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https://www.readbyqxmd.com/read/29454288/apocynum-venetum-leaf-extract-reverses-depressive-like-behaviors-in-chronically-stressed-rats-by-inhibiting-oxidative-stress-and-apoptosis
#1
Xiangting Li, Ting Wu, Zhonghai Yu, Tingting Li, Jingsi Zhang, Zhennian Zhang, Min Cai, Wen Zhang, Jun Xiang, Dingfang Cai
BACKGROUND: Major depressive disorder (MDD) is a common but serious psychiatric disorder, but current treatments are inadequate for approximately half of the patients with MDD. Thus, better methods of treatment are urgently needed. This study aimed to investigate the antidepressant-like effects and potential mechanism of Apocynum venetum leaf extract (AVLE) in chronic unpredictable mild stress (CUMS) rat model of depression. MATERIALS AND METHODS: The CUMS rat model of depression was used to investigate the antidepressant-like activity and relevant mechanism of AVLE (30, 60, and 125 mg/kg, i...
February 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29454270/cadmium-induced-stress-response-of-phanerochaete-chrysosporium-during-the-biodegradation-of-2-2-4-4-tetrabromodiphenyl-ether-bde-47
#2
Mi Feng, Hua Yin, Yajuan Cao, Hui Peng, Guining Lu, Zehua Liu, Zhi Dang
Cd-induced stress response of Phanerochaete chrysosporium during the biodegradation of BDE-47 was investigated in this study, with the goal of elucidating the tolerance behavior and the detoxification mechanisms of P. chrysosporium to resist the Cd stress in the course of BDE-47 biodegradation, which has implications for expanding the application of P. chrysosporium in the bioremediation of Cd and BDE-47 combined pollution. The results suggested that single BDE-47 exposure did not induce obvious oxidative stress in P...
February 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29454241/frailty-and-life-course-violence-the-international-mobility-in-aging-study
#3
Cristiano Dos Santos Gomes, Catherine McLean Pirkle, Maria Vitoria Zunzunegui, Dimitri Taurino Guedes, Juliana Fernandes De Souza Barbosa, Phoebe Hwang, Ricardo Oliveira Guerra
OBJECTIVE: To estimate the prevalence of frailty in older adults in the IMIAS population, to examine associations between lifelong domestic violence and frailty and possible pathways to explain these associations. METHODS: A cross-sectional study with 2002 men and women in the International Mobility in Aging Study, aged between 65 and 74 years old living in five cities of Tirana (Albania), Natal (Brazil), Kingston and Saint-Hyacinthe (Canada), and Manizales (Colombia)...
February 8, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29454221/-13-c-phenylalanine-breath-test-and-serum-biopterin-in-schizophrenia-bipolar-disorder-and-major-depressive-disorder
#4
Toshiya Teraishi, Masahiro Kajiwara, Hiroaki Hori, Daimei Sasayama, Shinsuke Hidese, Junko Matsuo, Ikki Ishida, Yasuhiro Kajiwara, Yuji Ozeki, Miho Ota, Kotaro Hattori, Teruhiko Higuchi, Hiroshi Kunugi
Phenylalanine is required for the synthesis of the neurotransmitters dopamine, noradrenaline, and adrenaline. The rate-limiting step for phenylalanine metabolism is catalyzed by phenylalanine hydroxylase (PAH) and its cofactor tetrahydrobiopterin. We aimed to detect altered phenylalanine metabolism in major psychiatric disorders using the l-[1- 13 C]phenylalanine breath test ( 13 C-PBT) and serum biopterin levels. We also investigated association of PAH mutations with schizophrenia and phenylalanine metabolism...
February 3, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29454180/tryptophan-kynurenine-and-lipid-related-metabolites-as-blood-biomarkers-for-first-episode-drug-na%C3%A3-ve-patients-with-major-depressive-disorder-an-exploratory-pilot-case-control-study
#5
Nobuki Kuwano, Takahiro A Kato, Daiki Setoyama, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Masahiro Ohgidani, Noriaki Sagata, Hiroaki Kubo, Junji Kishimoto, Dongchon Kang, Shigenob Kanba
BACKGROUND: Early intervention in depression has been critical to prevent its negative impact including suicide. Recent blood biomarker studies for major depressive disorder (MDD) have suggested that tryptophan-kynurenine and lipid related metabolites are involved in the pathophysiology of MDD. However, there have been limited studies investigating these blood biomarkers in first-episode drug-naïve MDD, which are particularly important for early intervention in depression. METHODS: As an exploratory pilot case-control study, we examined the above blood biomarkers, and analyzed how these biomarkers are associated with clinical variables in first-episode drug-naïve MDD patients, based on metabolome/lipidome analysis...
