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Eosinophilic esophagitis in children

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https://www.readbyqxmd.com/read/28205735/p-38-risk-factors-for-eosinophilic-esophagitis-in-children-with-esophageal-atresia
#1
M A Marcon, V D Scaini, C M Forster, P P L Chiu, J C Langer, S D Dell
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205729/p-23-quality-of-life-in-children-with-eosinophilic-esophagitis-associated-with-esophageal-atresia-and-tracheoesophageal-fistula
#2
U K Krishnan, L M McLennan, J C Li Chan, C C Clarkson, J M Menzies, J H Hughes, M S Soma, V V Varjavandi, A J Jiwane, S A Adams, C W Wu, Y B Belessis
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205704/p-13-rates-of-allergic-sensitization-in-children-with-esophageal-atresia-and-eosinophilic-esophagitis
#3
H Wong-See, P Gray, U Krishnan
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205688/o-09-09-57-to-10-09-treatment-outcomes-for-eosinophilic-esophagitis-in-children-with-esophageal-atresia
#4
L Chan, F Briglia, C Clarkson, U K Krishnan
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28194801/differences-in-eosinophil-molecular-profiles-between-children-and-adults-with-eosinophilic-esophagitis
#5
Christine Lingblom, Timo Käppi, Henrik Bergquist, Mogens Bove, Rikard Arkel, Robert Saalman, Christine Wennerås
BACKGROUND: Eosinophilic esophagitis (EoE) afflicts both children and adults. It has been debated whether pediatric and adult EoE represent different disease entities. The objectives of this study were to determine if the blood eosinophil molecular pattern of children with EoE is: 1) distinct from that of healthy children; and 2) different from that of adults with EoE. METHODS: Blood eosinophils from children and adults with EoE, and healthy controls, were analyzed with flow cytometry regarding levels of CD23, CD44, CD54, CRTH2, FOXP3 and galectin-10...
February 14, 2017: Allergy
https://www.readbyqxmd.com/read/28118289/utility-of-gastric-and-duodenal-biopsies-during-follow-up-endoscopy-in-children-with-eosinophilic-esophagitis
#6
Sunpreet Kaur, John M Rosen, Alyssa A Kriegermeier, Joshua B Wechsler, Amir F Kagalwalla, Jeffrey B Brown
OBJECTIVES: Eosinophilic esophagitis (EoE) is a chronic antigen-mediated immune disorder of the esophagus. Consensus guidelines recommend obtaining esophageal, gastric and duodenal biopsies at diagnostic endoscopy when EoE is suspected. The utility of repeated gastric and duodenal biopsies during follow-up endoscopy in patients previously diagnosed with EoE is not established. The aim of this study was to explore the role of gastric and duodenal biopsies in children with an established diagnosis of EoE undergoing repeat endoscopy to assess histological response to treatment...
January 21, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28063681/is-fundoplication-required-after-the-foker-procedure-for-long-gap-esophageal-atresia
#7
Dylan Wanaguru, Catherine Langusch, Usha Krishnan, Vincent Varjavandi, Ashish Jiwane, Susan Adams, Guy Henry
BACKGROUND: Fundoplication has been performed almost universally in children treated with the Foker procedure (FP) for long gap esophageal atresia (LGEA). We report our experience with pharmacological management and endoscopic surveillance rather than early routine fundoplication in infants treated with the FP. METHODS: A retrospective chart review was performed of all children treated with the Foker procedure at our institution. RESULTS: Nine children have undergone the FP since 2007...
December 28, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28055990/dilation-of-pediatric-eosinophilic-esophagitis-adverse-events-and-short-term-outcomes
#8
Calies Menard-Katcher, Glenn T Furuta, Robert E Kramer
OBJECTIVES: Although several studies report the experience with adult eosinophilic esophagitis (EoE) related stricture, outcomes for pediatric patients with EoE associated fibrostenosis and stricture is even more limited. To address this, we aim to identify the adverse event rate and short-term outcomes of the largest reported cohort of children with EoE to undergo esophageal dilation for management of symptomatic esophageal narrowing. METHODS: A retrospective assessment of all children, 18 years and younger, who underwent esophageal dilation at an academic children's hospital over a 5-year period was conducted...
