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Papillary VT

Riccardo Proietti, Santiago Rivera, Charles Dussault, Vidal Essebag, Martin L Bernier, Felix Ayala-Paredes, Mariano Badra-Verdu, Jean-François Roux
AIMS: Ventricular arrhythmias (VA) originating from a papillary muscle (PM) have recently been described as a distinct clinical entity with peculiar features that make its treatment with catheter ablation challenging. Here, we report our experience using an intracardiac echo-facilitated 3D electroanatomical mapping approach in a case series of patients undergoing ablation for PM VA. METHODS AND RESULTS: Sixteen patients who underwent catheter ablation for ventricular tachycardia (VT) or symptomatic premature ventricular contractions originating from left ventricular PMs were included in the study...
August 2, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Yasunori Kushiyama, Haruo Honjo, Ryoko Niwa, Hiroki Takanari, Masatoshi Yamazaki, Yoshio Takemoto, Ichiro Sakuma, Itsuo Kodama, Kaichiro Kamiya
It has been reported that blockade of the inward rectifier K(+) current (IK1) facilitates termination of ventricular fibrillation. We hypothesized that partial IK1 blockade destabilizes spiral wave (SW) re-entry, leading to its termination. Optical action potential (AP) signals were recorded from left ventricles of Langendorff-perfused rabbit hearts with endocardial cryoablation. The dynamics of SW re-entry were analyzed during ventricular tachycardia (VT), induced by cross-field stimulation. Intercellular electrical coupling in the myocardial tissue was evaluated by the space constant...
September 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
John P Hanley, Erin Jackson, Leslie A Morrissey, Donna M Rizzo, Brian L Sprague, Indra Neil Sarkar, Frances E Carr
BACKGROUND: The increasing incidence of thyroid cancer has resulted in the rate tripling over the past 30 years. Reasons for this increase have not been established. Geostatistics and geographic information system (GIS) tools have emerged as powerful geospatial technologies to identify disease clusters, map patterns and trends, and assess the impact of ecological and socioeconomic factors (SES) on the spatial distribution of diseases. In this study, these tools were used to analyze thyroid cancer incidence in a rural population...
July 2015: Thyroid: Official Journal of the American Thyroid Association
Francesco Santoro, Luigi DI Biase, Patrick Hranitzky, Javier E Sanchez, Pasquale Santangeli, Alessandro Paoletti Perini, John David Burkhardt, Andrea Natale
INTRODUCTION: Premature ventricular complexes (PVCs) and ventricular tachycardia (VT) arising from papillary muscles of both ventricles have recently been described. There is a lack of data on VT originating from the right ventricular papillary (RV PAP) muscles. There have been no prior studies focused on the electrocardiogram (ECG) features and ablation of PVC/VT arising from the septal papillary muscle of the right ventricle. METHODS: Among 155 consecutive patients with normal structural heart who underwent catheter ablation of PVC/VT, 8 patients with PVC/VT from the septal RV PAP muscle were identified...
February 2015: Journal of Cardiovascular Electrophysiology
Xiao-Jing Zhang, Jun Qiu, Gao Li
To study the antiarrhythmic effect of the newly developed alpha/beta-blocker TJ0711, a variety of animal models of arrhythmia were induced by CaCl2, ouabain and ischemia/reperfusion. Glass microelectrode technique was used to observe action potentials of right ventricular papillary muscle of guinea pig. The onset time of arrhythmia induced by CaCl2 was significantly prolonged by TJ0711 at 0.75, 1.5 and 3 mg x kg(-1) doses. TJ0711 (1.5 and 3 mg x kg(-1)) can significantly shorten the ventricular tachycardia (VT) and ventricular fibrillation (VF) duration, the incidence of VF and mortality were significantly reduced...
March 2014: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
Dong-Lu Bai, Wei-Zhou Chen, Yun-Xin Bo, Yue-Li Dong, Ai-Li Kang, Wei-Kang Sun, Wei Wang, Zhong-Liang Hu, Yi-Ping Wang
AIM: To investigate the anti-arrhythmic effects of sulfamide analogues of changrolin and to characterize the sulfate of compound 6f (sulcardine sulfate, Sul) as a novel anti-arrhythmic agent. METHODS: The anti-arrhythmic effects of compounds were studied against aconitine-induced arrhythmias in rats and ouabain-induced arrhythmias in guinea pigs. The effects of Sul on transmembrane action potentials were investigated in isolated rabbit sinoatrial nodes and guinea-pig papillary muscles using intracellular recording...
