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Patrice cani

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https://www.readbyqxmd.com/read/29693598/inulin-improves-postprandial-hypertriglyceridemia-by-modulating-gene-expression-in-the-small-intestine
#1
Sophie Hiel, Audrey M Neyrinck, Julie Rodriguez, Barbara D Pachikian, Caroline Bouzin, Jean-Paul Thissen, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne
Postprandial hyperlipidemia is an important risk factor for cardiovascular diseases in the context of obesity. Inulin is a non-digestible carbohydrate, known for its beneficial properties in metabolic disorders. We investigated the impact of inulin on postprandial hypertriglyceridemia and on lipid metabolism in a mouse model of diet-induced obesity. Mice received a control or a western diet for 4 weeks and were further supplemented or not with inulin for 2 weeks (0.2 g/day per mouse). We performed a lipid tolerance test, measured mRNA expression of genes involved in postprandial lipid metabolism, assessed post-heparin plasma and muscle lipoprotein lipase activity and measured lipid accumulation in the enterocytes and fecal lipid excretion...
April 25, 2018: Nutrients
https://www.readbyqxmd.com/read/29687645/gut-microbes-and-health-a-focus-on-the-mechanisms-linking-microbes-obesity-and-related-disorders
#2
REVIEW
Marialetizia Rastelli, Claude Knauf, Patrice D Cani
The past decade has been characterized by tremendous progress in the field of the gut microbiota and its impact on host metabolism. Although numerous studies show a strong relationship between the composition of gut microbiota and specific metabolic disorders associated with obesity, the key mechanisms are still being studied. The present review focuses on specific complex pathways as well as key interactions. For instance, the nervous routes are explored by examining the enteric nervous system, the vagus nerve, and the brain, as well as the endocrine routes (i...
May 2018: Obesity
https://www.readbyqxmd.com/read/29611319/fecal-enterobacteriales-enrichment-is-associated-with-increased-in-vivo-intestinal-permeability-in-humans
#3
Camilla Pedersen, Umer Z Ijaz, Edith Gallagher, Felicity Horton, Richard J Ellis, Etana Jaiyeola, Thibaut Duparc, David Russell-Jones, Paul Hinton, Patrice D Cani, Roberto M La Ragione, M Denise Robertson
Type 2 diabetes (T2D) has been linked with increased intestinal permeability, but the clinical significance of this phenomenon remains unknown. The objective of this study was to investigate the potential link between glucose control, intestinal permeability, diet and intestinal microbiota in patients with T2D. Thirty-two males with well-controlled T2D and 30 age-matched male controls without diabetes were enrolled in a case-control study. Metabolic parameters, inflammatory markers, endotoxemia, and intestinal microbiota in individuals subdivided into high (HP) and normal (LP) colonic permeability groups, were the main outcomes...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29549311/wheat-derived-arabinoxylan-oligosaccharides-with-bifidogenic-properties-abolishes-metabolic-disorders-induced-by-western-diet-in-mice
#4
Audrey M Neyrinck, Sophie Hiel, Caroline Bouzin, Vicenta Garcia Campayo, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne
BACKGROUND: Non-digestible carbohydrates present in cereals such as fructans and arabinoxylans represent promising prebiotic nutrients to prevent the development of obesity and related metabolic disorders. OBJECTIVE AND DESIGN:  The aim of this study was to determine the corrective effects of wheat bran-derived arabinoxylan oligosaccharides in obese mice fed a western diet (WD). WD was given for 4 weeks before wheat bran extract (WBE) supplementation (5%) for an additional 4 weeks, whereas a control group received the standard diet...
March 7, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29428595/galanin-enhances-systemic-glucose-metabolism-through-enteric-nitric-oxide-synthase-expressed-neurons
#5
Anne Abot, Alexandre Lucas, Tereza Bautzova, Arnaud Bessac, Audren Fournel, Sophie Le-Gonidec, Philippe Valet, Cédric Moro, Patrice D Cani, Claude Knauf
OBJECTIVE: Decreasing duodenal contraction is now considered as a major focus for the treatment of type 2 diabetes. Therefore, identifying bioactive molecules able to target the enteric nervous system, which controls the motility of intestinal smooth muscle cells, represents a new therapeutic avenue. For this reason, we chose to study the impact of oral galanin on this system in diabetic mice. METHODS: Enteric neurotransmission, duodenal contraction, glucose absorption, modification of gut-brain axis, and glucose metabolism (glucose tolerance, insulinemia, glucose entry in tissue, hepatic glucose metabolism) were assessed...
