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Frozen sections

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https://www.readbyqxmd.com/read/28428910/role-of-the-interosseous-membrane-in-preventing-distal-radioulnar-gapping
#1
Frederick W Werner, Matthew R LeVasseur, Brian J Harley, Ashley Anderson
Background Damage to the interosseous membrane (IOM) can alter load transmission between the radius and ulna and decrease their axial stability. Less is known about the effect of IOM sectioning on the transverse stability between the radius and ulna. Purpose The purpose of this study was to quantify the radioulnar gapping at the distal radioulnar joint (DRUJ) during forearm rotation when the IOM was experimentally sectioned while maintaining the integrity of the distal radioulnar ligaments. Methods In 12 fresh-frozen cadaver forearms tested in a combined wrist-forearm simulator, the increase in gap between the radius and ulna, at the level of the DRUJ, was determined during cyclic forearm rotation following IOM sectioning...
May 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28423626/prognostic-value-of-loss-of-heterozygosity-and-sub-cellular-localization-of-smad4-varies-with-tumor-stage-in-colorectal-cancer
#2
Xu Jia, Chandrakumar Shanmugam, Ravi K Paluri, Nirag C Jhala, Michael P Behring, Venkat R Katkoori, Shajan P Sugandha, Sejong Bae, Temesgen Samuel, Upender Manne
BACKGROUND: Although loss of heterozygosity (LOH) at chromosome location 18q21 and decreased expression of SMAD4 in invasive colorectal cancers (CRCs) correlate with poor patient survival, the prognostic value of LOH at 18q21 and sub-cellular localization of SMAD4 have not been evaluated in relation to tumor stage. METHODS: Genomic DNA samples from 209 formalin-fixed, paraffin-embedded sporadic CRC tissues and their matching controls were analyzed for 18q21 LOH, and corresponding tissue sections were evaluated by immunohistochemistry for expression of SMAD4 and assessed for its sub-cellular localization (nuclear vs...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420560/does-revision-of-resection-margins-based-on-frozen-section-improve-overall-survival-following-pancreatoduodenectomy-for-pancreatic-ductal-adenocarcinoma-a-meta-analysis
#3
REVIEW
Savio G Barreto, Sanjay Pandanaboyana, Natasha Ironside, John A Windsor
BACKGROUND: Margin status is the main surgical determinant of long-term outcome in pancreatic cancer. Intraoperative frozen section (IOFS) detects microscopic positive margins at a stage when margin revision is possible. The aim of this study was to determine if IOFS driven-revision of pancreatic resection margin(s) improves overall survival (OS) in pancreatic cancer. METHODS: A systematic review of major reference databases was undertaken. Patients were divided into 3 groups based on initial FS (FSR0 for negative margin and FSR1 for positive microscopic margin) and final Permanent Section report (PSR0 for negative margin and PSR1 for positive microscopic margin): Group 1 (FSR0 → PSR0), Group 2 (FSR1 → PSR0), and Group 3 (FSR1 → PSR1)...
April 15, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28413924/erythropoietin-attenuates-axonal-injury-after-middle-cerebral-artery-occlusion-in-mice
#4
Rongliang Wang, Haiping Zhao, Jincheng Li, Yunxia Duan, Zhibin Fan, Zhen Tao, Fei Ju, Feng Yan, Yumin Luo
OBJECTIVE: Erythropoietin (EPO) confers potent neuroprotection against ischemic injury through a variety of mechanisms. However, the protective effect of EPO on axons after cerebral ischemia in adult mice is rarely covered. The purpose of this study was to investigate the potential neuroprotective effects of EPO on axons in mice after cerebral ischemia. METHODS: A total of 30 adult male C57 BL/6 mice were treated with EPO (5000 IU/kg) or vehicle after transient middle cerebral artery occlusion (MCAO)...
April 16, 2017: Neurological Research
https://www.readbyqxmd.com/read/28403869/debulking-surgery-for-venous-hemangioma-arising-from-the-epicardium-report-of-a-case
#5
Daichi Shikata, Takahiro Nakagomi, Yujiro Yokoyama, Yukiko Yamada, Masato Nakajima, Toshio Oyama, Taichiro Goto
BACKGROUND: Cardiac hemangiomas are rare benign vascular tumors that can occur in any cardiac layer: endocardium, myocardium, or epicardium. Histologically, cardiac hemangiomas may be classified as capillary, cavernous, or arteriovenous; venous hemangiomas are extremely rare. CASE PRESENTATION: A 46-year-old man reported experiencing precordial discomfort. Computed tomography revealed a massive tumor adjacent to the right ventricle. The right coronary artery was found to be located at the center of the tumor...
