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Salivary duct carcinoma

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https://www.readbyqxmd.com/read/29897400/tailoring-treatment-of-salivary-duct-carcinoma-sdc-by-liquid-biopsy-arv7-expression-in-circulating-tumor-cells
#1
V Cappelletti, P Miodini, C Reduzzi, S Alfieri, M Grazia Daidone, L Licitra, L D Locati
No abstract text is available yet for this article.
April 20, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29867432/second-line-treatment-of-her2-positive-salivary-gland-tumor-ado-trastuzumab-emtansine-t-dm1-after-progression-on-trastuzumab
#2
Tatiana Strava Corrêa, Gustavo Duarte Ramos Matos, Marcos Segura, Carlos Henrique Dos Anjos
Patients with salivary duct cancer (SDC) and HER2 overexpression could receive trastuzumab in combination with chemotherapy for metastatic disease. No standard treatment exists for patients with HER2-positive metastatic SDC after progression. We report an excellent patient response to second-line treatment with T-DM1 after progression on paclitaxel plus trastuzumab. Case Report: In June 2014, a 79-year-old male patient underwent right parotidectomy and ipsilateral radical neck dissection after the diagnosis of parotid carcinoma...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29863801/androgen-receptor-in-salivary-gland-carcinoma-a-review-of-an-old-marker-as-a-possible-new-target
#3
Chit Cheng Yeoh, Nedal Dabab, Elyse Rigby, Ritu Chhikara, Iolia Akaev, Ricardo Santiago Gomez, Felipe Fonseca, Peter A Brennan, Siavash Rahimi
The role of the Androgen Receptor (AR) as an immunomarker for diagnosis of salivary gland duct carcinoma (SDC) is well known. Other non-squamous cell head and neck cancers (NSCC-HN), including a small subset of salivary gland cancers (SGCs), can also express AR. With the increase of effective and powerful new generation of anti-androgen agents and drugs administered orally, more targetable AR driven NSCC-HN, such as subsets of SGCs, should be investigated for possible expression of AR. In this review, we focus on SGC sub-types, which could express AR and describe the main androgen deprivation therapy (ADT) strategies...
June 4, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29805635/epigenetic-inactivation-of-galanin-receptors-in-salivary-duct-carcinoma-of-the-parotid-gland-potential-utility-as-biomarkers-for-prognosis
#4
Takeharu Kanazawa, Kiyoshi Misawa, Hirofumi Fukushima, Yuki Misawa, Yukiko Sato, Mikiko Maruta, Shoichiro Imayoshi, Gen Kusaka, Kazuyoshi Kawabata, Hiroyuki Mineta, Thomas E Carey, Hiroshi Nishino
Salivary duct carcinoma (SDC) constitutes one of the most aggressive cancers in the salivary gland and is associated with a poor prognosis; however, no established systemic therapy options are available. SDC exhibits biological similarity to prostate and breast cancers, therefore anti-hormone therapy and molecular target therapies are available, however with limited beneficial effects. Galanin and galanin receptors (GALRs) are well established as molecular biomarkers to predict the survival rate and risk of recurrence of head and neck squamous cell carcinoma...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29798259/-minor-salivary-duct-carcinoma-of-the-larynx-a-case-report
#5
J X Jia, Y H Liu, J B Zhang, L L Qu
Salivary duct carcinoma SDC is a rare disease, especially in the larynx. From the pathology point of view, SDC histomorphology is very similar to breast ductal carcinoma. From the immunohistochemistry, epithelial antibodies are positive, but the SMA is negative. From the review of papers, total resection is the first choice for the treatment, but the local recurrence and distant metastasis are the main influence factors for survival rate. Now we still lack the clinical experience for such disease.
July 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29785551/salivary-duct-carcinoma-evaluation-of-treatment-and-outcome-in-a-tertiary-referral-institute
#6
Ann-Jean C C Beck, Peter J F M Lohuis, Abrahim Al-Mamgani, Laura A Smit, Willem M C Klop
PURPOSE: The aggressive behavior of salivary duct carcinoma (SDC) necessitates an aggressive treatment strategy, including surgery and radiotherapy (RT). We evaluated practice patterns and treatment outcomes in patients with SDC treated in our Institute. METHODS: Patients with SDC of the parotid or submandibular gland treated with curative intention in our Institute from 1998 until 2016 were reviewed. Our diagnostic workup and treatment strategy were evaluated together with treatment outcomes...
