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Depression symptoms

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https://www.readbyqxmd.com/read/29040947/a-6-week-multicenter-double-blind-double-dummy-chlorpromazine-controlled-non-inferiorityrandomized-phase-iiitrial-to-evaluate-the-efficacy-and-safety-of-quetiapine-fumarate-seroquel-extended-release-xr-in-the-treatment-of-patients-with-schizophrenia-and-acute
#1
Huafang Li, Yifeng Shen, Gang Wang, Jianguo Shi, Cui Ma, Shiping Xie, Honggeng Zhang, Xiaoping Wang, Keqing Li, Xiufeng Xu, Niufan Gu
This study aimed to evaluate the efficacy and safety of quetiapine fumarate extended-release (XR) in the treatment of Chinese patients with acute schizophrenia. Multicenter, double-blind, double-dummy, active-controlled non-inferiority randomized study in Chinese patients (n = 388) with schizophrenia randomly assigned to quetiapine XR or chlorpromazine for 6 weeks. Primary outcome was the change from baseline in Positive and Negative Syndrome Scale (PANSS) total score at the end of treatment. Safety objectives included adverse event (AE) monitoring, laboratory test results, and electrocardiograms...
July 22, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29040650/interferon-alpha-reduces-human-hippocampal-neurogenesis-and-increases-apoptosis-via-activation-of-distinct-stat1-dependent-mechanisms
#2
Alessandra Borsini, Annamaria Cattaneo, Chiara Malpighi, Sandrine Thuret, Neil A Harrison, Patricia A Zunszain, Carmine M Pariante
Background: In humans, interferon-α treatment for chronic viral hepatitis is a well-recognized clinical model for inflammation-induced depression, but the molecular mechanisms underlying these effects are not clear. Following peripheral administration in rodents, interferon-α induces signal transducer and activator of transcription-1 (STAT1) within the hippocampus and disrupts hippocampal neurogenesis. Methods: We used the human hippocampal progenitor cell line HPC0A07/03C to evaluate the effects of 2 concentrations of interferon-α, similar to those observed in human serum during its therapeutic use (500 pg/mL and 5000 pg/mL), on neurogenesis and apoptosis...
October 10, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29040216/depressive-symptoms-screening-in-postmenopausal-women-with-symptomatic-pelvic-organ-prolapse
#3
Fangfang Ai, Mou Deng, Meng Mao, Tao Xu, Lan Zhu
OBJECTIVE: This study aimed to investigate the prevalence of depressive symptoms in postmenopausal women with symptomatic pelvic organ prolapse (POP) and to identify the factors associated with depressive symptoms in this population. METHODS: We conducted a cross-sectional study involving postmenopausal women with symptomatic POP who visited the Center of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, between July 2016 and March 2017...
October 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29036833/gsk3%C3%AE-aggravates-the-depression-symptoms-in-chronic-stress-mouse-model
#4
Hong Peng, Hong-Bin Wang, Ling Wang, Bing Zhou, Xiao-Yong Li, Jian Tan
Depression caused by genetic and environmental factors is a kind of complicated disease. Here, we find that Gsk3β is highly expressed and phosphorylated in the brain of chronic stress mouse. Inhibition of Gsk3β lead to decreased depression like symptoms which is manifested in open field test, tail-suspension test, forced-swim test and novelty suppressed feeding test. Besides, accompanied by activated Gsk3β, we find that β-catenin is attenuated, and its target genes Cyclin D1 and c-Myc are down-regulated...
October 13, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29036587/latent-profile-analysis-and-conversion-to-psychosis-characterizing-subgroups-to-enhance-risk-prediction
#5
Kristin M Healey, David L Penn, Diana Perkins, Scott W Woods, Richard S E Keefe, Jean Addington
BACKGROUND: Groups at clinical high risk (CHR) of developing psychosis are heterogeneous, composed of individuals with different clusters of symptoms. It is likely that there exist subgroups, each associated with different symptom constellations and probabilities of conversion. METHOD: Present study used latent profile analysis (LPA) to ascertain subgroups in a combined sample of CHR (n = 171) and help-seeking controls (HSCs; n = 100; PREDICT study). Indicators in the LPA model included baseline Scale of Prodromal Symptoms (SOPS), Calgary Depression Scale for Schizophrenia (CDSS), and neurocognitive performance as measured by multiple instruments, including category instances (CAT)...
