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https://www.readbyqxmd.com/read/28811522/the-lichen-secondary-metabolite-atranorin-suppresses-lung-cancer-cell-motility-and-tumorigenesis
#1
Rui Zhou, Yi Yang, So-Yeon Park, Thanh Thi Nguyen, Young-Woo Seo, Kyung Hwa Lee, Jae Hyuk Lee, Kyung Keun Kim, Jae-Seoun Hur, Hangun Kim
Lichens are symbiotic organisms that produce various secondary metabolites. Here, different lichen extracts were examined to identify secondary metabolites with anti-migratory activity against human lung cancer cells. Everniastrum vexans had the most potent inhibitory activity, and atranorin was identified as an active subcomponent of this extract. Atranorin suppressed β-catenin-mediated TOPFLASH activity by inhibiting the nuclear import of β-catenin and downregulating β-catenin/LEF and c-jun/AP-1 downstream target genes such as CD44, cyclin-D1 and c-myc...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810530/caspase-dependent-and-caspase-independent-induction-of-apoptosis-in-breast-cancer-by-fucoidan-via-the-pi3k-akt-gsk3%C3%AE-pathway-in-vivo-and-in-vitro
#2
Meilan Xue, Xinqiang Ji, Chuanxing Xue, Hui Liang, Yinlin Ge, Xinjia He, Li Zhang, Kang Bian, Lichen Zhang
Purpose Fucoidan, a complex, sulfated polysaccharide obtained from brown seaweed, exerted anticancer activity through the down-regulation of β-catenin signaling in mouse breast cancer cells in our previous study. This study examines the anti-cancer effects of fucoidan as well as its underlying molecular mechanisms in the human triple negative breast cancer (TNBC) cell line and in 7,12-dimethylbenz[a]anthracene (DMBA)-induced experimental mammary carcinogenesis in rats. Methods in vitro studies, fluorescent staining, flow cytometry and Western blotting were performed to analyze apoptosis and protein expression in human breast cancer MDA-MB-231 cells...
August 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28810520/studies-on-the-regulation-of-lipid-metabolism-and-the-mechanism-of-the-aqueous-and-ethanol-extracts-of-usnea
#3
Jiali Zhu, Xuemei Zhang, Xiu Chen, Yong Sun, Yaolan Dai, Chang Chen, Tiane Zhang, Zhiyong Yan
OBJECTIVES: Usnea is a lichen of Usnea diffracta Vain and Usnea longissima Ach, which belongs to the genus Usnea Adans of Usneaceae. Usnea exerts numerous pharmacological activities, while its lipid regulatory activities remain unreported. This study aims to evaluate the effects of aqueous and ethanol extracts of Usnea on the regulation of lipid metabolism and to explore the possible mechanism. METHODS: Hyperlipidemia rat model was established by feeding with high-fat diet for 45days...
August 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28809373/scoring-systems-for-oral-lichen-planus-used-by-differently-experienced-raters
#4
M Gobbo, K Rupel, V Zoi, G Perinetti, G Ottaviani, R Di Lenarda, L Bevilacqua, S-B Woo, M Biasotto
BACKGROUND: Scoring systems have been widely used to evaluate the severity and activity of oral lichen planus (OLP). The aim of the present study was to compare two existing (one modified) scoring systems in the evaluation of OLP severity and correlation with pain. Three differently experienced raters were involved. MATERIALS AND METHODS: Consecutive patients with OLP were assessed for pain using the Visual Analogue Scale and examined at 10 intraoral sites before starting (T0) and three weeks after (T1) steroid therapy (Clobetasol)...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28809371/the-role-of-micrornas-in-oral-lichenoid-disorders-systematic-review
#5
A Setién-Olarra, M-L Gainza-Cirauqui, J-M Aguirre-Urizar, X Marichalar-Mendia
BACKGROUND: Certain changes in the microRNA expression are considered to be associated with chronic inflammatory processes and with the malignant transformation of oral potentially malignant disorders. The purpose of this systematic review is to update the existing data on the aberrant microRNA expression profiles identified in oral lichenoid disease (OLD). MATERIAL AND METHODS: A search in PubMed-Medline and Scopus was performed on the English literature published between 2010 and August 2016 using the following keywords: oral lichenoid disease, oral lichen planus and microRNA...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28807121/fractional-carbon-dioxide-laser-in-combination-with-topical-corticosteroid-an-innovative-treatment-for-hypertrophic-lichen-planus
#6
Imran Majid
No abstract text is available yet for this article.
September 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28804803/comparison-of-sample-preparation-procedures-on-metal-loid-fractionation-patterns-in-lichens
#7
E M Kroukamp, T W Godeto, P B C Forbes
The effects of different sample preparation strategies and storage on metal(loid) fractionation trends in plant material is largely underresearched. In this study, a bulk sample of lichen Parmotrema austrosinense (Zahlbr.) Hale was analysed for its total extractable metal(loid) content by ICP-MS, and was determined to be adequately homogenous (<5% RSD) for most elements. Several subsets of this sample were prepared utilising a range of sample preservation techniques and subjected to a modified sequential extraction procedure or to total metal extraction...