July 18, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28045773/the-association-between-celiac-disease-and-eosinophilic-esophagitis-mayo-experience-and-meta-analysis-of-the-literature
#9
Salim Hommeida, Mouaz Alsawas, Mohammad H Murad, David A Katzka, Rayna M Grothe, Imad Absah
BACKGROUND: The association between celiac disease (CD) and eosinophilic esophagitis (EoE) has been the focus of multiple studies with variable results. Both diseases are immune mediated, and dietary triggers play a role in their pathogenesis. OBJECTIVES: The aim of the study was to analyze the risk of EoE in children with CD, assess the magnitude of association between CD and EoE in children, and report the characteristics and outcomes of children with both conditions...
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28042003/the-prevalence-of-eosinophilic-esophagitis-in-pediatric-patients-with-ige-mediated-food-allergy
#10
David A Hill, Jesse W Dudley, Jonathan M Spergel
BACKGROUND: Eosinophilic esophagitis (EoE) is an allergic inflammatory disease that is triggered by food allergens and characterized by progressive esophageal dysfunction. Recently, EoE has been identified in patients who underwent oral immunotherapy (OIT) for IgE-mediated food allergy, suggesting an association. OBJECTIVE: We sought to ascertain whether significant associations exist between IgE-mediated food allergies and EoE. METHODS: Using the analysis of electronic medical record data and manual chart review, we examined our subspecialty care network of 35,528 children and adolescents to identify and characterize patients with IgE-mediated and EoE food allergy...
December 30, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27998193/update-on-dietary-therapy-for-eosinophilic-esophagitis-in-children-and-adults
#11
Javier Molina-Infante, Pedro Luis Gonzalez-Cordero, Angel Arias, Alfredo J Lucendo
Eosinophilic esophagitis (EoE) is a chronic inflammatory esophageal disease triggered predominantly, but not excusively, by food antigens. Elimination diet thus remains the only therapy targeting the cause of the disease. Importantly, EoE is a unique form of non-IgE mediated food allergy, largely dependant upon delayed, cell-mediated hypersensitivity. Areas covered: A comprehensive review of literature to summarize and update the most relevant advances on dietary therapy for pediatric and adult EoE patients is conducted...
February 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27984348/low-impedance-baseline-values-predict-severe-esophagitis
#12
Judith Cohen Sabban, Gabriela Donato Bertoldi, Federico Ussher, Silvia Christiansen, Carlos Lifschitz, Marina Orsi
OBJETIVES: To determine if esophageal baseline impedance (BI) values in children could be predictive of esophagitis. MATERIAL & METHODS: Multichannel intraluminal Impedance (MII) tracings of children 3 to 17 yrs of age suspected of having gastroesophageal reflux (GER) and esophagitis, who had also undergone upper endoscopy with multiple esophageal biopsies, were reviewed. Patients with eosinophilic esophagitis were excluded. Esophagitis was assessed by macroscopic and microscopic parameters...
December 15, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27922230/consensus-statement-on-diagnosis-treatment-and-follow-up-of-cow-s-milk-protein-allergy-among-infants-and-children-in-turkey
#13
Aydan Kansu, Aysel Yüce, Buket Dalgıç, Bülent Enis Şekerel, Fügen Çullu-Çokuğraş, Haluk Çokuğraş
The present paper aims to provide experts' consensus on diagnosis and management of cow's milk protein allergy (CMPA) among infants and children in Turkey, based on review of available evidence-based guidelines, publications and experts' clinical experience. The experts agreed that CMPA diagnosis should be based on symptomatic evaluation and diagnostic elimination diet as followed by implementation of an open challenge test after disappearance of symptoms and confirmation of CMPA diagnosis in re-appearance of symptoms...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27906799/diet-and-stress-in-pediatric-eosinophilic-esophagitis
#14
Christine Case, Glenn T Furuta, Dan Atkins, Zhaozing Pan, Jane Robinson
Clinical experiences and recent studies suggest that Eosinophilic Esophagitis (EoE) has the potential to induce caregiver (CG) and child stress. The specific sources of CG EoE-related stress remain uncertain. To address this, we performed a survey of CGs and youth attending an EoE patient education symposium that measured potential stressful elements in their daily life. Our results indicated that CGs experienced most stress associated with purchasing, preparation and completion of meals. We conclude that providers should consider this in choosing therapeutic approaches for children with EoE...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27900765/the-role-of-the-otolaryngologist-in-the-evaluation-and-diagnosis-of-eosinophilic-esophagitis
#15
Mark Kubik, Prasad Thottam, Amber Shaffer, Sukgi Choi
OBJECTIVE: To describe the clinical presentation and role of the otolaryngologist in the evaluation of eosinophilic esophagitis (EoE) at a tertiary pediatric hospital. STUDY DESIGN: Retrospective review. METHODS: Records from pediatric patients with a diagnosis of EoE from 2003 to 2015 were reviewed. Study variables were analyzed to compare patients presenting to different specialties. RESULTS: Two hundred and fifty-one patients with EoE were evaluated...
