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https://www.readbyqxmd.com/read/29745164/-predictive-model-based-multimetric-index-of-macroinvertebrates-for-river-health-assessment
#1
Kai Chen, Hai Yan Yu, Ji Wei Zhang, Bei Xin Wang, Qiu Wen Chen
Improving the stability of integrity of biotic index (IBI; i.e., multi-metric indices, MMI) across temporal and spatial scales is one of the most important issues in water ecosystem integrity bioassessment and water environment management. Using datasets of field-based macroinvertebrate and physicochemical variables and GIS-based natural predictors (e.g., geomorphology and climate) and land use variables collected at 227 river sites from 2004 to 2011 across the Zhejiang Province, China, we used random forests (RF) to adjust the effects of natural variations at temporal and spatial scales on macroinvertebrate metrics...
June 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29732017/evaluation-of-strain-in-mandibular-denture-supporting-area-in-three-different-occlusal-schemes-during-jaw-movements
#2
Ali Hafezeqoran, Roodabeh Koodaryan, Seyed Gholamreza Noorazar, Masoud Hajialilue-Bonab, Mehran Hassanzadeh, Neda Yasamineh
Background. Various occlusal schemes have been introduced over the years to enhance the stability, comfort, beauty and function of complete denture, of which lingualized, bilateral balanced and monoplane occlusions are the most recommended. The aim of this study was to compare the strain in mandibular denture-supporting structures in three different occlusal schemes. Methods. Two mandibular and maxillary models were simulated using epoxy resin, and strain gauges were embedded on each side of the mandible in mental foramen, buccal shelf and distolingual area...
2018: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/29625202/yeast-inner-subunit-pa-nz-1-labeling-strategy-for-accurate-subunit-identification-in-a-macromolecular-complex-through-cryo-em-analysis
#3
Huping Wang, Wenyu Han, Junichi Takagi, Yao Cong
Cryo-electron microscopy (cryo-EM) has been established as one of the central tools in the structural study of macromolecular complexes. Although intermediate- or low-resolution structural information through negative staining (NS) or cryo-EM analysis remains highly valuable, we lack general and efficient ways to achieve unambiguous subunit identification in these applications. Here, we took advantage of the extremely high affinity between a dodecapeptide "PA" tag and the NZ-1 antibody Fab fragment to develop an efficient "yeast inner-subunit PA-NZ-1 labeling" (YISPANL) strategy that when combined with cryo-EM could precisely identify subunits in macromolecular complexes...
April 3, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29608700/trophoblast-retrieval-and-isolation-from-the-cervix-origins-of-cervical-trophoblasts-and-their-potential-value-for-risk-assessment-of-ongoing-pregnancies
#4
Gerit Moser, Sascha Drewlo, Berthold Huppertz, D Randall Armant
BACKGROUND: Early during human development, the trophoblast lineage differentiates to commence placentation. Where the placenta contacts the uterine decidua, extravillous trophoblast (EVT) cells differentiate and invade maternal tissues. EVT cells, identified by expression of HLA-G, invade into uterine blood vessels (endovascular EVT), as well as glands (endoglandular EVT), and open such luminal structures towards the intervillous space of the placenta. Endoglandular invasion diverts the contents of uterine glands to the intervillous space, while glands near the margin of the placenta that also contain endoglandular EVT cells open into the reproductive tract...
March 28, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29608203/teaching-an-old-dog-new-trics-re-evaluating-transfusion-triggers-in-high-risk-cardiac-surgery
#5
EDITORIAL
Jonathan H Chow, Michael A Mazzeffi, Kenichi A Tanaka
No abstract text is available yet for this article.
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29531365/the-tric-chaperonin-controls-reovirus-replication-through-outer-capsid-folding
#6
Jonathan J Knowlton, Isabel Fernández de Castro, Alison W Ashbrook, Daniel R Gestaut, Paula F Zamora, Joshua A Bauer, J Craig Forrest, Judith Frydman, Cristina Risco, Terence S Dermody
Viruses are molecular machines sustained through a life cycle that requires replication within host cells. Throughout the infectious cycle, viral and cellular components interact to advance the multistep process required to produce progeny virions. Despite progress made in understanding the virus-host protein interactome, much remains to be discovered about the cellular factors that function during infection, especially those operating at terminal steps in replication. In an RNA interference screen, we identified the eukaryotic chaperonin T-complex protein-1 (TCP-1) ring complex (TRiC; also called CCT for chaperonin containing TCP-1) as a cellular factor required for late events in the replication of mammalian reovirus...
