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https://www.readbyqxmd.com/read/27919698/the-use-of-partially-hydrolysed-polyvinyl-alcohol-for-the-production-of-high-drug-loaded-sustained-release-pellets-via-extrusion-spheronisation-and-coating-in-vitro-and-in-vivo-evaluation
#1
G Verstraete, W De Jaeghere, J Vercruysse, W Grymonpré, V Vanhoorne, F Stauffer, T De Beer, A Bezuijen, J P Remon, C Vervaet
Partially hydrolysed polyvinyl alcohol (PVA) was evaluated as a pelletisation aid for the production of pellets with a high acetaminophen and metformin hydrochloride concentration (>70%, w/w). Mixtures with varying drug concentration and PVA/microcrystalline cellulose (MCC) ratios were processed via extrusion-spheronisation, either after addition of PVA as a dry powder or as an aqueous solution. Finally, high drug- loaded metformin pellets were coated with a methacrylic acid copolymer (Eudragit™ NM 30D) and evaluated for their sustained release potency in vitro and in vivo...
December 2, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27861761/prediagnostic-alcohol-consumption-and-colorectal-cancer-survival-the-colon-cancer-family-registry
#2
Amanda I Phipps, Jamaica R Robinson, Peter T Campbell, Aung Ko Win, Jane C Figueiredo, Noralane M Lindor, Polly A Newcomb
BACKGROUND: Although previous studies have noted an increased risk of colorectal cancer (CRC) among moderate to heavy alcohol consumers in comparison with nondrinkers, the relation between alcohol consumption and CRC survival remains unclear. METHODS: Cases of incident invasive CRC diagnosed between 1997 and 2007 were identified via population-based cancer registries at 4 study sites in the Colon Cancer Family Registry. Study participants completed a risk-factor questionnaire on prediagnostic behaviors, including wine, beer, and liquor consumption, at the baseline...
November 8, 2016: Cancer
https://www.readbyqxmd.com/read/27842560/a-non-invasive-home-based-biomechanical-therapy-for-patients-with-spontaneous-osteonecrosis-of-the-knee
#3
Ehud Atoun, Amit Mor, Ganit Segal, Ronen Debi, Dan Grinberg, Yeshaiau Benedict, Nimrod Rozen, Yiftah Beer, Avi Elbaz
BACKGROUND: The purpose of the current study was to examine the effect of a non-invasive, home-based biomechanical treatment program for patients with spontaneous osteonecrosis of the knee (SONK). METHODS: Seventeen patients with SONK, confirmed by MRI, participated in this retrospective analysis. Patients underwent a spatiotemporal gait analysis and completed the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and the Short-Form-36 (SF-36)...
November 14, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27724954/single-source-chest-abdomen-pelvis-cancer-staging-on-a-third-generation-dual-source-ct-system-comparison-of-automated-tube-potential-selection-to-second-generation-dual-source-ct
#4
Clara Park, Tatjana Gruber-Rouh, Doris Leithner, Amelie Zierden, Mortiz H Albrecht, Julian L Wichmann, Boris Bodelle, Mohamed Elsabaie, Jan-Erik Scholtz, Moritz Kaup, Thomas J Vogl, Martin Beeres
BACKGROUND: Evaluation of latest generation automated attenuation-based tube potential selection (ATPS) impact on image quality and radiation dose in contrast-enhanced chest-abdomen-pelvis computed tomography examinations for gynaecologic cancer staging. METHODS: This IRB approved single-centre, observer-blinded retrospective study with a waiver for informed consent included a total of 100 patients with contrast-enhanced chest-abdomen-pelvis CT for gynaecologic cancer staging...
October 10, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/27695393/the-reliability-of-naturalistic-observations-of-social-physical-and-economic-environments-of-bars
#5
Christopher Morrison, Juliet P Lee, Paul J Gruenewald, Christina Mair
Drinking in bars contributes to numerous public health problems, including violence and motor vehicle crashes. In order to formulate effective preventive interventions it is essential to identify which specific features of bar environments are related to increased risks. Unobtrusive ethnographic observations are one approach that has been used to characterize these features; however no studies have assessed reliability in a representative sample of bars. We performed brief scouting assessments in all 165 bars in six purposively selected California cities, followed by unobtrusive observations from a subsequent representative sample of 97 bars which were located in low and high bar density areas of the cities...
