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https://www.readbyqxmd.com/read/29773173/gene-expression-in-adverse-reaction-to-metal-debris-around-metal-on-metal-arthroplasty-an-rna-seq-based-study
#1
Antti Pemmari, Tiina Leppänen, Erja-Leena Paukkeri, Antti Eskelinen, Teemu Moilanen, Eeva Moilanen
Joint replacement surgery is a standard treatment of advanced osteoarthritis (OA). Since 2000, cobalt-chromium (CoCr) metal-on-metal (MoM) implants were widely used in hip arthroplasties. Some patients developed "adverse reaction to metal debris" (ARMD) around the prosthesis, resulting in a need for revision surgery. In the present study, we addressed the pathogenesis of ARMD by genome-wide expression analysis. Pseudosynovial ARMD tissue was obtained from revision surgery of Articular Surface Replacement (ASR, DePuy, Warsaw, IN, USA) hip arthroplasties...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29760167/factors-associated-with-pain-and-osteoarthritis-at-the-hip-and-knee-in-great-britain-s-olympians-a-cross-sectional-study
#2
Dale J Cooper, Brigitte E Scammell, Mark E Batt, Debbie Palmer
BACKGROUND: Knowledge of the epidemiology and potentially modifiable factors associated with musculoskeletal disease is an important first step in injury prevention among elite athletes. AIM: This study investigated the prevalence and factors associated with pain and osteoarthritis (OA) at the hip and knee in Great Britain's (GB) Olympians aged 40 and older. METHODS: This is a cross-sectional study. A survey was distributed to 2742 GB Olympians living in 30 countries...
May 14, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29758361/bone-accrual-in-oligo-amenorrheic-athletes-eumenorrheic-athletes-and-non-athletes
#3
Vibha Singhal, Karen Campoverde Reyes, Brooke Pfister, Kathryn Ackerman, Meghan Slattery, Katherine Cooper, Alexander Toth, Nupur Gupta, Mark Goldstein, Kamryn Eddy, Madhusmita Misra
BACKGROUND: Mechanical loading improves bone mineral density (BMD) and strength while decreasing fracture risk. Cross-sectional studies show that exercise advantage is lost in oligo-amenorrheic athletes (OA). Longitudinal studies examining the opposing effects of exercise and hypogonadism on bone are lacking in adolescents/young adults. OBJECTIVE: Evaluate differences in bone accrual over 12 months in OA, eumenorrheic athletes (EA) and non-athletes (NA). We hypothesized that bone accrual would be lower in OA than EA and NA, with differences most pronounced at non-weight bearing trabecular sites...
May 11, 2018: Bone
https://www.readbyqxmd.com/read/29758352/prospective-associations-of-c-reactive-protein-crp-levels-and-crp-genetic-risk-scores-with-risk-of-total-knee-and-hip-replacement-for-osteoarthritis-in-a-diverse-cohort
#4
Aladdin H Shadyab, Robert Terkeltaub, Charles Kooperberg, Alexander Reiner, Charles B Eaton, Rebecca D Jackson, Jessica L Krok-Schoen, Rany M Salem, Andrea Z LaCroix
OBJECTIVE: To examine associations of high-sensitivity C-reactive protein (CRP) levels and polygenic CRP genetic risk scores (GRS) with risk of end-stage hip or knee osteoarthritis (OA), defined as incident total hip (THR) or knee replacement (TKR) for OA. DESIGN: This study included a cohort of postmenopausal white, African American, and Hispanic women from the Women's Health Initiative. Women were followed from baseline to date of THR or TKR, death, or December 31, 2014...
May 11, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29744608/a-theory-of-planned-behavior-based-intervention-to-improve-quality-of-life-in-patients-with-knee-hip-osteoarthritis-a-randomized-controlled-trial
#5
Mohsen Saffari, Mohammad Kazem Emami Meybodi, Hormoz Sanaeinasab, Ali Karami, Amir H Pakpour, Harold G Koenig
Osteoarthritis (OA) is a common chronic disorder among elderly people that affects joints such as the knee and hip in particular. The objective of the current study was to examine the efficacy of an intervention based on a theory of planned behavior (TPB) in improving health-related quality of life in middle-age and older adults with this condition. One hundred twenty patients diagnosed with knee/hip OA were recruited from a general hospital. Measures administered at baseline were the SF-12, EuroQol (EQ-5D), Osteoarthritis Knee and Hip Quality of Life (OAKHQoL), and TPB questionnaire...
