Read by QxMD icon Read

Patrice cani

Julia König, Jerry Wells, Patrice D Cani, Clara L García-Ródenas, Tom MacDonald, Annick Mercenier, Jacqueline Whyte, Freddy Troost, Robert-Jan Brummer
The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a tight barrier against the ingress of harmful substances, and protect against a reaction to omnipresent harmless compounds. A dysfunctional intestinal barrier is associated with various diseases and disorders. In this review, the role of intestinal permeability in common disorders such as infections with intestinal pathogens, inflammatory bowel disease, irritable bowel syndrome, obesity, celiac disease, non-celiac gluten sensitivity, and food allergies will be discussed...
October 20, 2016: Clinical and Translational Gastroenterology
Patrice D Cani, Claude Knauf
BACKGROUND: Changes in gut microbiota composition and activity have been associated with different metabolic disorders, including obesity, diabetes, and cardiometabolic disorders. Recent evidence suggests that different organs are directly under the influence of bacterial metabolites that may directly or indirectly regulate physiological and pathological processes. SCOPE OF REVIEW: We reviewed seminal as well as recent papers showing that gut microbes influence energy, glucose and lipid homeostasis by controlling different metabolic routes such as endocrine, enteric and central nervous system...
September 2016: Molecular Metabolism
Patrice D Cani
No abstract text is available yet for this article.
October 2016: Nature Reviews. Gastroenterology & Hepatology
Owein Guillemot-Legris, Julien Masquelier, Amandine Everard, Patrice D Cani, Mireille Alhouayek, Giulio G Muccioli
BACKGROUND: Obesity and its associated disorders are becoming a major health issue in many countries. The resulting low-grade inflammation not only affects the periphery but also the central nervous system. We set out to study, in a time-dependent manner, the effects of a high-fat diet on different regions of the central nervous system with regard to the inflammatory tone. METHODS: We used a diet-induced obesity model and compared at several time-points (1, 2, 4, 6, 8, and 16 weeks) a group of mice fed a high-fat diet with its respective control group fed a standard diet...
2016: Journal of Neuroinflammation
Anne Drougard, Audren Fournel, Alysson Marlin, Etienne Meunier, Anne Abot, Tereza Bautzova, Thibaut Duparc, Katie Louche, Aurelie Batut, Alexandre Lucas, Sophie Le-Gonidec, Jean Lesage, Xavier Fioramonti, Cedric Moro, Philippe Valet, Patrice D Cani, Claude Knauf
Apelin is a bioactive peptide involved in the control of energy metabolism. In the hypothalamus, chronic exposure to high levels of apelin is associated with an increase in hepatic glucose production, and then contributes to the onset of type 2 diabetes. However, the molecular mechanisms behind deleterious effects of chronic apelin in the brain and consequences on energy expenditure and thermogenesis are currently unknown. We aimed to evaluate the effects of chronic intracerebroventricular (icv) infusion of apelin in normal mice on hypothalamic inflammatory gene expression, energy expenditure, thermogenesis and brown adipose tissue functions...
2016: Scientific Reports
Audrey M Neyrinck, Barbara Pachikian, Bernard Taminiau, Georges Daube, Raphaël Frédérick, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne
Inulin-type fructans (ITF) are known for their capacity to modulate gut microbiota, energy metabolism and to improve glycemia in several animal models of obesity, and in humans. The potential contribution of ITF as modulators of sugar digestion by host enzymes has not been evaluated yet. A sucrose challenge has been performed on naive mice fed a standard diet supplemented with or without native chicory inulin (Fibruline 5%) for 3 weeks. The area under the curve of glycemia as well as sucrase activity in the small intestine were lowered after inulin treatment...
2016: PloS One
Thibaut Duparc, Hubert Plovier, Vannina G Marrachelli, Matthias Van Hul, Ahmed Essaghir, Marcus Ståhlman, Sébastien Matamoros, Lucie Geurts, Mercedes M Pardo-Tendero, Céline Druart, Nathalie M Delzenne, Jean-Baptiste Demoulin, Schalk W van der Merwe, Jos van Pelt, Fredrik Bäckhed, Daniel Monleon, Amandine Everard, Patrice D Cani
OBJECTIVE: To examine the role of hepatocyte myeloid differentiation primary-response gene 88 (MyD88) on glucose and lipid metabolism. DESIGN: To study the impact of the innate immune system at the level of the hepatocyte and metabolism, we generated mice harbouring hepatocyte-specific deletion of MyD88. We investigated the impact of the deletion on metabolism by feeding mice with a normal control diet or a high-fat diet for 8 weeks. We evaluated body weight, fat mass gain (using time-domain nuclear magnetic resonance), glucose metabolism and energy homeostasis (using metabolic chambers)...