January 31, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29389988/implication-of-trans-11-trans-13-conjugated-linoleic-acid-in-the-development-of-hepatic-steatosis
#6
Barbara D Pachikian, Céline Druart, Emilie Catry, Laure B Bindels, Audrey M Neyrinck, Yvan Larondelle, Patrice D Cani, Nathalie M Delzenne
SCOPE: Conjugated linoleic acids are linoleic acid isomers found in the diet that can also be produced through bacterial metabolism of polyunsaturated fatty acids. Our objective was to evaluate the contribution of fatty acid metabolites produced from polyunsaturated fatty acids by the gut microbiota in vivo to regulation of hepatic lipid metabolism and steatosis. METHODS AND RESULTS: In mice with depleted n-3 polyunsaturated fatty acids, we observed an accumulation of trans-11,trans-13 CLA and cis-9,cis-11 conjugated linoleic acids in the liver tissue that were associated with an increased triglyceride content and expression of lipogenic genes...
2018: PloS One
https://www.readbyqxmd.com/read/29226685/size-effect-on-lipid-nanocapsule-mediated-glp-1-secretion-from-enteroendocrine-l-cells
#7
Yining Xu, Dario Carradori, Mireille Alhouayek, Giulio G Muccioli, Patrice D Cani, Véronique Préat, Ana Beloqui
L cells are enteroendocrine cells located throughout the gastrointestinal tract that secrete physiologically important peptides. The most characterized peptides secreted by L cells are the peptide YY (PYY) and the glucagon-like peptides 1 (GLP-1) and 2 (GLP-2). These peptides are released rapidly into the circulation after oral nutrient ingestion. Recently, lipid-based nanoparticles (NP) have been described as triggers for GLP-1 secretion by L cells. NP physicochemical properties play a key role in the NP-cell interaction, and drive NP cell internalization...
January 2, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29188139/adipose-tissue-metabolism-and-cancer-progression-novel-insights-from-gut-microbiota
#8
REVIEW
Benedicte F Jordan, Florian Gourgue, Patrice D Cani
Purpose of Review: Obesity is strongly associated with the development of several types of cancers. This review aims to discuss the recent key mechanisms and actors underlying the link between adipose tissue metabolism and cancer, and the unequivocal common mechanisms connecting gut microbes to adipose tissue and eventually cancer development. Recent Findings: Complex interactions among systemic and tissue-specific pathways are suggested to link obesity and cancer, involving endocrine hormones, adipokines, fatty acids, inflammation, metabolic alterations, and hypoxia...
2017: Current Pathobiology Reports
https://www.readbyqxmd.com/read/29166392/intestinal-ralstonia-pickettii-augments-glucose-intolerance-in-obesity
#9
Shanthadevi D Udayappan, Petia Kovatcheva-Datchary, Guido J Bakker, Stefan R Havik, Hilde Herrema, Patrice D Cani, Kristien E Bouter, Clara Belzer, Julia J Witjes, Anne Vrieze, Eleanore Susanne Victoria de Sonnaville, Alice Chaplin, Daniel H van Raalte, Steven Aalvink, Geesje M Dallinga-Thie, Hans G H J Heilig, Göran Bergström, Suzan van der Meij, Bart A van Wagensveld, Joost B L Hoekstra, Frits Holleman, Erik S G Stroes, Albert K Groen, Fredrik Bäckhed, Willem M de Vos, Max Nieuwdorp
An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. Here, we report that bacterial DNA is present in mesenteric adipose tissue of obese but otherwise healthy human subjects. Pyrosequencing of bacterial 16S rRNA genes revealed that DNA from the Gram-negative species Ralstonia was most prevalent...
