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https://www.readbyqxmd.com/read/29111891/regenerative-medicine-in-india-trends-and-challenges-in-innovation-and-regulation
#1
Shashank S Tiwari, Sujatha Raman, Paul Martin
The government of India has heavily promoted research and development in regenerative medicine together with domestic innovation and business development initiatives. Together, these promise a revolution in healthcare and public empowerment in India. Several national and transnational linkages have emerged to develop innovative capacity, most prominently in stem cell and cord blood banking, as well as in gene therapy, tissue engineering, biomaterials and 3D printing. However, challenges remain of achieving regulatory oversight, viable outputs and equitable impacts...
November 7, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29043227/the-role-of-cord-blood-banks-in-the-cell-therapy-era-future-perspectives
#2
Young-Ho Lee
No abstract text is available yet for this article.
September 2017: Blood Research
https://www.readbyqxmd.com/read/28976280/the-role-of-policies-and-networks-in-development-of-cord-blood-usage-in-china
#3
Hung-Chieh Chang
Research regarding the use of cord blood (CB) has focused on antigen match and the number of stem cells, with policies and networks related to its use being under researched. This article is based on fieldwork in China from 2013 to 2015 and examines ways that the studied CB bank enhances CB usage in China. This article identifies that in addition to finding a match, CB use is linked to the policies and networks, release fee and public awareness that enable CB usage development.
September 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28970695/interference-of-daratumumab-with-pretransfusion-testing-mimicking-a-high-titer-low-avidity-like-antibody
#4
Mei-Hwa Lin, Fei-Yun Liu, Hsiu-Mien Wang, Hsin-Ching Cho, Shyh-Chyi Lo
Daratumumab is a monoclonal immunoglobulin against CD38 and has been approved for treating patients with refractory multiple myeloma. The presence of daratumumab in the sera can interfere with pretransfusion testing due to the weakly expression of CD38 on red cells. The reactivity could be mistaken as autoantibody (if autocontrol is positive) or alloantibody (if autocontrol is negative). We present a case that demonstrates daratumumab could mimic a high titer low avidity (HTLA) alloantibody. A 34-year-old male patient of refractory myeloma was recruited in phase three clinical trial involving daratumumab...
July 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28967644/umbilical-cord-blood-banking-in-the-worldwide-hematopoietic-stem-cell-transplantation-system-perspectives-for-ukraine
#5
T O Kalynychenko
Significant progress in the promotion of procedural technologies associated with the transplantation of hematopoietic stem cells caused a rapid increase in activity. The exchange of hematopoietic stem cells for unrelated donor transplantations is now much easier due to the relevant international professional structures and organizations established to support cooperation and standard setting, as well as rules for the functioning of both national donor registries and cord blood banks. These processes are increasing every year and are contributing to the outpacing rates of development in this area...
September 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28952356/current-knowledge-and-practice-of-pediatric-providers-in-umbilical-cord-blood-banking
#6
Amy E Armstrong, Rachel Fonstad, Stephen Spellman, Zoe Tullius, Sonali Chaudhury
More than 35 000 umbilical cord blood (UCB) transplants have been performed worldwide, prompting the development of private and public banks to collect and store UCB cells. We hypothesized that pediatricians, who are uniquely poised to discuss UCB banking (UCBB) during prenatal or sibling visits, rarely do so. Through distribution of a 26-question electronic survey to general and subspecialty pediatric providers, we assessed baseline knowledge and conversations about UCBB. A total of 473 providers completed the survey; only 22% of physicians ever discussed UCBB with expectant parents...
March 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28952291/high-resolution-hla-a-typing-in-normal-iranian-population
#7
Azadeh Hadadianpour, Mohammad Hasan Samiee Aref, Sirous Zeinali
Background: Human leukocyte antigen (HLA) gene is a highly polymorphic region. HLA typing is required to match patients and donors for transplantation; therefore, development of HLA registries is necessary for finding HLA match donors. HLA system is highly informative, and numerous studies have been conducted on HLA allele distribution in different populations. Methods: In this study, 100 unrelated Iranian individuals were typed for HLA-A locus using sequence-based typing method...
