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https://www.readbyqxmd.com/read/29126889/impaired-glutamatergic-projection-from-the-motor-cortex-to-the-subthalamic-nucleus-in-6-hydroxydopamine-lesioned-hemi-parkinsonian-rats
#1
Yan-Yan Wang, Yong Wang, Hai-Fei Jiang, Jun-Hua Liu, Jun Jia, Ke Wang, Fei Zhao, Min-Hua Luo, Min-Min Luo, Xiao-Min Wang
The glutamatergic projection from the motor cortex to the subthalamic nucleus (STN) constitutes the cortico-basal ganglia circuit and plays a critical role in the control of movement. Emerging evidence shows that the cortico-STN pathway is susceptible to dopamine depletion. Specifically in Parkinson's disease (PD), abnormal electrophysiological activities were observed in the motor cortex and STN, while the STN serves as a key target of deep brain stimulation for PD therapy. However, direct morphological changes in the cortico-STN connectivity in response to PD progress are poorly understood at present...
November 8, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29125966/stopping-and-slowing-manual-and-spoken-responses-similar-oscillatory-signatures-recorded-from-the-subthalamic-nucleus
#2
Ayda Ghahremani, Jan R Wessel, Kaviraja Udupa, Bogdan Neagu, Ping Zhuang, Utpal Saha, Suneil K Kalia, Mojgan Hodaie, Andres M Lozano, Adam R Aron, Robert Chen
Response control in the forms of stopping and slowing responses is thought to be implemented by a frontal-subcortical network, which includes the subthalamic nucleus (STN). For manual control, stopping is linked to STN beta (13-30 Hz) and slowing responses are linked to lower frequencies (<12 Hz). Whether similar STN oscillatory activities are associated with the control of spoken responses is not clear. We studied 16 patients with STN LFP recordings during manual and vocal stop signal tasks in two experiments...
November 7, 2017: Brain and Language
https://www.readbyqxmd.com/read/29114364/outcome-of-subthalamic-nucleus-deep-brain-stimulation-on-long-term-motor-function-of-patients-with-advanced-parkinson-disease
#3
Gholam Ali Shahidi, Mohammad Rohani, Mansour Parvaresh, Bahram Haghi-Ashtiani, Maryam Saeedi, Romina Rashedi, Zeynab Noori-Motlagh
Background: The objective of our study was to assess Unified Parkinson Disease Rating Scale (UPDRS) score in Parkinson disease (PD) patients who underwent subthalamic nucleus (STN) deep brain stimulation (DBS) 6 years after their surgery and to compare their UPDRS score 6 years after DBS with their score before surgery and 6 months after their operation. Methods: In this cross sectional study which was carried out at Neurology Department of Rasool-e Akram Hospital, Tehran, Iran, affiliated to Iran University of Medical Sciences between 2008 and 2014, 37 patients with advanced PD were enrolled using non-randomized sampling method...
July 6, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/29113860/dramatic-psychiatric-and-behavioral-symptoms-following-a-subthalamic-lesion
#4
Byung Sun Choi, Guangxun Shen, Guangxian Nan, Jong-Min Kim, Ki-Young Jung, Beomseok Jeon
Neuropsychiatric symptoms have been well documented after subthalamic nucleus deep brain stimulation (STN-DBS), but those following a subthalamic lesion have been rarely reported. Herein, we present a 43-year-old woman with sudden-onset dramatic psychiatric and behavioral symptoms with hemiballism. Brain magnetic resonance imaging (MRI) with fluid attenuated inversion recovery (FLAIR) sequence during the acute phase demonstrated extensive hyperintensity in the left STN and adjacent regions. Contrast-enhanced MRI showed no abnormal areas of enhancement...
