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https://www.readbyqxmd.com/read/28550300/experimental-quantum-chemical-and-molecular-dynamic-simulations-studies-on-the-corrosion-inhibition-of-mild-steel-by-some-carbazole-derivatives
#1
Henry U Nwankwo, Lukman O Olasunkanmi, Eno E Ebenso
Five selected carbazole derivatives, namely carbazole, 3,6-dibromocarbazole, 2-hydroxycarbazole, 1,2,3,4-tetrahydrocarbazole and 9-(2-ethylhexyl)carbazole-3,6-dicarboxaldehyde were investigated for their inhibitive effects on Desulfovibrio vulgaris (D. vulgaris) induced corrosion of mild steel and in 1 M HCl medium using weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques. The carbazole derivatives were found to be mixed type inhibitors with predominantly cathodic inhibitive effects for mild steel in 1 M HCl...
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28550144/exacerbation-of-oxygen-glucose-deprivation-induced-blood-brain-barrier-disruption-potential-pathogenic-role-of-interleukin-9-in-ischemic-stroke
#2
Sha Tan, Yilong Shan, Yuge Wang, Yinyao Lin, Siyuan Liao, Zhezhi Deng, Li Zhou, Wei Cai, Qin Zeng, Lei Zhang, Bingjun Zhang, Xuejiao Men, Haiyan Li, Xueqiang Hu, Changyou Wu, Lisheng Peng, Zhengqi Lu
Interleukin (IL) -9 exerts a variety of functions in autoimmune diseases. However, its role in ischemic brain injury remains unknown. The present study explored the biological effects of IL-9 in ischemic stroke. We recruited 42 patients newly diagnosed with ischemic stroke and 22 age- and sex-matched healthy controls. The expression levels of IL-9 and percentages of IL-9-producing T cells, including CD3+CD4+IL-9+ and CD3+CD8+IL-9+ cells, were determined in peripheral blood mononuclear cells (PBMCs) obtained from patients and control individuals...
May 26, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28548478/influencing-of-antioxidants-gene-variants-on-risk-of-diabetes-mellitus-and-its-complications-a-systematic-review
#3
Fatemeh Bitarafan, Mehrnoosh Khodaeian, Ozra Tabatabaei-Malazy, Mahsa M Amoli
INTRODUCTION: Oxidative stress has a key role in pathophysiology of type 2 diabetes mellitus (T2DM) and its complications as a most common health problem. Due to controversial evidence regarding the association between antioxidants' gene varients and T2DM, our aim was a systematic review of the current meta-analyses. EVIDENCE ACQUISTION: All meta-analysis' studies which assessed the association of single nucleotide polymorphisms of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPX), glutathione S transferase (GST), nitric oxide synthase (NOS) and nicotinamide adenine dinucleotide phosphate oxidase (NOX) with T2DM and its complications were systematically extracted from PubMed, Scopus and Web of Science databases up to January 2016...
May 26, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28546854/sirt1-inhibits-oxidative-stress-in-vascular-endothelial-cells
#4
REVIEW
Weijin Zhang, Qiaobing Huang, Zhenhua Zeng, Jie Wu, Yaoyuan Zhang, Zhongqing Chen
The vascular endothelium is a layer of cells lining the inner surface of vessels, serving as a barrier that mediates microenvironment homeostasis. Deterioration of either the structure or function of endothelial cells (ECs) results in a variety of cardiovascular diseases. Previous studies have shown that reactive oxygen species (ROS) is a key factor that contributes to the impairment of ECs and the subsequent endothelial dysfunction. The longevity regulator Sirt1 is a NAD(+)-dependent deacetylase that has a potential antioxidative stress activity in vascular ECs...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28544111/kallistatin-reduces-vascular-senescence-and-aging-by-regulating-microrna-34a-sirt1-pathway
#5
Youming Guo, Pengfei Li, Lin Gao, Jingmei Zhang, Zhirong Yang, Grant Bledsoe, Eugene Chang, Lee Chao, Julie Chao
Kallistatin, an endogenous protein, protects against vascular injury by inhibiting oxidative stress and inflammation in hypertensive rats and enhancing the mobility and function of endothelial progenitor cells (EPCs). We aimed to determine the role and mechanism of kallistatin in vascular senescence and aging using cultured EPCs, streptozotocin (STZ)-induced diabetic mice, and Caenorhabditis elegans (C. elegans). Human kallistatin significantly decreased TNF-α-induced cellular senescence in EPCs, as indicated by reduced senescence-associated β-galactosidase activity and plasminogen activator inhibitor-1 expression, and elevated telomerase activity...
