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Simon turcotte

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https://www.readbyqxmd.com/read/28487614/patients-with-non-viral-liver-disease-have-a-greater-tumor-burden-and-less-curative-treatment-options-when-diagnosed-with-hepatocellular-carcinoma
#1
Waled Mohsen, Marcia Rodov, Emilia Prakoso, Barbara Charlton, David G Bowen, David J Koorey, Nicholas A Shackel, Geoffrey W McCaughan, Simone I Strasser
AIM: To assess the impact of underlying liver disease etiology on the presenting features and outcomes in a large cohort of patients with hepatocellular carcinoma (HCC). METHODS: A prospective database of all patients with HCC was established from 1998 to March 2012. One thousand and seventy-eight patients were categorized into three groups, based on the etiology of their liver disease: hepatitis B virus (HBV), hepatitis C virus (HCV) and non-viral liver disease (NVLD)...
April 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28486780/quantitative-proteomics-to-study-a-small-molecule-targeting-the-loss-of-von-hippel-lindau-in-renal-cell-carcinomas
#2
Nadia Bouhamdani, Andrew Joy, David Barnett, Kevin Cormier, Daniel Léger, Ian C Chute, Simon Lamarre, Rodney Ouellette, Sandra Turcotte
Inactivation of the tumor suppressor gene, von Hippel-Lindau (VHL), is known to play an important role in the development of sporadic clear cell renal cell carcinomas (ccRCCs). Even if available targeted therapies for metastatic RCCs (mRCCs) have helped to improve progression-free survival rates, they have no durable clinical response. We have previously shown the feasibility of specifically targeting the loss of VHL with the identification of a small molecule, STF-62247. Understanding its functionality is crucial for developing durable personalized therapeutic agents differing from those available targeting hypoxia inducible factor (HIF-) pathways...
May 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28422043/real-world-efficacy-and-safety-of-ritonavir-boosted-paritaprevir-ombitasvir-dasabuvir-%C3%A2-ribavirin-for-hepatitis-c-genotype-1-final-results-of-the-rev1tal-study
#3
John Lubel, Simone Strasser, Katherine A Stuart, Gregory Dore, Alexander Thompson, Stephen Pianko, Steven Bollipo, Joanne L Mitchell, Vincenzo Fragomeli, Tracey Jones, Sarah Chivers, Paul Gow, David Iser, Miriam Levy, Edmund Tse, Alessia Gazzola, Wendy Cheng, Saroj Nazareth, Sam Galhenage, Amanda Wade, Martin Weltman, Alan Wigg, Gerry MacQuillan, Joe Sasadeusz, Jacob George, Amany Zekry, Stuart K Roberts
BACKGROUND: Limited data exist on the outcomes of ritonavir-boosted paritaprevir with ombitasvir and dasabuvir (PrOD) ± ribavirin in a real-world setting. The aim of this study was to compare the efficacy and safety of PrOD-based therapy in hepatitis C genotype 1 patients with and without cirrhosis, and to explore pre-treatment factors predictive of sustained viral response (SVR) and serious adverse events (SAEs) on treatment. METHODS: 451 patients with hepatitis C genotype 1 treated in 20 centres across Australia were included...
April 19, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28213791/tumor-associated-macrophage-infiltration-in-colorectal-cancer-liver-metastases-is-associated-with-better-outcome
#4
Michael J Cavnar, Simon Turcotte, Steven C Katz, Deborah Kuk, Mithat Gönen, Jinru Shia, Peter J Allen, Vinod P Balachandran, Michael I D'Angelica, T Peter Kingham, William R Jarnagin, Ronald P DeMatteo
BACKGROUND: Tumor-associated macrophages (TAMs) support growth in most human cancers, with the notable exception of colorectal adenocarcinoma, in which TAM infiltration of primary tumors is correlated with a better outcome. The importance of TAMs in colorectal liver metastases (CLM) is unknown. METHODS: Using a tissue microarray of CLM resected at their institution from 1998 to 2000, the authors quantified immune marker expression by immunohistochemistry (IHC) using Metamorph Image Analysis software...
