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https://www.readbyqxmd.com/read/28215059/motives-for-physical-exercise-participation-as-a-basis-for-the-development-of-patient-oriented-exercise-interventions-in-osteoarthritis-a-cross-sectional-study
#1
Inga Krauss, Uwe Katzmarek, Monika A Rieger, Gorden Sudeck
BACKGROUND: Physical exercises are effective in the treatment of osteoarthritis (OA). There is consensus that exercise interventions should take into account the patient's preferences and needs in order to improve compliance to exercise regimes. One important personal factor is the patient's motivation for physical exercise. Health improvement is a relevant motive for exercise participation. Accordingly, exercise interventions primarily focus on health related needs such as strengthening and pain reduction...
February 17, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28202082/bone-morphogenetic-proteins-and-myostatin-pathways-key-mediator-of-human-sarcopenia
#2
Manuel Scimeca, Eleonora Piccirilli, Francesca Mastrangeli, Cecilia Rao, Maurizio Feola, Augusto Orlandi, Elena Gasbarra, Elena Bonanno, Umberto Tarantino
BACKGROUND: Sarcopenia, osteoporosis and osteoarthritis are the most frequent musculoskeletal disorders affecting older people. The main aim of this study was to test the hypothesis that the balance between BMPs and myostatin pathways regulates the age-related muscle degeneration in OP and OA patients. To this end, we investigated the relationship among the expression of BMP-2/4-7, myostatin and phosphorylated Smads1-5-8 and the muscle quality, evaluated in term of fibers atrophy and satellite cells activity...
February 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28194709/high-survivorship-and-little-osteoarthritis-at-10-year-followup-in-scfe-patients-treated-with-a-modified-dunn-procedure
#3
Kai Ziebarth, Milan Milosevic, Till D Lerch, Simon D Steppacher, Theddy Slongo, Klaus A Siebenrock
BACKGROUND: The modified Dunn procedure has the potential to restore the anatomy in hips with slipped capital femoral epiphyses (SCFE) while protecting the blood supply to the femoral head and minimizing secondary impingement deformities. However, there is controversy about the risks associated with the procedure and mid- to long-term data on clinical outcomes, reoperations, and complications are sparse. QUESTIONS/PURPOSES: Among patients treated with a modified Dunn procedure for SCFE, we report on (1) hip pain and function as measured by the Merle d'Aubigné and Postel score, Drehmann sign, anterior impingement test, limp, and ROM; (2) the cumulative survivorship at minimum 10-year followup with endpoints of osteoarthritis (OA) progression (at least one Tönnis grade), subsequent THA, or a Merle d'Aubigné and Postel score < 15; (3) radiographic anatomy of the proximal femur measured by slip angle, α angle, Klein line, and sphericity index; and (4) the risk of subsequent surgery and complications...
February 13, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28185391/severe-cartilage-degeneration-in-patients-with-developmental-dysplasia-of-the-hip
#4
Wei-Jia Feng, Hui Wang, Chao Shen, Jun-Feng Zhu, Xiao-Dong Chen
Developmental dysplasia of the hip (DDH) is a developmental disorder that has long-term chronic pain and limited hip joint mobility as major pathological characteristics. This study aims to access the association between the development of DDH and cartilage metabolic disorders. Cartilage tissue samples were acquired from patients with DDH, osteoarthritis (OA) and femoral neck fracture. The proteoglycan level was evaluated by safranin O-fast green, toluidine blue and hematoxylin-eosin (HE) staining. The levels of collagen-II (Col-II), collagen-X (Col-X) and metal matrix proteinase-13 (MMP-13) were evaluated by immunohistochemistry (IHC) and Western blotting analysis...
