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https://www.readbyqxmd.com/read/28734365/automatic-feed-phase-identification-in-multivariate-bioprocess-profiles-by-sequential-binary-classification
#1
Ramin Nikzad-Langerodi, Edwin Lughofer, Susanne Saminger-Platz, Thomas Zahel, Patrick Sagmeister, Christoph Herwig
In this paper, we propose a new strategy for retrospective identification of feed phases from online sensor-data enriched feed profiles of an Escherichia Coli (E. coli) fed-batch fermentation process. In contrast to conventional (static), data-driven multi-class machine learning (ML), we exploit process knowledge in order to constrain our classification system yielding more parsimonious models compared to static ML approaches. In particular, we enforce unidirectionality on a set of binary, multivariate classifiers trained to discriminate between adjacent feed phases by linking the classifiers through a one-way switch...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28730671/many-faces-of-rationality-implications-of-the-great-rationality-debate-for-clinical-decision-making
#2
Benjamin Djulbegovic, Shira Elqayam
Given that more than 30% of healthcare costs are wasted on inappropriate care, suboptimal care is increasingly connected to the quality of medical decisions. It has been argued that personal decisions are the leading cause of death, and 80% of healthcare expenditures result from physicians' decisions. Therefore, improving healthcare necessitates improving medical decisions, ie, making decisions (more) rational. Drawing on writings from The Great Rationality Debate from the fields of philosophy, economics, and psychology, we identify core ingredients of rationality commonly encountered across various theoretical models...
July 20, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28715989/use-and-effectiveness-of-behavioural-economics-in-interventions-for-lifestyle-risk-factors-of-non-communicable-diseases-a-systematic-review-with-policy-implications
#3
Oana M Blaga, Livia Vasilescu, Razvan M Chereches
AIM: There is limited evidence on what behavioural economics strategies are effective and can be used to inform non-communicable diseases (NCDs) public health policies designed to reduce overeating, excessive drinking, smoking, and physical inactivity. The aim of the review is to examine the evidence on the use and effectiveness of behavioural economics insights on reducing NCDs lifestyle risk factors. METHODS: Medline, Embase, PsycINFO, and EconLit were searched for studies published between January 2002 and July 2016 and reporting empirical, non-pharmacological, interventional research focusing on reducing at least one NCDs lifestyle risk factor by employing a behavioural economics perspective...
July 1, 2017: Perspectives in Public Health
https://www.readbyqxmd.com/read/28710548/retrospective-evaluation-and-seeg-trajectory-analysis-for-interactive-multi-trajectory-planner-assistant
#4
Davide Scorza, Elena De Momi, Lisa Plaino, Gaetano Amoroso, Gabriele Arnulfo, Massimo Narizzano, Luis Kabongo, Francesco Cardinale
PURPOSE: Focal epilepsy is a neurological disease that can be surgically treated by removing area of the brain generating the seizures. The stereotactic electroencephalography (SEEG) procedure allows patient brain activity to be recorded in order to localize the onset of seizures through the placement of intracranial electrodes. The planning phase can be cumbersome and very time consuming, and no quantitative information is provided to neurosurgeons regarding the safety and efficacy of their trajectories...
July 14, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28705191/knowledge-and-understanding-of-health-insurance-challenges-and-remedies
#5
Andrew J Barnes, Yaniv Hanoch
As coverage is expanded in health systems that rely on consumers to choose health insurance plans that best meet their needs, interest in whether consumers possess sufficient understanding of health insurance to make good coverage decisions is growing. The recent IJHPR article by Green and colleagues-examining understanding of supplementary health insurance (SHI) among Israeli consumers-provides an important and timely answer to the above question. Indeed, their study addresses similar problems to the ones identified in the US health care market, with two notable findings...
July 13, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28704965/progress-evaluation-for-the-restaurant-industry-assessed-by-a-voluntary-marketing-mix-and-choice-architecture-framework-that-offers-strategies-to-nudge-american-customers-toward-healthy-food-environments-2006-2017
#6
Vivica Kraak, Tessa Englund, Sarah Misyak, Elena Serrano
Consumption of restaurant food and beverage products high in fat, sugar and sodium contribute to obesity and non-communicable diseases. We evaluated restaurant-sector progress to promote healthy food environments for Americans. We conducted a desk review of seven electronic databases (January 2006-January 2017) to examine restaurant strategies used to promote healthful options in the United States (U.S.). Evidence selection (n = 84) was guided by the LEAD principles (i.e., locate, evaluate, and assemble evidence to inform decisions) and verified by data and investigator triangulation...
July 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28677028/why-nudges-coerce-experimental-evidence-on-the-architecture-of-regulation
#7
Adam Hill
Critics frequently argue that nudges are more covert, less transparent, and more difficult to monitor than traditional regulatory tools. Edward Glaeser, for example, argues that "[p]ublic monitoring of soft paternalism is much more difficult than public monitoring of hard paternalism". As one of the leading proponents of soft paternalism, Cass Sunstein, acknowledges, while "[m]andates and commands are highly visible", soft paternalism, "and some nudges in particular[,] may be invisible". In response to this challenge, proponents of nudging argue that invisibility for any given individual in a particular choice environment is compatible with "careful public scrutiny" of the nudge...
