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https://www.readbyqxmd.com/read/28227763/network-effects-and-pathways-in-deep-brain-stimulation-in-parkinson-s-disease
#1
N Koirala, V Fleischer, O Granert, G Deuschl, M Muthuraman, S Groppa, N Koirala, V Fleischer, O Granert, G Deuschl, M Muthuraman, S Groppa
Deep brain stimulation of subthalamic nucleus (STN-DBS) became a standard therapeutic option in Parkinson's disease (PD), even though the underlying modulated network of STN-DBS is still poorly described. Probabilistic tractography and connectivity analysis as derived from diffusion tensor imaging (DTI) were performed together with modelling of implanted electrode positions and linked postoperative clinical outcome. Fifteen patients with idiopathic PD without dementia were selected for DBS treatment. After pre-processing, probabilistic tractography was run from cortical and subcortical seeds of the hypothesized network to targets represented by the positions of the active DBS contacts...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226674/a-multiple-kernel-learning-approach-for-human-behavioral-task-classification-using-stn-lfp-signal
#2
Hosein M Golshan, Adam O Hebb, Sara J Hanrahan, Joshua Nedrud, Mohammad H Mahoor, Hosein M Golshan, Adam O Hebb, Sara J Hanrahan, Joshua Nedrud, Mohammad H Mahoor, Joshua Nedrud, Adam O Hebb, Sara J Hanrahan, Mohammad H Mahoor, Hosein M Golshan
Deep Brain Stimulation (DBS) has gained increasing attention as an effective method to mitigate Parkinson's disease (PD) disorders. Existing DBS systems are open-loop such that the system parameters are not adjusted automatically based on patient's behavior. Classification of human behavior is an important step in the design of the next generation of DBS systems that are closed-loop. This paper presents a classification approach to recognize such behavioral tasks using the subthalamic nucleus (STN) Local Field Potential (LFP) signals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226449/comparison-of-imaging-modalities-and-source-localization-algorithms-in-locating-the-induced-activity-during-deep-brain-stimulation-of-the-stn
#3
K G Mideksa, A Singh, N Hoogenboom, H Hellriegel, H Krause, A Schnitzler, G Deuschl, J Raethjen, G Schmidt, M Muthuraman, K G Mideksa, A Singh, N Hoogenboom, H Hellriegel, H Krause, A Schnitzler, G Deuschl, J Raethjen, G Schmidt, M Muthuraman, G Deuschl, K G Mideksa, A Singh, H Krause, A Schnitzler, N Hoogenboom, M Muthuraman, J Raethjen, G Schmidt, H Hellriegel
One of the most commonly used therapy to treat patients with Parkinson's disease (PD) is deep brain stimulation (DBS) of the subthalamic nucleus (STN). Identifying the most optimal target area for the placement of the DBS electrodes have become one of the intensive research area. In this study, the first aim is to investigate the capabilities of different source-analysis techniques in detecting deep sources located at the sub-cortical level and validating it using the a-priori information about the location of the source, that is, the STN...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28218390/lattice-constant-measurement-from-electron-backscatter-diffraction-patterns
#4
N Saowadee, K Agersted, J R Bowen
Kikuchi bands in election backscattered diffraction patterns (EBSP) contain information about lattice constants of crystallographic samples that can be extracted via the Bragg equation. An advantage of lattice constant measurement from EBSPs over diffraction (XRD) is the ability to perform local analysis. In this study, lattice constants of cubic STN and cubic YSZ in the pure materials and in co-sintered composites were measured from their EBSPs acquired at 10 kV using a silicon single crystal as a calibration reference...
