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https://www.readbyqxmd.com/read/28526592/photodynamic-therapy-in-the-treatment-of-vulvar-lichen-sclerosus
#1
Agnieszka Maździarz, Beata Osuch, Magdalena Kowalska, Agnieszka Nalewczyńska, Beata Śpiewankiewicz
BACKGROUND: Vulvar lichen sclerosus is a chronic and incurable disease that causes various unpleasant symptoms and serious consequences. OBJECTIVE: The purpose of the study was to assess the effectiveness of photodynamic therapy in the treatment of vulvar lichen sclerosus. METHODS: Participants in the study included 102 female patients aged 19-85 suffer from vulvar lichen sclerosus. The patients underwent photodynamic therapy (PDT). In the course of PDT the 5% 5- aminolevulinic acid was used in gel form...
May 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28524063/association-between-hcv-infection-and-cutaneous-mucosal-lichen-planus-an-update
#2
Sara Pinelli, Stefano Basile, Pierluigi Benedetti Panici, Angelo Massimiliano D'Erme, Marco Romanelli, Francesco Plotti, Maria Giovanna Salerno
No abstract text is available yet for this article.
May 19, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28523261/rejuvenation-using-platelet-rich-plasma-and-lipofilling-for-vaginal-atrophy-and-lichen-sclerosus
#3
Seok Hwan Kim, Eun Soo Park, Tae Hee Kim
Vaginal atrophy is a common condition among peri- and post-menopausal women. Symptoms of vaginal dryness, pruritus, irritation, loss of subcutaneous fat, sparse pubic hair and dyspareunia occur due to decreased estrogen level. Estrogen-based treatments are effective. But many patients are reluctant to be treated due to health concerns. As alternatives, we explored the efficacy of platelet-rich plasma (PRP) and lipofilling. A 67-year-old female patient with vaginal atrophy was referred to our department. Treatment using estrogen cream had failed to improve patient's symptoms...
April 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28522404/tubo-ovarian-abscess-in-a-virginal-adolescent-with-labial-agglutination-due-to-lichen-sclerosus
#4
Bianca Stortini, Ozlem Dural, Maria Kielly, Nathalie Fleming
BACKGROUND: We describe an unusual presentation of lichen sclerosus in a postmenarchal, virginal girl. CASE: A 14 year-old girl first presented with acute urinary retention due to labial agglutination and developed bilateral tubo-ovarian abscesses in 10 days of the conservative management period. Abscesses were treated with antibiotherapy and percutaneous drainage; simple division of the labial agglutination and vulvar biopsies were performed with a preliminary diagnosis of lichen sclerosus...
May 15, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28522040/the-depth-of-inflammation-in-frontal-fibrosing-alopecia-and-lichen-planopilaris-a-potential-distinguishing-feature
#5
Denise Wong, Lynne J Goldberg
No abstract text is available yet for this article.
June 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28515896/a-worldwide-phylogeography-of-the-whiteworm-lichens-thamnolia-reveals-three-lineages-with-distinct-habitats-and-evolutionary-histories
#6
Ioana Onuţ-Brännström, Leif Tibell, Hanna Johannesson
Thamnolia is a lichenized fungus with an extremely wide distribution, being encountered in arctic and alpine environments in most continents. In this study, we used molecular markers to investigate the population structure of the fungal symbiont and the associated photosynthetic partner of Thamnolia. By analyzing molecular, morphological, and chemical variation among 253 specimens covering the species distribution range, we revealed the existence of three mycobiont lineages. One lineage (Lineage A) is confined to the tundra region of Siberia and the Aleutian Islands, a second (Lineage B) is found in the high alpine region of the Alps and the Carpathians Mountains, and a third (Lineage C) has a worldwide distribution and covers both the aforementioned ecosystems...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28515022/sos-response-in-bacteria-inhibitory-activity-of-lichen-secondary-metabolites-against-escherichia-coli-reca-protein
#7
Pierangelo Bellio, Letizia Di Pietro, Alisia Mancini, Marisa Piovano, Marcello Nicoletti, Fabrizia Brisdelli, Donatella Tondi, Laura Cendron, Nicola Franceschini, Gianfranco Amicosante, Mariagrazia Perilli, Giuseppe Celenza
BACKGROUND: RecA is a bacterial multifunctional protein essential to genetic recombination, error-prone replicative bypass of DNA damages and regulation of SOS response. The activation of bacterial SOS response is directly related to the development of intrinsic and/or acquired resistance to antimicrobials. Although recent studies directed towards RecA inactivation via ATP binding inhibition described a variety of micromolar affinity ligands, inhibitors of the DNA binding site are still unknown...
