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https://www.readbyqxmd.com/read/29766665/identification-of-the-novel-hla-drb1-allele-drb1-14-183-in-a-colombian-umbilical-cord-blood-bank-donor
#1
L-X González-Acero, B Camacho, A M Perdomo-Arciniegas
HLA-DRB1*14:183 has two nucleotide changes from HLA-DRB1-13:44, D to E and F to Y. This article is protected by copyright. All rights reserved.
May 15, 2018: HLA
https://www.readbyqxmd.com/read/29765424/public-awareness-on-cord-blood-banking-in-saudi-arabia
#2
Dunia Jawdat, Sulaiman AlTwijri, Hadeel AlSemari, Mayssa Saade, Ahmed Alaskar
Background: In the last decade, cord blood (CB) has proven to be a valuable source of hematopoietic stem cells for transplantation to treat many hematological disorders. Since then, many CB banks have been established worldwide. Our aim was to estimate the level of public awareness of CB banking in Saudi Arabia. Study Design and Methods: A self-administered questionnaire of 22 multiple choices was conveniently distributed, consisting of demographics, awareness measure, attitude toward banking preference, and donation for research data...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29752869/allogeneic-umbilical-cord-blood-infusion-for-adults-with-ischemic-stroke-clinical-outcomes-from-a-phase-1-safety-study
#3
Daniel T Laskowitz, Ellen R Bennett, Rebecca J Durham, John J Volpi, Jonathan R Wiese, Michael Frankel, Elizabeth Shpall, Jeffry M Wilson, Jesse Troy, Joanne Kurtzberg
Stroke is a major cause of death and long-term disability, affecting one in six people worldwide. The only currently available approved pharmacological treatment for ischemic stroke is tissue plasminogen activator; however, relatively few patients are eligible for this therapy. We hypothesized that intravenous (IV) infusion of banked unrelated allogeneic umbilical cord blood (UCB) would improve functional outcomes in patients with ischemic stroke. To investigate this, we conducted a phase 1 open-label trial to assess the safety and feasibility of a single IV infusion of non-human leukocyte antigen (HLA) matched, ABO matched, unrelated allogeneic UCB into adult stroke patients...
May 12, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29752867/topical-application-of-culture-expanded-cd34-umbilical-cord-blood-cells-from-frozen-units-accelerates-healing-of-diabetic-skin-wounds-in-mice
#4
Jennifer Whiteley, Theresa Chow, Hibret Adissu, Armand Keating, Ian M Rogers
Chronic and nonhealing wounds are constant health issues facing patients with type 2 diabetes. As the incidence of type 2 diabetes mellitus (T2DM) increases, the incidence of chronic wounds and amputations will rise. T2DM is associated with peripheral arterial occlusive disease, which leads to the development of nonhealing skin ulcers after minor trauma. Patients develop severe pain limiting their mobility and ability to work and take care of themselves thus putting a significant burden on the family and society...
May 12, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29737201/effects-of-cryopreservation-duration-on-the-outcome-of-single-unit-cord-blood-transplantation
#5
Tang-Her Jaing, Shih-Hsiang Chen, Yu-Chuan Wen, Tsung-Yen Chang, Ya-Chun Yang, Pei-Kwei Tsay
Cryopreservation is widely used in umbilical cord blood (UCB) banking, yet its impact on progenitor cell function remains largely unaddressed. It is unknown whether long-term cryopreservation affects UCB transplantation outcomes. Herein, we evaluated the impact of UCB age on clinical outcomes and investigated the effect of cryopreservation duration of UCB on hematopoietic potency in 91 patients receiving single cord blood transplantations. UCB cryopreservation duration was 0.7 to 13.4 y. The most common indication of transplant was thalassemia (48%)...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29666679/intrauterine-fetal-blood-transfusion-descriptive-study-of-the-first-four-years-experience-in-oman
#6
Arwa Z Al-Riyami, Mouza Al-Salmani, Sabria N Al-Hashami, Sabah Al-Mahrooqi, Ali Al-Marhoobi, Sumaiya Al-Hinai, Saif Al-Hosni, Sathiya M Panchatcharam, Zainab A Al-Arimi
Objectives: Haemolytic disease of the fetus and newborn (HDFN) causes hydrops fetalis . The successful treatment of HDFN has been reported with intrauterine blood transfusion (IUT). This study aimed to describe the initial experience with IUT procedures in Oman. Methods: This retrospective observational study took place at the Royal Hospital and Sultan Qaboos University Hospital Blood Bank, Muscat, Oman, and included all women who underwent IUT procedures in Oman between March 2012 and March 2016...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29660452/simulation-of-non-inherited-maternal-antigens-acceptable-hla-mismatches-to-increase-the-chance-of-matched-cord-blood-units-hong-kong-s-experience
#7
Janette Kwok, Mengbiao Guo, Wanling Yang, Patrick Ip, C K Lee, Liwei Lu, Godfrey C F Chan, Derek Middleton, Henk G M van der Zanden
In Cord blood transplantation (CBT), the non-inherited maternal antigen (NIMA) virtual six HLA matched CB is found to have similar outcomes to six HLA inherited matched CB. Such virtual HLA matched CB units can be generated by substituting the inherited alleles with one to three NIMAs. In Hong Kong Cord Blood Bank, CB units have no NIMA defined. 100 CB samples were collected with NIMA defined. Retrospective searches of Hong Kong patients (n = 520) were matched against the inherited and virtual HLA phenotypes of NIMA CB file...
