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https://www.readbyqxmd.com/read/28211822/robot-assisted-end-effector-based-gait-training-in-chronic-stroke-patients-a%C3%A2-multicentric-uncontrolled-observational-retrospective-clinical-study
#1
Stefano Mazzoleni, Antonella Focacci, Marco Franceschini, Andreas Waldner, Chiara Spagnuolo, Elena Battini, Donatella Bonaiuti
BACKGROUND: Until now studies report inconclusive results as regards the effectiveness of exclusive use of robot-assisted training and clinical indications in stroke patients. OBJECTIVE: To evaluate if the only robot-assisted end-effector-based gait training can be feasible in chronic stroke subjects in terms of gait recovery. METHODS: Five rehabilitation centers participated and one hundred chronic post-stroke patients were recruited. Patients underwent a robot-assisted end-effector-based gait training as only rehabilitation treatment...
February 15, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28210028/a-preliminary-study-of-the-measurement-of-overload-applied-to-the-foot-support-of-a-wheelchair-and-a-seated-postural-support-device
#2
Satoshi Shirogane, Takashi Handa, Yoshihiko Kozai, Yusuke Maeda
[Purpose] The mechanical strength of wheelchair and seating products is specified by standards to ensure user safety. However, some individual users are affected by severe spasticity resulting from cerebral palsy that occasionally breaks such devices. Until recently, reports of quantitative measurement of these mechanical overloads have been scarce, and the exact loads applied have been unknown. This study aimed to conduct a sampling survey prior to conducting a future full-scale study. [Subjects and Methods] Using two force plates, we measured the load on the foot support applied by three participants with cerebral palsy...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28206686/nte-pnpla6-is-expressed-in-mature-schwann-cells-and-is-required-for-glial-ensheathment-of-remak-fibers
#3
Janis McFerrin, Bruce L Patton, Elizabeth R Sunderhaus, Doris Kretzschmar
Neuropathy target esterase (NTE) or patatin-like phospholipase domain containing 6 (PNPLA6) was first linked with a neuropathy occurring after organophosphate poisoning and was later also found to cause complex syndromes when mutated, which can include mental retardation, spastic paraplegia, ataxia, and blindness. NTE/PNPLA6 is widely expressed in neurons but experiments with its Drosophila orthologue Swiss-cheese (SWS) suggested that it may also have glial functions. Investigating whether NTE/PNPLA6 is expressed in glia, we found that NTE/PNPLA6 is expressed by Schwann cells in the sciatic nerve of adult mice with the most prominent expression in nonmyelinating Schwann cells...
February 16, 2017: Glia
https://www.readbyqxmd.com/read/28206670/altered-expression-of-cxcr3-and-ccr6-and-their-ligands-in-htlv-1-carriers-and-ham-tsp-patients
#4
Houshang Rafatpanah, Mehdi Felegari, Mahmoud Reza Azarpazhooh, Rosita Vakili, Taraneh Rajaei, Ian Hampson, Golmahossein Hassanshahi, Narges Valizadeh, Sina Gerayli, Hamid Farjifard, Shadi Zamanian, Farzad MollaHosseini, Seyed Abdolrahim Rezaee
Recruitment of leukocytes by chemokines and chemokine receptors to CNS plays a crucial role in the induction of inflammatory response in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In the present study, chemokine and chemokine receptors involved in trafficking of lymphocytes to the CNS were measured in HAM/TSP patients, HTLV-1 asymptomatic carriers (ACs), and healthy controls. The PVL, CCR6 and CXCR3 mRNA expression, and CXCL9 and CXCL10 protein levels were measured in all subjects...
February 16, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28202830/-usefulness-of-bolus-administration-using-the-flex-mode-bolus-infusion-mode-for-baclofen-tolerance
#5
Kazunori Tanaka
Intrathecal baclofen(ITB)is used to treat intractable spasticity of various etiologies and can provide better control of spasticity through the adjustment of the dose administered through the pump. However, in patients who develop tolerance to baclofen with the standard simple continuous mode, a sharp increase in dose becomes necessary, and spasticity can become harder to control. We investigated whether switching from the simple continuous mode to the bolus infusion mode was effective in controlling spasticity in patients with baclofen tolerance...