February 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28026793/a-wireless-semg-based-body-machine-interface-for-assistive-technology-devices
#5
Cheikh Latyr Fall, Gabriel Gagnon-Turcotte, J F Dube, Jean Simon Gagne, Yanick Delisle, Alexandre Campeau-Lecours, Clement Gosselin, Benoit Gosselin
Assistive Technology (AT) tools and appliances are being more and more widely used and developed worldwide to improve the autonomy of people living with disabilities and ease the interaction with their environments. This paper describes an intuitive and wireless surface electromyography (sEMG) based body-machine interface for AT tools. Spinal cord injuries (SCIs) at C5-C8 levels affect patients' arms, forearms, hands and fingers control. Thus, using classical AT control interfaces (keypads, joysticks, etc.) is often difficult or impossible...
December 21, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27378611/a-health-at-every-size-intervention-improves-intuitive-eating-and-diet-quality-in-canadian-women
#6
Elise Carbonneau, Catherine Bégin, Simone Lemieux, Lyne Mongeau, Marie-Claude Paquette, Mylène Turcotte, Marie-Ève Labonté, Véronique Provencher
BACKGROUND & AIMS: Health at Every Size(®) (HAES(®)) interventions focus on healthy lifestyle by promoting behavioral changes related to diet and physical activity while emphasizing self-acceptance and well-being through an empowerment and intuitive approach. The purpose of this study was to investigate the effects of a HAES(®) program on intuitive eating and diet quality in women. METHODS: The HAES(®) intervention, offered by professionals from Health and Social Services Centers in Quebec (Canada), was composed of thirteen 3-h weekly meetings and a 6-h intensive day...
June 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27174990/histone-h3k36-mutations-promote-sarcomagenesis-through-altered-histone-methylation-landscape
#7
Chao Lu, Siddhant U Jain, Dominik Hoelper, Denise Bechet, Rosalynn C Molden, Leili Ran, Devan Murphy, Sriram Venneti, Meera Hameed, Bruce R Pawel, Jay S Wunder, Brendan C Dickson, Stefan M Lundgren, Krupa S Jani, Nicolas De Jay, Simon Papillon-Cavanagh, Irene L Andrulis, Sarah L Sawyer, David Grynspan, Robert E Turcotte, Javad Nadaf, Somayyeh Fahiminiyah, Tom W Muir, Jacek Majewski, Craig B Thompson, Ping Chi, Benjamin A Garcia, C David Allis, Nada Jabado, Peter W Lewis
Several types of pediatric cancers reportedly contain high-frequency missense mutations in histone H3, yet the underlying oncogenic mechanism remains poorly characterized. Here we report that the H3 lysine 36-to-methionine (H3K36M) mutation impairs the differentiation of mesenchymal progenitor cells and generates undifferentiated sarcoma in vivo. H3K36M mutant nucleosomes inhibit the enzymatic activities of several H3K36 methyltransferases. Depleting H3K36 methyltransferases, or expressing an H3K36I mutant that similarly inhibits H3K36 methylation, is sufficient to phenocopy the H3K36M mutation...
May 13, 2016: Science
https://www.readbyqxmd.com/read/26714499/the-dog-prostate-cancer-dpc-1-model-a-reliable-tool-for-molecular-imaging-of-prostate-tumors-and-metastases
#8
Simone Chevalier, Serge Moffett, Eric Turcotte, Murillo Luz, Lyne Chauvette, Vilma Derbekyan, Eleonora Scarlata, Fatima Zouanat, Armen G Aprikian, Maurice Anidjar
BACKGROUND: Clinical applicability of newly discovered reagents for molecular imaging is hampered by the lack of translational models. As the dog prostate cancer (DPC-1) model recapitulates in dogs the natural history of prostate cancer in man, we tested the feasibility of single-photon emission computed tomography (SPECT)/CT imaging in this model using an anti-prostate-specific membrane antigen (PSMA)/17G1 antibody as the radiotracer. METHODS: Immunoblots and immunohistochemistry (IHC) with 17G1 were performed on canine and human prostate cancer cell lines and tissues...
