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https://www.readbyqxmd.com/read/27881487/osteogenesis-requires-fak-dependent-collagen-synthesis-by-fibroblasts-and-osteoblasts
#1
Dhaarmini Rajshankar, Yongqiang Wang, Christopher A McCulloch
Focal adhesion kinase (FAK) is critical in adhesion-dependent signaling, but its role in osteogenesis in vivo is ill defined. We deleted Fak in fibroblasts and osteoblasts in Floxed-Fak mice bred with those expressing Cre-recombinase driven by 3.6 kb α1(I)-collagen promoter. Compared with wild-type (WT), conditional FAK-knockout (CFKO) mice were shorter (2-fold; P < 0.0001) and had crooked, shorter tails (50%; P < 0.0001). Microcomputed tomography analysis showed reduced bone volume (4-fold in tails; P < 0...
November 23, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27761392/periosteum-as-a-lateral-pedicle-graft-for-the-treatment-of-single-tooth-root-recession-a-novel-approach
#2
Avadhesh Kumar, Shalini Kaushal, Neelu Verma, Deepti Chandra
The treatment of gingival recession defects is indicated for esthetic and functional reasons to reduce root sensitivity, to remove muscle pull, to create or augment keratinized tissue, and to prevent disease progression. The presence of sufficient amount of periosteum adjacent to gingival recession defects makes it a suitable graft. The adult human periosteum is a highly vascular connective tissue with immense regenerative potential. It contains fibroblasts, osteogenic progenitor cells, and stem cells as a result of which it has the ability to differentiate into fibroblast, osteoblast, chondrocytes, adipocytes, and skeletal myocytes...
September 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27748036/effects-of-diode-laser-irradiation-and-fibroblast-growth-factor-on-periodontal-healing-of-replanted-teeth-after-extended-extra-oral-dry-time
#3
Erica Dos Santos Carvalho, Rogério Hadid Rosa, Flávia de Moura Pereira, Ana Lia Anbinder, Isabel Mello, Sandra Marcia Habitante, Denise Pontes Raldi
The search for effective protocols to reduce the incidence of root resorptions and allow periodontal ligament repair is still challenging, given the unpredictable outcome of late tooth replantation. The aim of this study was to assess the effects of both high-power diode laser irradiation (DL) and basic fibroblast growth factor (FGF) on the periodontal healing of replanted teeth after extended extra-oral dry time METHODS: Maxillary incisors of 50 male rats were extracted and assigned to three experimental and two control groups (n = 10)...
October 17, 2016: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/27672630/a-nano-indentation-identification-technique-for-viscoelastic-constitutive-characteristics-of%C3%A2-periodontal-ligaments
#4
H Ashrafi, M Shariyat
INTRODUCTION: Nano-indentation has recently been employed as a powerful tool for determining the mechanical properties of biological tissues on nano and micro scales. A majority of soft biological tissues such as ligaments and tendons exhibit viscoelastic or time-dependent behaviors. The constitutive characterization of soft tissues is among very important subjects in clinical medicine and especially, biomechanics fields. Periodontal ligament plays an important role in initiating tooth movement when loads are applied to teeth with orthodontic appliances...
June 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/27638921/periodontal-tissue-regeneration-using-syngeneic-adipose-derived-stromal-cells-in-a-mouse-model
#5
Mathieu Lemaitre, Paul Monsarrat, Vincent Blasco-Baque, Pascale Loubières, Rémy Burcelin, Louis Casteilla, Valérie Planat-Bénard, Philippe Kémoun
: : Current treatment of periodontitis is still associated with a high degree of variability in clinical outcomes. Recent advances in regenerative medicine by mesenchymal cells, including adipose stromal cells (ASC) have paved the way to improved periodontal regeneration (PD) but little is known about the biological processes involved. Here, we aimed to use syngeneic ASCs for periodontal regeneration in a new, relevant, bacteria-induced periodontitis model in mice. Periodontal defects were induced in female C57BL6/J mice by oral gavage with periodontal pathogens...