April 13, 2018: Human Immunology
https://www.readbyqxmd.com/read/29607499/assessing-opportunities-and-challenges-for-establishing-a-national-program-to-distribute-cord-blood-for-research
#8
Rosario Isasi, Cherie Mastronardi, Mia Golder, David Allan, Mark Walker, Mike Halpenny, Lin Yang, Heidi Elmoazzen, Sophie Chargé
BACKGROUND: Research is needed to enhance cord blood (CB) transplantation outcomes and to develop new clinical applications. Based on quality criteria for transplantation, CB collected by public CB banks (CBBs) is often unsuitable for banking, but may still be valuable for research. Canadian researchers have described a need for a centralized program providing ethically sourced CB for research projects. To meet this need, Canadian Blood Services (CBS), in partnership with The Ottawa Hospital, launched the Cord Blood for Research Program (CBRP) in 2014...
April 1, 2018: Transfusion
https://www.readbyqxmd.com/read/29574750/impact-of-delayed-umbilical-cord-clamping-on-public-cord-blood-donations-can-we-help-future-patients-and-benefit-infant-donors
#9
Rodica Ciubotariu, Andromachi Scaradavou, Ilinca Ciubotariu, Michal Tarnawski, Sara Lloyd, Maria Albano, Ludy Dobrila, Pablo Rubinstein, Amos Grunebaum
BACKGROUND: Cord blood (CB) is a widely accepted stem cell source and its clinical utilization depends, to a great extent, on its cell content. Birth-to-clamping (BTC) time of umbilical cord determines placental transfusion to the newborn, and the remaining blood that can be collected and banked. The 2017 Committee Opinion of the American College of Obstetrics and Gynecologists (ACOG) recommends a delay of "at least 30-60 seconds" before clamping the cord for all newborns to ensure adequate iron stores...
March 25, 2018: Transfusion
https://www.readbyqxmd.com/read/29556970/concepts-utility-and-limitations-of-cord-blood-banking-what-clinicians-need-to-know
#10
Dhanya Lakshmi Narayanan, Shubha R Phadke
Stem cell transplantation and cord blood banking have received much popularity among general public and medical professionals in the recent past. But information about the scientific aspects, its utility and limitations is incomplete amongst laypersons as well as many medical practitioners. Stem cells differ from all other types of cells in the human body because of their ability to multiply in order to self perpetuate and differentiate into specialized cells. Stems cells could be totipotent, multipotent, pluripotent, oligopotent or unipotent depending on the type of cells that can arise or differentiate from them...
March 20, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29546777/luminex-%C3%A2-xmap-%C3%A2-technology-is-an-effective-strategy-for-high-definition-human-leukocyte-antigen-typing-of-cord-blood-units-prior-to-listing
#11
Marco Guarene, Carla Badulli, Anna L Cremaschi, Ilaria Sbarsi, Rosalia Cacciatore, Carmine Tinelli, Annamaria Pasi, Paola Bergamaschi, Cesare G Perotti
INTRODUCTION: Allele-level donor-recipient match at HLA-A, HLA-B, HLA-C and HLA-DRB1 loci impacts the outcome after cord blood transplantation for hematologic malignancies and modifies the strategy of donor selection. High definition of both class I and II HLA loci at time of listing is a way to improve the attractiveness of cord blood bank inventories, reducing the time for donor search and procurement and simplifying donor choice, in particular, for patients of non-European heritage...
