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Opiate research

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https://www.readbyqxmd.com/read/29788455/a-10-yr-analysis-of-chronic-pelvic-pain-and-chronic-opioid-therapy-in-the-women-veteran-population
#1
Sara B Cichowski, Rebecca G Rogers, Yuko Komesu, Erin Murata, Clifford Qualls, Allison Murata, Glen Murata
Introduction: Chronic pelvic pain (CPP) affects an estimated 30% of women Veterans. Previous research shows high rates of narcotic abuse in the women Veteran population. Narcotics are not recommended for the treatment of CPP. Understanding how CPP impacts narcotic prescribing in the women Veteran population is critical to addressing the public health crisis of opioid abuse. Our objective was to compare chronic opioid therapy (COT) prescribed 5 yr prior to and following CPP diagnosis and to identify predictors of COT as well as adverse events associated with COT...
May 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29775728/opioid-free-anaesthesia-why-and-how-a-contextual-analysis
#2
REVIEW
Patrice Forget
If the use of natural opiates, such as opium, is more than millennial, the history of synthetic opioids begins after 1950, with the development of the so-called 'modern' anaesthetic techniques. In 1962, in Belgium, the use of fentanyl, the first synthetic opioid for use in anaesthesia, is described. Subsequently, the use of opioids at high doses during surgery became common. However, over the last twenty years, many studies have questioned this practice, highlighting the many unknowns as the side effects of these molecules...
May 15, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29748103/gabapentin-as-an-adjunct-to-standard-postoperative-pain-management-protocol-in-lower-extremity-surgery
#3
REVIEW
P Andrew Crisologo, Erik K Monson, Said A Atway
Postoperative pain is a problem that plagues physicians and has since the dawn of the surgical arts. Many interventions are available and used as the standard such as preoperative local anesthetic blocks, opiates, both oral and intravenous, and nonsteroidal antiinflammatory drugs. Although the temptation often exists to increase the postoperative opiate dose, opiate abuse is an increasing problem. This abuse has fueled the search for nonopiate pain adjuncts. Gabapentinoids have been shown to both decrease postoperative pain and, secondarily, decrease opiate dependence...
May 7, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29693427/characteristics-and-experiences-of-buprenorphine-naloxone-use-among-polysubstance-users
#4
Robert Walker, T K Logan, Quintin T Chipley, Jaime Miller
BACKGROUND: With a rise in overdoses and medical emergencies related to opioids, buprenorphine-naloxone (bup-nx) is seen as a preferred treatment for opioid dependence. However, the research examining experiences with bup-nx among polysubstance users who may or may not be opioid dependent has been limited. OBJECTIVES: The purpose of the study was to examine use, characteristics of users, and experiences of bup-nx use among polysubstance users entering drug-free recovery programs...
April 25, 2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29649094/methadone-maintenance-treatment-a-15-year-retrospective-study-in-split-dalmatia-county-croatia
#5
Davorka Sutlovic, Zeljko Kljucevic, Livia Sliskovic, Helena Susnjar, Ivo Viskovic, Marija Definis-Gojanovic
BACKGROUND: The aim of this retrospective study is to use existing epidemiological data on patients in methadone maintenance treatment in Split Dalmatia County from 2001 to 2015 in order to evaluate the substitution treatment system and policy of opiate addicts treatment, the epidemiological trend, and risk of overdose mortality. In addition, we would like to highlight the problem of poor control of methadone therapy, and thus the possibility of selling methadone. The result is a greater number of deaths caused by methadone in people who were not in methadone therapy...
April 11, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29616150/methadone-treatment-of-opiate-addiction-a-systematic-review-of-comparative-studies
#6
REVIEW
Shahid Ali, Barira Tahir, Shagufta Jabeen, Madeeha Malik
Opiate misuse is a chronic relapsing disease that has become an epidemic in the United States. Methadone is the mainstay of treatment for opiate addiction and has been researched widely. Recently, new avenues of treatment have been researched and developed. The objective of this review is to study methadone in comparison to other pharmacological options available or being considered for opiate addiction treatment through a methodical search and review of evidence provided by recent clinical trials conducted in this regard...
July 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29602191/perinatal-substance-use-residential-instability-and-negative-behavioral-outcomes-among-adolescents-lessons-from-the-maternal-lifestyle-study
#7
Brandi P Cotton, Matthew C Lohman, Jessica M Brooks, Linda L LaGasse
PROBLEM: Both housing instability and prenatal substance use are known risk factors for behavioral problems among adolescents. METHODS: The purpose of this study was to investigate the association between residential instability (residential mobility and homelessness) and delinquent behaviors among adolescents enrolled in the maternal lifestyle study (MLS), a 16-year research study that explored short-term and long-term effects of in-utero exposure to cocaine and/or opiates (N = 736)...
