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Opiate research

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https://www.readbyqxmd.com/read/28325819/new-connections-getting-the-good-without-the-bad-opiate-edition
#1
Wei Wong
Researchers identify strategies to limit the adverse effects and liabilities of opioid receptor-targeting drugs.
March 21, 2017: Science Signaling
https://www.readbyqxmd.com/read/28306680/anaesthesia-in-patients-with-liver-disease
#2
Malgorzata H Starczewska, Wint Mon, Peter Shirley
PURPOSE OF REVIEW: The purpose of this review is to summarize the most recent up to date research data and recommendations regarding anaesthetic management of patients with liver disease undergoing surgery. The incidence of chronic liver disease (CLD) continues to rise and perioperative mortality and morbidity remains unacceptably high in this group. Meticulous preoperative assessment and carefully planned anaesthetic management are vital in improving outcomes in patients with liver disease undergoing surgery...
March 16, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28301858/anti-nerve-growth-factor-therapy-increases-spontaneous-day-night-activity-in-mice-with-orthopedic-surgery-induced-pain
#3
Lisa A Majuta, Jean-Marc G Guedon, Stefanie A T Mitchell, Michael H Ossipov, Patrick W Mantyh
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are 2 of the most common and successful surgical interventions to relieve osteoarthritis pain. Control of postoperative pain is critical for patients to fully participate in the required physical therapy which is the most influential factor in effective postoperative knee rehabilitation. Currently, opiates are a mainstay for managing postoperative orthopedic surgery pain including TKA or THA pain. Recently, issues including efficacy, dependence, overdose, and death from opiates have made clinicians and researchers more critical of use of opioids for treating nonmalignant skeletal pain...
April 2017: Pain
https://www.readbyqxmd.com/read/28291977/five-factor-model-personality-profiles-the-differences-between-alcohol-and-opiate-addiction-among-females
#4
Diana Raketic, Jasmina V Barisic, Snezana M Svetozarevic, Tatjana Gazibara, Darija Kisic Tepavcevic, Srdjan D Milovanovic
BACKGROUND: The prevalence of female alcohol and substance abusers has markedly increased. The main objective of this research was to explore personality profiles among females who had alcohol and opiate dependence. AIM: The aim of the study is to analyse if there is differences in personality profiles of females addicted to alcohol and opiates. We hypothesized that there might be significant differences in personality profiles among subgroups of women who present with alcohol and opiate use disorders...
March 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28281909/positive-association-of-personal-distress-with-testosterone-in-opiate-addicted-patients
#5
Katrin Stange, Mathias Krüger, Eva Janke, Ralf Lichtinghagen, Stefan Bleich, Thomas Hillemacher, Annemarie Heberlein
BACKGROUND: Clinical studies report that substance addictions are associated with sociocognitive impairments. Regarding opiate addicted patients, the few existing studies point to deficits regarding empathic abilities. Previous research suggests that testosterone might be a relevant biomarker of these impairments. AIMS: We aimed to investigate whether opiate addicted patients show specific impairments in emotional (empathic concern, personal distress) and cognitive empathy compared to healthy controls...
March 10, 2017: Journal of Addictive Diseases
https://www.readbyqxmd.com/read/28242532/polysubstance-use-in-treatment-seekers-who-inject-amphetamine-drug-use-profiles-injecting-practices-and-quality-of-life
#6
Peter J Kelly, Laura D Robinson, Amanda L Baker, Frank P Deane, Rebecca McKetin, Suzie Hudson, Carol Keane
BACKGROUND: The injection of amphetamine is becoming increasingly common. However, there has been a lack of research examining people who inject amphetamine as the primary drug of use, limiting the potential to ensure services address the unique needs of this group. The current study used latent class analysis to identify classes of polydrug use among people who report injecting amphetamine during the past 12months. It also examined differences between classes and drug use patterns, injecting practices, quality of life and psychological distress...
February 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28240418/analysis-of-drugs-of-abuse-in-cerumen-correlation-of-postmortem-analysis-results-with-those-for-blood-urine-and-hair
#7
Sylvia I Meier, Sarah C Koelzer, Manfred Schubert-Zsilavecz, Stefan W Toennes
The evaluation of drug and alcohol abuse is a major subject of forensic toxicology. Assessment of drug abstinence currently requires the analysis of urine or hair. In the present study cerumen, a mixture of sebum and sweat, was tested as an alternative. Postmortem samples (blood, urine, hair and cerumen from 38 corpses) were analyzed using liquid chromatography and gas chromatography, each coupled to mass spectrometry (LC-MS, GC-MS). The results were compared. In all cases of recent drug use (i.e. detection of opiates, amphetamine and derivatives, cocaine, methadone and diazepam or their metabolites in blood) the corresponding cerumen was positive...
