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Eosinophilic esophagitis in children

https://read.qxmd.com/read/38451662/accuracy-of-the-eosinophilic-esophagitis-endoscopic-reference-score-in-children
#1
JOURNAL ARTICLE
Luciana M Ribeiro, Mário C Vieira, Sabine K Truppel, Nelson A Rosário Filho
BACKGROUND: To assess the efficacy of applying the endoscopic reference score for EoE (EREFS) in children with symptoms of esophageal dysfunction naïve to proton pump inhibitor (PPI) therapy. METHODS: An observational cross-sectional study was conducted by reviewing reports and photographs of upper gastrointestinal endoscopies (UGE) and esophageal biopsies of patients with symptoms of esophageal dysfunction. Patients who were treated with PPI or had other conditions that may cause esophageal eosinophilia were excluded...
2024: Arquivos de Gastroenterologia
https://read.qxmd.com/read/38447548/pediatric-patients-with-eosinophilic-esophagitis-and-their-parents-identify-symptoms-as-the-most-important-treatment-outcome
#2
JOURNAL ARTICLE
Thea von Graffenried, Ekaterina Safroneeva, Christian Braegger, Jessica Ezri, Luca Garzoni, Alexa Giroud Rivier, Thomas Greuter, Henrik Köhler, Valerie A McLin, George Marx, Pascal Müller, Laetitia Marie Petit, Susanne Schibli, Christiane Sokollik, Michela Tempia-Caliera, Marcel Zwahlen, Alain M Schoepfer, Andreas Nydegger
INTRODUCTION: Given the lack of data, we aimed to explore which therapeutic endpoints pediatric patients with eosinophilic esophagitis (EoE) and their parents consider to be relevant. METHODS: We created an educational brochure on EoE and a questionnaire, both of which were content-validated by pediatric patients and parents. Validated documents were sent to 112 patients and parents. They ranked the importance (5 levels) of short (during next 3 months) and long-term (≥1 year) treatment effect on symptoms, quality of life, endoscopic inflammation, stricture formation, histological inflammation, and fibrosis...
March 6, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38409891/proton-pump-inhibitors-antibiotics-and-atopy-increase-the-risk-of-eosinophilic-esophagitis-in-children-with-esophageal-atresia
#3
JOURNAL ARTICLE
Tiffany C Tang, Steven T Leach, Usha Krishnan
OBJECTIVE: To determine whether proton pump inhibitor (PPI) exposure is associated with an increased risk of developing eosinophilic esophagitis (EoE) in children with esophageal atresia (EA). STUDY DESIGN: A retrospective chart review of children with EA from January 1, 2005 to December 31, 2020 was undertaken at Sydney Children's Hospital Randwick. Children with EA and EoE (cases) were matched (1:2) to children with only EA (controls) to compare PPI exposure...
February 26, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38374566/granzyme-b-is-elevated-in-esophageal-biopsies-from-children-with-eosinophilic-esophagitis
#4
JOURNAL ARTICLE
Helena Thulin, Jesper Säfholm, Joachim Lundahl, Viktor Jovic, Mikael Adner, Caroline Nilsson
OBJECTIVES: Eosinophilic esophagitis (EoE) is an immune-mediated antigen-triggered inflammatory disease of the esophagus. Our aim was to investigate inflammatory responses by an ex vivo biopsy provocation-based method, stimulating biopsies with milk, wheat, and egg extracts. METHODS: An experimental study was conducted on esophageal biopsies from children who underwent esophagogastroduodenoscopy. Supernatants were collected before and after stimulation of the biopsies with food extracts and analyzed for 45 different inflammatory markers...
February 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38374551/addressing-diagnostic-dilemmas-in-eosinophilic-esophagitis-using-esophageal-epithelial-eosinophil-derived-neurotoxin
#5
REVIEW
Jessina Thomas, Puanani Hopson, Chirajyoti Deb, Jeffrey Bornstein, Devendra Mehta, Khaled Bittar, Yamen Smadi
OBJECTIVES: Eosinophil-derived neurotoxin (EDN) is a viable marker of eosinophilic esophagitis (EoE) disease activity. We studied the utility of measuring EDN from esophageal epithelial brushings for diagnosing EoE, focusing on two scenarios: (1) cases of exclusive distal eosinophilia and (2) cases of discrepancy between endoscopy and histology. METHODS: Records of patients who underwent esophagogastroduodenoscopy (EGD) with EDN measured via esophageal brushings at Arnold Palmer Hospital for Children in Orlando, Florida from January 2014 to October 2018 were retrospectively reviewed...
