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https://www.readbyqxmd.com/read/28844127/direct-conversion-of-human-umbilical-cord-blood-into-induced-neural-stem-cells-with-sox2-and-hmga2
#1
Jae-Jun Kim, Ji-Hee Shin, Kyung-Rok Yu, Byung-Chul Lee, Insung Kang, Jin Young Lee, Da-Hyun Kim, Yoojin Seo, Hyung-Sik Kim, Soon Won Choi, Kyung-Sun Kang
Recent advances have shown the direct reprogramming of mouse and human fibroblasts into induced neural stem cells (iNSCs) without passing through an intermediate pluripotent state. Thus, direct reprogramming strategy possibly provides a safe and homogeneous cellular platform. However, the applications of iNSCs for regenerative medicine are limited by the restricted availability of cell sources. Human umbilical cord blood (hUCB) cells hold great potential in that immunotyped hUCB units can be immediately obtained from public banks...
August 31, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28836380/comparison-of-human-umbilical-cord-blood-processing-with-or-without-hydroxyethyl-starch
#2
Milad Souri, Mahin Nikougoftar Zarif, Mahboobeh Rasouli, Khadijeh Golzadeh, Mozhdeh Nakhlestani Hagh, Nasim Ezzati, Kamran Atarodi
BACKGROUND: Umbilical cord blood (UCB) processing with hydroxyethyl starch (HES) is the most common protocol in the cord blood banks. The quality of UCB volume reduction was guaranteed by minimum manipulation of cord blood samples in the closed system. This study aimed to analyze and compare cell recovery and viability of UCB processed using the Sepax automated system in the presence and absence of HES. STUDY DESIGN AND METHODS: Thirty UCB bags with a total nucleated cell (TNC) count of more than 2...
August 23, 2017: Transfusion
https://www.readbyqxmd.com/read/28823040/maternal-predictors-and-quality-of-umbilical-cord-blood-units
#3
Beata Bielec-Berek, Żaneta Jastrzębska-Stojko, Agnieszka Drosdzol-Cop, Cecylia Jendyk, Dariusz Boruczkowski, Tomasz Ołdak, Agnieszka Nowak-Brzezińska, Rafał Stojko
The aim of the study was to determine the relationship between the maternal age at delivery and selected properties of the cord blood stem cells. The study included 50 pregnant women aged between 18 and 38 years in which spontaneous labors or elective cesarean sections were performed. Umbilical cord blood was collected immediately after the women were delivered of newborns. The samples were analyzed in the Polish Stem Cells Bank in Warsaw. The highest mean WBC level (p < 0.05) was observed in the umbilical blood collected from patients aged 35 years and more...
August 19, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28758211/cytomegalovirus-viral-load-in-cord-blood-and-impact-of-congenital-infection-on-markers-of-hematopoietic-progenitor-cell-potency
#4
M Susana Albano, Rodica Ciubotariu, Ludy Dobrila, Michal Tarnawski, Margely DeLeon, Chiseko Watanabe, Siddarth Krishnan, Andromachi Scaradavou, Pablo Rubinstein
BACKGROUND: The low incidence of cytomegalovirus (CMV) infection in neonates decreases the risk of viral transmission with cord blood transplantation. Cord blood donors are screened by testing the maternal sample for total antibodies to CMV. Some cord blood banks also screen cord blood for CMV-DNA. The aim of this study was to develop and validate a multiplex real-time polymerase chain reaction assay to measure CMV viral load in cord blood from asymptomatic infants with congenital CMV infection and to assess the impact of CMV infection on cord blood hematopoietic progenitor cell concentrations and colony-forming unit functionality...
July 31, 2017: Transfusion
https://www.readbyqxmd.com/read/28751465/india-cracks-down-on-clinics-offering-stem-cell-therapy-and-blood-cord-banking
#5
Sumi S Dutta
No abstract text is available yet for this article.
