keyword
https://read.qxmd.com/read/38189794/vasculitis-panniculitis-mimicking-unresolved-diabetic-foot-ulcer
#21
JOURNAL ARTICLE
Debby Christiana Soemitha, Deshinta Putri Mulya, Hemi Sinorita
SUMMARY: Diabetes foot ulcer (DFU) is a common long-term complication of diabetes. Intractable chronic wounds to standard care of diabetic foot raise the question of whether other factors intervene in disease development. We report a case of a 54-year-old male patient who came to Sardjito General Hospital with leg pain and previous history of multiple debridement and amputation for DFU referred from a remote hospital yet no improvement was evident in the surrounding lesion following treatment...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38175492/neuromodulation-techniques-in-chronic-refractory-coccydynia-a-narrative-review
#22
REVIEW
Sarvenaz Rahimibarghani, Richard Morgan, Jose Juan Diaz
Refractory coccydynia is a condition characterized by severe coccygeal pain and poses a challenging management dilemma for clinicians. Advancements in neuromodulation (NM) technology have provided benefits to people experiencing chronic pain that is resistant to standard treatments. This review aims to summarize the spectrum of current NM techniques employed in the treatment of refractory coccydynia along with their effectiveness. A review of studies in the scientific literature from 2012 to 2023 was conducted, revealing a limited number of case reports...
February 2024: Pain and Therapy
https://read.qxmd.com/read/38153470/spinal-cord-high-frequency-stimulation-the-current-experience-and-future-directions
#23
JOURNAL ARTICLE
Alessandro Izzo, Manuela D'Ercole, Alessandro Rapisarda, Filippo Maria Polli, Filomena Fuggetta, Alessandro Olivi, Massimiliano Visocchi, Nicola Montano
Spinal cord stimulation (SCS) is a neuromodulation technology that has emerged as a valid treatment for chronic intractable neuropathic pain. After conventional tonic SCS, new waveforms of stimulation, like high frequency (HF), have proved that they can provide safe and effective pain relief. In addition, SCS is now being utilized more broadly as a potential treatment for a range of indications, including motor disorders and spasticity. Our study presents a retrospective analysis of 20 patients with heterogenous aetiologies of neuropathic pain treated with HF stimulation, after a standardized protocol in a temporary trial...
2023: Acta Neurochirurgica. Supplement
https://read.qxmd.com/read/38153468/spinal-cord-stimulation-meets-them-all-an-effective-treatment-for-different-pain-conditions-our-experience-and-literature-review
#24
JOURNAL ARTICLE
Giuseppe Roberto Giammalva, Federica Paolini, Lapo Bonosi, Flavia Meccio, Luigi Basile, Francesca Graziano, Mariangela Pino, Rosa Maria Gerardi, Giuseppe Emmanuele Umana, Domenico Gerardo Iacopino, Rosario Maugeri
IntroductionSpinal Cord Stimulation (SCS) is an emerging minimally invasive technique which uses neuromodulation to manage different forms of intractable pain. SCS is a well-established option for the treatment of various pain conditions, and nowadays, indications are ever increasing.Materials and MethodsIn this study, we present our case series of 49 patients who underwent SCS at our Institution for the treatment of pain from different etiologies, and discuss our 10-year experience in SCS. For the purpose of this study, we also performed a systematic review of current indications and new perspectives in SCS...
2023: Acta Neurochirurgica. Supplement
https://read.qxmd.com/read/38145318/outcome-after-total-pancreatectomy-with-islet-autotransplantation-a-european-single-center-study
#25
JOURNAL ARTICLE
Klara Fröberg, Asif Halimi, Miroslav Vujasinovic, José Caballero-Corbalan, Urban Arnelo, Ernesto Sparrelid, Olle Korsgren, Johannes-Matthias Löhr, Torbjörn Lundgren, Poya Ghorbani
BACKGROUND AND AIMS: Chronic pancreatitis may cause intractable abdominal pain, with total pancreatectomy sometimes being the last resort. To mitigate the subsequent diabetes, total pancreatectomy can be followed by islet autotransplantation (TP-IAT). The primary aim of this study was to assess the outcomes in patients undergoing TP-IAT at Karolinska University Hospital with respect to safety, postoperative complications, and islet graft function. A secondary aim was to compare liver to skeletal muscle as autotransplantation sites...
