Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Stéphane Lopes-Paciencia, Véronique Bourdeau, Marie-Camille Rowell, Davoud Amirimehr, Jordan Guillon, Paloma Kalegari, Arnab Barua, Vincent Quoc-Huy Trinh, Feryel Azzi, Simon Turcotte, Adrian Serohijos, Gerardo Ferbeyre
We identify a senescence restriction point (SeRP) as a critical event for cells to commit to senescence. The SeRP integrates the intensity and duration of oncogenic stress, keeps a memory of previous stresses, and combines oncogenic signals acting on different pathways by modulating chromatin accessibility. Chromatin regions opened upon commitment to senescence are enriched in nucleolar-associated domains, which are gene-poor regions enriched in repeated sequences. Once committed to senescence, cells no longer depend on the initial stress signal and exhibit a characteristic transcriptome regulated by a transcription factor network that includes ETV4, RUNX1, OCT1, and MAFB...
April 2, 2024: Cell Reports
#2
JOURNAL ARTICLE
Deena Fremont, Rhiannon Roberts, Colleen Webber, Anna E Clarke, Christina Milani, Sarina R Isenberg, Shirley H Bush, Daniel Kobewka, Luke Turcotte, Michelle Howard, Kaitlyn Boese, Amit Arya, Benoit Robert, Aynharan Sinnarajah, Jessica E Simon, Jenny Lau, Danial Qureshi, James Downar, Peter Tanuseputro
OBJECTIVE: To examine changes in the prescribing of end-of-life symptom management medications in long-term care (LTC) homes during the COVID-19 pandemic. DESIGN: Retrospective cohort study using routinely collected health administrative data in Ontario, Canada. SETTING AND PARTICIPANTS: We included all individuals who died in LTC homes between January 1, 2017, and March 31, 2021. We separated the study into 2 periods: before COVID-19 (January 1, 2017, to March 17, 2020) and during COVID-19 (March 18, 2020, to March 31, 2021)...
March 1, 2024: Journal of the American Medical Directors Association
#3
REVIEW
Maaike M E Diesveld, Daniëlle W M Jacobs- Pijnenburg, Rianne A Weersink, Ina Barzel, Joost P H Drenth, Ton Lisman, Herold J Metselaar, Margje H Monster-Simons, Midas B Mulder, Eline Okel, Katja Taxis, Sander D Borgsteede
PURPOSE: The popularity of direct oral anticoagulants (DOACs) is increasing among patients with cirrhosis. Cirrhosis has a major impact on the pharmacokinetics of drugs, potentially increasing adverse events. Safe use of drugs in cirrhosis requires a diligent risk-benefit analysis. The aim of this study is to develop practice recommendations for safe use of DOACs in cirrhosis based on a systematic review of pharmacokinetic, pharmacodynamic and safety data. METHODS: We conducted a systematic literature search to identify studies on pharmacokinetics, pharmacodynamics and safety of DOACs in cirrhosis...
March 2, 2024: European Journal of Clinical Pharmacology
#4
JOURNAL ARTICLE
Palliative End-of-Life Medication Prescribing Rates in Long-Term Care: A Retrospective Cohort Study.
Peter Tanuseputro, Rhiannon Roberts, Christina Milani, Anna E Clarke, Colleen Webber, Sarina R Isenberg, Daniel Kobewka, Luke Turcotte, Shirley H Bush, Kaitlyn Boese, Amit Arya, Benoit Robert, Aynharan Sinnarajah, Jessica E Simon, Michelle Howard, Jenny Lau, Danial Qureshi, Deena Fremont, James Downar
BACKGROUND: Medications are often needed to manage distressing end-of-life symptoms (eg, pain, agitation). OBJECTIVES: In this study, we describe the variation in prescribing rates of symptom relief medications at the end of life among long-term care (LTC) decedents. We evaluate the extent these medications are prescribed in LTC homes and whether prescribing rates of end-of-life symptom management can be used as an indicator of quality end-of-life care. DESIGN: Retrospective cohort study using administrative health data...