July 27, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28731615/the-prevalence-of-ccr5-%C3%AE-32-mutation-in-a-cohort-of-saudi-stem-cell-donors
#6
M Alarifi, F Al-Amro, A Alalwan, A Al-Turki, H Fakhoury, N Atallah, M Al Muallimi, M Al-Balwi, M ALzahrani, A Alaskar, A Hajeer, D Jawdat
CCR5 is a chemokine receptor that also was found to be used by HIV as a co-receptor for entering target cells. A 32 bp deletion was described in certain people that rendered CCR5 non-functional. The mutant allele CCR5-Δ32 has been shown to prevent HIV infection. In addition, stem cell transplantation with the CCR5-Δ32 homozygous genotype can lead to clearance of HIV infection. In this study, our aim was to investigate the frequency of CCR5-Δ32 mutation in a cohort of stem cell donors from cord blood bank and stem cell donor registry...
July 21, 2017: HLA
https://www.readbyqxmd.com/read/28716596/quality-comparison-of-umbilical-cord-blood-cryopreserved-with-conventional-versus-automated-systems
#7
Kyeong Mi Kim, Ji Young Huh, Jin Ju Kim, Myung Seo Kang
Umbilical cord blood (CB) banks usually freeze and store CB for clinical transplantation using conventional controlled-rate freezer or the automated BioArchive system. The aim of this study is to compare the quality of CB cryopreserved with conventional and automated methods and to make clear the cause of the quality difference between the two methods. The experiment used 80 CB units: 40 were conventionally cryopreserved and the remainder were cryopreserved with a BioArchive. After thawing, the following measures of CB quality were compared: recovery rates of cell count, cell viability of total nucleated cells (TNCs), mononuclear cells (MNCs), and CD34+ cells, as well as colony-forming unit-granulocyte/macrophage (CFU-GM) content...
July 14, 2017: Cryobiology
https://www.readbyqxmd.com/read/28711452/hematopoietic-stem-cell-transplantation-in-algeria
#8
REVIEW
Mohamed Amine Bekadja, Mohamed Brahimi, Soufi Osmani, Nabil Yafour, Amina Krim, Faiza Serradj, Souad Talhi, Kamila Amani, Rachid Amar Bouhass
INTRODUCTION: Algeria is a country of 40,.4 million inhabitants and half of which is under 30years. In Algeria, Health-care insurance covered, 90% of the population. Health care is free and it is supported by the Ministry of Health. 16 university hospitals exist in Algeria and only two (Algiers and Oran) practicing bone marrow transplant. Adult hematologic malignancies account for 10% (about 4000 new cases/year) of the malignancy affecting in most cases young patients under 65years of age...
July 11, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28687394/umbilical-cord-blood-cytomegalovirus-serostatus-does-not-have-an-impact-on-outcomes-of-umbilical-cord-blood-transplantation-for-acute-leukemia
#9
Olga Nikolajeva, Vanderson Rocha, Robert Danby, Annalisa Ruggeri, Fernanda Volt, Etienne Baudoux, Susana G Gomez, Gezine Kögler, Jerome Larghero, Lucilla Lecchi, Mar Sanchez Martinez, Cristina Navarrete, Fabienne Pouthiers, Sergio Querol, Chantal Kenzey, Richard Szydlo, Eliane Gluckman, Alejandro Madrigal
Several studies have reported an impact of adult hematopoietic stem cell donor cytomegalovirus (CMV) serostatus on allogeneic hematopoietic cell transplantation outcomes. Limited data, however, are available on the impact of cord blood unit (CBU) CMV serostatus on allogeneic umbilical cord blood transplantation (UCBT) outcomes. We analyzed, retrospectively, the impact of CBU CMV serostatus on relapse incidence (RI) and 2-year nonrelapse mortality (NRM) of single-unit CBU transplantation for acute leukemia. Data from 1177 de novo acute leukemia pediatric and adult patients transplanted within European Group for Blood and Marrow Transplantation centers between 2000 and 2012 were analyzed...
