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https://www.readbyqxmd.com/read/28185121/the-association-between-coenzyme-q10-concentrations-in-follicular-fluid-with-embryo-morphokinetics-and-pregnancy-rate-in-assisted-reproductive-techniques
#1
Süleyman Akarsu, Funda Gode, Ahmet Zeki Isik, Zeliha Günnur Dikmen, Mustafa Agah Tekindağ
PURPOSE: This study seeks to evaluate the association between follicular fluid (FF) coenzyme Q10 (CoQ10) levels, embryo morphokinetics, and pregnancy rate. METHODS: Sixty infertile patients who underwent intracytoplasmic sperm injection (ICSI) cycles were included in the study. For each patient, CoQ10 level of the follicular fluid was measured by high-performance liquid chromatography system. After the ICSI of each oocyte, the relationship between the level of CoQ10 content of each follicular fluid, the subsequent embryo quality, and embryo morphokinetics was investigated...
February 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28142289/time-lapse-imaging-is-it-time-to-incorporate-this-technology-into-routine-clinical-practice
#2
Priya Bhide, Abha Maheshwari, Rachel Cutting, Susan Seenan, Anita Patel, Khalid Khan, Roy Homburg
Time-lapse imaging (TLI) systems for embryo incubation, assessment and selection are a novel technology available to in vitro fertilization (IVF) clinics. However, there is uncertainty about their clinical and cost-effectiveness and insufficient good quality evidence to warrant their routine use. Despite this, enthusiastic commercial marketing and slipping clinical equipoise have led to the widespread hasty introduction of this technology into practice, often at a considerable expense to the patient. We have reviewed the published literature and aim to summarize the strengths, weaknesses, opportunities and threats of these systems...
February 1, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28139236/time-lapse-imaging-reveals-differences-in-growth-dynamics-of-embryos-after-in%C3%A2-vitro-maturation-compared-with-conventional-stimulation
#3
Sabine Roesner, Jens Erik Dietrich, Julia Weigert, Markus Montag, Bettina Toth, Thomas Strowitzki
OBJECTIVE: To study the impact of in vitro maturation (IVM) on embryonal development with the use of time-lapse imaging. DESIGN: Retrospective case-control study. SETTING: University hospital. PATIENT(S): In total, 294 embryos were cultured after intracytoplasmic sperm injection treatment of three groups: patients with polycystic ovary syndrome (PCOS) and IVM (n = 105; group 1 [G1]), patients after conventional stimulation without PCOS (n = 115; G2) and with PCOS (n = 74; G3)...
January 27, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28069186/examining-the-efficacy-of-six-published-time-lapse-imaging-embryo-selection-algorithms-to-predict-implantation-to-demonstrate-the-need-for-the-development-of-specific-in-house-morphokinetic-selection-algorithms
#4
Amy Barrie, Roy Homburg, Garry McDowell, Jeremy Brown, Charles Kingsland, Stephen Troup
OBJECTIVE: To study the efficacy of six embryo-selection algorithms (ESAs) when applied to a large, exclusive set of known implantation embryos. DESIGN: Retrospective, observational analysis. SETTING: Fertility treatment center. PATIENT(S): Women undergoing a total of 884 in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment cycles (977 embryos) between September 2014 and September 2015 with embryos cultured using G-TL (Vitrolife) at 5% O2, 89% N2, 6% CO2, at 37°C in EmbryoScope instruments...
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28069182/one-for-all-or-all-for-one-the%C3%A2-evolution-of-embryo-morphokinetics
#5
EDITORIAL
Marcos Meseguer, Antonio Pellicer
No abstract text is available yet for this article.
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28064422/improved-detection-of-mineral-oil-toxicity-using-an-extended-mouse-embryo-assay
#6
Alessandra J Ainsworth, Jolene R Fredrickson, Dean E Morbeck
PURPOSE: Successful in vitro fertilization (IVF) relies on sound laboratory methods and culture conditions which depend on sensitive quality control (QC) testing. This study aimed to improve the sensitivity of mouse embryo assays (MEA) for detection of mineral oil toxicity. METHODS: Five experiments were conducted to study modifications of the standard mouse embryo assay (MEA) in order to improve sensitivity using clinical grade mineral oil with known peroxide concentrations...
January 7, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28050955/the-impact-of-male-age-on-embryo-quality-a-retrospective-study-using-time-lapse-imaging
#7
Guilherme R F Rosário, Diana S Vidal, Adriana V Silva, Antônio C C Franco
OBJECTIVE: This study aimed to correlate male age with embryo morphokinetic parameters on D3 considering the timing and the exact moment of embryo cleavage. METHODS: Time-lapse imaging was used to produce an ideal cleavage curve for the embryos analyzed. The percentage of embryos under the curve was analyzed and correlated with male age. RESULTS: 32.6% of the embryos from patients aged 28-33 years were under the curve; 36.2% of the embryos from patients aged 34-39 years were under the curve; 41...