September 16, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27600358/the-differentiation-potential-of-gingival-mesenchymal-stem-cells-induced-by-apical-tooth-germ-cell%C3%A2-conditioned-medium
#6
Yan Chen, Hongwei Liu
Gingival-derived mesenchymal stem cells (GMSCs) have recently been harvested; however, the use of GMSCs in periodontal tissue engineering requires further study. The present study established an indirect co‑culture system between rat apical tooth germ‑conditioned medium (APTG‑CM) and GMSCs, in order to determine the effects on periodontal tissue differentiation in vitro and in vivo. Using the limiting dilution technique, single‑colony derived human GMSCs and periodontal ligament stem cells (PDLSCs) were isolated and expanded to obtain homogeneous populations...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27583044/collagen-hydrogel-scaffold-and-fibroblast-growth-factor-2-accelerate-periodontal-healing-of-class-ii-furcation-defects-in-dog
#7
Takehito Momose, Hirofumi Miyaji, Akihito Kato, Kosuke Ogawa, Takashi Yoshida, Erika Nishida, Syusuke Murakami, Yuta Kosen, Tsutomu Sugaya, Masamitsu Kawanami
OBJECTIVE: Collagen hydrogel scaffold exhibits bio-safe properties and facilitates periodontal wound healing. However, regenerated tissue volume is insufficient. Fibroblast growth factor-2 (FGF2) up-regulates cell behaviors and subsequent wound healing. We evaluated whether periodontal wound healing is promoted by application of collagen hydrogel scaffold in combination with FGF2 in furcation defects in beagle dogs. METHODS: Collagen hydrogel was fabricated from bovine type I collagen with an ascorbate-copper ion cross-linking system...
2016: Open Dentistry Journal
https://www.readbyqxmd.com/read/27407006/filamin-a-regulates-the-organization-and-remodeling-of-the-pericellular-collagen-matrix
#8
Masaru Mezawa, Vanessa I Pinto, Mwayi P Kazembe, Wilson S Lee, Christopher A McCulloch
Extracellular matrix remodeling by cell adhesion-related processes is critical for proliferation and tissue homeostasis, but how adhesions and the cytoskeleton interact to organize the pericellular matrix (PCM) is not understood. We examined the role of the actin-binding protein, filamin A (FLNa), in pericellular collagen remodeling. Compared with wild-type (WT), mice with fibroblast-specific deletion of FLNa exhibited higher density but reduced organization of collagen fibers after increased loading of the periodontal ligament for 2 wk...
October 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27280804/surface-chemistry-of-nanoscale-mineralized-collagen-regulates-periodontal-ligament-stem-cell-fate
#9
Yu Fu, Shuai Liu, Sheng-Jie Cui, Xiao-Xing Kou, Xue-Dong Wang, Xiao-Mo Liu, Yue Sun, Gao-Nan Wang, Yan Liu, Yan-Heng Zhou
The interplay between stem cells and their extracellular microenvironment is of critical importance to the stem cell-based therapeutics in regenerative medicine. Mineralized collagen is the main component of bone extracellular matrix, but the effect of interfacial properties of mineralized collagen on subsequent cellular behaviors is unclear. This study examined the role of surface chemistry of nanoscale mineralized collagen on human periodontal ligament stem cell (hPDLSC) fate decisions. The intrafibrillarly mineralized collagen (IMC), fabricated by a biomimetic bottom-up approach, showed a bonelike hierarchy with nanohydroxyapatites (HAs) periodically embedded within fibrils...
June 29, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27260210/removal-process-of-prion-and-parvovirus-from-human-platelet-lysates-used-as-clinical-grade-supplement-for-ex-vivo-cell-expansion
#10
Yu-Chun Kao, Andy Bailey, Bernhard Samminger, Junji Tanimoto, Thierry Burnouf
BACKGROUND AIMS: Pooled human platelet lysate (HPL) is becoming the new gold standard as supplement for ex vivo cell culture for clinical protocols. However, the risk of pathogen contamination of HPL increases with the platelet pool size. We hypothesized that hollow fiber anion exchange membrane chromatography using QyuSpeed D (QSD) could remove resistant and untested bloodborne pathogens, such as parvoviruses and prions, from HPL-supplemented growth media without substantially affecting their capacity to support ex vivo cell expansion...
