keyword
Keywords Eosinophilic esophagitis in ch...

Eosinophilic esophagitis in children

https://read.qxmd.com/read/38093315/psychometric-evaluation-of-the-spanish-version-of-the-pediatric-quality-of-life-eosinophilic-esophagitis-questionnaire-peds-ql-eoe-module-%C3%A2
#21
MULTICENTER STUDY
Ruth Garcia-Martinez de Bartolomé, Josefa Barrio-Torres, MLuz Cilleruelo-Pascual, Juan José Rodríguez-Soler, Ángel Gil-de Miguel, Tomás Sebastián-Viana
BACKGROUND: The Paediatric Eosinophilic Oesophagitis Module (PedsQL-EoE) was developed in English as a valid and reliable questionnaire to assess health-related quality of life (HRQoL) in children with EoE. The aim of this study was to evaluate the validity and reliability of the PedsQL-EoE that was previously adapted to Spanish by our group. METHODS: This cross-sectional multicentre study was conducted in 36 paediatric gastroenterology units. Groups with and without dietary restrictions were studied separately...
December 13, 2023: Health and Quality of Life Outcomes
https://read.qxmd.com/read/38031952/is-the-pediatric-eosinophilic-esophagitis-symptom-score-v2-0-reliable-for-telemedicine
#22
JOURNAL ARTICLE
Sinem Polat Terece, Dilek Yapar, Hacer İlbilge Ertoy Karagöl, Gizem Köken, Demet Teker Düztaş, Ödül Eğritaş, Sinan Sari, Buket Dalgiç, Arzu Bakirtaş
BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease. Telemedicine is a healthcare technology used when a patient is separated by distance. The reliability of the Pediatric Eosinophilic Esophagitis Symptom Score, version 2.0 (PEESS v2.0) for telemedicine applications, has not been studied yet. Therefore, we aimed to evaluate the reliability of PEESS v2.0 for telemedicine. METHODS: We sent a telesurvey using questionnaires via electronic telecommunication as the telemedicine method...
August 2023: Turkish Journal of Medical Sciences
https://read.qxmd.com/read/37998581/the-usefulness-of-the-eosinophilic-esophagitis-histology-scoring-system-in-predicting-response-to-proton-pump-inhibitor-monotherapy-in-children-with-eosinophilic-esophagitis
#23
JOURNAL ARTICLE
Jovan Jevtić, Nina Ristić, Vedrana Pavlović, Jovana Svorcan, Ivan Milovanovich, Milica Radusinović, Nevena Popovac, Ljubica Simić, Aleksandar Ćirović, Miloš Đuknić, Maja Životić, Nevena Poljašević, Danilo Obradović, Jelena Filipović, Radmila Janković
BACKGROUND: Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease with rising incidence. While proton pump inhibitors (PPIs) are the first-line treatment, a significant proportion of patients do not respond. This study aimed to determine if the EoE Histology Scoring System (EoEHSS) can predict PPI responsiveness. METHODS: A cross-sectional study was conducted on 89 pediatric patients diagnosed with EoE between 2016 and 2022. Patients were categorized into PPI responders (PPIREoE) and non-responders (PPINREoE) based on post-treatment biopsies...
November 15, 2023: Diagnostics
https://read.qxmd.com/read/37968556/increasing-age-at-the-time-of-diagnosis-and-evolving-phenotypes-of-eosinophilic-esophagitis-over-20%C3%A2-years
#24
JOURNAL ARTICLE
Akshatha Kiran, Brenderia A Cameron, Zeyun Xue, Sean LaFata, Adolfo A Ocampo, Justin McCallen, Christopher J Lee, Stephanie A Borinsky, Walker D Redd, Cary C Cotton, Swathi Eluri, Craig C Reed, Evan S Dellon
BACKGROUND: The presentation of eosinophilic esophagitis (EoE) is heterogeneous, but trends over time are not known. AIM: To determine whether clinical and endoscopic phenotypes at EoE diagnosis have changed over the past 2 decades. METHODS: In this retrospective cohort study, adults and children with newly diagnosed EoE were phenotyped as follows: (1) inflammatory vs fibrostenotic vs mixed on endoscopy; (2) atopic vs non-atopic; (3) age at symptom onset; (4) age at diagnosis; (5) presence of autoimmune or connective tissue disease; and (6) responsive to steroids...
