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Meng Xu, Huamao Jaing, Haiguang Wang, Jiajie Liu, Baohao Liu, Zhongqiang Guo
The mechanisms of malignant cell metastasis to secondary sites are complex and multifactorial. Studies have demonstrated that small integrin‑binding ligand N‑linked glycoproteins (SIBLINGs), particularly bone sialoprotein (BSP) and osteopontin (OPN), are involved in neoplastic growth and metastasis. SIBLINGs promote malignant cell invasion and metastasis by enhancing matrix metalloproteinase 2 (MMP‑2) and MMP‑9 expression. Moreover, BSP and OPN can combine with integrin, which is located on the tumor cell surface, to further promote the malignant behavior of tumor cells...
June 18, 2018: Oncology Reports
T Filardi, V Carnevale, R Massoud, C Russo, L Nieddu, F Tavaglione, I Turinese, A Lenzi, E Romagnoli, S Morano
PURPOSE: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation. The aim of this study was to evaluate the association of OPN with fracture prevalence and with metabolic parameters in post-menopausal women with T2DM. METHODS: Sixty-four post-menopausal women with T2DM (age 67.0 ± 7.8 years, diabetes duration 8.9 ± 6.7 years), enrolled in a previous study, were followed up (3...
June 18, 2018: Journal of Endocrinological Investigation
Stephen Fitter, Andrew C W Zannettino
No abstract text is available yet for this article.
May 2018: Obesity Research & Clinical Practice
Sara Scutera, Valentina Salvi, Luisa Lorenzi, Giorgia Piersigilli, Silvia Lonardi, Daniela Alotto, Stefania Casarin, Carlotta Castagnoli, Erica Dander, Giovanna D'Amico, Silvano Sozzani, Tiziana Musso
Mesenchymal stromal cells (MSCs) exert immunosuppressive effects on immune cells including dendritic cells (DCs). However, many details of the bidirectional interaction of MSCs with DCs are still unsolved and information on key molecules by which DCs can modulate MSC functions is limited. Here, we report that osteopontin (OPN), a cytokine involved in homeostatic and pathophysiologic responses, is constitutively expressed by DCs and regulated in the DC/MSC cocultures depending on the activation state of MSCs...
2018: Frontiers in Immunology
Yu-Qiong He, Hua Yang, Yi Shen, Jian-Hua Zhang, Zhi-Guo Zhang, Lin-Lin Liu, Hong-Tao Song, Bin Lin, Hsien-Yeh Hsu, Lu-Ping Qin, Ting Han, Hai-Liang Xin, Qiao-Yan Zhang
Estrogen deficiency and inflammation are known to play important roles in bone metabolism and occurrence of osteoporosis. Monotropein as an iridoid glycoside is reported to decrease estrogen deficiency-induced bone loss and inhibit inflammatory response in LPS-induced RAW 264.7 macrophages. However, the effect of monotropein on bone loss in chronic inflammatory conditions remains unclear. It was found in the present study that monotropein significantly inhibited bone mass reduction and improved bone micro-architectures by enhancing bone formation and blocking increased secretion of inflammatory cytokines in osteoporotic mice induced by combined ovariectomy and LPS...
June 14, 2018: Chemico-biological Interactions
Jaqueline Suemi Hassumi, Gabriel Mulinari-Santos, André Luis da Silva Fabris, Ricardo Garcia Mureb Jacob, Alaíde Gonçalves, Ana Cláudia Rossi, Alexandre Rodrigues Freire, Leonardo Pérez Faverani, Roberta Okamoto
INTRODUCTION: Alveolar bone healing after upper incisor extraction in rats is a classical model of preclinical studies. The underlying morphometric, cellular and molecular mechanism, however, remains imprecise in a unique study. OBJECTIVES: The aim of this study was therefore to characterize the alveolar bone healing after upper incisor extraction in rats by micro computed tomographic (Micro-CT), immunohistochemical and real-time polymerase chain reaction (RT-PCR) analysis...
June 11, 2018: Journal of Applied Oral Science: Revista FOB
Hao Geng, Jiajun Qiu, Hongqin Zhu, Xuanyong Liu
Nitrogen doped graphene quantum dots (N-GQDs) were synthesized to explore and extend their potential applications in biomedical field. The hemocompatibility and cytotoxity of the obtained N-GQDs were primarily assessed at concentrations ranging from 10 to 100 μg/ml. From the results, it was found that the proliferation of rat Bone Mesenchymal Stem Cells (rBMSCs) was depressed to a certain extent after incubating with the high concentration (100 μg/ml) of N-GQDs. The nanoscale size and superior dispersibility endow N-GQDs with good cell permeability...
