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https://read.qxmd.com/read/38562302/editorial-data-driven-clinical-biosignatures-and-treatment-for-neurodegenerative-diseases-volume-ii
#21
EDITORIAL
Nizhuan Wang, Lei Chen, Wei Kong, Chung Y Hsu, I-Shiang Tzeng
No abstract text is available yet for this article.
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38556574/microglial-phagolysosome-dysfunction-and-altered-neural-communication-amplify-phenotypic-severity-in-prader-willi-syndrome-with-larger-deletion
#22
JOURNAL ARTICLE
Felipe Correa-da-Silva, Jenny Carter, Xin-Yuan Wang, Rui Sun, Ekta Pathak, José Manuel Monroy Kuhn, Sonja C Schriever, Clarissa M Maya-Monteiro, Han Jiao, Martin J Kalsbeek, Pedro M M Moraes-Vieira, Johan J P Gille, Margje Sinnema, Constance T R M Stumpel, Leopold M G Curfs, Dirk Jan Stenvers, Paul T Pfluger, Dominik Lutter, Alberto M Pereira, Andries Kalsbeek, Eric Fliers, Dick F Swaab, Lawrence Wilkinson, Yuanqing Gao, Chun-Xia Yi
Prader-Willi Syndrome (PWS) is a rare neurodevelopmental disorder of genetic etiology, characterized by paternal deletion of genes located at chromosome 15 in 70% of cases. Two distinct genetic subtypes of PWS deletions are characterized, where type I (PWS T1) carries four extra haploinsufficient genes compared to type II (PWS T2). PWS T1 individuals display more pronounced physiological and cognitive abnormalities than PWS T2, yet the exact neuropathological mechanisms behind these differences remain unclear...
March 31, 2024: Acta Neuropathologica
https://read.qxmd.com/read/38555791/impaired-glymphatic-clearance-in-multiple-system-atrophy-a-diffusion-spectrum-imaging-study
#23
JOURNAL ARTICLE
Chuanying Shi, Guifang Guo, Weifei Wang, Haiyan Yu, Hua Fan, Peng Wu, Peiji Song, Dianrong Gong
INTRODUCTION: Impaired α-synuclein clearance is pivotal in the pathogenesis of neurodegenerative diseases. We evaluated glymphatic clearance in multiple system atrophy (MSA) patients using advanced imaging. METHODS: Forty-four MSA patients (11 with MSA-parkinsonian type [MSA-P] and 33 with MSA-cerebellar type [MSA-C]) and 30 healthy controls were studied using diffusion spectrum magnetic resonance imaging (DSI-MRI). Diffusivities were measured along the x-, y-, and z-axes to calculate the Analysis Along the Perivascular Space (ALPS) index...
March 29, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38553903/cannabidiol-alleviates-neurological-deficits-after-traumatic-brain-injury-by-improving-intracranial-lymphatic-drainage
#24
JOURNAL ARTICLE
Shiying Dong, Hongwei Zhao, Meng Nie, Zhuang Sha, Jiancheng Feng, Mingqi Liu, Chuanxiang Lv, Yupeng Chen, Weiwei Jiang, Jiangyuan Yuan, Yu Qian, Honggang Wan, Chuang Gao, Rongcai Jiang
Traumatic brain injury (TBI)-a severe clinical problem-is compounded by a lack of effective treatments and impeded intracranial metabolic waste clearance. The glymphatic system and meningeal lymphatic vessels are instrumental in TBI pathophysiology and crucial for clearing harmful substances. Cannabidiol (CBD) has the potential to address metabolic imbalances and improve cognitive functions in neurodegenerative diseases, but its specific effect on TBI remains unclear. Using a fluid percussion injury model, we adopted a comprehensive approach that included behavioral testing, various imaging techniques, and deep cervical lymph node (dCLN) ligation to evaluate CBD's effects on neurological outcomes and lymphatic clearance in a TBI mouse model...
March 30, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38545038/association-between-body-mass-index-and-glymphatic-function-using-diffusion-tensor-image-along-the-perivascular-space-dti-alps-in-patients-with-parkinson-s-disease
#25
JOURNAL ARTICLE
Shijiao Tian, Hui Hong, Xiao Luo, Qingze Zeng, Peiyu Huang, Minming Zhang
BACKGROUND: Obesity is considered a risk factor for the development of several neurodegenerative diseases, including Parkinson's disease (PD). Recent studies have revealed that glymphatic function is compromised in PD patients. This study aims to investigate the impact of different body mass index (BMI) statuses on glymphatic system function in PD patients using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method. METHODS: This study used a cross-sectional study design...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38533966/spaceflight-associated-neuro-ocular-syndrome-potential-etiologies-and-connections-to-the-glymphatic-system
#26
REVIEW
Joshua M Venegas
The etiology of spaceflight-associated neuro-ocular syndrome (SANS) is a developing field of research, with many current hypotheses receiving varying degrees of support. In this article, three prominent risk factors including zero gravity conditions, extraterrestrial hypercapnic environments, and individual genetic predisposition are described and their pathophysiological pathways are compared. In addition, glymphatic system impairment is explored as a potential mutual endpoint for these pathways in the development of SANS...