July 2016: Cytotherapy
https://www.readbyqxmd.com/read/27153292/periodontal-wound-healing-by-transplantation-of-jaw-bone-marrow-derived-mesenchymal-stem-cells-in-chitosan-anorganic-bovine-bone-carrier-into-one-wall-infrabony-defects-in-beagles
#11
Shengqi Zang, Lei Jin, Shuai Kang, Xin Hu, Meng Wang, Jinjin Wang, Bo Chen, Bo Peng, Qintao Wang
BACKGROUND: This study aims to evaluate the performance of chitosan/anorganic bovine bone (C/ABB) scaffold seeded with human jaw bone marrow-derived mesenchymal stem cells (hJBMMSCs) in supporting the healing/repair of 1-wall critical-size periodontal defects. METHODS: Physical properties of the C/ABB scaffold were compared with those of the chitosan scaffold. hJBMMSCs were obtained from healthy human alveolar bone during the extraction of third molar impacted teeth...
August 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27129490/transcriptome-reveals-cathepsin-k-in-periodontal-ligament-differentiation
#12
S Yamada, N Ozaki, K Tsushima, S Yamaba, C Fujihara, T Awata, H Sakashita, T Kajikawa, J Kitagaki, M Yamashita, M Yanagita, S Murakami
Periodontal ligaments (PDLs) play an important role in remodeling the alveolar bond and cementum. Characterization of the periodontal tissue transcriptome remains incomplete, and an improved understanding of PDL features could aid in developing new regenerative therapies. Here, we aimed to generate and analyze a large human PDL transcriptome. We obtained PDLs from orthodontic treatment patients, isolated the RNA, and used a vector-capping method to make a complementary DNA library from >20,000 clones. Our results revealed that 58% of the sequences were full length...
August 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27076780/functional-role-of-hsp47-in-the-periodontal-ligament-subjected-to-occlusal-overload-in-mice
#13
Hiroaki Mimura, Tatsuo Takaya, Saeka Matsuda, Keisuke Nakano, Rina Muraoka, Mihoko Tomida, Norimasa Okafuji, Takeo Fujii, Toshiyuki Kawakami
We carried out an experiment to induce traumatic occlusion in mice periodontal tissue and analyzed the expression of HSP47. Continuous traumatic occlusion resulted to damage and remodeling of periodontal ligament as well as increase in osteoclasts and bone resorption. Four days after traumatic occlusion, osteoclasts did not increase but Howship's lacunae became enlarged. That is, the persistent occlusal overload can destroy collagen fibers in the periodontal ligament. This was evident by the increased in HSP47 expression with the occlusal overload...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27058388/stress-distribution-in-roots-restored-with-fiber-posts-and-an-experimental-dentin-post-3d-fea
#14
Hugo Henrique Diana, Juliana Santos Oliveira, Mariana Carolina de Lara Ferro, Yara T Corrêa Silva-Sousa, Érica Alves Gomes
The aim of this study was to compare the stress distribution in radicular dentin of a maxillary canine restored with either a glass fiber post, carbon fiber post or an experimental dentin post using finite element analysis (3D-FEA). Three 3D virtual models of a maxillary canine restored with a metal-ceramic crown and glass fiber post (GFP), carbon fiber post (CFP), and experimental dentin post (DP) were obtained based on micro-CT images. A total of 180 N was applied on the lingual surface of the incisal third of each tooth at 45 degrees...
March 2016: Brazilian Dental Journal
https://www.readbyqxmd.com/read/26987551/twenty%C3%A2-years-of-enamel-matrix-derivative-the-past-the-present-and-the-future
#15
Richard J Miron, Anton Sculean, David L Cochran, Stuart Froum, Giovanni Zucchelli, Carlos Nemcovsky, Nikos Donos, Staale Petter Lyngstadaas, James Deschner, Michel Dard, Andreas Stavropoulos, Yufeng Zhang, Leonardo Trombelli, Adrian Kasaj, Yoshinori Shirakata, Pierpaolo Cortellini, Maurizio Tonetti, Giulio Rasperini, Søren Jepsen, Dieter D Bosshardt
BACGROUND: On June 5th, 2015 at Europerio 8, a group of leading experts were gathered to discuss what has now been 20 years of documented evidence supporting the clinical use of enamel matrix derivative (EMD). Original experiments led by Lars Hammarström demonstrated that enamel matrix proteins could serve as key regenerative proteins capable of promoting periodontal regeneration including new cementum, with functionally oriented inserting new periodontal ligament fibres, and new alveolar bone formation...