November 4, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29108390/high-truncated-o-glycan-score-predicts-adverse-clinical-outcome-in-patients-with-localized-clear-cell-renal-cell-carcinoma-after-surgery
#5
SonTung NguyenHoang, Yidong Liu, Le Xu, Lin Zhou, Yuan Chang, Qiang Fu, Zheng Liu, Zongming Lin, Jiejie Xu
Truncated O-glycans, including Tn-antigen, sTn-antigen, T-antigen, sT-antigen, are incomplete glycosylated structures and their expression occur frequently in tumor tissue. The study aims to evaluate the abundance of each truncated O-glycans and its clinical significance in postoperative patients with localized clear-cell renal cell carcinoma (ccRCC). We used immunohistochemical testing to analyze the expression of truncated O-glycans in tumor specimens from 401 patients with localized ccRCC. Truncated-O-glycan score was built by integrating the expression level of Tn-, sTn- and sT-antigen...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098450/early-detection-of-speech-and-voice-disorders-in-parkinson-s-disease-patients-treated-with-subthalamic-nucleus-deep-brain-stimulation-a-1-year-follow-up-study
#6
Takashi Tsuboi, Hirohisa Watanabe, Yasuhiro Tanaka, Reiko Ohdake, Makoto Hattori, Kazuya Kawabata, Kazuhiro Hara, Mizuki Ito, Yasushi Fujimoto, Daisuke Nakatsubo, Satoshi Maesawa, Yasukazu Kajita, Masahisa Katsuno, Gen Sobue
We previously reported that Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS) had distinct phenotypes of speech and voice disorders: hypokinetic dysarthria, stuttering, breathy voice, strained voice, and spastic dysarthria. However, changes over time remain unclear. In the present study, 32 consecutive PD patients were assessed before and up to 1 year after surgery (PD-DBS). Eleven medically treated PD patients were also assessed (PD-Med). Speech, voice, motor, and cognitive functions were evaluated...
November 2, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29089942/the-possible-influence-of-non-synonymous-point-mutations-within-the-fima-adhesin-of-non-typhoidal-salmonella-nts-isolates-in-the-process-of-host-adaptation
#7
Sahar Alshalchi, Shivdeep S Hayer, Ran An, Jeannette Munoz-Aguayo, Christian Flores-Figueroa, Ryan Nguyen, Dale Lauer, Karen Olsen, Julio Alvarez, David Boxrud, Carol Cardona, Sinisa Vidovic
Non-typhoidal Salmonella (NTS) remains a global pathogen that affects a wide range of animal species. We analyzed a large number of NTS isolates of different host origins, including Salmonella Heidelberg (n = 80, avian), S. Dublin (50, bovine), S. Typhimurium var 5- (n = 40, porcine), S. 4,5,12,:i:- (n = 40, porcine), S. Cerro (n = 16, bovine), and S. Montevideo (n = 14, bovine), using virulence profiling of the bcfC, mgtC, ssaC, invE, pefA, stn, sopB, and siiE virulence-associated genes, a biofilm production assay, pulsed field gel electrophoresis, and the full-length sequencing of the fimA (adhesin) and iroN (receptor) genes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29089922/effects-of-subthalamic-and-nigral-stimulation-on-gait-kinematics-in-parkinson-s-disease
#8
Marlieke Scholten, Johannes Klemt, Melanie Heilbronn, Christian Plewnia, Bastiaan R Bloem, Friedemann Bunjes, Rejko Krüger, Alireza Gharabaghi, Daniel Weiss
Conventional subthalamic deep brain stimulation for Parkinson's disease (PD) presumably modulates the spatial component of gait. However, temporal dysregulation of gait is one of the factors that is tightly associated with freezing of gait (FOG). Temporal locomotor integration may be modulated differentially at distinct levels of the basal ganglia. Owing to its specific descending brainstem projections, stimulation of the substantia nigra pars reticulata (SNr) area might modulate spatial and temporal parameters of gait differentially compared to standard subthalamic nucleus (STN) stimulation...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29063109/-subthalamic-nucleus-from-circuits-functions-to-a-deep-brain-stimulation-target-for-the-treatment-of-parkinson-s-disease
#9
Guang-Ying Li, Qian-Xing Zhuang, Bin Li, Jian-Jun Wang, Jing-Ning Zhu
The subthalamic nucleus (STN) is the only excitatory glutamatergic nucleus in the basal ganglia circuitry. It not only is a key node in the classical indirect pathway, but also forms the "hyperdirect" pathway directly connecting the cortex, and even is implicated as a pacemaker for activity of whole basal ganglia. Due to the key position of STN in the basal ganglia circuitry, the STN is an optimal target for deep brain stimulation (DBS) in the neurosurgical treatment of Parkinson's disease (PD). However, the therapeutic mechanisms underlying the amelioration of parkinsonian motor dysfunctions induced by DBS on STN remain enigmatic...