April 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29531219/tric-controls-transcription-resumption-after-uv-damage-by-regulating-cockayne-syndrome-protein-a
#7
Alex Pines, Madelon Dijk, Matthew Makowski, Elisabeth M Meulenbroek, Mischa G Vrouwe, Yana van der Weegen, Marijke Baltissen, Pim J French, Martin E van Royen, Martijn S Luijsterburg, Leon H Mullenders, Michiel Vermeulen, Wim Vermeulen, Navraj S Pannu, Haico van Attikum
Transcription-blocking DNA lesions are removed by transcription-coupled nucleotide excision repair (TC-NER) to preserve cell viability. TC-NER is triggered by the stalling of RNA polymerase II at DNA lesions, leading to the recruitment of TC-NER-specific factors such as the CSA-DDB1-CUL4A-RBX1 cullin-RING ubiquitin ligase complex (CRLCSA ). Despite its vital role in TC-NER, little is known about the regulation of the CRLCSA complex during TC-NER. Using conventional and cross-linking immunoprecipitations coupled to mass spectrometry, we uncover a stable interaction between CSA and the TRiC chaperonin...
March 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29499109/shear-thickening-electrolyte-built-from-sterically-stabilized-colloidal-particles
#8
Brian H Shen, Beth L Armstrong, Mathieu Doucet, Luke Heroux, James F Browning, Michael Agamalian, Wyatt E Tenhaeff, Gabriel M Veith
We present a method to prepare shear thickening electrolytes consisting of silica nanoparticles in conventional liquid electrolytes with limited flocculation. These electrolytes rapidly and reversibly stiffen to solidlike behaviors in the presence of external shear or high impact, which is promising for improved lithium ion battery safety, especially in electric vehicles. However, in initial chemistries the silica nanoparticles aggregate and/or sediment in solution over time. Here, we demonstrate steric stabilization of silica colloids in conventional liquid electrolyte via surface-tethered PMMA brushes, synthesized via surface-initiated atom transfer radical polymerization...
March 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29433162/examining-the-methodology-of-the-transfusion-requirements-in-cardiac-surgery-iii-trics-iii-trial-third-time-s-a-charm
#9
EDITORIAL
Samuel DeMaria, Elliott Bennett-Guerrero
No abstract text is available yet for this article.
February 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29403048/development-of-a-yeast-internal-subunit-egfp-labeling-strategy-and-its-application-in-subunit-identification-in-eukaryotic-group-ii-chaperonin-tric-cct
#10
Yunxiang Zang, Huping Wang, Zhicheng Cui, Mingliang Jin, Caixuan Liu, Wenyu Han, Yanxing Wang, Yao Cong
Unambiguous subunit assignment in a multicomponent complex is critical for thorough understanding of the machinery and its functionality. The eukaryotic group II chaperonin TRiC/CCT folds approximately 10% of cytosolic proteins and is important for the maintenance of cellular homeostasis. TRiC consists of two rings and each ring has eight homologous but distinct subunits. Unambiguous subunit identification of a macromolecular machine such as TRiC through intermediate or low-resolution cryo-EM map remains challenging...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29401443/sarcoplasmic-reticulum-ca-2-release-uses-a-cascading-network-of-intra-sr-and-channel-countercurrents
#11
Vilmos Zsolnay, Michael Fill, Dirk Gillespie
In muscle, Ca2+ release from the sarcoplasmic reticulum (SR) into the cytosol is mediated through the ryanodine receptors (RyRs) and sustained by countercurrents that keep the SR membrane potential near 0 mV. Likewise, Ca2+ reuptake by the sarco/endoplasmic reticulum Ca2+ ATPase pump requires countercurrent. Although evidence has suggested that TRIC K+ channels and/or RyR K+ influx provide these countercurrents, the exact sources have not yet been determined. We used an equivalent circuit compartment model of a cardiac SR, the surrounding cytosol, and the dyadic cleft to probe the sources of countercurrent during a complete cardiac cycle...