April 12, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28402060/evaluation-of-different-fragment-sizes-and-cryoprotectants-for-cryopreservation-of-feline-testicular-tissues
#6
B I Macente, G H Toniollo, M Apparicio, Cfm Mansano, H E Thomé, C L Canella, Meg Tozato, R R Gutierrez
This study aimed to evaluate tissue damage of feline testicles sectioned in two different sizes (0.3 or 0.5 cm(3) ) and submitted to different cryoprotectants (propanediol or glycerol). Testicles obtained from 12 domestic cats were sectioned in 0.3 and 0.5 cm(3) sized pieces and immediately evaluated by TBARS and semi-quantitatively by histomorphology. The remaining fragments were placed in cryotubes with 1 ml Egg yolk Tris Equex STM extender containing 3% glycerol or 3% propanediol and cryopreserved by fast-freezing technique...
April 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28400992/implementation-of-a-software-application-for-presurgical-case-history-review-of-frozen-section-pathology-cases
#7
Andrew P Norgan, Mathew L Okeson, Justin E Juskewitch, Kabeer K Shah, William R Sukov
BACKGROUND: The frozen section pathology practice at Mayo Clinic in Rochester performs ~20,000 intraoperative consultations a year (~70-80/weekday). To prepare for intraoperative consultations, surgical pathology fellows and residents review the case history, previous pathology, and relevant imaging the day before surgery. Before the work described herein, review of pending surgical pathology cases was a paper-based process requiring handwritten transcription from the electronic health record, a laborious and potentially error prone process...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28397683/-mohs-surgery-for-basal-cell-carcinoma
#8
Martin Glud, Silje Haukali Omland, John Paoli, Robert Gniadecki
Micrographic surgery is currently the only technique which ensures complete removal of basal cell carcinomas. The major limitation is the high set-up cost, which is particularly connected with specialized training of surgeons, technicians and the set-up of a histology facility for frozen tissue sectioning and staining. In the long run, however, the cost of Mohs surgery per patient does not exceed that of conventional surgery. The technique is very safe and has multiple advantages over any other treatment modality...
February 6, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28395052/assessment-of-the-intraoperative-consultation-service-rendered-by-general-pathologists-in-a-scenario-where-a-well-defined-decision-algorithm-is-followed
#9
Mahmoud A Khalifa, Sherine Salama, Rachel I Vogel, Molly E Klein, James Richter, Tanya Pulver, Sally A Mullany, Boris Winterhoff
Objectives: Intraoperative consultation (IOC) remains an area of general practice even within subspecialized pathology departments. This study assesses the IOCs rendered in a general pathology setting where surgeons integrate these results in a well-defined algorithm, developed with the input of specialized pathologists. Methods: The surgical decisions to perform lymphadenectomy in patients with endometrial adenocarcinoma operated on at our institution between January 2003 and June 2015 as a result of the IOC assessment of tumor size, histologic grade, and depth of invasion in the hysterectomy specimen were analyzed...
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28392125/vaginal-vs-robotic-hysterectomy-for-patients-with-endometrial-cancer-a-comparison-of-outcomes-and-cost-of-care
#10
C C Nitschmann, F Multinu, J N Bakkum-Gamez, C L Langstraat, J A Occhino, A L Weaver, W A Cliby, A Mariani, S C Dowdy
OBJECTIVE: To compare outcomes and cost for patients with endometrial cancer undergoing vaginal hysterectomy (VH) or robotic hysterectomy (RH), with or without lymphadenectomy (LND). METHODS: Patients undergoing planned VH (and laparoscopic LND) or RH (and robotic LND) between January 2007 and November 2012 were reviewed. Patients with stage IV disease, synchronous cancer, synchronous surgery, or treated with palliative intent were excluded. Patients were objectively triaged to LND per institutional protocol based on frozen section...