June 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28513659/serum-resistant-reactive-oxygen-species-ros-potentiated-gene-delivery-in-cancer-cells-mediated-by-fluorinated-diselenide-crosslinked-polyplexes
#8
Qiurong Deng, Xudong Li, Lipeng Zhu, Hua He, Donglai Chen, Yongbing Chen, Lichen Yin
The transfection performance of polycations is often hampered by various systemic barriers that pose conflicting requirements for material design. Herein, we developed fluorinated, ROS-cleavable polyethylenimine (PEI) for effective and serum-resistant gene delivery to cancer cells, by harmonizing the inconsistency between DNA condensation and release, and the inconsistency between cellular internalization and serum stability. Low-molecular weight (MW) PEI was cross-linked with a diselenide-containing linker and further modified with fluorocarbon chains...
May 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28513562/effects-of-growth-media-on-the-diversity-of-culturable-fungi-from-lichens
#9
Lucia Muggia, Theodora Kopun, Martin Grube
Microscopic and molecular studies suggest that lichen symbioses contain a plethora of associated fungi. These are potential producers of novel bioactive compounds, but strains isolated on standard media usually represent only a minor subset of these fungi. By using various in vitro growth conditions we are able to modulate and extend the fraction of culturable lichen-associated fungi. We observed that the presence of iron, glucose, magnesium and potassium in growth media is essential for the successful isolation of members from different taxonomic groups...
May 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28512746/a-panel-of-micrornas-can-be-used-to-determine-oral-squamous-cell-carcinoma
#10
Gareema Prasad, Christine Seers, Eric Reynolds, Michael J McCullough
BACKGROUND: Subjective histopathology is currently used to diagnose oral squamous cell carcinoma (OSCC). We tested if abundances of a panel of microRNA could be an objective OSCC indicator. METHOD: Literature review enabled identification of 10 microRNAs associated with oral and head and neck malignancies. We extracted RNA from formalin-fixed paraffin embedded biopsies; 20 each with OSCC, dysplasia or histologically normal epithelium (HNE) and 10 with oral lichen planus (OLP)...
May 17, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28511823/dissociation-and-conversion-symptoms-in-dermatology
#11
Madhulika A Gupta, Branka Vujcic, Aditya K Gupta
Dissociation and conversion (defined as the somatic component of dissociation) can play an important mediating role in the exacerbation of the stress-reactive dermatoses (eg, psoriasis, idiopathic urticaria, atopic dermatitis), dermatoses that are exacerbated by excessive scratching (eg, lichen simplex chronicus, prurigo nodularis) and koebnerization, and the self-induced dermatoses (dermatitis artefacta, acne excoriée, skin picking disorder, trichotillomania, onychotillomania/onychophagia). Dissociative symptoms often coexist with obsessive-compulsive symptoms in the more severe cases of the self-induced dermatoses...
May 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28510551/the-meaning-of-lichen
#12
Erica Gies
No abstract text is available yet for this article.
May 16, 2017: Scientific American
https://www.readbyqxmd.com/read/28510445/establishment-of-a-direct-injection-electron-ionization-mass-spectrometry-metabolomics-method-and-its-application-to-lichen-profiling
#13
Hisahiro Kai, Kaoru Kinoshita, Hiroshi Harada, Yoshihiro Uesawa, Akihiro Maeda, Ryuichiro Suzuki, Yoshihito Okada, Kunio Takahashi, Koji Matsuno
Direct-injection electron-ionization-mass spectrometry (DI-EI-MS) is a multivariate analysis method useful for characterizing biological materials. We demonstrated the use of DI-EI-MS for metabolic profiling using several closely related lichen species: Cladonia krempelhuberi, C. gracilis, C. pseudogymnopoda, and C. ramulosa. The methodology involves conversion of total ion chromatograms to integrated chromatograms and assessment of reproducibility. The qualitative DI-EI-MS method was used to profile the major and/or minor constituents in extracts of lichen samples...
May 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28509898/modern-pollen-data-from-the-canadian-arctic-1972-1973
#14
Harvey Nichols, Susann Stolze
This data descriptor reports results of a 1972-73 baseline study of modern pollen deposition in the Canadian Arctic to originally aid interpretation of Holocene pollen diagrams from that region, especially focussed on the arctic tree-line. The data set is geographically unique due to its extent, and allows the assessment of the effects of modern climate change on northern ecosystems, including fluctuations of the a arctic tree-line. Repeated sampling was conducted along an interior transect at 29 sites from the Boreal Forest to the High Arctic, with five additional coastal sites covering a total distance of 3,200 km...
