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https://www.readbyqxmd.com/read/29224183/effects-of-acute-alcohol-exposure-on-layer-5-pyramidal-neurons-of-juvenile-mice
#1
Francesco Ferrini, Benjamin Dering, Andrea De Giorgio, Laura Lossi, Alberto Granato
Early-onset drinking during childhood or preadolescence is a serious social problem. Yet, most of the basic neurobiological research on the acute effects of ethanol has been carried out on adult or early postnatal animals. We studied the effect of alcohol exposure on the basic electrophysiological properties and cell viability of layer 5 pyramidal neurons from the somatosensory cortex of juvenile (P21-P23) C57BL/6N mice. After bath application of 50 mM ethanol to acute slices of the somatosensory cortex, no adverse effects were detected on cells survival, whereas the input resistance and firing rate of layer 5 neurons were significantly reduced...
December 9, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29224058/systematic-assessment-and-characterization-of-chronic-pain-in-multiple-sclerosis-patients
#2
Diana Ferraro, Domenico Plantone, Franca Morselli, Giulia Dallari, Anna M Simone, Francesca Vitetta, Patrizia Sola, Guido Primiano, Viviana Nociti, Matteo Pardini, Massimiliano Mirabella, Catello Vollono
Pain is one of the most disabling clinical symptoms in patients with multiple sclerosis (MS). Several studies have already assessed the prevalence of pain in MS patients, reporting variable results, probably due to methodological differences. The aim of this single-centre cross-sectional study was to define the prevalence and characteristics of chronic pain in a population of MS patients using validated tools, and to analyse these data in relation to demographic and clinical features, including disease duration and disability (EDSS and its single functional system scores)...
December 9, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29224023/negative-symptoms-and-avoidance-of-social-interaction-a-study-of-non-verbal-behaviour
#3
Elizabeth Worswick, Sara Dimic, Christiane Wildgrube, Stefan Priebe
BACKGROUND: Non-verbal behaviour is fundamental to social interaction. Patients with schizophrenia display an expressivity deficit of non-verbal behaviour, exhibiting behaviour that differs from both healthy subjects and patients with different psychiatric diagnoses. The present study aimed to explore the association between non-verbal behaviour and symptom domains, overcoming methodological shortcomings of previous studies. SAMPLING AND METHODS: Standardised interviews with 63 outpatients diagnosed with schizophrenia were videotaped...
December 9, 2017: Psychopathology
https://www.readbyqxmd.com/read/29224000/the-depression-anxiety-and-stress-scale-dass-21-as-a-screener-for-depression-in-substance-use-disorder-inpatients-a-pilot-study
#4
Ilse N Beaufort, Gerdien H De Weert-Van Oene, Victor A J Buwalda, J Rob J de Leeuw, Anna E Goudriaan
Depression is a common co-morbid disorder in substance use disorder (SUD) patients. Hence, valid instruments are needed to screen for depression in this subpopulation. In this study, the predictive validity of the Depression, Anxiety and Stress Scale (DASS-21) for the presence of a depressive disorder was investigated in SUD inpatients. Furthermore, differences between DASS-21 scores at intake and those recorded one week after inpatient detoxification were assessed in order to determine the measurement point of the assessment of the DASS-21 leading to the best predictive validity...
December 8, 2017: European Addiction Research
https://www.readbyqxmd.com/read/29223913/prevalence-of-childhood-trauma-and-correlations-between-childhood-trauma-suicidal-ideation-and-social-support-in-patients-with-depression-bipolar-disorder-and-schizophrenia-in-southern-china
#5
Peng Xie, Kai Wu, Yingjun Zheng, Yangbo Guo, Yuling Yang, Jianfei He, Yi Ding, Hongjun Peng
BACKGROUND: Childhood trauma has long-term adverse effects on physical and psychological health. Previous studies demonstrated that suicide and mental disorders were related to childhood trauma. In China, there is insufficient research available on childhood trauma in patients with mental disorders. METHODS: Outpatients were recruited from a psychiatric hospital in southern China, and controls were recruited from local communities. The demographic questionnaire, the Childhood Trauma Questionnaire-Short Form (CTQ-SF), and the Social Support Rating Scale (SSRS) were completed by all participants, and the Self-rating Idea of Suicide Scale (SIOSS) were completed only by patients...