September 27, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28948342/pediatric-mycosis-fungoides-a-study-of-the-human-leukocyte-antigen-system-among-israeli-jewish-patients
#8
Ofer Reiter, Dan Ben Amitai, Iris Amitay-Laish, Moshe Israeli, Lev Pavlovsky, Emmilia Hodak
Pediatric mycosis fungoides (MF) is a rare disease characterized by over-representation of atypical clinical variants, with a different prognosis from adult MF. Several human leukocyte antigen (HLA) alleles have been associated with MF in certain adult populations, including Israeli Jews. However, HLA data on pediatric MF as a group are lacking. To evaluate the possible association of the HLA system with pediatric MF, 59 Israeli Jewish patients diagnosed with MF at age ≤ 18 years underwent high- and intermediate-resolution genotyping for HLA class I (HLA-A*, HLA-B*) and class II (HLA-DRB1*, DQB1*) loci...
September 25, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28844127/direct-conversion-of-human-umbilical-cord-blood-into-induced-neural-stem-cells-with-sox2-and-hmga2
#9
Jae-Jun Kim, Ji-Hee Shin, Kyung-Rok Yu, Byung-Chul Lee, Insung Kang, Jin Young Lee, Da-Hyun Kim, Yoojin Seo, Hyung-Sik Kim, Soon Won Choi, Kyung-Sun Kang
Recent advances have shown the direct reprogramming of mouse and human fibroblasts into induced neural stem cells (iNSCs) without passing through an intermediate pluripotent state. Thus, direct reprogramming strategy possibly provides a safe and homogeneous cellular platform. However, the applications of iNSCs for regenerative medicine are limited by the restricted availability of cell sources. Human umbilical cord blood (hUCB) cells hold great potential in that immunotyped hUCB units can be immediately obtained from public banks...
August 31, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28836380/comparison-of-human-umbilical-cord-blood-processing-with-or-without-hydroxyethyl-starch
#10
Milad Souri, Mahin Nikougoftar Zarif, Mahboobeh Rasouli, Khadijeh Golzadeh, Mozhdeh Nakhlestani Hagh, Nasim Ezzati, Kamran Atarodi
BACKGROUND: Umbilical cord blood (UCB) processing with hydroxyethyl starch (HES) is the most common protocol in the cord blood banks. The quality of UCB volume reduction was guaranteed by minimum manipulation of cord blood samples in the closed system. This study aimed to analyze and compare cell recovery and viability of UCB processed using the Sepax automated system in the presence and absence of HES. STUDY DESIGN AND METHODS: Thirty UCB bags with a total nucleated cell (TNC) count of more than 2...
August 23, 2017: Transfusion
https://www.readbyqxmd.com/read/28823040/maternal-predictors-and-quality-of-umbilical-cord-blood-units
#11
Beata Bielec-Berek, Żaneta Jastrzębska-Stojko, Agnieszka Drosdzol-Cop, Cecylia Jendyk, Dariusz Boruczkowski, Tomasz Ołdak, Agnieszka Nowak-Brzezińska, Rafał Stojko
The aim of the study was to determine the relationship between the maternal age at delivery and selected properties of the cord blood stem cells. The study included 50 pregnant women aged between 18 and 38 years in which spontaneous labors or elective cesarean sections were performed. Umbilical cord blood was collected immediately after the women were delivered of newborns. The samples were analyzed in the Polish Stem Cells Bank in Warsaw. The highest mean WBC level (p < 0.05) was observed in the umbilical blood collected from patients aged 35 years and more...