March 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29516509/development-of-a-proof-of-principle-for-universal-neutralization-of-antibiotics-in-cord-blood-by-products-used-for-sterility-testing
#12
Yuntong Kou, Mike Halpenny, Heidi Elmoazzen, Sandra Ramirez-Arcos
BACKGROUND: Bacterial contamination of cord blood (CB) represents a safety risk for transplantation patients. CB sterility testing at Canadian Blood Services' Cord Blood Bank is performed using a 1:1 mix of CB-derived plasma and red blood cells (RBCs). Culture bottles of an automated culture system, which lack antimicrobial neutralization properties, are used for bacterial screening of CB. This process is unsuitable for CB-containing antibiotics, potentially resulting in false-negative results...
March 7, 2018: Transfusion
https://www.readbyqxmd.com/read/29460118/feasibility-of-cord-blood-bank-in-high-altitude-abha-preclinical-impacts
#13
Harish C Chandramoorthy, Abdulmajeed Mohammed Bajunaid, Hussian Nasser Kariri, Ahmed Al-Hakami, Abdullah Abu Sham, Misfer Bin Safer Al-Shahrani, Suliman M Al-Humayed, Prasanna Rajagopalan
We explored the possibility of the cryo-storage of cord blood hematopoietic stem cells (CBHPSC) with respect to the quantity, quality and biologic efficacy of high altitude (HA) region Abha against sea level (SL) region. The results of the post-processed total nucleated cell count was 8.03 ± 0.31 × 107 and 8.44 ± 0.23 × 107 cells in the HA and SL regions respectively. The mean post processing viability of the nucleated cells was about 87.03 ± 1.39 (HA) and 88.33 ± 1.55% (SL) while post thaw cells were 85...
February 19, 2018: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29429941/quantitative-analysis-of-composite-umbilical-cord-tissue-health-using-a-standardized-explant-approach-and-an-assay-of-metabolic-activity
#14
Matthew L Skiles, Katherine S Brown, William Tatz, Kristen Swingle, Heather L Brown
BACKGROUND: Umbilical cord (UC) tissue can be collected in a noninvasive procedure and is enriched in progenitor cells with potential therapeutic value. Mesenchymal stromal cells (MSCs) can be reliably harvested from fresh or cryopreserved UC tissue by explant outgrowth with no apparent impact on functionality. A number of stem cell banks offer cryopreservation of UC tissue, alongside cord blood, for future cell-based applications. In this setting, measuring and monitoring UC quality is critical...
April 2018: Cytotherapy
https://www.readbyqxmd.com/read/29421958/treating-childhood-traumatic-brain-injury-with-autologous-stem-cell-therapy
#15
Shyam Dewan, Samantha Schimmel, Cesar V Borlongan
Neonatal traumatic brain injury (TBI) is a significant cause of developmental disorders. Autologous stem cell therapy may enhance neonatal brain plasticity towards repair of the injured neonatal brain. Areas covered: The endogenous neonatal anti-inflammatory response can be enhanced through the delivery of anti-inflammatory agents. Stem cell therapy stands as a robust approach for sequestering the inflammation-induced cell death in the injured brain. Here, we discuss the use of umbilical cord blood cells and bone marrow stromal cells for acute and chronic treatment of experimental neonatal TBI...
February 15, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29277913/unrelated-donor-choices-for-allogeneic-hematopoietic-cell-transplantation-in-canada-an-evaluation-of-factors-influencing-donor-selection
#16
Valerie Greco-Stewart, Jeffrey Kiernan, Donna Killeen, Sherry Haun, Dena Mercer, Kimberly Young, Robert S Liwski, David S Allan
BACKGROUND: Utilization of unrelated donors and cord blood units (CBUs) for allogeneic hematopoietic cell transplantation continues to increase. Understanding the practices of donor selection by transplant centers is critical for unrelated donor registries and cord blood banks to optimize registry composition and inventory to meet patient need. STUDY DESIGN AND METHODS: Unrelated donor and CBU selection practices of Canadian transplant centers served by Canadian Blood Services' OneMatch Stem Cell & Marrow Network (OM) were reviewed, including HLA match level, locus of disparity, age, sex, and product choice (donor vs...
