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https://www.readbyqxmd.com/read/29345111/association-between-hepatitis-c-infection-in-thai-patients-with-oral-lichen-planus-a-case-control-study
#1
Trin Manomaivat, Surawut Pongsiriwet, Chatsri Kuansuwan, Wacharaporn Thosaporn, Kathawut Tachasuttirut, Anak Iamaroon
AIM: The aim of the present study was to investigate the prevalence of hepatitis C virus (HCV) infection and evaluate liver enzyme levels in patients from upper northern Thailand with oral lichen planus (OLP). METHODS: A case-control study of 101 patients with OLP and 101 patients without OLP was conducted. Peripheral blood was taken from each patient and screened for anti-HCV antibody using immunochromatography. Positive samples were further confirmed using chemiluminescent microparticle immunoassay (CMIA) and reverse transcription-polymerase chain reaction...
January 18, 2018: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29344609/generalized-lichen-nitidus-following-anti-pd-1-antibody-treatment
#2
Maria Cho, Yumi Nonomura, Yo Kaku, Teruki Dainichi, Atsushi Otsuka, Kenji Kabashima
No abstract text is available yet for this article.
January 17, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29343507/early-and-sustained-efficacy-with-apremilast-monotherapy-in-biological-na%C3%A3-ve-patients-with-psoriatic-arthritis-a-phase-iiib-randomised-controlled-trial-active
#3
Peter Nash, Kamal Ohson, Jessica Walsh, Nikolay Delev, Dianne Nguyen, Lichen Teng, Juan J Gómez-Reino, Jacob A Aelion
OBJECTIVE: Evaluate apremilast efficacy across various psoriatic arthritis (PsA) manifestations beginning at week 2 in biological-naïve patients with PsA. METHODS: Patients were randomised (1:1) to apremilast 30 mg twice daily or placebo. At week 16, patients whose swollen and tender joint counts had not improved by ≥10% were eligible for early escape. At week 24, all patients received apremilast through week 52. RESULTS: Among 219 randomised patients (apremilast: n=110; placebo: n=109), a significantly greater American College of Rheumatology 20 response at week 16 (primary outcome) was observed with apremilast versus placebo (38...
January 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29341310/critical-appraisal-of-the-oxidative-stress-pathway-in-vitiligo-a-systematic-review-and-meta-analysis
#4
REVIEW
R Speeckaert, J Dugardin, J Lambert, H Lapeere, E Verhaeghe, M M Speeckaert, N van Geel
BACKGROUND: The pathogenesis of vitiligo remains a topic of extensive debate. This is partly due to the moderate efficacy of current treatments. The role of oxidative stress pathway in vitiligo is a popular although controversial research topic. OBJECTIVE: To clarify the role of the oxidative stress pathway in vitiligo compared to other inflammatory skin disorders and to assess the therapeutic role of antioxidants. METHODS: We conducted a systematic search of the existing literature on the aberrancies of the oxidative stress pathway in vitiligo...
January 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29341265/cicatricial-alopecia-research-foundation-meeting-may-2016-progress-towards-the-diagnosis-treatment-and-cure-of-primary-cicatricial-alopecias
#5
John P Sundberg, Maria K Hordinsky, Wilma Bergfeld, Yolanda M Lenzy, Amy J McMichael, Angela M Christiano, Tracy McGregor, Kurt S Stenn, Raja K Sivamani, C Herbert Pratt, Lloyd E King
Primary Cicatricial Alopecias (PCAs) are a group of skin diseases in which there is progressive and permanent destruction of hair follicles followed by replacement with fibrous tissue. Unfortunately, by the time patients seek clinical evaluation of their hair loss, the skin is already inflamed and/or scarred, so there is little hope for a return to their normal hair growth pattern. Clinical and basic science investigations are now focusing on three forms of human PCA, lichen planopilaris (LPP), frontal fibrosing alopecia (FFA), and central centrifugal cicatricial alopecia (CCCA)...