January 23, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29326843/risk-of-acute-kidney-injury-in-patients-randomized-to-a-restrictive-versus-liberal-approach-to-red-blood-cell-transfusion-in-cardiac-surgery-a-substudy-protocol-of-the-transfusion-requirements-in-cardiac-surgery-iii-noninferiority-trial
#12
Amit X Garg, Nadine Shehata, Shay McGuinness, Richard Whitlock, Dean Fergusson, Ron Wald, Chirag Parikh, Sean M Bagshaw, Boris Khanykin, Alex Gregory, Summer Syed, Gregory M T Hare, Meaghan S Cuerden, Kevin E Thorpe, Judith Hall, Subodh Verma, Pavel S Roshanov, Jessica M Sontrop, C David Mazer
Background: When safe to do so, avoiding blood transfusions in cardiac surgery can avoid the risk of transfusion-related infections and other complications while protecting a scarce resource and reducing costs. This protocol describes a kidney substudy of the Transfusion Requirements in Cardiac Surgery III (TRICS-III) trial, a multinational noninferiority randomized controlled trial to determine whether the risk of major clinical outcomes in patients undergoing planned cardiac surgery with cardiopulmonary bypass is no greater with a restrictive versus liberal approach to red blood cell transfusion...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29320728/in-vivo-function-of-the-chaperonin-tric-in-%C3%AE-actin-folding-during-sarcomere-assembly
#13
Joachim Berger, Silke Berger, Mei Li, Arie S Jacoby, Anders Arner, Navid Bavi, Alastair G Stewart, Peter D Currie
The TCP-1 ring complex (TRiC) is a multi-subunit group II chaperonin that assists nascent or misfolded proteins to attain their native conformation in an ATP-dependent manner. Functional studies in yeast have suggested that TRiC is an essential and generalized component of the protein-folding machinery of eukaryotic cells. However, TRiC's involvement in specific cellular processes within multicellular organisms is largely unknown because little validation of TRiC function exists in animals. Our in vivo analysis reveals a surprisingly specific role of TRiC in the biogenesis of skeletal muscle α-actin during sarcomere assembly in myofibers...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29303446/combination-ipilimumab-and-radiosurgery-for-brain-metastases-tumor-edema-and-adverse-radiation-effects
#14
Kevin Diao, Shelly X Bian, David M Routman, Cheng Yu, Paul E Kim, Naveed A Wagle, Michael K Wong, Gabriel Zada, Eric L Chang
OBJECTIVE Tumor and edema volume changes of brain metastases after stereotactic radiosurgery (SRS) and ipilimumab are not well described, and there is concern regarding the safety of combination treatment. The authors evaluated tumor, edema, and adverse radiation-induced changes after SRS with and without ipilimumab and identified associated risk factors. METHODS This single-institution retrospective study included 72 patients with melanoma brain metastases treated consecutively with upfront SRS from 2006 to 2015...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29286527/experience-of-correcting-endothelial-dysfunction-in-children-residents-of-radioactively-contaminated-areas-by-nitric-oxide-potential-donator-citrulline
#15
Ye I Stepanova, I Ye Kolpakov, V M Zygalo, V Yu Vdovenko, V H Kondrashova, O S Leonovich, V V Kryzhanivska
OBJECTIVE: to determine the effectiveness of citrulline use for correcting endothelial dysfunction in children resi dents of radioactively contaminated areas. MATERIALS AND METHODS: A group of children residents of radioactively contaminated areas with the presence of clinical and paraclinical signs of endothelial dysfunction was selected to assess the effectiveness of correcting endothelial dysfunction by the usage of NO potential donator - citrulline according to the data of selective screen ing...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29286514/cardiovascular-diseases-and-systolic-function-of-left-ventricle-in-clean-up-workers-of-chernobyl-accident-based-on-30-years-follow-up
#16
O D Bazyka, D O Belyi
OBJECTIVE: To study the dynamics of circulatory system diseases during the 30 year period after irradiation, changes in the status of systolic function of heart left ventricle (LV) and the features of its remodeling in clean up workers (CW) of the accident at the Chernobyl nuclear power plant (ChNPP). MATERIAL AND METHODS: It was examined 144 CW at ChNPP, including 52 patients, who survived acute radiation sick ness (ARS) grade of severity 1-3, and 105 non irradiated persons (control group - CG)...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29281836/a-global-interactome-map-of-the-dengue-virus-ns1-identifies-virus-restriction-and-dependency-host-factors
#17
Mohamed Lamine Hafirassou, Laurent Meertens, Claudia Umaña-Diaz, Athena Labeau, Ophelie Dejarnac, Lucie Bonnet-Madin, Beate M Kümmerer, Constance Delaugerre, Philippe Roingeard, Pierre-Olivier Vidalain, Ali Amara
Dengue virus (DENV) infections cause the most prevalent mosquito-borne viral disease worldwide, for which no therapies are available. DENV encodes seven non-structural (NS) proteins that co-assemble and recruit poorly characterized host factors to form the DENV replication complex essential for viral infection. Here, we provide a global proteomic analysis of the human host factors that interact with the DENV NS1 protein. Combined with a functional RNAi screen, this study reveals a comprehensive network of host cellular processes involved in DENV infection and identifies DENV host restriction and dependency factors...
