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https://www.readbyqxmd.com/read/29905961/treatment-planning-algorithm-for-prrt-considering-multiple-tumor-lesions-and-organs-at-risk
#1
Luis David Jiménez-Franco, Peter Kletting, Ambros J Beer, Gerhard Glatting
PURPOSE: Peptide receptor radionuclide therapy (PRRT) has shown promising results in the treatment of tumors with high expression of somatostatin receptors such as neuroendocrine tumors (NETs) and meningioma. However, PRRT potentially produces high renal and red marrow (RM) toxicity, the kidneys usually being the dose-limiting organ. Previously, it was shown that an improved therapeutic index can be achieved by choosing an optimal combination of injected activity and peptide molar amount...
June 15, 2018: Medical Physics
https://www.readbyqxmd.com/read/29877376/spectral-refractive-index-technique-for-monitoring-the-beer-mashing-process
#2
F S de Almeida, A C P Rocha, S M Lima, L H C Andrade
During beer production, the mashing process is fundamental for extraction of the main sugars from the starch. The quantification of these fermentable sugars during the process provides a measure of the alcoholic content of the final beer. Therefore, monitoring of the sugar composition during beer production is very important for obtaining a quality product. This paper demonstrates the potential of white light interferometry (WLI) for monitoring the extraction of sugars in different mashing processes, by observing the refractive index of the mixture...
June 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29871886/risk-factors-and-outcomes-of-rapid-correction-of-severe-hyponatremia
#3
Jason C George, Waleed Zafar, Ion Dan Bucaloiu, Alex R Chang
BACKGROUND AND OBJECTIVES: Rapid correction of severe hyponatremia can result in serious neurologic complications, including osmotic demyelination. Few data exist on incidence and risk factors of rapid correction or osmotic demyelination. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a retrospective cohort of 1490 patients admitted with serum sodium <120 mEq/L to seven hospitals in the Geisinger Health System from 2001 to 2017, we examined the incidence and risk factors of rapid correction and osmotic demyelination...
June 5, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29869294/pharmacist-led-medication-assessment-and-deprescribing-intervention-for-older-adults-with-cancer-and-polypharmacy-a-pilot-study
#4
Andrew Whitman, Kathlene DeGregory, Amy Morris, Supriya Mohile, Erika Ramsdale
PURPOSE: The aims of this study were to compare the application of three geriatric medication screening tools to the Beers Criteria alone for potentially inappropriate medication quantification and to determine feasibility of a pharmacist-led polypharmacy assessment in a geriatric oncology clinic. METHODS: Adult patients with cancer aged 65 and older underwent a comprehensive geriatric assessment. A polypharmacy assessment was completed by a pharmacist and included a review of all drug therapies...
June 4, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29813089/prevalence-of-helicobacter-pylori-and-its-caga-subtypes-in-gastric-cancer-and-duodenal-ulcer-at-an-austrian-tertiary-referral-center-over-25-years
#5
Yumiko Kamogawa-Schifter, Yoshio Yamaoka, Tomohisa Uchida, Andrea Beer, Barbara Tribl, Maximilian Schöniger-Hekele, Michael Trauner, Werner Dolak
BACKGROUND AND AIMS: The prevalence of Helicobacter pylori (H. pylori) tends to be lower in Western countries such as central Europe compared with Asia. The virulence of H. pylori is influenced by its subtype composition, most importantly by the presence or absence of different types of cytotoxin-associated gene A(CagA). This study aimed to assess the prevalence of H. pylori and its respective CagA phenotype in a large retrospective cohort of patients with gastric cancer or duodenal ulcer at a Western tertiary referral institution...
2018: PloS One
https://www.readbyqxmd.com/read/29671204/nafld-and-hiv-do-sex-race-and-ethnicity-explain-hiv-related-risk
#6
REVIEW
Subada Soti, Kathleen E Corey, Jordan E Lake, Kristine M Erlandson
PURPOSE OF REVIEW: Here, we review the epidemiology, diagnosis, and management of non-alcoholic fatty liver disease (NAFLD) in the general population, discuss HIV-specific differences in NAFLD pathogenesis, and summarize what is known regarding differences in NAFLD by race/ethnicity and sex. RECENT FINDINGS: The reported prevalence of NAFLD among people living with HIV varies by age, body mass index, comorbidity, and method of NAFLD diagnosis, but is generally thought to be greater among HIV-infected compared to HIV-uninfected populations...
