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Heat shock proteins

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https://www.readbyqxmd.com/read/28731175/heat-shock-induced-hikeshi-protects-cell-viability-via-nuclear-translocation-of-heat-shock-protein-70
#1
Toru Yanoma, Kyoichi Ogata, Takehiko Yokobori, Munenori Ide, Erito Mochiki, Yoshitaka Toyomasu, Mitsuhiro Yanai, Norimichi Kogure, Akiharu Kimura, Masaki Suzuki, Nobuhiro Nakazawa, Tuya Bai, Tetsunari Oyama, Takayuki Asao, Ken Shirabe, Hiroyuki Kuwano
Heat shock proteins (HSPs), particularly HSP70, help restore normal cellular function following damage caused by stressors. HSP expression in tumor tissues indicates cancer progression, and while the development of HSP inhibitors is progressing, these substances are not widely used to treat cancer. HIKESHI (C11orf73) does not control the intracellular movement of HSP70 at normal temperatures; however, it does regulate the function and movements of HSP70 during heat shock. In this study, we examined the intracellular movement of HSP70 during heat shock to investigate the significance of HIKESHI expression in gastric cancer (GC) and determine if HIKESHI inhibition has cytotoxic effects...
July 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28730968/modulation-of-the-immune-system-for-the-treatment-of-glaucoma
#2
Katharina Bell, Nadine von Thun Und Hohenstein-Blaul, Julia Teister, Franz H Grus
At present intraocular pressure (IOP) lowering therapies are the only approach to treat glaucoma. Neuroprotective strategies to protect the retinal ganglion cells (RGC) from apoptosis are lacking to date. Results from clinical studies revealed altered immunoreactivities against retinal and optic nerve antigens in sera and aqueous humor of glaucoma patients and point toward an autoimmune involvement in glaucomatous neurodegeneration and RGC death. IgG accumulations along with plasma cells were found localised in human glaucomatous retinae in a pro-inflammatory environment possibly maintained by microglia...
July 19, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28730731/induction-of-stress-and-immune-associated-genes-in-the-indian-meal-moth-plodia-interpunctella-against-envenomation-by-the-ectoparasitoid-bracon-hebetor
#3
Tahir Shafeeq, Zain UlAbdin, Kyeong-Yeoll Lee
Envenomation is an important process in parasitism by parasitic wasps; it suppresses the immune and development of host insects. However, the molecular mechanisms of host responses to envenomation are not yet clear. This study aimed to determine the transcription-level responses of the Indian meal moth Plodia interpunctella against envenomation of the ectoparasitoid Bracon hebetor. Quantitative real-time reverse-transcription PCR was used to determine the transcriptional changes of 13 selected genes, which are associated with development, metabolism, stress, or immunity, in the feeding and wandering fifth instar larvae over a 4-day period after envenomation...
July 21, 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/28730576/effects-of-boron-supplementation-on-expression-of-hsp70-in-the-spleen-of-african-ostrich
#4
Khaliq Haseeb, Jing Wang, Ke Xiao, Ke-Li Yang, Peng-Peng Sun, Xing-Tong Wu, You Luo, Hui Song, Hua-Zhen Liu, Ju-Ming Zhong, Ke-Mei Peng
Increased synthesis of heat shock protein 70 (Hsp70) occurs in prokaryotes and eukaryotes in response to physiological, environmental, and chemical exposures, thus allowing the cell survival from fatal conditions. Hsp70 cytoprotective properties may be clarified by its anti-apoptotic function. Boron has been reported to play an essential role in various organ developments and metabolisms. However, it is not known if boron is also able to modulate the Hsp70. In the present study, the actions of boron on ostrich spleen and expression level of Hsp70 were investigated...
