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Patrice cani

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https://www.readbyqxmd.com/read/29906245/the-gut-microbiota-metabolite-indole-alleviates-liver-inflammation-in-mice
#1
Martin Beaumont, Audrey M Neyrinck, Marta Olivares, Julie Rodriguez, Audrey de Rocca Serra, Martin Roumain, Laure B Bindels, Patrice D Cani, Pieter Evenepoel, Giulio G Muccioli, Jean-Baptiste Demoulin, Nathalie M Delzenne
The gut microbiota regulates key hepatic functions, notably through the production of bacterial metabolites that are transported via the portal circulation. We evaluated the effects of metabolites produced by the gut microbiota from aromatic amino acids (phenylacetate, benzoate, p-cresol, and indole) on liver inflammation induced by bacterial endotoxin. Precision-cut liver slices prepared from control mice, Kupffer cell (KC)-depleted mice, and obese mice ( ob/ ob) were treated with or without LPS and bacterial metabolites...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29896158/prebiotics-supplementation-impact-on-the-reinforcing-and-motivational-aspect-of-feeding
#2
Anne-Sophie Delbès, Julien Castel, Raphaël G P Denis, Chloé Morel, Mar Quiñones, Amandine Everard, Patrice D Cani, Florence Massiera, Serge H Luquet
Energy homeostasis is tightly regulated by the central nervous system which responds to nervous and circulating inputs to adapt food intake and energy expenditure. However, the rewarding and motivational aspect of food is tightly dependent of dopamine (DA) release in mesocorticolimbic (MCL) system and could be operant in uncontrolled caloric intake and obesity. Accumulating evidence indicate that manipulating the microbiota-gut-brain axis through prebiotic supplementation can have beneficial impact of the host appetite and body weight...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29844585/gut-microbiota-mediated-inflammation-in-obesity-a-link-with-gastrointestinal-cancer
#3
REVIEW
Patrice D Cani, Benedicte F Jordan
Overweight and obesity are associated with increased risk of developing metabolic disorders such as diabetes and cardiovascular diseases. However, besides these metabolic diseases, excess body weight is also associated with different cancers, including gastrointestinal cancers, such as liver, pancreatic and colon cancers. Inflammation is a common feature of both obesity and cancer; however, the origin of this inflammation has been largely debated. Over the past decade, growing evidence has shown that the composition of the gut microbiota and its activity might be associated not only with the onset of inflammation but also with metabolic disorders and cancer...
May 29, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29797022/the-dpp-4-inhibitor-vildagliptin-impacts-the-gut-microbiota-and-prevents-disruption-of-intestinal-homeostasis-induced-by-a-western-diet-in-mice
#4
Marta Olivares, Audrey M Neyrinck, Sarah A Pötgens, Martin Beaumont, Nuria Salazar, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne
AIMS/HYPOTHESIS: Dipeptidyl peptidase 4 (DPP-4) inhibitors are agents designed to increase the half-life of incretins. Although they are administered orally, little is known about their effects on the gut microbiota and functions, despite the fact that some bacteria present in the gut microbiota exhibit DPP-4-like activity. Our objective was to study the impact of the DPP-4 inhibitor vildagliptin on gut functions and the intestinal ecosystem in a murine model of obesity induced by a Western diet (WD)...
May 25, 2018: Diabetologia
https://www.readbyqxmd.com/read/29793999/the-transplantation-of-%C3%AF-3-pufa-altered-gut-microbiota-of-fat-1-mice-to-wild-type-littermates-prevents-obesity-and-associated-metabolic-disorders
#5
Célia Bidu, Quentin Escoula, Sandrine Bellenger, Aymé Spor, Maxime Galan, Audrey Geissler, André Bouchot, Dominique Dardevet, Béatrice Morio-Liondor, Patrice D Cani, Laurent Lagrost, Michel Narce, Jérome Bellenger
Altering the gut microbiome may be beneficial to the host, and it recently arose as a promising strategy to manage obesity. Here, we investigated the relative contribution of ω3 polyunsaturated fatty acid (PUFA)-mediated alterations in the microbiota to metabolic parameter changes in mice. Four groups were compared: male fat-1 transgenic mice (with constitutive production of ω3 PUFAs) and male WT littermates fed either an obesogenic (high fat/high sucrose, HFHS) or a control diet. Unlike WT mice, HFHS-fed fat-1 mice were protected against obesity, glucose intolerance and hepatic steatosis...