December 26, 2017: Cell Reports
https://www.readbyqxmd.com/read/29273477/transfusion-requirements-in-cardiac-surgery-iii-trics-iii-study-design-of-a-randomized-controlled-trial
#18
Nadine Shehata, Richard Whitlock, Dean A Fergusson, Kevin E Thorpe, Charlie MacAdams, Hilary P Grocott, Fraser Rubens, Stephen Fremes, Francois Lellouche, Sean Bagshaw, Alistair Royse, Peter M Rosseel, Greg Hare, Etienne De Medicis, Christopher Hudson, Emilie Belley-Cote, Daniel Bainbridge, Blaine Kent, Andrew Shaw, Kelly Byrne, Summer Syed, Colin F Royse, Shay McGuiness, Judith Hall, C David Mazer
OBJECTIVES: To determine if a restrictive transfusion threshold is noninferior to a higher threshold as measured by a composite outcome of mortality and serious morbidity. DESIGN: Transfusion Requirements in Cardiac Surgery (TRICS) III was a multicenter, international, open-label randomized controlled trial of two commonly used transfusion strategies in patients having cardiac surgery using a noninferiority trial design (ClinicalTrials.gov number, NCT02042898). SETTING: Eligible patients were randomized prior to surgery in a 1:1 ratio...
February 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29224333/ferroelectricity-and-piezoelectricity-in-free-standing-polycrystalline-films-of-plastic-crystals
#19
Jun Harada, Naho Yoneyama, Seiya Yokokura, Yukihiro Takahashi, Atsushi Miura, Noboru Kitamura, Tamotsu Inabe
Plastic crystals represent a unique compound class that is often encountered in molecules with globular structures. The highly symmetric cubic crystal structure of plastic crystals endows these materials with multiaxial ferroelectricity that allows a three-dimensional realignment of the polarization axes of the crystals, which cannot be achieved using conventional molecular ferroelectric crystals with low crystal symmetry. In this work, we focused our attention on malleability as another characteristic feature of plastic crystals...
January 10, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29151917/downregulation-of-lipolysis-stimulated-lipoprotein-receptor-promotes-cell-invasion-via-claudin-1-mediated-matrix-metalloproteinases-in-human-endometrial-cancer
#20
Hiroshi Shimada, Seiro Satohisa, Takayuki Kohno, Takumi Konno, Ken-Ichi Takano, Syunta Takahashi, Tsubasa Hatakeyama, Chihiro Arimoto, Tsuyoshi Saito, Takashi Kojima
Lipolysis-stimulated lipoprotein receptor (LSR) is a novel molecule present at tricellular contacts which recruits tricellulin (TRIC), a molecular component of tricellular tight junctions (tTJs). LSR and TRIC are colocalized with the bicellular tight junction (bTJ) protein claudin (CLDN)-1-based tight junction strands at tricellular corners. Knockdown of LSR in normal epithelial cells affects tTJ formation and the epithelial barrier function. In cancer cells knockdown of LSR has been demonstrated to increase cell invasion...
December 2017: Oncology Letters
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