July 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036388/risk-factors-for-suicidality-in-patients-with-schizophrenia-a-systematic-review-meta-analysis-and-meta-regression-of-96-studies
#6
Ryan Michael Cassidy, Fang Yang, Flávio Kapczinski, Ives Cavalcante Passos
The lifetime risk of suicide and suicide attempt in patients with schizophrenia are 5% and 25%-50%, respectively. The current meta-analysis aims to determine risk factors associated with suicidality in subjects with schizophrenia. We searched Pubmed, Web of Science, EMBASE, and the reference lists of included studies. Inclusion criteria were met if an article reported a dichotomous sample of patients with schizophrenia with suicidal ideation, attempted suicide, or suicide compared to patients without. We also performed a cohort study meta-analysis as a supplemental analysis...
September 23, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036311/do-work-and-family-care-histories-predict-health-in-older-women
#7
Rebecca Benson, Karen Glaser, Laurie M Corna, Loretta G Platts, Giorgio Di Gessa, Diana Worts, Debora Price, Peggy McDonough, Amanda Sacker
Background: Social and policy changes in the last several decades have increased women's options for combining paid work with family care. We explored whether specific combinations of work and family care over the lifecourse are associated with variations in women's later life health. Methods: We used sequence analysis to group women in the English Longitudinal Study of Ageing according to their work histories and fertility. Using logistic regression, we tested for group differences in later life disability, depressive symptomology and mortality, while controlling for childhood health and socioeconomic position and a range of adult socio-economic circumstances and health behaviours...
September 23, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29036212/dietary-patterns-and-mental-health-after-myocardial-infarction
#8
Nathaly Rius-Ottenheim, Daan Kromhout, Femke P C Sijtsma, Johanna M Geleijnse, Erik J Giltay
BACKGROUND: Diet has been associated with better mental health in general populations, but less is known on this association in patients with a history of coronary heart disease. The objective of this study is to examine the cross-sectional associations between dietary patterns and mental health in elderly patients with a history of myocardial infarction. METHODS: Data were drawn from the final assessment of the Alpha Omega cohort that monitored patients with a history of myocardial infarction (age range 60-80 years)...
2017: PloS One
https://www.readbyqxmd.com/read/29035920/the-antidepressant-like-effects-of-sinomenine-in-mice-a-behavioral-and-neurobiological-characterization
#9
Xiuqin Li, Chao Liu, Bo Jiang, Kai Chen, Wenjuan Li, Hongze Wang
Sinomenine is a bioactive alkaloid extracted from Sinomenium acutum. Here, we investigated the antidepressant effects of sinomenine in mice. The antidepressant actions of sinomenine were first examined in the forced-swim test and the tail-suspension test, and then assessed in the chronic social defeat stress (CSDS) model of depression. Changes in the brain-derived neurotrophic factor (BDNF) signaling pathway after CSDS and sinomenine treatment were also investigated. A tryptophan hydroxylase inhibitor and a BDNF signaling inhibitor were also used to determine the pharmacological mechanisms of sinomenine...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29035800/exploring-mechanisms-of-change-in-schema-therapy-for-chronic-depression
#10
Fritz Renner, Robert DeRubeis, Arnoud Arntz, Frenk Peeters, Jill Lobbestael, Marcus J H Huibers
BACKGROUND AND OBJECTIVES: The underlying mechanisms of symptom change in schema therapy (ST) for chronic major depressive disorder (cMDD) have not been studied. The aim of this study was to explore the impact of two potentially important mechanisms of symptom change, maladaptive schemas (proxied by negative idiosyncratic core-beliefs) and the therapeutic alliance. METHODS: We drew data from a single-case series of ST for cMDD. Patients with cMDD (N = 20) received on average 78 repeated weekly assessments over a course of up to 65 individual sessions of ST...
