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https://www.readbyqxmd.com/read/29148423/non-invasive-vascular-biomarkers-in-patients-with-beh%C3%A3-et-s-disease-review-of-the-data-and-future-perspectives
#1
REVIEW
Athanase D Protogerou, Efthimia G Nasothimiou, Petros P Sfikakis, Athanasios G Tzioufas
Vascular inflammation in small to large veins and arteries contributes substantially to mortality above that of the general population in Behçet's disease. Recent data verified also the presence of accelerated classical subclinical arterial damage (atheromatosis, arteriosclerosis, arterial hypertrophy) even in patients free of overt vascular complications, and may be complementary to that of vasculitis. Early detection of such vascular damage might provide helpful pathophysiological insight and potentially even guide treatment management...
October 6, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29148267/detection-of-teschovirus-type-13-from-two-swine-herds-exhibiting-nervous-clinical-signs-in-growing-pigs
#2
J Carnero, C Prieto, L Polledo, F J Martínez-Lobo
Recently, the number of clinical reports of growing pigs showing neurological signs possibly related to viral infections has increased. The objective of this report was to describe two outbreaks of an atypical condition observed in 6- to 7-week-old pigs with a morbidity of 20% and a fatality rate of 60% in two unrelated farms of the same company. During the acute phase of the disease, fever, sudden death, neurological signs, ear necrosis and occasional corneal opacity were observed. Histopathological examination revealed interstitial pneumonia, lymphoid depletion and lymphocytic vasculitis in different organs and mild polioencephalomyelitis suggesting a potential viral infection...
November 16, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29147596/carotidynia-a-rare-diagnosis-for-unilateral-neck-pain-revealed-by-cross-sectional-imaging
#3
Corrado Santarosa, Salvatore Stefanelli, Roman Sztajzel, Pravin Mundada, Minerva Becker
Idiopathic carotidynia (IC) is a rare and poorly understood syndrome consisting of unilateral neck pain, tenderness, and increased pulsations over the affected carotid bifurcation. A growing body of evidence supports the hypothesis that IC is a distinct clinicopathologic entity with characteristic imaging features. We report the case of a 34-year-old Caucasian male presenting with intense unilateral neck pain in the emergency setting. Computed tomography and ultrasonography revealed fusiform eccentric thickening of the ipsilateral carotid bifurcation without vessel narrowing...
2017: Case Reports in Radiology
https://www.readbyqxmd.com/read/29147477/vanishing-vasculitis-a-case-of-acute-necrotic-skin-findings-without-pathologic-features-of-vasculitis-from-adulterated-cocaine
#4
Adnan Asif Parvez Ghias, Patrick Brine
While the usage of illicit drugs in itself carries significant health risks and associated toxicities, drugs that are adulterated to give them volume, alter their psychogenic properties, and make them cheaper to produce are to be considered even more dangerous. Cocaine is one of them, and it is now most commonly being adulterated with levamisole. We report a case of a 37-year-old female with the chief complaint of painful skin lesions and wounds on both of her upper and lower extremities for three weeks duration...
2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29146054/lymphocytic-thrombophilic-arteritis-a-distinct-inflammatory-type-i-interferon-and-c5b-9-mediated-subcutaneous-endovasculitis
#5
Cynthia M Magro, Jad Saab
BACKGROUND: Lymphocytic thrombophilic arteritis is a recently recognized subcuticular larger vessel vasculitis characterized by striking vascular luminal thrombosis. METHODS: The clinical features, histopathology and phenotypic profile of ten patients with lymphocytic thrombophilic arteritis were explored in an attempt to better define the entity from a clinical and pathophysiologic perspective. RESULTS: The patients were all female (mean age of 43) presenting with generally asymptomatic lower and upper extremity hyperpigmented macules...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29145713/positron-emission-tomography-as-an-imaging-biomarker-in-a-prospective-longitudinal-cohort-of-patients-with-large-vessel-vasculitis
#6
Peter C Grayson, Sara Alehashemi, Armin A Bagheri, Ali Cahid Civelek, Thomas R Cupps, Mariana J Kaplan, Ashkan A Malayeri, Peter A Merkel, Elaine Novakovich, David A Bluemke, Mark A Ahlman
OBJECTIVES: To assess the clinical value of (18) F-flurodeoxyglucose (FDG) positron emission tomography (PET) in a prospective cohort of patients with large-vessel vasculitis (LVV) and disease comparators. METHODS: Patients with Takayasu's arteritis (TAK) and giant cell arteritis (GCA) were studied, along with a comparator group consisting of patients with hyperlipidemia, diseases that mimic LVV, and healthy controls. Participants underwent clinical evaluation and FDG-PET imaging, and patients with LVV underwent serial imaging at six-month intervals...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29145680/-a-rare-differential-diagnosis-of-chronic-cough
#7
Michael Dicker, Tino Schneider, Johannes von Kempis, Markus Diethelm
History and admission findings We report on a 62-year-old male patient with dry cough for 3 months, constitutional symptoms and elevated inflammatory markers. Investigations Despite extensive diagnostics no infectious, malignant or rheumatologic disease could be found. Bronchoscopy with bronchoalveolar lavage showed lymphocytosis. 18-FDG-PET/CT demonstrated increased metabolic activity of the aorta and its primary branches. Diagnosis, treatment and course We diagnosed large vessel vasculitis consistent to a subtype of giant cell arteritis (GCA) without cranial manifestation...