November 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29223873/molecular-characterization-and-expression-profiles-of-lpxrfa-at-the-brain-pituitary-gonad-axis-of-half-smooth-tongue-sole-cynoglossus-semilaevis-during-ovarian-maturation
#6
Bin Wang, Quan Liu, Xuezhou Liu, Yongjiang Xu, Bao Shi
Gonadotropin-inhibitory hormone (GnIH) has been characterized by its ability to inhibit either basal or gonadotropin-releasing hormone (GnRH)-induced gonadotropin synthesis and release in birds and mammals. However, the physiological role of GnIH on the reproductive axis in fish remains inconclusive, with most studies focusing on the orders Cypriniformes and Perciformes. To gain insight into the role of GnIH in the regulation of reproduction in the order Pleuronectiformes, we first cloned the LPXRFa gene, the piscine ortholog of GnIH, in the half-smooth tongue sole...
December 6, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29223792/prediction-of-persistent-hemodynamic-depression-after-carotid-angioplasty-and-stenting-using-artificial-neural-network-model
#7
Jin Pyeong Jeon, Chulho Kim, Byoung-Doo Oh, Sun Jeong Kim, Yu-Seop Kim
OBJECTIVES: To assess and compare predictive factors for persistent hemodynamic depression (PHD) after carotid artery angioplasty and stenting (CAS) using artificial neural network (ANN) and multiple logistic regression (MLR) or support vector machines (SVM) models. PATIENTS AND METHODS: A retrospective data set of patients (n=76) who underwent CAS from 2007 to 2014 was used as input (training cohort) to a back-propagation ANN using TensorFlow platform. PHD was defined when systolic blood pressure was less than 90mmHg or heart rate was less 50 beats/min that lasted for more than one hour...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29223774/physiological-and-proteomic-responses-to-corticosteroid-treatments-in-eurasian-perch-perca-fluviatilis-investigation-of-immune-related-parameters
#8
Sylvain Milla, Sophie Massart, Cédric Mathieu, Neil Wang, Caroline Douny, Jessica Douxfils, Marie-Louise Scippo, Edwin De Pauw, Marc Dieu, Frédéric Silvestre, Patrick Kestemont
The comparative effects of cortisol and 11-deoxycorticosterone (DOC), two major corticosteroids in fish, have yet received little attention in teleosts. We evaluated the proteomic and immune responses of Eurasian perch to chronic corticosteroid treatments. We implanted immature perch with cortisol (80mg/kg) or DOC (4mg/kg) and measured the proportions of blood leucocytes, immune indices in the plasma, spleen and liver (complement and lysozyme activity, total immunoglobulin and immune gene expression in the tissues) and differential proteome expression (corticosteroid versus control) in the liver and the spleen on days 2, 4 and 14 post-treatment...
December 1, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/29223603/factors-predicting-quality-of-life-and-societal-participation-after-survival-of-a-cardiac-arrest-a-prognostic-longitudinal-cohort-study
#9
Daan Verberne, Veronique Moulaert, Jeanine Verbunt, Caroline van Heugten
AIM: For those patients who suffer unfavourable outcome after survival of cardiac arrest, it is important to know whether this can be predicted at an early stage. Support can subsequently be provided. This study aimed to identify early prognostic factors of quality of life (QOL) and societal participation at one year post-cardiac arrest. METHODS: The design was a prospective longitudinal cohort study following cardiac arrest survivors up to one year. Prognostic personal, injury-related, function-related and subjective outcome factors were selected and entered into a hierarchical regression model to assess whether they were predictive of QOL and societal participation at one year post-cardiac arrest...