February 20, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28211850/subthalamic-neurons-encode-both-single-and-multi-limb-movements-in-parkinson-s-disease-patients
#5
Ariel Tankus, Ido Strauss, Tanya Gurevich, Anat Mirelman, Nir Giladi, Itzhak Fried, Jeffrey M Hausdorff
The subthalamic nucleus (STN) is the main target for neurosurgical treatment of motor signs of Parkinson's disease (PD). Despite the therapeutic effect on both upper and lower extremities, its role in motor control and coordination and its changes in Parkinson's disease are not fully clear. We intraoperatively recorded single unit activity in ten patients with PD who performed repetitive feet or hand movements while undergoing implantation of a deep brain stimulator. We found both distinct and overlapping representations of upper and lower extremity movement kinematics in subthalamic units and observed evidence for re-routing to a multi-limb representation that participates in limb coordination...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28208864/study-of-immunohistochemical-markers-ck-19-cd-56-ki-67-p53-in-differentiating-benign-and-malignant-solitary-thyroid-nodules-with-special-reference-to-papillary-thyroid-carcinomas
#6
Smriti Sudhanshu Dwivedi, Siddhi Gaurish Sinai Khandeparkar, Avinash R Joshi, Maithili Mandar Kulkarni, Pallavi Bhayekar, Amruta Jadhav, Musphera Nayar, Neelam S Kambale
INTRODUCTION: Solitary Thyroid Nodule (STN) has provoked increased concern owing to higher incidence of malignancy. The inter and intra observer variation in the histomorphological diagnosis of Papillary Thyroid Carcinomas (PTC) may sometimes pose a diagnostic difficulty. AIM: This study was undertaken to analyse immunohistochemical (IHC) markers (CK-19, CD-56, p53, Ki-67) to differentiate between benign and malignant surgically resected STN along with their utility in the identification of PTC...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28195591/correction-synthesis-and-immunological-evaluation-of-muc1-glycopeptide-conjugates-bearing-n-acetyl-modified-stn-derivatives-as-anticancer-vaccines
#7
An Xiao, Xiu-Jing Zheng, Chengcheng Song, Yue Gui, Chang-Xin Huo, Xin-Shan Ye
Correction for 'Synthesis and immunological evaluation of MUC1 glycopeptide conjugates bearing N-acetyl modified STn derivatives as anticancer vaccines' by An Xiao et al., Org. Biomol. Chem., 2016, 14, 7226-7237.
February 14, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28192762/neural-mass-models-describing-possible-origin-of-the-excessive-beta-oscillations-correlated-with-parkinsonian-state
#8
Chen Liu, Yulin Zhu, Fei Liu, Jiang Wang, Huiyan Li, Bin Deng, Chris Fietkiewicz, Kenneth A Loparo
In Parkinson's disease, the enhanced beta rhythm is closely associated with akinesia/bradykinesia and rigidity. An increase in beta oscillations (12-35 Hz) within the basal ganglia (BG) nuclei does not proliferate throughout the cortico-basal ganglia loop in uniform fashion; rather it can be subdivided into two distinct frequency bands, i.e. the lower beta (12-20 Hz) and upper beta (21-35 Hz). A computational model of the excitatory and inhibitory neural network that focuses on the population properties is proposed to explore the mechanism underlying the pathological beta oscillations...
January 30, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28176003/assessment-of-individual-cognitive-changes-after-deep-brain-stimulation-surgery-in-parkinson-s-disease-using-the-neuropsychological-test-battery-vienna-short-version
#9
Thomas Foki, Daniela Hitzl, Walter Pirker, Klaus Novak, Gisela Pusswald, Eduard Auff, Johann Lehrner
Long-term therapy of Parkinson's disease with L‑DOPA is associated with a high risk of developing motor fluctuations and dyskinesia. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can improve these motor complications. Although the positive effect on motor symptoms has been proven, postoperative cognitive decline has been documented. To tackle the impact of DBS on cognition, 18 DBS patients were compared to 25 best medically treated Parkinson's patients, 24 patients with mild cognitive impairment (MCI) and 12 healthy controls using the Neuropsychological Test Battery Vienna short version (NTBV-short) for cognitive outcome 12 months after the first examination...
February 7, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28174244/a-novel-floor-plate-boundary-defined-by-adjacent-en1-and-dbx1-microdomains-distinguishes-midbrain-dopamine-and-hypothalamic-neurons
#10
Navid Nouri, Rajeshwar Awatramani
The mesodiencephalic floor plate (mdFP) is the source of diverse neuron types. Yet, how this structure is compartmentalized has not been clearly elucidated. Here, we identify a novel boundary subdividing the mdFP into two microdomains, defined by Engrailed 1 (En1) and developing brain homeobox 1 (Dbx1) Utilizing simultaneous dual and intersectional fate mapping, we demonstrate that this boundary is precisely formed with minimal overlap between En1 and Dbx1 microdomains, unlike many other boundaries. We show that the En1 microdomain gives rise to dopaminergic (DA) neurons, while the Dbx1 microdomain gives rise to subthalamic (STN), premammillary (PM), and posterior hypothalamic (PH) populations...