July 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28730091/aberrant-expression-of-genes-and-proteins-in-pterygium-and-their-implications-in-the-pathogenesis
#5
REVIEW
Qing-Yang Feng, Zi-Xuan Hu, Xi-Ling Song, Hong-Wei Pan
Pterygium is a common ocular surface disease induced by a variety of factors. The exact pathogenesis of pterygium remains unclear. Numbers of genes and proteins are discovered in pterygium and they function differently in the occurrence and development of this disease. We searched the Web of Science and PubMed throughout history for literatures about the subject. The keywords we used contain pterygium, gene, protein, angiogenesis, fibrosis, proliferation, inflammation, pathogenesis and therapy. In this review, we summarize the aberrant expression of a range of genes and proteins in pterygium compared with normal conjunctiva or cornea, including growth factors, matrix metalloproteinases and tissue inhibitors of metalloproteinases, interleukins, tumor suppressor genes, proliferation related proteins, apoptosis related proteins, cell adhesion molecules, extracellular matrix proteins, heat shock proteins and tight junction proteins...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730074/protection-of-retinal-ganglion-cells-against-optic-nerve-injury-by-induction-of-ischemic-preconditioning
#6
Xia Liu, Jiu-Ping Liang, Ou Sha, Song-Juan Wang, Heng-Guo Li, Eric Y P Cho
AIM: To explore if ischemic preconditioning (IPC) can enhance the survival of retinal ganglion cells (RGCs) after optic nerve axotomy. METHODS: Twenty-four hours prior to retinal ischemia 60min or axotomy, IPC was applied for ten minutes in groups of (n=72) animals. The survival of RGCs, the cellular expression of heat shock protein 27 (HSP27) and heat shock protein 70 (HSP70) and the numbers of retinal microglia in the different groups were quantified at 7 and 14d post-injury...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729925/patterns-of-production-of-collagen-rich-deposits-in-peripheral-nerves-in-response-to-injury-a-pilot-study-in-a-rabbit-model
#7
Michael Rivlin, Andrew Miller, Jacob Tulipan, Pedro K Beredjiklian, Mark L Wang, Jolanta Fertala, Andrzej Steplewski, James Kostas, Andrzej Fertala
INTRODUCTION: Although collagen-rich deposits are the main component of neural scars, the patterns of their formation are ill defined. Essential to the biosynthesis of collagen fibrils are enzymes catalyzing posttranslational modifications and chaperones that control the formation of the collagen triple helix. Prolyl-4-hydroxylase (P4H) and heat shock protein-47 (HSP47) play a key role, and their production is upregulated during scar formation in human tissues. Alpha smooth muscle actin (αSMA) is also produced during fibrotic processes in myofibroblasts that participate in fibrotic response...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28729874/systematic-analysis-of-hsf-family-genes-in-the-brassica-napus-genome-reveals-novel-responses-to-heat-drought-and-high-co2-stresses
#8
Xiaoyi Zhu, Chunqian Huang, Liang Zhang, Hongfang Liu, Jinhui Yu, Zhiyong Hu, Wei Hua
Drought and heat stress are major causes of lost plant crop yield. In the future, high levels of CO2, in combination of other abiotic stress factors, will become a novel source of stress. Little is known of the mechanisms involved in the acclimation responses of plants to this combination of abiotic stress factors, though it has been demonstrated that heat shock transcription factors (Hsfs) are involved in plant response to various abiotic stresses. In this study, we performed a genome-wide identification and a systematic analysis of genes in the Hsf gene family in Brassica napus...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28727798/cloning-and-expression-of-genes-encoding-heat-shock-proteins-in-liriomyza-trifolii-and-comparison-with-two-congener-leafminer-species
#9
Ya-Wen Chang, Jing-Yun Chen, Ming-Xing Lu, Yuan Gao, Zi-Hua Tian, Wei-Rong Gong, Chang-Sheng Dong, Yu-Zhou Du
The polyphagous agromyzid fly, Liriomyza trifolii, is a significant and important insect pest of ornamental and vegetable crops worldwide. The adaptation of insects to different environments is facilitated by heat shock proteins (HSPs), which play an important role in acclimation to thermal stress. In this study, we cloned and characterized five HSP-encoding genes of L. trifolii (Lthsp20, Lthsp40, Lthsp60, Lthsp70, and Lthsp90) and monitored their expression under different thermal stresses using real-time quantitative PCR...