October 6, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/29035741/association-between-psychological-distress-subjective-cognitive-complaints-and-objective-neuropsychological-functioning-in-brain-tumor-patients
#11
Aiste Pranckeviciene, Vytenis Pranas Deltuva, Arimantas Tamasauskas, Adomas Bunevicius
OBJECTIVES: Psychological distress and cognitive impairment are common complications in patients with brain tumors that are associated with poor quality of life and worse prognosis. This pilot study aimed to evaluate the associations between psychological distress, subjective cognitive complaints and baseline neuropsychological performance of brain tumor patients before neurosurgery. PATIENTS AND METHODS: Sixty-two patients with various brain tumors referred for routine neuropsychological assessment 2-3days before neurosurgery participated in the study...
October 10, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29035730/features-of-mood-associated-with-high-body-weight-in-females-with-fibromyalgia
#12
Alessandra Alciati, Fabiola Atzeni, Massimiliano Grassi, Daniela Caldirola, Piercarlo Sarzi-Puttini, Jules Angst, Giampaolo Perna
BACKGROUND: Fibromyalgia (FM) is a common syndrome whose main characteristic is chronic widespread musculoskeletal pain, the severity of which is frequently worsened by concomitant obesity. Major depression (MD), particularly as part of a bipolar spectrum disorder (BSD), is associated with both obesity and FM. OBJECTIVE: To evaluate the relationship between lifetime MD, hypomanic symptoms and the body mass index (BMI) in patients with FM. METHOD: Of the 115 patients originally screened, 87 women with FM finally entered the study...
September 6, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29035707/clinician-identification-of-elevated-symptoms-of-depression-among-individuals-seeking-treatment-for-substance-misuse
#13
Breanne Hobden, Mariko Carey, Jamie Bryant, Rob Sanson-Fisher, Christopher Oldmeadow
BACKGROUND: Depression is common among those experiencing alcohol and other drug (AOD) disorders. It has been suggested that identifying depressive symptoms among this group is important for case management. Despite this, there is a lack of research examining how well clinicians perform this task within this setting. AIMS: To determine the: (i) accuracy of clinician identified elevated symptoms of depression among clients seeking treatment for AOD misuse as compared to a standardized self-report psychiatric screening tool; and (ii) clinician and client characteristics associated with accurate identification of elevated symptoms of depression...
October 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29035703/a-randomized-clinical-trial-examining-the-effects-of-an-anxiety-sensitivity-intervention-on-insomnia-symptoms-replication-and-extension
#14
Nicole A Short, Joseph W Boffa, Savannah King, Brian J Albanese, Nicholas P Allan, Norman B Schmidt
Insomnia disorder is impairing and prevalent, particularly among individuals with comorbid anxiety disorders. Despite the availability of effective computerized treatments for insomnia, there are few that target both insomnia as well as co-occurring anxiety symptoms. The current study tests the efficacy of a computerized treatment for anxiety sensitivity cognitive concerns, a transdiagnostic risk factor for anxiety, mood, and insomnia symptoms, against a repeated contact control, on reducing insomnia symptoms...
October 5, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29035422/the-use-of-telemedicine-and-mobile-technology-to-promote-population-health-and-population-management-for-psychiatric-disorders
#15
REVIEW
Carolyn Turvey, John Fortney
PURPOSE OF REVIEW: This article discusses recent applications in telemedicine to promote the goals of population health and population management for people suffering psychiatric disorders. RECENT FINDINGS: The use of telemedicine to promote collaborative care, self-monitoring and chronic disease management, and population screening has demonstrated broad applicability and effectiveness. Collaborative care using videoconferencing to facilitate mental health specialty consults has demonstrated effectiveness in the treatment of depression, PTSD, and also ADHD in pediatric populations...
