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https://www.readbyqxmd.com/read/28937277/injectable-viscoelastic-supplements-a-review-for-radiologists
#1
Dermot J Bowden, Caoimhe A Byrne, Abdullah Alkhayat, Stephen J Eustace, Eoin C Kavanagh
OBJECTIVE: Hyaluronic acid (HA) is increasingly used by musculoskeletal radiologists in the treatment of osteoarthritis (OA). Although the evidence base for its efficacy is controversial, it remains in common use. With initial evidence suggesting its efficacy in the knee, it is now offered for treating OA of the hip, ankle, and elsewhere. CONCLUSION: HA is available in a wide variety of preparations, which may vary in concentration and chemical composition. Clinicians offering intraarticular HA injection should be familiar with the common preparations available and the principal differences between them, its mechanism of action, and the profile of adverse effects associated with its use...
October 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28934396/evaluation-of-shared-genetic-aetiology-between-osteoarthritis-and-bone-mineral-density-identifies-smad3-as-a-novel-osteoarthritis-risk-locus
#2
Sophie Hackinger, Katerina Trajanoska, Unnur Styrkarsdottir, Eleni Zengini, Julia Steinberg, Graham R S Ritchie, Konstantinos Hatzikotoulas, Arthur Gilly, Evangelos Evangelou, John P Kemp, David Evans, Thorvaldur Ingvarsson, Helgi Jonsson, Unnur Thorsteinsdottir, Kari Stefansson, Andrew W McCaskie, Roger A Brooks, Jeremy M Wilkinson, Fernando Rivadeneira, Eleftheria Zeggini
Osteoarthritis (OA) is a common complex disease with high public health burden and no curative therapy. High bone mineral density (BMD) is associated with an increased risk of developing OA, suggesting a shared underlying biology. Here, we performed the first systematic overlap analysis of OA and BMD on a genome wide scale. We used summary statistics from the GEFOS consortium for lumbar spine (n = 31,800) and femoral neck (n = 32,961) BMD, and from the arcOGEN consortium for three OA phenotypes (hip, ncases=3,498; knee, ncases=3,266; hip and/or knee, ncases=7,410; ncontrols=11,009)...
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28927561/interobserver-and-intraobserver-reliability-of-three-dimensional-preoperative-planning-software-in-total-hip-arthroplasty
#3
Yasushi Wako, Junichi Nakamura, Michiaki Miura, Yuya Kawarai, Masahiko Sugano, Kento Nawata
BACKGROUND: The purpose of this study is to clarify interobserver and intraobserver reliabilities of the three-dimensional (3D) templating of total hip arthroplasty (THA). METHODS: We selected preoperative computed tomography from 60 hips in 46 patients (14 men and 32 women) who underwent primary THA. To evaluate interobserver and intraobserver reliability, 6 orthopedic surgeons performed 3D templating twice over a 4-week interval. We investigated intraclass correlation coefficients (ICCs) and percent agreement of component size and alignment, comparing morphological differences in the hip...
September 1, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28927387/development-of-the-treatment-beliefs-in-knee-and-hip-osteoarthritis-toa-questionnaire
#4
Ellen M H Selten, Johanna E Vriezekolk, Henk J Schers, Marc W Nijhof, Willemijn H van der Laan, Roelien G van der Meulen-Dilling, Rinie Geenen, Cornelia H M van den Ende
BACKGROUND: Use of conservative treatment modalities in osteoarthritis (OA) is suboptimal, which appears to be partly due to patients' beliefs about treatments. The aim of this study was to develop a research instrument assessing patients' beliefs about various treatment modalities of hip and knee OA: the 'Treatment beliefs in OA (TOA) questionnaire'. METHODS: The item pool that was retrieved from interviews with patients and healthcare providers comprised beliefs regarding five treatment modalities: physical activity, pain medication, physiotherapy, injections and arthroplasty...