August 13, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28803921/molecular-evidence-of-apatococcus-including-a-fuscideae-sp-nov-as-photobiont-in-the-genus-fuscidea
#8
Martina Zahradníková, Heidi L Andersen, Tor Tønsberg, Andreas Beck
The knowledge of the taxonomy and classification of algae (including lichenized) has recently increased rapidly, but there are still many gaps. We aimed to 1) identify the Fuscidea photobionts by locating their taxonomic positions in the green algal classification, and 2) to resolve their interspecific relationships. The lichenized algae were examined based on morphological observations of axenic isolates as well as molecular studies of 18S and ITS nrDNA sequences. Analysis of the secondary structure of the ITS2 operon complemented these investigations...
June 29, 2017: Protist
https://www.readbyqxmd.com/read/28801716/-plastic-surgery-reconstruction-of-the-adult-buried-penis-option-or-obligation
#9
REVIEW
S Mühlstädt, P Anheuser, N Mohammed, A D Bach
The adult buried penis afflicts the patient with shame and is also potentially associated with considerable urogenital complications. Due to obesity, chronic urogenital lymphedema or subsequent inflammatory urogenital conditions, such as a lichen sclerosus et atrophicus, the clinical appearance of the adult buried penis is extremely variable. Epidemiological data are non-existent. Therapeutically, a combination of various plastic surgery procedures is often necessary for the best esthetic and functional results...
August 11, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28801011/paraneoplastic-pemphigus-a-life-threatening-autoimmune-blistering-disease
#10
A Tirado-Sánchez, A Bonifaz
Paraneoplastic pemphigus (PNP), a subset of pemphigus, is a unique autoimmune blistering condition that can affect multiple organs other than the skin. It is a life-threatening disease associated with an underlying malignancy, most commonly of lymphoproliferative origin. The clinical picture may resemble pemphigus, pemphigoid, erythema multiforme, graft-versus-host disease, or lichen planus. The earliest and most consistent finding is a painful, severe, chronic and often recalcitrant stomatitis. Treatment of PNP is difficult...
August 8, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28800445/enzyme-sensitive-gemcitabine-conjugated-albumin-nanoparticles-as-a-versatile-theranostic-nanoplatform-for-pancreatic-cancer-treatment
#11
Haijie Han, Jinhui Wang, Tingting Chen, Lichen Yin, Qiao Jin, Jian Ji
Development of gemcitabine (GEM) nanocarriers as theranostic agents for pancreatic cancer chemotherapy has received extensive attention in recent years. A novel enzyme-sensitive albumin-based GEM delivery nanoplatform was developed in this research by simple conjugation of GEM to human serum albumin (HSA) via cathepsin B cleavable peptide GFLG and then complexing with near-infrared (NIR) dye IR780, forming a HSA-GEM/IR780 complex. The successful preparation of HSA-GEM/IR780 complex was confirmed by Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS), UV-vis-NIR absorption spectra and fluorescent emission spectra...
July 17, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28796915/clearance-in-vulvar-lichen-sclerosus-a-realistic-treatment-endpoint-or-a-chimera
#12
A Borghi, A Virgili, S Minghetti, G Toni, M Corazza
BACKGROUND: according to the current guidelines, the aim of vulvar lichen sclerosus (VLS) treatment is to improve symptoms and signs, not to cure. OBJECTIVE: to assess i) the rate of VLS patients who achieved complete clearance of symptoms or objective features, or both, with a 12-week pharmacological treatment and ii) the predictive value of therapeutic response of the demographic and clinical features. METHODS: we retrospectively included VLS patients who had undergone any topical treatment for 12 weeks; demographics, history, VLS-related symptoms and objective features recorded at baseline and on completion of treatment were collected and elaborated...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28795241/papillomavirus-genotyping-on-formaldehyde-fixed-paraffin-embedded-tissues-in-vulvar-intraepithelial-neoplasia
#13
S Mazellier, B Dadone-Montaudie, A Chevallier, C Loubatier, S Vitale, N Cardot-Leccia, K Angeli, C Trastour, J Delotte, V Giordanengo, D Ambrosetti
PURPOSE: Few studies have described the epidemiology of human papillomavirus (HPV) in vulvar intraepithelial neoplasia (VIN). The aim of this study was to genotype HPV on formalin fixed paraffin-embedded tissues in VIN lesions. METHODS: A 5-year retrospective study was conducted by including all patients attending the teaching hospital of Nice with a diagnosis of VIN between 1st January 2010 and 31st December 2014. For all patients, HPV genotyping was performed with the PapilloCheck(®) microarray kit, routinely used on cervical cytology samples, and optimized for formaldehyde fixed paraffin-embedded tissues in VIN...
