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https://www.readbyqxmd.com/read/29208464/risk-factors-for-postpolypectomy-bleeding-in-patients-receiving-anticoagulation-or-antiplatelet-medications
#1
David Lin, Roy M Soetikno, Kenneth McQuaid, Chi Pham, Gilbert Doan, Shanshan Mou, Amandeep K Shergill, Ma Somsouk, Robert V Rouse, Tonya Kaltenbach
BACKGROUND AND AIMS: Balancing the risks for thromboembolism and postpolypectomy bleeding in patients requiring anticoagulation and antiplatelet agents is challenging. We investigated the incidence and risk factors for postpolypectomy bleeding on anticoagulation, including heparin bridge, and other antithrombotic therapy. METHODS: We performed a retrospective cohort and case control study at 2 tertiary care medical centers from 2004 to 2012. Cases included male patients on antithrombotics with hematochezia after polypectomy...
December 2, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29139082/asge-endovators-summit-defining-the-role-and-value-of-endoscopic-therapies-in-obesity-management
#2
Marvin Ryou, Kenneth R McQuaid, Christopher C Thompson, Steven Edmundowic, Klaus Mergener
No abstract text is available yet for this article.
November 14, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29139029/asge-endovators-summit-defining-the-role-and-value-of-endoscopic-therapies-in-obesity-management
#3
Marvin Ryou, Kenneth R McQuaid, Christopher C Thompson, Steven Edmundowicz, Klaus Mergener
No abstract text is available yet for this article.
November 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29138927/asge-endovators-summit-defining-the-role-and-value-of-endoscopic-therapies-in-obesity-management
#4
Marvin Ryou, Kenneth R McQuaid, Christopher C Thompson, Steven Edmundowicz, Klaus Mergener
No abstract text is available yet for this article.
November 14, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29031371/asge-endovators-summit-defining-the-role-and-value-of-endoscopic-therapies-in-obesity-management
#5
Marvin Ryou, Kenneth R McQuaid, Christopher C Thompson, Steven Edmundowicz, Klaus Mergener, Barham Abu Dayyeh, Caroline Apovian, Carol Burke, Bipan Chand, Anil Chandraker, Thomas Deas, William Dietz, Brian Dunkin, Opella Ernest, Douglas Faigel, Shawn Garber, Osama Hamdy, Lee Kaplan, Nitin Kumar, Robert Kushner, Michael C Larsen, Herbert Lerner, Glenn Littenberg, Christos Mantzoros, Samer Mattar, Rachel Moore, Mary Rinella, Richard Rothstein, Dean Schillinger, Bonnie Spring, Shelby Sullivan, Jeffrey Tice, John Vargo, Erik Wilson, Karen Woods, Natan Zundel
No abstract text is available yet for this article.
November 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29030161/asge-endovators-summit-defining-the-role-and-value-of-endoscopic-therapies-in-obesity-management
#6
Marvin Ryou, Kenneth R McQuaid, Christopher C Thompson, Steven Edmundowicz, Klaus Mergener, Barham Abu Dayyeh, Caroline Apovian, Carol Burke, Bipan Chand, Anil Chandraker, Thomas Deas, William Dietz, Brian Dunkin, Opella Ernest, Douglas Faigel, Shawn Garber, Osama Hamdy, Lee Kaplan, Nitin Kumar, Robert Kushner, Michael C Larsen, Herbert Lerner, Glenn Littenberg, Christos Mantzoros, Samer Mattar, Rachel Moore, Mary Rinella, Richard Rothstein, Dean Schillinger, Bonnie Spring, Shelby Sullivan, Jeffrey Tice, John Vargo, Erik Wilson, Karen Woods, Natan Zundel
No abstract text is available yet for this article.
September 8, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28841650/transparency-ethics-in-practice-revisiting-financial-conflicts-of-interest-disclosure-forms-in-clinical-practice-guidelines
#7
Yidan Lu, Derek J Jones, Nour Sharara, Tonya Kaltenbach, Loren Laine, Kenneth McQuaid, Roy Soetikno, Venkataraman Subramanian, Alan Barkun
BACKGROUND: Authors of clinical practice guidelines (CPGs) disclose financial conflicts of interest (FCOIs) to promote transparency ethics. Typically, they do so on standard declaration forms containing generic open-ended questions on FCOIs. Yet, the literature is scant on the format and effect of alternative disclosure forms. Does supplementing a standard form with subsequent detailed disclosure forms tailored to the context of the CPG improve the yield or accuracy of FCOIs declarations? METHODS: For an international CPG in gastroenterology on the endoscopic surveillance for colorectal neoplasia in inflammatory bowel disease, we compared the use of a standard FCOIs disclosure form with a contextual FCOIs disclosure form that detailed commercial relations related to the CPG topic...