February 10, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28185060/simultaneous-bilateral-total-hip-arthroplasties-in-nonagenarians
#5
REVIEW
F R Power, D T Cawley, P D Curtin
Total hip arthroplasty (THA) is an effective and durable treatment option for hip osteoarthritis (OA). As life expectancy continues to increase, so too will the demand for joint arthroplasty in the 10th decade of life, frequently in cases involving osteoarthritis of both hips. Simultaneous bilateral total hip arthroplasty (SBTHA) is a valuable therapeutic option in appropriately selected patients with bilateral degenerative hip disease, although its use in the very elderly is poorly reported on in the literature...
February 9, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28178164/blood-mean-platelet-volume-and-platelet-lymphocyte-ratio-as-new-predictors-of-hip-osteoarthritis-severity
#6
Özlem Taşoğlu, Ali Şahin, Gülşah Karataş, Engin Koyuncu, İrfan Taşoğlu, Osman Tecimel, Neşe Özgirgin
Osteoarthritis (OA) is a low grade systemic inflammatory disease in which many inflammatory mediators are known to be elevated in the peripheric blood. Blood platelet lymphocyte ratio (PLR) and mean platelet volume (MPV) are accepted as novel markers in many of the systemic inflammatory disorders, but have not been investigated in synovitis-free radiographic OA yet.The aim of this study was to evaluate the levels of blood PLR and MPV in radiographic hip OA. A total of 880 patients were evaluated retrospectively and after certain exclusion criteria, 237 of them who have primary hip OA were included...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28173795/good-life-with-osteoarthritis-in-denmark-gla-d%C3%A2-evidence-based-education-and-supervised-neuromuscular-exercise-delivered-by-certified-physiotherapists-nationwide
#7
Søren T Skou, Ewa M Roos
BACKGROUND: The uptake of evidence-based guidelines in clinical practice is suboptimal in osteoarthritis (OA) and other chronic diseases. Good Life with osteoArthritis in Denmark (GLA:D) was launched in 2013 with the aim of implementing guidelines for the treatment of knee and hip OA in clinical care nationwide. The purpose of this report was to evaluate the effects of the GLA:D intervention from 2013 to 2015, using data from the national GLA:D registry. METHODS: Patients undergo education and supervised exercise delivered by trained physiotherapists...
February 7, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28167869/bearings-in-hip-arthroplasty-joint-registries-vs-precision-medicine-review-article
#8
REVIEW
Mark J Pearson, Liam M Grover, Janet M Lord, Simon W Jones, Edward T Davis
BACKGROUND: Precision medicine has been adopted in a range of clinical settings where omics data have led to greater characterisation of disease and stratification of patients into subcategories of phenotypes and pathologies. However, in orthopaedics, precision medicine lags behind other disciplines such as cancer. Joint registries have now amassed a huge body of data pertaining to implant performance which can be broken down into performance statistics for different material types in different cohorts of patients...
February 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28167387/hip-joint-mechanics-during-walking-in-individuals-with-mild-to-moderate-hip-osteoarthritis
#9
Maria Constantinou, Aderson Loureiro, Christopher Carty, Peter Mills, Rod Barrett
The purpose of this case-control study was to characterise hip joint kinematics and moments during gait in people with mild-to-moderate hip osteoarthritis (OA). Eligible participants were allocated to the hip OA group (n=27) or the age-matched control group (n=26) based on radiographic and symptomatically defined inclusion criteria. Participants walked barefoot along a 10-m walkway at their self-selected gait speed. Trajectories of 43 markers attached to the trunk, pelvis, upper and lower limbs were recorded using a 12-camera motion capture system...
January 24, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28153419/kinematic-alterations-of-the-lower-limbs-and-pelvis-during-an-ascending-stairs-task-are-associated-with-the-degree-of-knee-osteoarthritis-severity
#10
Glaucia Helena Gonçalves, Luiz Fernando Approbato Selistre, Marina Petrella, Stela Márcia Mattiello
BACKGROUND: Individuals with knee osteoarthritis (OA) generally demonstrate great difficulty in ascending stairs. The strategies and compensations used by these individuals in stair activities have not been fully established. The purpose of this study was to investigate the joint kinematics of the pelvis, hip, knee and ankle throughout the gait cycle, in the sagittal and frontal planes, in individuals with mild and moderate knee OA, during an ascending stairs task. METHODS: Thirty-one individuals with knee OA and 19 controls were subjected to clinical and radiographic analysis, divided into three groups: control, mild knee OA, and moderate knee OA...
