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periodontal ligament fibers

José Luis Suarez-Franco, Febe Carolina Vázquez-Vázquez, Amaury Pozos-Guillen, Juan José Montesinos, Octavio Alvarez-Fregoso, Marco Antonio Alvarez-Perez
This study evaluated the influence in the biocompatibility of human periodontal ligament (hPDL) mesenchymal stromal cell onto poly lactic-acid (PLA) films and PLA fiber membrane. Fiber scaffold was prepared via air jet spinning (AJS) from PLA solutions (6, 7, and 10%) and analyzed using SEM, AFM and FTIR. Biocompatibility was evaluated by adhesion, proliferation and cell-material interaction. PLA film exhibited a smooth and homogenously surface topography in comparison with random orientation of PLA fiber with roughness structure where diameter size depends on PLA solution...
March 17, 2018: Dental Materials Journal
F Tirone, S Salzano, A Piattelli, V Perrotti, G Iezzi
OBJECTIVES: The aim of this study was to investigate for the first time the histological response of periodontium to mineral trioxide aggregate (MTA) and Biodentine in human experimental models. MATERIALS AND METHODS: Six patients scheduled for implant full-arch rehabilitation via the all-on-4 technique were randomly assigned to one of the two test groups: either to MTA or Biodentine treatment. For each patient, 2 teeth scheduled for strategic extraction were randomly assigned either to the test or to the control treatment...
March 6, 2018: Australian Dental Journal
Shuangshuang Ren, Yingfang Yao, He Zhang, Ruirui Fan, Yijun Yu, Jie Yang, Rui Zhang, Chao Liu, Weibin Sun, Leiying Miao
The periodontal ligament (PDL) is a specific connective tissue composed of organized and aligned collagenous fibers that fix the tooth root in the alveolar bone. The alignment of PDL fibers and their function have been neglected in the past, as many studies investigated the regeneration of the periodontium, including alveolar bone and cementum regeneration. In this study, we fabricated biodegradable aligned fibers (ε-caprolactone/collagen) by near-field electrospinning (NFE) to control the arrangement of human periodontal ligament stem cells (hPDLSCs), aiming to guide the oriented regeneration of the periodontal ligament...
December 1, 2017: Journal of Biomedical Nanotechnology
Abdullah A Meshni, Mohammed M Al Moaleem, Khurshid A Mattoo, Esam Halboub, Saleh Mh Alharisi, Ali E Shatifi, Saeed A Al Amriee, Nabiel Al Ghazali
AIM: Post and core procedures are important clinical methods in routine dental practice. The present research aimed to radiographically assess the quality of post seating performed by undergraduate students at the College of Dentistry, Jazan University. MATERIALS AND METHODS: A total of 343 periapical X-rays of cemented posts (170 from males and 173 from females) were assessed. The assessment covered tooth type, arch, gender, type of post, length of post in relation to the crown and root lengths, the presence of any abnormality in post space, status of the remaining gutta-percha (GP), and the presence or absence of spaces between the end of post and GP...
January 1, 2018: Journal of Contemporary Dental Practice
Izabela C M Moris, Carolina Alves Moscardini, Luana Kelle Batista Moura, Yara Teresinha Corrêa Silva-Sousa, Erica Alves Gomes
This study evaluated the stress distribution in endodontically treated teeth, weakened (W) or not weakened (NW), restored with different materials of prosthetic crown using 3D-FEA. Models of a maxillary canine were constructed based on micro-CT images and divided into the groups: G1 (control) - sound tooth; G2 to G7 - endodontically treated teeth restored with glass fiber post (GFP); which G2 to G4 simulated NW root and G5 to G7 simulated W root. For crown material the teeth were restored with: G2 and G5: metallic coping and ceramic veneering, G3 and G6: zirconia coping and ceramic veneering, G4 and G7: alumina coping and ceramic veneering...
November 2017: Brazilian Dental Journal
Pietro Ausiello, Stefano Ciaramella, Massimo Martorelli, Antonio Lanzotti, Fernando Zarone, David C Watts, Antonio Gloria
OBJECTIVE: To assess the effect of a ferrule design with specific post material-shape combinations on the mechanical behavior of post-restored canine teeth. METHODS: Micro-CT scan images of an intact canine were used to create a 3-D tessellated CAD model, from which the shapes of dentin, pulp and enamel were obtained and geometric models of post-endodontically restored teeth were created. Two types of 15mm post were evaluated: a quartz fiber post with conical-tapered shape, and a carbon (C) fiber post with conical-cylindrical shape...