May 5, 2016: Gut
Emilie Catry, Audrey M Neyrinck, Irina Lobysheva, Barbara D Pachikian, Matthias Van Hul, Patrice D Cani, Chantal Dessy, Nathalie M Delzenne
SCOPE: Western diets are characterized by low intake of n-3 PUFA compensated by constant amounts of n-6 PUFA. Reduced intake of n-3 PUFA is associated with increased cardiovascular risk, as observed in NAFLD patients. The study aimed evaluating the impact of dietary n-3 PUFA depletion on endothelial function, an early key event of cardiovascular diseases. METHODS & RESULTS: C57Bl/6J or apoE(-/-) mice were fed control or n-3 PUFA depleted-diets for 12 weeks. Mice fed n-3 PUFA depleted-diet developed a hepatic steatosis, linked to changes in hepatic expression of genes controlled by Sterol Regulatory Element Binding Protein-1 and -2...
May 2, 2016: Molecular Nutrition & Food Research
Audrey M Neyrinck, Usune Etxeberria, Bernard Taminiau, Georges Daube, Matthias Van Hul, Amandine Everard, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne
SCOPE: Binge consumption of alcohol is an alarming global health problem. Acute ethanol intoxication is characterized by inflammation and oxidative stress, which could be promoted by gut barrier function alterations. In this study, we have tested the hypothesis of the hepatoprotective effect of rhubarb extract in a mouse model of binge drinking and we explored the contribution of the gut microbiota in the related- metabolic effects. METHODS AND RESULTS: Mice were fed a control diet supplemented with or without 0...
March 18, 2016: Molecular Nutrition & Food Research
Audren Fournel, Alysson Marlin, Anne Abot, Charles Pasquio, Carla Cirillo, Patrice D Cani, Claude Knauf
The gastrointestinal tract is an important interface of exchange between ingested food and the body. Glucose is one of the major dietary sources of energy. All along the gastrointestinal tube, e.g., the oral cavity, small intestine, pancreas, and portal vein, specialized cells referred to as glucosensors detect variations in glucose levels. In response to this glucose detection, these cells send hormonal and neuronal messages to tissues involved in glucose metabolism to regulate glycemia. The gastrointestinal tract continuously communicates with the brain, especially with the hypothalamus, via the gut-brain axis...
May 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
Owein Guillemot-Legris, Valentin Mutemberezi, Patrice D Cani, Giulio G Muccioli
Oxysterols are bioactive lipids derived from cholesterol that are linked to inflammatory processes. Because obesity and metabolic syndrome are characterized by inflammation and altered cholesterol metabolism, we sought to investigate the variations of oxysterol levels and their metabolic pathways induced by obesity in the liver, hypothalamus, adipose tissue and plasma. To this end, we used diet-induced and genetic (ob/ob and db/db) models of obesity. Among the oxysterols measured, we found that 4β-oxysterol levels were consistently decreased in the high-fat diet study, at different time-points, and in the ob/ob model...
2016: Scientific Reports
Patrice D Cani, Hubert Plovier, Matthias Van Hul, Lucie Geurts, Nathalie M Delzenne, Céline Druart, Amandine Everard
Various metabolic disorders are associated with changes in inflammatory tone. Among the latest advances in the metabolism field, the discovery that gut microorganisms have a major role in host metabolism has revealed the possibility of a plethora of associations between gut bacteria and numerous diseases. However, to date, few mechanisms have been clearly established. Accumulating evidence indicates that the endocannabinoid system and related bioactive lipids strongly contribute to several physiological processes and are a characteristic of obesity, type 2 diabetes mellitus and inflammation...
March 2016: Nature Reviews. Endocrinology
Laure B Bindels, Audrey M Neyrinck, Sandrine P Claus, Caroline I Le Roy, Corinne Grangette, Bruno Pot, Inés Martinez, Jens Walter, Patrice D Cani, Nathalie M Delzenne
Cancer cachexia is a multifactorial syndrome that includes muscle wasting and inflammation. As gut microbes influence host immunity and metabolism, we investigated the role of the gut microbiota in the therapeutic management of cancer and associated cachexia. A community-wide analysis of the caecal microbiome in two mouse models of cancer cachexia (acute leukaemia or subcutaneous transplantation of colon cancer cells) identified common microbial signatures, including decreased Lactobacillus spp. and increased Enterobacteriaceae and Parabacteroides goldsteinii/ASF 519...