February 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38328342/identification-of-cxc-chemokine-receptor-2-cxcr2-as-a-novel-eosinophils-independent-diagnostic-biomarker-of-pediatric-eosinophilic-esophagitis-by-integrated-bioinformatic-and-machine-learning-analysis
#6
JOURNAL ARTICLE
Junhao Wu, Caihan Duan, Chaoqun Han, Xiaohua Hou
BACKGROUND: Eosinophilic esophagitis (EoE) is a complex allergic condition frequently accompanied by various atopic comorbidities in children, which significantly affects their life qualities. Therefore, this study aimed to evaluate pivotal molecular markers that may facilitate the diagnosis of EoE in pediatric patients. METHODS: Three available EoE-associated gene expression datasets in children: GSE184182, GSE 197702, GSE55794, along with GSE173895 were downloaded from the GEO database...
2024: ImmunoTargets and Therapy
https://read.qxmd.com/read/38314865/major-basic-protein-is-a-useful-marker-to-distinguish-eosinophilic-esophagitis-from-ibd-associated-eosinophilia-in-children
#7
JOURNAL ARTICLE
Samantha Butzke, Shaida Nasiri-Blomgren, Diana Corao-Uribe, Zhaoping He, Zarela Molle-Rios
OBJECTIVES: The incidence of eosinophilic esophagitis (EoE) is 3-5 times greater in patients with inflammatory bowel disease (IBD) compared with the general population. This study aimed to differentiate true EoE from esophageal eosinophilia in IBD patients by evaluating expression of major basic protein (MBP) and interleukin-13 (IL-13) in esophageal biopsies. METHODS: This retrospective study included subjects who had an esophagogastroduodenoscopy with esophageal biopsies for IBD work up or suspicion for EoE...
February 5, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38291684/joint-espghan-naspghan-guidelines-on-childhood-eosinophilic-gastrointestinal-disorders-beyond-eosinophilic-esophagitis
#8
JOURNAL ARTICLE
Alexandra Papadopoulou, Jorge Amil-Dias, Marcus Karl-Heinz Auth, Mirna Chehade, Margaret H Collins, Sandeep K Gupta, Carolina Gutiérrez-Junquera, Rok Orel, Mario C Vieira, Noam Zevit, Dan Atkins, Albert J Bredenoord, Fatima Carneiro, Evan S Dellon, Nirmala Gonsalves, Calies Menard-Katcher, Sibylle Koletzko, Chris Liacouras, Luba Marderfeld, Salvatore Oliva, Yoshikazu Ohtsuka, Marc E Rothenberg, Alex Strauman, Nikhil Thapar, Guan-Yu Yang, Glenn T Furuta
INTRODUCTION: Eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis (non-EoE EGIDs) are rare chronic inflammatory disorders of the gastrointestinal (GI) tract. Diagnosis is based on clinical symptoms and histologic findings of eosinophilic inflammation after exclusion of a secondary cause or systemic disease. Currently, no guidelines exist for the evaluation of non-EoE EGIDs. Therefore, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) formed a task force group to provide consensus guidelines for childhood non-EoE EGIDs...
January 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38290801/single-food-elimination-of-cow-s-milk-as-a-treatment-for-eosinophilic-esophagitis-in-children-aged-2-18-years-a-review-of-the-literature
#9
JOURNAL ARTICLE
Julianna Grasso, Diane Rigassio Radler, Rena Zelig
Cow's milk elimination (CME) is an established treatment, similar to other forms of diet therapy, for eosinophilic esophagitis (EoE). However, there is limited research to support its efficacy as a primary treatment. This review evaluated studies published in the past 10 years that assessed the outcomes after CME on histologic remission, clinical findings, and quality of life (QoL) in children aged 2-18 years with EoE. The evidence demonstrated that CME was effective at achieving histologic remission of disease in 50%-65% of children...
January 30, 2024: Nutrition in Clinical Practice
https://read.qxmd.com/read/38284339/fish-allergy-and-related-conditions-in-children-a-review
#10
REVIEW
Arianna Giannetti, Irene Bettini, Eleonora Alfieri, Amina De Bona, Giuliana Giannì, Giampaolo Ricci, Carlo Caffarelli
Fish allergy is the important food allergies in childhood, often persisting into adulthood. It can cause severe hypersensitivity reactions, including fatal anaphylaxis; furthermore, avoiding-fish diet has negative nutritional and psychological effects. Recent research studies focus on epitope structures and aim to develop sensitive and specific diagnostic tools, which have a better correlation with clinical reactions. Protocols with hypoallergenic parvalbumin or other recombinant antigens are also under study and will likely lead to new immunotherapy protocols...