2017: PloS One
https://www.readbyqxmd.com/read/28818507/optimizing-quality-of-endoscopy-in-inflammatory-bowel-disease-focus-on-surveillance-and-management-of-colorectal-dysplasia-using-interactive-image-and-video-based-teaching
#8
Tonya R Kaltenbach, Roy M Soetikno, Rebecca DeVivo, Loren A Laine, Alan Barkun, Kenneth R McQuaid
BACKGROUND & AIMS: Varying recommendations regarding the detection and management of dysplasia can lead to uncertainty and may have impeded the uptake of strategies that could improve surveillance in patients with inflammatory bowel disease (IBD). As such, an educational event was held to assist in disseminating the recently published Surveillance for Colorectal Endoscopic Neoplasia Detection and Management in Inflammatory Bowel Disease Patients: International Consensus Recommendations (SCENIC)...
August 14, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28524155/statin-use-candidate-mevalonate-pathway-biomarkers-and-colon-cancer-survival-in-a-population-based-cohort-study
#9
Ronan T Gray, Maurice B Loughrey, Peter Bankhead, Chris R Cardwell, Stephen McQuaid, Roisin F O'Neill, Kenneth Arthur, Victoria Bingham, Claire McGready, Anna T Gavin, Jacqueline A James, Peter W Hamilton, Manuel Salto-Tellez, Liam J Murray, Helen G Coleman
BACKGROUND: Statin use after colorectal cancer diagnosis may improve survival but evidence from observational studies is conflicting. The anti-cancer effect of statins may be restricted to certain molecular subgroups. In this population-based cohort study, the interaction between p53 and 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGCR) expression, KRAS mutations, and the association between statin use and colon cancer survival was assessed. METHODS: The cohort consisted of 740 stage II and III colon cancer patients diagnosed between 2004 and 2008...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28448072/evaluation-of-ptgs2-expression-pik3ca-mutation-aspirin-use-and-colon-cancer-survival-in-a-population-based-cohort-study
#10
Ronan T Gray, Marie M Cantwell, Helen G Coleman, Maurice B Loughrey, Peter Bankhead, Stephen McQuaid, Roisin F O'Neill, Kenneth Arthur, Victoria Bingham, Claire McGready, Anna T Gavin, Chris R Cardwell, Brian T Johnston, Jacqueline A James, Peter W Hamilton, Manuel Salto-Tellez, Liam J Murray
OBJECTIVES: The association between aspirin use and improved survival after colorectal cancer diagnosis may be more pronounced in tumors that have PIK3CA mutations or high PTGS2 expression. However, the evidence of a difference in association by biomarker status lacks consistency. In this population-based colon cancer cohort study the interaction between these biomarkers, aspirin use, and survival was assessed. METHODS: The cohort consisted of 740 stage II and III colon cancer patients diagnosed between 2004 and 2008...
April 27, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27102531/improving-detection-of-colorectal-dysplasia-in-inflammatory-bowel-disease-surveillance
#11
EDITORIAL
Tonya Kaltenbach, Kenneth R McQuaid, Roy Soetikno, Loren Laine
No abstract text is available yet for this article.
May 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/26866420/paradigm-shift-in-the-surveillance-and-management-of-dysplasia-in-inflammatory-bowel-disease-west
#12
REVIEW
Roy Soetikno, Tonya Kaltenbach, Kenneth R McQuaid, Venkataraman Subramanian, Rahul Kumar, Alan N Barkun, Loren Laine
Patients with long-standing inflammatory bowel disease (IBD) colitis have a 2.4-fold higher risk of developing colorectal cancer (CRC) than the general population, for both ulcerative colitis (UC) and Crohn's disease (CD) colitis. Surveillance colonoscopy is recommended to detect early CRC and dysplasia. Most dysplasia discovered in patients with IBD is actually visible. Recently published SCENIC (Surveillance for Colorectal Endoscopic Neoplasia Detection and Management in Inflammatory Bowel Disease Patients: International Consensus Recommendations) consensus statements provide unifying recommendations for the optimal surveillance and management of dysplasia in IBD...
April 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/26364967/a-roadmap-to-the-implementation-of-chromoendoscopy-in-inflammatory-bowel-disease-colonoscopy-surveillance-practice
#13
Silvia Sanduleanu, Tonya Kaltenbach, Alan Barkun, Robert P McCabe, Fernando Velayos, Michael F Picco, Loren Laine, Roy Soetikno, Kenneth R McQuaid
No abstract text is available yet for this article.
January 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/25936449/protective-association-of-colonoscopy-against-proximal-and-distal-colon-cancer-and-patterns-in-interval-cancer
#14
Amandeep K Shergill, Erin E Conners, Kenneth R McQuaid, Sara Epstein, James C Ryan, Janak N Shah, John Inadomi, Ma Somsouk
BACKGROUND: The protective effect of colonoscopy against proximal colorectal cancer is variable and depends on the detection and complete removal of precancerous polyps. OBJECTIVE: To estimate the efficacy of colonoscopy in a medical center with open-access screening colonoscopy since 1998. DESIGN: Nested case-control study with incidence density sampling. SETTING: University-affiliated Veterans Affairs Medical Center...