September 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28926466/barriers-impeding-the-use-of-non-pharmacological-non-surgical-care-in-hip-and-knee-osteoarthritis-the-views-of-general-practitioners-physical-therapists-and-medical-specialists
#5
Ellen M H Selten, Johanna E Vriezekolk, Marc W Nijhof, Henk J Schers, Roelien G van der Meulen-Dilling, Willemijn H van der Laan, Rinie Geenen, Cornelia H M van den Ende
BACKGROUND: Non-pharmacological, non-surgical treatment modalities are underused in the management of knee and hip osteoarthritis (OA). One possible explanation for this could be healthcare providers' opinions about these treatment modalities. The objective of this qualitative study was to identify healthcare providers' views on non-pharmacological, non-surgical care for OA. METHODS: Semi-structured in-depth interviews with 24 healthcare providers (rheumatologists, orthopedic surgeons, physical therapists and general practitioners) were held...
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28918594/the-association-of-knee-structural-pathology-with-pain-at-the-knee-is-modified-by-pain-at-other-sites-in-those-with-knee-osteoarthritis
#6
Feng Pan, Jing Tian, Dawn Aitken, Flavia Cicuttini, Tania Winzenberg, Graeme Jones
The objective of this study was to investigate the associations of knee structural abnormalities with different patterns of pain. A total of 891 participants (average age 63 years; range 50 to 80 years) participated in this study. Presence of pain at the neck, back, hands, shoulders, hips, knees, and feet was assessed by questionnaire. Participants were categorized as having no pain at any site (no pain), pain only at the knee (KP), pain at other sites but not the knee (OP), and pain at the knee and other sites (KOP)...
September 16, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28906050/labral-calcification-in-end-stage-osteoarthritis-of-the-hip-correlates-with-pain-and-clinical-function
#7
Jan Hubert, Thelonius Hawellek, Martin Moe, Sandra Hischke, Matthias Krause, Tim Rolvien, Tobias Schmidt, Wolfgang Rüther, Andreas Niemeier
The acetabular labrum of the hip (ALH) is recognized as a clinically important structure, but knowledge about the pathophysiology of this fibrocartilage is scarce. In this prospective study we determined the prevalence of ALH calcification in patients with end-stage osteoarthritis (OA) and analyzed the relationship of cartilage calcification (CC) with hip pain and clinical function. Cohort of 80 patients (70.2±7.6years) with primary OA scheduled for total hip replacement. Harris Hip Score (HHS) was recorded preoperatively...
September 14, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28899433/wearable-sensors-to-predict-improvement-following-an-exercise-intervention-in-patients-with-knee-osteoarthritis
#8
Dylan Kobsar, Sean T Osis, Jeffrey E Boyd, Blayne A Hettinga, Reed Ferber
BACKGROUND: Muscle strengthening exercises consistently demonstrate improvements in the pain and function of adults with knee osteoarthritis, but individual response rates can vary greatly. Identifying individuals who are more likely to respond is important in developing more efficient rehabilitation programs for knee osteoarthritis. Therefore, the purpose of this study was to determine if pre-intervention multi-sensor accelerometer data (e.g., back, thigh, shank, foot accelerometers) and patient reported outcome measures (e...
September 12, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28893757/effectiveness-and-cost-effectiveness-of-duloxetine-added-to-usual-care-for-patients-with-chronic-pain-due-to-hip-or-knee-osteoarthritis-protocol-of-a-pragmatic-open-label-cluster-randomised-trial-the-duo-trial
#9
Jacoline J van den Driest, Dieuwke Schiphof, Pim A J Luijsterburg, Aafke R Koffeman, Marc A Koopmanschap, Patrick J E Bindels, Sita M A Bierma-Zeinstra
INTRODUCTION: Osteoarthritis (OA) is a highly prevalent painful condition of the musculoskeletal system. The effectiveness of current analgesic options has proven to be limited and improved analgesic treatment is needed. Several randomised placebo-controlled trials have now demonstrated the efficacy of duloxetine, an antidepressant with a centrally acting effect, in the treatment of OA pain. The aim of the current study is to investigate if duloxetine is effective and cost-effective as a third-choice analgesic added to usual care for treating chronic pain compared with usual care alone in general practice...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28893678/hip-inflammation-mri-scoring-system-himriss-to-predict-response-to-hyaluronic-acid-injection-in-hip-osteoarthritis
#10
Nicolas Deseyne, Thierry Conrozier, Henri Lellouche, Bernard Maillet, Ulrich Weber, Jacob L Jaremko, Joel Paschke, Jonathan Epstein, Walter P Maksymowych, Damien Loeuille
OBJECTIVE: To assess predictors of response, according to hip MRI inflammatory scoring system (HIMRISS), in a sample of patients with hip osteoarthritis (OA) treated by hyaluronic acid (HA) injection. METHOD: 60 patients with hip OA were included. Clinical outcomes were assessed at baseline and three months after HA injection by WOMAC. On hip MRI performed before HA injection, bone marrow lesion (BML) and synovitis were assessed by HIMRISS by four readers. The inter-reader reliability of HIMRISS was for HIMRISS total, acetabular BML, femoral BML and synovitis-effusion respectively 0...
