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Essential hypertension

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https://www.readbyqxmd.com/read/28646394/the-antihypertensive-efficacy-of-the-triple-fixed-combination-of-perindopril-indapamide-and-amlodipine-the-results-of-the-petra-study
#1
György Ábrahám, Csaba András Dézsi
INTRODUCTION: The etiology of essential hypertension is multifactorial. Therefore, treatment with combinations of antihypertensive agents acting on multiple targets is necessary for successful therapy in the majority of patients. According to the experience and clinical data accumulated so far, combination therapy with three agents from different pharmacological classes is required in approx. 30% of patients in order to achieve long-term blood pressure control. The primary objective of the PETRA study was to evaluate the efficacy of blood pressure (BP) control with once daily administration of the different dosage strengths of the once-daily, triple fixed combination of perindopril, indapamide, and amlodipine...
June 23, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28642328/leukocyte-diversity-in-resolving-and-nonresolving-mechanisms-of-cardiac-remodeling
#2
REVIEW
Bochra Tourki, Ganesh Halade
In response to myocardial infarction (MI), time-dependent leukocyte infiltration is critical to program the acute inflammatory response. Post-MI leukocyte density, residence time in the infarcted area, and exit from the infarcted injury predict resolving or nonresolving inflammation. Overactive or unresolved inflammation is the primary determinant in heart failure pathology post-MI. Here, our review describes supporting evidence that the acute inflammatory response also guides the generation of healing and regenerative mediators after cardiac damage...
June 22, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28641368/glomerular-hyperfiltration-in-obese-african-american-hypertensive-patients-is-associated-with-elevated-urinary-mitochondrial-dna-copy-number
#3
Alfonso Eirin, Ahmed Saad, John R Woollard, Luis A Juncos, David A Calhoun, Hui Tang, Amir Lerman, Stephen C Textor, Lilach O Lerman
BACKGROUND: Glomerular hyperfiltration may contribute to the high incidence of renal disease in Obese African Americans essential hypertensive (ObAAEH) patients, but the precise mechanisms responsible for renal injury have not been elucidated. Mitochondria are important determinants of renal injury in hypertension, and increased levels of mitochondrial DNA (mtDNA) in the urine may indicate renal mitochondrial injury. We hypothesized that urine mtDNA copy numbers would be higher in ObAAEH compared to Caucasian essential hypertensive (CEH) patients...
June 14, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28640647/influence-of-prkch-gene-polymorphism-on-antihypertensive-response-to-amlodipine-and-telmisartan
#4
Zan-Ling Zhang, Miao-Miao Zhu, Hui-Lan Li, Li-Hong Shi, Xiao-Ping Chen, Jia Luo, Jin-Feng Zhao
This study aimed to evaluate the effect of PRKCH rs2230500 genetic polymorphism on efficacy of amlodipine and telmisartan for patients with hypertension. A total of 136 essential hypertension (EH) patients were treated with amlodipine (70 patients) or telmisartan (66 patients), respectively. Genetic polymorphism was genotyped by Sanger sequencing. Both baseline and post-treatment blood pressure (BP) and heart rate were measured to evaluate the influence of genetic polymorphism on the antihypertensive response...
June 22, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28637401/relationship-between-ambulatory-arterial-stiffness-index-aasi-and-night-day-blood-pressure-ratio-in-essential-hypertensives
#5
Domenico Di Raimondo, Alessandra Casuccio, Rosangela Di Liberti, Gaia Musiari, Valentina Zappulla, Alessandra D'angelo, Antonio Pinto
BACKGROUND: Ambulatory Arterial Stiffness Index (AASI) has been proposed as an indirect and simpler method to estimate the Arterial Stiffness (AS). AASI, calculated from a set of data collected during a 24-hours ambulatory blood pressure monitoring (ABPM), is defined as 1 minus the regression slope of diastolic on systolic blood pressure (BP) values. For a given increase in diastolic BP, the increase in systolic BP is smaller in a compliant compared to a stiff artery; the stiffer the arterial tree, the closer AASI is to 1...