February 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28202003/prevalence-and-risk-factors-for-human-t-lymphotropic-virus-type-1-htlv-1-among-maintenance-hemodialysis-patients
#6
Rilma F S Santos, Gildásio C Conceição, Márcia S Martins, Angiolina Kraychete, Maria A C Penalva, Edgar M Carvalho, Antonio Alberto Lopes, Paulo Novis Rocha
BACKGROUND: Infection with the human T-cell lymphotropic virus type 1 (HTLV-1), although asymptomatic in most cases, can lead to potentially grave consequences, such as adult T-cell leukemia-lymphoma and HTLV-1-associated myelopathy / tropical spastic paraparesis. Its prevalence varies widely across different populations and geographic regions. A population-based study in the city of Salvador, located in the Northeast region of Brazil, showed an overall prevalence of HTLV-1 seropositivity of 1...
February 15, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28195350/overcoming-the-divide-between-ataxias-and-spastic-paraplegias-shared-phenotypes-genes-and-pathways
#7
REVIEW
Matthis Synofzik, Rebecca Schüle
Autosomal-dominant spinocerebellar ataxias, autosomal-recessive spinocerebellar ataxias, and hereditary spastic paraplegias have traditionally been designated in separate clinicogenetic disease classifications. This classification system still largely frames clinical thinking and genetic workup in clinical practice. Yet, with the advent of next-generation sequencing, phenotypically unbiased studies have revealed the limitations of this classification system. Various genes (eg, SPG7, SYNE1, PNPLA6) traditionally rooted in either the ataxia or hereditary spastic paraplegia classification system have now been shown to cause ataxia on the one end of the disease continuum and hereditary spastic paraplegia on the other...
February 14, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28193763/neurologic-involvement-in-patients-with-atypical-chediak-higashi-disease
#8
Wendy J Introne, Wendy Westbroek, Catherine A Groden, Vikas Bhambhani, Gretchen A Golas, Eva H Baker, Tanya J Lehky, Joseph Snow, Shira G Ziegler, May Christine V Malicdan, David R Adams, Heidi M Dorward, Richard A Hess, Marjan Huizing, William A Gahl, Camilo Toro
OBJECTIVE: To delineate the developmental and progressive neurodegenerative features in 9 young adults with the atypical form of Chediak-Higashi disease (CHD) enrolled in a natural history study. METHODS: Patients with atypical clinical features, but diagnostically confirmed CHD by standard evaluation of blood smears and molecular genotyping, underwent complete neurologic evaluation, MRI of the brain, electrophysiologic examination, and neuropsychological testing...
14, 2017: Neurology
https://www.readbyqxmd.com/read/28193273/stub1-chip-mutations-cause-gordon-holmes-syndrome-as-part-of-a-widespread-multisystemic-neurodegeneration-evidence-from-four-novel-mutations
#9
Stefanie Nicole Hayer, Tine Deconinck, Benjamin Bender, Katrien Smets, Stephan Züchner, Selina Reich, Ludger Schöls, Rebecca Schüle, Peter De Jonghe, Jonathan Baets, Matthis Synofzik
BACKGROUND: CHIP, the protein encoded by STUB1, is a central component of cellular protein homeostasis and interacts with several key proteins involved in the pathogenesis of manifold neurodegenerative diseases. This gives rise to the hypothesis that mutations in STUB1 might cause a far more multisystemic neurodegenerative phenotype than the previously reported cerebellar ataxia syndrome. METHODS: Whole exome sequencing data-sets from n = 87 index subjects of two ataxia cohorts were screened for individuals with STUB1 mutations...