January 16, 2024: Journal of the American Medical Directors Association
#5
JOURNAL ARTICLE
Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon-Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan-Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub
Metastatic uveal melanomas are highly resistant to all existing treatments. To address this critical issue, we performed a kinome-wide CRISPR-Cas9 knockout screen, which revealed the LKB1-SIK2 module in restraining uveal melanoma tumorigenesis. Functionally, LKB1 loss enhances proliferation and survival through SIK2 inhibition and upregulation of the sodium/calcium (Na+ /Ca2+ ) exchanger SLC8A1. This signaling cascade promotes increased levels of intracellular calcium and mitochondrial reactive oxygen species, two hallmarks of cancer...
November 15, 2023: EMBO Molecular Medicine
#6
JOURNAL ARTICLE
Gautam Mehta, Antonio Riva, Maria Pilar Ballester, Eva Uson, Montserrat Pujadas, Ângela Carvalho-Gomes, Ivan Sahuco, Ariadna Bono, Federico D'Amico, Raffaela Viganò, Elena Diago, Beatriz Tormo Lanseros, Elvira Inglese, Dani Martinez Vazquez, Rajni Sharma, Hio Lam Phoebe Tsou, Nicola Harris, Annelotte Broekhoven, Marjolein Kikkert, Shessy P Torres Morales, Sebenzile K Myeni, Mar Riveiro-Barciela, Adriana Palom, Nicola Zeni, Alessandra Brocca, Annarosa Cussigh, Sara Cmet, Desamparados Escudero-García, Matteo Stocco, Leonardo Antonio Natola, Donatella Ieluzzi, Veronica Paon, Angelo Sangiovanni, Elisa Farina, Clara di Benedetto, Yolanda Sánchez-Torrijos, Ana Lucena-Varela, Eva Román, Elisabet Sánchez, Rubén Sánchez-Aldehuelo, Julia López-Cardona, Itzel Canas-Perez, Christine Eastgate, Dhaarica Jeyanesan, Alejandro Esquivel Morocho, Simone Di Cola, Lucia Lapenna, Giacomo Zaccherini, Deborah Bongiovanni, Paola Zanaga, Katia Sayaf, Sabir Hossain, Javier Crespo, Mercedes Robles-Díaz, Antonio Madejón, Helena Degroote, Javier Fernández, Marko Korenjak, Xavier Verhelst, Javier García-Samaniego, Raúl J Andrade, Paula Iruzubieta, Gavin Wright, Paolo Caraceni, Manuela Merli, Vishal C Patel, Amir Gander, Agustín Albillos, Germán Soriano, Maria Francesca Donato, David Sacerdoti, Pierluigi Toniutto, Maria Buti, Christophe Duvoux, Paolo Antonio Grossi, Thomas Berg, Wojciech G Polak, Massimo Puoti, Anna Bosch-Comas, Luca Belli, Patrizia Burra, Francesco Paolo Russo, Minneke Coenraad, José Luis Calleja, Giovanni Perricone, Marina Berenguer, Joan Claria, Richard Moreau, Vicente Arroyo, Paolo Angeli, Cristina Sánchez, Javier Ampuero, Salvatore Piano, Shilpa Chokshi, Rajiv Jalan
BACKGROUND: Vaccine hesitancy and lack of access remain major issues in disseminating COVID-19 vaccination to liver patients globally. Factors predicting poor response to vaccination and risk of breakthrough infection are important data to target booster vaccine programs. The primary aim of the current study was to measure humoral responses to 2 doses of COVID-19 vaccine. Secondary aims included the determination of factors predicting breakthrough infection. METHODS: COVID-19 vaccination and Biomarkers in cirrhosis And post-Liver Transplantation is a prospective, multicenter, observational case-control study...
November 1, 2023: Hepatology Communications
#7
JOURNAL ARTICLE
Melanie Berube, Simon Ouellet, Valérie Turcotte, Annick Gagné, Céline Gélinas
Oropharyngeal dysphagia is common in moderate-severe traumatic brain injury (TBI) and cervical spinal cord injury (SCI) patients and can have serious consequences. Delaying feeding in these patients can also be detrimental. Nonetheless, the psychometric properties of screening tools that can promptly identify dysphagia have never been tested in these neurotrauma populations. This study aimed to: 1) adapt, translate and validate the content of the French-Canadian version of the the Standardized Swallowing Assessment (SSA) tool to meet the needs of moderate-severe TBI and cervical SCI patients, 2) examine its interrater reliability and criterion-concurrent validation and 3) evaluate its clinical utility from the perspectives of critical care nurses...