April 6, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28389797/laparoscopic-subtotal-gastrectomy-for-advanced-gastric-cancer-technical-aspects-and-surgical-nutritional-and-oncological-outcomes
#11
Masaya Nakauchi, Koichi Suda, Kenichi Nakamura, Susumu Shibasaki, Kenji Kikuchi, Tetsuya Nakamura, Shinichi Kadoya, Yoshinori Ishida, Kazuki Inaba, Keizo Taniguchi, Ichiro Uyama
BACKGROUND: Higher morbidity in total gastrectomy than in distal gastrectomy has been reported, but laparoscopic subtotal gastrectomy (LsTG) has been reported to be safe and feasible in early gastric cancer (GC). We determined the surgical, nutritional and oncological outcomes of LsTG for advanced gastric cancer (AGC). METHODS: Of the 816 consecutive patients with GC who underwent radical gastrectomy at our institution between 2008 and 2012, 253 who underwent curative laparoscopic gastrectomy (LG) for AGC were enrolled...
April 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28389594/giant-fibroepithelial-polyp-of-the-ureter
#12
Mayank Gupta, Sanjeet Roy, Cornerstone Wann, Anu Eapen
Giant fibroepithelial polyp is a rare cause of ureteric/ureteropelvic junction (UPJ) obstruction. We report a rare case of giant fibroepithelial polyp in a 32-year-old woman involving the whole length of the ureter, reaching up to the UPJ which was clinically and radiologically considered to be urothelial carcinoma. Frozen section showed a polypoid lesion lined by urothelium with no evidence of dysplasia or malignancy. Subsequently, nephroureterectomy was done as there was marked renal hydronephrosis and it was impossible to separate the polyp from the wall of the ureter...
April 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28387647/management-of-childhood-thyroid-nodules-surgical-and-endocrinological-experience-in-more-than-one-hundred-cases
#13
Emre Divarcı, Ülgen Celtik, Zafer Dökümcü, Orkan Ergün, Geylani Özok, Samim Özen, Damla Gökşen Şimşek, Şükran Darcan, Nazan Çetingül, Aylin Oral, Yeşim Ertan, Bengü Demirağ, Ahmet Çelik
OBJECTIVE: The management of childhood thyroid nodules is still a big challenge for clinicians. In this study, we aimed to present our surgical and endocrinological experience in more than one hundred cases as a large experience in children. METHODS: Retrospective analysis of patients admitted with a thyroid nodule between 2006-2014 was performed. Detailed ultrasonography and fine needle aspiration biopsy(FNAB) were the corner stones of the diagnostic approach. RESULTS: One hundred-three children(72F,31M) with a mean age of 13...
April 7, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28384401/computational-approach-to-measuring-myocyte-disarray-in-animal-models-of-heart-disease
#14
William Wan, Leslie Leinwand
In cardiovascular disease research, studies often include measuring cardiac function and performing histological examination of heart tissue. After measuring contractility, hearts from animals such as mice and rats are often frozen or fixed, sliced, and stained to quantify the morphology of various structures such as extracellular matrix proteins, cell nuclei, and F-actin. Traditional scoring methods have largely consisted of assessing sections of images for the presence or absence of myocyte disarray. These approaches require unbiased manual assessment, which can require extra personnel, and are not scalable to the quantity of data that can be generated by modern automated experimental techniques...
April 6, 2017: Current Protocols in Human Genetics
https://www.readbyqxmd.com/read/28381253/localization-of-staphylococcus-aureus-in-tissue-from-the-nasal-vestibule-in-healthy-carriers
#15
Anne-Merethe Hanssen, Bert Kindlund, Niels Christian Stenklev, Anne-Sofie Furberg, Silje Fismen, Renate Slind Olsen, Mona Johannessen, Johanna Ulrica Ericson Sollid
BACKGROUND: Colonization of the body is an important step in Staphylococcus aureus infection. S. aureus colonizes skin and mucous membranes in humans and several animal species. One important ecological niche of S. aureus is the anterior nares. More than 60% of the S. aureus in the nose are found in vestibulum nasi. Our aim was to describe the localization of S. aureus in nasal tissue from healthy carriers. METHODS: Punch skin biopsies were taken from vestibulum nasi from healthy volunteers (S...