April 18, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29608060/surface-modifier-free-organic-inorganic-hybridization-to-produce-optically-transparent-and-highly-refractive-bulk-materials-composed-of-epoxy-resins-and-zro-2-nanoparticles
#7
Kazushi Enomoto, Moriya Kikuchi, Atsushi Narumi, Seigou Kawaguchi
Surface modifier-free hybridization of ZrO2 nanoparticles (NPs) with epoxy-based polymers is demonstrated for the first time to afford highly transparent and refractive bulk materials. This is achieved by a unique and versatile hybridization via the one-pot direct phase transfer of ZrO2 NPs from water to epoxy monomers without any aggregation followed by curing with anhydride. Three types of representative epoxy monomers, bisphenol A diglycidyl ether (BADGE), 3,4-epoxycyclohexylmethyl-3',4'-epoxycyclohexane carboxylate (CEL), and 1,3,5-tris(3-(oxiran-2-yl)propyl)-1,3,5-triazinane-2,4,6-trione (TEPIC), are used to produce transparent viscous dispersions...
April 25, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29580627/alcohol-consumption-and-risk-of-coronary-artery-disease-from-the-million-veteran-program
#8
Rebecca J Song, Xuan-Mai T Nguyen, Rachel Quaden, Yuk-Lam Ho, Amy C Justice, David R Gagnon, Kelly Cho, Christopher J O'Donnell, John Concato, J Michael Gaziano, Luc Djoussé
Moderate alcohol consumption has been associated with a lower risk of coronary artery disease (CAD) in the general population but has not been well studied in US veterans. We obtained self-reported alcohol consumption from Million Veteran Program participants. Using electronic health records, CAD events were defined as 1 inpatient or 2 outpatient diagnosis codes for CAD, or 1 code for a coronary procedure. We excluded participants with prevalent CAD (n = 69,995) or incomplete alcohol information (n = 8,449)...
May 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29571478/identification-of-a-precursor-of-2-mercapto-3-methyl-1-butanol-in-beer
#9
Shigekuni Noba, Nana Yako, Hiroaki Sakai, Minoru Kobayashi, Tetsuya Watanabe
2-Mercapto-3-methyl-1-butanol (2M3MB) imparts an onion-like off-flavor to beer and is believed to result from the hot aeration of brewer's wort. However, little has been reported regarding the mechanism of formation of 2M3MB. This paper investigates the precursors of 2M3MB formed during the brewing process. Our study of a cysteine conjugate as a precursor showed its negligible contribution to the formation of 2M3MB. The 2M3MB precursor was found to be a volatile compound because 2M3MB was formed in the distillate of hop extract...
July 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29570511/whole-blood-omega-3-fatty-acid-concentrations-are-inversely-associated-with-blood-pressure-in-young-healthy-adults
#10
Mark G Filipovic, Stefanie Aeschbacher, Martin F Reiner, Simona Stivala, Sara Gobbato, Nicole Bonetti, Martin Risch, Lorenz Risch, Giovanni G Camici, Thomas F Luescher, Clemens von Schacky, David Conen, Juerg H Beer
BACKGROUND: Omega-3 fatty acids (n - 3 FA) may have blood pressure (BP)-lowering effects in untreated hypertensive and elderly patients. The effect of n - 3 FA on BP in young, healthy adults remains unknown. The Omega-3 Index reliably reflects an individuals' omega-3 status. We hypothesized that the Omega-3 Index is inversely associated with BP levels in young healthy adults. METHODS: The current study (n = 2036) is a cross-sectional study investigating the baseline characteristics of a cohort, which includes healthy adults, age 25-41 years...
March 22, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29567171/determination-of-fermentable-sugars-in-beer-wort-by-gold-nanoparticles-polydopamine-a-layer-by-layer-approach-for-localized-surface-plasmon-resonance-measurements-at-fixed-wavelength
#11
S Scarano, E Pascale, P Palladino, E Fratini, M Minunni
Polydopamine decorated in-situ with Localized Surface Plasmon Resonance (LSPR)-active gold nanoparticles (AuNPs) may extend the applicability of nanoplasmonic materials to original and innovative applications in several fields. Here we report the modification of disposable UV-Vis polystyrene cuvettes with AuNPs@PDA for refractive index LSPR-based measurements. An original layer-by-layer deposition method of PDA followed by AuNPs growth is here developed, showing linear correlation between PDA thickness and optical properties...