September 19, 2023: Journal of Neurotrauma
#8
JOURNAL ARTICLE
David Henault, David Stephen, Pierre-Antoine St-Hilaire, Nouredin Messaoudi, Franck Vandenbroucke-Menu, Eve Simoneau, Zhixia Rong, Marylène Plasse, Richard Létourneau, André Roy, Michel Dagenais, Réal Lapointe, Bich Nguyen, Anne-Marie Mes-Masson, G Soucy, Simon Turcotte
In colorectal cancer liver metastases (CRLM), the density of tumor-infiltrating lymphocytes, the expression of class I major histocompatibility complex (MHC-I), and the pathological response to preoperative chemotherapy have been associated with oncological outcomes after complete resection. However, the prognostic significance of the heterogeneity of these features in patients with multiple CRLMs remains under investigation. We used a tissue microarray of 220 mismatch repair-gene proficient CRLMs resected in 97 patients followed prospectively to quantify CD3+ T cells and MHC-I by immunohistochemistry...
2023: Oncoimmunology
#9
JOURNAL ARTICLE
Dave Holmes, Pier-Luc Turcotte, Simon Adam, Jim Johansson, Lauren Orser
Traditional health sciences (including nursing) paradigms, conceptual models, and theories have relied heavily upon notions of the 'person' or 'patient' that are deeply rooted in humanistic principles. Our intention here, as a collective academic assemblage, is to question taken-for-granted definitions and assumptions of the 'person' from a critical posthumanist perspective. To do so, the cinematic works of filmmaker David Cronenberg offer a radical perspective to revisit our understanding of the 'person' in nursing and beyond...
September 18, 2023: Nursing Inquiry
#10
JOURNAL ARTICLE
Guidance document: risk assessment of patients with cirrhosis prior to elective non-hepatic surgery.
Nadir Abbas, Jonathan Fallowfield, David Patch, Adrian J Stanley, Raj Mookerjee, Emmanouil Tsochatzis, Joanna A Leithead, Peter Hayes, Abhishek Chauhan, Vikram Sharma, Neil Rajoriya, Simon Bach, Thomas Faulkner, Dhiraj Tripathi
As a result of the increasing incidence of cirrhosis in the UK, more patients with chronic liver disease are being considered for elective non-hepatic surgery. A historical reluctance to offer surgery to such patients stems from general perceptions of poor postoperative outcomes. While this is true for those with decompensated cirrhosis, selected patients with compensated early-stage cirrhosis can have good outcomes after careful risk assessment. Well-recognised risks include those of general anaesthesia, bleeding, infections, impaired wound healing, acute kidney injury and cardiovascular compromise...
2023: Frontline Gastroenterology
#11
JOURNAL ARTICLE
Ralph Saber, David Henault, Nouredin Messaoudi, Rolando Rebolledo, Emmanuel Montagnon, Geneviève Soucy, John Stagg, An Tang, Simon Turcotte, Samuel Kadoury
BACKGROUND: Finding a noninvasive radiomic surrogate of tumor immune features could help identify patients more likely to respond to novel immune checkpoint inhibitors. Particularly, CD73 is an ectonucleotidase that catalyzes the breakdown of extracellular AMP into immunosuppressive adenosine, which can be blocked by therapeutic antibodies. High CD73 expression in colorectal cancer liver metastasis (CRLM) resected with curative intent is associated with early recurrence and shorter patient survival...