January 31, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29454165/pituitary-gland-shrinkage-in-bipolar-disorder-the-role-of-gender
#6
Giuseppe Delvecchio, Gian Mario Mandolini, Cinzia Perlini, Marco Barillari, Veronica Marinelli, Mirella Ruggeri, A Carlo Altamura, Marcella Bellani, Paolo Brambilla
BACKGROUND: Hyperactivity of the Hypothalamic-Pituitary-Adrenal Axis (HPAA) has been consistently reported in mood disorders. However, only few studies investigated the Pituitary gland (PG) in Bipolar Disorder (BD) and the results are so far contrasting. Therefore, the aim of this study is to explore the integrity of the PG as well as the role of gender and the impact of clinical measurements on this structure in a sample of BD patients compared to healthy controls (HC). METHODS: 34 BD patients and 41 HC underwent a 1...
February 14, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29454164/self-reported-inhibition-predicts-history-of-suicide-attempts-in-bipolar-disorder-and-major-depression
#7
André Ponsoni, Laura Damiani Branco, Charles Cotrena, Flávio Milman Shansis, Rodrigo Grassi-Oliveira, Rochele Paz Fonseca
BACKGROUND: Studies have reliably identified an association between suicide attempts and executive functions such as decision making (DM) and inhibitory control (IC) in patients with mood disorders. As such, the present study aimed to investigate the association between inhibition, DM, impulsivity and the history of suicide attempts in individuals with bipolar (BD) or major depressive disorder (MDD), identifying which assessment instruments may be most strongly associated with suicide in clinical samples...
February 14, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29454162/anxiety-depression-and-asthma-control-changes-after-standardized-treatment
#8
Joaquin Sastre, Astrid Crespo, Toni Fernandez-Sanchez, Manuel Rial, Vicente Plaza
BACKGROUND: It has been documented that anxiety and depression are prevalent in patients with asthma and are associated with greater frequency of exacerbations, increased use of health-care resources, and poor asthma control. OBJECTIVES: Our study examined not only the association of asthma diagnosis with symptoms of depression/anxiety and asthma control at baseline, but also over a 6-month period of specialist supervision. METHODS: We enrolled 3,182 patients with moderate-severe asthma...
February 14, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29454034/add-on-high-frequency-deep-transcranial-magnetic-stimulation-dtms-to-bilateral-prefrontal-cortex-in-depressive-episodes-of-patients-with-major-depressive-disorder-bipolar-disorder-i-and-major-depressive-with-alcohol-use-disorders
#9
Chiara Rapinesi, Georgios D Kotzalidis, Stefano Ferracuti, Nicoletta Girardi, Abraham Zangen, Gabriele Sani, Ruggero N Raccah, Paolo Girardi, Maurizio Pompili, Antonio Del Casale
BACKGROUND: Dorsolateral prefrontal cortex (DLPFC) is critically involved in mood and alcohol use disorders. OBJECTIVE: We aimed to investigate the safety of intervention with add-on bilateral prefrontal high-frequency deep transcranial magnetic stimulation (dTMS) and between-group differences in treatment response in patients with different types of depressive episodes, including major depressive episodes in the course of major depressive disorder (MDD), bipolar disorder, type I (BD-I), and MDD with alcohol use disorder (MDAUD)...
February 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29454029/sex-related-differences-in-the-association-between-grip-strength-and-depression-results-from-the-irish-longitudinal-study-on-ageing
#10
Cillian P McDowell, Brett R Gordon, Matthew P Herring
Muscular strength is a modifiable protective factor for mental health across aging populations. Evidence of sex-related differences in its associations with mental health is limited. Therefore, the purpose of this study was to examine sex-related differences in cross-sectional and prospective associations between grip strength and depressive symptoms and status. Participants were community dwelling adults (N = 4505; 56.5% female), aged ≥50 years. As a measure of muscular strength, grip strength (kg) of the dominant hand was assessed using a hand-held dynamometer at baseline...