June 21, 2017: Current Hypertension Reviews
https://www.readbyqxmd.com/read/28636457/notch-signaling-in-lung-diseases
#6
Jiehan Jiang, Kui Xiao, Ping Chen
NOTCH is a fundamental signaling system that regulates normal embryonic development and tissue homeostasis in adult life. NOTCH receptor is a single-pass transmembrane protein normally triggered via direct cell-to-cell contact, in which NOTCH ligands bind the extracellular domain of the receptor, inducing γ-secretase cleavage and release of intracellular domain. The intracellular domain binds to the transcriptional effector RBPJκ to activate transcription of target genes that regulate cell differentiation, patterning, and morphogenesis during embryonic development and adult life...
June 21, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28634813/long-term-excessive-selenium-supplementation-induces-hypertension-in-rats
#7
Denise Grotto, Maria Fernanda Hornos Carneiro, Michele Mazzaron de Castro, Solange Cristina Garcia, Fernando Barbosa Junior
Selenium (Se) is an essential trace element involved in several biological pathways, naturally found in rocks, soils, and food. Even though the daily requirement of Se is achieved through a balanced diet, the use of Se supplements has been frequent. Due to the risk of toxic effects of having Se in excess, supplementation is still under debate. The aim was to evaluate the effects of long-term Se supplementation upon systolic blood pressure (SBP) and redox status of rats exposed to sodium selenite. Male Wistar rats were exposed to 2 and 6 mg/L of sodium selenite in drinking water for 85 days...
June 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28632449/prevalence-of-essential-hypertension-and-its-complications-among-chinese-population-at-high-altitude
#8
Le Yue, Zhiqing Fan, Lin Sun, Wei Feng, Jingjie Li
Yue Le, Zhiqing Fan, Lin Sun, Wei Feng, and Jingjie Li. Prevalence of essential hypertension and its complications among Chinese population at high altitude. High Alt Med Biol. 18:140-144, 2017. OBJECTIVES: This study examined the prevalence of essential hypertension (EH) and its complications among Chinese population at different altitude regions in Qinghai province. METHODS: This cross-sectional analysis used data from 2000 residents living in the area with two different latitudes for more than 20 years, using 1:1 pairing mode...
June 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28627632/association-of-single-nucleotide-polymorphisms-in-the-5-upstream-region-of-the-c4bpa-gene-with-essential-hypertension-in-a-northeastern-han-chinese-population
#9
Xueyan Liu, Chao Jiang, Ping Yang
A previous study of the authors using microarray analysis indicated that the expression of complement component 4 binding protein (C4BP)A is upregulated in essential hypertension (EH) patients, but the association between C4BPA variations and EH has not yet been clearly demonstrated. Since the 5' upstream region is known to serve important roles in the gene expression regulation, the present study aimed to identify and analyze the association of single nucleotide polymorphisms (SNPs) in the 5' upstream region between the C4BPA gene with EH in a case‑control study among a northeastern Han Chinese population through direct sequencing as well as genotype detection...
June 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28624548/glucocorticoids-and-gut-bacteria-the-galf-hypothesis-in-the-metagenomic-era
#10
REVIEW
David J Morris, Jason M Ridlon
A new concept is emerging in biomedical sciences: the gut microbiota is a virtual 'organ' with endocrine function. Here, we explore the literature pertaining to the role of gut microbial metabolism of endogenous adrenocorticosteroids as a contributing factor in the etiology of essential hypertension. A body of literature demonstrates that bacterial products of glucocorticoid metabolism are absorbed into the portal circulation, and pass through the kidney before excretion into urine. Apparent Mineralocorticoid Excess (AME) syndrome patients were found to have congenital mutations resulting in non-functional renal 11β-hydroxysteroid dehydrogenase-2 (11β-HSD2) and severe hypertension often lethal in childhood...
June 14, 2017: Steroids
https://www.readbyqxmd.com/read/28621557/a-positive-association-between-the-human-tissue-kallikerin-gene-a2233c-polymorphism-and-blood-pressure-response-to-benazepril
#11
Zhe Hong, Liying Pan, Jiali Fei, Zhangqing Ma, Zongyuan Hong
BACKGROUND: It is generally believed that essential hypertension is influenced by both genetic and environmental factors, as well as their interactions. Tissue kallikrein encoded by the tissue kallikrein gene (KLK1) is a key serine proteinase of kallikrein-kinin system, which is capable of generating potent vasactive peptides, kinins, by selective cleavage of the kininogen substrate. It was reported that the A2233 → C polymorphism in KLK1 gene is associated with essential hypertension...