July 4, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28680446/donor-selection-for-allogenic-hemopoietic-stem-cell-transplantation-clinical-and-ethical-considerations
#10
REVIEW
Irene Riezzo, Natascha Pascale, Raffaele La Russa, Arcangelo Liso, Monica Salerno, Emanuela Turillazzi
Allogenic hematopoietic progenitor cell transplantation (allo-HSCT) is an established treatment for many diseases. Stem cells may be obtained from different sources: mobilized peripheral blood stem cells, bone marrow, and umbilical cord blood. The progress in transplantation procedures, the establishment of experienced transplant centres, and the creation of unrelated adult donor registries and cord blood banks gave those without an human leucocyte antigen- (HLA-) identical sibling donor the opportunity to find a donor and cord blood units worldwide...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28653354/a-new-strategy-for-umbilical-cord-blood-collection-developed-at-the-first-colombian-public-cord-blood-bank-increases-total-nucleated-cell-content
#11
Diana Vanegas, Lady Triviño, Cristian Galindo, Leidy Franco, Gustavo Salguero, Bernardo Camacho, Ana-María Perdomo-Arciniegas
BACKGROUND: The total nucleated cell dosage of umbilical cord blood (UCB) is an important factor in determining successful allogeneic hematopoietic stem cell transplantation after a minimum human leukocyte antigen donor-recipient match. The northern South American population is in need of a new-generation cord blood bank that cryopreserves only units with high total nucleated cell content, thereby increasing the likelihood of use. Colombia set up a public cord blood bank in 2014; and, as a result of its research for improving high total nucleated cell content, a new strategy for UCB collection was developed...
June 26, 2017: Transfusion
https://www.readbyqxmd.com/read/28492861/vena-cava-filter-use-in-trauma-and-rates-of-pulmonary-embolism-2003-2015
#12
MULTICENTER STUDY
Alan D Cook, Brian W Gross, Turner M Osler, Katelyn J Rittenhouse, Eric H Bradburn, Steven R Shackford, Frederick B Rogers
Importance: Vena cava filter (VCF) placement for pulmonary embolism (PE) prophylaxis in trauma is controversial. Limited research exists detailing trends in VCF use and occurrence of PE over time. Objective: To analyze state and nationwide temporal trends in VCF placement and PE occurrence from 2003 to 2015 using available data sets. Design, Setting, and Participants: A retrospective trauma cohort study was conducted using data from the Pennsylvania Trauma Outcome Study (PTOS) (461 974 patients from 2003 to 2015), the National Trauma Data Bank (NTDB) (5 755 095 patients from 2003 to 2014), and the National (Nationwide) Inpatient Sample (NIS) (24 449 476 patients from 2003 to 2013) databases...
August 1, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28488970/is-it-time-to-re-think-a-sustainable-banking-model-for-the-italian-cord-blood-network
#13
EDITORIAL
Nicoletta Sacchi
No abstract text is available yet for this article.
April 13, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488969/a-cost-analysis-of-public-cord-blood-banks-belonging-to-the-italian-cord-blood-network
#14
Simonetta Pupella, Maria Bianchi, Anna Ceccarelli, Deanna Calteri, Letizia Lombardini, Andrea Giornetti, Giuseppe Marano, Massimo Franchini, Giuliano Grazzini, Giancarlo M Liumbruno
BACKGROUND: Public cord blood banking is currently managed in Italy by a network of 19 regional cord blood banks coordinated by the National Blood Centre and the National Transplant Centre. A cost analysis was carried out within the Italian network to determine the relationship between cost of cord blood collection and banking and size of the bank inventory, which ranged from 106 to 9,341 units on December 31(st), 2012. MATERIALS AND METHODS: The 19 banks were invited to report costs incurred in 2012 related to cord blood unit collection, transportation, biological validation, characterisation, manipulation, cryopreservation, storage, data management, and general costs...