February 14, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29453932/neurotrophin-3-restores-synaptic-plasticity-in-the-striatum-of-a-mouse-model-of-huntington-s-disease
#11
Victor G Gómez-Pineda, Francisco M Torres-Cruz, César I Vivar-Cortés, Elizabeth Hernández-Echeagaray
AIMS: Neurotrophin-3 (NT-3) is expressed in the mouse striatum; however, it is not clear the NT-3 role in striatal physiology. The expression levels of mRNAs and immune localization of the NT-3 protein and its receptor TrkC are altered in the striatum following damage induced by an in vivo treatment with 3-nitropropionic acid (3-NP), a mitochondrial toxin used to mimic the histopathological hallmarks of Huntington's disease (HD). The aim of this study was to evaluate the role of NT-3 on corticostriatal synaptic transmission and its plasticity in both the control and damaged striatum...
February 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29453926/sleep-disorder-prevalence-in-at-risk-adolescents-and-potential-effects-of-nightmare-triad-syndrome
#12
Natalia D McIver, Barry Krakow, Jessica Krakow, Michael R Nadorff, Victor A Ulibarri, Robert Baade
Objective At-risk high school students, those considered to have a higher probability for academic failure or dropping out, were assessed for various sleep disorders. Effects were compared between students with and without the nightmare triad syndrome (NTS+), the sleep disorders' cluster of frequent nightmares, insomnia disorder and suspected sleep-disordered breathing (SDB). Methods Data were gathered at a charter school for at-risk youth using: computer based surveys, physical airway exams, and mental health interviews by school social worker...
February 17, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29453804/probiotics-affect-one-carbon-metabolites-and-catecholamines-in-a-genetic-rat-model-of-depression
#13
Sandra Tillmann, Hussain M Awwad, Amanda R Eskelund, Giulia Treccani, Juergen Geisel, Gregers Wegener, Rima Obeid
SCOPE: Probiotics may influence one-carbon (C1) metabolism, neurotransmitters, liver function markers, or behavior. METHODS AND RESULTS: Male adult Flinders Sensitive Line rats (model of depression, FSL; n = 22) received Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 (10 9 or 10 10 colony-forming units/d) or vehicle for 10 weeks. The controls, Flinders Resistant Line rats (FRL, n = 8), only received vehicle. C1-related metabolites were measured in plasma, urine, and different tissues...
February 17, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29453756/acute-effects-of-unilateral-static-stretching-on-handgrip-strength-of-the-stretched-and-non-stretched-limb
#14
Jacob D Jelmini, Andrew Cornwell, Nazareth Khodiguian, Jennifer Thayer, And John Araujo
PURPOSE: To determine the effects of an acute bout of unilateral static stretching on handgrip strength of both the stretched and non-stretched limb. It was reasoned that if the non-stretched limb experienced a decrease in force output, further evidence for a neural mechanism to explain a post-stretch force reduction would be obtained as no mechanical adaptation would have occurred. METHODS: Thirty participants performed maximum voluntary unilateral handgrip contractions of both limbs before and after stretching the finger flexors of the strength-dominant side only...
February 16, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29453749/lifelong-robbery-victimisation-and-mental-disorders-at-age-18-years-brazilian-population-based-study
#15
Joseph Murray, Natália Peixoto Lima, Ana Carolina Oliveira Ruivo, Andrea Ramírez Varela, Caroline Cardozo Bortolotto, Elma Izze da Silva Magalhães, Franciéle Marabotti Costa Leite, Mariana Otero Xavier, Jean-Baptiste Pingault, Seena Fazel, Gregore Iven Mielke, Luciana Anselmi, Fernando César Wehrmeister, Helen Gonçalves, Ana Maria Baptista Menezes
PURPOSE: Urban violence is a major problem in Brazil and may contribute to mental disorders among victims. The aim of this study was to assess the association between robbery victimisation and mental health disorders in late adolescence. METHODS: At age 18 years, 4106 participants in the 1993 Pelotas Birth Cohort Study were assessed. A questionnaire about history of robbery victimisation was administered, the Self-Report Questionnaire was used to screen for common mental disorders, and the Mini International Neuropsychiatric Interview was used to assess major depressive disorder and generalised anxiety disorder...
