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https://www.readbyqxmd.com/read/28636649/factors-associated-with-successful-transition-among-children-with-disabilities-in-eight-european-countries
#1
John Ravenscroft, Kerri Wazny, John M Davis
INTRODUCTION: This research paper aims to assess factors reported by parents associated with the successful transition of children with complex additional support requirements that have undergone a transition between school environments from 8 European Union member states. METHODS: Quantitative data were collected from 306 parents within education systems from 8 EU member states (Bulgaria, Cyprus, Greece, Ireland, the Netherlands, Romania, Spain and the UK). The data were derived from an online questionnaire and consisted of 41 questions...
2017: PloS One
https://www.readbyqxmd.com/read/28631261/distinct-post-translational-features-of-type-i-collagen-are-conserved-in-mouse-and-human-periodontal-ligament
#2
D M Hudson, M Garibov, D R Dixon, T Popowics, D R Eyre
BACKGROUND AND OBJECTIVE: Specifics of the biochemical pathways that modulate collagen cross-links in the periodontal ligament (PDL) are not fully defined. Better knowledge of the collagen post-translational modifications that give PDL its distinct tissue properties is needed to understand the pathogenic mechanisms of human PDL destruction in periodontal disease. In this study, the post-translational phenotypes of human and mouse PDL type I collagen were surveyed using mass spectrometry...
June 20, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28630328/toll-like-receptor-pathway-evolution-in-deuterostomes
#3
Michael G Tassia, Nathan V Whelan, Kenneth M Halanych
Animals have evolved an array of pattern-recognition receptor families essential for recognizing conserved molecular motifs characteristic of pathogenic microbes. One such family is the Toll-like receptors (TLRs). On pathogen binding, TLRs initiate specialized cytokine signaling catered to the class of invading pathogen. This signaling is pivotal for activating adaptive immunity in vertebrates, suggesting a close evolutionary relationship between innate and adaptive immune systems. Despite significant advances toward understanding TLR-facilitated immunity in vertebrates, knowledge of TLR pathway evolution in other deuterostomes is limited...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28623838/economic-analysis-of-an-epilepsy-outreach-model-of-care-in-a-university-hospital-setting
#4
Eimer Maloney, Ronan N McGinty, Daniel J Costello
The prevalence of epilepsy in people with intellectual disability is higher than in the general population and prevalence rates increase with increasing levels of disability. Prevalence rates of epilepsy are highest among those living in residential care. The healthcare needs of people with intellectual disability and epilepsy are complex and deserve special consideration in terms of healthcare provision and access to specialist epilepsy clinics, which are usually held in acute hospital campuses. This patient population is at risk of suboptimal care because of significant difficulties accessing specialist epilepsy care which is typically delivered in the environs of acute hospitals...
June 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28616347/intraoperative-care-for-aortic-surgery-using-circulatory-arrest
#5
REVIEW
Félix Ezequiel Fernández Suárez, David Fernández Del Valle, Adrián González Alvarez, Blanca Pérez-Lozano
The total circulatory arrest (CA) is necessary to achieve optimal surgical conditions in certain aortic pathologies, especially in those affecting the ascending aorta and aortic arch. During this procedure it is necessary to protect all the organs of ischemia, especially those of the central nervous system and for this purpose several strategies have been developed. The first and most important protective method is systemic hypothermia. The degree of hypothermia and the route of application have been evolving and currently tend to use moderate hypothermia (MH) (20...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28614451/-indigenous-peoples-access-to-health-services-in-cuiab%C3%A3-mato-grosso-state-brazil
#6
Silvana Cardoso Gomes, Monique Azevedo Esperidião
This study aimed to evaluate indigenous peoples' access to medium and high-complexity health services in the municipality of Cuiabá, Mato Grosso State, Brazil, through the Casa de Saúde Indígena or Indigenous Peoples' Clinic (CASAI Cuiabá). A single case study with a qualitative approach was conducted at CASAI Cuiabá. Data were obtained from observation of the work routines at CASAI Cuiabá, semi-structured interviews with health professionals and administrators from the Cuiabá Special Indigenous Health District (DSEI) and CASAI Cuiabá, and document analysis...
June 12, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28610649/enhancing-resiliency-for-elderly-populations-shelter-in-place-planning-and-training-at-facilities-serving-elderly-populations-through-the-rhode-island-senior-resiliency-project
#7
Richard Smith, Michael Mozzer, Joseph Albanese, James Paturas, Julia Gold
Elderly populations are disproportionately affected by disasters. In part, this is true because for many older adults, special assistance is needed to mitigate the consequences of disasters on their health and wellbeing. In addition, many older adults may reside in diverse living complexes such as long-term care facilities, assisted living facilities and independent-living senior housing complexes. Planning for each type of facility is different and the unique features of these facilities must be considered to develop readiness to deal with disasters...