2017: PloS One
https://www.readbyqxmd.com/read/28725639/anaplasma-phagocytophilum-msp4-and-hsp70-proteins-are-involved-in-interactions-with-host-cells-during-pathogen-infection
#10
Marinela Contreras, Pilar Alberdi, Lourdes Mateos-Hernández, Isabel G Fernández de Mera, Ana L García-Pérez, Marie Vancová, Margarita Villar, Nieves Ayllón, Alejandro Cabezas-Cruz, James J Valdés, Snorre Stuen, Christian Gortazar, José de la Fuente
Anaplasma phagocytophilum transmembrane and surface proteins play a role during infection and multiplication in host neutrophils and tick vector cells. Recently, A. phagocytophilum Major surface protein 4 (MSP4) and Heat shock protein 70 (HSP70) were shown to be localized on the bacterial membrane, with a possible role during pathogen infection in ticks. In this study, we hypothesized that A. phagocytophilum MSP4 and HSP70 have similar functions in tick-pathogen and host-pathogen interactions. To address this hypothesis, herein we characterized the role of these bacterial proteins in interaction and infection of vertebrate host cells...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28724629/abrogation-of-heat-shock-factor-1-hsf1-phosphorylation-deregulates-its-activity-and-lowers-activation-threshold-leading-to-obesity-in-mice
#11
Xiongjie Jin, Aijun Qiao, Demetrius Moskophidis, Nahid F Mivechi
Heat shock factor 1 (Hsf1) is transcriptionally activated following exposure of mammalian cells to environmental insults and pathological conditions. The function of Hsf1 as a protector of cells and organisms towards a range of stress stimuli has been well-documented. However, how different Hsf1 post-transcriptional modifications affect its function in vivo is not understood. Hsf1 transcriptional activity is in part regulated by phosphorylation. Hsf1 phosphorylation of amino acid residues at S303 and S307 has been shown to repress Hsf1 transcriptional activity under normal physiological growth conditions...
July 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28723944/application-of-mass-spectrometry-to-elucidate-the-pathophysiology-of-encephalitozoon-cuniculi-infection-in-rabbits
#12
Guillaume Desoubeaux, Maria Del Carmen Piqueras, Ana Pantin, Sanjoy K Bhattacharya, Roman Peschke, Anja Joachim, Carolyn Cray
Encephalitozoon cuniculi is a microsporidian species which can induce subclinical to serious disease in mammals including rabbits, a definitive natural host. The pathophysiology of infection has not been comprehensively elucidated. In this exploratory study, we utilized two mass spectrometry approaches: first, the analysis of the humoral response by profiling the microsporidian antigens as revealed by Western blot screening, and second, implementing the iTRAQ®-labeling protocol to focus on the changes within the host proteome during infection...
2017: PloS One
https://www.readbyqxmd.com/read/28723223/free-energy-of-binding-and-mechanism-of-interaction-for-the-meevd-tpr2a-peptide-protein-complex
#13
Mauro Lapelosa
The association between the MEEVD C-terminal peptide from the heat shock protein 90 (Hsp90) and tetratricopeptide repeat A (TPR2A) domain of the heat shock organizing protein (Hop) is a useful prototype to study the fundamental molecular details about the Hop-Hsp90 interaction. We study here the mechanism of binding/unbinding, and compute the standard binding free energy and potential of mean force for the association of the MEEVD peptide to the TPR2A domain using the Adaptive Biasing Force (ABF) methodology...
July 19, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28721857/stress-adaptation
#14
Alistair J P Brown, Leah E Cowen, Antonio di Pietro, Janet Quinn
Fungal species display an extraordinarily diverse range of lifestyles. Nevertheless, the survival of each species depends on its ability to sense and respond to changes in its natural environment. Environmental changes such as fluctuations in temperature, water balance or pH, or exposure to chemical insults such as reactive oxygen and nitrogen species exert stresses that perturb cellular homeostasis and cause molecular damage to the fungal cell. Consequently, fungi have evolved mechanisms to repair this damage, detoxify chemical insults, and restore cellular homeostasis...
July 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28721580/gene-expression-profiles-of-the-thermotolerant-yeast-saccharomyces-cerevisiae-strain-kku-vn8-during-high-temperature-ethanol-fermentation-using-sweet-sorghum-juice
#15
Atiya Techaparin, Pornthap Thanonkeo, Preekamol Klanrit
OBJECTIVES: To investigate gene expression profiles of the thermotolerant yeast Saccharomyces cerevisiae strain KKU-VN8, a potential high-ethanol producer, in response to various stresses during high-temperature ethanol fermentation using sweet sorghum juice (SSJ) under optimal conditions. RESULTS: The maximal ethanol concentration obtained by S. cerevisiae KKU-VN8 using SSJ at 40 °C was 66.6 g/l, with a productivity of 1.39 g/l/h and a theoretical ethanol yield of 81%...