December 6, 2017: Resuscitation
https://www.readbyqxmd.com/read/29223579/design-considerations-for-handling-dropouts-in-anti-depressant-drug-trials
#10
Jinglin Zhong, Ni A Khin, Peiling Yang
BACKGROUND: In clinical trials, statistical analysis often requires certain assumptions about missing data for a valid statistical inference. If the dropout rate is high, a wrong assumption about the missing data may compromise the validity of statistical inferences. PURPOSE: To mitigate the high dropout rates commonly observed in psychiatry clinical trials, we consider two design approaches for short-term controlled trials submitted in support of marketing applications for drug products for the major depressive disorder (MDD) indication: (1) shortening the trial duration and (2) treating time to treatment discontinuation as an alternative primary efficacy endpoint...
December 6, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29223529/corticosterone-impairs-gap-junctions-in-the-prefrontal-cortical-and-hippocampal-astrocytes-via-different-mechanisms
#11
Cong-Yuan Xia, Zhen-Zhen Wang, Zhao Zhang, Jiao Chen, Ying-Ying Wang, Yu-Xia Lou, Yan Gao, Piao Luo, Qian Ren, Guo-Hua Du, Nai-Hong Chen
Increasing evidence has implicated astrocyte pathology in the etiopathology of major depressive disorder (MDD). In particular, dysfunction of gap junctions in astrocytes is a potential target for MDD treatment. However, the mechanism underlying stress-induced dysfunction of gap junctions is still unknown. We therefore studied the mechanism of stress-induced dysfunction of gap junctions in prefrontal cortical and hippocampal astrocytes. Corticosterone (CORT) was used to induce stress conditions; CORT damaged the function of gap junctions, which resulted from less distribution of connexin43 (Cx43) on membranes and the enhanced phosphorylation of Cx43 at S368...
December 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29223522/custom-made-titanium-3d-printed-interbody-cages-for-treatment-of-osteoporotic-fracture-related-spinal-deformity
#12
Timothy Siu, Jeffrey M Rogers, Kainu Lin, Robert Thompson, Mark Owbridge
BACKGROUND: Advances in minimally invasive interbody fusion have greatly enhanced surgeons' capability to correct adult spinal deformity with reduced morbidity. However, the feasibility of such approaches is limited in patients with previous osteoporotic fractures as the resultant vertebral deformity renders the endplate geometry incongruous with conventional interbody implants. Current 3D printing technology offers a novel solution by fabricating custom-made implants tailored to individual anatomy...
December 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29223281/human-studies-on-hypothalamo-pituitary-adrenal-hpa-axis
#13
REVIEW
Kamani Liyanarachchi, Richard Ross, Miguel Debono
The daily rhythm of the hypothalamo-pituitary-adrenal (HPA) axis is regulated by the central clock in the suprachiasmatic nucleus. Cortisol, a glucocorticoid, acts as a secondary messenger between the central clock and the peripheral tissues. Changes in clock time, as seen in shift workers, alters the HPA axis and results in metabolic disturbances associated with ill health. Depression, anorexia nervosa and obstructive sleep apnoea, are associated with cortisol rhythm phase shifts and increased cortisol exposure...
October 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29223209/nurse-led-initiatives-to-implement-universal-screening-for-perinatal-emotional-complications
#14
Marissa Tenenbaum Potter
Perinatal emotional complications are the most common pregnancy complications in the United States. This article reviews three recent studies that illustrate the prevalence of and risk factors for perinatal emotional complications and sheds light on the inconsistency of screening by health care providers in acute care and outpatient settings. Also presented is an example of nurse-led quality improvement initiatives aimed at implementing universal screening in a rural New England county, which resulted in 100% screening with the Edinburgh Postnatal Depression Scale across health care facilities within the community, as well as a system-wide change in the approach to identifying and treating perinatal emotional complications...