2024: Current Pediatric Reviews
https://read.qxmd.com/read/38268956/eosinophilic-esophagitis-in-children-a-cross-sectional-study-from-a-tertiary-care-center
#11
JOURNAL ARTICLE
Arghya Samanta, Ujjal Poddar, Niraj Kumari, Moinak Sen Sarma, Anshu Srivastava, Prabhakar Mishra
BACKGROUND AND AIM: The prevalence of eosinophilic esophagitis (EoE) is rising in the West. However, data from the Indian subcontinent is limited. In this prospective cross-sectional study, we estimated the prevalence of EoE among children undergoing elective upper gastrointestinal endoscopy (UGIE). METHODS: We enrolled 200 consecutive children (123 boys, median age 10.25 years [interquartile range 8.25-14.5]) between March 2020 and November 2022 at our center...
January 2024: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38262705/eosinophilic-esophagitis-in-children-multicenter-retrospective-study-in-an-italian-cohort
#12
JOURNAL ARTICLE
Simona Barni, Benedetta Pessina, Luca Scarallo, Sara Renzo, Elena Sofia Pieri, Flavio Labriola, Patrizia Alvisi, Vincenzo Villanacci, Mattia Giovannini, Lucrezia Sarti, Leonardo Tomei, Jacopo Barp, Sara Naldini, Monica Paci, Francesca Mori, Paolo Lionetti
No abstract text is available yet for this article.
January 23, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38234411/prevalence-of-esophageal-eosinophilia-eosinophilic-esophagitis-and-lymphocytic-gastritis-in-children-with-celiac-disease-a-saudi-tertiary-center-experience
#13
JOURNAL ARTICLE
Meshari A Alaifan, Ammar Khayat, Rana Y Bokhary, Abdulhameed Ibrahim, Yagoub Bin-Taleb, Bakr H Alhussaini, Omar I Saadah
BACKGROUND: Celiac disease (CD) is an immune-mediated enteropathy that has been associated with other immune-related gastrointestinal disorders, such as eosinophilic esophagitis (EoE) and lymphocytic gastritis (LG). To our knowledge, this is the first study in Saudi Arabia that has described such an association. AIM: To evaluate the prevalence of EoE and LG in children and adolescents with CD. METHODS: This was a retrospective cross-sectional study of all pediatric patients (aged 0-18 years) with CD following up at King Abdulaziz University Hospital, between January, 2014, and December, 2021...
2024: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38214821/epidemiology-and-the-growing-epidemic-of-food-allergy-in-children-and-adults-across-the-globe
#14
REVIEW
Christopher M Warren, Shruti Sehgal, Scott H Sicherer, Ruchi S Gupta
PURPOSE OF REVIEW: Food allergies are immune-mediated, complex disorders, which are the source of increasing health concern worldwide. The goal of this review is to present an updated summary of the food allergy (FA) burden among children and adults across different populations, focusing on research from the past 5 years. RECENT FINDINGS: FAs impact a growing number of global residents-particularly those residing in higher-income, industrialized regions. Moreover, growing epidemiologic evidence suggests that the population health burden of non-IgE-mediated FAs, such as food protein-induced enterocolitis syndrome, may also be higher than previously reported...
January 12, 2024: Current Allergy and Asthma Reports
https://read.qxmd.com/read/38191332/there-is-a-long-way-from-current-clinical-practice-in-denmark-compared-to-recent-published-english-guideline-on-management-of-children-with-eosinophilic-oesophagitis
#15
JOURNAL ARTICLE
Kasper Bredal, Line Tegtmeier Frandsen, Jacob Holmen Terkelsen, Martin Hollænder Nielsen, Dorte Melgaard, Anne Lund Krarup
BACKGROUND: A low incidence of eosinophilic esophagitis (EoE) in children in the North Denmark Region (NDR) were measured in 2007-2017. Few of the children diagnosed before 2017 were treated to remission suggesting a lack of awareness. While there currently are no guidelines for treating EoE in Denmark, a new English guideline was published in 2022 renewing focus on the disease. OBJECTIVE: The aim of this study was to measure the difference of current Danish clinical practice for treatment and follow-up of EoE children in the NDR with the new English guideline from the British Society of Gastroenterology (BSG) and the British Society of Pediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN)...
