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https://www.readbyqxmd.com/read/27102531/improving-detection-of-colorectal-dysplasia-in-inflammatory-bowel-disease-surveillance
#1
EDITORIAL
Tonya Kaltenbach, Kenneth R McQuaid, Roy Soetikno, Loren Laine
No abstract text is available yet for this article.
May 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/26866420/paradigm-shift-in-the-surveillance-and-management-of-dysplasia-in-inflammatory-bowel-disease-west
#2
REVIEW
Roy Soetikno, Tonya Kaltenbach, Kenneth R McQuaid, Venkataraman Subramanian, Rahul Kumar, Alan N Barkun, Loren Laine
Patients with long-standing inflammatory bowel disease (IBD) colitis have a 2.4-fold higher risk of developing colorectal cancer (CRC) than the general population, for both ulcerative colitis (UC) and Crohn's disease (CD) colitis. Surveillance colonoscopy is recommended to detect early CRC and dysplasia. Most dysplasia discovered in patients with IBD is actually visible. Recently published SCENIC (Surveillance for Colorectal Endoscopic Neoplasia Detection and Management in Inflammatory Bowel Disease Patients: International Consensus Recommendations) consensus statements provide unifying recommendations for the optimal surveillance and management of dysplasia in IBD...
April 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/26364967/a-roadmap-to-the-implementation-of-chromoendoscopy-in-inflammatory-bowel-disease-colonoscopy-surveillance-practice
#3
Silvia Sanduleanu, Tonya Kaltenbach, Alan Barkun, Robert P McCabe, Fernando Velayos, Michael F Picco, Loren Laine, Roy Soetikno, Kenneth R McQuaid
No abstract text is available yet for this article.
January 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/25936449/protective-association-of-colonoscopy-against-proximal-and-distal-colon-cancer-and-patterns-in-interval-cancer
#4
Amandeep K Shergill, Erin E Conners, Kenneth R McQuaid, Sara Epstein, James C Ryan, Janak N Shah, John Inadomi, Ma Somsouk
BACKGROUND: The protective effect of colonoscopy against proximal colorectal cancer is variable and depends on the detection and complete removal of precancerous polyps. OBJECTIVE: To estimate the efficacy of colonoscopy in a medical center with open-access screening colonoscopy since 1998. DESIGN: Nested case-control study with incidence density sampling. SETTING: University-affiliated Veterans Affairs Medical Center...
September 2015: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/25811360/site-specific-differences-in-t-cell-frequencies-and-phenotypes-in-the-blood-and-gut-of-hiv-uninfected-and-art-treated-hiv-adults
#5
Steven A Yukl, Amandeep K Shergill, Valerie Girling, Qingsheng Li, Maudi Killian, Lorrie Epling, Peilin Li, Philipp Kaiser, Ashley Haase, Diane V Havlir, Kenneth McQuaid, Elizabeth Sinclair, Joseph K Wong
Gastrointestinal T lymphocytes are critical for mucosal immunity and HIV pathogenesis, yet little is known about normal T cell numbers and phenotypes in different regions of the gut, or the degree to which ART can restore levels to those of HIV-uninfected individuals. To investigate these questions, we measured T cell frequencies and markers of memory, activation, anergy, and homing in the blood, ileum, and rectum of HIV- and ART-suppressed HIV+ adults. In HIV- individuals, T cell frequencies and phenotypes differed significantly between sites...
2015: PloS One
https://www.readbyqxmd.com/read/25708752/scenic-international-consensus-statement-on-surveillance-and-management-of-dysplasia-in-inflammatory-bowel-disease
#6
Loren Laine, Tonya Kaltenbach, Alan Barkun, Kenneth R McQuaid, Venkataraman Subramanian, Roy Soetikno
No abstract text is available yet for this article.
March 2015: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/25702852/scenic-international-consensus-statement-on-surveillance-and-management-of-dysplasia-in-inflammatory-bowel-disease
#7
Loren Laine, Tonya Kaltenbach, Alan Barkun, Kenneth R McQuaid, Venkataraman Subramanian, Roy Soetikno
No abstract text is available yet for this article.
March 2015: Gastroenterology
https://www.readbyqxmd.com/read/25387891/real-time-optical-diagnosis-for-diminutive-colorectal-polyps-using-narrow-band-imaging-the-valid-randomised-clinical-trial
#8
RANDOMIZED CONTROLLED TRIAL
Tonya Kaltenbach, Amit Rastogi, Robert V Rouse, Kenneth R McQuaid, Tohru Sato, Ajay Bansal, Jon C Kosek, Roy Soetikno
BACKGROUND: Diminutive (≤ 5 mm) colorectal polyps are common, and overwhelmingly benign. Routinely, after polypectomy, they are examined pathologically to determine the surveillance intervals. Advances in equipment and techniques, such as narrow-band imaging (NBI) colonoscopy, now permit reliable real-time optical diagnosis. METHODS: We conducted a randomised single-masked study involving three institutions to determine whether optical diagnosis of diminutive colorectal polyps meets clinical practice standards and reduces the need for histopathology...