May 23, 2018: Diabetes
https://www.readbyqxmd.com/read/29719601/increased-gut-permeability-in-cancer-cachexia-mechanisms-and-clinical-relevance
#6
Laure B Bindels, Audrey M Neyrinck, Audrey Loumaye, Emilie Catry, Hannah Walgrave, Claire Cherbuy, Sophie Leclercq, Matthias Van Hul, Hubert Plovier, Barbara Pachikian, Luis G Bermúdez-Humarán, Philippe Langella, Patrice D Cani, Jean-Paul Thissen, Nathalie M Delzenne
Intestinal disorders often occur in cancer patients, in association with body weight loss, and this alteration is commonly attributed to the chemotherapy. Here, using a mouse model of cancer cachexia induced by ectopic transplantation of C26 cancer cells, we discovered a profound alteration in the gut functions (gut permeability, epithelial turnover, gut immunity, microbial dysbiosis) independently of any chemotherapy. These alterations occurred independently of anorexia and were driven by interleukin 6. Gut dysfunction was found to be resistant to treatments with an anti-inflammatory bacterium ( Faecalibacterium prausnitzii ) or with gut peptides involved in intestinal cell renewal (teduglutide, a glucagon-like peptide 2 analogue)...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29693598/inulin-improves-postprandial-hypertriglyceridemia-by-modulating-gene-expression-in-the-small-intestine
#7
Sophie Hiel, Audrey M Neyrinck, Julie Rodriguez, Barbara D Pachikian, Caroline Bouzin, Jean-Paul Thissen, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne
Postprandial hyperlipidemia is an important risk factor for cardiovascular diseases in the context of obesity. Inulin is a non-digestible carbohydrate, known for its beneficial properties in metabolic disorders. We investigated the impact of inulin on postprandial hypertriglyceridemia and on lipid metabolism in a mouse model of diet-induced obesity. Mice received a control or a western diet for 4 weeks and were further supplemented or not with inulin for 2 weeks (0.2 g/day per mouse). We performed a lipid tolerance test, measured mRNA expression of genes involved in postprandial lipid metabolism, assessed post-heparin plasma and muscle lipoprotein lipase activity and measured lipid accumulation in the enterocytes and fecal lipid excretion...
April 25, 2018: Nutrients
https://www.readbyqxmd.com/read/29687645/gut-microbes-and-health-a-focus-on-the-mechanisms-linking-microbes-obesity-and-related-disorders
#8
REVIEW
Marialetizia Rastelli, Claude Knauf, Patrice D Cani
The past decade has been characterized by tremendous progress in the field of the gut microbiota and its impact on host metabolism. Although numerous studies show a strong relationship between the composition of gut microbiota and specific metabolic disorders associated with obesity, the key mechanisms are still being studied. The present review focuses on specific complex pathways as well as key interactions. For instance, the nervous routes are explored by examining the enteric nervous system, the vagus nerve, and the brain, as well as the endocrine routes (i...
May 2018: Obesity
https://www.readbyqxmd.com/read/29611319/fecal-enterobacteriales-enrichment-is-associated-with-increased-in-vivo-intestinal-permeability-in-humans
#9
Camilla Pedersen, Umer Z Ijaz, Edith Gallagher, Felicity Horton, Richard J Ellis, Etana Jaiyeola, Thibaut Duparc, David Russell-Jones, Paul Hinton, Patrice D Cani, Roberto M La Ragione, M Denise Robertson
Type 2 diabetes (T2D) has been linked with increased intestinal permeability, but the clinical significance of this phenomenon remains unknown. The objective of this study was to investigate the potential link between glucose control, intestinal permeability, diet and intestinal microbiota in patients with T2D. Thirty-two males with well-controlled T2D and 30 age-matched male controls without diabetes were enrolled in a case-control study. Metabolic parameters, inflammatory markers, endotoxemia, and intestinal microbiota in individuals subdivided into high (HP) and normal (LP) colonic permeability groups, were the main outcomes...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29549311/wheat-derived-arabinoxylan-oligosaccharides-with-bifidogenic-properties-abolishes-metabolic-disorders-induced-by-western-diet-in-mice
#10
Audrey M Neyrinck, Sophie Hiel, Caroline Bouzin, Vicenta Garcia Campayo, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne
BACKGROUND: Non-digestible carbohydrates present in cereals such as fructans and arabinoxylans represent promising prebiotic nutrients to prevent the development of obesity and related metabolic disorders. OBJECTIVE AND DESIGN:  The aim of this study was to determine the corrective effects of wheat bran-derived arabinoxylan oligosaccharides in obese mice fed a western diet (WD). WD was given for 4 weeks before wheat bran extract (WBE) supplementation (5%) for an additional 4 weeks, whereas a control group received the standard diet...
