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Tiziana Quarto, Isabella Paparella, Davide De Tullio, Giovanna Viscanti, Leonardo Fazio, Paolo Taurisano, Raffaella Romano, Antonio Rampino, Rita Masellis, Teresa Popolizio, Pierluigi Selvaggi, Giulio Pergola, Alessandro Bertolino, Giuseppe Blasi
The brain functional mechanisms translating genetic risk into emotional symptoms in schizophrenia (SCZ) may include abnormal functional integration between areas key for emotion processing, such as the amygdala and the lateral prefrontal cortex (LPFC). Indeed, investigation of these mechanisms is also complicated by emotion processing comprising different subcomponents and by disease-associated state variables. Here, our aim was to investigate the relationship between risk for SCZ and effective connectivity between the amygdala and the LPFC during different subcomponents of emotion processing...
September 16, 2017: Schizophrenia Bulletin
Matthijs Vink, Max de Leeuw, Jurjen J Luykx, Kristel R van Eijk, Hanna E van den Munkhof, Mariët van Buuren, René S Kahn
A recent Genome-Wide Association Study showed that the rs2514218 single nucleotide polymorphism (SNP) in close proximity to dopamine receptor D2 is strongly associated with schizophrenia. Further, an in silico experiment showed that rs2514218 has a cis expression quantitative trait locus effect in the basal ganglia. To date, however, the functional consequence of this SNP is unknown. Here, we used functional Magnetic resonance imaging to investigate the impact of this risk allele on striatal activation during proactive and reactive response inhibition in 45 unaffected siblings of schizophrenia patients...
May 2016: Schizophrenia Bulletin
Jian-Ping Zhang, Delbert G Robinson, Juan A Gallego, Majnu John, Jin Yu, Jean Addington, Mauricio Tohen, John M Kane, Anil K Malhotra, Todd Lencz
Findings from the Psychiatric Genomics Consortium genome-wide association study (GWAS) showed that variation at the DRD2 locus is associated with schizophrenia risk. However, the functional significance of rs2514218, the top DRD2 single nucleotide polymorphism in the GWAS, is unknown. Dopamine D2 receptor binding is a common mechanism of action for all antipsychotic drugs, and DRD2 variants were related to antipsychotic response in previous studies. The present study examined whether rs2514218 genotype could predict antipsychotic response, including efficacy and adverse events, in a cohort of patients with first episode of psychosis treated with either risperidone or aripiprazole for 12 weeks...
November 2015: Schizophrenia Bulletin
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