November 15, 2023: Digestive Diseases and Sciences
https://read.qxmd.com/read/37956499/factors-associated-with-eosinophilic-esophagitis-in-an-urban-tertiary-care-pediatric-aerodigestive-population-undergoing-triple-endoscopy
#25
JOURNAL ARTICLE
Sheila Moran, Cassidy Anderson, Risha Sheni, Monica Azmy, Daniel T Li, Anthony M Loizides, Christina J Yang
BACKGROUND: Children with aerodigestive dysfunction often undergo triple endoscopy (flexible bronchoscopy, rigid direct laryngoscopy and bronchoscopy, and esophagogastroduodenoscopy) for diagnostic evaluation as well as screening prior to airway reconstruction. Prevalence and risk factors for eosinophilic esophagitis (EoE) in this population are poorly understood. METHODS: A retrospective chart review was performed for pediatric patients, aged 0-21 years, who received a triple endoscopy with biopsy from January 1, 2015, to December 31, 2019, at the Children's Hospital at Montefiore (CHAM)...
November 5, 2023: American Journal of Otolaryngology
https://read.qxmd.com/read/37906323/qualitative-assessment-of-the-suitability-of-the-dysphagia-symptom-questionnaire-to-monitor-dysphagia-in-children-aged-7-10%C3%A2-years-with-eosinophilic-esophagitis
#26
JOURNAL ARTICLE
Robin M Pokrzywinski, Bridgett Goodwin, Evan S Dellon, Ellyn Kodroff, Anne Brooks, Adam Bailey, James Williams, Nirav K Desai
BACKGROUND: The Dysphagia Symptom Questionnaire (DSQ) is a patient-reported outcome measure that assesses the frequency and severity of dysphagia in patients with eosinophilic esophagitis (EoE); however, it has only been validated for use in patients with EoE aged 11-40 years. This study examined the content validity of the DSQ and its usability on an electronic handheld device in children aged 7-10 years with EoE. METHODS: In this qualitative, observational cohort study, participants were recruited to partake in two rounds of interviews...
October 31, 2023: Journal of Patient-Reported Outcomes
https://read.qxmd.com/read/37902735/maternal-and-infant-antibiotic-and-acid-suppressant-use-and-risk-of-eosinophilic-esophagitis
#27
JOURNAL ARTICLE
Elizabeth T Jensen, Helene M Svane, Rune Erichsen, Gencer Kurt, Uffe Heide-Jorgensen, Henrik T Sorensen, Evan S Dellon
IMPORTANCE: Eosinophilic esophagitis (EoE), a chronic disease with significant patient and health care burden, has increased rapidly in incidence across many countries. Elucidating risk factors for disease development is a priority for health care practitioners and patients. OBJECTIVE: To evaluate the association of maternal and infant use of antibiotics and acid suppressants with the development of EoE. DESIGN, SETTING, AND PARTICIPANTS: This was a population-based, case-control study of pediatric EoE (1996-2019) in Denmark using pathology, prescription, birth, inpatient, and outpatient health registry data and with complete ascertainment of all EoE cases among Danish residents born between 1997 and 2018...