February 27, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28239317/analysis-of-the-clinical-indications-for-opiate-use-in-inflammatory-bowel-disease
#8
Youran Gao, Sundas Khan, Meredith Akerman, Keith Sultan
BACKGROUND/AIMS: Opiate use for inflammatory bowel disease (IBD), particularly high-dose (HD) use, is associated with increased mortality. It's assumed that opiate use is directly related to IBD-related complaints, although this hasn't been well defined. Our goal was to determine the indications for opiate use as a first step in developing strategies to prevent or decrease opiate use. METHODS: A retrospective cohort was formed of adults who were diagnosed with IBD and for whom outpatient evaluations from 2009 to 2014 were documented...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28212516/sex-disparities-in-substance-abuse-research-evaluating-23-years-of-structural-neuroimaging-studies
#9
Kimberly E Lind, Eric J Gutierrez, Dorothy J Yamamoto, Michael F Regner, Sherry A McKee, Jody Tanabe
BACKGROUND: Sex differences in brain structure and clinical course of substance use disorders underscores the need to include women in structural brain imaging studies. The NIH has supported the need for research to address sex differences. We evaluated female enrollment in substance abuse structural brain imaging research and the methods used to study sex differences in substance effects. METHODS: Structural brain imaging studies published through 2016 (n=230) were evaluated for number of participants by sex and substance use status and methods used to evaluate sex differences...
January 31, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28161142/factors-associated-with-using-opiates-while-under-extended-release-naltrexone-blockade-a-descriptive-pilot-study
#10
Brantley P Jarvis, Anthony DeFulio, Lauren Long, August F Holtyn, Annie Umbricht, Michael Fingerhood, George E Bigelow, Kenneth Silverman
BACKGROUND AND AIM: Extended-release naltrexone (XR-NTX) blocks the effects of opioids for 4weeks, yet many patients continue to use them. To learn more about why this occurs, we collected self-reports on subjective effects and drug use factors from participants' most recent heroin/opiate use while under XR-NTX blockade. METHODS: Participants (n=38) were unemployed, heroin-dependent adults enrolled in a randomized controlled trial evaluating employment-based incentives to promote adherence to XR-NTX...
December 24, 2016: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28131792/interleukin-1-signaling-in-the-basolateral-amygdala-is-necessary-for-heroin-conditioned-immunosuppression
#11
Lee W Hutson, Christina L Lebonville, Meghan E Jones, Rita A Fuchs, Donald T Lysle
Heroin administration suppresses the production of inducible nitric oxide (NO), as indicated by changes in splenic inducible nitric oxide synthase (iNOS) and plasma nitrate/nitrite. Since NO is a measure of host defense against infection and disease, this provides evidence that heroin can increase susceptibility to pathogens by directly interacting with the immune system. Previous research in our laboratory has demonstrated that these immunosuppressive effects of heroin can also be conditioned to environmental stimuli by repeatedly pairing heroin administration with a unique environmental context...
January 25, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28072916/a-preliminary-study-examining-women-s-physical-health-and-nonmedical-prescription-opioid-use-in-a-recovering-framework
#12
Katherine R Marks, Carl G Leukefeld
BACKGROUND: There is a growing need for research on women recovering from nonmedical prescription opioid use. A paradigm shift is to focus on wellness and factors that support, rather than hinder, recovering women. For example, although physical health is impacted by nonmedical prescription opioid use, improved health may be a strength-based factor among recovering women. The aim of this preliminary study was to examine physical health in a recovering framework as women begin recovering from nonmedical prescription opiate use...
March 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28051842/the-use-of-auricular-acupuncture-in-opioid-use-disorder-a-systematic-literature-review
#13
REVIEW
Tanya E Baker, Grace Chang
BACKGROUND AND OBJECTIVES: Opioid use disorder (OUD) is a chronic disease with significant personal, societal, and public health consequences. Even for the minority who receive the most effective evidence-based treatments, morbidity, and mortality remain significant. These facts, along with the recovery movement calling for individualized, holistic, culturally sensitive care, have led to the exploration of adjunctive interventions including acupuncture. Despite hundreds of international trials, however, there is a lack of consensus regarding its efficacy in OUD due in large part to methodological issues of trials to date...
December 2016: American Journal on Addictions
https://www.readbyqxmd.com/read/28032481/safety-tolerability-and-antihypertensive-effect-of-ser100-an-opiate-receptor-like-1-orl-1-partial-agonist-in-patients-with-isolated-systolic-hypertension
#14
Ilkka Kantola, Mika Scheinin, Trygve Gulbrandsen, Nils Meland, Knut T Smerud
The purpose of the present trial was to evaluate safety, tolerability, and effect on systolic blood pressure (SBP) of SER100 in a small group of patients with isolated systolic hypertension (ISH) in treatment with at least 1 antihypertensive drug. Eligible patients were randomized to either SER100 (10 mg) or placebo in a crossover design, and 2 doses were given subcutaneously (SC), 8 hours apart, on 2 consecutive days. On all treatment days patients were monitored with an ambulatory blood pressure measurement device for 12 daytime hours...