October 16, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29035330/whites-but-not-blacks-gain-life-expectancy-from-social-contacts
#16
Shervin Assari
Background. Recent research suggests that the health gain from economic resources and psychological assets may be systematically larger for Whites than Blacks. Aim. This study aimed to assess whether the life expectancy gain associated with social contacts over a long follow up differs for Blacks and Whites. Methods. Data came from the Americans' Changing Lives (ACL) Study, 1986-2011. The sample was a nationally representative sample of American adults 25 and older, who were followed for up to 25 years (n = 3361)...
October 16, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/29035066/multiple-self-reported-sleep-measures-are-differentially-associated-with-cognitive-performance-in-community-dwelling-nondemented-elderly
#17
John P K Bernstein, Matthew Calamia, Jeffrey N Keller
OBJECTIVE: To examine associations between daytime and insomnia-related sleep problems with different domains of cognitive functioning and determine whether subclinical depressive symptoms and age moderate these associations. METHOD: A total of 903 cognitively healthy older adults enrolled in a longitudinal aging study completed the UDS neuropsychological battery (measuring attention, executive functioning, episodic memory, language and processing speed). Subclinical depressive symptoms were also assessed and self-reported measures of sleep were administered...
October 16, 2017: Neuropsychology
https://www.readbyqxmd.com/read/29034740/efficacy-and-safety-of-the-traditional-herbal-medicine-gamiguibi-tang-in-patients-with-cancer-related-sleep-disturbance-a-prospective-randomized-wait-list-controlled-pilot-study
#18
Jee Young Lee, Hye Kyung Oh, Han Sung Ryu, Sung Soo Yoon, Wankyu Eo, Seong Woo Yoon
BACKGROUND: Sleep disturbance is the second most bothersome symptom in patients with cancer, and it can significantly impair their quality of life. The aim of this study was to investigate the efficacy and safety of the traditional herbal medicine Gamiguibi-tang (GGBT) in patients with cancer-related sleep disturbance. METHODS: We conducted a prospective, randomized, wait-list-controlled, open-label pilot clinical trial on cancer-related sleep disturbance. Patients with cancer experiencing poor sleep quality with a Pittsburgh Sleep Quality Index of at least 6 were randomly assigned to the GGBT and wait-list groups to receive GGBT and conventional care, respectively, for 2 weeks...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29034733/mothers-personal-and-interpersonal-function-as-potential-mediators-between-maternal-maltreatment-history-and-child-behavior-problems
#19
Jessica Pereira, Jaclyn A Ludmer, Andrea Gonzalez, Leslie Atkinson
This study examined maternal depressive symptoms, social support, parenting, and adult attachment as mediators explaining the relation between maternal childhood maltreatment and child behavior in offspring. We assessed a community sample of 96 mother-child dyads. At child age 16 months, mothers self-reported maltreatment history, adult attachment, depressive symptoms, and social support, and maternal sensitivity was assessed via 2 hr of direct behavioral observation. Maternal reports of child behavior were collected at 5 years...
January 1, 2017: Child Maltreatment
https://www.readbyqxmd.com/read/29034720/investigating-the-neuroanatomical-substrate-of-pathological-laughing-and-crying-in-amyotrophic-lateral-sclerosis-with-multimodal-neuroimaging-techniques
#20
Foteini Christidi, Efstratios Karavasilis, Panagiotis Ferentinos, Sophia Xirou, Georgios Velonakis, Michalis Rentzos, Vasiliki Zouvelou, Ioannis Zalonis, Efstathios Efstathopoulos, Nikolaos Kelekis, Ioannis Evdokimidis
OBJECTIVE: Pathological laughing and crying (PLC) is common in several neurological and psychiatric diseases and is associated with a distributed network involving the frontal cortex, the brainstem and cortico-pontine-cerebellar circuits. By applying multimodal neuroimaging approach, we examined the neuroanatomical substrate of PLC in a sample of patients with amyotrophic lateral sclerosis (ALS). METHODS: We studied 56 non-demented ALS patients and 25 healthy controls (HC)...
October 15, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
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