August 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/26930474/hyperocclusion-stimulates-the-expression-of-collagen-type-xii-in-periodontal-ligament
#16
Takashi Tsuzuki, Hiroshi Kajiya, Kazuko T-Goto, Takashi Tsutsumi, Tetsuomi Nemoto, Koji Okabe, Yutaka Takahashi
OBJECTIVES: It is known that excessive mechanical force exerted by hyperocclusion induces occlusal trauma. However, the mechanism of the process remains unclear. In the present study, we employed an in vivo hyperocclusion rodent model to examine morphological and biological mechanisms of occlusal trauma in periodontal ligament tissue. DESIGN: To investigate alveolar bone resorption, tooth sections were stained to detect osteoclasts. To investigate the relationship between hyperocclusion and the regeneration of the cell matrix, we examined the effect of hyperocclusal force on the expression of collagens using immunohistochemistry and quantitative PCR methods...
June 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/26920510/dynamic-tensile-properties-of-bovine-periodontal-ligament-a-nonlinear-viscoelastic-model
#17
Iman Z Oskui, Ata Hashemi
As a support to the tooth, the mechanical response of the periodontal ligament (PDL) is complex. Like other connective tissues, the PDL exhibits non-linear and time-dependent behavior. The viscoelasticity of the PDL plays a significant role in low and high loading rates. Little information, however, is available on the short-term viscoelastic behavior of the PDL. Also, due to the highly non-linear stress-strain response, it was hypothesized that the dynamic viscoelastic properties of the PDL would be greatly dependent on the preload...
March 21, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/26917494/electrical-stimulation-enhances-tissue-reorganization-during-orthodontic-tooth-movement-in-rats
#18
Gisele Sampaio Spadari, Ewerton Zaniboni, Silvia Amelia Scudeler Vedovello, Mauro Pedrine Santamaria, Maria Esméria Corezola do Amaral, Gláucia Maria Tech Dos Santos, Marcelo Augusto Marretto Esquisatto, Fernanda Aparecida Sampaio Mendonca, Milton Santamaria-Jr
OBJECTIVE: This study evaluated the effects of a low-intensity electric current on tissue reorganization during experimental orthodontic tooth movement. MATERIALS AND METHODS: Thirty-two animals were divided into two groups evaluated on days 3 and 7: OTM-orthodontic tooth movement and OTM + MC-orthodontic tooth movement and microcurrent application (10 μA/5 min). The samples were processed for histological, morphometric, and Western blotting analysis. RESULTS: Analysis of the periodontal ligament (PL) showed a significantly smaller number of granulocytes in the OTM + MC group on day 7...
February 26, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/26893228/inclusion-of-the-periodontal-ligament-in-studies-on-the-biomechanical-behavior-of-fiber-post-retained-restorations-an-in-vitro-study-and-three-dimensional-finite-element-analysis
#19
Carmen González-Lluch, Pablo-Jesús Rodríguez-Cervantes, Leopoldo Forner, Amaya Barjau
Endodontically treated teeth are known to have reduced structural strength. Periodontal ligament may influence fracture resistance. The purpose of this study was to assess the influence of including the periodontal ligament in biomechanical studies about endodontically treated and restored teeth. Forty human maxillary central incisors were treated endodontically and randomly divided into four groups: non-crowned (with and without an artificial ligament) and crowned (with and without an artificial ligament) with glass-ceramic crowns...
March 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/26880630/pth-intermittent-administration-may-be-a-useful-therapeutic-agent-to-avoid-premature-eruption-of-the-tooth
#20
Daniel Fernando Pereira Vasconcelos, Any Carolina Cardoso Guimarães Vasconcelos
Parathyroid hormone (PTH) acts as a controller of bone remodeling and has influence on periodontal tissues. In addition to the well-established catabolic effects (activation of bone resorption) of PTH, it is recognized that the PTH intermittent administration has anabolic effects (promotion of bone formation). However, there is no information regarding the effects of the PTH intermittent administration on the eruption tooth rate. Studies have shown that tooth eruption depends on the presence of osteoclasts to create an eruption pathway through the alveolar bone...
March 2016: Medical Hypotheses
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