February 17, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29453745/investigating-the-effectiveness-acceptability-and-impact-on-healthcare-usage-of-providing-a-cognitive-behavioural-based-psychological-therapy-service-for-patients-with-primary-antibody-deficiency
#16
Mari Campbell, Alex Clarke, Andrew Symes, Sarita Workman, Hans Stauss, A David Webster
PURPOSE: Patients with primary antibody deficiency report poorer quality of life and higher rates of anxiety and depression than the general population. Cognitive-behavioral therapy has been shown to be a valuable treatment for patients with other long-term physical health conditions, improving well-being and enabling them to manage their symptoms more effectively. The aim of this project was to establish the feasibility and effectiveness of providing cognitive-behavioral based therapy to patients with primary antibody deficiency...
February 17, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29453686/antipsychotic-prescribing-and-safety-monitoring-practices-in-children-and-youth-a-population-based-study-in-alberta-canada
#17
Wenxin Chen, Monica Cepoiu-Martin, Antonia Stang, Diane Duncan, Chris Symonds, Lara Cooke, Tamara Pringsheim
BACKGROUND AND OBJECTIVE: Antipsychotic medication use has steadily increased in Canada, with an expansion in the profile of users and the diagnoses for which they are used. The use of antipsychotics is associated with a number of adverse effects for which routine monitoring is recommended. The objectives of this study were to determine the most common diagnoses associated with antipsychotic use in children in Alberta, Canada and the proportion who receive recommended laboratory tests for adverse effects...
February 16, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29453604/evaluating-the-impact-of-spirituality-on-the-quality-of-life-anxiety-and-depression-among-patients-with-cancer-an-observational-transversal-study
#18
Emile Abou Chaar, Souheil Hallit, Aline Hajj, Racha Aaraj, Joseph Kattan, Hicham Jabbour, Lydia Rabbaa Khabbaz
OBJECTIVE: Spiritual well-being was found to have some protective effect against end-of life despair in cancer patients. We aimed at assessing the impact of spirituality on the quality of life, depression, and anxiety of Lebanese cancer patients. METHODS: Our observational transversal monocentric study was conducted between January and April 2016 among a convenient sample of 115 Lebanese cancer patients admitted to Hôtel-Dieu de France Hospital (HDF), Beirut-Lebanon...
February 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29453591/emotional-intelligence-empathy-and-alexithymia-in-anorexia-nervosa-during-adolescence
#19
Victoire Peres, Maurice Corcos, Marion Robin, Alexandra Pham-Scottez
PURPOSE: Socio-emotional difficulties have been observed on adult patients suffering from anorexia nervosa (AN). But researches with adolescents are scarce and non-congruent. The aim of this paper is to identify the socio-emotional difficulties that are encountered by AN during adolescence, and to isolate them from those encountered by control adolescents. METHOD: 41 AN and 38 control adolescents were assessed using the emotional quotient inventory by Bar-On, youth version (EQ-i: YV), the Toronto Alexithymia Questionnaire (TAS-20), the Interpersonal Reactivity Index (IRI), and anxiety and depression were controlled using the Hospital Anxiety and Depression Scale (HADS)...
February 16, 2018: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29453506/illness-beliefs-treatment-beliefs-and-information-needs-as-starting-points-for-patient-information-the-evaluation-of-an-intervention-for-patients-with-depression
#20
Manuela Glattacker, Katja Heyduck, Cornelia Meffert, Teresa Jakob
Patients with depression are often dissatisfied with disease- and therapy-related information. The objective of this study was to evaluate an intervention that applied the Common Sense Model to the provision of information during inpatient rehabilitation for patients with depression. The intervention was evaluated in a sequential control group design. Analyses of covariance were used to assess differences between the control and intervention groups. Changes with respect to illness and treatment beliefs (personal control, treatment control, coherence and concerns about medicines), satisfaction with information about medicines, illness and rehabilitation, and depressive burden were selected as primary outcome measures...
February 16, 2018: Journal of Clinical Psychology in Medical Settings
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