June 16, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28621445/nutritional-and-functional-bioactivity-value-of-selected-azorean-macroalgae-ulva-compressa-ulva-rigida-gelidium-microdon-and-pterocladiella-capillacea
#12
Lisete Paiva, Elisabete Lima, Ana Isabel Neto, Massimo Marcone, José Baptista
This study presents information on the biochemical composition (dry weight basis), nutritional aspects, and angiotensin I-converting enzyme (ACE) inhibitory properties of selected macroalgae (Ulva compressa, Ulva rigida, Gelidium microdon, and Pterocladiella capillacea) from Azores. Moisture content was very high (83.2% to 90.0% of fresh weight). Total dietary fiber (33.7% to 41.0%) that presented a good balance of both soluble and insoluble fibers (15.5% to 19.2% and 18.2% to 21.8%, respectively) was the most abundant component in these macroalgae...
June 16, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28620629/pediatric-hypertension-provider-perspectives
#13
Jennifer K Bello, Nivedita Mohanty, Victoria Bauer, Sarah S Rittner, Goutham Rao
Pediatric hypertension is a risk for adult cardiovascular disease, making early detection important. The prevalence of pediatric essential hypertension is rising due to the increased prevalence of obesity. Though guidelines for screening, diagnosis, evaluation, and management are available, there are barriers to accurate diagnosis of pediatric hypertension, including lack of knowledge and complexity of blood pressure standards. We aimed to gain insights into reasons for low rates of diagnosis and treatment from primary care providers...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28620066/mitochondrial-complex-iv-subunit-4-isoform-2-is-essential-for-acute-pulmonary-oxygen-sensing
#14
Natascha Sommer, Maik Huttemann, Oleg Pak, Susan Scheibe, Fenja Knöpp, Christopher Sinkler, Monika Malczyk, Mareike Gierhardt, Azadeh Esfandiary, Simone Kraut, Felix T Jonas, Christine Veith, Siddhesh Aras, Akylbek Sydykov, Nasim Alebrahimdehkordi, Klaudia Giehl, Matthias Hecker, Ralf P Brandes, Werner Seeger, Friedrich Grimminger, Hossein A Ghofrani, Ralph T Schermuly, Lawrence I Grossman, Norbert Weissmann
Rationale: Acute pulmonary oxygen sensing is essential to avoid life-threatening hypoxemia via hypoxic pulmonary vasoconstriction (HPV) which matches perfusion to ventilation. Hypoxia-induced mitochondrial superoxide release has been suggested as critical step in the signaling pathway underlying HPV. However, the identity of the primary oxygen sensor and mechanism of superoxide release in acute hypoxia, as well as its relevance for chronic pulmonary oxygen sensing remains unresolved. Objective: To investigate the role of the pulmonary specific isoform 2 of subunit 4 of mitochondrial complex IV (Cox4i2) and the subsequent mediators superoxide and hydrogen peroxide for pulmonary oxygen sensing and signaling...
