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https://www.readbyqxmd.com/read/28647863/evaluation-of-cortical-mandibular-bone-in-patients-with-oral-squamous-cell-carcinoma
#1
Gustavo Davi Rabelo, Claudia Coutinho-Camillo, Luiz Paulo Kowalski, Nathalie Portero-Muzy, Jean-Paul Roux, Pascale Chavassieux, Fabio Abreu Alves
OBJECTIVES: The aim of the study was to evaluate the mandible cortical bone changes in patients with oral squamous cell carcinoma (OSCC). PATIENTS AND METHODS: Twenty patients who underwent some mandibular bone removal as part of the treatment of OSCC had bone samples collected in two parts: in the proximity of the tumor (BPT) and in the surgical margin (BEP). Cortical microarchitecture was analyzed trough micro-computed tomography, together with texture analysis, followed by microcrack evaluation in histological sections and gene expression of RANK, RANKL, OPG, and sclerostin by quantitative polymerase chain reaction...
June 24, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28647781/computer-navigation-assisted-surgery-for-musculoskeletal-tumors-a-closer-look-into-the-learning-curve
#2
Kevin Staats, Joannis Panotopoulos, Thomas M Tiefenboeck, Reinhard Windhager, Philipp T Funovics
BACKGROUND: Computer navigation-assisted surgery for musculoskeletal tumors has shown to reduce the risk of intra-lesional margins in resection. Experiences with this method are still limited to smaller case series. METHOD: We reviewed our first experiences in 24 patients in whom computer navigation-assisted surgery had been performed. In 7 of these patients (6 male and 1 female), this has influenced the surgical treatment plan and navigation was used for both tumor resection and reconstruction...
June 24, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28647541/response-tailored-protocol-versus-the-fixed-12weeks-of-dual-sofosbuvir-daclatasvir-treatment-in-egyptian-patients-with-chronic-hepatitis-c-genotype-4-infection-a-randomized-open-label-non-inferiority-trial
#3
Mostafa Yakoot, Alaa M Abdo, Siham Abdel-Rehim, Sherine Helmy
BACKGROUND: The most recent European Association for the Study of the Liver (EASL) 2016 Guidelines on treatment of hepatitis C (HCV), allowed for shortening the course of treatment for some subsets of patients with sofosbuvir/ledipasvir and with grazoprevir/elbasvir based on cutoff baseline HCV RNA values. We hypothesized that it would be prudent to also consider an objectively assuring very rapid, on-treatment, virologic response to therapy at week 2 (vRVR) before taking the decision of shortening the treatment duration...
May 17, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28647388/characterization-of-breast-masses-in-digital-breast-tomosynthesis-and-digital-mammograms-an-observer-performance-study
#4
Heang-Ping Chan, Mark A Helvie, Lubomir Hadjiiski, Deborah O Jeffries, Katherine A Klein, Colleen H Neal, Mitra Noroozian, Chintana Paramagul, Marilyn A Roubidoux
RATIONALE AND OBJECTIVES: This study aimed to compare Breast Imaging Reporting and Data System (BI-RADS) assessment of lesions in two-view digital mammogram (DM) to two-view wide-angle digital breast tomosynthesis (DBT) without DM. MATERIALS AND METHODS: With Institutional Review Board approval and written informed consent, two-view DBTs were acquired from 134 subjects and the corresponding DMs were collected retrospectively. The study included 125 subjects with 61 malignant (size: 3...
June 21, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28647382/il-17a-gene-polymorphism-rs2275913-is-associated-with-the-development-of-asthma-after-bronchiolitis-in-infancy
#5
Annukka Holster, Johanna Teräsjärvi, Eero Lauhkonen, Sari Törmänen, Merja Helminen, Petri Koponen, Matti Korppi, Ville Peltola, Qiushui He, Kirsi Nuolivirta
BACKGROUND: Interleukin-17 (IL-17A) is a mainly pro-inflammatory cytokine, and IL-17 signaling implicates in the development of allergic asthma. The polymorphism rs2275913 in the promoter region of the IL-17A gene has in previous studies been associated with asthma susceptibility. The objective was to evaluate the association between IL-17A rs2275913 (-197G>A) polymorphism and post-bronchiolitis asthma and/or allergic rhinitis in a prospective 11-13 years post-bronchiolitis follow-up...