July 27, 2023: Journal of Translational Medicine
#12
JOURNAL ARTICLE
Vincent Tambay, Valérie-Ann Raymond, Corentine Goossens, Louise Rousseau, Simon Turcotte, Marc Bilodeau
BACKGROUND: Hepatocellular carcinoma (HCC) is a major contributor to cancer-related morbidity and mortality burdens globally. Given the fundamental metabolic activity of hepatocytes within the liver, hepatocarcinogenesis is bound to be characterized by alterations in metabolite profiles as a manifestation of metabolic reprogramming. METHODS: HCC and adjacent non-tumoral liver specimens were obtained from patients after HCC resection. Global patterns in tissue metabolites were identified using non-targeted 1 H Nuclear Magnetic Resonance (1 H-NMR) spectroscopy whereas specific metabolites were quantified using targeted liquid chromatography-mass spectrometry (LC/MS)...
June 18, 2023: Cancers
#13
JOURNAL ARTICLE
Valérie Turcotte, Carol Hudon, Olivier Potvin, Mahsa Dadar, Simon Duchesne
BACKGROUND: Slowed rates of cognitive decline have been reported in individuals with higher cognitive reserve (CR), but interindividual discrepancies remain unexplained. Few studies have reported a birth cohort effect, favoring later-born individuals, but these studies remain scarce. OBJECTIVE: We aimed to predict cognitive decline in older adults using birth cohorts and CR. METHODS: Within the Alzheimer's Disease Neuroimaging Initiative, 1,041 dementia-free participants were assessed on four cognitive domains (verbal episodic memory; language and semantic memory; attention; executive functions) at each follow-up visit up to 14 years...
March 22, 2023: Journal of Alzheimer's Disease: JAD
#14
JOURNAL ARTICLE
Lydi-Anne Vézina-Im, Dominique Beaulieu, Stéphane Turcotte, Catherine Savard, Simone Lemieux, Danielle Boucher, Maria-Cecilia Gallani, Marie-Claude Paquette
Purpose: To examine the temporal stability and relative validity of the adapted French version of an English self-reported questionnaire measuring the beverage intake (BEVQ) of adolescents. Methods: The French adaptation of the BEVQ (AF-BEVQ) included conversion from the imperial to the metric system and the adjustment of some formats to those available in Canada. Next, 60 adolescents from two regions in Quebec completed the AF-BEVQ and two web-based 24-hour dietary recalls (R24W) (one for a weekday and one for a weekend day) on two occasions, two weeks apart...
March 20, 2023: Canadian Journal of Dietetic Practice and Research
#15
JOURNAL ARTICLE
Célia Jacoberger-Foissac, Isabelle Cousineau, Yacine Bareche, David Allard, Pavel Chrobak, Bertrand Allard, Sandra Pommey, Nouredin Messaoudi, Yannic McNicoll, Geneviève Soucy, Secil Koseoglu, Ricard Masia, Andrew C Lake, Heewon Seo, Christopher B Eeles, Neha Rohatgi, Simon C Robson, Simon Turcotte, Benjamin Haibe-Kains, John Stagg
The ectonucleotidases CD39 and CD73 catalyze extracellular ATP to immunosuppressive adenosine, and as such, represent potential cancer targets. We investigated biological impacts of CD39 and CD73 in pancreatic ductal adenocarcinoma (PDAC) by studying clinical samples and experimental mouse tumors. Stromal CD39 and tumoral CD73 expression significantly associated with worse survival in human PDAC samples and abolished the favorable prognostic impact associated with the presence of tumor-infiltrating CD8+ T cells...
January 3, 2023: Cancer Immunology Research
#16
JOURNAL ARTICLE
Michèle Rouleau, Flora Nguyen Van Long, Véronique Turcotte, Patrick Caron, Louis Lacombe, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Eric Lévesque, Chantal Guillemette
BACKGROUND: Naturally occurring germline gene deletions (KO) represent a unique setting to interrogate gene functions. Complete deletions and differential expression of the human glycosyltransferase UGT2B17 and UGT2B28 genes are linked to prostate cancer (PCa) risk and progression, leukaemia, autoimmune and other diseases. METHODS: The systemic metabolic consequences of UGT deficiencies were examined using untargeted and targeted mass spectrometry-based metabolomics profiling of carefully matched, treatment-naive PCa cases...
