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https://www.readbyqxmd.com/read/29552305/-muc16-overexpression-induced-by-gene-mutations-promotes-lung-cancer-cell-growth-and-invasion
#1
Madiha Kanwal, Xiao-Jie Ding, Xin Song, Guang-Biao Zhou, Yi Cao
Air pollution is one of the leading causes of lung cancer. Air pollution-related lung cancer is a deteriorating public health problem, particularly in developing countries. The MUC16 gene is one of the most frequently mutated genes in air pollution-related lung cancer. In the present study, MUC16 mRNA expression was increased in ∼50% of air pollution-related lung cancer samples obtained from patients residing in air-polluted regions (Xuanwei and Fuyuan, Yunnan, China), and MUC16 mRNA levels were correlated with the degree of air pollution...
February 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29391232/multifunctional-nanoparticles-for-cancer-immunotherapy-a-groundbreaking-approach-for-reprogramming-malfunctioned-tumor-environment
#2
REVIEW
Samaresh Sau, Hashem O Alsaab, Ketki Bhise, Rami Alzhrani, Ghazal Nabil, Arun K Iyer
Several cancer immunotherapy approaches have been recently introduced into the clinics and they have shown remarkable therapeutic potentials. The groundbreaking cancer immunotherapeutic agents function as a stimulant or modulator of the body immune system to fight against or kill cancers. Although targeted immunotherapies such as immune check point inhibitors (CTLA-4 or PD-1/PD-L1), DNA vaccination and CAR-T therapy are revolutionizing cancer treatment, the delivery efficacy can be further improved while their off-target toxicity can be mitigated through nanotechnology approaches...
March 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29183134/in-vitro-transduction-and-target-mutagenesis-efficiency-of-hiv-1-pol-gene-targeting-zfn-and-crispr-cas9-delivered-by-various-plasmids-and-or-vectors-toward-an-hiv-cure
#3
Moses Okee, Alice Bayiyana, Carol Musubika, Moses L Joloba, Fred Ashaba-Katabazi, Bernard Bagaya, Misaki Wayengera
Efficiency of artificial restriction enzymes toward curing HIV has only been separately examined, using differing delivery vehicles. We compared the in vitro transduction and target-mutagenesis efficiency of consortium plasmid and adenoviral vector delivered HIV-1 pol gene targeting zinc finger nuclease (ZFN) with CRISPR/Cas, Custom-ZFN, CRISPR-Cas-9, and plasmids and vectors (murCTSD_pZFN, pGS-U-gRNA, pCMV-Cas-D01A, Ad5-RGD); cell lines (TZM-bl and ACH-2/J-Lat cells); and the latency reversing agents prostratin, suberoylanilide hydroxamic acid, and phorbol myristate acetate...
January 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29116883/the-elusive-search-for-reniform-nematode-resistance-in-cotton
#4
Churamani Khanal, Edward C McGawley, Charles Overstreet, Salliana R Stetina
The reniform nematode (Rotylenchulus reniformis Linford and Oliveira) has emerged as the most important plant-parasitic nematode of cotton in the United States cotton belt. Success in the development of reniform nematode-resistant upland cotton cultivars (Gossypium hirsutum L.) has not been realized despite over three decades of breeding efforts. Research approaches ranging from conventional breeding to triple species hybrids to marker-assisted selection have been employed to introgress reniform nematode resistance from other species of cotton into upland cultivars...
May 2018: Phytopathology
https://www.readbyqxmd.com/read/27642089/foreign-dna-acquisition-by-invertebrate-genomes
#5
REVIEW
J-M Drezen, J Gauthier, T Josse, A Bézier, E Herniou, E Huguet
Recent studies have highlighted that the accidental acquisition of DNA from other species by invertebrate genomes is much more common than originally thought. The transferred DNAs are of bacterial or eukaryote origin and in both cases the receiver species may end up utilising the transferred genes for its own benefit. Frequent contact with prokaryotic DNA from symbiotic endocellular bacteria may predispose invertebrates to incorporate this genetic material into their genomes. Increasing evidence also points to viruses as major players in transferring genes and mobile elements between the species they infect...
July 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/25948376/nanomedicine-as-an-emerging-platform-for-metastatic-lung-cancer-therapy
#6
REVIEW
Dalit Landesman-Milo, Srinivas Ramishetti, Dan Peer
Metastatic lung cancer is one of the most common cancers leading to mortality worldwide. Current treatment includes chemo- and pathway-dependent therapy aiming at blocking the spread and proliferation of these metastatic lesions. Nanomedicine is an emerging multidisciplinary field that offers unprecedented access to living cells and promises the state of the art in cancer detection and treatment. Development of nanomedicines as drug carriers (nanocarriers) that target cancer for therapy draws upon principles in the fields of chemistry, medicine, physics, biology, and engineering...
June 2015: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/25748161/3-anhydro-6-hydroxy-ophiobolin-a-a-fungal-sesterterpene-from-bipolaris-oryzae-induced-autophagy-and-promoted-the-degradation-of-%C3%AE-synuclein-in-pc12-cells
#7
Danfeng Xue, Quanxin Wang, Ziheng Chen, Lei Cai, Li Bao, Qiuyue Qi, Lei Liu, Xiaohui Wang, Haijing Jin, Jun Wang, Hao Wu, Hongwei Liu, Quan Chen
Autophagy is defined as an evolutionarily conserved process responsible for degradation of the cytoplasmic components including protein aggregates via the lysosomal machinery. Increasing evidence has linked defective autophagic degradation of protein aggregates with the pathogenesis of neurodegenerative disorders, and it is suggested that promotion of autophagy is regarded as a potential therapeutic for these diseases including Parkinson's disease (PD). Here we identified, 3-anhydro-6-hydroxy-ophiobolin A (X15-2), an ophiobolin derivative from Bipolaris oryzae that can strongly induce autophagic degradation of α-synuclein, the major constituent of Lewy bodies...
April 1, 2015: Bioorganic & Medicinal Chemistry Letters
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