December 25, 2023: Scandinavian Journal of Surgery: SJS
https://read.qxmd.com/read/38143907/chronic-intermittent-tachycardia-as-a-consequence-of-vagus-nerve-injury-after-anterior-cervical-discectomy-and-fusion-case-report-of-a-previously-unreported-complication
#26
Erik Werheim, Zachary Sokol, Neha Mody, Justice Owusu-Agyei
BACKGROUND: The surgical approach of an anterior cervical discectomy and fusion (ACDF) navigates many important neurologic and vascular structures in the neck. More frequently reported complications are dysphagia, postoperative hematoma, cerebrospinal fluid leaks, and dysphonia. CASE DESCRIPTION: This case report details an ACDF in a 49-year-old female with intractable neck pain and radicular symptoms. Following the procedure, she developed intermittent tachycardia at rest, which worsened with exertion...
December 2023: N Am Spine Soc J
https://read.qxmd.com/read/38142769/dissecting-neural-circuits-from-rostral-ventromedial-medulla-to-spinal-trigeminal-nucleus-bidirectionally-modulating-craniofacial-mechanical-sensitivity
#27
JOURNAL ARTICLE
Yang Xue, Siyi Mo, Yuan Li, Ye Cao, Xiaoxiang Xu, Qiufei Xie
Chronic craniofacial pain is intractable and its mechanisms remain unclarified. The rostral ventromedial medulla (RVM) plays a crucial role in descending pain facilitation and inhibition. It is unclear how the descending circuits from the RVM to spinal trigeminal nucleus (Sp5) are organized to bidirectionally modulate craniofacial nociception. We used viral tracing, in vivo optogenetics, calcium signaling recording, and chemogenetic manipulations to investigate the structure and function of RVM-Sp5 circuits...
December 22, 2023: Progress in Neurobiology
https://read.qxmd.com/read/38137549/neuromodulation-for-craniofacial-pain-and-headaches
#28
REVIEW
Ray J Pak, Jun B Ku, Alaa Abd-Elsayed
Headaches and facial pain are highly prevalent diseases but are often difficult to treat. Though there have been significant advances in medical management, many continue to suffer from refractory pain. Neuromodulation has been gaining interest for its therapeutic purposes in many chronic pain conditions, including headaches and facial pain. There are many potential targets of neuromodulation for headache and facial pain, and some have more robust evidence in favor of their use than others. Despite the need for more high-quality research, the available evidence for the use of neuromodulation in treating headaches and facial pain is promising...
December 16, 2023: Biomedicines
https://read.qxmd.com/read/38077782/topical-fosaprepitant-for-the-treatment-of-ocular-pain-and-inflammation
#29
JOURNAL ARTICLE
Giuseppe Suanno, Matteo Pederzolli, Romina Mayra Lasagni Vitar, Philippe Fonteyne, Giulio Ferrari
PURPOSE: To assess whether topical administration of fosaprepitant improves intractable chronic ocular pain and inflammation. METHODS: We report three clinical cases of female patients with drug-resistant ocular pain associated with inflammatory diseases of the ocular surface. The patients were treated for 3 (case 1) and 4 (cases 2-3) weeks with fosaprepitant eyedrops (0.1 mg/mL for case 1; 10 mg/mL for case 2-3). Patients were then followed up for at least 3 weeks...
December 2023: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/38069511/involvement-of-spinal-nadph-oxidase-4-and-endoplasmic-reticulum-stress-in-morphine-tolerant-rats
#30
JOURNAL ARTICLE
Xuyang Xiao, Jingjie Yang, Qian Bai, Zhitao Wang, Yan Chen, Yue Si, Yaowei Xu, Zhisong Li, Huilian Bu
Morphine tolerance (MT) is currently a challenging issue related to intractable pain treatment. Studies have shown that reactive oxygen species (ROSs) derived from NADPH oxidase (NOX) and produced in response to endoplasmic reticulum (ER) stress participate in MT development. However, which NOX subtype initiates ER stress during MT development is unclear. NOX4 is mainly expressed on intracellular membranes, such as the ER and mitochondrial membranes, and its sole function is to produce ROS. Whether NOX4 is activated during MT development and the mechanisms underlying the association between NOX4 and ER stress during this process still need to be confirmed...