June 2016: ISME Journal
Audren Fournel, Anne Drougard, Thibaut Duparc, Alysson Marlin, Stuart M Brierley, Joel Castro, Sophie Le-Gonidec, Bernard Masri, André Colom, Alexandre Lucas, Perrine Rousset, Nicolas Cenac, Nathalie Vergnolle, Philippe Valet, Patrice D Cani, Claude Knauf
OBJECTIVE: The gut-brain axis is considered as a major regulatory checkpoint in the control of glucose homeostasis. The detection of nutrients and/or hormones in the duodenum informs the hypothalamus of the host's nutritional state. This process may occur via hypothalamic neurons modulating central release of nitric oxide (NO), which in turn controls glucose entry into tissues. The enteric nervous system (ENS) modulates intestinal contractions in response to various stimuli, but the importance of this interaction in the control of glucose homeostasis via the brain is unknown...
November 12, 2015: Gut
Marc Schneeberger, Amandine Everard, Alicia G Gómez-Valadés, Sébastien Matamoros, Sara Ramírez, Nathalie M Delzenne, Ramon Gomis, Marc Claret, Patrice D Cani
Recent evidence indicates that the gut microbiota plays a key role in the pathophysiology of obesity. Indeed, diet-induced obesity (DIO) has been associated to substantial changes in gut microbiota composition in rodent models. In the context of obesity, enhanced adiposity is accompanied by low-grade inflammation of this tissue but the exact link with gut microbial community remains unknown. In this report, we studied the consequences of high-fat diet (HFD) administration on metabolic parameters and gut microbiota composition over different periods of time...
2015: Scientific Reports
Patrice D Cani, Amandine Everard
Microbe communication with host mammalian cells and external factors such as diet influences this multifaceted ecosystem. A recent study shows that interactions between microbial genes and dietary elements are dynamic processes that may help to characterize an organism's niche and eventually its impact on the overall community and host metabolism.
November 3, 2015: Cell Metabolism
Robert W Hutkins, Janina A Krumbeck, Laure B Bindels, Patrice D Cani, George Fahey, Yong Jun Goh, Bruce Hamaker, Eric C Martens, David A Mills, Robert A Rastal, Elaine Vaughan, Mary Ellen Sanders
The prebiotic concept was introduced twenty years ago, and despite several revisions to the original definition, the scientific community has continued to debate what it means to be a prebiotic. How prebiotics are defined is important not only for the scientific community, but also for regulatory agencies, the food industry, consumers and healthcare professionals. Recent developments in community-wide sequencing and glycomics have revealed that more complex interactions occur between putative prebiotic substrates and the gut microbiota than previously considered...
February 2016: Current Opinion in Biotechnology
Robert Caesar, Valentina Tremaroli, Petia Kovatcheva-Datchary, Patrice D Cani, Fredrik Bäckhed
Dietary lipids may influence the abundance of circulating inflammatory microbial factors. Hence, inflammation in white adipose tissue (WAT) induced by dietary lipids may be partly dependent on their interaction with the gut microbiota. Here, we show that mice fed lard for 11 weeks have increased Toll-like receptor (TLR) activation and WAT inflammation and reduced insulin sensitivity compared with mice fed fish oil and that phenotypic differences between the dietary groups can be partly attributed to differences in microbiota composition...
October 6, 2015: Cell Metabolism
Marcin Kierczak, Jagoda Jabłońska, Simon K G Forsberg, Matteo Bianchi, Katarina Tengvall, Mats Pettersson, Veronika Scholz, Jennifer R S Meadows, Patric Jern, Örjan Carlborg, Kerstin Lindblad-Toh
UNLABELLED: High-throughput genotyping and sequencing technologies facilitate studies of complex genetic traits and provide new research opportunities. The increasing popularity of genome-wide association studies (GWAS) leads to the discovery of new associated loci and a better understanding of the genetic architecture underlying not only diseases, but also other monogenic and complex phenotypes. Several softwares are available for performing GWAS analyses, R environment being one of them...
December 1, 2015: Bioinformatics
Nathalie M Delzenne, Patrice D Cani, Amandine Everard, Audrey M Neyrinck, Laure B Bindels
Each human intestine harbours not only hundreds of trillions of bacteria but also bacteriophage particles, viruses, fungi and archaea, which constitute a complex and dynamic ecosystem referred to as the gut microbiota. An increasing number of data obtained during the last 10 years have indicated changes in gut bacterial composition or function in type 2 diabetic patients. Analysis of this 'dysbiosis' enables the detection of alterations in specific bacteria, clusters of bacteria or bacterial functions associated with the occurrence or evolution of type 2 diabetes; these bacteria are predominantly involved in the control of inflammation and energy homeostasis...
October 2015: Diabetologia
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"