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https://www.readbyqxmd.com/read/28099527/the-association-between-osteoarthritis-and-occupational-clusters-in-the-korean-population-a-nationwide-study
#1
Hongdeok Seok, Sung Jae Choi, Jin-Ha Yoon, Gwan Gyu Song, Jong-Uk Won, Jae-Hoon Kim, Jaehoon Roh, Jae Hyun Jung
Osteoarthritis (OA) is a considerable health problem worldwide. It is known to be associated with certain occupational risk factors. We examined the prevalence rate of OA by occupational cluster. Data were collected from the Korea National Health and Nutrition Examination Surveys (2010-2013). The total number of unweighted sample size was 9,905 participants: 4,460 men and 5,445 women, and OA prevalence was 5.3% and 18.4% respectively. OA patients were defined as participants with knee/hip joint pain and radiographic change of knee/hip joint...
2017: PloS One
https://www.readbyqxmd.com/read/28098396/the-effects-of-chronic-cobalt-and-chromium-exposure-after-metal-on-metal-hip-resurfacing-an-epigenome-wide-association-pilot-study
#2
Julia Steinberg, Karan M Shah, Alison Gartland, Eleftheria Zeggini, J Mark Wilkinson
Metal-on-metal (MOM) hip resurfacing has recently been a popular prosthesis choice for the treatment of symptomatic arthritis, but results in the release of cobalt and chromium ions into the circulation that can be associated with adverse clinical effects. The mechanism underlying these effects remains unclear. While chromosomal aneuploidy and translocations are associated with this exposure, the presence of subtle structural epigenetic modifications in patients with MOM joint-replacements remains unexplored...
January 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28081584/-mini-open-approach-shows-good-results-in-treatment-of-femoroacetabular-impingement
#3
Stephanie Maria Kirschbaum, Frank Sitterlee, Carsten Perka, Michael Müller
Background Femoroacetabular impingement (FAI) describes a painful, abnormal (bony) contact between the femoral neck and acetabulum, which, if left untreated, contributes to early osteoarthritis (OA) of the hip. Despite its flat learning curve and long operation times, hip arthroscopy has been used increasingly often in recent years in the surgery of femoroacetabular impingement. The mini-open technique (MOT) offers a possible alternative that addresses the abnormal morphological prominence and allows minimally invasive clearance of hip motion...
January 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28068972/an-underlying-diagnosis-of-osteonecrosis-of-bone-is-associated-with-worse-outcomes-than-osteoarthritis-after-total-hip-arthroplasty
#4
Jasvinder A Singh, Jason Chen, Maria C S Inacio, Robert S Namba, Elizabeth W Paxton
BACKGROUND: Well-designed studies of complications and readmission rates in patients undergoing total hip arthroplasty (THA) with osteonecrosis are lacking. Our objective was to examine if a diagnosis of osteonecrosis was associated with complications, mortality and readmission rates after THA. METHODS: We analyzed prospectively collected data from an integrated healthcare system's Total Joint Replacement Registry of adults with osteonecrosis vs. osteoarthritis (OA) undergoing unilateral primary THA during 2001-2012, in an observational cohort study...
January 9, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28068837/immediate-effects-of-acupuncture-treatment-on-intra-and-inter-limb-contributions-to-body-support-during-gait-in-patients-with-bilateral-medial-knee-osteoarthritis
#5
Yen-Hung Liu, I-Pin Wei, Ting-Ming Wang, Tung-Wu Lu, Jaung-Geng Lin
Knee osteoarthritis (OA) often leads to altered balance control, joint motion and loading patterns during gait. Acupuncture has been proven to be effective in pain relief but its effects on inter-joint load-sharing for body balance have not been reported. The current study bridged the gap by quantifying the immediate effects of acupuncture on the inter-joint and inter-limb load-sharing in patients with knee OA during level walking in terms of the total support moment (Ms) and the contribution of individual joints to the total support moment...