2016: Addiction Research & Theory
https://www.readbyqxmd.com/read/27662274/alcohol-consumption-and-mortality-after-breast-cancer-diagnosis-the-health-and-functioning-in-women-study
#6
Natasha Din, Isabel Elaine Allen, William A Satariano, Joshua Demb, Dejana Braithwaite
OBJECTIVE: To determine the association of prediagnostic alcohol consumption with long-term mortality from breast cancer and other causes in a cohort of women with breast cancer. METHODS: We studied a Michigan-based cohort of 939 women aged 40-84 years, who provided complete information about the type, amount and intensity of prediagnostic alcohol consumption. Associations of alcohol consumption, based on weekly volume of alcohol consumption during the year prior to breast cancer diagnosis, with mortality were evaluated in Cox proportional hazards models, with adjustment for sociodemographic factors, body mass index, smoking, comorbidity, tumor characteristics, and treatment...
July 28, 2016: Breast Disease
https://www.readbyqxmd.com/read/27643787/timing-and-type-of-alcohol-consumption-and-the-metabolic-syndrome-elsa-brasil
#7
Bruna Angelo Vieira, Vivian Cristine Luft, Maria Inês Schmidt, Lloyd Ellwood Chambless, Dora Chor, Sandhi Maria Barreto, Bruce Bartholow Duncan
The prevalence of the metabolic syndrome is rising worldwide. Its association with alcohol intake, a major lifestyle factor, is unclear, particularly with respect to the influence of drinking with as opposed to outside of meals. We investigated the associations of different aspects of alcohol consumption with the metabolic syndrome and its components. In cross-sectional analyses of 14,375 active or retired civil servants (aged 35-74 years) participating in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), we fitted logistic regression models to investigate interactions between the quantity of alcohol, the timing of its consumption with respect to meals, and the predominant beverage type in the association of alcohol consumption with the metabolic syndrome...
2016: PloS One
https://www.readbyqxmd.com/read/27639423/body-contouring-surgery-decreases-long-term-weight-regain-following-laparoscopic-adjustable-gastric-banding-a-matched-retrospective-cohort-study
#8
Itay Wiser, Eliezer Avinoah, Oren Ziv, Adam J Parnass, Roni Averbuch Sagie, Lior Heller, Tali Friedman
BACKGROUND: Laparoscopic adjustable gastric banding (LAGB) surgery is the safest yet least effective method for massive weight loss. Thirty to 50 percent of patients undergoing LAGB will regain part of their lost weight. OBJECTIVE: To evaluate the effect of body contouring plastic surgery (BCPS) following LAGB on long-term body mass index (BMI) control. SETTING: Department of Surgery A, Soroka University Medical Center, Beer-Sheva, Israel...
September 7, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27601486/predictors-of-physical-functioning-after-total-hip-arthroplasty-a-systematic-review
#9
L D Buirs, L W A H Van Beers, V A B Scholtes, T Pastoors, S Sprague, R W Poolman
OBJECTIVE: The objective of this systematic review of the literature was to identify the predictors of functional outcome after total hip arthroplasty (THA). METHOD: A systematic literature search in Web of Science, CINAHL, EMBASE and PubMed was conducted on 23 June 2015. The articles were selected based on their quality, relevance and measurement of the predictive factor. The level of evidence of all studies was determined using the GRADE rating scheme. RESULTS: The initial search resulted in 1092 citations...
2016: BMJ Open
https://www.readbyqxmd.com/read/27524210/drug-prescribing-in-the-elderly-receiving-home-care
#10
Chien-Han Tsao, Chin-Feng Tsai, Yuan-Ti Lee, Mao-Chung Weng, Huei-Chao Lee, Ding-Bang Lin, Chun-Chieh Chen, Meng-Chih Lee, Shiuan-Chih Chen
BACKGROUND: To compare the prevalence of potentially inappropriate medications (PIMs) using the 2012 and 2003 Beers Criteria in frail older patients receiving home health care services (HHS), and to explore the correlates of PIMs based on the 2012 Beers criteria. MATERIALS AND METHODS: A total of 145 older patients (mean age, 80.9 ± 7.6 years) with Barthel scale ≤ 60 receiving regular HHS from a university hospital between January 2013 and June 2013 were retrospectively enrolled...
