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https://www.readbyqxmd.com/read/28070572/electrostatic-layer-by-layer-construction-of-fibrous-tmv-biofilms
#1
Brylee David B Tiu, Daniel L Kernan, Sicily B Tiu, Amy M Wen, Yi Zheng, Jonathan K Pokorski, Rigoberto C Advincula, Nicole F Steinmetz
As nature's choice in designing complex architectures, the bottom-up assembly of nanoscale building blocks offers unique solutions in achieving more complex and smaller morphologies with wide-ranging applications in medicine, energy, and materials science as compared to top-down manufacturing. In this work, we employ charged tobacco mosaic virus (TMV-wt and TMV-lys) nanoparticles in constructing multilayered fibrous networks via electrostatic layer-by-layer (LbL) deposition. In neutral aqueous media, TMV-wt assumes an anionic surface charge...
January 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28065769/habitual-and-recent-sleep-durations-graded-and-interactive-risk-for-impaired-glycemic-control-in-a-biracial-population
#2
Donald L Bliwise, Sophia A Greer, Michael K Scullin, Lawrence S Phillips
BACKGROUND AND AIMS: We examined how habitual sleep duration interacts with recent sleep (two nights) to predict morning oral glucose tolerance test results. We hypothesized short habitual and recent sleep durations would be additive for poor glucose control. METHODS: A biracial population of adults (n = 1,559) without known diabetes and recruited from the workforce of two urban universities was assessed for glycated hemoglobin and underwent oral glucose tolerance testing...
January 5, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28063221/novel-circulating-biomarkers-for-non-alcoholic-fatty-liver-disease-a-systematic-review
#3
REVIEW
Amirhossein Sahebkar, Elena Sancho, David Abelló, Jordi Camps, Jorge Joven
Currently, a liver biopsy remains the only reliable way to precisely diagnose non-alcoholic fatty liver disease (NAFLD) and establish the severity of liver injury, presence of fibrosis and architecture remodeling. However, the cost and the intrinsic invasive procedure of a liver biopsy rules it out as a gold standard diagnostic test, and the imaging test are not the best choice due to the price, and currently is being refined. The lack of a biomarker of NAFLD pushes to develop this new line of research. The aim of the present systematic review is to clarify and update all the NAFLD biomarkers described in the literature until recently...
January 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28057725/the-neuro-computational-architecture-of-value-based-selection-in-the-human-brain
#4
Philippe Domenech, Jérôme Redouté, Etienne Koechlin, Jean-Claude Dreher
Current neural models of value-based decision-making consider choices as a 2-stage process, proceeding from the "valuation" of each option under consideration to the "selection" of the best option on the basis of their subjective values. However, little is known about the computational mechanisms at play at the selection stage and its implementation in the human brain. Here, we used drift-diffusion models combined with model-based functional magnetic resonance imaging, effective connectivity, and multivariate pattern analysis to characterize the neuro-computational architecture of value-based decisions...
January 4, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28050473/evaluation-of-sinonasal-diseases-by-computed-tomography
#5
Rashmi Kandukuri, Suresh Phatak
INTRODUCTION: Computed Tomography (CT) plays an important diagnostic role in patients with sinonasal diseases and determines the treatment. The CT images clearly show fine structural architecture of bony anatomy thereby determining various anatomical variation, extent of disease and characterization of various inflammatory, benign and malignant sinonasal diseases. AIM: To evaluate sensitivity and specificity of CT in diagnosis of sinonasal diseases and to characterise the benign and malignant lesions with the help of various CT parameters...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28049701/three-dimensional-genome-organization-and-function-in-drosophila
#6
Yuri B Schwartz, Giacomo Cavalli
Understanding how the metazoan genome is used during development and cell differentiation is one of the major challenges in the postgenomic era. Early studies in Drosophila suggested that three-dimensional (3D) chromosome organization plays important regulatory roles in this process and recent technological advances started to reveal connections at the molecular level. Here we will consider general features of the architectural organization of the Drosophila genome, providing historical perspective and insights from recent work...
January 2017: Genetics
https://www.readbyqxmd.com/read/28047596/su-f-i-60-icc-miwg-displays-final-recommendations-for-visualization-of-medical-content-on-color-display-systems
#7
T Kimpe, P Green, C Revie, M Flynn
PURPOSE: Use of color images in medical imaging has increased significantly the last few years. There is no agreement yet on what is an appropriate visualization framework for color medical images. This lack of standardization results into large variability of color appearance and makes consistency and quality assurance a challenge. The ICC Medical-Imaging-Working-Group (MIWG) has defined recommendations for visualization of medical content on color display systems, whereby DICOM GSDF images, pseudo color images and color accurate images can all be presented effectively on the same display...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044978/-nudges-relevance-limitations-and-ethical-issues-specifically-in-health-policy
#8
Caroline Huyard
The concept of "nudge" has recently spread accross the field of research that addresses the issue of health behaviours change. According to Thaler and Sunstein (2008) a nudge is "any aspect of the choice architecture that alters people's behavior in a predictable way without forbidding any options or significantly changing their economic incentives". Similar concepts, such as persuasive technology or manipulation, have been studied for decades in the fields of design, psychology or communication. The novelty of the concept of "nudge"' lies in its particular political purpose, namely libertarian paternalism...