August 19, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28758211/cytomegalovirus-viral-load-in-cord-blood-and-impact-of-congenital-infection-on-markers-of-hematopoietic-progenitor-cell-potency
#12
M Susana Albano, Rodica Ciubotariu, Ludy Dobrila, Michal Tarnawski, Margely DeLeon, Chiseko Watanabe, Siddarth Krishnan, Andromachi Scaradavou, Pablo Rubinstein
BACKGROUND: The low incidence of cytomegalovirus (CMV) infection in neonates decreases the risk of viral transmission with cord blood transplantation. Cord blood donors are screened by testing the maternal sample for total antibodies to CMV. Some cord blood banks also screen cord blood for CMV-DNA. The aim of this study was to develop and validate a multiplex real-time polymerase chain reaction assay to measure CMV viral load in cord blood from asymptomatic infants with congenital CMV infection and to assess the impact of CMV infection on cord blood hematopoietic progenitor cell concentrations and colony-forming unit functionality...
July 31, 2017: Transfusion
https://www.readbyqxmd.com/read/28751465/india-cracks-down-on-clinics-offering-stem-cell-therapy-and-blood-cord-banking
#13
Sumi S Dutta
No abstract text is available yet for this article.
July 27, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28731615/the-prevalence-of-ccr5-%C3%AE-32-mutation-in-a-cohort-of-saudi-stem-cell-donors
#14
M Alarifi, F Al-Amro, A Alalwan, A Al-Turki, H Fakhoury, N Atallah, M Al-Muallimi, M Al-Balwi, M Alzahrani, A Alaskar, A Hajeer, D Jawdat
CCR5 is a chemokine receptor that was found to be used by HIV as a co-receptor for entering target cells. A 32 bp deletion was described in certain people that rendered CCR5 non-functional. The mutant allele CCR5-Δ32 has been shown to prevent HIV infection. In addition, stem cell transplantation with the CCR5-Δ32 homozygous genotype can lead to clearance of HIV infection. In this study, our aim was to investigate the frequency of CCR5-Δ32 mutation in a cohort of stem cell donors from cord blood bank and stem cell donor registry...
July 21, 2017: HLA
https://www.readbyqxmd.com/read/28716596/quality-comparison-of-umbilical-cord-blood-cryopreserved-with-conventional-versus-automated-systems
#15
Kyeong Mi Kim, Ji Young Huh, Jin Ju Kim, Myung Seo Kang
Umbilical cord blood (CB) banks usually freeze and store CB for clinical transplantation using conventional controlled-rate freezer or the automated BioArchive system. The aim of this study is to compare the quality of CB cryopreserved with conventional and automated methods and to make clear the cause of the quality difference between the two methods. The experiment used 80 CB units: 40 were conventionally cryopreserved and the remainder were cryopreserved with a BioArchive. After thawing, the following measures of CB quality were compared: recovery rates of cell count, cell viability of total nucleated cells (TNCs), mononuclear cells (MNCs), and CD34+ cells, as well as colony-forming unit-granulocyte/macrophage (CFU-GM) content...
July 14, 2017: Cryobiology
https://www.readbyqxmd.com/read/28711452/hematopoietic-stem-cell-transplantation-in-algeria
#16
REVIEW
Mohamed Amine Bekadja, Mohamed Brahimi, Soufi Osmani, Nabil Yafour, Amina Krim, Faiza Serradj, Souad Talhi, Kamila Amani, Rachid Amar Bouhass
INTRODUCTION: Algeria is a country of 40,.4 million inhabitants and half of which is under 30years. In Algeria, Health-care insurance covered, 90% of the population. Health care is free and it is supported by the Ministry of Health. 16 university hospitals exist in Algeria and only two (Algiers and Oran) practicing bone marrow transplant. Adult hematologic malignancies account for 10% (about 4000 new cases/year) of the malignancy affecting in most cases young patients under 65years of age...