December 1, 2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/27980237/prediction-of-blastocyst-development-and-implantation-potential-in-utero-based-on-the-third-cleavage-and-compaction-times-in-mouse-pre-implantation-embryos
#8
Jihyun Kim, Seok Hyun Kim, Jin Hyun Jun
Cytokinesis and cell division during pre-implantation embryonic development occur as an orchestrated spatiotemporal program. Cleavage, compaction, and blastulation in pre-implantation embryos are essential for successful implantation and pregnancy. Their alteration is associated with chromosomal imbalance and loss of developmental competence. In this study, we evaluated the time of cleavage and compaction as predictors for in vitro pre- and peri-implantation development and in utero implantation potential by time-lapse monitoring...
December 16, 2016: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/27958618/morphokinetic-parameters-as-a-source-of-information-concerning-embryo-developmental-and-implantation-potential
#9
Robert Milewski, Jan Czerniecki, Agnieszka Kuczyńska, Bożena Stankiewicz, Waldemar Kuczyński
OBJECTIVES: The aim of the study was to present the results of time-lapse observation and to verify whether morphokinetic parameters are associated with embryo developmental and implantation potential. MATERIAL AND METHODS: The analysed data concern the development of 1,060 embryos, 898 of which (84.72%) achieved the blastocyst stage and 307 were transferred into the uterine cavity. As a result, 126 (41.04%) biochemical pregnancies and 109 (35.50%) clinical pregnancies were observed...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27943109/morphokinetics-of-vitrified-and-warmed-blastocysts-predicts-implantation-potential
#10
T Ebner, P Oppelt, E Radler, C Allerstorfer, A Habelsberger, R B Mayer, O Shebl
PURPOSE: It was studied whether morphokinetics of blastocoele re-expansion and hatching in vitrified-warmed blastocysts is predictive of implantation, clinical pregnancy, and live birth. METHODS: In 144 patients aiming for single warmed blastocyst transfer, blastocysts were cultured in a new time-lapse system (Miri® TL) immediately after warming. Video sequences with an image interval of 5 min were annotated and the corresponding morphokinetic variables were correlated with pregnancy outcome...
December 9, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27939508/time-lapse-morphokinetic-assessment-has-low-to-moderate-ability-to-predict-euploidy-when-patient-and-ovarian-stimulation-related-factors-are-taken-into-account-with-the-use-of-clustered-data-analysis
#11
Sezcan Mumusoglu, Irem Yarali, Gurkan Bozdag, Pınar Ozdemir, Mehtap Polat, Lale Karakoc Sokmensuer, Hakan Yarali
OBJECTIVE: To study whether time-lapse morphokinetic (TLM) assessment predicts ploidy status when patient- and ovarian stimulation-related factors are taken into account. DESIGN: Retrospective cohort study. SETTING: Private IVF clinic. PATIENT(S): In total, 103 consecutive patients (415 blastocysts) were included. All embryos were individually cultured in a time-lapse incubator from intracytoplasmic sperm injection up to trophectoderm biopsy...
February 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/27938863/embryos-with-morphokinetic-abnormalities-may-develop-into-euploid-blastocysts
#12
C Lagalla, N Tarozzi, R Sciajno, D Wells, M Di Santo, M Nadalini, V Distratis, A Borini
Irregular cleavage divisions are expected to produce chromosomally deviant embryos. We investigated whether embryos from irregular cleavages could develop into euploid blastocysts, and, if so, whether any evidence existed of a self-correction mechanism of the embryo. We also investigated the role of different dynamic aspects of morula compaction in this process. A total of 791 embryos from 141 patients undergoing pre-implantation genetic screening were retrospectively analysed using a time-lapse imaging system, and multiple cell divisions were evaluated...
February 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27816230/type-of-chromosome-abnormality-affects-embryo-morphology-dynamics
#13
Maria Del Carmen Nogales, Fernando Bronet, Natalia Basile, Eva María Martínez, Alberto Liñán, Lorena Rodrigo, Marcos Meseguer
OBJECTIVE: To study the differences in the cleavage time between types of embryo chromosomal abnormalities and elaborate algorithm to exclude aneuploid embryos according to the likelihood to be euploid. DESIGN: Retrospective cohort study. SETTING: University affiliated private center. PATIENT(S): Preimplantational genetic screening patients (n = 112) including cases of advanced maternal age, repeated implantation failure, and recurrent miscarriage...