December 2016: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28025895/advanced-diagnostic-plan-applied-to-the-royal-villa-in-naples
#9
Caterina Gattuso, Philomène Gattuso, Jolanda Mastroianni, Valentina Roviello, Luigi Campanella
To achieve adequate restoration project, the moment of choice of the type of intervention is a very delicate phase that necessarily involves a thorough understanding of the asset in all its aspects, as the location, the history, the architecture, the state of preservation, the pathologies causing the degradation, the degradation in itself, the analysis of constituent materials. The set of all that can be investigated on a product (cultural), to obtaining important information for subsequent maintenance, conservation and/or restoration actions, is what is called a diagnostic plan...
December 27, 2016: Natural Product Research
https://www.readbyqxmd.com/read/28009280/three-dimensional-architecture-of-the-human-brca1-a-histone-deubiquitinase-core-complex
#10
Otto J P Kyrieleis, Pauline B McIntosh, Sarah R Webb, Lesley J Calder, Janette Lloyd, Nisha A Patel, Stephen R Martin, Carol V Robinson, Peter B Rosenthal, Stephen J Smerdon
BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It is recruited to damaged chromatin as a component of the BRCA1-A deubiquitinase, which cleaves K63-linked ubiquitin chains attached to histone H2A and H2AX. BRCA1-A contributes to checkpoint regulation, repair pathway choice, and HR repair efficiency through molecular mechanisms that remain largely obscure. The structure of an active core complex comprising two Abraxas/BRCC36/BRCC45/MERIT40 tetramers determined by negative-stain electron microscopy (EM) reveals a distorted V-shape architecture in which a dimer of Abraxas/BRCC36 heterodimers sits at the base, with BRCC45/Merit40 pairs occupying each arm...
December 20, 2016: Cell Reports
https://www.readbyqxmd.com/read/27933110/profiling-lung-adenocarcinoma-by-liquid-biopsy-can-one-size-fit-all
#11
Harry W Clifford, Amy P Cassidy, Courtney Vaughn, Evaline S Tsai, Bianka Seres, Nirmesh Patel, Hannah L O'Neill, Emil Hewage, John W Cassidy
BACKGROUND: Cancer is first and foremost a disease of the genome. Specific genetic signatures within a tumour are prognostic of disease outcome, reflect subclonal architecture and intratumour heterogeneity, inform treatment choices and predict the emergence of resistance to targeted therapies. Minimally invasive liquid biopsies can give temporal resolution to a tumour's genetic profile and allow the monitoring of treatment response through levels of circulating tumour DNA (ctDNA). However, the detection of ctDNA in repeated liquid biopsies is currently limited by economic and time constraints associated with targeted sequencing...
2016: Cancer Nanotechnology
https://www.readbyqxmd.com/read/27919153/-nudge-strategies-at-a-glance-an-overview-more-freedom-or-new-paternalism
#12
Luca Leone
Under the theoretical assumptions of individual bounded rationality and of behavioural psychology about human actions and agency, nudge has been promoted as an alternative to traditional regulatory tools, characterized by being inexpensive, choice-preserving, and bound to promote legitimate goals and citizens' welfare within through specific choice architectures. Applicable to several domains, health included, the nudging approach runs in connection with requests and needs arising from marketing strategies, with the aim of maximizing economic rationality and efficiency...
November 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27917669/use-of-core-biopsy-in-diagnosing-cervical-lymphadenopathy-a-viable-alternative-to-surgical-excisional-biopsy-of-lymph-nodes
#13
D Allin, S David, A Jacob, N Mir, A Giles, N Gibbins
OBJECTIVES Lymphoma often presents with a neck mass and while fine-needle aspiration cytology may be suggestive, tissue biopsy is required for reliable diagnosis and classification of a lymphoma that is sufficient to deliver the correct treatment for the patient. Traditionally, excisional biopsy of a lymph node has been the standard method of tissue sampling, providing ample tissue for assessment. However, this requires theatre time, and preceding fine-needle aspiration cytology, which may incur a delay. With careful use of tissue, coupled with advances in immunohistochemical and molecular investigative techniques, core biopsy provides a possible alternative to traditional fine-needle aspiration and excisional biopsy...