February 7, 2017: Development
https://www.readbyqxmd.com/read/28164377/disentangling-the-mechanisms-of-cognitive-changes-after-stn-dbs-a-step-forward
#11
EDITORIAL
Karsten Witt
No abstract text is available yet for this article.
February 6, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28159857/glycosylation-is-a-global-target-for-androgen-control-in-prostate-cancer-cells
#12
Jennifer Munkley
Changes in glycan composition are common in cancer and can play important roles in all of the recognised hallmarks of cancer. We recently identified glycosylation as a global target for androgen control in prostate cancer cells and further defined a set of 8 glycosylation enzymes (GALNT7, ST6GalNAc1, GCNT1, UAP1, PGM3, CSGALNACT1, ST6GAL1 and EDEM3), which are also significantly up-regulated in prostate cancer tissue. These 8 enzymes are under direct control of the androgen receptor (AR) and are linked to the synthesis of important cancer-associated glycans such as sialyl-Tn (sTn), sialyl LewisX (SLeX), O-GlcNAc and chondroitin sulphate...
February 3, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28159574/subthalamic-nucleus-deep-brain-stimulation-on-motor-symptoms-of-parkinson-s-disease-focus-on-neurochemistry
#13
REVIEW
A Stefani, V Trendavilof, C Liguori, E Fedele, S Galati
Deep brain stimulation (DBS) has become a standard therapy for Parkinson's disease (PD) and it is also currently under investigation for other neurological and psychiatric disorders. Although many scientific, clinical and ethical issues are still unresolved, DBS delivered into the subthalamic nucleus (STN) has improved the quality of life of several thousands of patients. The mechanisms underlying STN-DBS have been debated extensively in several reviews; less investigated are the biochemical consequences, which are still under scrutiny...
January 31, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28159306/source-apportionment-of-pm2-5-in-baton-rouge-louisiana-during-2009-2014
#14
Fenglin Han, Sri Harsha Kota, Yungang Wang, Hongliang Zhang
Particulate matter with aerodynamic diameter <2.5μm (PM2.5) chemical composition data from the Speciation Trends Network (STN) site located in Baton Rouge, Louisiana were analyzed using the receptor Positive Matrix Factorization (PMF) model version 5.0. The PM2.5 samples were collected every third day from January 2009 to December 2014. Seven sources were identified, including secondary sulfate, secondary nitrate, industrial emissions, traffic, crustal dust, road dust and sea salt. The contributions of these seven sources to PM2...
January 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28157107/the-cross-sectional-area-of-paraspinal-muscles-predicts-the-efficacy-of-deep-drain-stimulation-for-camptocormia
#15
Waka Sakai, Shunya Nakane, Eiichirou Urasaki, Keisuke Toyoda, Eisaku Sadakata, Akiko Nagaishi, Takayasu Fukudome, Yuzo Yamakawa, Hidenori Matsuo
BACKGROUND: Camptocormia, a disturbance of posture, is a well-described clinical feature of PD and other parkinsonian syndromes. Previous reports have shown that DBS of the subthalamic nucleus (STN) or globus pallidus internus is effective in treating camptocormia. However, the efficacy of DBS for camptocormia varies. OBJECTIVE: To determine a clinical marker for selecting an appropriate therapy for camptocormia, a disabling manifestation of Parkinson's disease (PD) that has a variable response to systemic and local therapies...