March 2018: Transfusion
https://www.readbyqxmd.com/read/29274116/risk-of-hla-homozygous-cord-blood-transplantation-implications-for-induced-pluripotent-stem-cell-banking-and-transplantation
#17
Yasuo Morishima, Fumihiro Azuma, Koichi Kashiwase, Kayoko Matsumoto, Takeshi Orihara, Hiromasa Yabe, Shunichi Kato, Koji Kato, Shunro Kai, Tetsuo Mori, Kazunori Nakajima, Satoko Morishima, Masahiro Satake, Minoko Takanashi, Toshio Yabe
Clinical application of induced pluripotent stem cells (iPS) in autologous settings has just begun. To overcome the high time and cost barriers in the individual production of autologous iPS, the use of allogeneic iPS with a homozygous human leukocyte antigen (HLA) haplotype (HLA-homo HP) has been proposed. Cord blood transplantation (CBT) is a suitable model for evaluating the allogeneic immunogenicity of iPS transplantation from HLA-homo donors. We analyzed 1,374 Japanese single cord blood transplant pairs who were retrospectively typed as HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1...
February 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29234598/investigating-structural-and-perfusion-deficits-due-to-repeated-head-trauma-in-active-professional-fighters
#18
Virendra Mishra, Karthik Sreenivasan, Sarah J Banks, Xiaowei Zhuang, Zhengshi Yang, Dietmar Cordes, Charles Bernick
Repeated head trauma experienced by active professional fighters results in various structural, functional and perfusion damage. However, whether there are common regions of structural and perfusion damage due to fighting and whether these structural and perfusion differences are associated with neuropsychological measurements in active professional fighters is still unknown. To that end, T1-weighted and pseudocontinuous arterial spin labeling MRI on a group of healthy controls and active professional fighters were acquired...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29194667/evaluation-of-the-impact-of-banking-umbilical-cord-blood-units-with-high-cell-dose-for-ethnically-diverse-patients
#19
Gretta Stritesky, Kimberly Wadsworth, Merry Duffy, Kelly Buck, Jason Dehn
BACKGROUND: Umbilical cord blood units provide an important stem cell source for transplantation, particularly for patients of ethnic diversity who may not have suitably matched available, adult-unrelated donors. However, with the cost of cord blood unit acquisition from public banks significantly higher than that for adult-unrelated donors, attention is focused on decreasing cost yet still providing cord blood units to patients in need. Historical practices of banking units with low total nucleated cell counts, including units with approximately 90 × 107 total nucleated cells, indicates that most banked cord blood units have much lower total nucleated cell counts than are required for transplant...
February 2018: Transfusion
https://www.readbyqxmd.com/read/29163938/understanding-biological-mechanisms-underlying-adverse-birth-outcomes-in-developing-countries-protocol-for-a-prospective-cohort-amanhi-bio-banking-study
#20
Abdullah H Baqui, Rasheda Khanam, Mohammad Sayedur Rahman, Aziz Ahmed, Hasna Hena Rahman, Mamun Ibne Moin, Salahuddin Ahmed, Fyezah Jehan, Imran Nisar, Atiya Hussain, Muhammad Ilyas, Aneeta Hotwani, Muhammad Sajid, Shahida Qureshi, Anita Zaidi, Sunil Sazawal, Said M Ali, Saikat Deb, Mohammed Hamad Juma, Usha Dhingra, Arup Dutta, Shaali Makame Ame, Caroline Hayward, Igor Rudan, Mike Zangenberg, Donna Russell, Sachiyo Yoshida, Ozren Polašek, Alexander Manu, Rajiv Bahl
Objectives: The AMANHI study aims to seek for biomarkers as predictors of important pregnancy-related outcomes, and establish a biobank in developing countries for future research as new methods and technologies become available. Methods: AMANHI is using harmonised protocols to enrol 3000 women in early pregnancies (8-19 weeks of gestation) for population-based follow-up in pregnancy up to 42 days postpartum in Bangladesh, Pakistan and Tanzania, with collection taking place between August 2014 and June 2016...
December 2017: Journal of Global Health
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