August 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27507463/validation-of-a-high-performance-size-exclusion-chromatography-method-to-determine-and-characterize-%C3%AE-glucans-in-beer-wort-using-a-triple-detector-array
#11
Ivan Tomasi, Ombretta Marconi, Valeria Sileoni, Giuseppe Perretti
Beer wort β-glucans are high-molecular-weight non-starch polysaccharides of that are great interest to the brewing industries. Because glucans can increase the viscosity of the solutions and form gels, hazes, and precipitates, they are often related to poor lautering performance and beer filtration problems. In this work, a simple and suitable method was developed to determine and characterize β-glucans in beer wort using size exclusion chromatography coupled with a triple-detector array, which is composed of a light scatterer, a viscometer, and a refractive-index detector...
January 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27498122/echocardiography-does-not-predict-mortality-in-hemodynamically-stable-elderly-patients-with-acute-pulmonary-embolism
#12
Eveline Hofmann, Andreas Limacher, Marie Méan, Nils Kucher, Marc Righini, Beat Frauchiger, Jürg-Hans Beer, Joseph Osterwalder, Markus Aschwanden, Christian M Matter, Martin Banyai, Michael Egloff, Olivier Hugli, Daniel Staub, Henri Bounameaux, Nicolas Rodondi, Drahomir Aujesky
BACKGROUND: The evidence on the prognostic value of transthoracic echocardiography (TTE) in elderly, hemodynamically stable patients with Pulmonary Embolism (PE) is limited. OBJECTIVES: To evaluate the prevalence of common echocardiographic signs of right ventricular (RV) dysfunction and their prognostic impact in hemodynamically stable patients aged ≥65years with acute PE in a prospective multicenter cohort. METHODS: TTE was performed by cardiologists...
September 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27441213/bvd-2-outbreak-leads-to-high-losses-in-cattle-farms-in-western-germany
#13
Jörn Gethmann, Timo Homeier, Mark Holsteg, Horst Schirrmeier, Michael Saßerath, Bernd Hoffmann, Martin Beer, Franz J Conraths
In November 2012, a dairy farmer in the district Kleve first observed a reduction in milk yield, respiratory symptoms, nasal discharge, fever, sporadic diarrhoea and sudden deaths in dairy cows and calves. In the following months, further farms were found infected with cattle showing similar clinical signs. An epidemiological investigation was carried out to identify the source of infection, the date of introduction, potential transmission pathways and to analyse the extent of the epidemic. Furthermore, laboratory analyses were conducted to characterise the causative agent...
September 2015: Heliyon
https://www.readbyqxmd.com/read/27390923/early-expressive-language-skills-predict-long-term-neurocognitive-outcomes-in-cochlear-implant-users-evidence-from-the-macarthur-bates-communicative-development-inventories
#14
Irina Castellanos, David B Pisoni, William G Kronenberger, Jessica Beer
PURPOSE: The objective of the present article was to document the extent to which early expressive language skills (measured using the MacArthur-Bates Communicative Development Inventories [CDI; Fenson et al., 2006]) predict long-term neurocognitive outcomes in a sample of early-implanted prelingually deaf cochlear implant (CI) users. METHOD: The CDI was used to index the early expressive language skills of 32 pediatric CI users after an average of 1.03 years (SD = 0...
August 1, 2016: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27322283/mitigating-beidou-satellite-induced-code-bias-taking-into-account-the-stochastic-model-of-corrections
#15
Fei Guo, Xin Li, Wanke Liu
The BeiDou satellite-induced code biases have been confirmed to be orbit type-, frequency-, and elevation-dependent. Such code-phase divergences (code bias variations) severely affect absolute precise applications which use code measurements. To reduce their adverse effects, an improved correction model is proposed in this paper. Different from the model proposed by Wanninger and Beer (2015), more datasets (a time span of almost two years) were used to produce the correction values. More importantly, the stochastic information, i...