May 21, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29753009/the-implications-of-trka-and-met-aberrations-in-de-novo-salivary-duct-carcinoma
#7
Hyang Joo Ryu, Yoon Woo Koh, Sun Och Yoon
Salivary duct carcinoma (SDC) is an aggressive carcinoma with poor prognosis. Although anti-HER2 therapy is a potential treatment option for HER2-positive SDC, other potential therapeutic targets are not known, in particular for HER2-negative cases. In this study, the recently identified receptor tyrosine kinases MET and tropomyosin-receptor kinase (Trk) were investigated as potential therapeutic targets. A total of 28 consecutive, surgically resected, de novo SDC cases were selected after evaluating histology and immunohistochemical expression of androgen receptor...
May 9, 2018: Human Pathology
https://www.readbyqxmd.com/read/29719073/the-expression-of-programed-death-ligand-1-could-be-related-with-unfavorable-prognosis-in-salivary-duct-carcinoma
#8
Fumihiko Sato, Jun Akiba, Akihiko Kawahara, Yoshiki Naito, Takeharu Ono, Yorihiko Takase, Kazuya Murata, Hideyuki Abe, Tomohiko Yamaguchi, Hiroaki Miyoshi, Yushi Abe, Yutaro Mihara, Masahiko Tanikawa, Momoko Akashi, Hirofumi Kurose, Hirohito Umeno, Hirohisa Yano
BACKGROUND: Salivary duct carcinoma (SDC) is a rare tumor occurring in the salivary gland. SDC is a highly aggressive tumor and its prognosis is extremely poor. Effective treatments in advanced SDC have not yet been established. Recently, immune checkpoint inhibitors have paved the way for the treatment of various malignancies. We examined the expressions of programed death ligand (PD-L) 1/PD-L2 and programed death (PD-1), and the correlation of clinicopathological findings. METHODS: We examined 18 cases of SDC and conducted immunohistochemical staining using formalin-fixed paraffin-embedded full-face sections...
May 2, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29671211/characterisation-of-dog-1-expression-in-salivary-gland-tumours-and-comparison-with-myoepithelial-markers
#9
Syed A Khurram, Paul M Speight
DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. However, its specificity and distribution is not well established. The aim of this study was to evaluate the diagnostic utility of DOG-1 expression in SGT in addition to comparing it with myoepithelial markers. Normal salivary tissue and SGT (n = 184) were examined for expression of DOG1 and a range of myoepithelial markers...
April 18, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29544756/cervical-lymph-node-metastatic-status-and-adjuvant-therapy-predict-the-prognosis-of-salivary-duct-carcinoma
#10
Kai Qian, Lu Di, Kai Guo, Xiaoke Zheng, Qinghai Ji, Zhuoying Wang
PURPOSE: Salivary duct carcinoma (SDC) is an aggressive malignancy that is not yet fully understood. We designed the present retrospective study to investigate the factors affecting the prognosis of SDC and the effects of adjuvant therapies on the clinical outcomes of patients. MATERIALS AND METHODS: Patients with SDC treated surgically from 2006 to 2016 were enrolled in the present retrospective cohort study. The demographic data, clinical pathologic characteristics, and follow-up results were recorded...
February 19, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29538201/salivary-duct-carcinoma-of-the-supraglottis-with-a-distinct-presentation-a-case-report-and-literature-review
#11
Cheng-Chieh Hsu, Wing-Yin Li, Pen-Yuan Chu
RATIONALE: Salivary duct carcinoma (SDC) is a rare and aggressive subtype of salivary gland carcinoma that histologically resembles in situ and invasive ductal carcinoma of the breast. We present the first case of advanced SDC of the minor salivary gland arising from the supraglottis and review the literature on the clinicopathologic characteristics and prognosis of SDC. PATIENT CONCERNS: A 59-year-old male patient with progressive difficulty in swallowing and a muffled voice for 2 months...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29533281/a-case-of-a-malignant-cutaneous-mixed-tumor-chondroid-syringoma-of-the-scapula-treated-with-staged-margin-controlled-excision
#12
Karan Lal, Travis J Morrell, Michael Cunningham, Patrick OʼDonnell, Nikki A Levin, Kristine M Cornejo
Cutaneous mixed tumor (chondroid syringoma) is the cutaneous counterpart of pleomorphic adenoma of salivary glands, comprised of both epithelial and mesenchymal components. Malignant transformation is exceptionally rare, with only a few cases reported. We report a case of a malignant cutaneous mixed tumor in an 86-year-old white man who presented with a pink indurated plaque on his left scapula. He had a history of nonmelanoma skin cancers, a stage IB malignant melanoma of a lower extremity and Gleason 4 + 3 prostate cancer treated with brachytherapy, external beam irradiation, and bicalutamide...
