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https://www.readbyqxmd.com/read/28207194/clinical-outcomes-of-sinonasal-squamous-cell-carcinomas-based-on-tumor-etiology
#1
Carol H Yan, Jason G Newman, David W Kennedy, James N Palmer, Nithin D Adappa
BACKGROUND: Squamous cell carcinoma (SCC) of the sinonasal cavity is a rare entity that arises as either de-novo tumors or from inverted papillomas (IPs). In this study we evaluate and compare oncologic outcomes of sinonasal SCCs based on their etiology and treatment strategy. METHODS: This investigation was a single-center, retrospective review comparing de-novo SCCs (n = 28) and those associated with IPs (n = 38) resected during the period from 2000 to 2015. Demographic and tumor data, surgical approach, recurrence, and clinical outcomes were analyzed...
February 16, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28205501/transseptal-access-with-crossing-multiple-incisions-for-improved-pedicle-control-and-septum-preservation-how-i-do-it
#2
K Omura, D Asaka, J Nayak, Y Tanaka
INTRODUCTION: Recently, the surgical management of nasal tumors has been greatly influenced by advanced endoscopic techniques. To achieve complete endoscopic resection of large obstructing nasal tumors, a sufficient corridor for adequate exposure is also required. In the Japanese language, TACMI means "master expert," and herein we describe an endoscopic technique with novel elements that we term transseptal access with crossing multiple incisions (TACMI). This approach enables a direct transseptal approach to the pedicle through tumor transposition while allowing complete septal reconstruction and stability...
February 15, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28203170/primary-ewing-s-sarcoma-of-the-sinonasal-tract-a-case-report
#3
Tomoharu Suzuki, Ryuji Yasumatsu, Torahiko Nakashima, Shuji Arita, Hidetaka Yamamoto, Takashi Nakagawa
A 23-year-old male presented with a 3-month history of left purulent rhinorrhea, progressive nasal obstruction, and intermittent epistaxis. A fiberoptic examination revealed a large vascular polypoid mass completely filling the left nasal cavity. CT and MRI scans showed a large hypervascular mass involving the left nasal airway, maxillary antrum, and the anterior ethmoid cells. There was no bony erosion or contiguous spread, and the remaining sinuses, orbit, and cranial fossa were uninvolved. The patient underwent complete removal of the mass via an external lateral rhinotomy approach...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28199369/nasal-nitric-oxide-in-unilateral-sinus-disease
#4
Chia-Hsiang Fu, Hsiao-Jung Tseng, Chi-Che Huang, Po-Hung Chang, Yi-Wei Chen, Ta-Jen Lee
Unilateral sinus disease (USD) can sometimes be difficult to accurately diagnose before surgery. The application of nasal nitric oxide (nNO) for USD diagnosis and its surgical outcome in USD has not been reported in the literature. We prospectively enrolled sixty-six USD patients who underwent endoscopic sinus surgery for fungal rhinosinusitis (n = 19), chronic rhinosinusitis (CRS) without nasal polyps (n = 13), CRS with nasal polyps (n = 12) and sinonasal mass lesions (n = 22). nNO levels were measured preoperatively and at three and six months postoperatively...
2017: PloS One
https://www.readbyqxmd.com/read/28199345/impact-of-chronic-rhinosinusitis-on-severe-asthma-patients
#5
Ta-Jen Lee, Chia-Hsiang Fu, Chun-Hua Wang, Chi-Che Huang, Chien-Chia Huang, Po-Hung Chang, Yi-Wei Chen, Chia-Chen Wu, Ching-Lung Wu, Han-Pin Kuo
Coexistence of chronic rhinosinusitis (CRS) with asthma appears to impair asthma control. Type-2 innate lymphoid cells (ILC2s) respond to the cytokines of thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33, thus contributing to airway diseases such as CRS and asthma. We investigate whether the augmented Th2-cytokines in CRS might be related to sinonasal tract ILC2s corresponding to enhanced IL-25, IL-33 and TSLP release in severe asthmatics, and be involved in asthma control. Twenty-eight asthmatics (12 non-severe and 16 severe) with CRS receiving nasal surgery were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28197925/giant-prolactinoma-presenting-as-a-base-of-skull-tumor-with-nasopharyngeal-extension-a-potential-diagnostic-pitfall-in-neuroendocrine-lesions-of-the-base-of-skull
#6
Amy Prawira, Dorothy Lazinski, Lillian L Siu, Bayardo Perez-Ordonez
Pituitary adenomas presenting in uncommon anatomical locations are commonly misdiagnosed. Dramatic clinical presentation with hemorrhage and infarction, along with a lack of endocrine symptoms may further confound the diagnosis in some patients as illustrated in one of our two previously reported cases of non-small cell neuroendocrine carcinoma of the sinonasal tract and nasopharynx. This report presents the clinical progress of case number 2, which has a revised diagnosis of giant lactotroph pituitary adenoma...