September 8, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28893229/neuroimmune-expression-in-hip-osteoarthritis-a-systematic-review
#11
Manuel Ribeiro da Silva, Daniela Linhares, Daniel Marques Vasconcelos, Cecilia Juliana Alves, Nuno Neves, Gilberto Costa, Meriem Lamghari
BACKGROUND: Neuroimmune axis is central in the physiopathology of hip osteoarthritis (OA), but its specific pathways are still unclear. This systematic review aims to assess the nervous and immune system profile of patients with hip osteoarthritis (OA) when compared to healthy controls. METHODS: A systematic review followed PRISMA guidelines was conducted. A two-step selection process was completed, and from 609 references 17 were included. The inclusion criteria were: original articles on adult patients with hip OA, with assessment of neuroimmune expression...
September 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28889010/pain-in-osteoarthritis-implications-for-optimal-management
#12
Anne-Priscille Trouvin, Serge Perrot
Pain is an ubiquitous symptom in osteoarticular diseases, occurring much more commonly than stiffness or disability. OA of the knee, hand, or hip affects around 20% of adults in various populations and is dramatically increasing in many countries, mostly related to age and obesity, leading to an increased number of people having OA pain, and creating a huge burden related to disability and health care costs. OA-related pain, has been classically considered to be a nociceptive pain condition. Clinicians have considered pain to be an alarm signal, correlated to the intensity of joint degradation...
September 6, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28880733/healthcare-resource-utilization-and-costs-by-age-and-joint-location-among-osteoarthritis-patients-in-a-privately-insured-population
#13
Susanne X Wang, Arijit X Ganguli, Amit Bodhani, Jeroen K Medema, William M Reichmann, Dendy Macaulay
AIMS: To compare healthcare resource utilization and costs between patients aged 18 to 64 years with osteoarthritis (OA) and matched controls without OA in a privately insured population. METHODS: Patients with OA were selected from de-identified U.S.-based employer claims (Q1:1999-Q3:2011). The index date was defined as the first OA diagnosis indicated by ICD-9-CM codes. One year before and after the index date were defined as the baseline and study periods, respectively...
September 7, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28875826/current-treatment-options-for-osteoarthritis
#14
Sevdalina Lambova, Walter Hermann, Ulf Müller-Ladner
BACKGROUND: Osteoarthritis (ОА) is the most common joint disease and a leading cause for impaired function and disability with significant treatment costs and socio-economic burden. Despite recent achievements in the knowledge on disease pathogenesis, the treatment is still a challenge and contrary to inflammatory joint diseases, no disease-modifying drugs are currently available for OA. OBJECTIVE: Different response in different localizations of the disease further complicates the therapeutic choice...
August 29, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28869185/gait-variability-and-motor-control-in-patients-with-knee-osteoarthritis-as-measured-by-the-uncontrolled-manifold-technique
#15
Gwenllian Fflur Tawy, Philip Rowe, Leela Biant
Knee osteoarthritis (OA) causes pain, reduced muscular strength and stiffness of the affected joint. In response, the motor control mechanism is altered, potentially compromising stability during acts of daily living. Reduced walking stability can be quantified in terms of gait variability. This study therefore aimed to identify and quantify the effects of knee arthritis on gait variability. Fifty adults (25 males/25 females) with end-stage OA of the knee sufficiently symptomatic to require joint replacement, walked on a self-paced treadmill for 2min...