December 29, 2016: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28012859/endogenous-opiates-and-behavior-2015
#15
REVIEW
Richard J Bodnar
This paper is the thirty-eighth consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2015 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior, and the roles of these opioid peptides and receptors in pain and analgesia, stress and social status, tolerance and dependence, learning and memory, eating and drinking, drug abuse and alcohol, sexual activity and hormones, pregnancy, development and endocrinology, mental illness and mood, seizures and neurologic disorders, electrical-related activity and neurophysiology, general activity and locomotion, gastrointestinal, renal and hepatic functions, cardiovascular responses, respiration and thermoregulation, and immunological responses...
February 2017: Peptides
https://www.readbyqxmd.com/read/28009632/anti-nerve-growth-factor-therapy-increases-spontaneous-day-night-activity-in-mice-with-orthopedic-surgery-induced-pain
#16
Lisa A Majuta, Jean-Marc G Guedon, Stefanie A T Mitchell, Michael H Ossipov, Patrick W Mantyh
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are two of the most common and successful surgical interventions to relieve osteoarthritis pain. Control of postoperative pain is critical for patients to fully participate in the required physical therapy which is the most influential factor in effective postoperative knee rehabilitation. Currently opiates are a mainstay for managing postoperative orthopedic surgery pain including TKA/THA pain. Recently, issues including efficacy, dependence, overdose and death from opiates have made clinicians and researchers more critical of use of opioids for treating non-malignant skeletal pain...
December 15, 2016: Pain
https://www.readbyqxmd.com/read/28000024/current-practice-patterns-for-management-of-vulvodynia-in-the-united-states
#17
Lannah L Lua, Yvette Hollette, Prathamesh Parm, Gayle Allenback, Vani Dandolu
PURPOSE: To evaluate the current practice patterns for the management of vulvodynia in the United States (US) and to estimate healthcare costs related to this condition. METHODS: Truven MarketScan Commercial Claims and Encounters databases for years 2009-2013 were utilized for analysis. The study cohort included women, 18 years or older, with a diagnosis of vulvodynia (ICD-9 625.70), who had been continuously enrolled for 360 days from the date of diagnosis. Measures included the most common prescriptions, primary procedures, associated diagnoses, as well as net healthcare costs...
December 20, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27984493/anti-nerve-growth-factor-therapy-increases-spontaneous-day-night-activity-in-mice-with-orthopedic-surgery-induced-pain
#18
Lisa A Majuta, Jean-Marc G Guedon, Stefanie A T Mitchell, Michael H Ossipov, Patrick W Mantyh
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are two of the most common and successful surgical interventions to relieve osteoarthritis pain. Control of postoperative pain is critical for patients to fully participate in the required physical therapy which is the most influential factor in effective postoperative knee rehabilitation. Currently opiates are a mainstay for managing postoperative orthopedic surgery pain including TKA/THA pain. Recently, issues including efficacy, dependence, overdose and death from opiates have made clinicians and researchers more critical of use of opioids for treating non-malignant skeletal pain...
December 15, 2016: Pain
https://www.readbyqxmd.com/read/27956447/towards-understanding-and-managing-chronic-cough
#19
REVIEW
Imran Satia, Huda Badri, Bashar Al-Sheklly, Jaclyn Ann Smith, Ashley A Woodcock
Chronic cough is a common and troublesome condition affecting approximately 12% of the general population. It is associated with poor quality of life with psychological, social and physical consequences. Patients typically complain of a dry irritating cough, driven by a strong urge to cough associated with a sensation or irritation located in the throat. Treatment of potential 'causes', ie asthma, gastro-oesophageal reflux disease and rhino-sinusitis, may produce a complete or partial response, but the response of some patients to opiates and alpha-2-delta ligand antagonists (gabapentin and pregabalin) supports the concept that this is primarily a neurological disorder, characterised by hyper-responsiveness of the nerves...
December 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/27919289/correlates-of-sex-trading-among-male-non-injecting-drug-users-in-myanmar-a-cross-sectional-study
#20
Yu Mon Saw, Thu Nandar Saw, Kyi Mar Wai, Krishna C Poudel, Hla Hla Win
BACKGROUND: Sex trading is a recognized risk factor for human immune deficiency virus infection and other sexually transmitted infections among non-injecting drug users (NIDUs). However, very little research has addressed the factors associated with sex trading among male NIDUs in Myanmar. METHODS: A cross-sectional study was conducted from January to February 2010 using the respondent-driven sampling method. In total, 210 NIDUs aged between 18 and 49 years, with no history of injecting drug use, and who used non-injected illicit drugs in the last 6 months were recruited...
December 5, 2016: Harm Reduction Journal
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