March 30, 2018: Journal of Child and Adolescent Psychiatric Nursing
https://www.readbyqxmd.com/read/29601550/exploration-of-the-use-of-new-psychoactive-substances-by-individuals-in-treatment-for-substance-misuse-in-the-uk
#8
Rosalind Gittins, Amira Guirguis, Fabrizio Schifano, Ian Maidment
Substance misuse services need to meet the growing demand and needs of individuals using new psychoactive substances (NPS). A review of the literature identified a paucity of research regarding NPS use by these individuals and UK guidelines outline the need for locally tailored strategies. The purpose of this qualitative study was to identify and explore key themes in relation to the use of NPS by individuals receiving community treatment for their substance use. Electronic records identified demographics and semi-structured interviews were undertaken...
March 30, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29584496/evaluating-drugged-driving-effects-of-exemplar-pain-and-anxiety-medications
#9
Timothy L Brown, Gary Milavetz, Gary Gaffney, Andrew Spurgin
OBJECTIVE: Distracted and drug-influenced driving presents a major risk for traffic safety morbidity and mortality. As part of an ongoing research program, we examined the effects of a commonly prescribed combination of medications for pain relief: alprazolam, a benzodiazepine, and a hydrocodone preparation, a combination opiate and acetaminophen, on a simulated driving protocol. METHODS: Utilizing a within-subjects design, we recruited 8 healthy experienced drivers without major physical and psychological histories...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29578199/initial-treatment-dropout-in-patients-with-substance-use-disorders-attending-a-tertiary-care-de-addiction-centre-in-north-india
#10
Debasish Basu, Abhishek Ghosh, Siddharth Sarkar, Bichitra Nanda Patra, B N Subodh, Surendra Kumar Mattoo
Background & objectives: Dropout from substance use disorders treatment is associated with poor outcomes. Although many factors have been associated with an early dropout of patients, the reasons for dropping out of treatment prematurely remain poorly understood particularly in the Indian context. This study was aimed to study socio-demographic and clinical variables predicting initial dropout of patients attending a tertiary care de-addiction treatment centre in north India. Methods: Information was extracted from the records of consecutive newly registered patients from January 2011 to December 2014...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29558163/distress-tolerance-and-pain-experience-among-young-adults
#11
Andrew H Rogers, Jafar Bakhshaie, Nubia A Mayorga, Joseph W Ditre, Michael J Zvolensky
Pain and pain related problems affect a significant proportion of the United States population. Past research suggests that emotional distress is associated with more severe and disabling pain experience. Yet, it is less clear how individual reactions to distress are related to pain experience. Distress tolerance, defined as the perceived ability to withstand cognitive, affective, or physical distress, is an individual difference factor that may be particularly important to understanding the experience of pain...
March 20, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29535241/moving-away-from-the-tip-of-the-pyramid-screening-and-brief-intervention-for-risky-alcohol-and-opioid-use-in-underserved-patients
#12
Kamilla L Venner, Victoria Sánchez, Jacqueline Garcia, Robert L Williams, Andrew L Sussman
PURPOSE: Rates of risky substance use and substance use disorders are high in primary-care practices, yet the adoption of universal screening and brief intervention (SBI) has been slow and uneven. This study aimed to describe SBI-related attitudes, practices, and perspectives regarding practice change among medical providers in a minority-majority state. METHODS: We conducted a cross-sectional, on-line survey of a practice-based research network of medical providers serving predominantly Hispanic/Latinx and Native American patients in rural and urban settings...
March 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29527046/kilpauk-mental-hospital-the-bethlem-of-south-asia-a-recall-of-its-history-prior-to-1970
#13
O Somasundaram, Ponnudurai Ratnaraj
Period of Custodial Care Only: The magnificent "Institute of Mental Health" has its history almost from 1795 when the East India company appointed Surgeon Valentine Conolly to be in charge of a "House for accommodating persons of unsound mind." After a few transitions, backed by a government order for the construction of a lunatic asylum in a 66 1/2 acre site, the asylum started functioning from 1871. The period of about six decades from its inception could be referred to as "the period of custodial care...
February 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29520899/pain-in-parkinson-s-disease-facts-and-uncertainties
#14
REVIEW
A Antonini, M Tinazzi, G Abbruzzese, A Berardelli, K R Chaudhuri, G Defazio, J Ferreira, P Martinez-Martin, C Trenkwalder, O Rascol
Pain is one of the most common and troublesome non-motor symptoms of Parkinson's disease (PD). It can appear at any time during the disease and is often present before diagnosis. However, there is little or no consensus on its definition. An expert group of clinicians with relevant research experience met to review the existing evidence and to identify gaps in our understanding leading towards AUTHOR: 'understanding towards' has been changed to 'understanding leading towards'. Please check and confirm that this is appropriate an optimized therapy of pain in PD...