January 16, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29341216/primary-scarring-alopecia-a-retrospective-study-of-89-patients-in-taiwan
#6
Hsing-Jou Su, An-Yu Cheng, Cheng-Han Liu, Chia-Bau Chu, Chaw-Ning Lee, Chao-Kai Hsu, Julia Yu-Yun Lee, Chao-Chun Yang
Primary scarring alopecia (PSA) is caused by irreversible damage to the hair epithelial stem cells that reside in hair follicles. There is limited published work regarding PSA amongst the Asian population. The aim of this study was to evaluate the clinical features and to characterize the subtypes of PSA in southern Taiwan. In this retrospective case series, we reviewed 89 patients with pathology-confirmed PSA. The data was collected from National Cheng Kung University Hospital between 1988 through 2016. The clinical and histological data were reviewed, and the patients were characterized into different subtypes of PSA based on the clinical features and histological findings...
January 16, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29340709/-lichen-sclerosus-symptoms-diagnosis-therapeutic-procedures
#7
REVIEW
G Kirtschig
Lichen sclerosus is a chronic, inflammatory dermatosis that usually affects the anogenital area. Early diagnosis and subsequent long-term anti-inflammatory treatment may reduce symptoms and signs and the risk of a mutilating course and the development of carcinomas.
January 16, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29339071/mir-155-5p-promotes-fibroblast-cell-proliferation-and-inhibits-foxo-signaling-pathway-in-vulvar-lichen-sclerosis-by-targeting-foxo3-and-cdkn1b
#8
Lina Ren, Yi Zhao, Xiaoxi Huo, Xin Wu
Vulvar lichen sclerosis (VLS) is a chronic inflammatory skin disorder. Evidence is accumulating that microRNAs (miRNAs) exert crucial roles in initiation and development of a wide range of human diseases. MiR-155-5p has been frequently reported to be implicated in the tumorigenesis and progression of multiple types of cancers, however, its biological role in VLS remains unclear. This study aimed to explore the role of miR-155-5p in VLS and clarify the potential molecular mechanisms involved. In the present study, miR-155-5p was observed to be significantly upregulated in VLS tissues...
January 12, 2018: Gene
https://www.readbyqxmd.com/read/29336317/association-between-helicobacter-pylori-infection-and-vulvar-lichen-sclerosus-a-clinical-comparative-study
#9
Stefano Basile, Sara Pinelli, Pierluigi Benedetti Panici, Roberto Angioli, Francesco Plotti, Diana Giannarelli, Roldano Fossati, Carlo Maria Rosati, Maria Giovanna Salerno
No abstract text is available yet for this article.
January 16, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29335758/toxicity-of-diclofenac-in-the-fern-azolla-filiculoides-and-the-lichen-xanthoria-parietina
#10
Andrea Vannini, Luca Paoli, Marco Vichi, Martin Bačkor, Miriam Bačkorová, Stefano Loppi
This study investigated the occurrence of toxicity, expressed as damage to the photosynthetic apparatus, in the aquatic fern Azolla filiculoides and the lichen Xanthoria parietina following treatments with diclofenac at different concentrations (0.1, 1, 10 and 100 mg/L) and different exposure times (24, 48, 72 and 240 h). Measurements of photosynthetic efficiency, chlorophyll content and chlorophyll degradation indicated dose- and time-dependent toxicity, since significant differences with control samples as well as among treatments, emerged mainly for the highest concentration (100 mg/L) and the longest time (240 h)...
