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https://www.readbyqxmd.com/read/29774747/hypertonic-saline-versus-isotonic-saline-nasal-irrigation-systematic-review-and-meta-analysis
#1
Dichapong Kanjanawasee, Kachorn Seresirikachorn, Wirach Chitsuthipakorn, Kornkiat Snidvongs
Background Saline nasal lavage is one of the treatments of sinonasal diseases. Evidence from basic research favors hypertonic saline (HS) over isotonic saline (IS) for mucociliary clearance, but evidence from clinical studies is controversial. Conversely, HS may carry greater side effects. Objective To compare the effects of HS and IS nasal irrigation in treating sinonasal diseases. Methods Systematic search with Ovid MEDLINE, Scopus, PubMed, Google Scholar, and Manual additional sources was conducted. Randomized controlled trials comparing HS with IS nasal irrigation in treating any sinonasal diseases, including rhinitis and rhinosinusitis, were included...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29774383/acute-invasive-fungal-rhinosinusitis-mr-imaging-features-and-their-impact-on-prognosis
#2
Ye Ra Choi, Ji-Hoon Kim, Hye Sook Min, Jae-Kyung Won, Hyun Jik Kim, Roh-Eul Yoo, Koung Mi Kang, Sun-Won Park, Tae Jin Yun, Seung Hong Choi, Chul-Ho Sohn, Jung Hyo Rhim, Soo Chin Kim, Jae Wook Ryu, Dong Gyu Na
PURPOSE: Acute invasive fungal rhinosinusitis (AIFRS) is a life-threatening disease that is difficult to diagnose. Its overall imaging features have not been evaluated and the prognostic impact is unclear. The purpose of our study was to present MR imaging features and their impact on prognosis of AIFRS. METHODS: MR images and clinical records of 23 patients with AIFRS were retrospectively evaluated to identify the imaging features and to determine the factors affecting patients' survival...
May 17, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29773436/non-sinonasal-isolated-facio-orbital-mucormycosis-a-case-report
#3
S K Swain, M C Sahu, A Banerjee
Mucormycosis is a rare clinical entity, often affect immunocompromised patients. It is an emergency situation and has poor prognosis. Prompt diagnosis with tissue biopsy, local control of the disease by aggressive surgical debridement and appropriate systemic antifungal treatment improve the prognosis and survival of the patients. Treatment of mucormycosis needs antifungal agents such as Amphotericin B and wide surgical debridement. Early diagnosis and treatment is often needed for survival of the patients...
May 14, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29767533/sirt1-controls-poly-i-c-dependent-mmp9-activation-in-primary-human-nasal-epithelial-cells
#4
Masanobu Suzuki, Mahnaz Ramezanpour, Clare Cooksley, Jian Li, Yuji Nakamaru, Akihiro Homma, Alkis Psaltis, Peter-John Wormald, Sarah Vreugde
BACKGROUND: Matrix metalloproteinase 9 (MMP9) is thought to be involved in the etiopathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) and cleaves collagen IV causing hyperpermeability of the basement membrane within mucosal tissue. It is known that MMP9 expression is negatively affected by sirtuin-1 (SIRT-1) in human monocytotic cells, retinal endothelial cells and epithelial carcinoma cells. However, it is unknown which factors affect MMP9 expression and activity in human nasal epithelial cells (HNECs)...