May 24, 2017: Aging Cell
https://www.readbyqxmd.com/read/28542422/angelica-dahurica-ethanolic-extract-improves-impaired-wound-healing-by-activating-angiogenesis-in-diabetes
#6
Xiao-Na Zhang, Ze-Jun Ma, Ying Wang, Bei Sun, Xin Guo, Cong-Qing Pan, Li-Ming Chen
Abnormal angiogenesis plays an important role in impaired wound healing and development of chronic wounds in diabetes mellitus. Angelica dahurica radix is a common traditional Chinese medicine with wide spectrum medicinal effects. In this study, we analyzed the potential roles of Angelica dahurica ethanolic extract (ADEE) in correcting impaired angiogenesis and delayed wound healing in diabetes by using streptozotocin-induced diabetic rats. ADEE treatment accelerated diabetic wound healing through inducing angiogenesis and granulation tissue formation...
2017: PloS One
https://www.readbyqxmd.com/read/28540569/altered-purinergic-signaling-in-uridine-adenosine-tetraphosphate-induced-coronary-relaxation-in-swine-with-metabolic-derangement
#7
Zhichao Zhou, Oana Sorop, Vincent J de Beer, Ilkka Heinonen, Caroline Cheng, A H Jan Danser, Dirk J Duncker, Daphne Merkus
We previously demonstrated that uridine adenosine tetraphosphate (Up4A) induces potent and partially endothelium-dependent relaxation in the healthy porcine coronary microvasculature. We subsequently showed that Up4A-induced porcine coronary relaxation was impaired via downregulation of P1 receptors after myocardial infarction. In view of the deleterious effect of metabolic derangement on vascular function, we hypothesized that the coronary vasodilator response to Up4A is impaired in metabolic derangement, and that the involvement of purinergic receptor subtypes and endothelium-derived vasoactive factors (EDVFs) is altered...
May 24, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28539820/bifidobacterium-pseudocatenulatum-cect-7765-supplementation-restores-altered-vascular-function-in-an-experimental-model-of-obese-mice
#8
María D Mauricio, Eva Serna, María Leonor Fernández-Murga, Jesica Portero, Martín Aldasoro, Soraya L Valles, Yolanda Sanz, José M Vila
Aims.Bifidobacterium pseudocatenulatum CECT 7765 improves metabolic and immunological altered functions in high fat fed mice, however little is known about the effects of potential probiotics on vascular reactivity. The aim of the present study was to investigate the effects of a potential probiotic strain, Bifidobacterium pseudocatenulatum CECT 7765, on vascular response in obese mice. Methods. Aorta samples were obtained from mice, which were divided into three groups: a control group, receiving a standard diet; an obese group, receiving a high-fat diet; and an obese group receiving high-fat diet and a daily dose of B...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28539257/propranolol-treatment-lowers-blood-pressure-reduces-vascular-inflammatory-markers-and-improves-endothelial-function-in-obese-mice
#9
Nathalia da Silva Franco, Camila Lubaczeuski, Daniele M Guizoni, Jamaira A Victorio, Junia C Santos-Silva, Patricia C Brum, Everardo M Carneiro, Ana P Davel
Obesity-associated hypertension is accompanied by a number of cardiovascular risk factors including vascular insulin resistance (IR) and higher sympathetic nervous activity. Therefore, autonomic blockade was demonstrated to reverse hypertension, endothelial dysfunction and IR in obese individuals. We hypothesized that β-AR blockade with propranolol would restore endothelial function and vascular insulin signaling in obesity, associated with an anti-inflammatory effect. Body weight, systolic blood pressure (SBP), plasma biochemical parameters and aortic endothelial function were analyzed in mice fed standard diet (control group) or a high fat diet (HFD) that were treated with vehicle (water) or propranolol (10mg/kg/day) for 8 weeks...
May 21, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28538813/mechanisms-of-endothelial-protection-by-natural-bioactive-compounds-from-fruit-and-vegetables
#10
Bernardita Monsalve, Anibal Concha-Meyer, Iván Palomo, Eduardo Fuentes
The endothelium is fundamental for the regulation of vascular tone and structure. Under disease conditions, including the presence of cardiovascular disease risk factors, the endothelium loses its protective role and becomes a proatherosclerotic structure. In this article we searched for strategies from PUBMED and Science Direct databases using the following key words: endothelium, natural bioactive compounds, polyphenols and cardiovascular diseases. The search was restricted to english language papers. Studies have identified the contribution of diet to the risk of developing cardiovascular diseases...
