keyword
MENU ▼
Read by QxMD icon Read
search

Chronic Neuralgia, PHN

keyword
https://www.readbyqxmd.com/read/29117658/treatment-of-postherpetic-neuralgia-with-5-topical-lidocaine-plaster-%C3%A2-experience-from-a-small-county-hospital-case-report
#1
Maša Kontić, Višnja Vičić-Hudorović, Narcis Hudorović
Postherpetic neuralgia (PHN) characterized by chronic neuropathic pain is a common complication of herpes zoster. We investigated the efficacy, safety and cost of treating refractory chronic neuropathic pain with 5% topical lidocaine plaster (TLP) in a female patient attending pain unit at a small county hospital. An 80-year-old female diagnosed with PHN presented with severe left intercostal allodynia and hyperalgesia up to the root of the fourth to tenth thoracic dermatome. We administered the well established first- and second-line specific medications for PHN, but treatment regimens were not efficient...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28856112/the-efficacy-of-systemic-lidocaine-in-the-management-of-chronic-pain-a-literature-review
#2
REVIEW
Fardin Yousefshahi, Oana Predescu, Juan Francisco Asenjo
CONTEXT: Despite recent advances in the understanding of the chronic pain concept, its diagnosis and management remains a daily challenge for clinicians and patients. Based on the published literature, this review discusses and tries to organize the current knowledge and the up-to-date clinical experience about the efficacy and safety of the use of intravenous lidocaine in treatment and prevention of chronic pain. EVIDENCE ACQUISITION: To prepare this narrative review, we performed an in depth literature review using the PubMed searching engine...
June 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28757922/earlier-treatment-improves-the-chances-of-complete-relief-from-postherpetic-neuralgia
#3
Dong Hee Kang, Su Young Kim, Hyuck Goo Kim, Jung Hyun Park, Tae Kyun Kim, Kyung Hoon Kim
BACKGROUND: As herpes zoster progresses via postherpetic neuralgia (PHN) to well-established PHN, it presents its recalcitrant nature to the treatment. At this point, the well-established PHN is fixed as a non-treatable, but manageable chronic painful neuropathic disorder. This study evaluated the incidence of complete relief from PHN according to PHN duration at their first visit, and the other factors influencing it. METHODS: A retrospective chart review was performed on patients with PHN at a university-based pain clinic over 7 years...
July 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28727713/local-brain-activity-differences-between-herpes-zoster-and-postherpetic-neuralgia-patients-a-resting-state-functional-mri-study
#4
Song Cao, Ying Li, Wenwen Deng, Bangyong Qin, Yi Zhang, Peng Xie, Jie Yuan, Buwei Yu, Tian Yu
BACKGROUND: Herpes zoster (HZ) can develop into postherpetic neuralgia (PHN), both of which are painful diseases. PHN patients suffer chronic pain and emotional disorders. Previous studies showed that the PHN brain displayed abnormal activity and structural change, but the difference in brain activity between HZ and PHN is still not known. OBJECTIVES: To identify regional brain activity changes in HZ and PHN brains with resting-state functional magnetic resonance imaging (rs-fMRI) technique, and to observe the differences between HZ and PHN patients...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28727712/intervertebral-foramen-injection-of-ozone-relieves-mechanical-allodynia-and-enhances-analgesic-effect-of-gabapentin-in-animal-model-of-neuropathic-pain
#5
Wen-Jun Luo, Fan Yang, Fei Yang, Wei Sun, Wei Zheng, Xiao-Liang Wang, Fang-Fang Wu, Jiang-Lin Wang, Jia-Shuang Wang, Su-Min Guan, Jun Chen
BACKGROUND: In a 5-year follow-up study in a hospital in southern China, it was shown that intervertebral foramen (IVF) injection of ozone at the involved segmental levels could significantly alleviate paroxysmal spontaneous pain and mechanical allodynia in patients with chronic, intractable postherpetic neuralgia (PHN) and improve the quality of life. However, so far no proof-of-concept studies in animals have been available. OBJECTIVE: This study was designed to investigate whether IVF ozone has an analgesic effect on animal models of neuropathic and inflammatory pain...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28549561/lateral-thalamic-control-of-nociceptive-response-after-whisker-pad-injection-of-varicella-zoster-virus
#6
Phillip R Kramer, Crystal Stinson, Mikhail Umorin, Mohong Deng, Mahesh Rao, Larry L Bellinger, Michael B Yee, Paul R Kinchington
Pain is a common complication of herpes zoster (HZ) infection which results from reactivation of a latent varicella zoster virus (VZV). A third of HZ patients' progress to a chronic pain state known as post herpetic neuralgia (PHN), and about a quarter of these patients' have orofacial pain. The mechanisms controlling the pain responses are not understood. Studies suggest central pathways involving the thalamus could control pain related to HZ, and studies in our lab suggest (VGAT) in the lateral thalamus influences orofacial pain...
