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https://www.readbyqxmd.com/read/28523315/sinonasal-non-hodgkin-s-malignant-lymphoma-review-of-a-clinical-case
#1
Vlad Andrei Budu, Mihail Tuşaliu, Tatiana Decuseară, Ioan Alexandru Bulescu, Cristiana Gabriela Popp, Alexandru Panfiloiu, Andreea Nicoleta Costache, Iuliana Lupu, Carmen Aurelia Mogoantă
Malignant lymphomas represent one of the most important problems of modern medicine, with a constant increase in the last decades, becoming the most frequent tumor among young people. Sinonasal localization is a particular site of malignant lymphomas, representing the second most frequent among ear, nose and throat (ENT) tumors. In this paper, authors present the clinical, diagnostic and therapeutic aspects of a malignant sinonasal lymphoma, which despite an aggressive histological subtype and important regional extension had a favorable clinical outcome...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28499777/lack-of-efficacy-of-symptoms-and-medical-history-in-distinguishing-the-degree-of-eosinophilia-in-nasal-polyps
#2
John W Steinke, Anna R Smith, Delaney J Carpenter, James T Patrie, Spencer C Payne, Larry Borish
BACKGROUND: Distinguishing eosinophilic nasal polyps (NP) from noneosinophilic NP will impact prognosis and therapeutic responsiveness. OBJECTIVE: To investigate the ability of clinical history and biomarkers to distinguish these conditions. METHODS: A total of 74 consecutive patients undergoing surgery for NP were enrolled. Clinical presentations were evaluated using the 22-item sinonasal outcome test (SNOT-22). Biomarkers included absolute eosinophil count, IgE, and extent of tissue hyperplasia on sinus computed tomography scan...
May 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28498627/a-uk-community-based-survey-on-the-prevalence-of-rhinosinusitis
#3
Amtul S Sami, Glenis K Scadding, Peter Howarth
OBJECTIVES: There is limited information about the prevalence of rhinosinusitis in the UK community. This study aims to identify its prevalence and investigate any association with demographic variables. The secondary aims are to determine the degree of impairment, impact on quality of life and any costs incurred by patients. DESIGN: We used a modified version (MSNOT-20) of a quality of life instrument; the sinonasal outcome test -20 (SNOT-20), in a small and successful pilot project...
May 12, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28497509/characteristics-and-prognosis-of-glomangiopericytomas-a-systematic-review
#4
REVIEW
Eun Su Park, Jiyoung Kim, Sun-Young Jun
BACKGROUND: Glomangiopericytoma belongs to the category of borderline/low-malignant-potential tumors of the sinonasal tract, but no studies about prognosis have been reported. METHODS: To define the characteristics of glomangiopericytoma and to identify its prognostic factors, a systematic review was performed. A total of 337 cases of glomangiopericytomas were analyzed. RESULTS: Patients with glomangiopericytoma demonstrating resection margin involvement and receiving radiotherapy/chemotherapy had a significantly worse disease-free survival time (P =  ...
May 12, 2017: Head & Neck
https://www.readbyqxmd.com/read/28496329/minimally-invasive-endoscopic-resection-for-the-treatment-of-sinonasal-malignancy-the-outcomes-and-risk-factors-for-recurrence
#5
Ning He, Xiaohong Chen, Luo Zhang, Xuejun Chen, Zhigang Huang, Qi Zhong, Hongzhi Ma, Ling Feng, Lizhen Hou, Jugao Fang
PURPOSE: The role of minimally invasive endoscopic resection (MIER) in the treatment of sinonasal malignancy is controversial. Herein, we performed a retrospective review of a large case series of sinonasal malignancy patients treated with MIER aimed at evaluating the outcomes and identifying the risk factors for recurrence. METHODS: Patients with sinonasal malignancy who underwent MIER from March 2000 to May 2015 were enrolled, and their clinical data were collected...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28494786/compositionally-and-functionally-distinct-sinus-microbiota-in-chronic-rhinosinusitis-patients-have-immunological-and-clinically-divergent-consequences
#6
Emily K Cope, Andrew N Goldberg, Steven D Pletcher, Susan V Lynch
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by persistent sinonasal inflammation and sinus microbiome dysbiosis. The basis of this heterogeneity is poorly understood. We sought to address the hypothesis that a limited number of compositionally distinct pathogenic bacterial microbiota exist in CRS patients and invoke discrete immune responses and clinical phenotypes in CRS patients. RESULTS: Sinus brushings from patients with CRS (n = 59) and healthy individuals (n = 10) collected during endoscopic sinus surgery were analyzed using 16S rRNA gene sequencing, predicted metagenomics, and RNA profiling of the mucosal immune response...