January 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/27760750/random-allocation-of-blastomere-descendants-to-the-trophectoderm-and-icm-of-the-bovine-blastocyst
#14
Lessly P Sepulveda-Rincon, Delphine Dube, Pierre Adenot, Ludivine Laffont, Sylvie Ruffini, Laurence Gall, Bruce K Campbell, Veronique Duranthon, Nathalie Beaujean, Walid E Maalouf
The first lineage specification during mammalian embryo development can be visually distinguished at the blastocyst stage. Two cell lineages are observed on the embryonic-abembryonic axis of the blastocyst: the inner cell mass and the trophectoderm. The timing and mechanisms driving this process are still not fully understood. In mouse embryos, cells seem prepatterned to become certain cell lineage because the first cleavage plane has been related with further embryonic-abembryonic axis at the blastocyst stage...
December 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27720247/time-lapse-embryo-imaging-and-morphokinetic-profiling-towards-a-general-characterisation-of-embryogenesis
#15
REVIEW
A A Mandawala, S C Harvey, T K Roy, K E Fowler
In vitro fertilisation is an effective method of assisted reproductive technology in both humans and certain non-human animal species. In most species, specifically, in humans and livestock, high in vitro fertilisation success rates are achieved via the transfer of embryos with the highest implantation and subsequent developmental potential. In order to reduce the risk of multiple gestation, which could be a result of the transfer of several embryos per cycle, restrictive transfer policies and methods to improve single embryo selection have been implemented...
November 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27696105/blastomere-biopsy-for-pgd-delays-embryo-compaction-and-blastulation-a-time-lapse-microscopic-analysis
#16
Liron Bar-El, Yael Kalma, Mira Malcov, Tamar Schwartz, Shaul Raviv, Tania Cohen, Hadar Amir, Yoni Cohen, Adi Reches, Ami Amit, Dalit Ben-Yosef
PURPOSE: The purpose of the study was to explore the effect of blastomere biopsy for preimplantation genetic diagnosis (PGD) on the embryos' dynamics, further cleavage, development, and implantation. METHODS: The study group included 366 embryos from all PGD treatments (September 2012 to June 2014) cultured in the EmbryoScope™ time-lapse monitoring system. The control group included all intracytoplasmic sperm injection (ICSI) embryos cultured in EmbryoScope™ until day 5 during the same time period (385 embryos)...
November 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27678484/microfluidics-for-mammalian-embryo-culture-and-selection-where-do-we-stand-now
#17
Séverine Le Gac, Verena Nordhoff
The optimization of in-vitro culture conditions and the selection of the embryo(s) with the highest developmental competence are essential components in an ART program. Culture conditions are manifold and they underlie not always evidence-based research but also trends entering the IVF laboratory. At the moment, the idea of using sequential media according to the embryo requirements has been given up in favor of the use of single step media in an uninterrupted manner due to practical issues such as time-lapse incubators...
September 27, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27665055/morphokinetics-of-human-blastocyst-expansion-in-vitro
#18
T T F Huang, K Chinn, T Kosasa, H J Ahn, B Kessel
Time-lapse imaging offers new tools to study dynamic processes of development such as blastocyst formation and expansion. This study quantitatively describes expansion in human blastocysts from donated oocytes. Measurements of hourly interval rate of changes in the blastocoel cross-sectional area revealed oscillatory pulses having 2-4 h periodicities. Two types of oscillations were distinguished. An E-Type ('expansion') had positive peak and positive or slightly negative trough interval rate of change values, and these characterized most of the expansion period...
December 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27628754/novel-embryo-selection-techniques-to-increase-embryo-implantation-in-ivf-attempts
#19
George Α Sigalos, Olga Triantafyllidou, Nikos F Vlahos
PURPOSE: The final success of an IVF attempt depends on several steps and decisions taken during the ovarian stimulation, the oocyte retrieval, the embryo culture and the embryo transfer. The final selection of the embryos most likely to implant is the final step in this process and the responsibility of the lab. Apart from strict morphologic criteria that historically have been used in embryo selection, additional information on genetic, metabolomic and morphokinetic characteristics of the embryo is recently combined to morphology to select the embryo most likely to produce a pregnancy...
September 15, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27609980/development-of-a-generally-applicable-morphokinetic-algorithm-capable-of-predicting-the-implantation-potential-of-embryos-transferred-on-day-3
#20
Bjørn Molt Petersen, Mikkel Boel, Markus Montag, David K Gardner
STUDY QUESTION: Can a generally applicable morphokinetic algorithm suitable for Day 3 transfers of time-lapse monitored embryos originating from different culture conditions and fertilization methods be developed for the purpose of supporting the embryologist's decision on which embryo to transfer back to the patient in assisted reproduction? SUMMARY ANSWER: The algorithm presented here can be used independently of culture conditions and fertilization method and provides predictive power not surpassed by other published algorithms for ranking embryos according to their blastocyst formation potential...
October 2016: Human Reproduction
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