June 21, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28647136/polypectomy-for-the-complete-endoscopic-resection-of-small-colorectal-polyps
#6
Qisheng Zhang, Peng Gao, Bin Han, Jianhua Xu, Yucui Shen
BACKGROUND AND AIMS: Small colorectal polyps are frequently encountered and may be incompletely removed during colonoscopy. The optimal technique for removal of small colorectal polyps is uncertain. The aim of this study was to compare the incomplete resection rate (IRR) using endoscopic mucosal resection (EMR) or cold snare polypectomy (CSP) for the removal of small adenomatous polyps. METHODS: This was a prospective randomized controlled study from a tertiary referral center...
June 21, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28646907/dimensions-of-social-capital-of-families-with-thalassemia-in-an-indigenous-population-in-tamil-nadu-india-a-qualitative-study
#7
Bharathi Palanisamy, Kalpana Kosalram, Vijayaprasad Gopichandran
BACKGROUND: Studies have shown that social capital is positively associated with health, and the association is context-based. Indigenous populations with poor access to health care largely depend on social capital for their health care needs. This study was conducted to explore the dimensions and types of social capital and its utilization by families with thalassemia for their health and well-being in an indigenous population in Tamil Nadu, India. METHODS: The participants in the study were parents who had children with thalassemia, belonged to an indigenous community in Tamil Nadu, were poor and marginalized, and had poor access to health care...
June 24, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28646644/a-systematic-review-to-uncover-a-universal-protocol-for-accuracy-assessment-of-3-dimensional-virtually-planned-orthognathic-surgery
#8
REVIEW
Ramy M Gaber, Eman Shaheen, Bart Falter, Sebastian Araya, Constantinus Politis, Gwen R J Swennen, Reinhilde Jacobs
PURPOSE: The aim of this study was to systematically review methods used for assessing the accuracy of 3-dimensional virtually planned orthognathic surgery in an attempt to reach an objective assessment protocol that could be universally used. MATERIALS AND METHODS: A systematic review of the currently available literature, published until December 9, 2016, was conducted using PubMed as the primary search engine. We performed secondary searches using the Cochrane Database, clinical trial registries, Google Scholar, and Embase, as well as a bibliography search...
June 1, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28646597/a-contrast-enhanced-ultrasonographic-study-about-the-impact-of-long-term-exercise-training-on-mammary-tumor-vascularization
#9
Ana I Faustino-Rocha, Adelina Gama, Paula A Oliveira, Katrien Vanderperren, Jimmy H Saunders, Maria J Pires, Rita Ferreira, Mário Ginja
OBJECTIVES: This study aimed to evaluate the impact of long-term exercise training on the vascularization of rat mammary tumors. METHODS: Female rats were divided into 4 groups: N-methyl-N-nitrosourea (MNU) treated sedentary, MNU treated exercised, control sedentary, and control exercised. Tumor development was induced in the MNU groups by MNU administration. Exercised groups were trained for 35 weeks. Tumor vascularization was evaluated by pulsed Doppler and contrast-enhanced ultrasonography...
June 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28646388/skin-conductance-reactivity-to-standardized-virtual-reality-combat-scenes-in-veterans-with-ptsd
#10
Mascha van 't Wout, Christopher M Spofford, William S Unger, Elizabeth B Sevin, M Tracie Shea
Interest in virtual reality (VR) as a clinical tool to augment posttraumatic stress (PTSD) treatment has grown substantially in recent years due to advances in VR technology. Moreover, its potential assisted use in the PTSD diagnostic process has been recognized. In this study we examined physiological responding, skin conductance, to a standardized presentation of non-personalized combat-related VR events (e.g. encountering enemy fire; explosions) as compared to non-combat classroom VR events in 19 Veterans with and 24 Veterans without combat-related PTSD who had been deployed to Iraq and Afghanistan...
June 23, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/28646282/surgery-for-pancreatic-ductal-adenocarcinoma
#11
REVIEW
R Vera, L Díez, E Martín Pérez, J C Plaza, A Sanjuanbenito, A Carrato
Surgical resection is the only potentially curative option in the treatment of pancreatic ductal adenocarcinoma. Preoperative radiological imaging allows to rule out the presence of metastases. Three resectability categories are established based on the radiological findings depending on the degree of contact between the tumor and the blood vessels. Histological confirmation of malignancy is only required in cases of borderline or non-resectable tumors, prior to neoadjuvant treatment initiation. Diagnostic laparoscopy is recommended in the presence of large tumors of the body or tail and in borderline tumors to explore the possibility of resection and to apply treatment with curative intent, as well as in those cases with high level of biomarkers to rule out peritoneal involvement...