February 13, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28193113/book-review-spasticity-diagnosis-and-management-brashear-a-spasticity-diagnosis-and-management-2nd-edition-new-york-ny-demos-medical-2016-512-pp-135-isbn-9781620700723
#10
https://www.readbyqxmd.com/read/28191352/hybrid-assistive-neuromuscular-dynamic-stimulation-therapy-a-new-strategy-for-improving-upper-extremity-function-in-patients-with-hemiparesis-following-stroke
#11
REVIEW
Toshiyuki Fujiwara, Michiyuki Kawakami, Kaoru Honaga, Michi Tochikura, Kaoru Abe
Hybrid Assistive Neuromuscular Dynamic Stimulation (HANDS) therapy is one of the neurorehabilitation therapeutic approaches that facilitates the use of the paretic upper extremity (UE) in daily life by combining closed-loop electromyography- (EMG-) controlled neuromuscular electrical stimulation (NMES) with a wrist-hand splint. This closed-loop EMG-controlled NMES can change its stimulation intensity in direct proportion to the changes in voluntary generated EMG amplitudes recorded with surface electrodes placed on the target muscle...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28188024/robotic-assisted-gait-training-improves-walking-abilities-in-diplegic-children-with-cerebral-palsy
#12
L Wallard, G Dietrich, Y Kerlirzin, J Bredin
The robotic-assisted gait training therapy (RAGT), based on intensity and repetition of movement, presents beneficial effects on recovery and improvement of postural and locomotor functions of the patient. This study sought to highlight the effect of this RAGT on the dynamic equilibrium control during walking in children with Cerebral Palsy (CP) by analyzing the different postural strategies of the fullbody (upper/lower body) before and after this RAGT in order to generate forward motion while maintaining balance...
February 2, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28187749/identification-of-a-large-intronic-transposal-insertion-in-slc17a5-causing-sialic-acid-storage-disease
#13
Maja Tarailo-Graovac, Britt I Drögemöller, Wyeth W Wasserman, Colin J D Ross, Ans M W van den Ouweland, Niklas Darin, Gittan Kollberg, Clara D M van Karnebeek, Maria Blomqvist
BACKGROUND: Sialic acid storage diseases are neurodegenerative disorders characterized by accumulation of sialic acid in the lysosome. These disorders are caused by mutations in SLC17A5, the gene encoding sialin, a sialic acid transporter located in the lysosomal membrane. The most common form of sialic acid storage disease is the slowly progressive Salla disease, presenting with hypotonia, ataxia, epilepsy, nystagmus and findings of cerebral and cerebellar atrophy. Hypomyelination and corpus callosum hypoplasia are typical as well...
February 10, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28185943/hepatitis-c-virus-hcv-and-human-t-cell-lymphotropic-virus-type-1-htlv-1-coinfection-impact-on-liver-disease-virological-markers-and-neurological-outcome
#14
Otávio M Espíndola, Alexandre G Vizzoni, Elisabeth Lampe, Maria José Andrada-Serpa, Abelardo Q C Araújo, Ana Claudia C Leite
OBJECTIVES: HTLV-1 infection is associated with neurological abnormalities, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and peripheral neuropathy (PN). HCV infection is the leading cause of chronic liver disease worldwide, and causes PN in approximately 9% of patients. Because the interplay between these potentially neuropathogenic viruses in a same individual is still poorly understood we evaluated clinical and laboratory outcomes in coinfected patients and compared them with controls...
February 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28185483/genital-nerve-stimulation-is-tolerable-and-effective-for-bladder-inhibition-in-sensate-individuals-with-incomplete-sci
#15
Steven W Brose, Dennis J Bourbeau, Kenneth J Gustafson
BACKGROUND: Neurogenic detrusor overactivity after spinal cord injury (SCI) causes urinary incontinence and reduces bladder capacity. Surface electrical genital nerve stimulation (GNS) acutely inhibits reflex bladder contractions. The stimulation amplitude selected for GNS is typically twice the amplitude that is required to evoke the pudendal-anal reflex. There is concern about the ability of persons with sensation to comfortably tolerate effective levels of GNS. The objective of this work is to determine if persons with incomplete SCI are able to tolerate acute GNS for bladder inhibition...