April 5, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28379121/the-effect-of-poverty-influenced-food-related-consumer-behaviors-on-obesity-an-analysis-of-the-nhanes-flexible-consumer-behavioral-module
#16
Kellie O'Dare Wilson
Despite extensive research investigating obesity, the problem continues to increase, particularly in poor, minority, and under-resourced communities. However, the literature continues to demonstrate many obesity-predicating variables are outside of personal volitional control, such as food-related consumer behaviors, which are strongly influenced by income and environment. This cross-sectional study (n = 5,109) employed secondary data analysis to quantitatively examine the effect of food-related consumer variables on obesity while controlling for covariates...
May 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28375928/sentinel-node-and-ovarian-tumors-a-series-of-20-patients
#17
Reita H Nyberg, Pasi Korkola, Johanna U Mäenpää
OBJECTIVE: Intraoperative detection of ovarian sentinel nodes has been shown to be feasible. We examined the detection rate and locations of sentinel nodes in patients with ovarian tumors. We also aimed to assess the reliability of sentinel node method in predicting regional lymph node metastasis. METHODS: Twenty patients scheduled for laparotomy because of a pelvic mass were recruited to the study. In the beginning of the laparotomy, radioisotope and blue dye were injected under the serosa next to the junction of the ovarian tumor and suspensory ligament...
April 3, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28374768/cortical-laminar-tau-deposits-and-activated-astrocytes-in-alzheimer-s-disease-visualised-by-3-h-thk5117-and-3-h-deprenyl-autoradiography
#18
Laetitia Lemoine, Laure Saint-Aubert, Inger Nennesmo, Per-Göran Gillberg, Agneta Nordberg
Hyperphosphorylated tau protein deposits and, inflammatory processes are characteristic components of Alzheimer disease (AD) pathology. We here aimed to visualize in vitro the distribution of tau deposits and activated astrocytes across the cortical layers in autopsy AD brain tissue using the radiotracers (3)H-THK5117 and (3)H-deprenyl. (3)H-THK5117 and (3)H-deprenyl autoradiographies were carried out on frozen brain sections from three AD patients and one healthy control. (3)H-THK5117 showed a distinct laminar cortical binding similar to (3)H-deprenyl autoradiography, with an extensive binding in the superficial and deep layers of the temporal neocortices, whereas the middle frontal gyrus showed an even binding throughout the layers...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28373982/the-distribution-of-phosphatidylcholine-species-in-superficial-type-pharyngeal-carcinoma
#19
Seiji Ishikawa, Ichiro Tateya, Takahiro Hayasaka, Satoru Shinriki, Noritaka Masaki, Shigeru Hirano, Morimasa Kitamura, Manabu Muto, Shuko Morita, Mitsutoshi Setou, Juichi Ito
Objectives. Superficial-type pharyngeal squamous cell carcinoma (STPSCC) is defined as carcinoma in situ or microinvasive squamous cell carcinoma without invasion to the muscular layer. An exploration of the biological characteristics of STPSCC could uncover the invasion mechanism of this carcinoma. Phosphatidylcholine (PC) in combination with fatty acids is considered to play an important role in cell motility. Imaging mass spectrometry (IMS) is especially suitable for phospholipid analysis because this technique can distinguish even fatty acid compositions...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28373428/effect-of-whole-abdominal-irradiation-on-penetration-depth-of-doxorubicin-in-normal-tissue-after-pressurized-intraperitoneal-aerosol-chemotherapy-pipac-in-a-post-mortem-swine-model
#20
Veria Khosrawipour, Tanja Khosrawipour, Yousef Hedayat-Pour, David Diaz-Carballo, Alexander Bellendorf, Hugo Böse-Ribeiro, Ralph Mücke, Nirushika Mohanaraja, Irenäus Anton Adamietz, Khashayar Fakhrian
BACKGROUND: This study was performed to evaluate the impact of whole-abdominal irradiation on local penetration of doxorubicin into the peritoneum and the abdominal organs in a post-mortem swine model. MATERIALS AND METHODS: Doxorubicin was aerosolized into the abdominal cavity of swine at a pressure of 12 mmHg CO2 at room temperature (25°). One swine was subjected to pressurized intraperitoneal aerosol chemotherapy (PIPAC) using Micropump(©) without irradiation; the second one received 2 Gy and the third one 7 Gy whole-abdominal irradiation, 15 min prior to PIPAC application...
April 2017: Anticancer Research
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