January 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28066746/arthroscopic-treatment-of-femoroacetabular-impingement-in-patients-older-than-60-years
#6
Rodrigo Mardones, Alessio Giai Via, Alvaro Rivera, Alexander Tomic, Marcelo Somarriva, Mauricio Wainer, Daniel Camacho
BACKGROUND: The indications of hip arthroscopy increased over the past decade. Although mostly recommended for treatment of femoroacetabular impingement (FAI) in young patients, well-selected older patients (> 60 years old) may benefit from this surgery. However, the role of hip arthroscopy for the management of older patients is controversial. The aim of the study is to evaluate the clinical outcomes of a series of patients aged 60 years and older who underwent hip arthroscopy for FAI at mid-term follow-up...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28066741/cell-therapy-for-cartilage-defects-of-the-hip
#7
Rodrigo Mardones, Alessio Giai Via, Claudio Jofré, José Minguell, Claudio Rodriguez, Alexander Tomic, Matias Salineros
BACKGROUND: Chondral injuries are commonly related to poor clinical outcome, but recent data showed some improvements in function and pain after hip arthroscopy. Cell-based therapies represent an appealing alternative strategy for cartilage regeneration, and interesting results have been recently reported after intra-articular injections of mesenchymal stem cells (MSCs). The results of hip arthroscopy for femoroacetabular impingement (FAI) and intra-articular injections of autologous expanded bone marrow - MSCs (BM-MSCs) are reported in this retrospective study...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28063649/biologic-drugs-as-analgesics-for-the-management-of-osteoarthritis
#8
REVIEW
Theodoros Dimitroulas, Tosin Lambe, Rainer Klocke, George D Kitas, Rui V Duarte
BACKGROUND: Biologic drugs are novel therapeutic agents with demonstrated effectiveness in the management of a variety of chronic inflammatory disorders. Unmet needs in the treatment of chronic pain have led physicians to utilize a similar approach to patients suffering from conditions not characterized by systemic inflammation such as osteoarthritis (OA). The aim of this review is to discuss the current knowledge on the use of commonly used biologic agents [i.e., anti-tumor necrosis factor alpha (anti-TNF alpha) and anti-nerve growth factor (anti-NGF)] for the management of OA...
December 5, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28057012/clinical-results-of-arthroscopic-surgery-in-patients-over-50%C3%A2-years-of-age-what-viability-does-it-have-as-a-joint-preservative-surgery
#9
Mitsutoshi Moriya, Kensuke Fukushima, Katsufumi Uchiyama, Naonobu Takahira, Takeaki Yamamoto, Yojiro Minegishi, Masashi Takaso
BACKGROUND: To identify whether hip arthroscopy is a suitable option for treating hip pain in elderly patients and investigate the clinical outcomes of hip arthroscopic surgery for labrum tear and/or osteoarthritis in patients over 50 years of age. METHODS: Between August 2009 and May 2014, a series of 23 patients (6 men and 17 women) with a mean age of 59 years underwent arthroscopy. We retrospectively examined the clinical records, radiographs, and outcome questionnaires from all patients...
January 6, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28043937/efficacy-and-safety-of-duloxetine-in-chinese-patients-with-chronic-pain-due-to-osteoarthritis-a-randomized-double-blind-placebo-controlled-study
#10
Guochun Wang, LiQi Bi, Xiangpei Li, Zhijun Li, Dongbao Zhao, Jinwei Chen, Dongyi He, Chia-Ning Wang, Héctor Dueñas, Vladimir Skljarevski, Li Yue
OBJECTIVE: We assessed the efficacy and safety of duloxetine (60 mg, once daily), compared with placebo, during a 13-week treatment period in Chinese patients with chronic pain due to osteoarthritis (OA). DESIGN: Patients were at least 40 years old (male or female) who met American College of Rheumatology clinical and radiographic criteria for the diagnosis of OA of the knee or hip. The primary efficacy measure in this phase 3, randomized, double-blind, placebo-controlled clinical trial was assessment of pain severity by the Brief Pain Inventory (BPI) 24-hour Average Pain rating...