December 1, 2023: JAMA Pediatrics
https://read.qxmd.com/read/37901762/unique-allergen-specific-human-ige-monoclonal-antibodies-derived-from-patients-with-allergic-disease
#28
JOURNAL ARTICLE
Bryan R E Smith, Kristina Reid Black, Max Bermingham, Sayeh Agah, Jill Glesner, Serge A Versteeg, Ronald van Ree, Glorismer Pena-Amelunxen, Lorenz Aglas, Scott A Smith, Anna Pomés, Martin D Chapman
INTRODUCTION: Allergic reactions are mediated by human IgE antibodies that bind to and cross-link allergen molecules. The sites on allergens that are recognized by IgE antibodies have been difficult to investigate because of the paucity of IgE antibodies in a human serum. Here, we report the production of unique human IgE monoclonal antibodies to major inhaled allergens and food allergens that can be produced at scale in perpetuity. MATERIALS AND METHODS: The IgE antibodies were derived from peripheral blood mononuclear cells of symptomatic allergic patients, mostly children aged 3-18 years, using hybridoma fusion technology...
2023: Front Allergy
https://read.qxmd.com/read/37892285/a-practical-update-on-pediatric-eosinophilic-esophagitis
#29
REVIEW
Martina Votto, Maria De Filippo, Silvia Caimmi, Cristiana Indolfi, Alessandro Raffaele, Maria Angela Tosca, Gian Luigi Marseglia, Amelia Licari
Eosinophilic esophagitis (EoE) is an emerging atopic disease of unknown etiology limited to the esophagus. The pathogenesis is still understood and is likely characterized by type 2 inflammation. Food allergens are the primary triggers of EoE that stimulate inflammatory cells through an impaired esophageal barrier. In children and adolescents, clinical presentation varies with age and mainly includes food refusal, recurrent vomiting, failure to thrive, abdominal/epigastric pain, dysphagia, and food impaction...
September 28, 2023: Children
https://read.qxmd.com/read/37870118/eosinophilic-esophagitis-does-age-matter
#30
REVIEW
Sara Massironi, Alessandra Elvevi, Roberto Panceri, Giacomo Mulinacci, Giacomo Colella, Andrea Biondi, Pietro Invernizzi, Silvio Danese, Edoardo Vespa
INTRODUCTION: Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus with increasing prevalence worldwide. It is a multifactorial disease caused by a combination of immunologic, genetic, and environmental factors. The clinical presentation of EoE varies largely, especially between different age groups. While diagnostic criteria and therapeutic goals are similar in children and adults, there are differences in treatment, with a more cautious approach in children to avoid growth disturbances...
October 23, 2023: Expert Review of Clinical Immunology
https://read.qxmd.com/read/37852329/a-synthesis-and-subgroup-analysis-of-the-eosinophilic-esophagitis-tissue-transcriptome
#31
JOURNAL ARTICLE
Justin Jacobse, Rachel Brown, Frank Revetta, Michael Vaezi, Matthew A Buendia, Christopher S Williams, Tina Higginbotham, M Kay Washington, Jeremy Goettel, Girish Hiremath, Yash A Choksi
BACKGROUND: We synthesized published and unpublished esophageal bulk RNA sequencing (RNA-seq) data to gain novel insights into the pathobiology of eosinophilic esophagitis (EoE) and examine the differences in EoE transcriptome by sex and age group. METHODS: Esophageal bulk RNA-seq data from 5 published and 2 unpublished studies resulting in 137 subjects (EoE: N=76 and controls: N=61) were analyzed. For overall analysis, combined RNA-seq data of EoE patients were compared to controls and subgroup analysis was conducted in EoE patients by age of the patient [children (< 18 years) vs...
October 16, 2023: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/37750913/proton-pump-inhibitors-in-eosinophilic-esophagitis-eoe-related-to-oral-immunotherapy-is-it-as-effective-as-in-other-eoe
#32
JOURNAL ARTICLE
Tzippora Shalem, Daniel L Cohen, Na'ama Epstein-Rigbi, Arnon Elizur, Adi Eindor-Abarbanel, Efrat Broide, Vered Richter
UNLABELLED: Oral immunotherapy (OIT) may induce eosinophilic esophagitis (EoE). Proton pump inhibitors (PPIs) are an effective treatment for EoE. However, the effect of PPI treatment is not well established in patients with EoE induced by OIT. Our primary aim was to compare the clinical, endoscopic, and histological response rates to PPIs in children with EoE induced by OIT (EoE+OIT) versus EoE patients without OIT (EoE-OIT). The secondary aims are to describe the clinical and histological features of EoE+OIT...