December 2015: EJNMMI Research
https://www.readbyqxmd.com/read/26516200/immunogenicity-of-somatic-mutations-in-human-gastrointestinal-cancers
#9
Eric Tran, Mojgan Ahmadzadeh, Yong-Chen Lu, Alena Gros, Simon Turcotte, Paul F Robbins, Jared J Gartner, Zhili Zheng, Yong F Li, Satyajit Ray, John R Wunderlich, Robert P Somerville, Steven A Rosenberg
It is unknown whether the human immune system frequently mounts a T cell response against mutations expressed by common epithelial cancers. Using a next-generation sequencing approach combined with high-throughput immunologic screening, we demonstrated that tumor-infiltrating lymphocytes (TILs) from 9 out of 10 patients with metastatic gastrointestinal cancers contained CD4(+) and/or CD8(+) T cells that recognized one to three neo-epitopes derived from somatic mutations expressed by the patient's own tumor...
December 11, 2015: Science
https://www.readbyqxmd.com/read/25600439/genetic-evidence-that-intratumoral-t-cell-proliferation-and-activation-are-associated-with-recurrence-and-survival-in-patients-with-resected-colorectal-liver-metastases
#10
Ajay V Maker, Hiromichi Ito, Qianxing Mo, Elliot Weisenberg, Li-Xuan Qin, Simon Turcotte, Shishir Maithel, Jinru Shia, Leslie Blumgart, Yuman Fong, William R Jarnagin, Ronald P DeMatteo, Michael I D'Angelica
Though immune responses correlate with prognosis in primary colorectal cancer, the role of tumor immunity in metastatic disease is less clear. We hypothesized that patient survival and tumor recurrence correlate with transcriptional evidence of lymphocyte proliferation/activation in resected colorectal cancer liver metastases (CRLM). Microarray gene analysis was performed on liver tumor specimens from 96 patients who underwent resection for CRLM. A Cox proportional hazards model identified genes associated with overall survival (OS) and recurrence-free survival (RFS)...
April 2015: Cancer Immunology Research
https://www.readbyqxmd.com/read/25018069/optimal-pancreatic-phase-delay-with-64-detector-ct-scanner-and-bolus-tracking-technique
#11
RANDOMIZED CONTROLLED TRIAL
An Tang, Jean-Sébastien Billiard, David-Olivier Chagnon, Fadi Rizk, Damien Olivié, Simon Turcotte, Miguel Chagnon, Luigi Lepanto
RATIONALE AND OBJECTIVES: To assess the optimal pancreatic phase delay in terms of parenchymal enhancement and tumor-to-pancreas contrast with a bolus-tracking method. MATERIALS AND METHODS: Patients referred for suspicion of pancreatic tumor and undergoing 64-detector computed tomography scanner were randomized to an individualized scan delay of 10, 20, or 30 seconds of nonionic contrast material (370 mg I/mL) after aortic enhancement above 150 Hounsfield units...
August 2014: Academic Radiology
https://www.readbyqxmd.com/read/24894090/tumor-mhc-class-i-expression-improves-the-prognostic-value-of-t-cell-density-in-resected-colorectal-liver-metastases
#12
Simon Turcotte, Steven C Katz, Jinru Shia, William R Jarnagin, T Peter Kingham, Peter J Allen, Yuman Fong, Michael I D'Angelica, Ronald P DeMatteo
Tumor-infiltrating lymphocytes (TIL) in colorectal cancer liver metastases (CLM) have been associated with more favorable patient outcomes, but whether MHC class I (MHC-I) expression on cancer cells affects prognosis is uncertain. Immunohistochemistry was performed on a tissue microarray of 158 patients with CLM, who underwent partial hepatectomy with curative intent. Using the antibody HC-10, which detects HLA-B and HLA-C antigens and a minority of HLA-A antigens, MHC-I expression was correlated with β-2 microglobulin (β2m; r = 0...