November 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29142188/a-case-of-microscopic-polyangiitis-with-subarachnoid-hemorrhage-and-cardiovascular-complications
#8
Sae Aratani, Yukinao Sakai, Shuichi Tsuruoka
Microscopic polyangiitis (MPA) is a primary systemic vasculitis that predominantly affects small and medium vessels. MPA is rarely complicated with central nervous system or cardiovascular disease. We report a very rare case of MPA complicated with cerebral infarction, cardiovascular disease, and fatal subarachnoid hemorrhage in a 54-year-old man. During the first six days of hospitalization the patient was diagnosed with rapid progressive glomerulonephritis (RPGN), cerebral infarction, and unstable angina...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29141676/platelets-are-activated-in-anca-associated-vasculitis-via-thrombin-pars-pathway-and-can-activate-the-alternative-complement-pathway
#9
Di Miao, Dan-Yang Li, Min Chen, Ming-Hui Zhao
BACKGROUND: In this study, we investigated the mechanism of platelet activation in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), as well as the activation of the alternative complement pathway by platelets in AAV. METHODS: CD62P and platelet-leukocyte aggregates in AAV patients were tested by flow cytometry. Platelets were stimulated by plasma from active AAV patients. The effect of the thrombin-protease-activated receptors (PARs) pathway was evaluated by blocking thrombin or PAR1 antagonists...
November 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29140936/increased-kawasaki-disease-incidence-associated-with-higher-precipitation-and-lower-temperatures-japan-1991-2004
#10
Joseph Y Abrams, Jennifer L Blase, Ermias B Belay, Ritei Uehara, Ryan A Maddox, Lawrence B Schonberger, Yosikazu Nakamura
BACKGROUND: Kawasaki disease (KD) is an acute febrile vasculitis which primarily affects children. The etiology of KD is unknown: while certain characteristics of the disease suggest an infectious origin, genetic or environmental factors may also be important. Seasonal patterns of KD incidence are well-documented, but it is unclear whether these patterns are caused by changes in climate or by other unknown seasonal effects. METHODS: The relationship between KD incidence and deviations from expected temperature and precipitation were analyzed using KD incidence data from Japanese nationwide epidemiological surveys (1991-2004) and climate data from 136 weather stations of the Japan Meteorological Agency...
November 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29139157/seronegative-granulomatosis-with-polyangiitis-presenting-with-multiple-cranial-nerve-palsies
#11
Eunhye Lee, Jynkyun Park, Seung Hong Choi, Sung-Hye Park
Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis (WG), is a rare systemic disease characterized by necrotizing granulomas and vasculitis that usually presents in the respiratory tract and renal system. Here, we report a case of anti-neutrophil cytoplasmic antibody (ANCA)-negative GPA with diagnostic difficulties. Neurologic involvement in GPA is not uncommon, with up to 50% of patients manifesting with neurologic defects; however, it is usually a late event. This patient was a 50-year-old man whose first manifestation was multiple neurologic defects without respiratory or renal symptoms...
November 14, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29136340/dermatological-addendum-to-the-2012-international-chapel-hill-consensus-conference-nomenclature-of-vasculitides
#12
Cord H Sunderkötter, Bernhard Zelger, Ko-Ron Chen, Luis Requena, Warren Piette, J Andrew Carlson, Jan Dutz, Peter Lamprecht, Alfred Mahr, Elisabeth Aberer, Victoria P Werth, David A Wetter, Seiji Kawana, Raashid Luqmani, Camille Frances, Joseph Jorizzo, J Richard Watts, Dieter Metze, Marzia Caproni, Erkan Alpsoy, Jeffrey P Callen, David Fiorentino, Peter A Merkel, Ronald J Falk, J Charles Jennette
OBJECTIVE: The objective of this project was to prepare a dermatologic addendum to the 2012 Chapel Hill consensus conference nomenclature to address vasculitides affecting the skin. The goal was to standardize names and definitions for cutaneous vasculitis. METHODS: A nominal group technique with a facilitator was used to reach a consensus using multiple face-to-face meetings, e-mail discussions, and teleconferences. RESULTS: Standardized names, definitions and descriptions are provided for cutaneous components of systemic vasculitides (e...