June 1, 2018: Talanta
https://www.readbyqxmd.com/read/29566726/increased-circulating-resistin-levels-in-early-onset-breast-cancer-patients-of-normal-body-mass-index-correlate-with-lymph-node-negative-involvement-and-longer-disease-free-survival-a-multi-center-posh-cohort-serum-proteomics-study
#12
Bashar Zeidan, Antigoni Manousopoulou, Diana J Garay-Baquero, Cory H White, Samantha E T Larkin, Kathleen N Potter, Theodoros I Roumeliotis, Evangelia K Papachristou, Ellen Copson, Ramsey I Cutress, Stephen A Beers, Diana Eccles, Paul A Townsend, Spiros D Garbis
BACKGROUND: Early-onset breast cancer (EOBC) affects about one in 300 women aged 40 years or younger and is associated with worse outcomes than later onset breast cancer. This study explored novel serum proteins as surrogate markers of prognosis in patients with EOBC. METHODS: Serum samples from EOBC patients (stages 1-3) were analysed using agnostic high-precision quantitative proteomics. Patients received anthracycline-based chemotherapy. The discovery cohort (n = 399) either had more than 5-year disease-free survival (DFS) (good outcome group, n = 203) or DFS of less than 2 years (poor outcome group, n = 196)...
March 22, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29549267/continuous-wave-highly-efficient-low-divergence-terahertz-wire-lasers
#13
Simone Biasco, Katia Garrasi, Fabrizio Castellano, Lianhe Li, Harvey E Beere, David A Ritchie, Edmund H Linfield, A Giles Davies, Miriam S Vitiello
Terahertz (THz) quantum cascade lasers (QCLs) have undergone rapid development since their demonstration, showing high power, broad-tunability, quantum-limited linewidth, and ultra-broadband gain. Typically, to address applications needs, continuous-wave (CW) operation, low-divergent beam profiles and fine spectral control of the emitted radiation, are required. This, however, is very difficult to achieve in practice. Lithographic patterning has been extensively used to this purpose (via distributed feedback (DFB), photonic crystals or microcavities), to optimize either the beam divergence or the emission frequency, or, both of them simultaneously, in third-order DFBs, via a demanding fabrication procedure that precisely constrains the mode index to 3...
March 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29506136/spatial-analysis-of-seasonal-dynamics-and-overwintering-of-drosophila-suzukii-diptera-drosophilidae-in-the-okanagan-columbia-basin-2010-2014
#14
Howard M A Thistlewood, Paramjit Gill, Elizabeth H Beers, Peter W Shearer, Doug B Walsh, Brigitte M Rozema, Susanna Acheampong, Steve Castagnoli, Wee L Yee, Peter Smytheman, Alix B Whitener
Spotted wing drosophila, Drosophila suzukii (Matsumura) (Diptera: Drosophilidae), was monitored from 2010 to 2014 in 314-828 sites located in interior fruit-growing regions of OR and WA, United States, and BC, Canada, using traps baited with apple cider vinegar or sugar-water-yeast. Seasonal population dynamics and sex ratios were summarized for berry, cherry, stone fruit, grape, non-crop host plants, non-host sites, and for conventional IPM, certified organic, backyard, and feral sites, by region and year...
April 5, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29502965/similar-superior-patient-reported-outcome-measures-for-anterior-and-posterolateral-approaches-after-total-hip-arthroplasty-postoperative-patient-reported-outcome-measure-improvement-after-3-months-in-12-774-primary-total-hip-arthroplasties-using-the-anterior
#15
Rinne M Peters, Loes W A H van Beers, Liza N van Steenbergen, Julius Wolkenfelt, Harmen B Ettema, Bas L E F Ten Have, Paul C Rijk, Martin Stevens, Sjoerd K Bulstra, Rudolf W Poolman, Wierd P Zijlstra
BACKGROUND: Patient-reported outcome measures (PROMs) are used to evaluate the outcome of total hip arthroplasty (THA). We determined the effect of surgical approach on PROMs after primary THA. METHODS: All primary THAs, with registered preoperative and 3 months postoperative PROMs were selected from the Dutch Arthroplasty Register. Based on surgical approach, 4 groups were discerned: (direct) anterior, anterolateral, direct lateral, and posterolateral approaches...
