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tumor enviroment

Xiaotong Xue, Lihua Wang, Xianguang Meng, Jing Jiao, Ningning Dang
Melanoma is a tumor produced by skin melanocytes, which has a high metastatic rate and poor prognosis. So far, plenty of work has been done on melanoma, but mechanisms underlying melanoma development have not been fully elucidated. Here we identified regulator of G protein signaling 4(RGS4) as novel therapeutic target for malignant melanoma and its regulating effect on melanoma. We found that endogenous RGS4 expression was much lower in melanoma tissues and cells. In A375 cell line with low endogenous RGS4 expression, the function of RGS4 was detected by up-regulation its expression with pcDNA3...
October 3, 2017: Oncotarget
Zuwu Wei, Xiao Lin, Ming Wu, Bixing Zhao, Ruhui Lin, Da Zhang, Yun Zhang, Gang Liu, Xiaolong Liu, Jingfeng Liu
For cancer diagnosis, a paramount challenge still exists in the exploring of methods that can precisely discriminate tumor tissues from their surrounding healthy tissues with a high target-to-background signal ratio. Here, we report a NaGdF4@CaCO3-PEG core-shell nanoparticle which has the tumor acidic microenvironment enhanced imaging signals of ultrasound and magnetic resonance. Under the acidic conditions, the CaCO3 shell will gradually dissolve which then facilitate the interaction of NaGdF4 with the external aqueous environment to enhance water proton relaxation...
July 14, 2017: Scientific Reports
Simona Adesso, Tim Magnus, Salvatore Cuzzocrea, Michela Campolo, Björn Rissiek, Orlando Paciello, Giuseppina Autore, Aldo Pinto, Stefania Marzocco
Indoxyl sulfate (IS) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan which accumulates in patients with impaired renal function, such as chronic kidney disease (CKD). IS is a well-known nephrovascular toxin but little is known about its effects on central nervous system (CNS) cells. Considering the growing interest in the field of CNS comorbidities in CKD, we studied the effect of IS on CNS cells. IS (15-60 μM) treatment in C6 astrocyte cells increased reactive oxygen species release and decreased nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation, and heme oxygenase-1 (HO-1) and NAD(P)H dehydrogenase quinone 1 expression...
2017: Frontiers in Pharmacology
Zoran Culig, Martin Puhr
Interleukin (IL)-6 is a pro-inflammatory cytokine that is expressed in prostate tumors and in the stromal tumor micro-enviroment. It is known to regulate proliferation, apoptosis, angiogenesis, and differentiation. The signaling pathway of Janus kinase and signal transducer and activator of transcription (STAT)3, which is activated by IL-6, is in the focus of scientific investigations for improved treatment approaches. Different effects of IL-6 and/or STAT3 on tumor cell growth have been observed in human and murine prostate cancer (PCa) models...
February 15, 2018: Molecular and Cellular Endocrinology
Andrzej Kwolek, Krystyna Lewicka
Background. Patients undergoing rehabilitation in rehablitation wards particulary those focused on geriatry or neurology are expose to falls.It is connected with advanced age and also their illness essence.<br /> This kind of falls appears to be very important problem because some of them could lead to severe physical contusion or loss of trust in own ability and fear against the activities.<br /> The aim of this study was to analyse incidence of falls in all groups of patients rehabilited in the ward, the causes of falls and consequences of them and estabilshing the preventional rules for hemiparetic patients after stroke or operated brain's tumors...
October 30, 2002: Ortopedia, Traumatologia, Rehabilitacja
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