June 1, 2017: Journal of Business Continuity & Emergency Planning
https://www.readbyqxmd.com/read/28607676/evaluating-the-quality-improvement-impact-of-the-global-tracheostomy-collaborative-in-four-diverse-nhs-hospitals
#8
Brendan A McGrath, James Lynch, Barbarella Bonvento, Sarah Wallace, Val Poole, Ann Farrell, Cristina Diaz, Sadie Khwaja, David W Roberson
Tracheostomies are predominantly used in Head & Neck Surgery and the critically ill. The needs of these complex patients frequently cross traditional speciality working boundaries and locations and any resulting airway problems can rapidly lead to significant harm. The Global Tracheostomy Collaborative (GTC) was formed in 2012 with the aim of bringing together international expertise in tracheostomy care in order to bring about rapid adoption of best practices and to improve the quality and safety of care to this vulnerable group...
2017: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/28605319/medicinal-mushrooms-in-human-clinical-studies-part-i-anticancer-oncoimmunological-and-immunomodulatory-activities-a-review
#9
Solomon P Wasser
More than 130 medicinal functions are thought to be produced by medicinal mushrooms (MMs) and fungi, including antitumor, immunomodulating, antioxidant, radical scavenging, cardiovascular, antihypercholesterolemic, antiviral, antibacterial, antiparasitic, antifungal, detoxification, hepatoprotective, antidiabetic, and other effects. Many, if not all, higher Basidiomycetes mushrooms contain biologically active compounds in fruit bodies, cultured mycelia, and cultured broth. Special attention has been paid to mushroom polysaccharides...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28594691/multidisciplinary-clinics
#10
Li Villard, Elisabeth Nordmark-Andersson, Brid Crowley, Volker Straub, Marta Bertoli
More than 400 acquired and genetic diseases are labeled as arthrogryposis. Because of their rarity and complexity coordinated patient management is often lacking. Multidisciplinary clinics are the ideal setting to provide coordinated and comprehensive care to patients with special needs. Two similar experiences of multidisciplinary clinics for the care of patients with arthrogryposis were reported at the Symposium on Arthrogryposis held in Saint Petersburg in September 2014. These clinics are organized to bring together professionals from several disciplines, with the aim to provide patient-centered, comprehensive clinical care, and reduce the burden of multiple medical appointments for the families...
July 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28593892/neonatal-hypoglycemia-risk-factors-and-outcomes
#11
Orhideja Stomnaroska, Elizabeta Petkovska, Snezana Jancevska, Dragan Danilovski
BACKGROUND AND AIMS: Severe neonatal hypoglycemia (HG) leads to neurologic damage, mental retardation, epilepsy, personality disorders, impaired cardiac performance and muscle weakness. We aimed to assess the clinical characteristics of children with hypoglycemia in a random population of newborns. PATIENTS, METHODS AND RESULTS: We investigated 84 patients (M:F=35:48) born at the University Clinic for Gynecology and Obstetrics in Skopje (hospitalized in the NICU) who were found to have hypoglycemia...
March 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28593021/tissue-and-condition-specific-isoforms-of-mammalian-cytochrome-c-oxidase-subunits-from-function-to-human-disease
#12
REVIEW
Christopher A Sinkler, Hasini Kalpage, Joseph Shay, Icksoo Lee, Moh H Malek, Lawrence I Grossman, Maik Hüttemann
Cytochrome c oxidase (COX) is the terminal enzyme of the electron transport chain and catalyzes the transfer of electrons from cytochrome c to oxygen. COX consists of 14 subunits, three and eleven encoded, respectively, by the mitochondrial and nuclear DNA. Tissue- and condition-specific isoforms have only been reported for COX but not for the other oxidative phosphorylation complexes, suggesting a fundamental requirement to fine-tune and regulate the essentially irreversible reaction catalyzed by COX. This article briefly discusses the assembly of COX in mammals and then reviews the functions of the six nuclear-encoded COX subunits that are expressed as isoforms in specialized tissues including those of the liver, heart and skeletal muscle, lung, and testes: COX IV-1, COX IV-2, NDUFA4, NDUFA4L2, COX VIaL, COX VIaH, COX VIb-1, COX VIb-2, COX VIIaH, COX VIIaL, COX VIIaR, COX VIIIH/L, and COX VIII-3...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28592275/ncbo-ontology-recommender-2-0-an-enhanced-approach-for-biomedical-ontology-recommendation
#13
Marcos Martínez-Romero, Clement Jonquet, Martin J O'Connor, John Graybeal, Alejandro Pazos, Mark A Musen
BACKGROUND: Ontologies and controlled terminologies have become increasingly important in biomedical research. Researchers use ontologies to annotate their data with ontology terms, enabling better data integration and interoperability across disparate datasets. However, the number, variety and complexity of current biomedical ontologies make it cumbersome for researchers to determine which ones to reuse for their specific needs. To overcome this problem, in 2010 the National Center for Biomedical Ontology (NCBO) released the Ontology Recommender, which is a service that receives a biomedical text corpus or a list of keywords and suggests ontologies appropriate for referencing the indicated terms...