February 14, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28194802/safe-treatment-of-ethmoid-sinusitis-utilizing-minimally-invasive-ethmoid-punch-sinusotomy-eps-in-chronic-rhinosinusitis-without-polyposis-crssnp-patients
#7
Nathalia Velasquez, Andrew Thamboo, Waleed M Abuzeid, Jayakar V Nayak
OBJECTIVES/HYPOTHESIS: Current rhinologic practice is devoid of minimally invasive procedures dedicated to the treatment of ethmoid sinusitis to improve ventilation and topical drug delivery. We have recently described a handheld spiral punch to create minimally invasive ethmoid punch sinusotomy (EPS) sites into the ethmoid bulla and basal lamella, which significantly increased irrigant access to the ethmoid sinuses in cadaver models. Here, we conducted a clinical feasibility study to determine the initial safety evaluation of EPS in chronic rhinosinusitis without polyposis (CRSsNP) patients with active ethmoid disease...
February 14, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28185972/optimizing-sellar-reconstruction-after-pituitary-surgery-with-free-mucosal-graft-results-in-the-first-50-consecutive-patients
#8
Maria Peris-Celda, Mark Chaskes, Daniel D Lee, Tyler J Kenning, Carlos D Pinheiro-Neto
BACKGROUND: Postoperative CSF leak after endoscopic pituitary surgery ranges from 1.9-10% in different series. Vascularized flaps have reduced the incidence of leak, however it carries nasal morbidity. This paper presents a technique for sellar reconstruction with free mucosal graft from the nasal cavity floor including inferior meatus mucosa. This technique aims to standardize sellar reconstruction without the use of the nasoseptal flap and keeping the advantage of mucosal coverage of the defect in all cases...
February 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28183679/glomangiopericytoma-hemangiopericytoma-of-the-maxillary-sinus-and-sinonasal-tract
#9
Samaher Al Saad, Razan Al Hadlaq, Nabil Al-Zaher
No abstract text is available yet for this article.
February 1, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28176137/smarca4-deficient-sinonasal-carcinoma
#10
Abbas Agaimy, Wilko Weichert
The term "sinonasal undifferentiated carcinoma (SNUC)" has been coined in 1986 for a highly aggressive sinonasal tract epithelial neoplasm showing distinctive morphology, but lacking any specific line of differentiation. Recent developments resulted in a dynamic splitting of new entities traditionally included in the spectrum of SNUC. Sinonasal NUT-midline carcinoma, adamantinoma-like Ewing family tumors and most recently, SMARCB1(INI1)-deficient sinonasal carcinoma are the main entities defined by specific genetic aberrations...
February 7, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28173955/nasopharyngeal-adenocarcinoma-a-population-based-analysis
#11
Edward C Kuan, Jose E Alonso, Armin Arshi, Maie A St John
OBJECTIVES/HYPOTHESIS: To describe the incidence and determinants of survival of patients with nasopharyngeal adenocarcinoma between the years of 1973 to 2012 using the Surveillance, Epidemiology, and End Result (SEER) database. STUDY DESIGN: Retrospective cohort study using a national database. METHODS: The SEER registry was utilized to calculate survival trends for patients with nasopharyngeal adenocarcinoma between 1973 and 2012. Patient data was then analyzed with respect to histopathology, age, sex, race, stage, grade, and treatment modalities (surgery and radiation therapy)...
January 31, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28168398/olfactory-neuroblastoma-with-divergent-differentiation-an-unusual-histologic-finding-in-a-rare-tumor
#12
Charles Meyer, Erin R S Hamersley, Rodolfo E Manosalva, Kevin Torske, Nicole McIntyre, Allen Mitchell
Olfactory neuroblastoma (ONB) is a rare malignant neoplasm of the sinonasal tract that arises from olfactory epithelium. There have been reports, mainly in tumors treated with chemoradiation or with distant metastases, describing focal histologic changes of divergent cell populations within archetypal ONB. Only three cases have been reported of ONB coexisting with non-neuroendocrine tumors. We describe our experience with a 35-year-old male with a nasal cavity mass extending into the anterior cranial fossa...
February 6, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28165837/endoscopic-dacryocystorhinostomy-following-head-and-neck-radiation-therapy
#13
Adam R Sweeney, Greg E Davis, Shu-Hong Chang, Arash Jian-Amadi
This article determines the efficacy of endoscopic dacryocystorhinostomy (endoDCR) in patients who have undergone adjuvant external beam radiation therapy (XRT) following head and neck cancer resection. A retrospective chart review was performed on all patients who underwent endoDCR between 2006 and 2014 at a tertiary referral center. Cases were reviewed and selected for the following inclusion criteria: history of adjuvant sinonasal XRT following head and neck cancer resection, preoperative probing and irrigation demonstrating nasolacrimal duct obstruction (NLDO), postoperative probing and irrigation following silicone tube extubation...