March 27, 2024: Journal of Neurophysiology
https://read.qxmd.com/read/38533660/glymphatic-system-impairment-contributes-to-the-formation-of-brain-edema-after-ischemic-stroke
#27
JOURNAL ARTICLE
Juan Zhu, Jiaying Mo, Kewei Liu, Quanfeng Chen, Zheqi Li, Yihua He, Yuan Chang, Chuman Lin, Mingjia Yu, Yikai Xu, Xiangliang Tan, Kaibin Huang, Suyue Pan
BACKGROUND: Blood-brain barrier damage has traditionally been considered to determine the occurrence and development of poststroke brain edema, a devastating and life-threatening complication. However, no treatment strategy targeting blood-brain barrier damage has been proven clinically effective in ameliorating brain edema. METHODS: In mice with stroke models induced by transient middle cerebral artery occlusion (MCAO), the changes in glymphatic system (GS) function impairment were detected by ex vivo fluorescence imaging, 2-photon in vivo imaging, and magnetic resonance imaging within 1 week after MCAO, and the effects of GS impairment and recovery on the formation and resolution of brain edema were evaluated...
March 27, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38532513/role-of-aquaporin-4-polarization-in-extracellular-solute-clearance
#28
JOURNAL ARTICLE
Laura Bojarskaite, Sahar Nafari, Anne Katrine Ravnanger, Mina Martine Frey, Nadia Skauli, Knut Sindre Åbjørsbråten, Lena Catherine Roth, Mahmood Amiry-Moghaddam, Erlend A Nagelhus, Ole Petter Ottersen, Inger Lise Bogen, Anna E Thoren, Rune Enger
Waste from the brain has been shown to be cleared via the perivascular spaces through the so-called glymphatic system. According to this model the cerebrospinal fluid (CSF) enters the brain in perivascular spaces of arteries, crosses the astrocyte endfoot layer, flows through the parenchyma collecting waste that is subsequently drained along veins. Glymphatic clearance is dependent on astrocytic aquaporin-4 (AQP4) water channels that are highly enriched in the endfeet. Even though the polarized expression of AQP4 in endfeet is thought to be of crucial importance for glymphatic CSF influx, its role in extracellular solute clearance has only been evaluated using non-quantitative fluorescence measurements...
March 26, 2024: Fluids and Barriers of the CNS
https://read.qxmd.com/read/38518543/mri-index-of-glymphatic-system-mediates-the-influence-of-locus-coeruleus-on-cognition-in-parkinson-s-disease
#29
JOURNAL ARTICLE
Xinhui Wang, Pei Huang, Ewart Mark Haacke, Peng Wu, Xiaobing Zhang, Huihui Zhang, Zenghui Cheng, Rongbiao Tang, Fangtao Liu, Yu Liu, Xiaofeng Shi, Peng Liu, Youmin Zhang, Zhijia Jin, Shengdi Chen, Naying He, Fuhua Yan
INTRODUCTION: Although locus coeruleus (LC) has been demonstrated to play a critical role in the cognitive function of Parkinson's disease (PD), the underlying mechanism has not been elucidated. The objective was to investigate the relationship among LC degeneration, cognitive performance, and the glymphatic function in PD. METHODS: In this retrospective study, 71 PD subjects (21 with normal cognition; 29 with cognitive impairment (PD-MCI); 21 with dementia (PDD)) and 26 healthy controls were included...