August 18, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28854938/the-assessment-of-femoral-shaft-morphology-in-the-sagittal-plane-in-chinese-patients-with-osteoarthritis-a-radiographic-analysis
#16
Zhengyuan Bao, Liang Qiao, Jianghui Qin, Jiacheng Xu, Sheng Zhou, Dongyang Chen, Dongquan Shi, Jin Dai, Yao Yao, Qing Jiang, Zhihong Xu
BACKGROUND: The purpose of this study was to analyze femoral shaft sagittal parameters in Chinese osteoarthritis (OA) patients undergoing total knee arthroplasty (TKA) and identify whether the parameters in the coronal plane could be predictors of those in the sagittal plane. METHODS: Standard long-standing anteroposterior and femoral lateral radiographs of 50 lower limbs in 50 Chinese OA patients were included. Sagittal femoral bowing angle (sFBA), angle between femoral distal anterior cortex axis and sagittal mechanical axis (DACSMA), angle between femoral distal anterior cortex axis and sagittal distal anatomic axis (DACSDAA), and angle between femoral sagittal mechanical axis and sagittal distal anatomic axis (SMADAA) were measured...
August 30, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28836259/cartilage-matrix-remodelling-differs-by-disease-state-and-joint-type
#17
M-F Hsueh, V B Kraus, P Önnerfjord
Dramatic alterations in mechanical properties have been documented for osteoarthritic (OA) cartilage. However, the matrix composition underlying these changes has not been mapped and their aetiology is not entirely understood. We hypothesised that an understanding of the cartilage matrix heterogeneity could provide insights into the origin of these OA-related alterations. We generated serial transverse cryo sections for 7 different cartilage conditions: 2 joint sites (knee and hip), 2 disease states (healthy and OA) and 3 tissue depths (superficial, middle and deep)...
August 24, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28831651/treatment-of-stable-slipped-capital-femoral-epiphysis-systematic-review-and-exploratory-patient-level-analysis
#18
H Naseem, S Chatterji, K Tsang, M Hakimi, A Chytas, S Alshryda
BACKGROUND: Several aspects of slipped capital femoral epiphysis (SCFE) treatment remain controversial. Loder's work has been instrumental in changing our understanding and approach to the management of the condition when he introduced the concept of "slip instability" and showed that avascular necrosis (AVN) developed in 47% of unstable slips but none of the stable slips. As the two types of SCFE behave differently in terms of presentation, progress and complications, we approached them as two different conditions to highlight these differences...
August 22, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28830491/a-randomized-double-blind-placebo-controlled-trial-to-investigate-the-effectiveness-and-safety-of-a-novel-green-lipped-mussel-extract-biolex%C3%A2-for-managing-pain-in-moderate-to-severe-osteoarthritis-of-the-hip-and-knee
#19
RANDOMIZED CONTROLLED TRIAL
Simon Stebbings, Andrew Gray, Anthony G Schneiders, Andrew Sansom
BACKGROUND: Extracts from perna canaliculus, the Green Lipped Mussel (GLM) are widely used as a complimentary therapy by patients with osteoarthritis (OA). The current study investigated the potential of a novel GLM formulation as a treatment for OA. A randomized double-blind placebo-controlled trial was undertaken to assess potential impacts on pain and quality of life following 12 weeks of treatment. METHODS: Eighty patients with moderate to severe OA of the hip or knee were randomized to receive either 600 mg of BioLex®-GLM daily or placebo for 12 weeks...
August 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28827734/integrative-epigenomics-transcriptomics-and-proteomics-of-patient-chondrocytes-reveal-genes-and-pathways-involved-in-osteoarthritis
#20
Julia Steinberg, Graham R S Ritchie, Theodoros I Roumeliotis, Raveen L Jayasuriya, Matthew J Clark, Roger A Brooks, Abbie L A Binch, Karan M Shah, Rachael Coyle, Mercedes Pardo, Christine L Le Maitre, Yolande F M Ramos, Rob G H H Nelissen, Ingrid Meulenbelt, Andrew W McCaskie, Jyoti S Choudhary, J Mark Wilkinson, Eleftheria Zeggini
Osteoarthritis (OA) is a common disease characterized by cartilage degeneration and joint remodeling. The underlying molecular changes underpinning disease progression are incompletely understood. We investigated genes and pathways that mark OA progression in isolated primary chondrocytes taken from paired intact versus degraded articular cartilage samples across 38 patients undergoing joint replacement surgery (discovery cohort: 12 knee OA, replication cohorts: 17 knee OA, 9 hip OA patients). We combined genome-wide DNA methylation, RNA sequencing, and quantitative proteomics data...
August 21, 2017: Scientific Reports
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