2016: Sensors
https://www.readbyqxmd.com/read/27304318/alcohol-consumption-and-metabolic-syndrome-among-hispanics-latinos-the-hispanic-community-health-study-study-of-latinos
#16
Denise C Vidot, Mark Stoutenberg, Marc Gellman, Kristopher L Arheart, Yanping Teng, Martha L Daviglus, Hector M González, Gregory Talavera, Carmen R Isasi, Gerardo Heiss, Neil Schneiderman
BACKGROUND: The association between alcohol consumption and metabolic syndrome (MetS) among Hispanic/Latino populations has not been studied in great detail. Our study examined the relationship between alcohol consumption and MetS among U.S. Hispanics/Latinos and explored whether this relationship varied by age, body mass index, gender, and Hispanic/Latino backgrounds. METHODS: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multisite, prospective, population-based, cohort study of Hispanics/Latinos, ages 18-74 years from four U...
September 2016: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/27215965/delineating-the-antigenotoxic-and-anticytotoxic-potentials-of-4-methylimidazole-against-ethyl-methanesulfonate-toxicity-in-bone-marrow-cell-of-swiss-albino-mice
#17
M Norizadeh Tazehkand, M Topaktas, M B Yilmaz, O Hajipour, E Valipour
4-Methylimidazole (4-MEI) is mostly used in beverages and coloring food, dark beers and common brands of cola drinks, which may contain more than 100 μg of this compound per 12-ounce serving. This study was aimed to investigate the antigenotoxic and anticytotoxic effects of 4-MEI (100, 130 and 160 mg/kg) against ethyl methanesulfonate (240 mg/kg) using chromosome aberrations (CAs) and Mitotic index (MI) tests in bone marrow cells of Swiss Albino Mice at 12 h and 24 h treatment periods. So, the t-test was used for the statistical analysis...
2016: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/27178031/quantification-of-inflammatory-activity-in-patients-with-crohn-s-disease-using-diffusion-weighted-imaging-dwi-in-mr-enteroclysis-and-mr-enterography
#18
Nora Stanescu-Siegmund, Yessica Nimsch, Arthur P Wunderlich, Martin Wagner, Reinhard Meier, Markus S Juchems, Meinrad Beer, Stefan A Schmidt
BACKGROUND: Individual studies have demonstrated the potential of diffusion-weighted magnetic resonance imaging (DWI-MRI) for identifying inflamed bowel segments. However, these studies were conducted with rather small patient cohorts and in most cases by means of MR enterography only. PURPOSE: To demonstrate the feasibility of detecting inflamed bowel segments in a large collective of patients with Crohn's disease using DWI in MR enteroclysis and MR enterography and to compare the results of both techniques, also considering clinical parameters by means of the Harvey-Bradshaw Index (HBI)...
May 12, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27106572/association-of-beer-consumption-with-arsenic-concentration-in-urine-a-result-from-a-cross-sectional-study-of-the-general-japanese-population
#19
Mitsuru Mori, Tomoyo Sato, Hideki Yoshida, Yuichi Ohira, Yasushi Itou, Shouko Shimizu
OBJECTIVES: The first aim of this study was to evaluate the association between time spent living near a contaminated area and concentration of arsenic (As) compounds in the urine among study subjects. The second aim is to assess the association between consumption of various foods or beverages and As concentration in urine among them. METHODS: Urine sampling was performed on 177 persons who voluntarily participated in the survey in May 2014. The median value of the sum of inorganic As (iAs) and total As (tAs) compounds was used for us to divide into two groups, such as the high and low iAs and high and low tAs groups...
April 22, 2016: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/27069795/acute-effects-of-traditional-japanese-alcohol-beverages-on-blood-glucose-and-polysomnography-levels-in-healthy-subjects
#20
Megumi Kido, Akihiro Asakawa, Ken-Ichiro K Koyama, Toshio Takaoka, Aya Tajima, Shigeru Takaoka, Yumiko Yoshizaki, Kayu Okutsu, Kazunori T Takamine, Yoshihiro Sameshima, Akio Inui
Background. Alcohol consumption is a lifestyle factor associated with type 2 diabetes. This relationship is reportedly different depending on the type of alcohol beverage. The purpose of this study was to examine the acute effects of traditional Japanese alcohol beverages on biochemical parameters, physical and emotional state, and sleep patterns. Methods. Six healthy subjects (three men and three women; age, 28.8 ± 9.5 years; body mass index, 21.4 ± 1.6 kg/m(2)) consumed three different types of alcohol beverages (beer, shochu, and sake, each with 40 g ethanol) or mineral water with dinner on different days in the hospital...
2016: PeerJ
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