March 15, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38515515/assessing-interstitial-fluid-dynamics-in-type-2-diabetes-mellitus-and-prediabetes-cases-through-diffusion-tensor-imaging-analysis-along-the-perivascular-space
#30
JOURNAL ARTICLE
Rukeye Tuerxun, Koji Kamagata, Yuya Saito, Christina Andica, Kaito Takabayashi, Wataru Uchida, Seina Yoshida, Junko Kikuta, Hiroki Tabata, Hitoshi Naito, Yuki Someya, Hideyoshi Kaga, Mari Miyata, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Shigeki Aoki
BACKGROUND AND PURPOSE: Glymphatic system in type 2 diabetes mellitus (T2DM) but not in the prodrome, prediabetes (Pre-DM) was investigated using diffusion tensor image analysis along the perivascular space (DTI-ALPS). Association between glymphatic system and insulin resistance of prominent characteristic in T2DM and Pre-DM between is yet elucidated. Therefore, this study delves into the interstitial fluid dynamics using the DTI-ALPS in both Pre-DM and T2DM and association with insulin resistance...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38512676/detection-of-glymphatic-outflow-of-tau-from-brain-to-cerebrospinal-fluid-in-mice
#31
JOURNAL ARTICLE
Kazuhisa Ishida, Kaoru Yamada
Glymphatic system denotes a brain-wide pathway that eliminates extracellular solutes from brain. It is driven by the flow of brain interstitial fluid (ISF) and cerebrospinal fluid (CSF) via perivascular spaces. Glymphatic convective flow is driven by cerebral arterial pulsation, which is facilitated by a water channel, aquaporin-4 (AQP4) expressed in astrocytic end-foot processes. Since its discovery, the glymphatic system receives a considerable scientific attention due to its pivotal role in clearing metabolic waste as well as neurotoxic substances such as amyloid b peptide...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38512675/a-method-to-collect-cerebrospinal-fluid-from-mouse-cisterna-magna-to-determine-extracellular-tau-levels
#32
JOURNAL ARTICLE
Kazuhisa Ishida, Kaoru Yamada
Despite being a cytoplasmic protein abundant in neurons, tau is detectable in various extracellular fluids. In addition to being passively released from dying/degenerating neurons, tau is also actively released from living neurons in a neuronal activity-dependent mechanism. In vivo, tau released from neurons first appears in brain interstitial fluid (ISF) and subsequently drains into cerebrospinal fluid (CSF) by glymphatic system. Changes in CSF tau levels alter during the course of AD pathogenesis and are considered to predict the disease-progression of AD...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38512439/aqp4-endocytosis-lysosome-degradation-mediated-by-mmp-9-%C3%AE-dg-involved-in-diabetes-cognitive-impairment
#33
JOURNAL ARTICLE
Ye Yuan, Wei Peng, Jingna Lei, Yi Zhao, Beiyu Zhao, Yan Li, Jin Wang, Qiumin Qu
Cognitive impairment is considered to be one of the important comorbidities of diabetes, but the underlying mechanisms are widely unknown. Aquaporin-4 (AQP4) is the most abundant water channel in the central nervous system, which plays a neuroprotective role in various neurological diseases by maintaining the function of glymphatic system and synaptic plasticity. However, whether AQP4 is involved in diabetes-related cognitive impairment remains unknown. β-dystroglycan (β-DG), a key molecule for anchoring AQP4 on the plasma membrane of astrocytes and avoiding its targeting to lysosomes for degradation, can be cleaved by matrix metalloproteinase-9 (MMP-9)...
March 21, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38501315/glymphatic-system-dysfunction-predicts-amyloid-deposition-neurodegeneration-and-clinical-progression-in-alzheimer-s-disease
#34
JOURNAL ARTICLE
Shu-Yi Huang, Ya-Ru Zhang, Yu Guo, Jing Du, Peng Ren, Bang-Sheng Wu, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
INTRODUCTION: Although glymphatic function is involved in Alzheimer's disease (AD), its potential for predicting the pathological and clinical progression of AD and its sequential association with core AD biomarkers is poorly understood. METHODS: Whole-brain glymphatic activity was measured by diffusion tensor image analysis along the perivascular space (DTI-ALPS) in participants with AD dementia (n = 47), mild cognitive impairment (MCI; n = 137), and normal controls (n = 235) from the Alzheimer's Disease Neuroimaging Initiative...
March 19, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38493535/enlarged-choroid-plexus-in-relapsing-remitting-multiple-sclerosis-may-lead-to-brain-structural-changes-through-the-glymphatic-impairment
#35
JOURNAL ARTICLE
Yan Xie, Hongquan Zhu, Yihao Yao, Chengxia Liu, Shaolong Wu, Yan Zhang, Wenzhen Zhu
OBJECTIVES: To investigate the potential link among choroid plexus (CP) volume, glymphatic clearance and brain structural change in relapsing-remitting multiple sclerosis (RRMS) patients. MATERIALS AND METHODS: Sixty-five RRMS patients and 48 healthy controls (HC) underwent MRI examination. The diffusion tensor image analysis along the perivascular space (DTI-ALPS) was calculated to reflect glymphatic system function. The brain structure volume and DTI-ALPS index were compared between RRMS and HC...