March 9, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29498782/factors-associated-with-pain-severity-pain-interference-and-perception-of-functional-abilities-independent-of-joint-status-in-us-adults-with-hemophilia-multivariable-analysis-of-the-pain-functional-impairment-and-quality-of-life-p-fiq-study
#15
Christine L Kempton, Tyler W Buckner, Moshe Fridman, Neeraj N Iyer, David L Cooper
INTRODUCTION: Levels of pain and dysfunction appear to differ among people with hemophilia despite similar levels of joint disease. OBJECTIVE: To determine patient characteristics that influence pain and function independent of joint status. METHODS: US adults with hemophilia completed a survey that included information on clinical characteristics, demographics, and patient-reported outcome instruments assessing pain (Brief Pain Inventory v2 Short Form [BPI]), functional impairment (Hemophilia Activities List [HAL]), and health status (EQ-5D-5L)...
April 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29474119/description-and-outcomes-of-a-buprenorphine-maintenance-treatment-program-integrated-within-prevention-point-philadelphia-an-urban-syringe-exchange-program
#16
Marcus A Bachhuber, Cole Thompson, Ann Prybylowski, José Benitez, Silvana Mazzella, David Barclay
BACKGROUND: Syringe exchange programs are uniquely positioned to offer treatment services to interested clients. Prevention Point Philadelphia recently expanded to offer buprenorphine maintenance treatment through its Stabilization, Treatment, and Engagement Program (STEP). OBJECTIVE: To describe the STEP model of care and report treatment outcomes. METHODS: Retrospective chart review of patients enrolled in STEP (October 2011 to August 2014)...
February 23, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29468091/surgical-technical-evidence-review-for-elective-total-joint-replacement-conducted-for-the-ahrq-safety-program-for-improving-surgical-care-and-recovery
#17
REVIEW
Christopher P Childers, Anaar E Siletz, Emily S Singer, Claire Faltermeier, Q Lina Hu, Clifford Y Ko, Gregory J Golladay, Stephen L Kates, Elizabeth C Wick, Melinda Maggard-Gibbons
Background: Use of enhanced recovery pathways (ERPs) can improve patient outcomes, yet national implementation of these pathways remains low. The Agency for Healthcare Research and Quality (AHRQ; funder), the American College of Surgeons, and the Johns Hopkins Medicine Armstrong Institute for Patent Safety and Quality have developed the Safety Program for Improving Surgical Care and Recovery-a national effort to catalyze implementation of practices to improve perioperative care and enhance recovery of surgical patients...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29453925/impact-of-opioid-therapy-on-gonadal-hormones-focus-on-buprenorphine
#18
REVIEW
Anjali Varma, Mamta Sapra, Ali Iranmanesh
Objective The USA is in the midst of an opioid crisis. Understanding the impact of opioids and commonly used treatments for opioid dependence is essential for clinicians and researchers in order to educate and treat the nation's growing population with opioid use disorders. As a relatively new treatment for opioid dependence, buprenorphine is gaining popularity to the extent of becoming not only a preferred approach to the maintenance of opiate addiction, but also an option for chronic pain management. The purpose of this report is to review the available evidence on the endocrine effects of buprenorphine, particularly as it relates to the hypothalamic-pituitary-gonadal (HPG) axis, which is controversial and not fully defined...
February 17, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29445515/telementoring-with-project-echo-a-pilot-study-in-europe
#19
Clíona Ní Cheallaigh, Aisling O'Leary, Shay Keating, Aileen Singleton, Sheila Heffernan, Eamon Keenan, Lisa Robson, Jess Sears, John Moloney, Sanjeev Arora, Colm Bergin, Suzanne Norris
The Extension of Community Healthcare Outcomes (ECHO) project is a novel educational intervention designed in New Mexico to transfer subspecialty knowledge about hepatitis C virus (HCV) to primary care providers, thereby increasing patient access to HCV care. The ECHO model has been shown to deliver educational benefits and to result in good treatment outcomes for HCV-infected individuals in the USA; however, this approach has not been assessed in a European setting. We sought to evaluate the feasibility, acceptability and implementation of the ECHO model in Ireland using a pilot study...
July 2017: BMJ Innovations
https://www.readbyqxmd.com/read/29422449/attention-bias-in-individuals-with-addictive-disorders-systematic-review-protocol
#20
Melvyn Zhang, JiangBo Ying, Guo Song, Roger Cm Ho, Daniel Ss Fung, Helen Smith
BACKGROUND: Globally, substance disorders, particularly that of opiate use, cannabis use, and stimulant use disorders, are highly prevalent. Psychological treatments are an integral aspect of intervention, but a proportion of individuals still relapse despite having received such an intervention. Recently, the dual-process theory proposed that the unconscious processes of attention biases are responsible for these relapses. Prior meta-analyses have reported the presence of attention bias in alcohol and tobacco use disorders...
February 8, 2018: JMIR Research Protocols
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