keyword
MENU ▼
Read by QxMD icon Read
search

Stn

keyword
https://www.readbyqxmd.com/read/28924578/effects-of-subthalamic-nucleus-deep-brain-stimulation-on-objective-sleep-outcomes-in-parkinson-s-disease
#1
Amy W Amara, Harrison C Walker, Allen Joop, Gary Cutter, Jennifer L DeWolfe, Susan M Harding, David G Standaert
BACKGROUND: Sleep dysfunction is a common and disabling non-motor symptom in Parkinson's disease. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms and subjective sleep in PD, but alternative stimulation parameters to optimize sleep have not been explored. We hypothesized that low frequency STN DBS would improve objective sleep more than conventional settings. METHODS: Twenty PD subjects with STN DBS (18 unilateral, 2 bilateral) underwent 3 non-consecutive nights of polysomnography: DBS off; DBS high frequency (≥130 Hz); and DBS low frequency (60 Hz)...
March 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/28920562/comparison-of-general-and-local-anesthesia-for-deep-brain-stimulator-insertion-a-systematic-review
#2
Veena Sheshadri, Nathan C Rowland, Jigesh Mehta, Marina Englesakis, Pirjo Manninen, Lashmi Venkatraghavan
BACKGROUND: Subthalamic nucleus deep brain stimulation (STN-DBS) has become a standard treatment for many patients with Parkinson's disease (PD). The reported clinical outcome measures for procedures done under general anesthesia (GA) compared to traditional local anesthetic (LA) technique are quite heterogeneous and difficult to compare. The aim of this systematic review and metaanalysis was to determine whether the clinical outcome after STN-DBS insertion under GA is comparable to that under LA in patients with Parkinson's disease...
September 18, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28913772/weight-gain-after-subthalamic-nucleus-deep-brain-stimulation-in-parkinson-s-disease-is-influenced-by-dyskinesias-reduction-and-electrodes-position
#3
Roberta Balestrino, Damiano Baroncini, Mario Fichera, Carmine Antonio Donofrio, Alberto Franzin, Pietro Mortini, Giancarlo Comi, Maria Antonietta Volontè
Parkinson's disease is a common neurodegenerative disease that can be treated with pharmacological or surgical therapy. Subthalamic nucleus (STN) deep brain stimulation is a commonly used surgical option. A reported side effect of STN-DBS is weight gain: the aim of our study was to find those factors that determine weight gain, through one year-long observation of 32 patients that underwent surgery in our centre. During the follow-up, we considered: anthropometric features, hormonal levels, motor outcome, neuropsychological and quality of life outcomes, therapeutic parameters and electrodes position...
September 14, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28911924/sialyl-tn-identifies-muscle-invasive-bladder-cancer-basal-and-luminal-subtypes-facing-decreased-survival-being-expressed-by-circulating-tumor-cells-and-metastases
#4
Luís Lima, Manuel Neves, Marta I Oliveira, Lorena Dieguez, Rui Freitas, Rita Azevedo, Cristiana Gaiteiro, Janine Soares, Dylan Ferreira, Andreia Peixoto, Elisabete Fernandes, Diana Montezuma, Ana Tavares, Ricardo Ribeiro, Ana Castro, Manuel Oliveira, Avelino Fraga, Celso A Reis, Lúcio Lara Santos, José Alexandre Ferreira
OBJECTIVES: To evaluate the potential of sialyl-Tn (STn), a cancer-associated glycan antigen present in membrane glycoproteins, to improve a recent molecular model for stratification and prognostication of advanced stage bladder tumors based on keratins (KRT14, 5, and 20) expression. In addition, determine the association between STn and disease dissemination based on the evaluation of circulating tumor cells (CTCs) and the metastasis, which is a critical matter to improve patient management...