July 25, 2017: Neuroscience
https://www.readbyqxmd.com/read/28514943/sex-differences-underlying-orofacial-varicella-zoster-associated-pain-in-rats
#7
Crystal Stinson, Mohong Deng, Michael B Yee, Larry L Bellinger, Paul R Kinchington, Phillip R Kramer
BACKGROUND: Most people are initially infected with varicella zoster virus (VZV) at a young age and this infection results in chickenpox. VZV then becomes latent and reactivates later in life resulting in herpes zoster (HZ) or "shingles". Often VZV infects neurons of the trigeminal ganglia to cause ocular problems, orofacial disease and occasionally a chronic pain condition termed post-herpetic neuralgia (PHN). To date, no model has been developed to study orofacial pain related to varicella zoster...
May 17, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28325536/self-reported-neuropathic-pain-characteristics-of-women-with-provoked-vulvar-pain-a-preliminary-investigation
#8
Emma Dargie, Ian Gilron, Caroline F Pukall
BACKGROUND: Provoked vestibulodynia (PVD) is a common chronic genital pain condition affecting approximately 12% of premenopausal women. Although parallels have been drawn between PVD and neuropathic pain (NP), no studies have examined self-reported NP characteristics in PVD. AIM: To explore pain symptoms that resemble NP reported by those with PVD and compare responses with those with an established NP condition. METHODS: Women with provoked vulvar pain (PVP; n = 65) completed online questionnaires designed to assess characteristics of NP...
April 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28223842/development-of-a-novel-algorithm-to-determine-adherence-to-chronic-pain-treatment-guidelines-using-administrative-claims
#9
Jay M Margolis, Nicole Princic, David M Smith, Lucy Abraham, Joseph C Cappelleri, Sonali N Shah, Peter W Park
OBJECTIVE: To develop a claims-based algorithm for identifying patients who are adherent versus nonadherent to published guidelines for chronic pain management. METHODS: Using medical and pharmacy health care claims from the MarketScan® Commercial and Medicare Supplemental Databases, patients were selected during July 1, 2010, to June 30, 2012, with the following chronic pain conditions: osteoarthritis (OA), gout (GT), painful diabetic peripheral neuropathy (pDPN), post-herpetic neuralgia (PHN), and fibromyalgia (FM)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28158166/abnormal-local-brain-activity-beyond-the-pain-matrix-in-postherpetic-neuralgia-patients-a-resting-state-functional-mri-study
#10
Song Cao, Ganjun Song, Yi Zhang, Peng Xie, Ye Tu, Ying Li, Tian Yu, Buwei Yu
BACKGROUND: Postherpetic neuralgia (PHN) patients suffer debilitating chronic pain, hyperalgesia, and allodynia, as well as emotional disorders such as insomnia, anxiety, and depression. The brain structure and functional basis of PHN are still not fully understood. OBJECTIVES: To identify the changes of regional brain activity in resting-state PHN patients using regional homogeneity (ReHo) and fractional aptitude of low-frequency fluctuation (fALFF) methods. Correlations between spontaneous pain intensity and ReHo or fALFF were analyzed...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28118257/provoked-vestibulodynia-a-comparative-examination-of-mental-health-sleep-sexual-functioning-and-relationship-adjustment
#11
Emma Dargie, Ian Gilron, Caroline Pukall
OBJECTIVES: Provoked vestibulodynia (PVD) is an idiopathic vulvar pain condition characterized by burning pain at the vaginal opening in response to contact or pressure. Previous research has established some of the psychosocial difficulties experienced by these patients, but direct comparisons with other pain conditions are needed. The purpose of this study was to compare women with PVD to those with post-herpetic neuralgia and pain-free control participants. METHODS: Participants were invited to complete an anonymous online survey consisting of sociodemographic questions and a range of validated measures...