2017: PloS One
https://www.readbyqxmd.com/read/29107285/host-microbiota-interaction-induces-bi-phasic-inflammation-and-glucose-intolerance-in-mice
#10
Antonio Molinaro, Robert Caesar, Louise Mannerås Holm, Valentina Tremaroli, Patrice D Cani, Fredrik Bäckhed
OBJECTIVE: Gut microbiota modulates adiposity and glucose metabolism in humans and mice. Here we investigated how colonization of germ-free (GF) mice affects kinetics of adiposity and glucose metabolism. METHODS: Adiposity and glucose metabolism were evaluated at different time points in ex-GF and antibiotic treated mice after colonization with gut microbiota from a conventionally raised (CONV-R) mouse. Mouse physiology, microbiome configuration, serum cytokine levels, and gene expression for inflammatory markers were performed in different tissues...
November 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29024086/combined-endogenous-mr-biomarkers-to-predict-basal-tumor-oxygenation-and-response-to-hyperoxic-challenge
#11
Thanh-Trang Cao-Pham, Nicolas Joudiou, Matthias Van Hul, Caroline Bouzin, Patrice D Cani, Bernard Gallez, Bénédicte F Jordan
Hypoxia is a common feature of solid tumors, which translates into increased angiogenesis, malignant phenotype cell selection, change in gene expression and greater resistance to radiotherapy and chemotherapy. Therefore, there is a need for markers of hypoxia to stratify patients, in order to personalize treatment to improve therapeutic outcome. However, no modality has yet been validated for the screening of hypoxia in routine clinical practice. Magnetic resonance imaging (MRI) R1 and R2 * relaxation parameters are sensitive to tissue oxygenation: R1 is sensitive to dissolved oxygen and R2 * is sensitive to intravascular deoxyhemoglobin content...
October 11, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29018410/next-generation-beneficial-microbes-the-case-of-akkermansia-muciniphila
#12
REVIEW
Patrice D Cani, Willem M de Vos
Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide epidemic. Among the different environmental factors, the gut microbiota is now considered as a key player interfering with energy metabolism and host susceptibility to several non-communicable diseases. Among the next-generation beneficial microbes that have been identified, Akkermansia muciniphila is a promising candidate. Indeed, A. muciniphila is inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28906350/the-hundred-most-cited-publications-in-microbiota-of-diabetes-research-a-bibliometric-analysis
#13
Jiaxing Tian, Min Li, Fengmei Lian, Xiaolin Tong
BACKGROUND: Bibliometric analysis is an approach to evaluate the circumstances and trends in specific research field over time and to provide inspiration in future research and policy. Researches have a tremendous increase focus on the role of the microbiota in the development of diabetes in recent years; however, there is no published literature conducting a bibliometric analysis to explore the tendency. The aim of this study was to provide a detailed evaluation of the hundred most cited articles in microbiota of diabetes research...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28898875/enteroendocrine-cells-metabolic-relays-between-microbes-and-their-host
#14
Hubert Plovier, Patrice D Cani
Gut bacteria exert a variety of metabolic functions unavailable to the host and are increasingly seen as a virtual organ located inside our gastrointestinal tract. Scattered in our intestinal epithelium, enteroendocrine cells (EECs) regulate several aspects of the host's physiology and translate signals coming from the gut microbiota through their hormonal secretions. In this chapter, we will assess the interplay between the gut microbiota and EEC and its consequences for the physiology of the host. We will first describe alterations of different populations of EEC in germ-free animals...
2017: Endocrine Development
https://www.readbyqxmd.com/read/28874357/reduced-obesity-diabetes-and-steatosis-upon-cinnamon-and-grape-pomace-are-associated-with-changes-in-gut-microbiota-and-markers-of-gut-barrier
#15
Matthias Van Hul, Lucie Geurts, Hubert Plovier, Céline Druart, Amandine Everard, Marcus Ståhlman, Moez Rhimi, Kleopatra Chira, Pierre-Louis Teissedre, Nathalie M Delzenne, Emmanuelle Maguin, Angèle Guilbot, Amandine Brochot, Philippe Gérard, Fredrik Bäckhed, Patrice D Cani
Increasing evidence suggests that polyphenols have a significant potential in the prevention and treatment of risk factors associated with metabolic syndrome. The objective of this study was to assess the metabolic outcomes of two polyphenol-containing extracts from cinnamon bark (CBE) and grape pomace (GPE) on C57BL/6J mice fed a high-fat diet (HFD) for 8 wk. Both CBE and GPE were able to decrease fat mass gain and adipose tissue inflammation in mice fed a HFD without reducing food intake. This was associated with reduced liver steatosis and lower plasma nonesterified fatty acid levels...