June 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28616414/basnef-model-intervention-on-blood-pressure-modification-among-hypertensive-diabetic-patients
#15
Azar Tol, Hadiseh Farhandi, Bahram Mohebbi, Roya Sadeghi
BACKGROUND: Prevalence of hypertension in patients with type 2 diabetes is two to three times more than nondiabetic patients. This study aimed at assessing the impacts of an educational program based on BASNEF Model on blood pressure modification among diabetic patients with hypertension. MATERIALS AND METHODS: Two hundred patients with type 2 diabetes were recruited in an educational intervention study among two groups. The intervention group attended a 3-month self-care educational program regarding hypertension control in addition to the regular care presented for both the groups...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28616291/intensive-blood-pressure-control-in-patients-with-acute-type-b-aortic-dissection-raid-study-protocol-for-randomized-controlled-trial
#16
REVIEW
Jian-Cang Zhou, Nan Zhang, Zhong-Heng Zhang, Ting-Ting Wang, Yue-Feng Zhu, Hui Kang, Wei-Min Zhang, Dong-Lin Li, Wei-Dong Li, Zhen-Jie Liu, Xi-Min Qian, Ming-You Zhang, Jue Wang, Mi Zhou, Zhi-Tao Yang, Yun-Xian Yu, Hang-Yang Li, Jian Zhang, Yong-Gang Wang, Jian-Ping Gao, Lin Ling, Kong-Han Pan
BACKGROUND: Blood pressure control is an essential therapy for patients with acute type B aortic dissection (ABAD) and should be maintained throughout the entire treatment. Thus, vast majority current guidelines recommend control the blood pressure to lower than 140/90 mmHg. Theoretically, a much lower target may further decrease the risk of propagation of dissection. However, some argued that too lower blood pressure would compromise the organ perfusion. Thus, there is no unanimous optimal target for blood pressure in patients with ABAD so far...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28616044/decreased-fibrinolytic-activity-is-associated-with-carotid-artery-stiffening-in-arterial-hypertension
#17
Cristiana Catena, Gianluca Colussi, Valentina Fagotto, Leonardo A Sechi
BACKGROUND: A prothrombotic state is associated with the presence and severity of organ damage in hypertensive patients. In these patients, evidence of subclinical carotid functional changes anticipates major cardiovascular events. The aim of this study was to investigate the association of hemostatic markers with carotid artery stiffness in hypertension. MATERIALS AND METHODS: In 116 untreated essential hypertensive patients recruited at a referral center in the University of Udine, we assessed common carotid artery stiffness by B-mode ultrasonography and measured plasma fibrinogen, D-dimer, plasminogen activator inhibitor-1 (PAI-1), and homocysteine by the currently available methods...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28614115/trafficking-and-regulation-of-the-nkcc2-cotransporter-in-the-thick-ascending-limb
#18
Kerim Mutig
PURPOSE OF REVIEW: The kidney Na-K-2Cl cotransporter (NKCC2) is essential for urinary concentration and renal electrolyte handling. Loss of function mutations in the NKCC2 gene cause urinary salt and potassium wasting, whereas excessive NKCC2 function has been linked to high blood pressure. Loop diuretics, targeting the transporter, are instrumental for relieving edema or hypertension. This review focuses on intrinsic mechanisms regulating NKCC2 activity at the posttranslational level, namely its trafficking and phosphorylation...
June 12, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28614094/plasma-renin-activity-to-plasma-aldosterone-concentration-ratio-correlates-with-night-time-and-pulse-pressures-in-essential-hypertensive-patients-treated-with-angiotensin-converting-enzyme-inhibitors-at1-blockers
#19
Francesco Spannella, Federico Giulietti, Paolo Balietti, Elisabetta Borioni, Francesca E Lombardi, Maddalena Ricci, Guido Cocci, Laura Landi, Riccardo Sarzani
OBJECTIVES: Angiotensin-converting enzyme inhibitors (ACE-I) and AT1 blockers (ARB) are commonly used antihypertensive drugs, but several factors may affect their effectiveness. We evaluated the associations between ambulatory blood pressure (BP) monitoring (ABPM) parameters and plasma renin activity (PRA)-to-plasma aldosterone concentration (PAC) ratio (RAR) to test renin-angiotensin-aldosterone system inhibition in essential hypertensive patients treated with ACE-I or ARB for at least 12 months...
June 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28613098/combined-treatment-of-irbesartan-and-diltiazem-ameliorates-endothelium-dependent-vasodilatation-in-hypertensives
#20
Tingting Zhou, Xiaodong Huang, Xiaoqi Cai, Liangdi Xie
OBJECTIVE: Endothelial function is of prognostic importance for hypertensives. The aim of this study was to investigate the effects of irbesartan combined with diltiazem on the endothelium-dependent vasodilatation in essential hypertensive (EH) patients in China. METHODS: A total of 150 Chinese hypertensives aged from 40 to 80 years old were assigned into three groups: irbesartan treated(150 mg/d, n = 46), diltiazem treated (90 mg/d, n = 51), and combined therapy group (irbesartan 150 mg/d+ diltiazem 90 mg/d, n = 53)...
June 14, 2017: Clinical and Experimental Hypertension: CHE
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