May 22, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28538666/melatonin-attenuates-pulmonary-hypertension-in-chronically-hypoxic-rats
#11
Ming Wai Hung, Hang Mee Yeung, Chi Fai Lau, Angela Ming See Poon, George L Tipoe, Man Lung Fung
Chronic hypoxia induces pulmonary hypertension and vascular remodeling, which are clinically relevant to patients with chronic obstructive pulmonary disease (COPD) associated with a decreased level of nitric oxide (NO). Oxidative stress and inflammation play important roles in the pathophysiological processes in COPD. We examined the hypothesis that daily administration of melatonin (10 mg/kg) mitigates the pulmonary hypertension and vascular remodeling in chronically hypoxic rats. The right ventricular systolic pressure (RVSP) and the thickness of pulmonary arteriolar wall were measured from normoxic control, vehicle- and melatonin-treated hypoxic rats exposed to 10% O₂ for 14 days...
May 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28537115/wiederkehrende-abdominelle-schmerzen-%C3%A3-belkeit-und-heisses-baden-%C3%A2-eine-neue-trias
#12
Oscar Ormachea, Enos Bernasconi, Marco Pons, Tanja Fusi-Schmidhauser
No abstract text is available yet for this article.
2017: Praxis
https://www.readbyqxmd.com/read/28534941/two-natural-eudesmane-type-sesquiterpenes-from-laggera-alata-inhibit-angiogenesis-and-suppress-breast-cancer-cell-migration-through-vegf-and-angiopoietin-2-mediated-signaling-pathways
#13
Ning Liang, Yaolan Li, Hau Yin Chung
Eudesmane-type sesquiterpenes are natural sesquiterpenes with anti-inflammatory properties, but their anti-angiogenic activities are not known. The present study demonstrated that 5α-hydroxycostic acid and hydroxyisocostic acid, two eudesmane-type sesquiterpenes (ETSs), isolated from the herb Laggera alata, possessed anti-angiogenic effects. Under non-toxic dosage, ETSs suppressed VEGF‑induced proliferation in human umbilical vein endothelial cells (HUVECs) and vessel formation in zebrafish embryos. Moreover, ETSs inhibited VEGF-stimulated HUVEC migration, stress fibers and tube formation...
May 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28533289/treatment-with-standard-and-low-dose-of-conjugated-equine-estrogen-differentially-modulates-estrogen-receptor-expression-and-response-to-angiotensin-ii-in-mesenteric-venular-bed-of-surgically-postmenopausal-hypertensive-rats
#14
Priscila Xavier Araujo, Tiago Januario Costa, Cinthya Echem, Maria Aparecida Oliveira, Rosangela Aparecida Santos-Eichler, Lucas Giglio Colli, Francesc Jimenez-Altayo, Elisabet Vila, Eliana Hiromi Akamine, Ana Paula Dantas, Graziela Scalianti Ceravolo, Maria Helena Catelli de Carvalho
Standard hormone therapy for menopausal women [conjugated equine estrogen (CEE) 0.625 mg] has been associated with increased risk of venous thrombosis. Regimens containing lower CEE dose (0.30 mg) have been clinically used to decrease side effects of supra-physiological doses of estrogen. In this study, we determined the effects of standard (SD) and low (LD) dose of CEE on venular function in ovariectomized (OVX) spontaneously hypertensive rats (SHR). Contractions to Angiotensin-II (Ang-II 10μM) in perfused mesenteric venular bed were markedly increased in OVX (21...
May 22, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28532842/effects-of-diet-and-arginine-treatment-during-the-luteal-phase-on-ovarian-no-pgc-1%C3%AE-signaling-in-ewes
#15
Yi-Xuan Guo, Hai-Tao Nie, Ling-Wei Sun, Guo-Min Zhang, Kai-Ping Deng, Yi-Xuan Fan, Feng Wang
The aim of this study was to determine whether arginine (Arg) supplementation of malnourished ewes affects the expression of key NO/PGC-1α signaling pathway genes in the ovary. On Day 6-15 of the estrous cycle, 24 multiparous Hu sheep (BW = 43.56 ± 1.53 kg) were randomly assigned to three groups: control group (CG; n = 6), restriction group (RG; n = 9) and l-arginine group (AG; n = 9), and administered Arg treatment (or vehicle) three times per day. The ewes were slaughtered at the end of treatment, and blood samples and ovaries were collected for analysis...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28529128/role-of-gper-in-the-activation-of-endothelial-nitric-oxide-synthase
#16
Natalie C Fredette, Matthias R Meyer, Eric R Prossnitz
Estrogens are potent regulators of vascular tone, yet underlying receptor- and ligand-specific signaling pathways remain poorly characterized. The primary physiological estrogen 17β-estradiol (E2), a non-selective agonist of classical nuclear estrogen receptors (ERα and ERβ) as well as the G protein-coupled estrogen receptor (GPER), stimulates formation of the vasodilator nitric oxide (NO) in endothelial cells. Here, we studied the contribution of GPER signaling in E2-dependent activation of endothelial NO formation and subsequent vasodilation...