July 4, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28671677/effects-of-proton-versus-photon-irradiation-on-lymph-angiogenic-inflammatory-proliferative-and-anti-tumor-immune-responses-in-head-and-neck-squamous-cell-carcinoma
#8
M Lupu-Plesu, A Claren, S Martial, P-D N'Diaye, K Lebrigand, N Pons, D Ambrosetti, I Peyrottes, J Feuillade, J Hérault, M Dufies, J Doyen, G Pagès
The proximity of organs at risk makes the treatment of head and neck squamous cell carcinoma (HNSCC) challenging by standard radiotherapy. The higher precision in tumor targeting of proton (P) therapy could promote it as the treatment of choice for HNSCC. Besides the physical advantage in dose deposition, few is known about the biological impact of P versus photons (X) in this setting. To investigate the comparative biological effects of P versus X radiation in HNSCC cells, we assessed the relative biological effectiveness (RBE), viability, proliferation and mRNA levels for genes involved in (lymph)angiogenesis, inflammation, proliferation and anti-tumor immunity...
July 3, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28669496/using-choice-architecture-to-exploit-a-university-distinct-urban-mine
#9
REVIEW
Xavier Pierron, Ian D Williams, Peter J Shaw, Victoria Cleaver
There are widespread concerns regarding the potential future scarcity of ferrous and non-ferrous materials. However, there are already potentially rich reserves of secondary materials via high ownership of Electrical and Electronic Equipment (EEE) in economically-developed nations. Young people are particularly high consumers of EEE, thus university students and campuses may present an opportunity to harness this potential. University Distinct Urban Mines (DUM) may be used to exemplify how potential reserves of secondary metals may be exploited, and could contribute to the transition from a linear to a circular economy...
June 29, 2017: Waste Management
https://www.readbyqxmd.com/read/28659838/the-robust-running-ape-unraveling-the-deep-underpinnings-of-coordinated-human-running-proficiency
#10
REVIEW
John Kiely
In comparison to other mammals, humans are not especially strong, swift or supple. Nevertheless, despite these apparent physical limitations, we are among Natures most superbly well-adapted endurance runners. Paradoxically, however, notwithstanding this evolutionary-bestowed proficiency, running-related injuries, and Overuse syndromes in particular, are widely pervasive. The term 'coordination' is similarly ubiquitous within contemporary coaching, conditioning, and rehabilitation cultures. Various theoretical models of coordination exist within the academic literature...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28657760/effect-of-monovalent-ion-parameters-on-molecular-dynamics-simulations-of-g-quadruplexes
#11
Marek Havrila, Petr Stadlbauer, Barira Islam, Michal Otyepka, Jiri Sponer
G-quadruplexes (GQs) are key non-canonical DNA and RNA architectures stabilized by desolvated monovalent cations present in their central channels. We analyze extended atomistic molecular dynamics simulations (~ 580 µs in total) of GQs with eleven monovalent cation parametrizations, assessing GQ overall structural stability, dynamics of internal cations and distortions of the G-tetrad geometries. Majority of simulations were executed with the SPC/E water model, however, test simulations with TIP3P and OPC water models are also reported...
June 28, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28656622/a-population-level-atlas-of-mus-musculus-craniofacial-skeleton-and-automated-image-based-shape-analysis
#12
A Murat Maga, Nicholas J Tustison, Brian B Avants
Laboratory mice are staples for evo/devo and genetics studies. Inbred strains provide a uniform genetic background to manipulate and understand gene-environment interactions, while their crosses have been instrumental in studies of genetic architecture, integration and modularity, and mapping of complex biological traits. Recently, there have been multiple large-scale studies of laboratory mice to further our understanding of the developmental basis, evolution, and genetic control of shape variation in the craniofacial skeleton (i...
June 28, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28655176/a-systematic-review-and-meta-analysis-of-the-effectiveness-of-nudging-to-increase-fruit-and-vegetable-choice
#13
Valérie J V Broers, Céline De Breucker, Stephan Van den Broucke, Olivier Luminet
Background: Nudging refers to interventions that organize the choice architecture in order to alter people's behaviour in a predictable way without forbidding any options or significantly changing their economic incentives. As a strategy to encourage healthy behaviour, nudging can serve as a complement to health education. However, the empirical evidence regarding the effectiveness of nudging as a way to influence food choice remains contradictory. To address this issue, a systematic review and meta-analysis was conducted to test the effects of nudging to encourage people to select more fruit and vegetables...