May 16, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29765826/rates-and-locations-of-regional-metastases-in-sinonasal-malignancies-the-mayo-clinic-experience
#5
Brandon W Peck, Kathryn M Van Abel, Eric J Moore, Daniel L Price
Objectives  The objective of this study was to identify factors that may influence the rate and location of regional metastasis in sinonasal malignancies (SNMs). Design  This is a retrospective review. Setting  This study was set at the single-institution tertiary referral center. Participants  A total of 299 patients were treated for SNMs from 1994 to 2014. Main Outcome Measures  The main outcome measures were incidence and distribution of regional metastases. Results  Several histologic subtypes were treated, with squamous cell carcinoma (28...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29764790/a-case-of-inverted-papilloma-of-the-mastoid-cavity-after-cholesteatoma-surgery
#6
Goh Eui-Kyung, Cho Ilyoung, Oh Se-Joon, Choi Sung-Won, Kim Young-Keum
An inverted papilloma is a benign neoplasm that occurs exclusively in the sinonasal cavity; an inverted papilloma involving the mastoid cavity is extremely rare. We present the case of a patient with an inverted papilloma of the mastoid cavity secondary to cholesteatoma surgery. No case that occurred after acquired cholesteatoma has been reported in literature. A 39-year-old female who was diagnosed with cholesteatoma was treated with a modified radical mastoidectomy in 1988. After recurrence, the patient underwent a canal wall down mastoidectomy in 2006...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29763337/raman-spectroscopy-for-inverted-papilloma-a-proof-of-concept-study
#7
Marco A Mascarella, Abdulaziz Alrasheed, Naif Fnais, Ophelie Gourgas, Ghulam Jalani, Marta Cerruti, Marc A Tewfik
Inverted papillomas are tumors of the sinonasal tract with a propensity to recur. Raman spectroscopy can potentially identify inverted papillomas from other tissue based on biochemical signatures. A pilot study comparing Raman spectroscopy to histopathology for 3 types of sinonasal tissue was performed. Spectral data of biopsies from patients with normal sinonasal mucosa, chronic rhinosinusitis, and inverted papillomas are compared to histopathology using principal component analysis and linear discriminant analysis after data preprocessing...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29762324/a-giant-congenital-soft-tissue-sinonasal-fibromyxoma-of-the-nose-in-a-newborn-baby
#8
Nur Yucel Ekici, Gül Yucel, Suheyl Haytoğlu, Özgür Küllahci
Myxomas of the nose are very rare benign neoplasms. They grow slowly, infiltrate the surrounding bone cortex, and develop multiple local recurrences with no distant metastasis. Almost, even knowing seen at any age, it is very rare in newborn. The authors present a patient with sinonasal soft tissue fibromyxoma in a newborn baby nose followed by the literature.
May 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29761663/a-prospective-pilot-study-on-early-toxicity-from-a-simultaneously-integrated-boost-technique-for-canine-sinonasal-tumours-using-image-guided-intensity-modulated-radiation-therapy
#9
A Soukup, V Meier, S Pot, K Voelter, C Rohrer Bley
In order to overcome the common local treatment failure of canine sinonasal tumours, integrated boost techniques were tried in the cobalt/orthovoltage era, but dismissed because of unacceptable early (acute) toxicity. Intriguingly, a recent calculation study of a simultaneously integrated boost (SIB) technique for sinonasal irradiation using intensity-modulated radiation therapy (IMRT) predicted theoretical feasibility. In this prospective pilot study we applied a commonly used protocol of 10 × 4.2 Gy to the planning target volume (PTV) with a 20%-SIB dose to the gross tumour volume (GTV)...
May 14, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29760580/sinonasal-adenoid-cystic-carcinoma-role-of-on-site-fnac-a-case-report
#10
Santosh Tummidi, Kanchan Kothari, Roshni Patil, Shruti S Singhal, Vyoma Shah
Background: Adenoid cystic carcinoma (ACC), a rare tumor of epithelial cell origin, commonly arises from the major salivary glands. Uncommonly it may be found outside the salivary glands and it's especially rare in the nasal cavity. Case presentation: A 71-year female had complaints of swelling at the base of nose, Fine needle aspiration (FNA) from the swelling revealed features of adenoid cystic carcinoma; cell block & IHC for CD-117 was positive. Conclusions: Sino-nasal ACC (SNACC) continues to pose diagnostic and therapeutic challenges to clinicians...