June 7, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28584874/cluster-randomized-studies-in-educational-research-principles-and-methodological-aspects
#14
Jens Dreyhaupt, Benjamin Mayer, Oliver Keis, Wolfgang Öchsner, Rainer Muche
An increasing number of studies are being performed in educational research to evaluate new teaching methods and approaches. These studies could be performed more efficiently and deliver more convincing results if they more strictly applied and complied with recognized standards of scientific studies. Such an approach could substantially increase the quality in particular of prospective, two-arm (intervention) studies that aim to compare two different teaching methods. A key standard in such studies is randomization, which can minimize systematic bias in study findings; such bias may result if the two study arms are not structurally equivalent...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28583216/the-role-of-rare-innate-immune-cells-in-type-2-immune-activation-against-parasitic-helminths
#15
Lauren M Webb, Elia D Tait Wojno
The complexity of helminth macroparasites is reflected in the intricate network of host cell types that participate in the Type 2 immune response needed to battle these organisms. In this context, adaptive T helper 2 cells and the Type 2 cytokines interleukin (IL)-4, IL-5, IL-9 and IL-13 have been the focus of research for years, but recent work has demonstrated that the innate immune system plays an essential role. Some innate immune cells that promote Type 2 immunity are relatively abundant, such as macrophages and eosinophils...
June 6, 2017: Parasitology
https://www.readbyqxmd.com/read/28579792/amyotrophic-lateral-sclerosis-improving-care-with-a-multidisciplinary-approach
#16
REVIEW
Anne Hogden, Geraldine Foley, Robert D Henderson, Natalie James, Samar M Aoun
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, leading to death within an average of 2-3 years. A cure is yet to be found, and a single disease-modifying treatment has had a modest effect in slowing disease progression. Specialized multidisciplinary ALS care has been shown to extend survival and improve patients' quality of life, by providing coordinated interprofessional care that seeks to address the complex needs of this patient group. This review examines the nature of specialized multidisciplinary care in ALS and draws on a broad range of evidence that has shaped current practice...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28574141/totally-implantable-venous-access-devices-in-children-with-medical-complexity-preliminary-data-from-a-tertiary-care-hospital
#17
Caterina Geremia, Maria Antonietta De Ioris, Alessandro Crocoli, Ottavio Adorisio, Raffaella Scrocca, Mary Haywood Lombardi, Susanna Staccioli, Pietro Stella, Paola Amendola, Gaetano Ciliento, Francesco De Peppo, Andrea Campana
INTRODUCTION: Children with special health-care needs are an emerging and consistent population. In a subset of children with medical complexity (CMC) a continuous access to the central vascular system is advisable to eliminate unnecessary pain and stress and to improve home management and palliative care. METHODS: The surgical registry of a tertiary hospital was checked in order to identify CMC who underwent totally implantable venous access device (VAD) placement...
May 24, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28571012/challenges-in-modern-anti-doping-analytical-science
#18
Christiane Ayotte, John Miller, Mario Thevis
The challenges facing modern anti-doping analytical science are increasingly complex given the expansion of target drug substances, as the pharmaceutical industry introduces more novel therapeutic compounds and the internet offers designer drugs to improve performance. The technical challenges are manifold, including, for example, the need for advanced instrumentation for greater speed of analyses and increased sensitivity, specific techniques capable of distinguishing between endogenous and exogenous metabolites, or biological assays for the detection of peptide hormones or their markers, all of which require an important investment from the laboratories and recruitment of highly specialized scientific personnel...
2017: Medicine and Sport Science
https://www.readbyqxmd.com/read/28570215/a-comparison-of-revisional-and-primary-bariatric-surgery
#19
Courtney Fulton, Caroline Sheppard, Daniel Birch, Shazeer Karmali, Christopher de Gara
BACKGROUND: Revisional surgery is an important component of addressing weight regain and complications following primary bariatric surgery. Owing to provincial need and the complexity of this patient population, a specialized multidisciplinary revision clinic was developed. We sought to characterize patients who undergo revision surgery and compare their outcomes with primary bariatric surgery clinic data. METHODS: We completed a retrospective chart review of bariatric revision clinic patients compared with primary bariatric surgery patients from December 2009 to June 2014...
June 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28567167/nurse-competence-on-physiologic-monitors-use-toward-eliminating-alarm-fatigue-in-intensive-care-units
#20
Azizeh K Sowan, Ana G Vera, Elma I Fonseca, Charles C Reed, Albert F Tarriela, Andrea E Berndt
BACKGROUND: Studies on nurse competence on alarm management are a few and tend to be focused on limited skills. In response to Phase II of implementing the National Patient Safety Goal on clinical alarm systems safety, this study assessed nurses' perceived competence on physiologic monitors use in intensive care units (ICUs) and developed and validated a tool for this purpose. METHODS: This descriptive study took place in a Magnet hospital in a Southwestern state of the U...
2017: Open Medical Informatics Journal
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