February 10, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28182676/the-swimming-test-is-effective-for-evaluating-spasticity-after-contusive-spinal-cord-injury
#16
Youngjae Ryu, Toru Ogata, Motoshi Nagao, Taku Kitamura, Kazuhito Morioka, Yoshinori Ichihara, Toru Doi, Yasuhiro Sawada, Masami Akai, Ryohei Nishimura, Naoki Fujita
Spasticity is a frequent chronic complication in individuals with spinal cord injury (SCI). However, the severity of spasticity varies in patients with SCI. Therefore, an evaluation method is needed to determine the severity of spasticity. We used a contusive SCI model that is suitable for clinical translation. In this study, we examined the feasibility of the swimming test and an EMG for evaluating spasticity in a contusive SCI rat model. Sprague-Dawley rats received an injury at the 8th thoracic vertebra...
2017: PloS One
https://www.readbyqxmd.com/read/28182361/evaluation-of-line-immunoassay-to-detect-htlv-1-infection-in-an-endemic-area-southwestern-japan-comparison-with-polymerase-chain-reaction-and-western-blot
#17
Kazumi Umeki, Kunihiko Umekita, Yuuki Hashikura, Ikuo Yamamoto, Kazuyoshi Kubo, Yasuhiro Nagatomo, Akihiko Okayama
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) has been recognized as a cause of adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis, and HTLV-1-associated uveitis. HTLV-1 infection is normally detected by screening for HTLV-1 antibodies, and positive samples are confirmed by Western blot (WB). However, WB fails to confirm some samples that were positive for HTLV-1 antibodies on screening. Line immunoassay (LIA) is commonly used in Europe and Brazil, but not in Japan...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28179632/clinical-exome-sequencing-for-cerebellar-ataxia-and-spastic-paraplegia-uncovers-novel-gene-disease-associations-and-unanticipated-rare-disorders
#18
Bart P van de Warrenburg, Meyke I Schouten, Susanne T de Bot, Sascha Vermeer, Rowdy Meijer, Maartje Pennings, Christian Gilissen, Michèl Aap Willemsen, Hans Scheffer, Erik-Jan Kamsteeg
No abstract text is available yet for this article.
February 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28178142/treatment-of-rheumatoid-arthritis-with-biologics-may-exacerbate-htlv-1-associated-conditions-a-case-report
#19
Yukiko Terada, Koju Kamoi, Kyoko Ohno-Matsui, Kazunori Miyata, Chinami Yamano, Ariella Coler-Reilly, Yoshihisa Yamano
RATIONALE: There are roughly 5 to 10 million persons infected with human T-lymphotropic virus type 1 (HTLV-1) worldwide, and the safety of treating this population with biologics remains poorly understood. PATIENT CONCERNS AND DIAGNOSIS: An HTLV-1-infected 66-year-old female with HTLV-1 uveitis (HU) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Her HU had been in remission and her HAM/TSP symptoms had been managed effectively with oral steroids for years...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28174481/what-do-the-relationships-between-functional-classification-systems-of-children-with-cerebral-palsy-tell-us
#20
Akmer Mutlu, Pelin Pistav-Akmese, Bilge Nur Yardımcı, Tuncay Ogretmen
[Purpose] To examine the distribution of and relationship between the Gross Motor Function, Manual Ability, and Communication Function Classification Systems in different limbs of children with spastic cerebral palsy. We also investigated whether the four predicting variables of gender, age, manual ability, and gross motor classifications could significantly predict effective and non-effective communicator groups in communication function. [Subjects and Methods] This retrospective cross-sectional study included 327 children with a mean age of 10...
December 2016: Journal of Physical Therapy Science
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