December 2017: Dental Materials: Official Publication of the Academy of Dental Materials
Kazuya Matsuse, Yoshiya Hashimoto, Sachiro Kakinoki, Tetsuji Yamaoka, Shosuke Morita
We evaluated the effect of porous alpha-tricalcium phosphate (α-TCP) with immobilized basic fibroblast growth factor (bFGF) on periodontal regeneration in a canine model of 2-wall periodontal defects. Identical bone defects were made in the canine mandible; six defects in each animal were filled with porous α-TCP with bFGF bound via heparin (bFGF group), and the remaining defects were filled with unmodified porous α-TCP (control group). Micro-computed tomography and histological evaluation were performed at 2, 4, and 8 weeks post-implantation...
October 27, 2017: Medical Molecular Morphology
E M Varoni, S Vijayakumar, E Canciani, A Cochis, L De Nardo, G Lodi, L Rimondini, M Cerruti
Periodontal regeneration is still a challenge for periodontists and tissue engineers, as it requires the simultaneous restoration of different tissues-namely, cementum, gingiva, bone, and periodontal ligament (PDL). Here, we synthetized a chitosan (CH)-based trilayer porous scaffold to achieve periodontal regeneration driven by multitissue simultaneous healing. We produced 2 porous compartments for bone and gingiva regeneration by cross-linking with genipin either medium molecular weight (MMW) or low molecular weight (LMW) CH and freeze-drying the resulting scaffolds...
October 1, 2017: Journal of Dental Research
N F Omar, J R Gomes, J S Neves, P D Novaes
BACKGROUND AND OBJECTIVE: This study investigated the effect of occlusal contact loss (induced by tooth shortening), on matrix metalloproteinase (MMP)-2, membrane type 1-MMP (MT1-MMP) and tissue inhibitor of the MMP-2 (TIMP-2) expressions in the periodontal ligament of the rat incisor, as well as eruption rate, resistance and collagen organization. MATERIAL AND METHODS: Male Wistar rats were distributed into a control group, denominated normofunctional group, whose lower teeth underwent a normal eruption process; and a hypofunctional group, whose lower left incisor teeth were shortened every 2 days during 14 days...
October 17, 2017: Journal of Periodontal Research
Fanqiao Yang, Yingling Miao, Yan Wang, Li-Ming Zhang, Xuefeng Lin
Periodontitis is a widespread dental disease affecting 10 to 15% of worldwide adult population, yet the current treatments are far from satisfactory. The human periodontal ligament stem cell is a promising potential seed cell population type in cell-based therapy and tissue regeneration, which require appropriate scaffold to provide a mimic extracellular matrix. Zein, a native protein derived from corn, has an excellent biodegradability, and therefore becomes a hotspot on research and application in the field of biomaterials...
October 12, 2017: Materials
Ana Paula Simões Corrêa, Pedro Henrique Silva Gomes Ferreira, Sônia Regina Panzarini, Celso Koogi Sonoda, Eliana Aparecida Caliente, Wilson Roberto Poi
BACKGROUND/AIM: In cases of tooth avulsion, a minimal extra-alveolar dry storage period or the use of a suitable storage medium is crucial to maintaining the vitality of the periodontal ligament. Whey has similar properties to milk and has therefore been investigated as a storage medium for avulsed teeth. The aim of the present study was to evaluate the repair process after replantation of rat teeth kept in whey and whole milk. MATERIAL AND METHODS: Thirty-six male rats were divided into four groups of nine animals...
October 4, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Xuejing Duan, Mei Ji, Fengying Deng, Zhe Sun, Zhiyong Lin
OBJECTIVE: The aim of this study was to evaluate the effects of different concentrations of connective tissue growth factor (CTGF) on human periodontal ligament fibroblasts(HPLFs). DESIGN: HPLFs were cultured and identified. Then, different concentrations of CTGF (1, 5, 10, 50, 100ng/ml) were added to the HPLF culture. Next, CCK-8 assays, alkaline phosphatase (ALP) assays, hydroxyproline determination, alizarin red staining methods, Transwell chambers and real-time PCR methods were applied to observe the effects of CTGF on the proliferation, ALP activity, synthesis of collagen, formation of mineralized nodules and migration...
September 18, 2017: Archives of Oral Biology
H-C Lim, B-Y Cha, S U Song, J-H Yun
OBJECTIVE: to investigate whether harmine has a promotive effect on human periodontal ligament cells (hPDLCs)-induced tissue regeneration. MATERIALS AND METHODS: Various concentrations of harmine on hPDLCs proliferation were tested. Osteogenic and cementogenic characteristics were examined in hPDLC/rhBMP-2 and hPDLC/harmine by alizarin red S staining, real-time PCR, and Western blotting assay. The activity of harmine was investigated in an ectopic transplantation nude mouse model...