December 5, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27896989/opening-the-door-to-the-large-scale-use-of-clinical-lab-measures-for-association-testing-exploring-different-methods-for-defining-phenotypes
#14
Christopher R Bauer, Daniel Lavage, John Snyder, Joseph Leader, J Matthew Mahoney, Sarah A Pendergrass
The past decade has seen exponential growth in the numbers of sequenced and genotyped individuals and a corresponding increase in our ability of collect and catalogue phenotypic data for use in the clinic. We now face the challenge of integrating these diverse data in new ways new that can provide useful diagnostics and precise medical interventions for individual patients. One of the first steps in this process is to accurately map the phenotypic consequences of the genetic variation in human populations. The most common approach for this is the genome wide association study (GWAS)...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27894378/an-experimental-approach-to-linguistic-representation
#15
Holly P Branigan, Martin J Pickering
Within the cognitive sciences, most researchers assume that it is the job of linguists to investigate how language is represented, and that they do so largely by building theories based on explicit judgments about patterns of acceptability - whereas it is the task of psychologists to determine how language is processed, and that in doing so, they do not typically question the linguists' representational assumptions. We challenge this division of labor, by arguing that structural priming provides an implicit method of investigating linguistic representations that should end the current reliance on acceptability judgments...
November 29, 2016: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/27893365/design-and-choice-of-visual-display-solutions-in-the-training-domain
#16
Amela Sadagic
Visual display solutions are a key element of computer-based system architectures intended for human-system interaction. Particularly in the training domain, an ill-matched visual display can render a system unusable or ineffectual, which may cause underutilization or a negative transfer of training. This article outlines a set of approaches and best practices used in research efforts focused on the design of novel military training systems.
November 2016: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/27890020/choice-architecture-to-promote-fruit-and-vegetable-purchases-by-families-participating-in-the-special-supplemental-program-for-women-infants-and-children-wic-randomized-corner-store-pilot-study
#17
Anne N Thorndike, Oliver-John M Bright, Melissa A Dimond, Ronald Fishman, Douglas E Levy
OBJECTIVE: To conduct a pilot study to determine if improving the visibility and quality of fresh produce (choice architecture) in corner stores would increase fruit/vegetable purchases by families participating in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). DESIGN: Six stores were randomly assigned to choice architecture intervention or control. Store-level WIC sales data were provided by the state. Primary outcomes were WIC fruit/vegetable voucher and non-fruit/vegetable voucher sales, comparing trends from baseline (December 2012-October 2013) with the five-month intervention period (December 2013-April 2014)...
November 28, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27869075/-cell-therapies-for-cardiopathies-the-shift-of-paradigms
#18
Jean-Thomas Vilquin, Jessy Etienne
Heart failure is a major concern for public health systems, and several approaches of cellular therapy are being investigated with the goal of improving the function of these failing hearts. Many cell types have been used (skeletal myoblasts, hematopoietic, endothelial or mesenchymal progenitors, cardiac cells…), most often in the indication of post-ischemic heart failure rather than in the indication of genetic dilated cardiomyopathy. It is easier, indeed, to target a restricted area than the whole myocardium...
November 2016: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/27860169/environmental-interventions-for-altering-eating-behaviours-of-employees-in-the-workplace-a-systematic-review
#19
REVIEW
J Allan, D Querstret, K Banas, M de Bruin
Environmental, or 'choice-architecture', interventions aim to change behaviour by changing properties/contents of the environment and are commonly used in the workplace to promote healthy behaviours in employees. The present review aimed to evaluate and synthesize the evidence surrounding the effectiveness of environmental interventions targeting eating behaviour in the workplace. A systematic search identified 8157 articles, of which 22 were included in the current review. All included studies were coded according to risk of bias and reporting quality and were classified according to the emergent typology of choice-architecture interventions...
November 17, 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27847762/endovascular-treatment-of-symptomatic-vertebral-artery-dissecting-aneurysms
#20
Jinsol Han, Dong-Jun Lim, Sung-Kon Ha, Jong-Il Choi, Sung-Won Jin, Se-Hoon Kim
OBJECTIVE: Vertebral artery dissecting aneurysms (VADAs) are rare and many debates are present about treatment options. We review types and efficacy of our endovascular treatments and establish a safe endovascular therapeutic strategy regard to the angio-architecture of VADAs. MATERIALS AND METHODS: Between July 2008 and October 2015, we treated 22 patients with symptomatic VADAs. Fifteen patients presented with subarachnoid hemorrhage from the ruptured VADAs, digital subtraction angiography and magnetic resonance image confirmed the diagnosis and endovascular treatments were followed as their angio-architecture...
September 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
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