January 30, 2017: Knee
https://www.readbyqxmd.com/read/28152269/lifetime-risk-of-primary-total-hip-replacement-surgery-for-osteoarthritis-from-2003-2013-a-multi-national-analysis-using-national-registry-data
#11
Ilana N Ackerman, Megan A Bohensky, Richard de Steiger, Caroline A Brand, Antti Eskelinen, Anne Marie Fenstad, Ove Furnes, Stephen E Graves, Jaason Haapakoski, Keijo Mäkelä, Frank Mehnert, Szilard Nemes, Søren Overgaard, Alma B Pedersen, Göran Garellick
OBJECTIVE: To compare the lifetime risk of total hip replacement surgery (THR) for osteoarthritis (OA) between countries, and over time. METHODS: Data on primary THR procedures performed for OA in 2003 and 2013 were extracted from national arthroplasty registries in Australia, Denmark, Finland, Norway and Sweden. Life tables and population data were also obtained for each country. Lifetime risk of THR was calculated for 2003 and 2013 using registry, life table and population data...
February 2, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28150871/osteoarthritis-and-joint-replacements-of-the-lower-limb-and-spine-in-ex-professional-soccer-players-a-systematic-review
#12
REVIEW
Monika Lohkamp, Thilo Oliver Kromer, Holger Schmitt
After a professional career as a soccer player, the risk of developing osteoarthritis (OA) in different joints of the spine and lower limb might be increased. The extent of this problem to date is not clear. Therefore, the aim of this systematic review is to summarise the prevalence of OA and joint replacement of the lower limb and spine in former professional soccer players. Relevant databases were searched with different combinations of key words: e.g. osteoarthritis, hip, knee, ankle, foot, joint replacement, soccer...
February 2, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28144573/glucosamine-and-chondroitin-for-the-treatment-of-osteoarthritis
#13
EDITORIAL
Haris S Vasiliadis, Konstantinos Tsikopoulos
The prevalence of primary or idiopathic osteoarthritis (OA) of knee and hip joints has substantially increased in general population during the last decades. Analgesics and non-steroidal anti-inflammatory drugs are currently extensively used as non-surgical treatment options. However, they act as symptomatic treatments, not offering a cure of OA and they are accused for an increased risk of adverse events. Glucosamine (GL) and chondroitin (CH) are nutritional supplements that have recently gained widespread use as treatment options for OA...
January 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28142365/hip-and-knee-osteoarthritis-affects-younger-people-too
#14
Ilana N Ackerman, Joanne L Kemp, Kay M Crossley, Adam G Culvenor, Rana S Hinman
Synopsis Although osteoarthritis (OA) has traditionally been considered a disease of older age, hip and knee OA can and does affect younger adults, with a profound impact on psychosocial well-being and work capacity. Obesity and a history of traumatic knee injury (eg, anterior cruciate ligament rupture and/or meniscal tear) are key risk factors for the accelerated development of knee OA, while structural hip deformities (including those contributing to femoroacetabular impingement syndrome) are strong predictors of early-onset hip OA...
February 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28141914/exercise-for-hand-osteoarthritis
#15
REVIEW
Nina Østerås, Ingvild Kjeken, Geir Smedslund, Rikke H Moe, Barbara Slatkowsky-Christensen, Till Uhlig, Kåre Birger Hagen
BACKGROUND: Hand osteoarthritis (OA) is a prevalent joint disease that may lead to pain, stiffness and problems in performing hand-related activities of daily living. Currently, no cure for OA is known, and non-pharmacological modalities are recommended as first-line care. A positive effect of exercise in hip and knee OA has been documented, but the effect of exercise on hand OA remains uncertain. OBJECTIVES: To assess the benefits and harms of exercise compared with other interventions, including placebo or no intervention, in people with hand OA...