September 26, 2023: European Journal of Pediatrics
https://read.qxmd.com/read/37743034/the-index-of-severity-for-eosinophilic-esophagitis-i-see-reflects-longitudinal-clinicopathologic-changes-in-children
#33
JOURNAL ARTICLE
Andrew Dickerson, Ayse Kolemen, Keeler Kime, Kira Chaiboonma, Ranjan Dohil, Glenn T Furuta, Evan S Dellon, Seema S Aceves
BACKGROUND AND AIMS: The Index of Severity for Eosinophilic Esophagitis (I-SEE) was recently developed. We aimed to understand I-SEE scores in a longitudinal pediatric cohort and to determine the relationship between I-SEE and clinical features in children. METHODS: We performed a retrospective analysis on a prospectively enrolled cohort of children at a single center who were treated as part of routine clinical care. I-SEE was calculated at the diagnostic and follow-up endoscopies over a mean of 6...
September 22, 2023: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/37701950/food-induced-immediate-response-of-the-esophagus-in-pediatric-eosinophilic-esophagitis
#34
JOURNAL ARTICLE
Gizem Koken, Hacer Ilbilge Ertoy Karagol, Sinem Polat Terece, Zeynep Cavdar, Kenan Cetin, Odul Egritas Gurkan, Sinan Sari, Buket Dalgic, Arzu Bakirtas
BACKGROUND: Food-induced immediate response of the esophagus (FIRE) is a new phenomenon that has been described in eosinophilic esophagitis (EoE) patients. It is suspected when unpleasant symptoms occur suddenly on contact of the triggering food with the esophageal surface and recur with repeated exposures. It can often be mistaken for pollen-food allergy syndrome (PFAS) and solid food dysphagia. Data on FIRE is limited to one survey study and case reports, and there are no screening studies conducted on either adults or children with EoE...
September 13, 2023: Allergy
https://read.qxmd.com/read/37697476/feeding-tube-placement-complications-and-treatment-responses-in-a-large-eosinophilic-esophagitis-patient-population
#35
JOURNAL ARTICLE
Stephanie A Borinsky, Brenderia A Cameron, Zeyun Xue, Sean LaFata, Akshatha Kiran, Adolfo A Ocampo, Justin McCallen, Christopher J Lee, Walker D Redd, Cary C Cotton, Swathi Eluri, Craig C Reed, Evan S Dellon
OBJECTIVES: Feeding tubes can provide a temporary or long-term solution for nutritional therapy. Little is known regarding the use of feeding tubes in patients with eosinophilic esophagitis (EoE). We sought to describe the characteristics and outcomes in EoE patients requiring tube feeding. METHODS: This was a retrospective cohort study of EoE patients at a large tertiary care health system. Demographics, clinical characteristics, and endoscopic findings were extracted from medical records, and patients who had a feeding tube were identified...
September 12, 2023: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/37671875/eosinophilic-esophagitis-as-a-side-effect-of-allergen-immunotherapy-protocol-for-a-systematic-review-and-meta-analysis
#36
REVIEW
C Pitsios, C M Rossi, I Terreehorst, E Heffler, M Votto, G N Konstantinou, A Alvarez-Perea, A Bakirtas, E Apostolidou, D Antolin-Amerigo, G K Nikolopoulos, O Pfaar, A Cianferoni
Background. Sensitization to food and airborne allergens is common in the majority of patients with eosinophilic esophagitis (EoE). Although there is not a direct cause-effect relationship of IgE-mediated allergy with the pathogenesis of EoE, there is a growing evidence that oral desensitization to food and sublingual immunotherapy (SLIT) may induce the development of EoE as an adverse effect. As part of the 'EoE and Allergen Immunotherapy (AIT)' Task Force funded by the European Academy of Allergy and Clinical Immunology (EAACI), a systematic approach will be followed to review the evidence from the published scientific literature on the development of EoE in children and adults under any type of AIT...