January 16, 2018: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29335479/lps-induced-vitamin-d-receptor-decrease-in-oral-keratinocytes-is-associated-with-oral-lichen-planus
#11
Bin Zhao, Ran Li, Fang Yang, Feiyan Yu, Na Xu, Fang Zhang, Xuejun Ge, Jie Du
The suppressive function of vitamin D on oral lichen planus (OLP) have been documented previously. Vitamin D receptor (VDR) expression is down-regulated in OLP, but the molecular mechanism of its decrease and the related anti-inflammatory contributor of epithelial VDR signaling is unclear. Herein, we demonstrated that lipopolysaccharide (LPS) remarkedly down-regulated VDR expression of keratinocytes, and the reduced regulation was dependent on tumor necrosis factor alpha (TNFα)-miR-346 pathway. In human specimen studies, VDR levels of oral mucosal epithelia from OLP patients decreased substantially accompanied with robust TNFα and miR-346 induction, compared to the normal tissues...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29333380/anti-obesity-property-of-lichen-thamnolia-vermicularis-extract-in-3t3-l1-cells-and-diet-induced-obese-mice
#12
Ra-Yeong Choi, Ju Ri Ham, Jiyoung Yeo, Jae-Seoun Hur, Seok-Kyu Park, Myung-Joo Kim, Mi-Kyung Lee
Thamnolia vermicularis (TV) is an edible lichen that is prevalent in the alpine zone of East Asia. This study evaluated the feasibility of using TV acetone extracts as a functional food based on experiments using cell line and obese mice. The cellular triglyceride levels and Oil red O staining of 3T3-L1 cells indicated that TV extracts (5 and 10 μg/mL) dose-dependently suppressed adipocyte differentiation and lipid accumulation compared with the control. The TV extract (0.4%, w/w) in a high-fat diet (HFD) was supplemented to C57BL/6N mice for 12 weeks, and TV extract supplement significantly reduced visceral fat mass and body weight compared with HFD feeding alone...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29332706/skin-mapping-for-the-classification-of-generalized-morphea
#13
Noelle Teske, Joseph Welser, Heidi Jacobe
BACKGROUND: Generalized morphea lacks cohesive clinical features, limiting its clinical and investigative utility. OBJECTIVE: We sought to use computerized lesion mapping to objectively subtype morphea. METHODS: We conducted a 2-part cross-sectional study. In part 1, we created a discovery cohort of patients with generalized morphea of whom lesion maps were created to characterize subsets. Clinical and demographic features were compared between proposed subsets to determine if they identified clinically relevant differences...
February 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29332390/high-drug-loading-and-sub-quantitative-loading-efficiency-of-polymeric-micelles-driven-by-donor-receptor-coordination-interactions
#14
Shixian Lv, Yuchen Wu, Kaimin Cai, Hua He, Yongjuan Li, Min Lan, Xuesi Chen, Jianjun Cheng, Lichen Yin
Polymeric micelles are extensively used for the delivery of hydrophobic drugs, which however, suffer from unsatisfactory drug loading, colloidal uniformity, formulation stability, and drug release. Herein, we demonstrate a convenient strategy to prepare micelles with ultra-high drug loading via the incorporation of polymer-drug coordination interactions. An amphiphilic copolymer containing pendant phenylboronic acid as electron acceptor unit was synthesized, which afforded donor-acceptor coordination with doxorubicin to obtain micelles with ultra-high drug loading (~50%), nearly quantitative loading efficiency (>95%), uniform size, and colloidal stability...
January 13, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29331219/polycyclic-aromatic-hydrocarbons-in-soils-and-lichen-from-the-western-tibetan-plateau-concentration-profiles-distribution-and-its-influencing-factors
#15
Ruichen Zhou, Ruiqiang Yang, Chuanyong Jing
The Tibetan Plateau (TP) is a huge area and rarely affected by human activity, and is regarded as one of the most remote regions on the earth. Many studies about the long-range atmospheric transport (LRAT) of semi-volatile organic compounds (SVOCs) were conducted in southern and central TP. However, there are very limited studies focused on PAHs in the western TP and the concentrations profiles, distribution and its controlling factors in this area remains unclear. Thus, to explore this knowledge gap, 37 surface soil samples and 23 lichen samples were collected and analyzed for PAHs...