June 25, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28653668/reminders-of-past-choices-bias-decisions-for-reward-in-humans
#14
Aaron M Bornstein, Mel W Khaw, Daphna Shohamy, Nathaniel D Daw
We provide evidence that decisions are made by consulting memories for individual past experiences, and that this process can be biased in favour of past choices using incidental reminders. First, in a standard rewarded choice task, we show that a model that estimates value at decision-time using individual samples of past outcomes fits choices and decision-related neural activity better than a canonical incremental learning model. In a second experiment, we bias this sampling process by incidentally reminding participants of individual past decisions...
June 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28650624/precise-steric-control-over-2d-versus-3d-self-assembly-of-antimony-iii-alkoxide-cages-through-strong-secondary-bonding-interactions
#15
Shiva Moaven, Jingze Yu, Jason Yasin, Daniel K Unruh, Anthony F Cozzolino
Antimony(III) alkoxide cages were designed as building blocks for predictable supramolecular self-assembly. Supramolecular synthons featuring two Sb···O secondary bonding interactions (SBIs), each SBI stronger than 30 kJ/mol, were used to drive the formation of the supramolecular architectures. Judicious choice of pendant groups provided predictable control over the formation of self-assembled 3D columnar helices, which crystallized with hollow morphologies, or a self-assembled 2D bilayer. The Sb-O stretching frequency provides a spectroscopic signature of Sb···O SBI formation...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28646763/deep-neural-mapping-support-vector-machines
#16
Yujian Li, Ting Zhang
The choice of kernel has an important effect on the performance of a support vector machine (SVM). The effect could be reduced by NEUROSVM, an architecture using multilayer perceptron for feature extraction and SVM for classification. In binary classification, a general linear kernel NEUROSVM can be theoretically simplified as an input layer, many hidden layers, and an SVM output layer. As a feature extractor, the sub-network composed of the input and hidden layers is first trained together with a virtual ordinary output layer by backpropagation, then with the output of its last hidden layer taken as input of the SVM classifier for further training separately...
June 21, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28644558/current-understanding-of-cancer-stem-cells-review-of-their-radiobiology-and-role-in-head-and-neck-cancers
#17
REVIEW
Paul Ambrose Reid, Puthenparampil Wilson, Yanrui Li, Loredana Gabriela Marcu, Eva Bezak
Evidence of cancer cells that bear attributes analogous to those of normal stem cells has developed a hierarchical model of cancer's architecture and progression. This subset of cancer stem cells (CSCs) drives the progression and therapy resistance of cancers. Research to identify the phenotypes of these CSCs presents evidence of a subpopulation that is more resistant to therapy and may proliferate in response. Literature shows that CSCs typically represent around 1%-10% of cell populations in head and neck cancer but this proportion may increase in response to a therapeutic radiation dose...
June 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28634673/b-mode-and-doppler-ultrasound-of-chronic-kidney-disease-in-dogs-and-cats
#18
REVIEW
Nathália Bragato, Naida Cristina Borges, Maria Clorinda Soares Fioravanti
Ultrasound is the imaging test of choice for renal evaluation, because it provides information about the position, size, shape, internal architecture and hemodynamics of the kidneys without harming the patient. In chronic kidney disease, the main findings observed in B-mode ultrasound images are increased cortical echogenicity, loss of corticomedullary differentiation, reduced renal volume and irregular renal contour, and when these changes are associated, they are indicative of end-stage renal disease. However, the cause of kidney disease cannot be determined by ultrasonography, but must be confirmed by means of biopsy, although the presence of ultrasonographic changes indicative of the end-stage of the disease may contraindicate this procedure...
June 21, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/28632258/materials-and-microfluidics-enabling-the-efficient-isolation-and-analysis-of-circulating-tumour-cells
#19
REVIEW
Joshua M Jackson, Małgorzata A Witek, Joyce W Kamande, Steven A Soper
We present a critical review of microfluidic technologies and material effects on the analyses of circulating tumour cells (CTCs) selected from the peripheral blood of cancer patients. CTCs are a minimally invasive source of clinical information that can be used to prognose patient outcome, monitor minimal residual disease, assess tumour resistance to therapeutic agents, and potentially screen individuals for the early diagnosis of cancer. The performance of CTC isolation technologies depends on microfluidic architectures, the underlying principles of isolation, and the choice of materials...
July 17, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28616251/physical-micro-environment-interventions-for-healthier-eating-in-the-workplace-protocol-for-a-stepped-wedge-randomised-controlled-pilot-trial
#20
Milica Vasiljevic, Emma Cartwright, Rachel Pechey, Gareth J Hollands, Dominique-Laurent Couturier, Susan A Jebb, Theresa M Marteau
BACKGROUND: An estimated one third of energy is consumed in the workplace. The workplace is therefore an important context in which to reduce energy consumption to tackle the high rates of overweight and obesity in the general population. Altering environmental cues for food selection and consumption-physical micro-environment or 'choice architecture' interventions-has the potential to reduce energy intake. The first aim of this pilot trial is to estimate the potential impact upon energy purchased of three such environmental cues (size of portions, packages and tableware; availability of healthier vs...
2017: Pilot and Feasibility Studies
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