September 6, 2023: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/37550113/triple-endoscopy-and-recurrent-croup-in-children-a-single-aerodigestive-center-experience
#37
JOURNAL ARTICLE
Jennifer P Vu, Deepak Jagannath, David R Spielberg, Eric H Chiou, Kathleen E Hosek, Elton M Lambert
OBJECTIVE: To determine the utility of triple endoscopy (combined direct laryngoscopy, bronchoscopy (DLB), flexible bronchoscopy with bronchoalveolar lavage (FB + BAL), and esophagogastroduodenoscopy (EGD)) in the diagnosis and management of patients with recurrent croup (RC), and to identify predictors of endoscopic findings METHODS: A retrospective chart review was performed of pediatric patients (age <18 years) with RC evaluated by triple endoscopy at a tertiary care pediatric hospital from 2010 to 2021...
August 6, 2023: Auris, Nasus, Larynx
https://read.qxmd.com/read/37489286/patterns-in-the-development-of-pediatric-allergy
#38
JOURNAL ARTICLE
Stanislaw J Gabryszewski, Jesse Dudley, Di Shu, Jennifer A Faerber, Robert W Grundmeier, Alexander G Fiks, David A Hill
OBJECTIVES: Describe clinical and epidemiologic patterns of pediatric allergy using longitudinal electronic health records (EHRs) from a multistate consortium of US practices. METHODS: Using the multistate Comparative Effectiveness Research through Collaborative Electronic Reporting EHR database, we defined a cohort of 218 485 children (0-18 years) who were observed for ≥5 years between 1999 and 2020. Children with atopic dermatitis (AD), immunoglobulin E-mediated food allergy (IgE-FA), asthma, allergic rhinitis (AR), and eosinophilic esophagitis (EoE) were identified using a combination of diagnosis codes and medication prescriptions...
August 1, 2023: Pediatrics
https://read.qxmd.com/read/37470293/medical-treatment-of-eosinophilic-esophagitis
#39
REVIEW
James P Franciosi, Morris Gordon, Vassiliki Sinopoulou, Evan S Dellon, Sandeep K Gupta, Craig C Reed, Carolina Gutiérrez-Junquera, Rajitha D Venkatesh, Elizabeth A Erwin, Abdullah Egiz, Assem Elleithy, Edward B Mougey
BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic antigen-mediated eosinophilic inflammatory disease isolated to the esophagus. As a clinicopathologic disorder, a diagnosis of EoE requires a constellation of clinical symptoms of esophageal dysfunction and histologic findings (at least 15 eosinophils/high-powered microscope field (eos/hpf)). Current guidelines no longer require the failure of response to proton pump inhibitor medications to establish a diagnosis of EoE, but continue to suggest the exclusion of other etiologies of esophageal eosinophilia...
July 20, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37463709/eosinophilic-esophagitis
#40
REVIEW
Saad Alkhowaiter
Eosinophilic esophagitis (EoE) is an atopic disease in which eosinophils infiltrate the esophageal mucosa and may result in a variety of upper gastrointestinal symptoms. Chief among these are dysphagia, heartburn, and food bolus obstruction in adults whereas children often present with abdominal pain or vomiting. Eosinophilic esophagitis is a chronic condition that if not detected and left untreated could lead to the development of subepithelial fibrosis and esophageal stenosis. The diagnosis of EoE is confirmed in a patient presenting with characteristic EoE symptoms, classic signs on endoscopy, and biopsy results showing >15 eosinophils/hpf...
July 2023: Saudi Medical Journal
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