Comorbitity

BACKGROUND: Life expectancy for people with CF (PwCF) continues to increase. However, a trend of overweight and obesity is emerging along with concern of developing comorbitities. Body composition (BC) is associated with several health indices. However, body mass index (BMI) does not provide information on BC. METHODS: BMI, fat mass (FM), fat free mass (FFM), using bioelectrical impedance, lung function and sweat chloride (SwCl) were assessed in adult PwCF in routine clinic before and after commencement of the CFTR modulator Elexacaftor/Tezacaftor/Ivacaftor...

Löffler endocarditis is an uncommon, but known complication of hypereosinophilic syndrome (HES). It is a relatively rare entity, and remains poorly understood. To this point in time, the compendium of knowledge about this disease consists of various case reports, prospective studies and review articles. We aim to present a scoping study about this disease. Our goals are to identify the characteristic features found in case reports to identify characteristic features found in patients with Löffler endocarditis as a result of hypereosinophilic syndrome...

Old patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. We sought for the distinctive characteristics of DILI in older patients across age groups. A total of 882 DILI patients included in the Spanish DILI Registry (33% ≥65 years) were categorized according to age: "young" (<65y); "young-old" (65-74y); "middle-old" (75-84y); and "oldest-old" (≥85y). All elderly groups had increasingly higher comorbidity burden (p<0...

Background: Supercapsular Percutaneously Assisted total hip arthroplasty (SuperPATH approach) is a relatively new minimal invasive approach which has been associated with encouraging postoperative outcomes. The aim of this study is to compare the minimal invasive (MIS) SuperPATHapproach with the standard modified Hardinge approach at the base of muscle damage due to serum markers, functional results and other perioperative and postoperative data. Material and methods: Forty eight (48) consecutive patients undergone primary total hip arthroplasty (THA) by the same surgeon (GD), were enrolled in our study...

Obesity is a major public health burden associated with neuropsychiatric comorbidities leading to social and occupational impairment. Given the growing prevalence of both obesity and mental disorders worldwide, understanding the risk factors of obesity-related neuropsychiatric comorbidities is crucial to develop preventive strategies and individualized treatments. Recent findings suggest that adiposity-driven inflammation contributes to neuropsychiatric comorbidities in obesity. However, not all obese subjects afflicted with chronic inflammation develop neuropsychiatric symptoms, suggesting additional risk factors...

The association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) has been suggested, apart from their common epidemiological and immunological patterns, also due to observations of increased incidence of both IBD among MS patients and MS among IBD patients. We estimated the risk of concurrent IBD and MS comorbidity, using data from all available case-control studies. We calculated the corresponding Risk ratios (RRs) in each included case-control study to express the risk of IBD and MS concurrence at a given population...

The association of rhinitis with asthma symptoms in children is thought to be part of the united airway disease's theory which proposed three possible explanatory pathophysiological mechanisms: postnasal dripping, naso-bronchial reflex and systemic immune response. However, it is not clear if the relation is a co-morbid, precipitating or triggering condition or an epiphenomenon as an integrated part of the disease. In an attempt to evaluate the association, a review of all articles that were published in the last 10 years which referred to the relation of childhood rhinitis with asthma were analysed, whereas the recent knowledge on physiology and phenotype was reported as background...

The comorbidity of dermatological diseases with emotional and mental problems and common neuro-immuno-endocrine mechanisms for those disorders became a basis for formation of psychodermatology. The aim of this study is to present the objectives and actions taken by the field of psychodermatology and presentation of selected aspects of psychosocial problems in chronic dermatological diseases based on the example of psoriasis. The analysis of publications related to the subject confirmed the usefulness of psychodermatology activities...

In general, elderly patients have poorer outcomes than younger patients after intensive care treatment. Diagnosis at admission and high age mainly influence short-term mortality within the first few months after intensive care, while comorbitities and functional status are more pivotal regarding long-term mortality. Furthermore, the main reasons for reduced physical fitness and neurocognitive consequences that often last for many months after intensive care treatment of older patients are described. Many outcome studies show that physical und mental sequelae after intensive care treatment are not only substantial but also unpredictable...

A super-obese patient who suffered from severe sleep apnea (SSA) and other comorbidities underwent insertion of a BioEnterics intragastric balloon (BIB) before bariatric surgery. During the night, he was victim of cardiac arrest. After cardiopulmonary resuscitation and return of spontaneous circulation, he was transferred to intensive care unit. Two hours later, he developed an unexpected symptomatic bradycardia, and BIB was removed. The patient had no further cardiac complications, but he had a poor neurological outcome...

Dissatisfaction after total hip arthroplasty (THA) is linked to complications due to comorbitities, radiographic loosening, and poor prosthetic alignment. However, some patients have functional problems without obvious causes. This study elucidated soft tissue abnormalities that may lead to THA dysfunction and assessed the efficacy of customized physical therapeutic modalities. Seventy-eight THA patients complaining of poor functionality capabilities at 3 months after index THA were studied with a detailed physical examination and gait analysis with videotape, 3-dimensional gait studies, and isokinetic strength assessments used when necessary...

The study examines selection for kidney transplantation and determines who are referred, how many had contraindications and whether comorbidity indices predict transplant status. Of 113 consecutive adult incident end-stage renal disease (ESRD) patients at this single center 47 (41.6%) were referred. Using published guidelines, 48 (42.5%) had a specific contraindication. However 26 (23%) were neither referred nor had contraindications. An ESRD mortality score, acute renal failure status and albumin were independent predictors of referral but only the mortality score was predictive of contraindication status...

With the significant increase of the average lifespan in the industrial world, the number of elderly people, as a proportion of the total population, has risen dramatically. It has been estimated that this trend will accelerate and that, by the year 2020, the number of people aged >80 years will soar by 135%. With age being the greatest risk factor for prostate cancer, this disease has understandably become one of the greatest public health concerns. Recently, considerable attention has been focused on prostate cancer management in the elderly, with specific emphasis on the question of whether, or not, it should differ from that of younger patients...

STUDY OBJECTIVES: To describe the characteristics and outcomes of patients admitted to intermediate-care areas (ICAs) and to compare them with those of ICU patients who receive monitoring only on day 1 and are at a low risk (i.e., < 10%) for receiving subsequent active life-supporting therapy (i.e., low-risk monitor patients). DESIGN: Nonrandomized, retrospective, cohort study. SETTING: Thirteen US teaching hospitals and 19 nonteaching hospitals...

Chronic hepatitis C is now a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma. In March 1997, the National Institutes of Health sponsored a Consensus Development Conference entitled "Management of Hepatitis C". The final statement from the Consensus Panel set forth clear, evidence-based guidelines and recommendations regarding the diagnosis, evaluation, prevention and therapy of hepatitis C. The conclusions of the Consensus Panel have been widely accepted and have brought some degree of uniformity to the management of hepatitis C...