January 10, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29330580/-lichen-ruber-planus-better-understanding-better-treatment
#16
REVIEW
L Schilling, T Vogt
Lichen ruber, also called lichen ruber planus or lichen planus (LP), is a noncontagious inflammatory skin disease. LP is the main representative and namesake of the group of lichenoid diseases, which are characterized by small papules often accompanied by severe itching. With 65% of cases, LP is primarily a disease of the mucous membranes. In 20% of the cases, the disease is found on the skin and mucous membranes; skin involvement alone is seen in only about 10% of cases. Cutaneous LP has a very favorable 1‑year prognosis of almost 80% healing as opposed to the mucosa and the adnexal organs...
January 12, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29328891/dysplasia-should-not-be-ignored-in-lichenoid-mucositis
#17
L D Rock, D M Laronde, I Lin, M P Rosin, B Chan, B Shariati, L Zhang
Oral lichen planus is categorized as a potentially malignant condition by the World Health Organization; however, some argue that only lichen planus with dysplasia have malignant potential. Many pathologists call lichen planus with dysplasia "dysplasia with lichenoid mucositis (LM)" or "LM with dysplasia." Previous research has shown that certain high-risk patterns of loss of heterozygosity (LOH) in dysplastic lesions are associated with significantly increased cancer risk. However, LM without dysplasia lacks such molecular patterns, supporting the hypothesis that LM, by itself, is not potentially malignant and that only those with dysplasia have malignant potential...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29328529/hinokitiol-ablates-myofibroblast-activation-in-precancerous-oral-submucous-fibrosis-by-targeting-snail
#18
Hui-Wen Yang, Ming-Yi Lu, Yu-Wei Chiu, Yi-Wen Liao, Yu-Feng Huang, Pin Ju Chueh, Pei-Ling Hsieh, Cheng-Chia Yu
Oral submucous fibrosis (OSF) is a precancerous condition with symptoms of limited mouth opening and areca nut chewing habit has been implicated in its pathogenesis. Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. Here, we showed that hinokitiol reduced the myofibroblast activities in fBMFs and prevented the arecoline-induced transdifferentiation. Treatment of hinokitiol dose-dependently downregulated the myofibroblast markers as well as various EMT transcriptional factors...
January 12, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29326823/lichen-planus-following-tetanus-diphtheria-acellular-pertussis-vaccination-a-case-report-and-review-of-the-literature
#19
Heather C Rosengard, Chikoti M Wheat, Matthew P Tilson, Jonathan D Cuda
Lichen planus is an inflammatory dermatosis with a prevalence of approximately 1%. Recent meta-analyses show that patients with hepatitis C virus have a 2.5- to 4.5-fold increased risk of developing lichen planus. Lichen planus has also followed vaccinations and has specifically been attributed to the hepatitis B vaccine, the influenza vaccine, and the tetanus-diphtheria-acellular pertussis vaccine. We describe a case of lichen planus in a hepatitis C virus-infected African American male occurring in temporal association with the administration of the tetanus-diphtheria-acellular pertussis vaccine...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29320633/bioaccumulation-of-polybrominated-diphenyl-ethers-pbdes-and-alternative-halogenated-flame-retardants-in-a-vegetation-caribou-wolf-food-chain-of-the-canadian-arctic
#20
Adam David Morris, Derek Muir, Keith Solomon, Camilla Teixeira, Mark Duric, Xiaowa Wang
The trophodynamics of halogenated flame retardants (HFRs) including polybrominated diphenyl ethers (PBDEs) and alternative HFRs were investigated in the terrestrial, vegetation-caribou-wolf food chain in the Bathurst Region of northern Canada. The greatest concentrations in vegetation (geometric mean of lichens, moss, grasses, willow, and mushrooms) were of the order 2,4,6-tribromophenyl allyl ether (TBP-AE) (10 ng g-1 lw) > BDE47 (5.5 ng g-1 lw) > BDE99 (3.9 ng g-1 lw) > BDE100 (0.82 ng g-1 lw) > 1,2,3,4,5-pentabromobenzene (PBBz) (0...
January 10, 2018: Environmental Science & Technology
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