October 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29060276/closed-loop-low-frequency-dbs-restores-thalamocortical-relay-fidelity-in-a-computational-model-of-the-motor-loop
#10
Han D Huang, Sabato Santaniello
Closed-loop modulation of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson's disease (PD) is investigated to automatically adjust the stimulation to the patients' conditions, optimize the clinical outcomes, and reduce the energy requirements. This study proposes a closed-loop control system for real-time adaptation of the STN-DBS amplitude based on the neural activity in the motor thalamus. Population-averaged post-stimulus time histograms are used to measure the average effects of STN-DBS on the thalamocortical neurons and a L2-norm minimization problem is solved to design the control algorithm, while the frequency of stimulation is kept constant...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29051496/evidence-for-a-task-dependent-switch-in-subthalamo-nigral-basal-ganglia-signaling
#11
Jay J Jantz, Masayuki Watanabe, Ron Levy, Douglas P Munoz
Basal ganglia (BG) can either facilitate or inhibit movement through excitatory and inhibitory pathways; however whether these opposing signals are dynamically regulated during healthy behavior is not known. Here, we present compelling neurophysiological evidence from three complimentary experiments in non-human primates, indicating task-specific changes in tonic BG pathway weightings during saccade behavior with different cognitive demands. First, simultaneous local field potential recording in the subthalamic nucleus (STN; BG input) and substantia nigra pars reticulata (SNr; BG output) reveals task-dependent shifts in subthalamo-nigral signals...
October 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29051091/theta-phase-closed-loop-stimulation-induces-motor-paradoxical-responses-in-the-rat-model-of-parkinson-disease
#12
Ivan Cordon, María Jesús Nicolás, Sandra Arrieta, Manuel Alegre, Julio Artieda, Miguel Valencia
BACKGROUND: High-frequency deep brain stimulation (DBS) has become a widespread therapy used in the treatment of Parkinson's Disease (PD) and other diseases. Although it has proved beneficial, much recent attention has been centered around the potential of new closed-loop DBS implementations. OBJECTIVE: Here we present a new closed-loop DBS scheme based on the phase of the theta activity recorded from the motor cortex. By testing the implementation on freely moving 6-OHDA lesioned and control rats, we assessed the behavioral and neurophysiologic effects of this implementation and compared it against the classical high-frequency DBS...
October 13, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29046357/structural-and-thermodynamic-analyses-reveal-critical-features-of-glycopeptide-recognition-by-the-human-pilr%C3%AE-immune-cell-receptor
#13
Atsushi Furukawa, Kosuke Kakita, Tomoki Yamada, Mikihiro Ishizuka, Jiro Sakamoto, Nanao Hatori, Naoyoshi Maeda, Fumina Ohsaka, Takashi Saitoh, Takao Nomura, Kimiko Kuroki, Hisanori Nambu, Hisashi Arase, Shigeki Matsunaga, Masahiro Anada, Toyoyuki Ose, Shunichi Hashimoto, Katsumi Maenaka
Before entering host cells, herpes simplex virus-1 (HSV-1) uses its envelope glycoprotein B (gB) to bind paired immunoglobulin-like type 2 receptor α (PILRα) on immune cells. PILRα belongs to the Siglec (sialic acid (SA)-binding immunoglobulin-like lectin)-like family, members of which bind SA. PILRα is the only Siglec member to recognize not only the sialylated O-linked sugar T antigen (sTn) but also its attached peptide region. We previously determined the crystal structure of PILRα complexed with the sTn-linked glycopeptide of gB, revealing the simultaneous recognition of sTn and peptide by the receptor...
October 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29044874/information-processing-from-the-motor-cortices-to-the-subthalamic-nucleus-and-globus-pallidus-and-their-somatotopic-organizations-revealed-electrophysiologically-in-monkeys
#14
Hirokazu Iwamuro, Yoshihisa Tachibana, Yoshikazu Ugawa, Nobuhito Saito, Atsushi Nambu
To understand how the information derived from different motor cortical areas representing different body parts is organized in the basal ganglia, we examined the neuronal responses in the subthalamic nucleus (STN), and the external (GPe) and internal (GPi) segments of the globus pallidus, input, relay, and output nuclei, respectively, to stimulation of the orofacial, forelimb, and hindlimb regions of the primary motor cortex (MI) and supplementary motor area (SMA) in macaque monkeys under awake state. Most STN and GPe/GPi neurons responded exclusively to stimulation of either the MI or SMA, and one-fourth to one-third of neurons responded to both...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29034586/avoiding-internal-capsule-stimulation-with-a-new-eight-channel-steering-deep-brain-stimulation-lead
#15
Kees J van Dijk, Rens Verhagen, Lo J Bour, Ciska Heida, Peter H Veltink
OBJECTIVE: Novel deep brain stimulation (DBS) lead designs are currently entering the market, which are hypothesized to provide a way to steer the stimulation field away from neural populations responsible for side effects and towards populations responsible for beneficial effects. The objective of this study is to assess the performances of a new eight channel steering-DBS lead and compare this with a conventional cylindrical contact (CC) lead. APPROACH: The two leads were evaluated in a finite element electric field model combined with multicompartment neuron and axon models, representing the internal capsule (IC) fibers and subthalamic nucleus (STN) cells...