June 23, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28646172/dacomitinib-a-pan-inhibitor-of-erbb-receptors-suppresses-growth-and-invasive-capacity-of-chemoresistant-ovarian-carcinoma-cells
#12
Majid Momeny, Ghazaleh Zarrinrad, Farima Moghaddaskho, Arash Poursheikhani, Ghazaleh Sankanian, Azam Zaghal, Shahab Mirshahvaladi, Fatemeh Esmaeili, Haniyeh Eyvani, Farinaz Barghi, Zahra Sabourinejad, Zivar Alishahi, Hassan Yousefi, Reza Ghasemi, Leila Dardaei, Davood Bashash, Bahram Chahardouli, Ahmad R Dehpour, Javad Tavakkoly-Bazzaz, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Seyed H Ghaffari
Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy worldwide. Development of chemoresistance and peritoneal dissemination of EOC cells are the major reasons for low survival rate. Targeting signal transduction pathways which promote therapy resistance and metastatic dissemination is the key to successful treatment. Members of the ErbB family of receptors are over-expressed in EOC and play key roles in chemoresistance and invasiveness. Despite this, single-targeted ErbB inhibitors have demonstrated limited activity in chemoresistant EOC...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646122/nintedanib-a-triple-tyrosine-kinase-inhibitor-attenuates-renal-fibrosis-in-chronic-kidney-disease
#13
Feng Liu, Li Wang, Hualin Qi, Jun Wang, Wei Jiang, Yi Wang, Liuqing Xu, Na Liu, Shougang Zhuang
<span style="margin: 0px; color: black; line-height: 200%; font-family: 'Times New Roman',serif; font-size: 12pt;">Nintedanib (BIBF1120) is a triple kinase inhibitor</span><span style="margin: 0px; color: black; line-height: 200%; font-family: 'Times New Roman',serif; font-size: 12pt;"> of </span><span style="margin: 0px; color: black; line-height: 200%; font-family: 'Times New Roman',serif; font-size: 12pt;">platelet derived growth factor receptor (PDGFR), fibroblast growth factor receptors (FGFR)</span><span style="margin: 0px; color: black; line-height: 200%; font-family: 'Times New Roman',serif; font-size: 12pt;">, </span><span style="margin: 0px; color: black; line-height: 200%; font-family: 'Times New Roman',serif; font-size: 12pt;">vascular endothelial growth factor receptor (VEGFR)</span><span style="margin: 0px; color: black; line-height: 200%; font-family: 'Times New Roman',serif; font-size: 12pt;"> and Src family kinase, </span><span style="margin: 0px; color: black; line-height: 200%; font-family: 'Times New Roman',serif; font-size: 12pt;">that has recently been approved by FDA to treat idiopathic pulmonary fibrosis...
June 23, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28645950/variation-in-the-prevalence-of-urinary-catheters-a-profile-of-national-health-service-patients-in-england
#14
David Clifford Shackley, Cameron Whytock, Gareth Parry, Laurence Clarke, Charles Vincent, Abigail Harrison, Amber John, Lloyd Provost, Maxine Power
INTRODUCTION: Harm from catheter-associated urinary tract infections is a common, potentially avoidable, healthcare complication. Variation in catheter prevalence may exist and provide opportunity for reducing harm, yet to date is poorly understood. This study aimed to determine variation in the prevalence of urinary catheters between patient groups, settings, specialities and over time. METHODS: A prospective study (July 2012 to April 2016) of National Health Service (NHS) patients surveyed by healthcare professionals, following a standardised protocol to determine the presence of a urinary catheter and duration of use, on 1 day per month using the NHS Safety Thermometer...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645924/anterior-abdominal-wall-extraosseous-osteosarcoma-occurring-40-years-after-para-aortic-irradiation
#15
Muhammad Furrukh, Asim Qureshi, Nadira Mamoon, Menahil Fatima
Extraskeletal osteosarcomas (OSs) are highly malignant soft tissue tumours associated with a poor prognosis. Only a few records of these rare aggressive neoplasms have been reported in the literature.We describe the case of a 49-year-old man, who presented to our tertiary care centre with a painful isolated lump around the umbilicus. After surgical biopsy, imaging and subsequent pathological analysis, the swelling was diagnosed to be a localised extraskeletal OS. He received previous radiation as treatment for testicular seminoma 40 years ago, which has been in remission ever since...