September 10, 2017: Oral Diseases
Juan Du, Minqi Li
The goal of periodontal regenerative therapy is to predictably restore the tooth's supporting periodontal tissues and form a new connective tissue attachment of periodontal ligament (PDL) fibers and new alveolar bone. Periostin is a matricellular protein so named for its expression primarily in the periosteum and PDL of adult mice. Its biological functions have been widely studied in areas such as cardiovascular physiology and oncology. Despite being initially identified in the dental tissues and bone, investigations of Periostin functions in PDL and alveolar-bone-related physiopathology are less abundant...
December 2017: Cellular and Molecular Life Sciences: CMLS
Chan Ho Park, Joung-Hwan Oh, Hong-Moon Jung, Yoonnyoung Choi, Saeed Ur Rahman, Sungtae Kim, Tae-Il Kim, Hong-In Shin, Yun-Sil Lee, Frank H Yu, Jeong-Hwa Baek, Hyun-Mo Ryoo, Kyung Mi Woo
Cementum formation on the exposed tooth-root surface is a critical process in periodontal regeneration. Although various therapeutic approaches have been developed, regeneration of integrated and functional periodontal complexes is still wanting. Here, we found that the OCCM30 cementoblasts cultured on fibrin matrix express substantial levels of matrix proteinases, leading to the degradation of fibrin and the apoptosis of OCCM30 cells, which was reversed upon treatment with a proteinase inhibitor, ε-aminocaproic acid (ACA)...
July 29, 2017: Acta Biomaterialia
Jung-Hoon Kim, Ki-Tae Koo, Joseph Capetillo, Jung-Ju Kim, Jung-Min Yoo, Heithem Ben Amara, Jung-Chul Park, Frank Schwarz, Ulf M E Wikesjö
PURPOSE: The aim of the present exploratory study was to evaluate extraction socket healing at sites with a history of periodontal and endodontic pathology. METHODS: The mandibular 4th premolar teeth in 5 adult beagle dogs served as experimental units. Periodontal and endodontic lesions were induced in 1 premolar site in each animal using wire ligatures and pulpal exposure over 3 months (diseased sites). The contralateral premolar sites served as healthy controls...
June 2017: Journal of Periodontal & Implant Science
Mari Kaneko, Eri Horinuki, Noriyoshi Shimizu, Masayuki Kobayashi
The periodontal ligament (PDL) includes several types of nerve endings, such as Aβ-, Aδ-, and C-fibers, which play critical roles in detecting the strength and direction of occlusal force. Previous studies have demonstrated that electrical stimulation of the PDL activates the somatosensory and insular cortices. However, the profile of cortical excitation in response to mechanical PDL stimulation mostly remains unknown. To investigate the differences in cortical responses to electrical and mechanical stimulation of the maxillary first molar, we performed optical imaging to determine the responding cortical regions in combination with a pharmacological approach...
June 30, 2017: Neuroscience
Andrea Schubert, Boris Schminke, Nicolai Miosge
Periodontitis refers to inflammatory disease of the periodontal structures (the gingiva, dental cementum, periodontal ligament (PDL) and alveolar bone) that ultimately leads to their destruction. Whereas collagens are well-examined main components of the periodontium, little is known about the other structural proteins that make up this tissue. The aim of this study was to identify new extracellular matrix (ECM) components, including fibulins and matrilins, in the periodontium of mice. After sacrificing 14 mice (Sv/129 strain), jaws were prepared...
October 2017: Archives of Oral Biology
Min-Woo Kim, Jung Tae Park, Jung Ho Kim, Seong-Joon Koh, Hyun-Sun Yoon, Soyun Cho, Hyun-Sun Park
BACKGROUND: Periostin is a novel matricellular protein expressed in many tissues, including bone, periodontal ligament, and skin. Although its expression is prominent in various fibrotic conditions, studies of periostin in localized scleroderma are rare. OBJECTIVE: To investigate the expression of periostin and other molecules in localized scleroderma. METHODS: A retrospective study of 14 patients with confirmed mature stage localized scleroderma was undertaken...
June 2017: Annals of Dermatology
X Pei, L Wang, C Chen, X Yuan, Q Wan, J A Helms
Our objective was to clarify the fate of the periodontal ligament (PDL) retained in the socket after tooth extraction, then determine if this tissue contributed to the osseointegration of "immediate" implants placed in these fresh extraction sockets. Mice underwent maxillary first molar extraction, the residual PDL was removed by an osteotomy, and titanium implants were placed. The osteotomy was created in such a way that the palatal surface was devoid of PDL remnants while the buccal, mesial, and distal surfaces retained PDL fibers...
July 2017: Journal of Dental Research
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