July 11, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28687394/umbilical-cord-blood-cytomegalovirus-serostatus-does-not-have-an-impact-on-outcomes-of-umbilical-cord-blood-transplantation-for-acute-leukemia
#17
Olga Nikolajeva, Vanderson Rocha, Robert Danby, Annalisa Ruggeri, Fernanda Volt, Etienne Baudoux, Susana G Gomez, Gezine Kögler, Jerome Larghero, Lucilla Lecchi, Mar Sanchez Martinez, Cristina Navarrete, Fabienne Pouthiers, Sergio Querol, Chantal Kenzey, Richard Szydlo, Eliane Gluckman, Alejandro Madrigal
Several studies have reported an impact of adult hematopoietic stem cell donor cytomegalovirus (CMV) serostatus on allogeneic hematopoietic cell transplantation outcomes. Limited data, however, are available on the impact of cord blood unit (CBU) CMV serostatus on allogeneic umbilical cord blood transplantation (UCBT) outcomes. We analyzed, retrospectively, the impact of CBU CMV serostatus on relapse incidence (RI) and 2-year nonrelapse mortality (NRM) of single-unit CBU transplantation for acute leukemia. Data from 1177 de novo acute leukemia pediatric and adult patients transplanted within European Group for Blood and Marrow Transplantation centers between 2000 and 2012 were analyzed...
July 4, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28680446/donor-selection-for-allogenic-hemopoietic-stem-cell-transplantation-clinical-and-ethical-considerations
#18
REVIEW
Irene Riezzo, Natascha Pascale, Raffaele La Russa, Arcangelo Liso, Monica Salerno, Emanuela Turillazzi
Allogenic hematopoietic progenitor cell transplantation (allo-HSCT) is an established treatment for many diseases. Stem cells may be obtained from different sources: mobilized peripheral blood stem cells, bone marrow, and umbilical cord blood. The progress in transplantation procedures, the establishment of experienced transplant centres, and the creation of unrelated adult donor registries and cord blood banks gave those without an human leucocyte antigen- (HLA-) identical sibling donor the opportunity to find a donor and cord blood units worldwide...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28653354/a-new-strategy-for-umbilical-cord-blood-collection-developed-at-the-first-colombian-public-cord-blood-bank-increases-total-nucleated-cell-content
#19
Diana Vanegas, Lady Triviño, Cristian Galindo, Leidy Franco, Gustavo Salguero, Bernardo Camacho, Ana-María Perdomo-Arciniegas
BACKGROUND: The total nucleated cell dosage of umbilical cord blood (UCB) is an important factor in determining successful allogeneic hematopoietic stem cell transplantation after a minimum human leukocyte antigen donor-recipient match. The northern South American population is in need of a new-generation cord blood bank that cryopreserves only units with high total nucleated cell content, thereby increasing the likelihood of use. Colombia set up a public cord blood bank in 2014; and, as a result of its research for improving high total nucleated cell content, a new strategy for UCB collection was developed...
September 2017: Transfusion
https://www.readbyqxmd.com/read/28492861/vena-cava-filter-use-in-trauma-and-rates-of-pulmonary-embolism-2003-2015
#20
MULTICENTER STUDY
Alan D Cook, Brian W Gross, Turner M Osler, Katelyn J Rittenhouse, Eric H Bradburn, Steven R Shackford, Frederick B Rogers
Importance: Vena cava filter (VCF) placement for pulmonary embolism (PE) prophylaxis in trauma is controversial. Limited research exists detailing trends in VCF use and occurrence of PE over time. Objective: To analyze state and nationwide temporal trends in VCF placement and PE occurrence from 2003 to 2015 using available data sets. Design, Setting, and Participants: A retrospective trauma cohort study was conducted using data from the Pennsylvania Trauma Outcome Study (PTOS) (461 974 patients from 2003 to 2015), the National Trauma Data Bank (NTDB) (5 755 095 patients from 2003 to 2014), and the National (Nationwide) Inpatient Sample (NIS) (24 449 476 patients from 2003 to 2013) databases...
August 1, 2017: JAMA Surgery
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