October 2015: Gut
https://www.readbyqxmd.com/read/25264764/endoscopists-can-sustain-high-performance-for-the-optical-diagnosis-of-colorectal-polyps-following-standardized-and-continued-training
#9
RANDOMIZED CONTROLLED TRIAL
Sarah K McGill, Roy Soetikno, Amit Rastogi, Robert V Rouse, Tohru Sato, Ajay Bansal, Kenneth McQuaid, Tonya Kaltenbach
BACKGROUND AND STUDY AIMS: The learning curve for optical diagnosis of colorectal polyps with the narrow-band imaging (NBI) is unknown. To forego histological analysis of diminutive polyps diagnosed optically with high confidence, guidelines recommend ≥ 90 % negative predictive value (NPV) and concordance of ≥ 90 % for surveillance intervals predicted optically and histologically. We aimed to study the learning of optical diagnosis for colorectal polyps. PATIENTS AND METHODS: We studied five endoscopists as part of a randomized multisite trial comparing near-focus and standard-focus views for optical diagnosis...
March 2015: Endoscopy
https://www.readbyqxmd.com/read/25258105/analysis-of-wntless-wls-expression-in-gastric-ovarian-and-breast-cancers-reveals-a-strong-association-with-her2-overexpression
#10
Jonathan Stewart, Jacqueline James, Glenn W McCluggage, Stephen McQuaid, Kenneth Arthur, David Boyle, Paul Mullan, Darragh McArt, Benedict Yan, Gareth Irwin, D Paul Harkin, Lei Zhengdeng, Chee-Wee Ong, Jia Yu, David M Virshup, Manuel Salto-Tellez
The oncogenic role of WNT is well characterized. Wntless (WLS) (also known as GPR177, or Evi), a key modulator of WNT protein secretion, was recently found to be highly overexpressed in malignant astrocytomas. We hypothesized that this molecule may be aberrantly expressed in other cancers known to possess aberrant WNT signaling such as ovarian, gastric, and breast cancers. Immunohistochemical analysis using a TMA platform revealed WLS overexpression in a subset of ovarian, gastric, and breast tumors; this overexpression was associated with poorer clinical outcomes in gastric cancer (P=0...
March 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/24975529/quality-bowel-preparation-for-surveillance-colonoscopy-in-patients-with-inflammatory-bowel-disease-is-a-must
#11
REVIEW
Andrew Nett, Fernando Velayos, Kenneth McQuaid
Colonoscopy is routinely performed in patients with inflammatory bowel disease (IBD) for surveillance of dysplasia. Thorough bowel preparation is necessary to facilitate lesion detection. Patients with IBD do not have poorer bowel preparation outcomes but may have decreased preparation tolerance affecting adherence to surveillance protocols. A low-fiber prepreparation diet may improve preparation tolerance without affecting preparation quality. The standard preparation regimen should consist of split-dose administration of a polyethylene glycol-based purgative...
July 2014: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/23852128/the-distribution-of-hiv-dna-and-rna-in-cell-subsets-differs-in-gut-and-blood-of-hiv-positive-patients-on-art-implications-for-viral-persistence
#12
Steven A Yukl, Amandeep K Shergill, Terence Ho, Maudi Killian, Valerie Girling, Lorrie Epling, Peilin Li, Lisa K Wong, Pierre Crouch, Steven G Deeks, Diane V Havlir, Kenneth McQuaid, Elizabeth Sinclair, Joseph K Wong
Even with optimal antiretroviral therapy, human immunodeficiency virus (HIV) persists in plasma, blood cells, and tissues. To develop new therapies, it is essential to know what cell types harbor residual HIV. We measured levels of HIV DNA, RNA, and RNA/DNA ratios in sorted subsets of CD4+ T cells (CCR7+, transitional memory, and effector memory) and non-CD4+ T leukocytes from blood, ileum, and rectum of 8 ART-suppressed HIV-positive subjects. Levels of HIV DNA/million cells in CCR7+ and effector memory cells were higher in the ileum than blood...
October 15, 2013: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/23583483/the-detection-of-nonpolypoid-flat-and-depressed-colorectal-neoplasms-in-patients-with-inflammatory-bowel-disease
#13
REVIEW
Roy Soetikno, Venkataraman Subramanian, Tonya Kaltenbach, Robert V Rouse, Silvia Sanduleanu, Noriko Suzuki, Shinji Tanaka, Kenneth McQuaid
No abstract text is available yet for this article.
June 2013: Gastroenterology
https://www.readbyqxmd.com/read/22446056/our-new-president-loren-a-laine-md
#14
EDITORIAL
M Brian Fennerty, Kenneth McQuaid
No abstract text is available yet for this article.