August 9, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28794568/severely-crusted-cheilitis-as-an-initial-presentation-of-systemic-lupus-erythematosus
#14
Wai Man Mandy Chan, Shiu Ming Pang, See Ket Ng
Lupus erythematosus (LE) is an autoimmune disease which may initially present solely with lip lesions. Due to a wide spectrum of presentation, these features may initially be misdiagnosed as other oral diseases such as lichen planus, erythema multiforme (EM), and actinic cheilitis, leading to a delay in diagnosis and treatment. We discuss a case of severely crusted cheilitis which was initially diagnosed as EM, with subsequent development of subacute cutaneous LE, and progression to systemic LE. We will discuss the clinical and histological features of lupus cheilitis...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28793884/therapeutic-comparison-between-treatments-for-vulvar-lichen-sclerosus-study-protocol-of-a-randomized-prospective-and-controlled-trial
#15
Renata A Belotto, Maria Cristina Chavantes, João Paulo Tardivo, Roberto Euzébio Dos Santos, Raquel Civolani Marques Fernandes, Anna Carolina Ratto Tempestini Horliana, Christiane Pavani, Daniela Fátima Teixeira da Silva
BACKGROUND: Vulvar lichen sclerosus (VLS) is a lymphocyte-mediated disease of unknown etiology that can cause intense itching as well stenosis, hindering the evacuation and urination. It can also limit the sex life due to severe local pruritus, pain and dyspareunia (pain during sexual intercourse). The standard treatment for this disease is the use of topical corticosteroids to reduce the clinical symptoms and to try to increase disease-free intervals. Photodynamic therapy (PDT), a treatment that associates a light radiation with a photosensitizing agent and photobiomodulation (PBM) are therapies that can promote effective immunomodulatory responses at the application site by means of photophysical and photochemical phenomena from the molecular to the systemic level, which promote their use in chronic dermatoses...
August 10, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28791692/skin-diseases-in-indigenous-population-retrospective-epidemiological-study-at-xingu-indigenous-park-xip-and-review-of-the-literature
#16
Jenifer S A Wu, Marcos C Florian, Douglas A Rodrigues, Jane Tomimori
BACKGROUND: Skin diseases among indigenous populations have been poorly described in the literature. Risk factors linked to habits, cultural practices, genetics, and environmental characteristics can influence the frequency and clinical presentation of these diseases. METHODS: This was a cross-sectional study conducted through a review of dermatological medical records. Data were obtained over three visits to Xingu Indigenous Park (XIP). Main dermatoses were compared by gender, age, ethnicity, and village...
August 9, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28791421/erratum-to-autoantibodies-to-desmogleins-1-and-3-in-patients-with-lichen-planus
#17
Vahide Lajevardi, Zahra Halaji, Forugh Ghaedi, Nazi Saljoughi
No abstract text is available yet for this article.
August 8, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28789612/lichenoid-esophagitis-presenting-as-fatal-upper-gastrointestinal-bleeding-in-a-52%C3%A2-year-old-woman-a-case-diagnosed-by-autopsy
#18
Andrew Mitchell, Tony Petrella
BACKGROUND: "Lichenoid esophagitis" is a descriptive term for a lichenoid pattern of inflammation in the esophagus for which a precise histologic diagnosis cannot be established. The differential diagnosis includes lichen planus, a drug-related reaction, and viral infection. Lichenoid esophagitis causing death has not been reported previously. We describe a case, diagnosed by autopsy, of lichenoid esophagitis in which massive bleeding from generalized epithelial sloughing and a large longitudinal ulcer proved fatal...
August 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28782804/discovery-of-long-distance-gamete-dispersal-in-a-lichen-forming-ascomycete
#19
Cecilia Ronnås, Silke Werth, Otso Ovaskainen, Gergely Várkonyi, Christoph Scheidegger, Tord Snäll
Accurate estimates of gamete and offspring dispersal range are required for the understanding and prediction of spatial population dynamics and species persistence. Little is known about gamete dispersal in fungi, especially in lichen-forming ascomycetes. Here, we estimate the dispersal functions of clonal propagules, gametes and ascospores of the epiphytic lichen Lobaria pulmonaria. We use hierarchical Bayesian parentage analysis, which integrates genetic and ecological information from multiannual colonization and dispersal source data collected in a large, old-growth forest landscape...
August 7, 2017: New Phytologist
https://www.readbyqxmd.com/read/28782194/the-preparation-of-hyaluronic-acid-nanoparticles-from-aspicilia-lichens-using-bifido-bacteria-for-help-in-the-treatment-of-diabetes-in-rats-in-vivo
#20
Akbar Esmaeili, Shirin Rajaee
Many common herbs and spices are claimed to have blood sugar lowering properties that make them useful for people with or at high risk of diabetes. The main of compounds of kiwifruit (Actinidia deliciosa), rhubarb (Rheum ribes), membrane inner of egg shell, wool of sheep, human fingernail (unguis), hyaluronic acid produced by the Bifidobacterium, and usnic acid of Aspicilia lichen were extracted by different methods. All compounds of the extract were divided into five groups. We used variables such as pH, different compounds, concentration, number of injections, and blood glucose monitoring in different situations...
August 7, 2017: Phytotherapy Research: PTR
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