May 10, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29741735/widespread-epigenomic-transcriptomic-and-proteomic-differences-between-hip-osteophytic-and-articular-chondrocytes-in-osteoarthritis
#6
Julia Steinberg, Roger A Brooks, Lorraine Southam, Sahir Bhatnagar, Theodoros I Roumeliotis, Konstantinos Hatzikotoulas, Eleni Zengini, J Mark Wilkinson, Jyoti S Choudhary, Andrew W McCaskie, Eleftheria Zeggini
Objectives: To identify molecular differences between chondrocytes from osteophytic and articular cartilage tissue from OA patients. Methods: We investigated genes and pathways by combining genome-wide DNA methylation, RNA sequencing and quantitative proteomics in isolated primary chondrocytes from the cartilaginous layer of osteophytes and matched areas of low- and high-grade articular cartilage across nine patients with OA undergoing hip replacement surgery. Results: Chondrocytes from osteophytic cartilage showed widespread differences to low-grade articular cartilage chondrocytes...
May 8, 2018: Rheumatology
https://www.readbyqxmd.com/read/29739632/outcomes-and-factors-influencing-response-to-an-individualized-multidisciplinary-chronic-disease-management-program-for-hip-and-knee-osteoarthritis
#7
David P Gwynne-Jones, Andrew R Gray, Liam R Hutton, Kirsten M Stout, J Haxby Abbott
BACKGROUND: The objective of the study was to investigate the effectiveness of, and factors associated with, response to a chronic disease management program for patients with hip and knee osteoarthritis (OA). METHODS: Over a 2-year period (2012-2014), 218 patients (97 hip OA; 121 knee OA) were managed with an individualized program of interventions that could include education, physiotherapy, orthotics, occupational therapy, or dietitian referral. Changes in Oxford Hip Score or Oxford Knee Score and Short Form-12 (SF-12) Physical and Mental Component Summary Score (PCS, MCS) were analyzed by joint affected, both unadjusted, and gender and age adjusted...
April 16, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29734841/gait-asymmetries-in-unilateral-symptomatic-hip-osteoarthritis-and-their-association-with-radiographic-severity-and-pain
#8
Gary J Farkas, Bryan R Schlink, Louis F Fogg, Kharma C Foucher, Markus A Wimmer, Najia Shakoor
INTRODUCTION: Little is known about the loading patterns in unilateral hip osteoarthritis (OA) and their relationship to radiographic severity and pain. We aimed to examine the loading patterns at the hips of those with unilateral symptomatic hip OA and identify associations between radiographic severity and pain with loading alterations. METHODS: Sixty-one subjects with symptomatic unilateral hip OA underwent gait analyses and evaluation for radiographic severity (Kellgren-Lawrence [KL]-grade) and pain (visual analogue scale) at bilateral hips...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29734501/using-multidimensional-topological-data-analysis-to-identify-traits-of-hip-osteoarthritis
#9
Jasmine Rossi-deVries, Valentina Pedoia, Michael A Samaan, Adam R Ferguson, Richard B Souza, Sharmila Majumdar
BACKGROUND: Osteoarthritis (OA) is a multifaceted disease with many variables affecting diagnosis and progression. Topological data analysis (TDA) is a state-of-the-art big data analytics tool that can combine all variables into multidimensional space. TDA is used to simultaneously analyze imaging and gait analysis techniques. PURPOSE: To identify biochemical and biomechanical biomarkers able to classify different disease progression phenotypes in subjects with and without radiographic signs of hip OA...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29732726/functional-characterisation-of-the-osteoarthritis-genetic-risk-residing-at-aldh1a2-identifies-rs12915901-as-a-key-target-variant
#10
Colin Shepherd, Dongxing Zhu, Andrew J Skelton, Jennifer Combe, Harrison Threadgold, Linyi Zhu, Tonia L Vincent, Paul Stuart, Louise N Reynard, John Loughlin
OBJECTIVE: To identify the functional single nucleotide polymorphisms (SNPs) and mechanisms conferring increased hand osteoarthritis (OA) risk at the ALDH1A2 locus, which is a retinoic acid (RA) regulatory gene. METHODS: Tissues from 247 knee, hip or hand OA patients who had undergone joint surgery were included. RNA-sequencing was used to investigate differential expression of ALDH1A2 and other RA signalling pathway genes in cartilage. ALDH1A2 expression in multiple joint tissues was quantified by qPCR...