December 8, 2023: Journal of Neurochemistry
https://read.qxmd.com/read/38026468/opioids-prescribing-among-patients-with-zoster-related-pain-in-real-life-a-retrospective-cohort-study-based-on-the-clinical-database
#31
JOURNAL ARTICLE
Wei Su, Dong Liu, Pingliang Yang, Ling Ye
PURPOSE: The aim of this study was to analysis of the opioid use of opioid native zoster-related pain (ZRP) patients to evaluate the impact of opioid use on pain control and quality of life improvement based on the clinical database. PATIENTS AND METHODS: We conducted a retrospective cohort study to identify opioid native patients who were hospitalized in the pain department between May 1, 2020, and May 1, 2021. The primary outcomes were persistent opioid use after discharge, visual analogue scale (VAS) at the admission, VAS remission rate during hospitalization, VAS score and quality of life at follow-up...
2023: Journal of Pain Research
https://read.qxmd.com/read/37983131/use-of-fosaprepitant-for-management-of-suspected-antimicrobial-associated-nausea-a-case-report
#32
JOURNAL ARTICLE
Brandon Perkovich, Rabia S Atayee, Jennifer S Kim, Tamara Rubenzik
Intractable nausea can occur in numerous settings. We report on a 49-year-old woman with a past medical history of cystic fibrosis (CF) with chronic hypoxia, chronic nausea, complex infection history and frequent hospitalizations who was admitted to an academic medical center with a CF exacerbation. Her chronic nausea worsened with the use of antimicrobials, and she was unable to tolerate dopamine or serotonin antagonist antiemetics. Nausea persisted despite the use of benzodiazepines and antihistamines. She was given a one-time dose of fosaprepitant 150 mg intravenously (IV) with marked improvement of her nausea...
November 20, 2023: Journal of Pain & Palliative Care Pharmacotherapy
https://read.qxmd.com/read/37976486/results-from-a-prospective-clinical-study-us-npower-evaluating-a-miniature-spinal-cord-stimulator-for-the-management-of-chronic-intractable-pain
#33
JOURNAL ARTICLE
Mehul J Desai, Tejal Raju, Chheany Ung, Sailesh Arulkumar, Leo Kapural, Mayank Gupta, Kasra Amirdelfan, David Rosenfeld, Aaron Calodney, Dawood Sayed, Ajay Antony, Sean Li, Ramana Naidu, Joel Ackerman, Robert Ball, Michael Fishman, Peter Staats, Gary Heit, Shilpa Kottalgi, James Makous
BACKGROUND: Chronic, intractable, neuropathic pain is readily treatable with spinal cord stimulation (SCS). Technological advancements, including device miniaturization, are advancing the field of neuromodulation. OBJECTIVES: We report here the results of an SCS clinical trial to treat chronic, low back and leg pain, with a micro-implantable pulse generator (micro-IPG). STUDY DESIGN: This was a single-arm, prospective, multicenter, postmarket, observational study...
November 2023: Pain Physician
https://read.qxmd.com/read/37967833/myalgia-where-does-it-come-from
#34
JOURNAL ARTICLE
Hsun-Hua Lee, Chih-Cheng Chen
Myalgia (also called muscle pain or muscle ache) is a symptom associated with many diseases, including fibromyalgia, neurodegenerative diseases, degenerative spine diseases, etc. Myalgia is a major medical problem affecting 60~85% of the population (lifetime prevalence). However, our understanding of chronic myalgia is still limited and effective treatment for intractable myalgia like fibromyalgia is still lacking. Although multifactorial, one known source of muscle pain is tissue acidosis. Experimental muscle pain can be induced by the intramuscular infusion of a buffered acidic solution in humans...
December 30, 2023: Acta Neurologica Taiwanica
https://read.qxmd.com/read/37966349/dorsal-root-ganglion-stimulation-to-treat-chronic-shoulder-pain-a-case-report
#35
JOURNAL ARTICLE
Kenneth B Chapman, Connor Tupper, Tariq Yousef, Noud van Helmond
A 67-year-old man presented with severe 9 of 10 intractable pain of the left shoulder joint after arthroplasty and revision surgeries, with associated weakness, atrophy, and limited range of motion in all directions. Dorsal root ganglion stimulation (DRG-S) at the left C4, C5, and C6 levels was used after failed conservative and interventional measures, resulting in significant improvement in pain, function, and quality of life measures through 6 months postimplantation. Larger studies should examine if DRG-S is effective in treating chronic arthritic joint pain as well as chronic postsurgical pain of the shoulder that is not predominantly neuropathic...