January 8, 2024: BMC Pediatrics
https://read.qxmd.com/read/38154664/persistent-esophageal-changes-after-histologic-remission-in-eosinophilic-esophagitis
#16
JOURNAL ARTICLE
Melanie A Ruffner, Tetsuo Shoda, Megha Lal, Zoe Mrozek, Amanda B Muir, Jonathan M Spergel, Evan S Dellon, Marc E Rothenberg
BACKGROUND: Eosinophilic esophagitis (EoE) is characterized by persistent or relapsing allergic inflammation, and both clinical and histologic features of esophageal inflammation persist over time in most individuals. Mechanisms contributing to EoE relapse are not understood, and chronic EoE-directed therapy is therefore required to prevent long-term sequelae. OBJECTIVE: We investigated whether EoE patients in histologic remission have persistent dysregulation of esophageal gene expression...
December 27, 2023: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38129704/the-utility-of-balloon-based-and-standard-impedance-technology-to-diagnose-esophageal-mucosal-diseases-in-children
#17
JOURNAL ARTICLE
Rachel Rosen, Maritha Du, Anna Akkara, Andrea Catacora, Anna Wen, Enju Liu, Samuel Nurko
BACKGROUND: Standard impedance catheters and balloon-based mucosal impedance catheters (BBMI) have been used to assess mucosal integrity and diagnose mucosal diseases. The goal of this study was to determine the age-related technical issues associated with mucosal balloon inflation, validate the BBMI measurement against a standard impedance probe, and compare software-generated diagnoses to histologic diagnoses. METHODS: We prospectively recruited patients undergoing endoscopy, during which patients underwent standard mucosal impedance catheters and BBMI measurements...
December 21, 2023: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/38115912/pregnancy-outcomes-in-females-with-eosinophilic-esophagitis-a-nationwide-population-based-study
#18
JOURNAL ARTICLE
Lovisa Röjler, Amiko M Uchida, John J Garber, Olof Stephansson, Jonas Söderling, Bjorn Roelstraete, Jonas F Ludvigsson
INTRODUCTION: Eosinophilic esophagitis (EoE) is a chronic, allergic inflammatory disease of the esophagus. It has a peak incidence in the 2nd and 3rd decades of life. Despite this, little is known about pregnancy outcomes in patients with EoE. METHODS: Using a validated histopathologic and nationwide population-based cohort for the diagnosis of EoE, we examined maternal and fetal outcomes, with preterm birth as the primary outcome, in females with EoE compared to matched controls...
December 2023: Inflammatory Intestinal Diseases
https://read.qxmd.com/read/38112293/in-vivo-raman-spectroscopy-reveals-biochemical-composition-of-the-esophageal-tissue-in-pediatric-eosinophilic-esophagitis
#19
JOURNAL ARTICLE
Locke Andrea, Ezekiel Haugen, Thomas Giju, Correa Hernan, Dellon Evan S, Mahadevan-Jansen Anita, Hiremath Girish
BACKGROUND AND AIMS: Biochemical alterations in the esophagus of patients with eosinophilic esophagitis (EoE) is poorly understood. We used Raman spectroscopy via a pediatric endoscope to identify key Raman features reflective of the esophageal biochemical composition to differentiate between children with EoE from non-EoE controls, and between children with active (aEoE) and inactive EoE (iEoE). METHODS: Spectral measurements were obtained using a customized pediatric endoscope-compatible fiberoptic Raman probe in real-time during an esophagogastroduodenoscopy...
December 19, 2023: Clinical and Translational Gastroenterology
https://read.qxmd.com/read/38110118/barriers-to-timely-diagnosis-of-eosinophilic-gastrointestinal-diseases
#20
JOURNAL ARTICLE
Mirna Chehade, Emily C McGowan, Benjamin L Wright, Amanda B Muir, Amy D Klion, Glenn T Furuta, Elizabeth T Jensen, Dominique D Bailey
Although eosinophilic gastrointestinal diseases, including eosinophilic esophagitis, have been described over the past 2 to 3 decades, barriers to diagnosis and treatment are common and compounded by issues related to social determinants of health, race, ethnicity, and access to care. These barriers contribute to delays in diagnosis, resulting in persistent inflammation in the gastrointestinal tract, which can have significant consequences, including fibrostenotic complications in adults, failure to thrive in children, and decreased quality of life in all affected patients...
December 17, 2023: Journal of Allergy and Clinical Immunology in Practice
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