May 16, 2017: Scientific Data
https://www.readbyqxmd.com/read/28509523/skin-diseases-and-tattoos-a-five-year-experience
#15
Maddalena Napolitano, Matteo Megna, Milena Cappello, Caterina Mazzella, Cataldo Patruno
BACKGROUND: Decorative tattooing as a body art form underwent an exponential increase during the last two decades, particularly among teenagers and young adults. Consequently, the number of reported adverse reactions after tattooing has increased. The most frequent reported skin reactions to tattoo include infectious (bacterial, viral, fungal) or inflammatory (allergic contact dermatitis and granulomatous reaction) diseases. Moreover, tattoos can also induce the development of typical skin lesions of pre-existing dermatoses, a phenomenon known as isomorphism reactive or Koëbner phenomenon, which commonly occurs in patients with psoriasis, vitiligo, or lichen planus...
May 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28506683/the-caspase-1-inhibitor-card18-is-specifically-expressed-during-late-differentiation-of-keratinocytes-and-its-expression-is-lost-in-lichen-planus
#16
Haihong Qin, Jiang Jin, Heinz Fischer, Michael Mildner, Maria Gschwandtner, Veronika Mlitz, Leopold Eckhart, Erwin Tschachler
BACKGROUND: CARD18 contains a caspase recruitment domain (CARD) via which it binds to caspase-1 and thereby inhibits caspase-1-mediated activation of the pro-inflammatory cytokine interleukin (IL)-1β. OBJECTIVES: To determine the expression profile and the role of CARD18 during differentiation of keratinocytes and to compare the expression of CARD18 in normal skin and in inflammatory skin diseases. METHODS: Human keratinocytes were induced to differentiate in monolayer and in 3D skin equivalent cultures...
May 1, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28502067/predictive-value-of-salivary-microrna-320a-vascular-endothelial-growth-factor-receptor-2-crp-and-il-6-in-oral-lichen-planus-progression
#17
Minoo Shahidi, Soudeh Jafari, Mahmood Barati, Masoumeh Mahdipour, Mohammad Saeed Gholami
INTRODUCTION: MicroRNA (miRNA) 320a and vascular endothelial growth factor receptor 2 (VEGFR-2) expression as the angiogenic biomarkers might be therapeutic targets in Oral lichen planus (OLP). IL-6 and C-reactive protein (CRP) could be prognostic in OLP, dysplastic OLP and Oral squamous cell carcinoma (OSCC). Therefore, their salivary detections as the noninvasive tools were aimed in this study. MATERIALS AND METHODS: Histopathologic examinations were carried out to distinguish the patients with dysplastic OLP and OSCC...
May 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28499235/probiotics-a-non-conventional-therapy-for-oral-lichen-planus
#18
REVIEW
Xiao Han, Jing Zhang, Yaqin Tan, Gang Zhou
Oral lichen planus (OLP) is a common T-cell mediated chronic inflammatory disease. Although the etiology is still unclear, present studies suggest that the composition of the oral microbiota and psychological problems are implicated in the etiology of OLP. The pathogenesis of OLP includes mainly antigen-specific and non-specific mechanisms. Antigen-specific mechanisms involve T-cell activation following antigen presentation and apoptosis of basal keratinocytes triggered by CD8(+) cytotoxic T cells, while non-specific mechanisms consist of matrix metalloproteinase over-expression and mast cell degranulation in OLP lesions...
April 26, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28494213/tumor-like-microenvironment-in-oral-lichen-planus-evidence-of-malignant-transformation
#19
Qiao Peng, Jing Zhang, Xiaojing Ye, Gang Zhou
Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory autoimmune disease affecting 0.1% to 4% of the world population. The WHO has already recognized it as an oral potentially malignant disorder. However, the reasons for the malignant transformation of OLP are far from being elucidated clearly. The purpose of this review is to clarify how the tumor-like microenvironment in OLP mediates its potentially malignant transformation. Areas covered: We review published articles on the microenvironment characteristics of tumors, the pathogenesis of OLP, and clinical studies of OLP...
June 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28492056/lichenoid-vulvar-disease-a-review
#20
REVIEW
R Fruchter, L Melnick, M K Pomeranz
Vulvar dermatoses are common, potentially debilitating conditions that can be seen by a variety of medical specialists. Lichenoid vulvar diseases, namely lichen sclerosus (LS), lichen planus (LP), and lichen simplex chronicus (LSC), can all negatively impact patients' quality of life and LS and LP also have an association with squamous cell carcinoma. It is essential that dermatologists are familiar with the unique features of each of these conditions to ensure the appropriate management and follow up. Herein, we provide an update on the epidemiology, clinical presentation, histopathology, and treatment of patients with vulvar LS, LP, and LSC...
March 2017: International Journal of Women's Dermatology
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