-surgical-procedures
#15
Kimmo T Murto, Wesley Chen, Sherri L Katz, Deborah A Schwengel, Lisa M Elden, Kumar G Belani, David Gozal
Recent concerns have been raised about the quality and safety of adenotonsillectomy, a common surgery performed to treat obstructive sleep apnea (OSA) in children. OSA is a risk factor for opioid-related perioperative respiratory complications including those associated with anoxic brain injury or death. Our objective was to identify controversial issues related to the care of children with OSA. A standardized Delphi consensus technique involving an interdisciplinary group of 24 pediatric OSA experts identified 3 key issues: "postoperative disposition, preoperative screening, and pain management...
February 23, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29403430/altered-regional-brain-cortical-thickness-in-pediatric-obstructive-sleep-apnea
#16
Paul M Macey, Leila Kheirandish-Gozal, Janani P Prasad, Richard A Ma, Rajesh Kumar, Mona F Philby, David Gozal
Rationale: Obstructive sleep apnea (OSA) affects 2-5% of all children and is associated with cognitive and behavioral deficits, resulting in poor school performance. These psychological deficits may arise from brain injury, as seen in preliminary findings of lower gray matter volume among pediatric OSA patients. However, the psychological deficits in OSA are closely related to functions in the cortex, and such brain areas have not been specifically assessed. The objective was to determine whether cortical thickness, a marker of possible brain injury, is altered in children with OSA...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29389945/intermittent-hypoxia-causes-histological-kidney-damage-and-increases-growth-factor-expression-in-a-mouse-model-of-obstructive-sleep-apnea
#17
Bisher Abuyassin, Mohammad Badran, Najib T Ayas, Ismail Laher
Epidemiological studies demonstrate an association between obstructive sleep apnea (OSA) and accelerated loss of kidney function. It is unclear whether the decline in function is due to OSA per se or to other confounding factors such as obesity. In addition, the structural kidney abnormalities associated with OSA are unclear. The objective of this study was to determine whether intermittent hypoxia (IH), a key pathological feature of OSA, induces renal histopathological damage using a mouse model. Ten 8-week old wild-type male CB57BL/6 mice were randomly assigned to receive either IH or intermittent air (IA) for 60 days...
2018: PloS One
https://www.readbyqxmd.com/read/29224042/association-between-continuous-positive-airway-pressure-and-serum-aminotransferases-in-patients-with-obstructive-sleep-apnea
#18
Li-Da Chen, Liang-Ji Zhang, Xue-Jun Lin, Jia-Chao Qi, Hao Li, Zhi Wu, Qiao-Zhen Xu, Ya-Ping Huang, Li Lin
INTRODUCTION: Obstructive sleep apnea (OSA) has been suggested to be a potential contributing factor for nonalcoholic fatty liver disease (NAFLD). Studies on the association between continuous positive airway pressure (CPAP) and NAFLD in OSA patients are limited and controversial. OBJECTIVES: The aim of this study was to assess the relationship between OSA and NAFLD and the effect of CPAP therapy on serum aminotransferase levels in OSA patients. METHODS: A total of 160 consecutive patients who underwent standard polysomnography were enrolled...
February 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29172922/thiol-disulfide-homeostasis-in-pregnant-women-with-obstructive-sleep-apnea-syndrome
#19
Yasemin Üstündağ, Hakan Demirci, Rifat Balık, Ozcan Erel, Fahri Özaydın, Bilgen Kücük, Dilber Ertaş, Emin Ustunyurt
BACKGROUND: Repetitive episodes of hypoxia and reoxygenation during sleep in patients with obstructive sleep apnea syndrome (OSAS) resemble an ischemia-reperfusion injury. We aimed to test the hypothesis that oxidative stress occurs in pregnant women with OSAS. We also aimed to compare thiol/disulfide homeostasis with ischemia-modified albumin (IMA) and total antioxidant capacity (TAC) as markers of ischemia-reperfusion injury in pregnant women with and without OSAS and healthy control...
November 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29157592/the-effects-of-continuous-positive-airway-pressure-therapy-on-troponin-t-and-n-terminal-pro-b-type-natriuretic-peptide-in-patients-with-obstructive-sleep-apnoea-a-randomised-controlled-trial
#20
Ya-Shu Chang, Brendon J Yee, Camilla M Hoyos, Keith K Wong, David R Sullivan, Ronald R Grunstein, Craig L Phillips
INTRODUCTION: Untreated obstructive sleep apnoea (OSA) is associated with increased risk of coronary artery disease (CAD) and heart failure. High-sensitivity cardiac troponin (hs Trop-T) and B-type natriuretic peptide (NT-pro-BNP) are sensitive biomarkers for myocardial injury and heart failure respectively. No randomised controlled trials have examined the treatment effect of continuous positive airway pressure (CPAP) in patients with OSA on these biomarkers. METHOD: Patients >21 years old with apnoea-hypopnoea index (AHI) ≥25/h by overnight polysomnography were recruited...
November 2017: Sleep Medicine
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