January 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28156048/targeted-o-glycoproteomics-explored-increased-sialylation-and-identified-muc16-as-a-poor-prognosis-biomarker-in-advanced-stage-bladder-tumours
#16
Sofia Cotton, Rita Azevedo, Cristiana Gaiteiro, Dylan Ferreira, Luís Lima, Andreia Peixoto, Elisabete Fernandes, Manuel Neves, Diogo Neves, Teresina Amaro, Ricardo Cruz, Ana Tavares, Maria Rangel, André M N Silva, Lúcio Lara Santos, José Alexandre Ferreira
Bladder carcinogenesis and tumour progression is accompanied by profound alterations in protein glycosylation on the cell surface, which may be explored for improving disease management. In a search for prognosis biomarkers and novel therapeutic targets we have screened, using immunohistochemistry, a series of bladder tumours with differing clinicopathology for short-chain O-glycans commonly found in glycoproteins of human solid tumours. These included the Tn and T antigens and their sialylated counterparts sialyl-Tn(STn) and sialyl-T(ST), which are generally associated with poor prognosis...
February 3, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28154341/predictive-factors-for-long-term-outcome-of-subthalamic-nucleus-deep-brain-stimulation-for-parkinson-s-disease
#17
Chikashi Fukaya, Mitsuru Watanabe, Kazutaka Kobayashi, Hideki Oshima, Atsuo Yoshino, Takamitsu Yamamoto
Despite the recognition of the usefulness of subthalamic nucleus deep brain stimulation (STN-DBS) for the treatment of Parkinson's disease (PD), preoperative predictive factors for the long-term outcome of STN-DBS are not sufficiently established. We performed this study to determine such predictive factors. The subjects were 66 patients who were classified into two groups on the basis of their activities of daily living (ADL) evaluated five years after the STN-DBS surgery: 33 patients were assigned to the independent ADL group (group I) and the remaining 33 patients to the dependent ADL group (group D)...
January 31, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28137358/distinct-mechanisms-mediate-speed-accuracy-adjustments-in-cortico-subthalamic-networks
#18
Damian M Herz, Huiling Tan, John-Stuart Brittain, Petra Fischer, Binith Cheeran, Alexander L Green, James FitzGerald, Tipu Z Aziz, Keyoumars Ashkan, Simon Little, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Rafal Bogacz, Peter Brown
Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates of such speed-accuracy adjustments by recording subthalamic nucleus (STN) activity and electroencephalography in 11 Parkinson's disease patients during a perceptual decision-making task; STN low-frequency oscillatory (LFO) activity (2-8 Hz), coupled to activity at prefrontal electrode Fz, and STN beta activity (13-30 Hz) coupled to electrodes C3/C4 close to motor cortex...
January 31, 2017: ELife
https://www.readbyqxmd.com/read/28132061/the-effects-of-dexmedetomidine-on-microelectrode-recordings-of-the-subthalamic-nucleus-during-deep-brain-stimulation-surgery-a-retrospective-analysis
#19
Letha Mathews, Corrie R Camalier, Koffi M Kla, Martina D Mitchell, Peter E Konrad, Joseph S Neimat, Kenneth G Smithson
BACKGROUND: The placement of subthalamic nucleus (STN) deep brain stimulation (DBS) electrodes can be facilitated by intraoperative microelectrode recording (MER) of the STN. OBJECTIVES: Optimal anesthetic management during surgery remains unclear because of a lack of quantitative data of the effect of anesthetics on MER. Therefore, we measured the effects of dexmedetomidine (DEX) on MER measures of the STN commonly taken intraoperatively. METHODS: MER from 45 patients was retrospectively compared between patients treated with remifentanil (REMI) alone or both REMI and DEX, which are the 2 main standards of care at our center...
January 28, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28130916/the-human-subthalamic-nucleus-and-globus-pallidus-internus-differentially-encode-reward-during-action-control
#20
Peter Justin Rossi, Corinna Peden, Oscar Castellanos, Kelly D Foote, Aysegul Gunduz, Michael S Okun
The subthalamic nucleus (STN) and globus pallidus internus (GPi) have recently been shown to encode reward, but few studies have been performed in humans. We investigated STN and GPi encoding of reward and loss (i.e., valence) in humans with Parkinson's disease. To test the hypothesis that STN and GPi neurons would change their firing rate in response to reward- and loss-related stimuli, we recorded the activity of individual neurons while participants performed a behavioral task. In the task, action choices were associated with potential rewarding, punitive, or neutral outcomes...
January 28, 2017: Human Brain Mapping
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