March 11, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38492884/ginkgolide-b-can-alleviate-spinal-glymphatic-system-dysfunction-and-provide-neuroprotection-in-pdn-rats-by-inhibiting-matrix-metalloproteinase-9
#36
JOURNAL ARTICLE
Jiang Li, Shuaiying Jia, Yuehan Song, Wenmei Xu, Jingyan Lin
The glymphatic system plays a crucial role in maintaining optimal central nervous system (CNS) function by facilitating the removal of metabolic wastes. Aquaporin-4 (AQP4) protein, predominantly located on astrocyte end-feet, is a key pathway for metabolic waste excretion. β-Dystroglycan (β-DG) can anchor AQP4 protein to the end-feet membrane of astrocytes and can be cleaved by matrix metalloproteinase (MMP)-9 protein. Studies have demonstrated that hyperglycemia upregulates MMP-9 expression in the nervous system, leading to neuropathic pain...
March 14, 2024: Neuropharmacology
https://read.qxmd.com/read/38490679/choroid-plexus-calcifications-are-not-associated-with-putative-markers-of-glymphatic-dysfunction-a-population-study-in-middle-aged-and-older-adults
#37
JOURNAL ARTICLE
Pablo R Castillo, Vishal Patel, Robertino M Mera, Denisse A Rumbea, Oscar H Del Brutto
BACKGROUND AND PURPOSE: Recent studies have suggested an association between dysfunction of the choroid plexus and the glymphatic system. However, information is inconclusive. Following a population-based study design, we aimed to assess the association between choroid plexus calcifications (CPCs)-as a surrogate of choroid plexus dysfunction-and severity and progression of putative markers of glymphatic dysfunction, including white matter hyperintensities (WMH) of presumed vascular origin and abnormally enlarged basal ganglia perivascular spaces (BG-PVS)...
March 15, 2024: Neuroradiology Journal
https://read.qxmd.com/read/38484877/reduced-coupling-between-global-signal-and-cerebrospinal-fluid-inflow-in-patients-with-depressive-disorder-a-resting-state-functional-mri-study
#38
JOURNAL ARTICLE
Yanyu Zhang, Bo Peng, Shengli Chen, Qunjun Liang, Yingli Zhang, Shiwei Lin, Ziyun Xu, Jiayun Zhang, Gangqiang Hou, Yingwei Qiu
BACKGROUND: Depressed patients often suffer from sleep disturbance, which has been recognized to be responsible for glymphatic dysfunction. The purpose of this study was to investigate the coupling strength of global blood‑oxygen-level-dependent (gBOLD) signals and cerebrospinal fluid (CSF) inflow dynamics, which is a biomarker for glymphatic function, in depressed patients and to explore its potential relationship with sleep disturbance by using resting-state functional MRI. METHODS: A total of 138 depressed patients (112 females, age: 34...
March 12, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38484035/circadian-mechanisms-in-brain-fluid-biology
#39
REVIEW
Velia S Vizcarra, Ryann M Fame, Lauren M Hablitz
The brain is a complex organ, fundamentally changing across the day to perform basic functions like sleep, thought, and regulating whole-body physiology. This requires a complex symphony of nutrients, hormones, ions, neurotransmitters and more to be properly distributed across the brain to maintain homeostasis throughout 24 hours. These solutes are distributed both by the blood and by cerebrospinal fluid. Cerebrospinal fluid contents are distinct from the general circulation because of regulation at brain barriers including the choroid plexus, glymphatic system, and blood-brain barrier...
March 15, 2024: Circulation Research
https://read.qxmd.com/read/38481063/cognitive-impairment-is-related-to-glymphatic-system-dysfunction-in-pediatric-multiple-sclerosis
#40
JOURNAL ARTICLE
Monica Margoni, Elisabetta Pagani, Alessandro Meani, Paolo Preziosa, Damiano Mistri, Mor Gueye, Lucia Moiola, Massimo Filippi, Maria Assunta Rocca
OBJECTIVE: The aim of this study was to investigate whether, compared to pediatric healthy controls (HCs), the glymphatic system is impaired in pediatric multiple sclerosis (MS) patients according to their cognitive status, and to assess its association with clinical disability and MRI measures of brain structural damage. METHODS: Sixty-five pediatric MS patients (females = 62%; median age = 15.5 [interquartile range, IQR = 14...
March 13, 2024: Annals of Neurology
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