April 13, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28474347/optimization-of-cord-blood-unit-sterility-testing-impact-of-dilution-analysis-delay-and-inhibitory-substances
#15
Mélissa Girard, Audrey Laforce-Lavoie, Marie Joëlle de Grandmont, Marie-Pierre Cayer, Diane Fournier, Gilles Delage, Louis Thibault
BACKGROUND: Different methods are used by cord blood banks to prepare samples for sterility testing. Suboptimal methods can result in the release of contaminated products. In our organization, samples are prepared by diluting the final product in RPMI-1640 medium. In this work, we have compared our method with different approaches to verify whether optimization should be sought. STUDY DESIGN AND METHODS: Cord blood units (n = 6 units per bacterial strain) characterized to contain inhibitory substances or not were inoculated (10 colony-forming units/mL) with Streptococcus agalactiae, Staphylococcus epidermidis, Klebsiella pneumoniae, Escherichia coli, or Bacteroides fragilis...
August 2017: Transfusion
https://www.readbyqxmd.com/read/28456005/a-history-of-cord-blood-banking-and-transplantation
#16
Joanne Kurtzberg
No abstract text is available yet for this article.
May 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28391986/gene-products-promoting-remyelination-are-up-regulated-in-a-cell-therapy-product-manufactured-from-banked-human-cord-blood
#17
Paula Scotland, Susan Buntz, Pamela Noeldner, Arjun Saha, Tracy Gentry, Joanne Kurtzberg, Andrew E Balber
BACKGROUND AIMS: DUOC-01, a cell product being developed to treat demyelinating conditions, is composed of macrophages that arise from CD14(+) monocytes in the mononuclear cell (MNC) population of banked cord blood (CB). This article demonstrates that expression of multiple gene products that promote remyelination is rapidly up-regulated during manufacturing of DUOC-01 from either MNC or purified CB CD14(+) monocytes. METHODS: Cell cultures were initiated with MNC or with immunoselected CD14(+) monocytes isolated from the same CB unit...
April 5, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28390987/cryopreserved-cd34-cell-dose-but-not-total-nucleated-cell-dose-influences-hematopoietic-recovery-and-extensive-chronic-graft-versus-host-disease-after-single-unit-cord-blood-transplantation-in-adult-patients
#18
Takaaki Konuma, Seiko Kato, Maki Oiwa-Monna, Susumu Tanoue, Miho Ogawa, Masamichi Isobe, Arinobu Tojo, Satoshi Takahashi
Low cryopreserved total nucleated cell (TNC) dose in a cord blood (CB) unit has been shown to be associated with engraftment failure and mortality after single-unit cord blood transplantation (CBT) in adults. Although CB banks offer specific characteristics of cryopreserved cell dose, such as TNC, CD34(+) cells, and colony-forming unit for granulocyte/macrophage (CFU-GM), the impact of each cell dose on engraftment and outcomes after single-unit CBT in adults remains unclear. We retrospectively analyzed the results of 306 CBTs for 261 adult patients in our institution between 1998 and 2016...
April 5, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28388313/arachidonic-acid-and-docosahexanoic-acid-enhance-platelet-formation-from-human-apheresis-derived-cd34-cells
#19
Ankita Dhenge, Kedar Limbkar, Sameer Melinkeri, Vaijayanti Prakash Kale, Lalita Limaye
An Aberration in megakaryopoiesis and thrombopoiesis, 2 important processes that maintain hemostasis, leads to thrombocytopenia. Though platelet transfusions are used to treat this condition, blood banks frequently face a shortage of platelets. Therefore, methods to generate platelets on a large scale are strongly desirable. However, to generate megakaryocytes (MKs) and platelets (PLTs) in numbers sufficient for clinical application, it is essential to understand the mechanism of platelet production and explore efficient strategies accordingly...
May 19, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28387929/placental-passage-of-antiepileptic-drugs-at-delivery-and-neonatal-outcomes
#20
Anna M Bank, Zachary N Stowe, D Jeffrey Newport, James C Ritchie, Page B Pennell
Children of women treated with antiepileptic drugs (AEDs) are at increased risk of adverse outcomes detectable in the neonatal period, which may be associated with the amount of AEDs in the fetal circulation. Placental passage of AEDs can be measured by calculating the ratio of umbilical cord to maternal AED concentrations collected at delivery. The aims of this study were to determine the umbilical cord concentrations and umbilical-to-maternal ratios for AEDs, and whether higher cord concentrations are associated with increased risk of neonatal complications...
May 2017: Epilepsia
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