2018: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/29759028/reciprocal-predictive-accuracy-of-sinonasal-symptom-severity-nasal-endoscopy-and-frequency-of-past-chronic-rhinosinusitis-exacerbations
#11
Marlene M Speth, Robert A Gaudin, Lloyd P Hoehle, Katie M Phillips, David S Caradonna, Stacey T Gray, Ahmad R Sedaghat
Objective We sought to determine whether chronic rhinosinusitis (CRS) symptom severity, endoscopic exam findings, and acute exacerbation of CRS (AECRS) frequency-all important and distinct clinical manifestations of CRS-would be predictive of each other and, therefore, inform when further assessment of each other metric should be pursued. Study Design Cross-sectional cohort study. Setting Tertiary academic rhinology clinic. Subjects and Methods In total, 241 patients with CRS were prospectively recruited and completed the 22-item Sinonasal Outcome Test (SNOT-22) to reflect CRS symptom severity...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29756404/nasal-fibroscopy-as-a-routine-screening-procedure-of-sinonasal-adenocarcinoma-of-woodworkers-french-longitudinal-case-study
#12
Julie Martin, Flora Vayr, Christophe Paris, Sébastien Vergez, Peggy Krief, Amandine Luc, Julie Corvisier, Ludovic de Gabory, Fabrice Herin
BACKGROUND: The purpose of this study was to assess the relevancy of flexible nasoendoscopy as a routine screening procedure of sinonasal adenocarcinoma among people occupationally exposed to wood dust. METHODS: This study included woodworkers, occupationally exposed to wood dust. Evaluations were scheduled at the time of inclusion (T0) and after a 2-year period (T1). A questionnaire was used for standardized data collection. The score was based on anatomic landmarks on each side that are parts of the olfactory clefts: the area of middle turbinate, the anterior part of the olfactory cleft, the top of the choanal arch, the spheno-ethmoidal recess, the posterior part of the olfactory cleft, and the middle part of the olfactory cleft...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756211/appropriateness-criteria-predict-outcomes-for-sinus-surgery-and-may-aid-in-future-patient-selection
#13
Daniel M Beswick, Jess C Mace, Zachary M Soler, Noel F Ayoub, Luke Rudmik, Adam S DeConde, Timothy L Smith
OBJECTIVES: Appropriateness criteria to determine surgical candidacy for chronic rhinosinusitis (CRS) have recently been described. This study stratified patients who underwent endoscopic sinus surgery (ESS) according to these new appropriateness criteria and evaluated postoperative improvements among appropriateness categories. METHODS: Adult patients with uncomplicated CRS electing ESS were prospectively enrolled in a multi-institutional cohort study between March 2011 and June 2015 to assess outcomes...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29755916/a-case-of-sinonasal-undifferentiated-carcinoma-with-brain-metastases
#14
Julianna Sienna, Nhu-Tram Nguyen, Julie Arsenault, Ian Hodson, Brandon Meyers
Sinonasal undifferentiated carcinoma (SNUC) is a rare aggressive neoplasm arising in the nasal cavity and paranasal sinuses. We report a unique case of an 80-year-old man who presented with a locally advanced SNUC involving the ethmoid, sphenoid, and maxillary sinuses and bilateral lymph nodes, clinical T4N2M0. Given his age and the initial extent of his primary tumour, he was treated with neoadjuvant chemotherapy followed by chemoradiation with a split course of 50 Gray (Gy) in 40 fractions delivered twice a day...
March 13, 2018: Curēus
https://www.readbyqxmd.com/read/29755274/nut-carcinoma-of-the-sinonasal-tract-infiltrating-the-orbit-in-a-man-with-birdshot-chorioretinitis
#15
Wesley Chan, Martin J Bullock, Arif F Samad, Curtis W Archibald, J Godfrey Heathcote
A 48-year-old man with a history of birdshot chorioretinitis presented with blurry vision, retro-bulbar pain and sinusitis. Though visual acuity was unaffected, he had left optic disc oedema and mild restriction of left eye abduction. His symptoms progressed quickly, with diplopia in primary gaze, epistaxis from his left nostril, and a left relative afferent pupillary defect (RAPD). On computed tomography, there was a mass in the nasal cavity that extended through the left cribriform plate and lamina papyracea and posteriorly into the optic canal...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29754975/endoscopic-endonasal-double-flap-technique-for-reconstruction-of-large-anterior-skull-base-defects-technical-note
#16
Ricardo Landini Lutaif Dolci, Alexandre Bossi Todeschini, Américo Rubens Leite Dos Santos, Paulo Roberto Lazarini
INTRODUCTION: One of the main concerns in endoscopic endonasal approaches to the skull base has been the high incidence and morbidity associated with cerebrospinal fluid leaks. The introduction and routine use of vascularized flaps allowed a marked decrease in this complication followed by a great expansion in the indications and techniques used in endoscopic endonasal approaches, extending to defects from huge tumours and previously inaccessible areas of the skull base. OBJECTIVE: Describe the technique of performing endoscopic double flap multi-layered reconstruction of the anterior skull base without craniotomy...