May 12, 2017: Microbiome
https://www.readbyqxmd.com/read/28494469/mutation-status-among-patients-with-sinonasal-mucosal-melanoma-and-its-impact-on-survival
#7
Moran Amit, Samantha Tam, Ahmed S Abdelmeguid, Dianna B Roberts, Yoko Takahashi, Shaan M Raza, Shirley Y Su, Michael E Kupferman, Franco DeMonte, Ehab Y Hanna
BACKGROUND: Sinonasal mucosal melanoma (SNMM) comprises <1% of all melanomas and lacks well-characterised molecular markers. Our aim was to determine the frequencies of common mutations and examine their utility as molecular markers in a large series of primary SNMMs. METHODS: SNMM patients seen at our institution from August 1991 through July 2016 were identified. Genomic DNA was extracted from 66 formalin-fixed paraffin-embedded tumours and screened for mutations by direct sequencing...
May 11, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28494137/acute-radiology-rarely-confirms-sinus-disease-in-suspected-recurrent-acute-rhinosinusitis
#8
Henry P Barham, Alexander S Zhang, Jenna M Christensen, Raymond Sacks, Richard J Harvey
BACKGROUND: Episodic or recurrent sinonasal symptoms are often suspected as "sinus" in origin. With normal sinus radiology between events, the diagnosis of recurrent acute rhinosinusitis (RecARS) is made. However, other conditions can produce episodic symptoms. In this study we analyze acutely performed computed tomography (CT) in a population with suspected or self-diagnosed "sinus" disease. METHODS: Patients referred to a tertiary clinic for suspected RecARS were assessed...
May 11, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28493366/frequent-idh2-r172-mutations-in-undifferentiated-and-poorly-differentiated-sinonasal-carcinomas
#9
Snjezana Dogan, Deborah J Chute, Bin Xu, Ryan N Ptashkin, Raghu Chandramohan, Jacklyn Casanova-Murphy, Khedoudja Nafa, Justin A Bishop, Simion I Chiosea, Edward B Stelow, Ian Ganly, David G Pfister, Nora Katabi, Ronald A Ghossein, Michael F Berger
Sinonasal undifferentiated carcinoma (SNUC) is a high-grade malignancy with limited treatment options and poor outcome. A morphologic spectrum of 47 sinonasal tumors including 17 (36.2%) SNUCs were analyzed at genomic level. Thirty carcinomas (Cohort 1) were subjected to a hybridization exon-capture next-generation sequencing assay (MSK-IMPACT(TM) ) to interrogate somatic variants in 279 or 410 cancer-related genes. Seventeen sinonasal tumors (Cohort 2) were examined only for presence of IDH1/2 exon 4 mutations by Sanger sequencing...
May 11, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28492612/a-prospective-randomized-clinical-study-comparing-drug-eluting-stent-therapy-and-intranasal-corticoid-steroid-therapy-in-the-treatment-of-patients-with-chronic-rhinosinusitis
#10
R Taulu, A J Bizaki, J Numminen, M Rautiainen
OBJECTIVES: To conduct the first prospective, randomized controlled clinical trial comparing the efficacy of a drug-eluting stent (DES) (the Relieva StratusTM MicroFlow Spacer) and topical intranasal corticosteroid therapy in patients with chronic rhinosinusitis (CRS). METHODS: Sixty-three adult patients with ethmoiditis were randomized into either the DES group (n=34) or nasal spray group (n=29). The main outcome variable was the Sinonasal Outcome Test 22, Visual Analogue Scale, nasal endoscopy, rhinometric measurements were performed at the beginning of the study, after three months and six months of follow-up...