February 6, 2017: Orbit
https://www.readbyqxmd.com/read/28162241/transfacial-and-craniofacial-approaches-for-resection-of-sinonasal-and-ventral-skull-base-malignancies
#14
REVIEW
Elizabeth L Perkins, Bryan M Brandon, Satyan B Sreenath, Dipan D Desai, Brian D Thorp, Charles S Ebert, Adam M Zanation
Malignancies of the paranasal sinuses and ventral skull base present unique challenges to physicians. A transfacial or craniofacial approach allows for wide, possibly en bloc resection and is ideal for tumors that involve surrounding soft tissue, the palate, the orbit, anterolateral frontal sinus, and lateral dura. Transfacial approaches include a lateral rhinotomy often combined with a medial, subtotal, or total maxillectomy. Reconstruction is most commonly performed with a pericranial flap to separate the intranasal and intracranial compartments...
February 2, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28162240/endoscopic-resection-of-sinonasal-and-ventral-skull-base-malignancies
#15
REVIEW
Ghassan Alokby, Roy R Casiano
The transnasal endoscopic resection of ventral skull base lesions represents a safe and effective method for the surgical management of sinonasal and ventral skull base malignancies in carefully selected cases. The goal of surgery is complete removal of all tumor with negative resection margins while maintaining the key oncological principles. Careful selection of cases along with the presence of an experienced surgeon and a fully involved multidisciplinary skull base team trained in the management of ventral skull base neoplasm are essential for excellent outcomes...
February 2, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28160998/overview-of-sinonasal-and-ventral-skull-base-malignancy-management
#16
REVIEW
Peter F Svider, Michael Setzen, Soly Baredes, James K Liu, Jean Anderson Eloy
Significant technological advances have fostered a movement toward minimally invasive surgical interventions for the management of ventral skull base malignancies. The care of patients with these lesions ideally involves an interdisciplinary skull base team that includes otolaryngologists, neurologic surgeons, radiation oncologists, and medical oncologists. This overview describes considerations essential for diagnosis, prognosis, and preoperative evaluation. Furthermore, surgical nuances, strategies for skull base reconstruction, and nonsurgical options are briefly discussed...
February 1, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28160997/the-role-of-chemotherapy-in-the-management-of-sinonasal-and-ventral-skull-base-malignancies
#17
REVIEW
George A Scangas, Jean Anderson Eloy, Derrick T Lin
In most cases of advanced sinonasal and ventral skull base cancer, a multimodal treatment approach provides the best chance for improved outcomes. Depending on the tumor type and extent of disease, systemic chemotherapy has been shown to play an important role in neoadjuvant, concomitant, and adjuvant settings. The lack of randomized trials continues to limit its indications. Further high-quality studies are needed to understand ideal chemotherapeutic regimens and their role and sequential timing in sinonasal and ventral skull base cancer...
February 1, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28160996/survival-morbidity-and-quality-of-life-outcomes-for-sinonasal-and-ventral-skull-base-malignancies
#18
REVIEW
Suat Kilic, Sarah S Kilic, Soly Baredes, James K Liu, Jean Anderson Eloy
Sinonasal and ventral skull base malignancies are a rare, heterogeneous group of cancers. Although prognosis usually depends on many factors, long-term survival rates remain low despite recent advances. Population-based databases are powerful resources for studying survival outcomes. However, institutional retrospective chart-review studies have been able to provide more insight on recurrence patterns, morbidity, and quality-of-life metrics, as well as more details of the treatment information that may affect outcomes...
February 1, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28160995/the-making-of-a-skull-base-team-and-the-value-of-multidisciplinary-approach-in-the-management-of-sinonasal-and-ventral-skull-base-malignancies
#19
REVIEW
Carl H Snyderman, Eric W Wang, Juan C Fernandez-Miranda, Paul A Gardner
The management of sinonasal and ventral skull base malignancies is best performed by a team. Although the composition of the team may vary, it is important to have multidisciplinary representation. There are multiple obstacles, both individual and institutional, that must be overcome to develop a highly functioning team. Adequate training is an important part of team-building and can be fostered with surgical telementoring. A quality improvement program should be incorporated into the activities of a skull base team...
February 1, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28160430/patient-reported-control-of-chronic-rhinosinusitis-symptoms-is-positively-associated-with-general-health-related-quality-of-life
#20
Stacey T Gray, Lloyd P Hoehle, Katie M Phillips, David S Caradonna, Ahmad R Sedaghat
OBJECTIVE: In chronic rhinosinusitis (CRS), although patient-reported severity of sinonasal symptoms is significantly associated with diminishment of patients' general health-related quality of life (QOL), it remains unclear whether patient-perceived control of CRS symptomatology is associated with patients' QOL. In this study, we sought to determine the association between patient-perceived control of CRS symptomatology and QOL. DESIGN: Prospective cross-sectional study...
February 3, 2017: Clinical Otolaryngology
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