July 18, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28720498/rna-aptamers-targeted-for-human-%C3%AE-a-crystallin-do-not-bind-%C3%AE-b-crystallin-and-spare-the-%C3%AE-crystallin-domain
#16
Prabhat K Mallik, Hua Shi, Jayanti Pande
The molecular chaperones, α-crystallins, belong to the small heat shock protein (sHSP) family and prevent the aggregation and insolubilization of client proteins. Studies in vivo have shown that the chaperone activity of the α-crystallins is raised or lowered in various disease states. Therefore, the development of tools to control chaperone activity may provide avenues for therapeutic intervention, as well as enable a molecular understanding of chaperone function. The major human lens α-crystallins, αA- (HAA) and αB- (HAB), share 57% sequence identity and show similar activity towards some clients, but differing activities towards others...
July 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28720296/urinary-heat-shock-protein-72-as-a-biomarker-of-acute-kidney-injury-in-dogs
#17
Yaron Bruchim, Yochai Avital, Michal Horowitz, Michal Mazaki-Tovi, Itamar Aroch, Gilad Segev
Early recognition of acute kidney injury (AKI) is important, as therapy is potentially more efficacious if instituted early in the course of disease. Urinary heat shock protein-72 to urinary creatinine ratio (uHSP72/uCr) was assessed as a diagnostic and prognostic marker in AKI in dogs. Fifty-three dogs were enrolled in five groups: healthy controls (n=11), urinary tract infection (n=10), chronic kidney disease (CKD; n=11), AKI (n=13), and acute decompensating CKD (n=8). Urinary heat shock protein-72 to urinary creatinine ratio was highest in the AKI group (P<0...
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28719870/effects-of-endocrine-disrupting-chemicals-on-estrogen-receptor-alpha-and-heat-shock-protein-60-gene-expression-in-primary-cultures-of-loggerhead-sea-turtle-caretta-caretta-erythrocytes
#18
Paolo Cocci, Martina Capriotti, Gilberto Mosconi, Francesco Alessandro Palermo
The loggerhead turtle (Caretta caretta) can be considered a good indicator species for studying the ecological impact of endocrine disrupting chemicals (EDCs) on wildlife. However, the effect of these environmental pollutants on nuclear steroid hormone signaling has not yet been addressed in sea turtles mainly due to the legal constraints of their endangered status. Here we describe the use of primary erythrocyte cell cultures as in vitro models for evaluating the effects of different EDCs on the expression of estrogen receptor α (ERα)...
July 15, 2017: Environmental Research
https://www.readbyqxmd.com/read/28718351/exosomal-hsp60-a-potentially-useful-biomarker-for-diagnosis-assessing-prognosis-and-monitoring-response-to-treatment
#19
Caruso Bavisotto, F Cappello, Ajl Macario, E Conway de Macario, M Logozzi, S Fais, C Campanella
Cell-to-cell communication is imperative for life and it is mediated by sending and receiving information via the secretion and subsequent receptor-mediated detection of biological molecules. Exosomes (EXs) secreted from cells to the extracellular environment play an important role in intercellular communication in normal and pathological conditions. Areas covered: New evidence indicates that tumor cells-derived EXs contribute to cancer progression through the modulation of tumor microenvironment. The exosomal heat shock protein 60 (HSP60) is very likely a key player in intercellular cross-talk, particularly during the progress of diseases, such as cancer...
July 18, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28717943/a-pyrrole-based-natural-small-molecule-mitigates-hsp90-expression-in-mda-mb-231-cells-and-inhibits-tumor-angiogenesis-in-mice-by-inactivating-hsf-1
#20
K C Rashmi, H S Atreya, M Harsha Raj, Bharathi P Salimath, H S Aparna
Heat shock proteins (HSPs), molecular chaperones, are crucial for the cancer cells to facilitate proper functioning of various oncoproteins involved in cell survival, proliferation, migration, and tumor angiogenesis. Tumor cells are said to be "addicted" to HSPs. HSPs are overexpressed in many cancers due to upregulation of transcription factor Heat-shock factor 1 (HSF-1), the multifaceted master regulator of heat shock response. Therefore, pharmacological targeting of HSPs via HSF-1 is an effective strategy to treat malignant cancers like triple negative breast cancer...
July 17, 2017: Cell Stress & Chaperones
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