May 10, 2017: Rhinology
https://www.readbyqxmd.com/read/28492611/the-effect-of-topical-treatments-for-crs-on-the-sinonasal-epithelial-barrier
#11
M Ramezanpour, A Rayan, J L P Smith, S Vreugde
BACKGROUND: Several topical treatments are used in the management of Chronic Rhinosinusitis (CRS), some of which the safety and efficacy has yet to be determined. The purpose of this study was to investigate the effect of commonly used topical treatments on the sinonasal epithelial barrier. METHODS: Normal saline (0.9% Sodium Chloride), hypertonic saline (3% Sodium Chloride), FESS Sinu-Cleanse Hypertonic, FLO Sinus Care and Budesonide 1 mg/ 2 ml were applied to the apical side of air-liquid interface (ALI) cultures of primary human nasal epithelial cells (HNECs) from CRS patients (n=3) and non-CRS controls (n=3) for 24 hours...
May 10, 2017: Rhinology
https://www.readbyqxmd.com/read/28492608/sinonasal-symptom-related-sleep-disorders-before-and-after-surgery-for-nasal-polyposis
#12
D T Nguyen, F Arous, P Gallet, M Felix-Ravelo, P L Nguyen-Thi, C Rumeau, R Jankowski
BACKGROUND: Patients with nasal polyposis (NP) complain of several sinonasal symptoms that impact their sleep and quality of life. However, data on sleep disorders related to NP symptoms, before and after surgery, is poor. The aim of the present study was to analyze sleep complaints related to each NP symptom, before and after surgery, using the Dynachron questionnaire. METHODOLOGY: 63 patients operated for NP were included in this prospective study. They filled the DyNaChron questionnaire one day before surgery (V0), 6 weeks (V1) and 7 months (V2) after surgery...
May 10, 2017: Rhinology
https://www.readbyqxmd.com/read/28492494/nasal-irrigation-an-imprecisely-defined-medical-procedure
#13
REVIEW
Nicola Principi, Susanna Esposito
Nasal irrigation (NI) is an old practice of upper respiratory tract care that likely originated in the Ayurvedic medical tradition. It is used alone or in association with other therapies in several conditions-including chronic rhinosinusitis and allergic rhinitis-and to treat and prevent upper respiratory tract infections, especially in children. However, despite it being largely prescribed in everyday clinical practice, NI is not included or is only briefly mentioned by experts in the guidelines for treatment of upper respiratory tract diseases...
May 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28491178/ossifying-fibroma-an-uncommon-differential-diagnosis-for-t2-hypointense-sinonasal-masses
#14
Andrea Carolina Inacio Salina, Pedro Mansueto Melo de Souza, Camila Maria da Costa Gadelha, Lindenberg Barbosa Aguiar, José Daniel Vieira de Castro, André Rodrigues Façanha Barreto
Ossifying fibroma is a benign fibro-osseous lesion that occurs most commonly in the mandible of female patients. In rare cases, it affects the nasal cavity. The magnetic resonance imaging features may vary depending on the amount of fibrous and bony tissue in its composition. In these tumors, T2-hypointensity is a feature described in the peripheral ossified areas of the lesion, but it may present diffusely, especially when the degree of ossification is extensive. In this scenario, this particular characteristic on T2-weighted imaging is superimposable to the commonly described appearance of other lesions, such as non-Hodgkin's lymphoma, melanoma, and other sinonasal neoplasms with high cellularity and high nucleocytoplasmic ratio...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28490410/recurrence-of-sinonasal-inverted-papilloma-following-surgical-approach-a-meta-analysis
#15
Ronald G Amedee
No abstract text is available yet for this article.