April 19, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29751155/depressed-mood-modulates-impact-of-chronic-rhinosinusitis-symptoms-on-quality-of-life
#17
Raphael G Banoub, Lloyd P Hoehle, Katie M Phillips, Brian J Schulman, David S Caradonna, Stacey T Gray, Ahmad R Sedaghat
BACKGROUND: It is unknown how severity of depressed mood affects the well-recognized relationship between chronic rhinosinusitis (CRS) symptom burden and decreased general health-related quality of life (QOL). OBJECTIVE: To determine if depressed mood would affect the relationship between CRS symptom burden and decreased general health-related QOL. METHODS: For this cross-sectional study, 610 participants with CRS were prospectively recruited...
May 8, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29748385/activation-of-airway-epithelial-bitter-taste-receptors-by-pseudomonas-aeruginosa-quinolones-modulates-calcium-cyclic-amp-and-nitric-oxide-signaling
#18
Jenna R Freund, Corrine J Mansfield, Laurel J Doghramji, Nithin D Adappa, James N Palmer, David W Kennedy, Danielle R Reed, Peihua Jiang, Robert J Lee
Bitter taste receptors (T2Rs), discovered in many tissues outside the tongue, have recently become potential therapeutic targets. We showed previously that airway epithelial cells express several T2Rs that activate innate immune responses that may be important for treatment of airway diseases such as chronic rhinosinusitis. It is imperative to more clearly understand what compounds activate airway T2Rs as well as their full range of functions. T2R isoforms in airway motile cilia (T2Rs 4, 14, 16, and 38) produce bactericidal levels of nitric oxide (NO) that also increase ciliary beating, promoting clearance of mucus and trapped pathogens...
May 10, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29742315/solitary-chemosensory-cells-producing-interleukin-25-and-group-2-innate-lymphoid-cells-are-enriched-in-chronic-rhinosinusitis-with-nasal-polyps
#19
Neil N Patel, Michael A Kohanski, Ivy W Maina, Vasiliki Triantafillou, Alan D Workman, Charles C L Tong, Edward C Kuan, John V Bosso, Nithin D Adappa, James N Palmer, De'Broski R Herbert, Noam A Cohen
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is commonly characterized by type-2 inflammation. It is established that group-2 innate lymphoid cells (ILC2s) are a subset of immune cells important in orchestrating mucosal type-2 response. IL-25 is an epithelial-derived cytokine that is a critical activator of ILC2s. Recent evidence demonstrates that specialized taster epithelial cells, such as solitary chemosensory cells (SCCs), may be producers of IL-25. To elucidate the relationship between SCCs and ILC2s in CRSwNP, we sought to quantify ILC2s and SCCs to determine if these cell types are enriched in nasal polyps compared to healthy sinonasal mucosa...
May 9, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29737908/prevalence-of-potential-adult-chronic-rhinosinusitis-symptoms-in-the-united-states
#20
Neil Bhattacharyya, Sapideh Gilani
Objective To determine the prevalence of chronic rhinosinusitis-related symptoms in the United States. Study Design Cross-sectional analysis of a national database. Setting Representative sampling of the US adult population. Subjects and Methods The National Health and Nutrition Examination Survey data set, taste and smell supplement 2013-2014 was analyzed for sinonasal question responses regarding discolored nasal mucus, nasal blockage, sinus pain, and dysosmia. The individual prevalences as well as the prevalence of 2 or more of these symptoms (which would be compatible with a diagnosis of chronic rhinosinusitis) were determined for the US population...
May 1, 2018: Otolaryngology—Head and Neck Surgery
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