May 2012: Gastroenterology
https://www.readbyqxmd.com/read/22381532/randomized-trial-of-standard-versus-magnetic-endoscope-imaging-colonoscopes-for-unsedated-colonoscopy
#15
RANDOMIZED CONTROLLED TRIAL
Amandeep K Shergill, Kenneth R McQuaid, Arn Deleon, Michelle McAnanama, Janak N Shah
BACKGROUND: Unsedated colonoscopy has potential benefits, including decreased costs and decreased risks. OBJECTIVE: To determine whether patient comfort during unsedated colonoscopy can be improved through the use of a magnetic endoscopic imaging (MEI) colonoscope compared with a standard colonoscope. DESIGN: Prospective, patient-blinded, randomized, controlled trial. SETTING: San Francisco Veterans Affairs Medical Center...
May 2012: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/22138934/potential-use-of-telemedicine-to-provide-outpatient-care-for-inflammatory-bowel-disease
#16
RANDOMIZED CONTROLLED TRIAL
Michael Krier, Tonya Kaltenbach, Kenneth McQuaid, Roy Soetikno
OBJECTIVES: Patients with inflammatory bowel disease (IBD) often experience barriers to subspecialty access. We applied telemedicine, using a new computerized system called Collaborative Imaging, to resolve these barriers. We studied patients' experience and satisfaction, and clinic throughput. METHODS: We performed a prospective randomized controlled pilot study at a Veterans Affairs hospital, assigning patients into two groups: telemedicine encounter, with the IBD specialist remotely located, and standard encounter...
December 2011: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/22056302/colonoscopy-with-clipping-is-useful-in-the-diagnosis-and-treatment-of-diverticular-bleeding
#17
Tonya Kaltenbach, Rabindra Watson, Janak Shah, Shai Friedland, Tohru Sato, Amandeep Shergill, Kenneth McQuaid, Roy Soetikno
BACKGROUND & AIMS: Diverticular bleeding is the most common cause of acute severe lower gastrointestinal bleeding (LGIB) in Western countries. Diagnostic and therapeutic approaches, including endoscopy, radiology, or surgery, have not been standardized. We investigated colonoscopy as a first-line modality to diagnose and manage patients with LGIB. METHODS: We performed a retrospective study of data collected from 2 tertiary Veterans hospitals of 64 patients (61 men, 76 ± 11 years) with acute severe diverticular bleeding, based on colonoscopy examination...
February 2012: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/21873253/reduced-cathartic-bowel-preparation-for-ct-colonography-prospective-comparison-of-2-l-polyethylene-glycol-and-magnesium-citrate
#18
RANDOMIZED CONTROLLED TRIAL
Alexander W Keedy, Judy Yee, Rizwan Aslam, Stefanie Weinstein, Luis A Landeras, Janak N Shah, Kenneth R McQuaid, Benjamin M Yeh
PURPOSE: To prospectively compare adequacy of colonic cleansing, adequacy of solid stool and fluid tagging, and patient acceptance by using reduced-volume, 2-L polyethylene glycol (PEG) versus magnesium citrate bowel preparations for CT colonography. MATERIALS AND METHODS: This study was approved by the institutional Committee on Human Research and was compliant with HIPAA; all patients provided written consent. In this randomized, investigator-blinded study, 50 patients underwent oral preparation with either a 2-L PEG or a magnesium citrate solution, tagging with oral contrast agents, and subsequent CT colonography and segmentally unblinded colonoscopy...
October 2011: Radiology
https://www.readbyqxmd.com/read/20939732/differences-in-hiv-burden-and-immune-activation-within-the-gut-of-hiv-positive-patients-receiving-suppressive-antiretroviral-therapy
#19
Steven A Yukl, Sara Gianella, Elizabeth Sinclair, Lorrie Epling, Qingsheng Li, Lijie Duan, Alex L M Choi, Valerie Girling, Terence Ho, Peilin Li, Katsuya Fujimoto, Harry Lampiris, C Bradley Hare, Mark Pandori, Ashley T Haase, Huldrych F Günthard, Marek Fischer, Amandeep K Shergill, Kenneth McQuaid, Diane V Havlir, Joseph K Wong
BACKGROUND: The gut is a major reservoir for human immunodeficiency virus (HIV) in patients receiving antiretroviral therapy (ART). We hypothesized that distinct immune environments within the gut may support varying levels of HIV. METHODS: In 8 HIV-1-positive adults who were receiving ART and had CD4(+) T cell counts of >200 cells/μL and plasma viral loads of <40 copies/mL, levels of HIV and T cell activation were measured in blood samples and endoscopic biopsy specimens from the duodenum, ileum, ascending colon, and rectum...
November 15, 2010: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/20875785/surveillance-guidelines-should-be-updated-to-recognize-the-importance-of-serrated-polyps
#20
EDITORIAL
Jonathan P Terdiman, Kenneth R McQuaid
No abstract text is available yet for this article.
November 2010: Gastroenterology
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