June 2014: Cancer Immunology Research
https://www.readbyqxmd.com/read/24812403/cancer-immunotherapy-based-on-mutation-specific-cd4-t-cells-in-a-patient-with-epithelial-cancer
#13
Eric Tran, Simon Turcotte, Alena Gros, Paul F Robbins, Yong-Chen Lu, Mark E Dudley, John R Wunderlich, Robert P Somerville, Katherine Hogan, Christian S Hinrichs, Maria R Parkhurst, James C Yang, Steven A Rosenberg
Limited evidence exists that humans mount a mutation-specific T cell response to epithelial cancers. We used a whole-exomic-sequencing-based approach to demonstrate that tumor-infiltrating lymphocytes (TIL) from a patient with metastatic cholangiocarcinoma contained CD4+ T helper 1 (T(H)1) cells recognizing a mutation in erbb2 interacting protein (ERBB2IP) expressed by the cancer. After adoptive transfer of TIL containing about 25% mutation-specific polyfunctional T(H)1 cells, the patient achieved a decrease in target lesions with prolonged stabilization of disease...
May 9, 2014: Science
https://www.readbyqxmd.com/read/24667641/pd-1-identifies-the-patient-specific-cd8%C3%A2-%C2%BA-tumor-reactive-repertoire-infiltrating-human-tumors
#14
Alena Gros, Paul F Robbins, Xin Yao, Yong F Li, Simon Turcotte, Eric Tran, John R Wunderlich, Arnold Mixon, Shawn Farid, Mark E Dudley, Ken-Ichi Hanada, Jorge R Almeida, Sam Darko, Daniel C Douek, James C Yang, Steven A Rosenberg
Adoptive transfer of tumor-infiltrating lymphocytes (TILs) can mediate regression of metastatic melanoma; however, TILs are a heterogeneous population, and there are no effective markers to specifically identify and select the repertoire of tumor-reactive and mutation-specific CD8⁺ lymphocytes. The lack of biomarkers limits the ability to study these cells and develop strategies to enhance clinical efficacy and extend this therapy to other malignancies. Here, we evaluated unique phenotypic traits of CD8⁺ TILs and TCR β chain (TCRβ) clonotypic frequency in melanoma tumors to identify patient-specific repertoires of tumor-reactive CD8⁺ lymphocytes...
May 2014: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/24360219/consumption-of-chocolate-in-pregnant-women-and-risk-of-preeclampsia-a-systematic-review
#15
Jaime Andres Mogollon, Catherine Boivin, Kadhel Philippe, Stéphane Turcotte, Simone Lemieux, Claudine Blanchet, Emmanuel Bujold, Sylvie Dodin
BACKGROUND: Previous studies have been limited in reporting the association between chocolate consumption, measured by interviewer-administered questionnaire or serum theobromine, a biomarker for cocoa, and risk of preeclampsia, and have showed somewhat conflicting results. METHODS/DESIGN: A systematic review of observational and experimental studies will be carried out. We will examine PubMed, Embase, and the entire Cochrane Library. Studies of chocolate consumption compared or not with placebo or low flavanol chocolate during pregnancy will be evaluated to investigate the effect of chocolate consumption in pregnant women on the risk of preeclampsia or pregnancy-induced hypertension...