May 6, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29729027/acupuncture-for-hip-osteoarthritis
#11
REVIEW
Eric Manheimer, Ke Cheng, L Susan Wieland, Xueyong Shen, Lixing Lao, Menghu Guo, Brian M Berman
BACKGROUND: Hip osteoarthritis (OA) is a major cause of pain and functional limitation. Few hip OA treatments have been evaluated for safety and effectiveness. Acupuncture is a traditional Chinese medical therapy which aims to treat disease by inserting very thin needles at specific points on the body. OBJECTIVES: To assess the benefits and harms of acupuncture in patients with hip OA. SEARCH METHODS: We searched Cochrane CENTRAL, MEDLINE, and Embase all through March 2018...
May 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29713415/spinopelvic-alignment-and-low-back-pain-after-total-hip-replacement-arthroplasty-in-patients-with-severe-hip-osteoarthritis
#12
Yawara Eguchi, Satoshi Iida, Chiho Suzuki, Yoshiyuki Shinada, Tomoko Shoji, Kazuhisa Takahashi, Seiji Ohtori
Study Design: Retrospective observational study. Purpose: We examined change in lumbrosacral spine alignment and low back pain (LBP) following total hip arthroplasty (THA) in patients with severe hip osteoarthritis (OA). Overview of Literature: Severe hip osteoarthritis has been reported to cause spine alignment abnormalities and low back pain, and it has been reported that low back pain is improved following THA. Methods: Our target population included 30 patients (29 female, mean age 63...
April 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29704023/radiological-analysis-of-cystic-lesion-in-osteonecrosis-of-the-femoral-head
#13
Fuqiang Gao, Jun Han, Zike He, Zirong Li
PURPOSE: Cystic lesions are a common complication in osteonecrosis of the femoral head (ONFH). This study will discuss the cause of cystic lesion formation and the feature of cystic lesion distribution in ONFH. According to the feature of cystic lesion in ONFH, we will discuss the possible mechanisms of cystic lesions and their  influence on collapse of the femoral head. MATERIALS AND METHODS: We retrospectively gathered 102 ONFH patients (168 hips) from November in 2015 to August in 2016 on China-Japan Friendship Hospital...
April 27, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29701488/effectiveness-of-a-dietary-supplement-containing-hydrolyzed-collagen-chondroitin-sulfate-and-glucosamine-in-pain-reduction-and-functional-capacity-in-osteoarthritis-patients
#14
Jordi Puigdellivol, Carme Comellas Berenger, Miguel Ángel Pérez Fernández, Juan M Cowalinsky Millán, Christian Carreras Vidal, Inés Gil Gil, Julio Martínez Pagán, Borja Ruiz Nieto, Francisco Jiménez Gómez, Francesc X Comas Figuerola, María E Aguilar Hernández
This observational, open, multicenter clinical trial with a single treatment group aimed to evaluate the effectiveness of a dietary supplement whose main ingredients are hydrolyzed gelatin, chondroitin sulfate, glucosamine sulfate, and devil's claw and bamboo extracts for pain reduction and improvement of functional capacities in patients with osteoarthritis (OA) of the knee and/or hip (REDART study). In all, 130 patients with OA recruited from Spanish hospitals received the dietary supplement for 6 months...
April 27, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29701094/patient-reported-outcome-measures-after-surgery-for-an-acetabular-fracture
#15
B Frietman, J Biert, M J R Edwards
Aims The aim of this study was to record the incidence of post-traumatic osteoarthritis (OA), the need for total hip arthroplasty (THA), and patient-reported outcome measures (PROMS) after surgery for a fracture of the acetabulum, in our centre. Patients and Methods All patients who underwent surgery for an acetabular fracture between 2004 and 2014 were included. Patients completed the 36-Item Short Form Health Survey (SF-36) and the modified Harris Hip Score (mHHS) questionnaires. A retrospective chart and radiographic review was performed on all patients...