May 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28490408/endoscopic-resection-of-sinonasal-mucosal-melanoma-has-comparable-outcomes-to-open-approaches
#16
Amar Miglani, Samir H Patel, Heidi E Kosiorek, Michael L Hinni, Richard E Hayden, Devyani Lal
BACKGROUND: Endoscopic endonasal resection (EER) of sinonasal mucosal melanoma (SMM) is a newer surgical alternative to traditional external and/or open resection (OR). Studies on long-term outcomes are necessary to validate EER for this aggressive sinonasal malignancy. OBJECTIVE: To compare outcomes of EER versus OR in SMM. METHODS: A case series of patients who underwent surgical resection of SMM at a tertiary-care institution (2000-2015) was studied retrospectively...
May 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28489242/large-pediatric-maxillary-dentigerous-cysts-presenting-with-sinonasal-and-orbital-symptoms-a-case-series
#17
Shakil Ahmed Nagori, Anson Jose, Ongkila Bhutia, Ajoy Roychoudhury
Dentigerous cysts are benign odontogenic cysts associated with the crowns of unerupted, embedded, or impacted teeth. Most of them are associated with mandibular third molars, followed by maxillary third molars and canines. They are usually asymptomatic, and rarely do they grow extensively and compress the adjacent anatomic structures. We report 5 cases of extensive maxillary dentigerous cysts presenting with sinonasal and orbital symptoms. A literature review for similar presentations of dentigerous cysts has demonstrated 21 cases...
April 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28485293/the-rapid-change-in-sinonasal-inverted-papilloma-incidence-the-epidemiological-analysis
#18
Roland Zydroń, Grażyna Greczka, Małgorzata Wierzbicka
In recent years, the incidence of sinonasal inverted papilloma (IP) in a stable population has increased significantly. The aim of the study was to analyze the occurrence of IP between the years 2002-2012 in relation to epidemiological factors in an unalterable area. Moreover, we wanted to start a discussion about the difficulties in determining the inci¬dence of benign lesions that are not included in registers. This retrospective study included a group of 69 patients who were treated in the Department of Otolaryngology, ENT Oncology, Poznań University of Medical Sciences...
February 28, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28485287/clinical-outcomes-of-treatment-of-sinonasal-inverted-papillomas-ips-depending-on-the-surgical-technique-and-learning-curve
#19
Roland Zydroń, Małgorzata Wierzbicka, Grażyna Greczka
INTRODUCTION: Sinonasal inverted papillomas (IPs) are a major challenge for ENT specialists. In the last decades, the number of endoscopic procedures has increased, while the percentage of external or double approach procedures has decreased. The aim of this study was to evaluate long-term IP treatment outcomes according to the applied surgical method. MATERIAL AND METHODS: the retrospective study included 69 patients (28 women and 41 men) treated during 2002-2012 in the Department of Otolaryngology and Laryngological Oncology of Poznań University of Medical Sciences...
November 20, 2016: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28485285/endoscopic-surgical-management-of-sinonasal-inverted-papilloma-extending-to-frontal-sinuses
#20
Yukiko Takahashi, Fumi Shoji, Yukio Katori, Hiroshi Hidaka, Naoya Noguchi, Yasuhiro Abe, Risako Kakuta Kakuta, Takahiro Suzuki, Yusuke Suzuki, Nobuo Ohta, Seiji Kakehata, Yoshitaka Okamoto
OBJECTIVE: Sinonasal inverted papilloma has been traditionally managed with external surgical approaches. Advances in imaging guidance systems, surgical instrumentation, and intraoperative multi-visualization have led to a gradual shift from external approaches to endoscopic surgery. However, for anatomical and technical reasons, endoscopic surgery of sinonasal inverted papilloma extending to the frontal sinuses is still challenging. Here, we present our experience in endoscopic surgical management of sinonasal inverted papilloma extending to one or both frontal sinuses...
November 10, 2016: Otolaryngologia Polska
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