June 11, 2018: Journal of Materials Science. Materials in Medicine
Erxia Shen, Qin Wang, Hardis Rabe, Wenquan Liu, Harvey Cantor, Jianmei W Leavenworth
Lineage commitment and differentiation into CD4+ T cell subsets reflect an interplay between chromatin regulators and transcription factors (TF). Follicular T cell development is regulated by the Bcl6 TF, which helps determine the phenotype and follicular localization of both CD4+ follicular helper T cells (TFH ) and follicular regulatory T cells (TFR ). Here we show that Bcl6-dependent control of follicular T cells is mediated by a complex formed between Bcl6 and the Mi-2β-nucleosome-remodeling deacetylase complex (Mi-2β-NuRD)...
June 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
Jeneen Panezai, Ambereen Ghaffar, Mohammad Altamash, Per-Erik Engström, Anders Larsson
BACKGROUND: Periodontal disease (PD) and rheumatoid arthritis (RA) are bone pathologies mediated through immuno-inflammatory mechanisms. The aim of this study was to investigate the serum markers osteopontin (OPN), tumor necrosis factor receptors 1 (TNFR1) and 2 (TNFR2) receptor activator of nuclear factor-kappa B ligand (RANKL) and RANKL/ osteoprotegerin (OPG) ratio and compare them in PD and RA groups. MATERIALS & METHODS: RA (with PD = 19 and without PD = 19), PD (n = 38) and 14 healthy subjects underwent bleeding on probing (BOP) and probing pocket depth (PPD) measurement...
2018: PloS One
Qingxiang Zeng, Xi Luo, Miaomiao Han, Wenlong Liu, Huabin Li
The prevalence of allergic rhinitis (AR) and obesity in children increased concurrently during recent decades. However, the molecular pathway involved in the interaction between obesity and AR is still unclear. We aimed to investigate the interaction between leptin and osteopontin (OPN) and their effect on T helper (TH ) response in the development of AR in children. Thirty AR and 30 healthy children with or without obesity were enrolled. Serum leptin and OPN levels were measured and their relationship with TH 1/2 cytokines was analyzed...
June 6, 2018: EBioMedicine
Lei Gong, Anatol Manaenko, Ruiming Fan, Lei Huang, Budbazar Enkhjargal, DevinW McBride, Yan Ding, Jiping Tang, Xiaoqiu Xiao, John H Zhang
Acute intracerebral hemorrhage (ICH) complicated by hyperglycemia is associated with aggravation of post-stroke inflammation, leading to exacerbation of brain edema and predicting poor neurological outcomes and higher mortality of patients. Osteopontin (OPN) is a neuroprotective glycoprotein, which is able to attenuate brain injury induced by hemorrhagic stroke. In the current study we investigated whether OPN will decrease the inflammatory post-ICH response as well as attenuate brain edema and neurological deficits in hyperglycemic rats...
June 7, 2018: Neuropharmacology
Shuli Fan, Xiang Gao, Peng Chen, Xu Li
Myricetin has been reported to promote osteogenic differentiation and inhibit osteoclastogenesis. The aim of this study was to investigate the potential effects of myricetin on glucocorticoid-induced osteoporosis (GIOP) both in vivo and in vitro. Male Sprague-Dawley (SD) rats were given dexamethasone (DEX, 0.1 mg/kg, s.c.) once daily and myricetin (1 mg/kg or 2.5 mg/kg, i.p.) once every other day for a total of five weeks. Body weight was recorded once a week. Bone mineral density (BMD), the activities or levels of bone turnover markers, and histological changes were assessed...
June 5, 2018: Life Sciences
Nina N Harke, Philipp Mandel, Jorn H Witt, Christian Wagner, Andrej Panic, Anselm Boy, Alexander Roosen, Burkhard Ubrig, Andreas Schneller, Frank Schiefelbein, Nina Wagener, Patrick Honeck, Georg Schoen, Boris Hadaschik, Maurice S Michel, Maximilian C Kriegmair
BACKGROUND: To compare the outcomes of robot-assisted (RAPN) and open partial nephrectomy (OPN) for completely endophytic renal tumors. METHODS: Consecutive patients undergoing OPN or RAPN for entirely endophytic tumors in four high-volume centers between 2008 and 2016 were identified. Endophytic masses were identified based on sectional imaging. Patient characteristics and surgical outcome were compared using Mann-Whitney-U-test and chi-squared-tests. Uni- and multivariate analyses were performed to identify predictors of TRIFECTA achievement and excisional volume loss...
June 7, 2018: Journal of Surgical Oncology
Chun Wai Ng, Issan Yee San Tam, Sze Wing Sam, Yangyang Yu, Hang Yung Alaster Lau
Osteopontin (OPN) is an Arg-Gly-Asp (RGD)-containing extracellular matrix protein which is upregulated in inflamed tissues and has been reported to modulate mast cell activities in mice. Due to the known heterogeneity among mast cells of different species and the important roles of mast cells in allergic reactions, we investigated the effects of human OPN (hOPN) on human mast cell activities. Mature primary human cultured mast cells (HCMC) were derived from peripheral blood CD34+ progenitors and the modulation of their activation by soluble and plate-bound immobilized hOPN were examined by studying their release of inflammatory mediators (histamine, IL-5, IL-8, TNF-α, and VEGF) and matrix adhesion following stimulation by anti-IgE...