March 7, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29428595/galanin-enhances-systemic-glucose-metabolism-through-enteric-nitric-oxide-synthase-expressed-neurons
#11
Anne Abot, Alexandre Lucas, Tereza Bautzova, Arnaud Bessac, Audren Fournel, Sophie Le-Gonidec, Philippe Valet, Cédric Moro, Patrice D Cani, Claude Knauf
OBJECTIVE: Decreasing duodenal contraction is now considered as a major focus for the treatment of type 2 diabetes. Therefore, identifying bioactive molecules able to target the enteric nervous system, which controls the motility of intestinal smooth muscle cells, represents a new therapeutic avenue. For this reason, we chose to study the impact of oral galanin on this system in diabetic mice. METHODS: Enteric neurotransmission, duodenal contraction, glucose absorption, modification of gut-brain axis, and glucose metabolism (glucose tolerance, insulinemia, glucose entry in tissue, hepatic glucose metabolism) were assessed...
April 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29389988/implication-of-trans-11-trans-13-conjugated-linoleic-acid-in-the-development-of-hepatic-steatosis
#12
Barbara D Pachikian, Céline Druart, Emilie Catry, Laure B Bindels, Audrey M Neyrinck, Yvan Larondelle, Patrice D Cani, Nathalie M Delzenne
SCOPE: Conjugated linoleic acids are linoleic acid isomers found in the diet that can also be produced through bacterial metabolism of polyunsaturated fatty acids. Our objective was to evaluate the contribution of fatty acid metabolites produced from polyunsaturated fatty acids by the gut microbiota in vivo to regulation of hepatic lipid metabolism and steatosis. METHODS AND RESULTS: In mice with depleted n-3 polyunsaturated fatty acids, we observed an accumulation of trans-11,trans-13 CLA and cis-9,cis-11 conjugated linoleic acids in the liver tissue that were associated with an increased triglyceride content and expression of lipogenic genes...
2018: PloS One
https://www.readbyqxmd.com/read/29226685/size-effect-on-lipid-nanocapsule-mediated-glp-1-secretion-from-enteroendocrine-l-cells
#13
Yining Xu, Dario Carradori, Mireille Alhouayek, Giulio G Muccioli, Patrice D Cani, Véronique Préat, Ana Beloqui
L cells are enteroendocrine cells located throughout the gastrointestinal tract that secrete physiologically important peptides. The most characterized peptides secreted by L cells are the peptide YY (PYY) and the glucagon-like peptides 1 (GLP-1) and 2 (GLP-2). These peptides are released rapidly into the circulation after oral nutrient ingestion. Recently, lipid-based nanoparticles (NP) have been described as triggers for GLP-1 secretion by L cells. NP physicochemical properties play a key role in the NP-cell interaction, and drive NP cell internalization...
January 2, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29188139/adipose-tissue-metabolism-and-cancer-progression-novel-insights-from-gut-microbiota
#14
REVIEW
Benedicte F Jordan, Florian Gourgue, Patrice D Cani
Purpose of Review: Obesity is strongly associated with the development of several types of cancers. This review aims to discuss the recent key mechanisms and actors underlying the link between adipose tissue metabolism and cancer, and the unequivocal common mechanisms connecting gut microbes to adipose tissue and eventually cancer development. Recent Findings: Complex interactions among systemic and tissue-specific pathways are suggested to link obesity and cancer, involving endocrine hormones, adipokines, fatty acids, inflammation, metabolic alterations, and hypoxia...