November 8, 2022: British Journal of Cancer
#17
JOURNAL ARTICLE
Brian D Griffith, Simon Turcotte, Jenny Lazarus, Fatima Lima, Samantha Bell, Lawrence Delrosario, Jake McGue, Santhoshi Krishnan, Morgan D Oneka, Hari Nathan, J Joshua Smith, Michael I D'Angelica, Jinru Shia, Marina Pasca Di Magliano, Arvind Rao, Timothy L Frankel
Despite advances in therapy over the past decades, metastatic colorectal cancer (mCRC) remains a highly morbid disease. While the impact of MHC-I on immune infiltration in mCRC has been well studied, data on the consequences of MHC-II loss are lacking. Multiplex fluorescent immunohistochemistry (mfIHC) was performed on 149 patients undergoing curative intent resection for mCRC and stratified into high and low human leukocyte antigen isotype DR (HLA-DR) expressing tumors. Intratumoral HLA-DR expression was found in stromal bands, and its expression level was associated with different infiltrating immune cell makeup and distribution...
August 24, 2022: Cancers
#18
JOURNAL ARTICLE
Cyrill Hess, Jonathan M Levine, Martin M Turcotte, Simon P Hart
Ecological explanations for species coexistence assume that species' traits, and therefore the differences between species, are fixed on short timescales. However, species' traits are not fixed, but can instead change rapidly as a consequence of phenotypic plasticity. Here we use a combined experimental-theoretical approach to demonstrate that plasticity in response to interspecific competition between two aquatic plants allows for species coexistence where competitive exclusion is otherwise predicted to occur...
August 4, 2022: Nature Ecology & Evolution
#19
JOURNAL ARTICLE
Marion Tonneau, Alexis Nolin-Lapalme, Suzanne Kazandjian, Edouard Auclin, Justin Panasci, Myriam Benlaifaoui, Mayra Ponce, Afnan Al-Saleh, Wiam Belkaid, Sabrine Naimi, Catalin Mihalcioiu, Ian Watson, Mickael Bouin, Wilson Miller, Marie Hudson, Matthew K Wong, Rossanna C Pezo, Simon Turcotte, Karl Bélanger, Rahima Jamal, Paul Oster, Dominique Velin, Corentin Richard, Meriem Messaoudene, Arielle Elkrief, Bertrand Routy
The microbiome is now regarded as one of the hallmarks of cancer and several strategies to modify the gut microbiota to improve immune checkpoint inhibitor (ICI) activity are being evaluated in clinical trials. Preliminary data regarding the upper gastro-intestinal microbiota indicated that Helicobacter pylori seropositivity was associated with a negative prognosis in patients amenable to ICI. In 97 patients with advanced melanoma treated with ICI, we assessed the impact of H. pylori on outcomes and microbiome composition...
2022: Oncoimmunology
#20
JOURNAL ARTICLE
Turan Aghayev, Aleksandra M Mazitova, Jennifer R Fang, Iuliia O Peshkova, Matthew Rausch, Manhsin Hung, Kerry F White, Ricard Masia, Elizaveta K Titerina, Aliia R Fatkhullina, Isabelle Cousineau, Simon Turcotte, Dmitry Zhigarev, Anastasiia Marchenko, Svetlana Khoziainova, Petr Makhov, Yin Fei Tan, Andrew V Kossenkov, David L Wiest, John Stagg, Xin Wei Wang, Kerry S Campbell, Amiran K Dzutsev, Giorgio Trinchieri, Jonathan A Hill, Sergei I Grivennikov, Ekaterina K Koltsova
UNLABELLED: Although inflammatory mechanisms driving hepatocellular carcinoma (HCC) have been proposed, the regulators of anticancer immunity in HCC remain poorly understood. We found that IL27 receptor (IL27R) signaling promotes HCC development in vivo. High IL27EBI3 cytokine or IL27RA expression correlated with poor prognosis for patients with HCC. Loss of IL27R suppressed HCC in vivo in two different models of hepatocarcinogenesis. Mechanistically, IL27R sig-naling within the tumor microenvironment restrains the cytotoxicity of innate cytotoxic lymphocytes...
August 5, 2022: Cancer Discovery
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