2018: Frontiers in Immunology
Z Feldbrin, E Omelchenko, A Lipkin, M Shargorodsky
BACKGROUND: The present study was designed to investigate the impact of osteopontin (OPN) in different tissue (e.g., plasma, muscles and bone) on amputation rate (in-hospital and during one year follow-up) for non-healing diabetic foot ulcers (DFUs). METHODS: This pilot study consisted of 30 diabetic patients, hospitalized due to non-healing DFUs. Patients were divided into two groups: Group 1 included 14 patients who underwent limb-preserved debridement procedure without amputation; Group 2 included 16 subjects who underwent amputation...
May 17, 2018: Journal of Diabetes and its Complications
Michal Izrael, Shalom Guy Slutsky, Tamar Admoni, Louisa Cohen, Avital Granit, Arik Hasson, Joseph Itskovitz-Eldor, Lena Krush Paker, Graciela Kuperstein, Neta Lavon, Shiran Yehezkel Ionescu, Leonardo Javier Solmesky, Rachel Zaguri, Alina Zhuravlev, Ella Volman, Judith Chebath, Michel Revel
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a motor neuron (MN) disease characterized by the loss of MNs in the central nervous system. As MNs die, patients progressively lose their ability to control voluntary movements, become paralyzed and eventually die from respiratory/deglutition failure. Despite the selective MN death in ALS, there is growing evidence that malfunctional astrocytes play a crucial role in disease progression. Thus, transplantation of healthy astrocytes may compensate for the diseased astrocytes...
June 6, 2018: Stem Cell Research & Therapy
Shubham Goel, Smrity Sahu, Ranjana W Minz, Surjit Singh, Deepti Suri, Young M Oh, Amit Rawat, Shobha Sehgal, Biman Saikia
Background: Hyper-IgE syndrome (HIES) caused by loss-of-function (LOF) mutations in STAT3 gene (STAT3 LOF HIES) is associated with dental and facial abnormalities in addition to immunological defects. The role of STAT3 in the pathogenesis of the dental/facial features is, however, poorly elucidated. Objectives: Since mechanism of cellular resorption of mineralized tissues such as bone and teeth are similar, we attempted to study the expression of genes involved in bone homeostasis in STAT3 LOF HIES...
2018: Frontiers in Immunology
Amira Raudhah Abdullah, Hermizi Hapidin, Hasmah Abdullah
Background. Quercus infectoria (QI) is a plant used in traditional medicines in Asia. The plant was reported to contain various active phytochemical compounds that have potential to stimulate bone formation. However, the precise mechanism of the stimulation effect of QI on osteoblast has not been elucidated. The present study was carried out to isolate QI semipurified fractions from aqueous QI extract and to delineate the molecular mechanism of QI semipurified fraction that enhanced bone formation by using hFOB1...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
F R Cirano, S P Pimentel, M Z Casati, M G Corrêa, D S Pino, M R Messora, P H F Silva, F V Ribeiro
This study determined the effect of curcumin on bone healing in animals with diabetes mellitus (DM). One hundred rats were divided into five groups: DM+PLAC, DM+CURC, DM+INS, DM+CURC+INS, and non-DM (CURC, curcumin; PLAC, placebo; INS, insulin). Critical calvarial defects were created and titanium implants were inserted into the tibiae. Calvarial defects were analyzed histometrically, and BMP-2, OPN, OPG, RANKL, Runx2, Osx, β-catenin, Lrp-5, and Dkk1 mRNA levels were quantified by PCR. The implants were removed for a torque evaluation, the peri-implant tissue was collected for mRNA quantification of the same bone-related markers, and the tibiae were submitted to micro-computed tomography...
May 29, 2018: International Journal of Oral and Maxillofacial Surgery
Ran Wei, Janet Pik Ching Wong, Peng Lyu, Xinping Xi, Olivia Tong, Shu-Dong Zhang, Hiu Fung Yuen, Senji Shirasawa, Hang Fai Kwok
Osteopontin (OPN) has been shown to promote colorectal cancer (CRC) progression; however, the mechanism of OPN-induced CRC progression is largely unknown. In this study, we found that OPN overexpression led to enhanced anchorage-independent growth, cell migration and invasion in KRAS gene mutant cells but to a lesser extent in KRAS wild-type cells. OPN overexpression also induced PI3K signalling, expression of Snail and Matrix metallopeptidase 9 (MMP9), and suppressed the expression of E-cadherin in KRAS mutant cells...
May 30, 2018: Journal of Cellular and Molecular Medicine
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