June 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28645922/management-of-high-grade-dysplasia-of-the-cystic-duct-after-cholecystectomy
#16
Maitham A Moslim, Andrew Tang, Gareth Morris-Stiff
High-grade dysplasia (HGD) of the cystic duct margin without evidence of concurrent malignancy is a rare occurrence. We present a case of a 36-year-old woman who developed gallstone pancreatitis and subsequently underwent a laparoscopic cholecystectomy. On histopathology, she was found to have HGD at the cystic duct margin. Following evaluation, she underwent excision of the cystic duct remnant with no malignancy being present on final pathology. We present this case to discuss the management of cystic duct dysplasia in the absence of gallbladder malignancy...
June 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28645807/prognostic-implication-of-ercc1-protein-expression-in-resected-oropharynx-and-oral-cavity-cancer
#17
Ho Jung An, Heejoon Jo, Chan Kwon Jung, Jin Hyoung Kang, Min Sik Kim, Dong-Il Sun, Kwang Jae Cho, Jung-Hae Cho, Hye Sung Won, Der Sheng Sun, Yoon Ho Ko
BACKGROUND: Excision repair cross complement group 1 (ERCC1) expression is a predictive biomarker for platinum-containing treatment in squamous cell carcinoma of head and neck (SCCHN). However, the prognostic significance after surgical resection is not well understood. METHODS: Oropharynx (n=143) or oral cavity (n=61) SCCHN patients undergoing surgery were included. ERCC1 protein expression and HPV status were assessed by ERCC1 and p16 immunohistochemistry. RESULTS: The ERCC1, over-expressed in 66...
May 31, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28645606/presence-of-a-malignant-tumor-as-a-novel-predictive-factor-for-repeated-recurrences-of-chronic-subdural-hematoma
#18
Yusuke S Hori, Mizuho Aoi, Kazunori Oda, Toru Fukuhara
BACKGROUND: Various risk factors for recurrence of chronic subdural hematomas (CSDHs) have been reported, including alcohol addiction and diabetes mellitus. However, the significance of malignant tumors with respect to CSDH recurrence remains unclear. METHODS: We retrospectively evaluated 281 patients with a first-time CSDH from 2006 to 2016. The difference in the recurrence rate within 100 days postoperatively was compared between patients with a past or present extracranial malignant tumor and those with neither a past nor present extracranial malignant tumor at presentation...
June 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28645309/herpes-simplex-virus-1-infects-the-olfactory-bulb-shortly-following-ocular-infection-and-exhibits-a-long-term-inflammatory-profile-in-the-form-of-effector-and-hsv-1-specific-t-cells
#19
Chandra M Menendez, Daniel J J Carr
BACKGROUND: Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) following ocular infection are unresolved. We evaluated early viral dissemination pathways following ocular infection that involve trafficking to the olfactory bulb (OB). Additionally, we have characterized the capacity of HSV-1 to establish latency within OB tissue and profiled the local T lymphocyte response over the course of the acute infection into latency...
June 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28645235/external-validity-of-the-new-york-university-caregiver-intervention-key-caregiver-outcomes-across-multiple-demonstration-projects
#20
Elizabeth B Fauth, Mark A Jackson, Donna K Walberg, Nancy E Lee, Leisa R Easom, Gayle Alston, Angel Ramos, Kristen Felten, Asenath LaRue, Mary Mittelman
PURPOSE OF THE STUDY: The Administration on Aging funded six New York University Caregiver Intervention (NYUCI) demonstration projects, a counseling/support intervention targeting dementia caregivers and families. Three sites (Georgia, Utah, Wisconsin) pooled data to inform external validity in nonresearch settings. This study (a) assesses collective changes over time, and (b) compares outcomes across sites on caregiver burden, depressive symptoms, satisfaction with social support, family conflict, and quality of life...
June 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
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