May 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29700988/leg-length-inequality-and-hip-osteoarthritis-in-the-multicenter-osteoarthritis-study-and-the-osteoarthritis-initiative
#16
Chan Kim, Michael Nevitt, Ali Guermazi, Jingbo Niu, Margaret Clancy, Irina Tolstykh, Pia M Jungmann, Nancy E Lane, Neil A Segal, Wiiliam F Harvey, Cora E Lewis, David T Felson
OBJECTIVE: Studies suggest that persons with a 2 cm shorter limb have an increased risk of knee osteoarthritis (OA) in that limb. We examined whether leg length inequality (LLI) confers an increased risk of hip OA. METHODS: Using long limb radiographs from MOST and the Osteoarthritis Initiative, we measured LLI and scored hip radiographs which were obtained at baseline and 3-5 year follow-up. We examined the association of >1 cm LLI and >2 cm of LLI with radiographic hip OA cross-sectionally and longitudinally, assessing risk in shorter limbs and longer limbs compared with limbs with no LLI...
April 26, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29698301/is-there-an-association-between-borderline-to-mild-dysplasia-and-hip-osteoarthritis-analysis-of-ct-osteoabsorptiometry
#17
Tohru Irie, Daisuke Takahashi, Tsuyoshi Asano, Ryuta Arai, Muhammad Alaa Terkawi, Yoichi M Ito, Norimasa Iwasaki
BACKGROUND: The definitive treatment of borderline-to-mild dysplasia remains controversial. A more comprehensive understanding of the etiology of osteoarthritis (OA) and clarification of any possible association between borderline-to-mild dysplasia and the pathogenesis of OA are essential. QUESTIONS/PURPOSES: (1) Does the distribution of acetabular subchondral bone density increase according to dysplasia severity? (2) Is there an association between borderline-to-mild dysplasia and OA pathogenesis? METHODS: We evaluated bilateral hips of patients with developmental dysplasia of the hip who underwent eccentric rotational acetabular osteotomy (ERAO) for inclusion in the dysplasia group and contralateral hips of patients with unilateral idiopathic osteonecrosis of the femoral head (ONFH) who underwent curved intertrochanteric varus osteotomy (CVO) for the control group...
April 23, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29683803/is-cemented-or-cementless-femoral-stem-fixation-more-durable-in-patients-older-than-75-years-of-age-a-comparison-of-the-best-performing-stems
#18
Michael Tanzer, Stephen E Graves, Andrea Peng, Andrew J Shimmin
BACKGROUND: There is ongoing debate concerning the best method of femoral fixation in older patients receiving primary THA. Clinical studies have shown high survivorship for cemented and cementless femoral stems. Arthroplasty registry studies, however, have universally shown that cementless stems are associated with a higher rate of revision in this patient population. It is unclear if the difference in revision rate is a reflection of the range of implants being used for these procedures rather than the mode of fixation...
April 9, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29674847/good-function-and-high-patient-satisfaction-at-mean-2-8-years-after-dual-mobility-tha-following-femoral-neck-fracture-a-cross-sectional-study-of-124-patients
#19
Steffan Tabori-Jensen, Torben B Hansen, Søren Bøvling, Peter Aalund, Morten Homilius, Maiken Stilling
Aims: Our aim was to investigate function, health status and satisfaction in patients treated with primary dual mobility (DM) total hip arthroplasty (THA) after displaced femoral neck fracture (FNF). Patients and methods: From 2005-2011, 414 consecutive FNF patients received Saturne DM THA. At a minimum of 1-year follow-up, 124 (95 women) were evaluated with Oxford Hip Score (OHS), Harris Hip Score (HHS), health-related quality of life (HRQoL) measure (EQ-5D) and two functional tests: Timed Up and Go (TUG) and Sit to Stand 10 times (STS)...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29673866/significant-morphological-change-in-osteoarthritic-hips-identified-over-6-12-months-using-statistical-shape-modelling
#20
Rebecca J Barr, Jennifer S Gregory, Kanako Yoshida, Salvatore Alesci, Richard M Aspden, David M Reid
OBJECTIVE: Predicting who will develop osteoarthritis, assessing how rapidly their disease will progress and monitoring early responses to treatment are key to the development of therapeutic agents able to treat this crippling disease and to their future clinical use. Statistical Shape Modelling (SSM) enables quantification of variations in multiple geometric measures describing the whole hip joint to be considered in concert. This prospective study evaluates the responsiveness of SSM to changes in hip-shape within one year...
April 16, 2018: Osteoarthritis and Cartilage
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