January 21, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28088231/efficacy-of-gabapentin-for-prevention-of-postherpetic-neuralgia-study-protocol-for-a-randomized-controlled-clinical-trial
#12
Manuel Rullán, Oana Bulilete, Alfonso Leiva, Aina Soler, Antonia Roca, María José González-Bals, Patricia Lorente, Joan Llobera
BACKGROUND: Postherpetic neuralgia (PHN) is a chronic neuropathic pain that results from alterations of the peripheral nervous system in areas affected by the herpes zoster virus. The symptoms include pain, paresthesia, dysesthesia, hyperalgesia, and allodynia. Despite the availability of pharmacological treatments to control these symptoms, no treatments are available to control the underlying pathophysiology responsible for this disabling condition. METHODS/DESIGN: Patients with herpes zoster who are at least 50 years old and have a pain score of 4 or higher on a visual analogue scale (VAS) will be recruited...
January 14, 2017: Trials
https://www.readbyqxmd.com/read/27977069/biological-mechanism-of-post-herpetic-neuralgia-evidence-from-multiple-patho-psychophysiological-measures
#13
W W Peng, X L Guo, Q Q Jin, H Wei, X L Xia, Y Zhang, P C Huang, W C Wang, S L Li, J S Wang, J Chen, L Hu
BACKGROUND: Post-herpetic neuralgia (PHN), which develops after the resolution of a herpes zoster eruption, is an exceptionally drug-resistant neuropathic pain. The unsatisfactory management of PHN partly results from the difficulty in dissecting out its contributing factors due to the complexity of PHN mechanism. METHODS: Here, to elaborate our understanding of the PHN mechanism and to establish a basis for effective therapeutic strategies, we comprehensively investigated the contributions of multiple factors to PHN severity...
May 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27866180/positive-effects-of-uyakujunkisan-therapy-kampo-medicine-for-postherpetic-neuralgia-with-concomitant-pregabalin-two-case-reports-with-a-literature-review
#14
Toshiaki Kogure, Naoyuki Harada, Kanoko Yamamoto, Takeshi Tatsumi
Context • The hallmark of herpes zoster (HZ) is a painful, blistering rash, but neuropathic pain can persist beyond the clearing of the rash and is diagnosed as postherpetic neuralgia (PHN), a chronic pain syndrome. However, the pain in PHN is often refractory to treatment. Objective • The study investigated the ability of Uyakujunkisan (UJS), or Kampo medicine, a traditional herbal medicine, to treat PHN successfully. Design • The study was observational, with discussion of 2 cases. Setting • The study took place in the Department of Japanese Oriental Medicine at Gunma Central and General Hospital (Maebashi, Gunma, Japan)...
November 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27394022/herpes-zoster
#15
REVIEW
Kenneth Schmader
Herpes zoster causes significant suffering owing to acute and chronic pain or postherpetic neuralgia (PHN). Varicella-zoster virus-induced neuronal destruction and inflammation causes the principal problems of pain, interference with activities of daily living, and reduced quality of life in older adults. The optimal treatment of herpes zoster requires early antiviral therapy and careful pain management. For patients who have PHN, evidence-based pharmacotherapy using topical lidocaine patch, gabapentin, pregabalin, tricyclic antidepressants, or opiates can reduce pain burden...