November 14, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29133703/cns-small-vessel-vasculitis-distinct-mri-features-and-histopathological-correlation
#13
Kamble J Harsha, Sujit A Jagtap, Tirur R Kapilamoorthy, Chandrasekharan Kesavadas, Bejoy Thomas, Neelima Radhakrishnan
BACKGROUND: Central nervous system (CNS) vasculitis is an uncommon disease, which is a diagnostic and therapeutic challenge for physicians. Large and medium vessel vasculitis is relatively easy to diagnose by angiogram compared to small vessel vasculitis, where angiograms are often normal; imaging features described till date are sensitive but not specific. PURPOSE: Here, we describe distinct magnetic resonance (MR) imaging features of CNS small vessel vasculitis...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29133684/central-nervous-system-vasculitis-imaging-simplified
#14
Harsh Rastogi
No abstract text is available yet for this article.
November 2017: Neurology India
https://www.readbyqxmd.com/read/29133683/small-vessel-cns-vasculitis-optimism-and-challenges-in-imaging-diagnosis
#15
Rakesh K Gupta
No abstract text is available yet for this article.
November 2017: Neurology India
https://www.readbyqxmd.com/read/29133608/systemic-vasculitis-with-dermatomyositis-hearing-loss-neuropathy-and-multiorgan-dysfunction
#16
Priya S Dhawan, P James B Dyck, Jennifer A Tracy, Elie Naddaf
No abstract text is available yet for this article.
November 14, 2017: Neurology
https://www.readbyqxmd.com/read/29131549/diagnosis-of-kawasaki-disease
#17
Surjit Singh, Ankur Kumar Jindal, Rakesh Kumar Pilania
Kawasaki disease (KD) is a medium vessel vasculitis with predilection for coronary arteries. Due to lack of a reliable confirmatory laboratory test, the diagnosis of KD is based on a constellation of clinical findings that appear in a typical temporal sequence. These diagnostic criteria have been modified from time to time and the most recent guidelines have been proposed by the American Heart Association (AHA) in 2017. However, several children may have incomplete or atypical forms of KD and the diagnosis can often be difficult, especially in infants and young children...
November 13, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29131037/paradoxical-reactions-anti-tumor-necrosis-factor-alpha-agents-ustekinumab-secukinumab-ixekizumab-and-others
#18
Lluís Puig
Paradoxical reactions during treatment with a biologic agent can be defined as the appearance or exacerbation of a pathological condition that usually responds to this class of drug while treating a patient for another condition, which usually remains under control (even though there may be a change in morphology or phenotype). Paradoxical reactions were initially described as isolated case reports or case series in patients treated with anti-tumor necrosis factor (TNF) α agents, first in inflammatory rheumatic diseases, later in psoriasis and inflammatory bowel disease...
2018: Current Problems in Dermatology
https://www.readbyqxmd.com/read/29130357/biological-effects-of-metal-degradation-in-hip-arthroplasties
#19
Donatella Granchi, Lucia Maria Savarino, Gabriela Ciapetti, Nicola Baldini
Metals and metal alloys are the most used materials in orthopedic implants. The focus is on total hip arthroplasty (THA) that, though well tolerated, may be associated with local and remote adverse effects in the medium-long term. This review aims to summarize data on the biological consequences of the metal implant degradation that have been attributed predominantly to metal-on-metal (MoM) THA. Local responses to metals consist of a broad clinical spectrum ranging from small asymptomatic tissue lesions to severe destruction of bone and soft tissues, which are designated as metallosis, adverse reactions to metal debris (ARMD), aseptic lymphocytic vasculitis associated lesion (ALVAL), and pseudotumors...
November 13, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29130124/systemic-autoimmune-diseases-complicated-with-hydrocephalus-pathogenesis-and-management
#20
REVIEW
Hexiang Yin, Junji Wei, Li Wang, Liying Cui, Renzhi Wang
Systemic autoimmune diseases (SAIDs) represent a group of syndromes involving at least two organ systems. Classical SAIDs include connective tissue diseases, vasculitis, and granulomatous diseases, many of which involve the nervous system and result in different neurological manifestations. Hydrocephalus can be a rare but lethal complication of various SAIDs, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), sarcoidosis, and primary vasculitis. However, the pathogenesis of SAIDs complicated with different types of hydrocephalus is varied and difficult to determine using the existing published data, and various manifestations and expressive forms of the conditions bring a substantial challenge to a timely clinical diagnosis and treatment...
November 12, 2017: Neurosurgical Review
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