December 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28041611/the-mechanics-of-focal-chondral-defects-in-the-hip
#11
Brenden J Klennert, Benjamin J Ellis, Travis G Maak, Ashley L Kapron, Jeffrey A Weiss
There is a mean incidence of osteoarthritis (OA) of the hip in 8% of the overall population. In the presence of focal chondral defects, defined as localized damage to the articular cartilage, there is an increased risk of symptomatic progression toward OA. This relationship between chondral defects and subsequent development of OA has led to substantial efforts to develop effective procedures for surgical cartilage repair. This study examined the effects of chondral defects and labral delamination on cartilage mechanics in the dysplastic hip during the gait cycle using subject-specific finite element analysis...
November 29, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28034979/efficacy-and-safety-of-tanezumab-on-osteoarthritis-knee-and-hip-pains-a-meta-analysis-of-randomized-controlled-trials
#12
Junyuan Chen, Jieruo Li, Ruobin Li, Huajun Wang, Jie Yang, Jichun Xu, Zhengang Zha
OBJECTIVES:  To evaluate the efficacy and safety of tanezumab for management of osteoarthritis (OA) knee and hip pain. METHODS:  Articles about management of OA knee and hip pains by tanezumab were systematically searched in PubMed, EBSCO, EMBASE, ScienceDirect, Web of Science, OVID, and Cochrane Library from the available date of inception until January 2016. Randomized controlled trials (RCTs) comparing the efficacy and safety of tanezumab with placebo/active comparator for management of OA knee and hip pains were included, and those with confounding conditions were excluded...
December 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28032035/seasonal-variation-in-adult-hip-disease-secondary-to-osteoarthritis-and-developmental-dysplasia-of-the-hip
#13
Tatsuya Sueyoshi, Merrill A Ritter, Kenneth E Davis, Randall T Loder
AIM: To determine if there was a seasonal variation in adults undergoing total hip arthroplasty for end stage hip disease due to osteoarthritis (OA) or sequelae of developmental dysplasia of the hip (DDH). METHODS: The total hip registry from the author's institution for the years 1969 to 2013 was reviewed. The month of birth, age, gender, and ethnicity was recorded. Differences between number of births observed and expected in the winter months (October through February) and non-winter mo (March through September) were analyzed with the χ(2) test...
December 18, 2016: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28028161/cartilage-biomarkers-in-the-osteoarthropathy-of-alkaptonuria-reveal-low-turnover-and-accelerated-ageing
#14
Adam M Taylor, Ming-Feng Hsueh, Lakshminarayan R Ranganath, James A Gallagher, Jane P Dillon, Janet L Huebner, Jon B Catterall, Virginia B Kraus
OBJECTIVE: Alkaptonuria (AKU) is a rare autosomal recessive disease resulting from a single enzyme deficiency in tyrosine metabolism. As a result, homogentisic acid cannot be metabolized, causing systemic increases. Over time, homogentisic acid polymerizes and deposits in collagenous tissues, leading to ochronosis. Typically, this occurs in joint cartilages, leading to an early onset, rapidly progressing osteoarthropathy. The aim of this study was to examine tissue turnover in cartilage affected by ochronosis and its role in disease initiation and progression...
January 2017: Rheumatology
https://www.readbyqxmd.com/read/28028160/predictive-value-of-mri-features-for-development-of-radiographic-osteoarthritis-in-a-cohort-of-participants-with-pre-radiographic-knee-osteoarthritis-the-check-study
#15
Kim van Oudenaarde, Björn Jobke, Ans C M Oostveen, Annekarien C A Marijnissen, Ron Wolterbeek, Janet Wesseling, Sita M A Bierma-Zeinstra, Hans L Bloem, Monique Reijnierse, Margreet Kloppenburg
OBJECTIVE: To determine whether MRI features are associated with development of radiographic knee OA and can be used as a predictive tool in early knee OA. METHODS: In 148 participants of the Cohort Hip and Cohort Knee study (mean age 56 years, 78% women), with a Kellgren Lawrence (KL) score ⩽1, we obtained semi-quantitatively scored knee MRI scans and radiographs at baseline. After 5 years, we determined the development of radiographic knee OA (KL ⩾2). We calculated odds ratios (ORs), with 95% CIs adjusted for age, sex and BMI, to identify MRI features associated with OA development...