September 2012: Acta Pharmacologica Sinica
Shiro Nakahara, Noritaka Toratani, Kan Takayanagi
A 62-year-old man without structural heart disease underwent electrophysiological testing for ventricular tachycardia (VT). Hemodynamically unstable VT was induced after isoproterenol (ISP) provocation. Electroanatomical mapping using a multipolar catheter identified the earliest activation originating from the posterior papillary muscle (PPM) where prepotentials preceding the local ventricular electrogram were observed. Irrigated radiofrequency current guided by the shadow of a multipolar catheter eliminated the VT...
July 2012: Indian Pacing and Electrophysiology Journal
Junbeom Park, Young-Hoon Kim, Chun Hwang, Hui-Nam Pak
PURPOSE: We hypothesized that Purkinje potential and their preferential conduction to the left ventricle (LV) posteroseptum during sinus rhythm (SR) are part of reentrant circuits of idiopathic left ventricular tachycardia (ILVT) and reentry anchors to papillary muscle. MATERIALS AND METHODS: In 14 patients with ILVT (11 men, mean age 31.5±11.1 years), we compared Purkinje potential and preferential conduction during SR with VT by non-contact mapping (NCM). If clear Purkinje potential(SR) was observed in the LV posteroseptum and the earliest activation site (EA) of preferential conduction at SR (EA(SR)) was well matched with that of VT (EA(VT)), EA(SR) was targeted for radiofrequency catheter ablation (RFCA)...
March 2012: Yonsei Medical Journal
Agata Bałdys-Waligórska, Filip Gołkowski, Anna Krzentowska-Korek, Alicja Hubalewska-Dydejczyk
INTRODUCTION: A group of differentiated thyroid carcinoma (DTC) patients receiving post thyroidectomy rhTSH-aided radioiodine treatment (group I) was compared with patients treated with ¹³¹I following endogenous stimulation of TSH (group II) after L-thyroxine withdrawal. MATERIAL AND METHODS: Group I consisted of 66 patients of mean age 51.7 ± 16.2 years (58 females and 8 males). Group II included 76 patients of mean age 54.8 ± 14.7 years (67 females and 9 males)...
September 2010: Endokrynologia Polska
Xingyu Wang, Zhixiong Zhang, Aihua Liu
OBJECTIVE: The action and mechanism of ginkgo leaf extract (EGB50) in fighting arrhythmia were studies. METHOD: The animal model of arrhythmia was established by intravenous drip of aconitine and ouabain, and the standard microelectrode technique was used. RESULT: In Oua model, threshold doses of ouabain induced VP, VT, VF, CA were observed. GBE50 significantly increased threshold doses of ouabain. In Aco model, threshold doses of Aco induced VP, VT, VF, CA were observed, GBE50 significantly increased threshold doses of Aco...
January 2010: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Thomas Crawford, Giesela Mueller, Eric Good, Krit Jongnarangsin, Aman Chugh, Frank Pelosi, Matthew Ebinger, Hakan Oral, Fred Morady, Frank Bogun
BACKGROUND: Premature ventricular complexes (PVCs) and ventricular tachycardia (VT) with origin in the left ventricular papillary muscle have recently been described. There are no prior studies describing the characteristics of the ventricular arrhythmias (VAs) arising from the right ventricular papillary muscles (RV PAPs). METHODS: Among 169 consecutive patients who underwent a catheter ablation of a VA, eight patients with RV PAPs were identified (seven men, mean PVC burden 17...
June 2010: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Omar Abouezzeddine, Mahmoud Suleiman, Traci Buescher, Suraj Kapa, Paul A Friedman, Arshad Jahangir, Jennifer A Mears, Dorothy J Ladewig, Thomas M Munger, Stephen C Hammill, Douglas L Packer, Samuel J Asirvatham
BACKGROUND: Radiofrequency (RF) ablation for ventricular tachycardia (VT) has high failure rates. Whether endocavitary structures (ECS) such as the papillary muscles (PMs), moderator bands (MBs), or false tendons (FTs) impact VT ablation is unknown. METHODS AND RESULTS: We retrospectively reviewed records of 190 consecutive patients presenting for VT ablation and identified 46 (24%) where ECS affected ablation. In 31 of 46 patients (67%), the ECS created difficulty with catheter manipulation (n = 20), interpretation of pace map data (n = 7), or with accurately defining a scar (n = 4)...
March 2010: Journal of Cardiovascular Electrophysiology
Harish Doppalapudi, Takumi Yamada, H Thomas McElderry, Vance J Plumb, Andrew E Epstein, G Neal Kay
BACKGROUND: Several distinct forms of focal ventricular tachycardia (VT) from the left ventricle (LV) have been described. We report a new syndrome of VT arising from the base of the posterior papillary muscle in the LV. METHODS AND RESULTS: Among 290 consecutive patients who underwent ablation for VT or symptomatic premature ventricular complexes (PVCs) based on a focal mechanism, 7 patients were found to have an ablation site at the base of the posterior papillary muscle in the LV...