April 1, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28873082/ffar2-expression-regulates-leukaemic-cell-growth-in-vivo
#16
Laure B Bindels, Paolo E Porporato, Sarah Ducastel, Martina Sboarina, Audrey M Neyrinck, Evelyne M Dewulf, Olivier Feron, Sophie Lestavel, Patrice D Cani, Bart Staels, Pierre Sonveaux, Nathalie M Delzenne
BACKGROUND: Activation of free fatty acid receptor 2 (FFAR2) by microbiota-derived metabolites (e.g., propionate) reduces leukaemic cell proliferation in vitro. This study aims to test whether Ffar2 expression per se also influences leukaemia cell growth in vivo. METHODS: Bcr-Abl-expressing BaF cells were used as a leukaemia model and the role of Ffar2 was evaluated in Balb/c mice after lentiviral shRNA transduction. RESULTS: Our data formally establish that reduced leukaemic cell proliferation is associated with increased Ffar2 expression in vivo and in vitro...
October 24, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28863365/a-polyphenolic-extract-from-green-tea-leaves-activates-fat-browning-in-high-fat-diet-induced-obese-mice
#17
Audrey M Neyrinck, Laure B Bindels, Lucie Geurts, Matthias Van Hul, Patrice D Cani, Nathalie M Delzenne
Fat browning has emerged as an attractive target for the treatment of obesity and related metabolic disorders. Its activation leads to increased energy expenditure and reduced adiposity, thus contributing to a better energy homeostasis. Green tea extracts (GTEs) were shown to attenuate obesity and low-grade inflammation and to induce the lipolytic pathway in the white adipose tissue (WAT) of mice fed a high-fat diet. The aim of the present study was to determine whether the antiobesity effect of an extract from green tea leaves was associated with the activation of browning in the WAT and/or the inhibition of whitening in the brown adipose tissue (BAT) in HF-diet induced obese mice...
November 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28798116/gut-cell-metabolism-shapes-the-microbiome
#18
COMMENT
Patrice D Cani
No abstract text is available yet for this article.
August 11, 2017: Science
https://www.readbyqxmd.com/read/28717237/fat-binding-capacity-and-modulation-of-the-gut-microbiota-both-determine-the-effect-of-wheat-bran-fractions-on-adiposity
#19
Francesco Suriano, Laure B Bindels, Joran Verspreet, Christophe M Courtin, Kristin Verbeke, Patrice D Cani, Audrey M Neyrinck, Nathalie M Delzenne
The aim of this study was to determine the impact of different wheat bran fractions on the gut microbiota and fat binding capacity to explain their differential effects on metabolic and inflammatory disorders induced by a western diet (WD) in mice. Wheat bran derived arabinoxylan oligosaccharides (AXOS), a crude fraction of wheat bran (WB), or the same wheat bran with reduced particle size (WBs) were added to the WD of mice for 8 weeks. AXOS shifted the gut microbiota composition, blunted Clostridium and Turicibacter genera and strongly promoted Bifidobacterium and Butyricicoccus genera, independently of changes in gut antimicrobial peptide expression...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28632181/spirulina-protects-against-hepatic-inflammation-in-aging-an-effect-related-to-the-modulation-of-the-gut-microbiota
#20
Audrey M Neyrinck, Bernard Taminiau, Hannah Walgrave, Georges Daube, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne
Aging predisposes to hepatic dysfunction and inflammation that can contribute to the development of non-alcoholic fatty liver disease. Spirulina, a cyanobacterium used as a food additive or food supplement, has been shown to impact immune function. We have tested the potential hepatoprotective effect of a Spirulina in aged mice and to determine whether these effects can be related to a modulation of the gut microbiota. Old mice have been fed a standard diet supplemented with or without 5% Spirulina for six weeks...
June 20, 2017: Nutrients
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