January 2017: Rheumatology
https://www.readbyqxmd.com/read/28009135/diagnostics-of-femoral-head-status-in-humans-using-laser-spectroscopy-in-vitro-studies
#16
Huiying Lin, Wansha Li, Hao Zhang, Peng Chen, Delong Chen, Wei He, Sune Svanberg, Katarina Svanberg
Osteonecrosis of the femoral head (ONFH), a recalcitrant and disabling disease, is caused by inadequate or fully disrupted blood supply to the affected segment of the subchondral bone. Theoretically, there will develop gas-filled pores during the bone decay process due to lacking blood supply. Unfortunately, the relationship between the gas-filled pores and ONFH is still unclear. Here, we have introduced diode laser absorption spectroscopy to detect oxygen and water vapor signals in the femoral heads from hip replacement in 19 patients...
December 23, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27999816/evidence-for-altered-canonical-wnt-signaling-in-the-trabecular-bone-of-elderly-postmenopausal-women-with-fragility-femoral-fracture
#17
Simona Bolamperti, Isabella Villa, Alice Spinello, Greta Manfredini, Emanuela Mrak, Umberto Mezzadri, Marco Ometti, Gianfranco Fraschini, Francesca Guidobono, Alessandro Rubinacci
Wnt signaling, a major regulator of bone formation and homeostasis, might be involved in the bone loss of osteoporotic patients and the consequent impaired response to fracture. Therefore we analyzed Wnt-related, osteogenic, and adipogenic genes in bone tissue of elderly postmenopausal women undergoing hip replacement for either femoral fracture or osteoarthritis. Bone specimens derived from the intertrochanteric region of the femurs of 25 women with fracture (F) and 29 with osteoarthritis without fracture (OA) were analyzed...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27996342/sick-leave-in-sweden-before-and-after-total-joint-replacement-in-hip-and-knee-osteoarthritis-patients
#18
Kjerstin Stigmar, Leif E Dahlberg, Caddie Zhou, Helena Jacobson Lidgren, Ingemar F Petersson, Martin Englund
Background and purpose - Little is know about patterns of sick leave in connection with total hip and knee joint replacement (THR and TKR) in patients with osteoarthritis (OA). Patients and methods - Using registers from southern Sweden, we identified hip and knee OA patients aged 40-59 years who had a THR or TKR in the period 2004-2012. Patients who died or started on disability pension were excluded. We included 1,307 patients with THR (46% women) and 996 patients with TKR (56% women). For the period 1 year before until 2 years after the surgery, we linked individual-level data on sick leave from the Swedish Social Insurance Agency...
December 20, 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27992684/hip-shape-as-a-predictor-of-osteoarthritis-progression-in-a-prospective-population-cohort
#19
Harbeer G Ahedi, Richard M Aspden, Leigh C Blizzard, Fiona R Saunders, Flavia M Cicuttini, Dawn A Aitken, Graeme Jones, Jennifer S Gregory
OBJECTIVE: Hip morphology plays a significant role in the incidence and progression of hip osteoarthritis (OA). We hypothesized that hip shape would also associate with other key factors and tested this in a longitudinal community-based cohort combining radiographic, MRI, DXA, and clinical data. METHODS: Baseline dual-energy X-ray absorptiometry (DXA) images of the left hip of 831 subjects from the Tasmanian Older Adult Cohort (TASOAC) were analyzed using an 85-point statistical shape model...
December 19, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27980494/in-vivo-osteoinduction-evaluating-2-beta-coxatene-as-an-immunoinductive-compound-and-novel-ingredient-for-joint-support
#20
Katherine Spinks, James J Scaffidi
CONTEXT: Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss of articular cartilage. Many treatments lack the ability to stimulate the growth of native cartilage tissue while they simultaneously increase joint comfort. For the past few decades, dietary supplements have been investigated for the ability to both address joint inflammation and stimulate cartilage tissue. OBJECTIVES: The present study intended to examine the supplement's in vivo osteoinductive capabilities and clinical efficacy for overall joint health...
October 2016: Integrative Medicine
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