December 2017: Nursing for Women's Health
https://www.readbyqxmd.com/read/29223191/iterating-a-framework-for-the-prevention-of-caregiver-depression-in-dementia-a-multi-method-approach
#15
Jiangbo Ying, Philip Yap, Mihir Gandhi, Tau Ming Liew
BACKGROUND: Dementia caregiving is often stressful and depression in family caregivers is not uncommon. As caregiver depression can have significant effects, there is a need for preventive efforts which are consistent with the extensive literature. We sought to consolidate the wide range of evidence (using a multi-method approach) into a simple framework that can guide the prevention of caregiver depression. METHODS: Using multiple logistic regression, we derived the predictors of caregiver depression from an empirical dataset containing key information and depression scores (based on the Center-for-Epidemiological-Studies-Depression-Scale) of 394 family caregivers...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29223188/disordered-eating-in-sami-and-non-sami-norwegian-populations-the-saminor-2-clinical-survey
#16
Kirsti Kvaløy, Marita Melhus, Anne Silviken, Magritt Brustad, Tore Sørlie, Ann Ragnhild Broderstad
OBJECTIVE: The present study aimed to investigate disordered eating (DE) among Sami compared with non-Sami residing in northern Norway. DESIGN: In a cross-sectional design, stratified by sex and ethnicity, associations were tested between DE (Eating Disturbance Scale; EDS-5) and age, education level, BMI category, anxiety and depression, physical activity and consumption of snacks. SETTING: The SAMINOR 2 Clinical Survey (2012-2014) based on the population of ten municipalities in northern Norway...
December 10, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29223177/well-being-and-distress-of-patients-with-parkinson-s-disease-a-comparative-investigation
#17
Francesca Vescovelli, Daniele Sarti, Chiara Ruini
BACKGROUND: Psychological resources, such as psychological well-being (PWB) and life satisfaction (LS) can aid individuals suffering from chronic illnesses to cope with their illness. The aim of this study was to investigate PWB, LS, quality of life (QoL), and distress in patients with Parkinson's disease (PD) and to compare them with healthy controls. METHODS: One hundred and thirteen individuals were recruited. Fifty of the participants suffered from PD, while 53 individuals reported other non-neurological diseases...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29223176/the-influence-of-exposure-to-natural-disasters-on-depression-and-ptsd-symptoms-among-firefighters
#18
Michelle L Pennington, Thomas P Carpenter, Samantha J Synett, Victoria A Torres, Jennifer Teague, Sandra B Morissette, Jeffrey Knight, Barbara W Kamholz, Terence M Keane, Rose T Zimering, Suzy B Gulliver
Introduction Firefighters represent an important population for understanding the consequences of exposure to potentially traumatic stressors. Hypothesis/Problem The researchers were interested in the effects of pre-employment disaster exposure on firefighter recruits' depression and posttraumatic stress disorder (PTSD) symptoms during the first three years of fire service and hypothesized that: (1) disaster-exposed firefighters would have greater depression and PTSD symptoms than non-exposed overall; and (2) depression and PTSD symptoms would worsen over years in fire service in exposed firefighters, but not in their unexposed counterparts...
December 10, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29223174/relationships-between-the-neighborhood-environment-and-depression-in-older-adults-a-systematic-review-and-meta-analysis
#19
Anthony Barnett, Casper J P Zhang, Janice M Johnston, Ester Cerin
BACKGROUND: While depression is a growing public health issue, the percentage of individuals with depression receiving treatment is low. Physical and social attributes of the neighborhood may influence the level of depressive symptoms and the prevalence of depression in older adults. METHODS: This review systematically examined the literature on neighborhood environmental correlates of depression in older adults. Findings were analyzed according to three depression outcomes: depressive symptoms, possible depression, and clinical depression...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29223173/the-worried-well-characteristics-of-cognitively-normal-patients-presenting-to-a-rural-and-remote-memory-clinic
#20
Ryan Verity, Andrew Kirk, Megan E O'Connell, Chandima Karunanayake, Debra G Morgan
INTRODUCTION: In an effort to better understand why cognitively normal patients were referred to a memory clinic, we sought to identify features of "worried well" patients to better identify those more likely to be cognitively normal. METHODS: In total, 375 consecutive patients referred by primary care practitioners to a Rural and Remote Memory Clinic were categorized into two groups based on their neurologic diagnosis, "worried well" (cognitively normal, N=81) or "other" (patients with any neurologic diagnosis, N=294)...
December 10, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
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