January 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28137249/multiplanar-evaluation-of-radiological-findings-associated-with-acetabular-dysplasia-and-investigation-of-its-prevalence-in-an-asian-population-a-ct-based-study
#16
Tomohiro Mimura, Kanji Mori, Masahiro Kitagawa, Mariko Ueki, Yuki Furuya, Taku Kawasaki, Shinji Imai
BACKGROUND: Acetabular dysplasia (AD) is a well-known cause of osteoarthritis (OA) of the hip, with its prevalence previously determined on plain radiography. The prevalence of preexisting AD was reported as 7.3% in a patient-based Asian population. Although computed tomography (CT) could evaluate AD in multiple planes, its prevalence using multiplanar CT images has not been reported. We investigated its prevalence with CT on coronal, axial, and sagittal planes and then determined if adding the axial and sagittal planes enhanced the investigation...
January 31, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28134596/efficacy-and-safety-study-on-a-new-compound-associating-low-and-high-molecular-weight-hyaluronic-acid-in-the-treatment-of-hip-osteoarthritis
#17
Michele Abate, Vincenzo Salini
The combined use of low and high molecular weight hyaluronic acid (HA) has never been reported in the treatment of osteoarthritis (OA). The aim of this paper was to evaluate the efficacy of a new hybrid association of both preparations in patients suffering from hip OA and to compare the results with those obtained retrospectively from a cohort of patients treated with high molecular weight HA. Twenty patients with moderate-severe hip OA (grade II-IV according to Kellgren-Lawrence score) were enrolled in the study group...
January 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28129489/bone-mineral-density-and-the-risk-of-hip-and-knee-osteoarthritis-the-johnston-county-osteoarthritis-project
#18
Kamil E Barbour, Louise B Murphy, Charles G Helmick, Jennifer M Hootman, Jordan B Renner, Joanne M Jordan
OBJECTIVES: To address knowledge gaps regarding the relationship between bone mineral density (BMD) and incident hip or knee osteoarthritis (OA); specifically, lack of information regarding hip OA or symptomatic outcomes. METHODS: Using data (N=1,474) from the Johnston County Osteoarthritis (JoCo OA) Project's first (1999-2004) and second follow-up (2005-2010) of participants aged ≥45 years we examined the association between total hip BMD and both hip and knee OA...
January 27, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28123640/microrna-410-promotes-chondrogenic-differentiation-of-human-bone-marrow-mesenchymal-stem-cells-through-down-regulating-wnt3a
#19
Yanjie Zhang, Xiaohan Huang, Yanhao Yuan
BACKGROUND: Chondrogenic differentiation of mesenchymal stem cells (MSCs) is important for osteoarthritis (OA) treatment. However, the specific mechanisms involved are undefined. MicroRNAs (miRNAs) downregulate protein synthesis by binding to the 3'UTR of target mRNA. METHODS: Bone marrow aspirates were obtained from OA patients undergoing total hip arthroplasty (n=8) to isolate MSCs. MiR-410 or miR-410 inhibitor were transfected into MSCs using lentivirus and the effects were assessed...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28116214/exercise-training-in-treatment-and-rehabilitation-of-hip-osteoarthritis-a-12-week-pilot-trial
#20
Kirsti Uusi-Rasi, Radhika Patil, Saija Karinkanta, Kari Tokola, Pekka Kannus, Harri Sievänen
Introduction. Osteoarthritis (OA) of the hip is one of the major causes of pain and disability in the older population. Although exercise is an effective treatment for knee OA, there is lack of evidence regarding hip OA. The aim of this trial was to test the safety and feasibility of a specifically designed exercise program in relieving hip pain and improving function in hip OA participants and to evaluate various methods to measure changes in their physical functioning. Materials and Methods. 13 women aged ≥ 65 years with hip OA were recruited in this 12-week pilot study...
2017: Journal of Osteoporosis
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