March 1, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29498476/orthostatic-hypotension-and-overall-mortality-in-1050-older-patients-of-the-outpatient-comprehensive-geriatric-assessment-unit
#16
Tamar Freud, Boris Punchik, Ella Kagan, Alex Barzak, Yan Press
AIM: Orthostatic hypotension is a common problem in individuals aged ≥65 years. Its association with mortality is not clear. The aim of the present study was to evaluate associations between orthostatic hypotension and overall mortality in a sample of individuals aged ≥65 years who were seen at the Outpatient Comprehensive Geriatric Assessment Unit, Clalit Health Services, Beer-Sheva, Israel. METHODS: Individuals who were evaluated in the Outpatient Comprehensive Geriatric Assessment Unit between January 2005 and December 2015, and who had data on orthostatic hypotension were included in the study...
March 2, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29494991/structural-and-spectrophotometric-characterization-of-2-4-dimethylamino-styryl-1-ethylquinolinium-iodide-as-a-reagent-for-sequential-injection-determination-of-tungsten
#17
Yaroslav Bazel, Martina Lešková, Michal Rečlo, Jana Šandrejová, András Simon, Maksym Fizer, Vasyl Sidey
Structure, spectrophotometric and protolytic properties of the styryl dye 2-[4-(dimethylamino)styryl]-1-ethylquinolinium iodide (R) as well as its complex with tungsten were studied. The selective protonation of dimethylamino group was confirmed by density functional theory investigation through the computation of Fukui function, NPA partial atomic charges, and NICS(0) aromaticity indexes. The TD-DFT study explains the experimental change of color by excluding the dimethylamino group from HOMO orbital upon protonation...
May 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29440620/quantification-of-hepatic-perfusion-and-hepatocyte-function-with-dynamic-gadoxetic-acid-enhanced-mri-in-patients-with-chronic-liver-disease
#18
Benjamin Leporq, Jean-Luc Daire, Catherine M Pastor, Pierre Deltenre, Christine Sempoux, Sabine Schmidt, Bernard E Van Beers
The purpose of the present study was to develop and perform initial validation of dynamic MRI enhanced with gadoxetic acid as hepatobiliary contrast agent to quantify hepatic perfusion and hepatocyte function in patients with chronic liver disease. Free-breathing, dynamic gadoxetic acid-enhanced MRI was performed at 3.0 T using a 3D time-resolved angiography sequence with stochastic trajectories during 38 min. A dual-input three-compartment model was developed to derive hepatic perfusion and hepatocyte function parameters...
April 16, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29415478/empirically-derived-dietary-patterns-in-uk-adults-are-associated-with-sociodemographic-characteristics-lifestyle-and-diet-quality
#19
Katharine Roberts, Janet Cade, Jeremy Dawson, Michelle Holdsworth
The aim of this study was to examine empirical dietary patterns in UK adults and their association with sociodemographic characteristics, lifestyle factors, self-reported nutrient intake, nutrient biomarkers, and the Nutrient-based Diet Quality Score (NDQS) using National Diet and Nutrition Survey data 2008-2012 ( n = 2083; mean age 49 years; 43.3% male). Four patterns explained 13.6% of the total variance: 'Snacks, fast food, fizzy drinks' (SFFFD), 'Fruit, vegetables, oily fish' (FVOF), 'Meat, potatoes, beer' (MPB), and 'Sugary foods, dairy' (SFD)...
February 6, 2018: Nutrients
https://www.readbyqxmd.com/read/29394184/cerebral-autoregulation-in-the-prediction-of-delayed-cerebral-ischemia-and-clinical-outcome-in-poor-grade-aneurysmal-subarachnoid-hemorrhage-patients
#20
Max Gaasch, Alois J Schiefecker, Mario Kofler, Ronny Beer, Verena Rass, Bettina Pfausler, Claudius Thomé, Erich Schmutzhard, Raimund Helbok
OBJECTIVES: Pressure reactivity index and oxygen reactivity index are used to assess cerebral autoregulation after acute brain injury. The value of autoregulation indices in the prediction of delayed cerebral ischemia and outcome in patients with subarachnoid hemorrhage is still inconclusive. In this study, we aimed to focus on the predictive value of the first 72 hours commonly referred to as "early brain injury" in comparison to the overall monitoring period. DESIGN: Retrospective observational cohort study...
May 2018: Critical Care Medicine
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