May 18, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28529061/benzo-a-pyrene-7-8-diol-9-10-epoxide-suppresses-the-migration-and-invasion-of-human-extravillous-trophoblast-htr-8-svneo-cells-by-down-regulating-mmp2-through-inhibition-of-fak-src-pi3k-akt-pathway
#17
Rong Wang, Weiping Wang, Lin Ao, Zhi Wang, Xianglin Hao, Huidong Zhang
Moderate invasion of trophoblasts into the endometrium is crucial for successful pregnancy. Benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) is a carcinogenic metabolite of benzo[a]pyrene which causes various diseases. We investigated the effects of BPDE on migration and invasion of trophoblast HTR-8/SVneo cells. Migration and invasion of cells exposed to 0.25-1.0μM BPDE for 24h were significantly inhibited. Moreover, tube formation of human umbilical vein endothelial cell (HUVEC) was also significantly reduced after incubation with HTR-8/SVneo cells treated with 0...
May 18, 2017: Toxicology
https://www.readbyqxmd.com/read/28528862/crocetin-restores-diabetic-endothelial-progenitor-cell-dysfunction-by-enhancing-no-bioavailability-via-regulation-of-pi3k-akt-enos-and-ros-pathways
#18
Wei Cao, Jinjin Cui, Shufeng Li, Donghui Zhang, Yibo Guo, Qiannan Li, Ying Luan, Xian Liu
AIMS: Endothelial progenitor cell (EPC) dysfunction underlies a critical risk factor in diabetic vascular complications due to function defect in restoring endothelium injury. Crocetin has attracted increasing attention in several vascular-related diseases. In present study, we aimed to explore the role of crocetin in diabetic EPC dysfunction. MAIN METHODS: EPCs were isolated from bone marrow in diabetic mice and identified using the fluorescence staining and flow cytometry...
May 18, 2017: Life Sciences
https://www.readbyqxmd.com/read/28527876/short-term-exposure-of-erythropoietin-impairs-endothelial-function-through-inhibition-of-nitric-oxide-production-and-enos-mrna-expression-in-the-rat-pulmonary-artery
#19
Faheem Sultan, Thakur Uttam Singh, Tarun Kumar, Soya Rungsung, Dipankar Jyoti Rabha, Anamika Vishwakarma, Susanth V Sukumaran, Arunvikram Kandasamy, Subhashree Parida
BACKGROUND: Administration of recombinant erythropoietin (rEPO) is often associated with systemic and pulmonary arterial hypertension in animals and human. The present study was conducted to determine whether one-week rEPO-treatment can produce any effect on pulmonary vasomotor function. METHODS: Male Wistar rats were injected with rEPO (400IU/kg sc) or saline every other day for one week. Tension, biochemical and Real-Time PCR experiments were conducted on left and right branches of pulmonary artery and main pulmonary artery isolated from the rats...
February 4, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28526707/s-nitrosylation-of-vasp-at-cysteine-64-mediates-inflammation-stimulated-increase-in-microvascular-permeability
#20
Patricia Zamorano, Natalie Marin, Francisco Córdova, Alejandra Aguilar, Cynthia J Meininger, Mauricio P Boric, Nikola Golenhofen, Jorge Contreras, José Sarmiento, Walter N Duran, Fabiola A Sánchez
We tested the hypothesis that platelet-activating factor (PAF) induces S-nitrosylation of vasodilator-stimulated phosphoprotein (VASP) as a mechanism to reduce microvascular endothelial barrier integrity and stimulate hyperpermeability. PAF elevated S-nitrosylation of VASP above baseline levels in different endothelial cells and caused hyperpermeability. To ascertain the importance of eNOS subcellular location in this process, we used ECV-304 cells transfected with cytosolic eNOS (GFPeNOSG2A) and plasma membrane eNOS (GFPeNOSCAAX)...
May 19, 2017: American Journal of Physiology. Heart and Circulatory Physiology
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