2013: Systematic Reviews
https://www.readbyqxmd.com/read/24319509/canadian-guideline-on-genetic-screening-for-hereditary-renal-cell-cancers
#16
M Neil Reaume, Gail E Graham, Eva Tomiak, Suzanne Kamel-Reid, Michael A S Jewett, Georg A Bjarnason, Normand Blais, Melanie Care, Darryl Drachenberg, Craig Gedye, Ronald Grant, Daniel Y C Heng, Anil Kapoor, Christian Kollmannsberger, Jean-Baptiste Lattouf, Eamonn R Maher, Arnim Pause, Dean Ruether, Denis Soulieres, Simon Tanguay, Sandra Turcotte, Philippe D Violette, Lori Wood, Joan Basiuk, Stephen E Pautler
BACKGROUND: Hereditary renal cell cancer (RCC) is an ideal model for germline genetic testing. We propose a guideline of hereditary RCC specific criteria to suggest referral for genetic assessment. METHODS: A review of the literature and stakeholder resources for existing guidelines or consensus statements was performed. Referral criteria were developed by expert consensus. RESULTS: The criteria included characteristics for patients with RCC (age ≤45 years, bilateral or multifocal tumours, associated medical conditions and non-clear cell histologies with unusual features) and for patients with or without RCC, but a family history of specific clinical or genetic diagnoses...
September 2013: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/24218514/tumor-reactive-cd8-t-cells-in-metastatic-gastrointestinal-cancer-refractory-to-chemotherapy
#17
Simon Turcotte, Alena Gros, Eric Tran, Chyi-Chia R Lee, John R Wunderlich, Paul F Robbins, Steven A Rosenberg
PURPOSE: To evaluate whether patients with metastatic gastrointestinal adenocarcinomas refractory to chemotherapy harbor tumor-reactive cytotoxic T cells. EXPERIMENTAL DESIGN: Expansion of CD8(+) tumor-infiltrating lymphocytes (TIL) and cancer cell lines was attempted from gastrointestinal cancer metastases in 16 consecutive patients for the study of antitumor immune recognition. Retroviral transduction of genes encoding T-cell receptors (TCR) was used to define HLA-restriction elements and specific reactivity...
January 15, 2014: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/23904171/phenotype-and-function-of-t-cells-infiltrating-visceral-metastases-from-gastrointestinal-cancers-and-melanoma-implications-for-adoptive-cell-transfer-therapy
#18
Simon Turcotte, Alena Gros, Katherine Hogan, Eric Tran, Christian S Hinrichs, John R Wunderlich, Mark E Dudley, Steven A Rosenberg
Adoptive cell transfer of tumor-infiltrating lymphocytes (TILs) can mediate cancer regression in patients with metastatic melanoma, but whether this approach can be applied to common epithelial malignancies remains unclear. In this study, we compared the phenotype and function of TILs derived from liver and lung metastases from patients with gastrointestinal (GI) cancers (n = 14) or melanoma (n = 42). Fewer CD3(+) T cells were found to infiltrate GI compared with melanoma metastases, but the proportions of CD8(+) cells, T cell differentiation stage, and expression of costimulatory molecules were similar for both tumor types...
September 1, 2013: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/23578750/the-effect-of-fluid-overload-in-the-presence-of-an-epidural-on-the-strength-of-colonic-anastomoses
#19
Carolyn Nessim, Lucas Sidéris, Simon Turcotte, Petros Vafiadis, Annie-Claude Lapostole, Stéphanie Simard, Patricia Koch, Louis-Philippe Fortier, Pierre Dubé
BACKGROUND: Despite the beneficial effects of epidurals in intra-abdominal surgery, the incidence of anastomotic leak remains controversial when used. Moreover, studies have also shown that fluid overload may be deleterious to anastomoses. The purpose of this paper is to evaluate the effects of varying intraoperative fluid protocols, in the presence of an epidural, on the burst pressure strength of colonic anastomoses. METHODS: An epidural was installed in 18 rabbits, divided into three groups...
August 2013: Journal of Surgical Research
https://www.readbyqxmd.com/read/23108126/resection-versus-transplantation-for-early-hepatocellular-carcinoma-more-art-than-science
#20
EDITORIAL
Simon Turcotte, Ronald P Dematteo
No abstract text is available yet for this article.
December 2012: Annals of Surgery
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