March 6, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29503943/androgen-receptor-positive-ductal-adenocarcinoma-of-the-nasolacrimal-duct-a-case-report
#13
In Ah Park, Ho-Seok Sa, Yoo-Sam Chung, Kyung-Ja Cho
Purpose: Primary ductal adenocarcinoma arising in the structures of the lacrimal apparatus is extremely rare, and the entity is considered a lacrimal counterpart of salivary duct carcinoma, of which the majority are known to express androgen receptor (AR). Less than 10 cases of AR-positive carcinomas of lacrimal gland or lacrimal sac have been described. Observations: We present a primary ductal adenocarcinoma with AR expression involving the nasolacrimal duct of a middle-aged patient who had suffered from right eyelid swelling, diplopia and epiphora for 4 months...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29494398/rank-and-rank-ligand-expression-in-parotid-gland-carcinomas
#14
Alessandro Franchi, Cecilia Taverna, Antonella Simoni, Monica Pepi, Giuditta Mannelli, Martina Fasolati, Oreste Gallo
Recently, it has been reported that deregulation of the receptor activator of NFkB ligand (RANKL)/RANK signaling axis results in salivary gland tumor development in a mouse transgenic model. The aim of this study was to ascertain RANKL and RANK protein expression in a series of primary parotid gland carcinomas and to correlate it with clinicopathologic parameters. Formalin-fixed paraffin-embedded tumor samples from 46 consecutive cases of parotid gland carcinoma were selected for this study. For comparison, we examined a group of 40 randomly chosen parotid gland adenomas, including 20 pleomorphic adenomas, 10 myoepitheliomas, and 10 Warthin tumors...
February 28, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29492965/a-clinicopathological-study-and-prognostic-factor-analysis-of-177-salivary-duct-carcinoma-patients-from-the-netherlands
#15
Eline Boon, Miranda Bel, Wim van Boxtel, Winette T A van der Graaf, Robert J J van Es, Simone E J Eerenstein, Robert J Baatenburg de Jong, Michiel W M van den Brekel, Lilly-Ann van der Velden, Max J H Witjes, Ann Hoeben, Stefan M Willems, Elisabeth Bloemena, Laura A Smit, Sjoukje F Oosting, Marianne A Jonker, Uta E Flucke, Carla M L van Herpen
Salivary duct carcinoma (SDC) is a subtype of salivary gland cancer with a dismal prognosis and a need for better prognostication and novel treatments. The aim of this national cohort study was to investigate clinical outcome, prognostic factors, androgen receptor (AR) and human epidermal growth factor receptor 2 (HER2) expression. SDC patients diagnosed between 1990 and 2014 were identified by the Nationwide Network and Registry of Histo- and Cytopathology in the Netherlands (PALGA). Subsequently, medical records were evaluated and pathological diagnoses reviewed...
March 1, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29473257/mixed-adenoneuroendocrine-carcinoma-of-the-tongue-arising-within-a-congenital-enteric-cyst
#16
Louis J Ligthelm, Belinda K Bunn, Erich J Raubenheimer, Willie F P van Heerden
BACKGROUND: Primary intestinal-type adenocarcinoma of the tongue is rare. This represents the first reported case of a primary mixed adenoneuroendocrine carcinoma (MANEC) of the tongue arising within a congenital enteric cyst. METHODS: A 52-year-old man presented with a midline tongue mass that was connected to the mucosal surface with an epithelial-lined sinus tract. Morphological examination and immunohistochemical profiling of the neoplasm were performed. RESULTS: Histopathological evaluation showed a primary MANEC arising within a preexisting congenital enteric cyst, comprising both adenocarcinoma and neuroendocrine components...