September 2015: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/25811360/site-specific-differences-in-t-cell-frequencies-and-phenotypes-in-the-blood-and-gut-of-hiv-uninfected-and-art-treated-hiv-adults
#15
Steven A Yukl, Amandeep K Shergill, Valerie Girling, Qingsheng Li, Maudi Killian, Lorrie Epling, Peilin Li, Philipp Kaiser, Ashley Haase, Diane V Havlir, Kenneth McQuaid, Elizabeth Sinclair, Joseph K Wong
Gastrointestinal T lymphocytes are critical for mucosal immunity and HIV pathogenesis, yet little is known about normal T cell numbers and phenotypes in different regions of the gut, or the degree to which ART can restore levels to those of HIV-uninfected individuals. To investigate these questions, we measured T cell frequencies and markers of memory, activation, anergy, and homing in the blood, ileum, and rectum of HIV- and ART-suppressed HIV+ adults. In HIV- individuals, T cell frequencies and phenotypes differed significantly between sites...
2015: PloS One
https://www.readbyqxmd.com/read/25708752/scenic-international-consensus-statement-on-surveillance-and-management-of-dysplasia-in-inflammatory-bowel-disease
#16
Loren Laine, Tonya Kaltenbach, Alan Barkun, Kenneth R McQuaid, Venkataraman Subramanian, Roy Soetikno
No abstract text is available yet for this article.
March 2015: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/25702852/scenic-international-consensus-statement-on-surveillance-and-management-of-dysplasia-in-inflammatory-bowel-disease
#17
Loren Laine, Tonya Kaltenbach, Alan Barkun, Kenneth R McQuaid, Venkataraman Subramanian, Roy Soetikno
No abstract text is available yet for this article.
March 2015: Gastroenterology
https://www.readbyqxmd.com/read/25387891/real-time-optical-diagnosis-for-diminutive-colorectal-polyps-using-narrow-band-imaging-the-valid-randomised-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Tonya Kaltenbach, Amit Rastogi, Robert V Rouse, Kenneth R McQuaid, Tohru Sato, Ajay Bansal, Jon C Kosek, Roy Soetikno
BACKGROUND: Diminutive (≤ 5 mm) colorectal polyps are common, and overwhelmingly benign. Routinely, after polypectomy, they are examined pathologically to determine the surveillance intervals. Advances in equipment and techniques, such as narrow-band imaging (NBI) colonoscopy, now permit reliable real-time optical diagnosis. METHODS: We conducted a randomised single-masked study involving three institutions to determine whether optical diagnosis of diminutive colorectal polyps meets clinical practice standards and reduces the need for histopathology...
October 2015: Gut
https://www.readbyqxmd.com/read/25264764/endoscopists-can-sustain-high-performance-for-the-optical-diagnosis-of-colorectal-polyps-following-standardized-and-continued-training
#19
RANDOMIZED CONTROLLED TRIAL
Sarah K McGill, Roy Soetikno, Amit Rastogi, Robert V Rouse, Tohru Sato, Ajay Bansal, Kenneth McQuaid, Tonya Kaltenbach
BACKGROUND AND STUDY AIMS: The learning curve for optical diagnosis of colorectal polyps with the narrow-band imaging (NBI) is unknown. To forego histological analysis of diminutive polyps diagnosed optically with high confidence, guidelines recommend ≥ 90 % negative predictive value (NPV) and concordance of ≥ 90 % for surveillance intervals predicted optically and histologically. We aimed to study the learning of optical diagnosis for colorectal polyps. PATIENTS AND METHODS: We studied five endoscopists as part of a randomized multisite trial comparing near-focus and standard-focus views for optical diagnosis...
March 2015: Endoscopy
https://www.readbyqxmd.com/read/25258105/analysis-of-wntless-wls-expression-in-gastric-ovarian-and-breast-cancers-reveals-a-strong-association-with-her2-overexpression
#20
Jonathan Stewart, Jacqueline James, Glenn W McCluggage, Stephen McQuaid, Kenneth Arthur, David Boyle, Paul Mullan, Darragh McArt, Benedict Yan, Gareth Irwin, D Paul Harkin, Lei Zhengdeng, Chee-Wee Ong, Jia Yu, David M Virshup, Manuel Salto-Tellez
The oncogenic role of WNT is well characterized. Wntless (WLS) (also known as GPR177, or Evi), a key modulator of WNT protein secretion, was recently found to be highly overexpressed in malignant astrocytomas. We hypothesized that this molecule may be aberrantly expressed in other cancers known to possess aberrant WNT signaling such as ovarian, gastric, and breast cancers. Immunohistochemical analysis using a TMA platform revealed WLS overexpression in a subset of ovarian, gastric, and breast tumors; this overexpression was associated with poorer clinical outcomes in gastric cancer (P=0...
March 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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