April 2008: Circulation. Arrhythmia and Electrophysiology
Takumi Yamada, H Thomas McElderry, Harish Doppalapudi, G Neal Kay
A 57-year-old man with idiopathic ventricular tachycardia (VT) underwent electrophysiological testing. Activation mapping revealed two remote earliest ventricular activation sites on anterior and posterior sides of the anterior papillary muscle. On the anterior side, far-field activity preceded near-field activity. Catheter ablation was successful on the posterior side. Ventricular far-field activity may provide diagnostic challenges in identifying papillary muscle VT origins.
October 2009: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Wei ZHANG, Zhi-guo YE, Jie CUI, Shui-feng QIU, Wan-hong XU, Hui-ping WANG, Lin-bo QIAN, Hui-di JIANG, Qiang XIA
OBJECTIVE: To investigate the effect of ethyl acetate extract from Chrysanthemum Morifolium Ramat (CME) on experimental arrhythmia induced by ischemia/reperfusion or aconitine in rats and to explore its underlying mechanisms. METHODS: Arrhythmia model in intact rat was induced by aconitine (30 microg/kg body weight, i.v.). In isolated Langendorff perfused rat hearts, regional ischemia and reperfusion was induced by ligation and release of left anterior descending artery...
July 2009: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
Takumi Yamada, H Thomas McElderry, Taro Okada, Yoshimasa Murakami, Harish Doppalapudi, Naoki Yoshida, James D Allred, Toyoaki Murohara, G Neal Kay
INTRODUCTION: Focal ventricular arrhythmias (VAs) have been reported to arise from the posterior papillary muscle in the left ventricle (LV). We report a distinct subgroup of idiopathic VAs arising from the anterior papillary muscle (APM) in the LV. METHODS AND RESULTS: We studied 432 consecutive patients undergoing catheter ablation for VAs based on a focal mechanism. Six patients were identified with ventricular tachycardia (VT, n = 1) or premature ventricular contractions (PVCs, n = 5) with the earliest site of ventricular activation localized to the base (n = 3) or middle portion (n = 3) of the LV APM...
August 2009: Journal of Cardiovascular Electrophysiology
Eduardo Back Sternick, Frederico Correa, Ricardo Negri, Ricardo Baeta Scarpelli, Luiz Márcio Gerken
BACKGROUND: A new distinct clinical syndrome comprising of ventricular tachycardia or frequent premature beats arising from the base of the posterior papillary muscle has recently been reported. The cardiac arrhythmia had a non-reentrant mechanism and none of the patients had left ventricular dysfunction. CASE REPORT: We report on a 55-year-old female patient presenting with a dilated cardiomyopathy and frequent ventricular premature beats (VPB). Ventricular arrhythmia was refractory to amiodarone...
June 2009: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Takumi Yamada, Paul B Tabereaux, Harish Doppalapudi, H Thomas McElderry, G Neal Kay
A 61-year-old man with a remote posterior myocardial infarction underwent electrophysiological testing for a ventricular tachycardia (VT) storm. Repeated cardioversions terminated the VT with immediate resumption after one sinus beat. Pacing neither terminated the VT nor demonstrated transient entrainment. Echocardiographically guided electroanatomic mapping revealed a centrifugal activation from the septal mid-apical region of the left ventricle on the septal portion of the posterior papillary muscle where a high frequency potential was observed within the local ventricular electrogram...
March 2009: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Eric Good, Benoit Desjardins, Krit Jongnarangsin, Hakan Oral, Aman Chugh, Matthew Ebinger, Frank Pelosi, Fred Morady, Frank Bogun
BACKGROUND: The papillary muscles (PAP) have been implicated in arrhythmogenesis, largely based on theoretical considerations and experimental studies. Few clinical studies have described papillary muscle arrhythmias. OBJECTIVE: This study sought to describe ventricular arrhythmias arising from the left ventricular PAPs in a consecutive series of patients without prior myocardial infarction and to compare these arrhythmias with fascicular arrhythmias. METHODS: Nine of 122 consecutive patients (7%) presenting with symptomatic premature ventricular complexes (PVCs) or nonsustained ventricular tachycardia (VT) were found to have a site of origin in the anterolateral or posteromedial left ventricular PAP...
November 2008: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Michael Aref, Amir R Chaudhari, Keith L Bailey, Susanne Aref, Erik C Wiener
PURPOSE: The purpose of this study was to compare histologically determined cellularity and extracellular space to dynamic contrast-enhanced magnetic resonance imaging (DCE MRI)-based maps of a two-compartment model's parameters describing tumor contrast agent extravasation, specifically tumor extravascular extracellular space (EES) volume fraction (ve), tumor plasma volume fraction (vp) and volume-normalized contrast agent transfer rate between tumor plasma and interstitium (KTRANS/VT)...
November 2008: Magnetic Resonance Imaging
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