May 2018: Head & Neck
https://www.readbyqxmd.com/read/29465558/analysis-of-clinical-characteristics-and-treatment-of-immunoglobulin-g4-associated-cholangitis-a-retrospective-cohort-study-of-39-iac-patients
#17
Jianchun Xiao, Peiran Xu, Binglu Li, Tao Hong, Wei Liu, Xiaodong He, Chaoji Zheng, Yupei Zhao
Immunoglobulin (Ig)G4-associated cholangitis (IAC) is one of the common organ manifestations of IgG4-related systemic disease (ISD). IAC and autoimmune pancreatitis (AIP) may mimic sclerosing cholangitis, cholangiocarcinoma, or pancreatic carcinoma. Diagnosis is based on a combination of clinical, biochemical, radiological, and histological findings.To study the clinical presentation of and treatment strategy for IAC, we reviewed clinical, serologic, and imaging characteristics, as well as treatment response, in 39 patients with IAC...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443014/recurrent-ret-gene-rearrangements-in-intraductal-carcinomas-of-salivary-gland
#18
Ilan Weinreb, Justin A Bishop, Simion I Chiosea, Raja R Seethala, Bayardo Perez-Ordonez, Lei Zhang, Yun-Shao Sung, Chun-Liang Chen, Adel Assaad, Bahram R Oliai, Cristina R Antonescu
Intraductal carcinoma (IC) is the World Health Organization designation for lesions previously called low-grade cribriform cystadenocarcinoma. The relationship of IC to salivary duct carcinoma (SDC) is controversial, but currently these are considered distinct entities. It is hypothesized that IC and SDC should have different genomic signatures that may be identifiable by next-generation sequencing. A total of 23 ICs were identified: 14 pure IC and 9 invasive carcinomas with an intraductal component. Five invasive carcinomas were subjected to next-generation paired-end RNA sequencing...
April 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29422843/cutaneous-metastases-from-salivary-duct-carcinoma-of-the-submandibular-gland
#19
Wahida Chakari, Luise Andersen, Jørgen Lock Andersen
Salivary duct carcinoma is a rare and highly aggressive malignant neoplasm that frequently metastasises to other organs, but cutaneous metastasis is uncommon. There are only 6 cases reported in the literature with metastases to the skin and in all cases the tumour originates from the parotid gland. We present a case of skin metastases from the submandibular gland that was mistaken for basal cell carcinoma. To the best of our knowledge, this is the first reported case of salivary duct carcinoma arising from the submandibular gland with cutaneous metastases...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29416736/prognostic-and-histogenetic-roles-of-gene-alteration-and-the-expression-of-key-potentially-actionable-targets-in-salivary-duct-carcinomas
#20
Tomotaka Shimura, Yuichiro Tada, Hideaki Hirai, Daisuke Kawakita, Satoshi Kano, Kiyoaki Tsukahara, Akira Shimizu, Soichiro Takase, Yorihisa Imanishi, Hiroyuki Ozawa, Kenji Okami, Yuichiro Sato, Yukiko Sato, Chihiro Fushimi, Hideaki Takahashi, Takuro Okada, Hiroki Sato, Kuninori Otsuka, Yoshihiro Watanabe, Akihiro Sakai, Koji Ebisumoto, Takafumi Togashi, Yushi Ueki, Hisayuki Ota, Mizuo Ando, Shinji Kohsaka, Toyoyuki Hanazawa, Hideaki Chazono, Yoshiyuki Kadokura, Hitome Kobayashi, Toshitaka Nagao
The molecular characteristics of therapeutically-relevant targets and their clinicopathological implications in salivary duct carcinomas (SDCs) are poorly understood. We investigated the gene alterations and the immunoexpression of crucial oncogenic molecules in 151 SDCs. The mutation rates that were identified, in order of frequency, were as follows: TP53 , 68%; PIK3CA , 18%; H-RAS , 16%; BRAF , 4%; and AKT1 , 1.5%. PIK3CA/H-RAS/BRAF mutations were more common in de novo SDC than in SDC ex-pleomorphic adenoma...
January 5, 2018: Oncotarget
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