October 15, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29033800/stimulation-of-cortico-subthalamic-projections-amplifies-resting-motor-circuit-activity-and-leads-to-increased-locomotion-in-dopamine-depleted-mice
#16
Teresa H Sanders
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in patients with Parkinson's disease (PD). STN-DBS enables similar improved motor function, including increased movement speed (reduced bradykinesia), in the 6-OHDA dopamine-depletion mouse model of PD. Previous analyses of electrophysiological recordings from STN and motor cortex (M1) have explored signaling changes that correspond to PD and amelioration of PD symptoms. The most common results show an increase in beta frequency power during 'off' states and a reduction in beta during 'on' states...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/29032347/vocalic-transitions-as-markers-of-speech-acoustic-changes-with-stn-dbs-in-parkinson-s-disease
#17
Vincent Martel-Sauvageau, Kris Tjaden
PURPOSE: Deep Brain Stimulation of the subthalamic nucleus (STN-DBS) effectively treats cardinal symptoms of idiopathic Parkinson's disease (PD) that cannot be satisfactorily managed with medication. Research is equivocal regarding speech changes associated with STN-DBS. This study investigated the impact of STN-DBS on vocalic transitions and the relationship to intelligibility. METHODS: Eight Quebec-French speakers with PD and eight healthy controls participated...
October 7, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/29017898/a-hierarchical-structure-for-human-behavior-classification-using-stn-local-field-potentials
#18
Hosein M Golshan, Adam O Hebb, Sara J Hanrahan, Joshua Nedrud, Mohammad H Mahoor
BACKGROUND: Classification of human behavior from brain signals has potential application in developing closed-loop deep brain stimulation (DBS) systems. This paper presents a human behavior classification using local field potential (LFP) signals recorded from subthalamic nuclei (STN). METHOD: A hierarchical classification structure is developed to perform the behavior classification from LFP signals through a multi-level framework (coarse to fine). At each level, the time-frequency representations of all six signals from the DBS leads are combined through an MKL-based SVM classifier to classify five tasks (speech, finger movement, mouth movement, arm movement, and random segments)...
October 7, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28991693/magnetic-resonance-and-computed-tomography-image-fusion-technology-in-patients-with-parkinson-s-disease-after-deep-brain-stimulation
#19
Jun Xia, Pin He, Xiaodong Cai, Doudou Zhang, Ni Xie
Electrode position after deep brain stimulation (DBS) for Parkinson's disease (PD) needs to be confirmed, but there are concerns about the risk of postoperative magnetic resonance imaging (MRI) after DBS. These issues could be avoided by fusion images obtained from preoperative MRI and postoperative computed tomography (CT). This study aimed to investigate image fusion technology for displaying the position of the electrodes compared with postoperative MRI. This was a retrospective study of 32 patients with PD treated with bilateral subthalamic nucleus (STN) DBS between April 2015 and March 2016...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28986718/frontal-lobe-connectivity-and-network-community-characteristics-are%C3%A2-associated-with-the-outcome-of-subthalamic-nucleus-deep-brain-stimulation-in-patients-with-parkinson-s-disease
#20
Nabin Koirala, Vinzenz Fleischer, Martin Glaser, Kirsten E Zeuner, Günther Deuschl, Jens Volkmann, Muthuraman Muthuraman, Sergiu Groppa
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is nowadays an evidence-based state of the art therapy option for motor and non-motor symptoms in patients with Parkinson's disease (PD). However, the exact anatomical regions of the cerebral network that are targeted by STN-DBS have not been precisely described and no definitive pre-intervention predictors of the clinical response exist. In this study, we test the hypothesis that the clinical effectiveness of STN-DBS depends on the connectivity profile of the targeted brain networks...
October 6, 2017: Brain Topography
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