November 30, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27821174/eosinophilic-esophagitis-after-congenital-diaphragmatic-hernia
#16
Amelia Licari, Riccardo Castagnoli, Gian Luigi Marseglia
BACKGROUND: Eosinophilic esophagitis (EoE) is an increasingly diagnosed disease, especially in the western world. Although its pathogenesis remains poorly understood, there is strong evidence that the eosinophilic inflammation in EoE is primarily triggered by immune dysregulation secondary to allergic sensitization to dietary or aero-allergens. Recent studies have reported a higher prevalence of EoE in children with congenital gastrointestinal malformations, i.e. esophageal atresia and/or tracheoesophageal fistula...
November 8, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27766109/adrenal-suppression-in-children-treated-with-swallowed-fluticasone-and-oral-viscous-budesonide-for-eosinophilic-esophagitis
#17
Alexandra Ahmet, Eric I Benchimol, Ellen B Goldbloom, Janice L Barkey
BACKGROUND: Adrenal suppression (AS), a glucocorticoid (GC) side effect associated with significant morbidity, is well described related to inhaled corticosteroid therapy for asthma. Swallowed topical glucocorticoid therapy is the main pharmacotherapy treatment for eosinophilic esophagitis (EoE) and therefore children with EoE are potentially at increased risk of AS. METHODS: In this prospective cohort study, we included children and youth <18 years diagnosed with EoE and treated with swallowed fluticasone or oral viscous budesonide for more than 1 month...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27758725/-dysphagia-in-children
#18
E Ten Velde, B C Gonera-de Jong
In this case report we discuss two children with dysphagia. Both presented with difficulties in swallowing and oesophageal impaction of solid food. The first case involves a 16-year-old boy who suffered from dysphagia for many years. After a long diagnostic journey, during which a psychogenic cause was suspected, he was diagnosed with oesophageal achalasia. After a balloon dilatation of the lower oesophageal sphincter his complaints persisted and the treatment procedure was repeated. The second case involves a 15-year-old girl, who presented with a food impaction in the distal oesophagus...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27742702/trail-deficiency-and-pp2a-activation-with-salmeterol-ameliorates-egg-allergen-driven-eosinophilic-esophagitis
#19
Leon A Sokulsky, Adam M Collison, Scott Nightingale, Anna Le Fevre, Elizabeth Percival, Malcolm R Starkey, Philip M Hansbro, Paul S Foster, Joerg Mattes
Food antigens are common inflammatory triggers in pediatric eosinophilic esophagitis (EoE). TNF-related apoptosis-inducing ligand (TRAIL) promotes eosinophilic inflammation through the upregulation of the E3 ubiquitin ligase Midline (MID)-1 and subsequent downregulation of protein phosphatase 2A (PP2A), but the role of this pathway in EoE that is experimentally induced by repeated food antigen challenges has not been investigated. Esophageal mucosal biopsies were collected from children with EoE and controls and assessed for TRAIL and MID-1 protein and mRNA transcript levels...
December 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27741060/elevated-serum-tissue-transglutaminase-antibodies-in-children-with-eosinophilic-esophagitis
#20
Anna K Le Fevre, Marjorie M Walker, Amir Hadjiashrafy, Rani Bhatia, Joerg Mattes, Nicholas J Talley, Scott Nightingale
OBJECTIVES: This study compared the clinical and histopathological characteristics of children with EoE and elevated anti-transglutaminase (TTG Ab) with those with EoE and normal TTG Ab titres. METHODS: Single center chart and blinded histopathological review of patients diagnosed with EoE over a four-year period, who had esophageal and duodenal biopsies taken at time of endoscopy, and TTG Ab measured within 6 months of biopsy. Patients with histology-proven CD were excluded...
October 12, 2016: Journal of Pediatric Gastroenterology and Nutrition
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