August 2016: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/27228526/microstructural-abnormalities-in-gray-matter-of-patients-with-postherpetic-neuralgia-a-diffusional-kurtosis-imaging-study
#16
Yi Zhang, Tian Yu, Bangyong Qin, Ying Li, Ganjun Song, Buwei Yu
BACKGROUND: Changes in functional activity and connectivity have been shown in patients experiencing postherpetic neuralgia (PHN) pain. However, PHN-induced structural changes, particularly in the gray matter of which volume and density was widely reported to be altered by other chronic pain, have not been well characterized. OBJECTIVE: In this study, we aimed to detect the difference in the microstructure of gray matter of PHN patients as compared to the healthy controls, and to analyze the correlation between microstructural alterations and clinical features of PHN patients...
2016: Pain Physician
https://www.readbyqxmd.com/read/27224908/methodological-issues-in-conducting-pilot-trials-in-chronic-pain-as-randomized-double-blind-placebo-controlled-studies
#17
RANDOMIZED CONTROLLED TRIAL
Y Tominaga, H Koga, N Uchida, M Wanibe, K Hirose, T Matsumura, A Okamoto, U Richarz, M Etropolski
BACKGROUND: The efficacy of tapentadol extended release (ER) for managing chronic pain has been demonstrated in large-scale, randomized, controlled, phase 3 studies (N=318-1,030) in patients with chronic osteoarthritis (OA) pain, low back pain (LBP), and pain related to diabetic peripheral neuropathy (DPN), which led to registration in many regions, including the United States and Europe. 2 pilot 12-week, randomized, double-blind, placebo-controlled phase 2 studies of tapentadol ER for chronic pain (OA knee pain or LBP, n=91; DPN or peripheral herpetic neuralgia [PHN] pain; n=91) were conducted in Japan...
July 2016: Drug Research
https://www.readbyqxmd.com/read/26879875/post-herpetic-neuralgia-a-review
#18
REVIEW
Graham R Hadley, Julie A Gayle, Juan Ripoll, Mark R Jones, Charles E Argoff, Rachel J Kaye, Alan D Kaye
Post-herpetic neuralgia (PHN) is a chronic neuropathic pain condition that persists 3 months or more following an outbreak of shingles. Shingles, also known as acute herpes zoster, is associated with the reactivation of the dormant varicella zoster virus in an individual who has experienced chicken pox. PHN is associated with persistent and often refractory neuropathic pain. Patients may experience multiple types of pain including a constant deep, aching, or burning pain; a paroxysmal, lancinating pain; hyperalgesia (painful stimuli are more painful than expected); and allodynia (pain associated with typically non-painful stimuli)...
March 2016: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/26761032/ultrasound-guided-nerve-block-with-botulinum-toxin-type-a-for-intractable-neuropathic-pain
#19
Young Eun Moon, Jung Hyun Choi, Hue Jung Park, Ji Hye Park, Ji Hyun Kim
Neuropathic pain includes postherpetic neuralgia (PHN), painful diabetic neuropathy (PDN), and trigeminal neuralgia, and so on. Although various drugs have been tried to treat neuropathic pain, the effectiveness of the drugs sometimes may be limited for chronic intractable neuropathic pain, especially when they cannot be used at an adequate dose, due to undesirable severe side effects and the underlying disease itself. Botulinum toxin type A (BoNT-A) has been known for its analgesic effect in various pain conditions...
January 8, 2016: Toxins
https://www.readbyqxmd.com/read/26482341/anti-cytokine-autoantibodies-in-postherpetic-neuralgia
#20
Ahmad Bayat, Peter D Burbelo, Sarah K Browne, Mark Quinlivan, Bianca Martinez, Steven M Holland, Asokumar Buvanendran, Jeffrey S Kroin, Andrew J Mannes, Judith Breuer, Jeffrey I Cohen, Michael J Iadarola
BACKGROUND: The mechanisms by which varicella zoster virus (VZV) reactivation causes postherpetic neuralgia (PHN), a debilitating chronic pain condition, have not been fully elucidated. Based on previous studies identifying a causative role for anti-cytokine autoantibodies in patients with opportunistic infections, we explored this possibility in PHN. METHODS: Sera from herpes zoster (HZ) patients without and with PHN (N = 115 and 83, respectively) were examined for the presence of autoantibodies against multiple cytokines, and other known autoantigens...
October 20, 2015: Journal of Translational Medicine
keyword
keyword
83872
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"