2017: Current Pathobiology Reports
https://www.readbyqxmd.com/read/29166392/intestinal-ralstonia-pickettii-augments-glucose-intolerance-in-obesity
#15
Shanthadevi D Udayappan, Petia Kovatcheva-Datchary, Guido J Bakker, Stefan R Havik, Hilde Herrema, Patrice D Cani, Kristien E Bouter, Clara Belzer, Julia J Witjes, Anne Vrieze, Eleanore Susanne Victoria de Sonnaville, Alice Chaplin, Daniel H van Raalte, Steven Aalvink, Geesje M Dallinga-Thie, Hans G H J Heilig, Göran Bergström, Suzan van der Meij, Bart A van Wagensveld, Joost B L Hoekstra, Frits Holleman, Erik S G Stroes, Albert K Groen, Fredrik Bäckhed, Willem M de Vos, Max Nieuwdorp
An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. Here, we report that bacterial DNA is present in mesenteric adipose tissue of obese but otherwise healthy human subjects. Pyrosequencing of bacterial 16S rRNA genes revealed that DNA from the Gram-negative species Ralstonia was most prevalent...
2017: PloS One
https://www.readbyqxmd.com/read/29107285/host-microbiota-interaction-induces-bi-phasic-inflammation-and-glucose-intolerance-in-mice
#16
Antonio Molinaro, Robert Caesar, Louise Mannerås Holm, Valentina Tremaroli, Patrice D Cani, Fredrik Bäckhed
OBJECTIVE: Gut microbiota modulates adiposity and glucose metabolism in humans and mice. Here we investigated how colonization of germ-free (GF) mice affects kinetics of adiposity and glucose metabolism. METHODS: Adiposity and glucose metabolism were evaluated at different time points in ex-GF and antibiotic treated mice after colonization with gut microbiota from a conventionally raised (CONV-R) mouse. Mouse physiology, microbiome configuration, serum cytokine levels, and gene expression for inflammatory markers were performed in different tissues...
November 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29024086/combined-endogenous-mr-biomarkers-to-predict-basal-tumor-oxygenation-and-response-to-hyperoxic-challenge
#17
Thanh-Trang Cao-Pham, Nicolas Joudiou, Matthias Van Hul, Caroline Bouzin, Patrice D Cani, Bernard Gallez, Bénédicte F Jordan
Hypoxia is a common feature of solid tumors, which translates into increased angiogenesis, malignant phenotype cell selection, change in gene expression and greater resistance to radiotherapy and chemotherapy. Therefore, there is a need for markers of hypoxia to stratify patients, in order to personalize treatment to improve therapeutic outcome. However, no modality has yet been validated for the screening of hypoxia in routine clinical practice. Magnetic resonance imaging (MRI) R1 and R2 * relaxation parameters are sensitive to tissue oxygenation: R1 is sensitive to dissolved oxygen and R2 * is sensitive to intravascular deoxyhemoglobin content...
October 11, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29018410/next-generation-beneficial-microbes-the-case-of-akkermansia-muciniphila
#18
REVIEW
Patrice D Cani, Willem M de Vos
Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide epidemic. Among the different environmental factors, the gut microbiota is now considered as a key player interfering with energy metabolism and host susceptibility to several non-communicable diseases. Among the next-generation beneficial microbes that have been identified, Akkermansia muciniphila is a promising candidate. Indeed, A. muciniphila is inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28906350/the-hundred-most-cited-publications-in-microbiota-of-diabetes-research-a-bibliometric-analysis
#19
Jiaxing Tian, Min Li, Fengmei Lian, Xiaolin Tong
BACKGROUND: Bibliometric analysis is an approach to evaluate the circumstances and trends in specific research field over time and to provide inspiration in future research and policy. Researches have a tremendous increase focus on the role of the microbiota in the development of diabetes in recent years; however, there is no published literature conducting a bibliometric analysis to explore the tendency. The aim of this study was to provide a detailed evaluation of the hundred most cited articles in microbiota of diabetes research...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28898875/enteroendocrine-cells-metabolic-relays-between-microbes-and-their-host
#20
REVIEW
Hubert Plovier, Patrice D Cani
Gut bacteria exert a variety of metabolic functions unavailable to the host and are increasingly seen as a virtual organ located inside our gastrointestinal tract. Scattered in our intestinal epithelium, enteroendocrine cells (EECs) regulate several aspects of the host's physiology and translate signals coming from the gut microbiota through their hormonal secretions. In this chapter, we will assess the interplay between the gut microbiota and EEC and its consequences for the physiology of the host. We will first describe alterations of different populations of EEC in germ-free animals...
2017: Endocrine Development
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