November 1, 2023: A&A Practice
https://read.qxmd.com/read/37963235/a-phenotypic-screening-platform-for-chronic-pain-therapeutics-using-all-optical-electrophysiology
#36
JOURNAL ARTICLE
Pin W Liu, Hongkang Zhang, Christopher A Werley, Monika Pichler, Steven J Ryan, Caitlin L Lewarch, Jane Jacques, Jennifer Grooms, Jean Ferrante, Guangde Li, Dawei Zhang, Nate Bremmer, Adam Barnett, Romina Chantre, Amy E Elder, Adam E Cohen, Luis A Williams, Graham T Dempsey, Owen B McManus
Chronic pain associated with osteoarthritis (OA) remains an intractable problem with few effective treatment options. New approaches are needed to model the disease biology and to drive discovery of therapeutics. We present an in vitro model of OA pain, where dorsal root ganglion (DRG) sensory neurons were sensitized by a defined mixture of disease-relevant inflammatory mediators, here called Sensitizing PAin Reagent Composition or SPARC. Osteoarthritis-SPARC components showed synergistic or additive effects when applied in combination and induced pain phenotypes in vivo...
November 14, 2023: Pain
https://read.qxmd.com/read/37956343/surgical-management-of-pain-or-infection-secondary-to-calciphylaxis-a-wound-center-s-experience-and-algorithmic-multidisciplinary-approach
#37
JOURNAL ARTICLE
Lauren E Berger, Alice C Bell, Samuel S Huffman, Daisy L Spoer, Ilana G Margulies, Kevin G Kim, Cameron M Akbari, John S Steinberg, Christopher E Attinger, Karen K Evans
BACKGROUND: The role of surgical management of calciphylaxis remains understudied. OBJECTIVE: This article reports a case series and algorithmic approach to the multidisciplinary management of calciphylaxis. METHODS: A single-center retrospective review of all adult patients with calciphylaxis treated surgically between January 2010 and November 2022 was performed. RESULTS: Eleven patients met inclusion criteria. The average age was 50...
October 2023: Wounds: a Compendium of Clinical Research and Practice
https://read.qxmd.com/read/37954846/dysregulated-neuromodulation-in-the-anterior-cingulate-cortex-in-chronic-pain
#38
REVIEW
Kevin Lançon, Philippe Séguéla
Chronic pain is a significant global socioeconomic burden with limited long-term treatment options. The intractable nature of chronic pain stems from two primary factors: the multifaceted nature of pain itself and an insufficient understanding of the diverse physiological mechanisms that underlie its initiation and maintenance, in both the peripheral and central nervous systems. The development of novel non-opioidergic analgesic approaches is contingent on our ability to normalize the dysregulated nociceptive pathways involved in pathological pain processing...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37954627/a-rare-intrathecal-pump-complication-caused-by-prolonged-seroma-leading-to-a-potential-pump-pocket-fill-a-near-miss
#39
Teddy Gerges, Angelina Mavropoulos, Danielle Levin, Thuan Dao, Martin Acquadro
Intrathecal drug delivery systems have been used with increasing frequency in patients with chronic intractable pain. Common complications of intrathecal drug delivery systems include surgical bleeding, spinal cord injury, fractured or migrated catheter, meningitis, pump failure, granuloma formation, cerebral spinal fluid leak, and hygroma formation. We present a rare near-miss case that could have led to the inadvertent filling of an intrathecal pump pocket with a high concentration of narcotic and local anesthetic...
November 2023: Curēus
https://read.qxmd.com/read/37934398/prokineticin-2-participates-in-chronic-constriction-injury-triggered-neuropathic-pain-and-anxiety-via-regulated-by-nf-%C3%AE%C2%BAb-in-nucleus-accumbens-shell-in-rats
#40
JOURNAL ARTICLE
Wenting Wang, Meng Yuan, Yaowei Xu, Jingjie Yang, Xiaoling Wang, Yifan Zhou, Zhixiang Yu, Zhongyuan Lu, Yiming Wang, Chenge Hu, Qian Bai, Zhisong Li
Neuropathic pain (NP) is an intractable pain that results from primary nervous system injury and dysfunction. Herein, we demonstrated in animal models that peripheral nerve injury induced enhanced pain perception and anxiety-like behaviors. According to previous reports, nucleus accumbens (NAc) shell is required for complete expression of neuropathic pain behaviors and mood alternations, we found the elevated mRNA and protein level of Prokineticin-2 (Prok2) in the NAc shell after Chronic Constriction Injury (CCI)...
November 7, 2023: Molecular Neurobiology
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