Francesco Suriano, Sara Vieira-Silva, Gwen Falony, Alice de Wouters d'Oplinter, Paola Paone, Nathalie M Delzenne, Amandine Everard, Jeroen Raes, Matthias Van Hul, Patrice D Cani
Diet-induced obesity contributes to the development of type 2 diabetes, insulin resistance, metabolic inflammation, oxidative and endoplasmic reticulum (ER) stress. Overall, obesity is associated with deviations in the composition and functionality of the gut microbiota. There are many divergent findings regarding the link between the excessive intake of certain dietary components (i.e., fat and sugar) and obesity development. We therefore investigated the effect of specific diets, with a different content in sugar and fat, in promoting obesity and related comorbidities as well as their impact on microbial load and gut microbiota composition/diversity...
December 14, 2022: American Journal of Physiology. Endocrinology and Metabolism