September 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28910619/loss-of-hyperdirect-pathway-cortico-subthalamic-inputs-following-degeneration-of-midbrain-dopamine-neurons
#5
Hong-Yuan Chu, Eileen L McIver, Ryan F Kovaleski, Jeremy F Atherton, Mark D Bevan
The motor symptoms of Parkinson's disease (PD) are linked to abnormally correlated and coherent activity in the cortex and subthalamic nucleus (STN). However, in parkinsonian mice we found that cortico-STN transmission strength had diminished by 50%-75% through loss of axo-dendritic and axo-spinous synapses, was incapable of long-term potentiation, and less effectively patterned STN activity. Optogenetic, chemogenetic, genetic, and pharmacological interrogation suggested that downregulation of cortico-STN transmission in PD mice was triggered by increased striato-pallidal transmission, leading to disinhibition of the STN and increased activation of STN NMDA receptors...
September 13, 2017: Neuron
https://www.readbyqxmd.com/read/28910611/revealing-a-role-for-nmda-receptors-in-regulating-stn-inputs-following-the-loss-of-dopamine
#6
Aphroditi A Mamaligas, Christopher P Ford
In this issue of Neuron, Chu et al. (2017) show that dopamine depletion using a 6-OHDA model causes a decrease in hyperdirect inputs from the motor cortex directly to the STN and that rescuing this loss alleviates Parkinsonian symptoms.
September 13, 2017: Neuron
https://www.readbyqxmd.com/read/28903359/expression-of-sialyl-tn-sugar-antigen-in-bladder-cancer-cells-affects-response-to-bacillus-calmette-gu%C3%A3-rin-bcg-and-to-oxidative-damage
#7
Paulo F Severino, Mariana Silva, Mylene Carrascal, Nadia Malagolini, Mariella Chiricolo, Giulia Venturi, Annalisa Astolfi, Mariangela Catera, Paula A Videira, Fabio Dall'Olio
The sialyl-Tn (sTn) antigen is an O-linked carbohydrate chain aberrantly expressed in bladder cancer (BC), whose biosynthesis is mainly controlled by the sialyltransferase ST6GALNAC1. Treatment with Bacillus Calmette-Guérin (BCG) is the most effective adjuvant immunotherapy for superficial BC but one third of the patients fail to respond. A poorly understood correlation between the expression of sTn and BC patient's response to BCG was previously observed. By analyzing tumor tissues, we showed that patients with high ST6GALNAC1 and IL-6 mRNA expression were BCG responders...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28894620/programming-for-stimulation-induced-transient-nonmotor-psychiatric-symptoms-after-bilateral-subthalamic-nucleus-deep-brain-stimulation-for-parkinson-s-disease
#8
Xi Wu, Yiqing Qiu, Keith Simfukwe, Jiali Wang, Jianchun Chen, Xiaowu Hu
BACKGROUND: Stimulation-induced transient nonmotor psychiatric symptoms (STPSs) are side effects following bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients. We designed algorithms which (1) determine the electrode contacts that induce STPSs and (2) provide a programming protocol to eliminate STPS and maintain the optimal motor functions. Our objective is to test the effectiveness of these algorithms. MATERIALS AND METHODS: 454 PD patients who underwent programming sessions after STN-DBS implantations were retrospectively analyzed...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28890315/subthalamic-neural-entropy-is-a-feature-of-freezing-of-gait-in-freely-moving-people-with-parkinson-s-disease
#9
Judy Syrkin-Nikolau, Mandy Miller Koop, Thomas Prieto, Chioma Anidi, Muhammad Furqan Afzal, Anca Velisar, Zack Blumenfeld, Talora Martin, Megan Trager, Helen Bronte-Stewart
The goal of this study was to investigate subthalamic (STN) neural features of Freezers and Non-Freezers with Parkinson's disease (PD), while freely walking without freezing of gait (FOG) and during periods of FOG, which were better elicited during a novel turning and barrier gait task than during forward walking. METHODS: Synchronous STN local field potentials (LFPs), shank angular velocities, and ground reaction forces were measured in fourteen PD subjects (eight Freezers) off medication, OFF deep brain stimulation (DBS), using an investigative, implanted, sensing neurostimulator (Activa® PC+S, Medtronic, Inc...
September 7, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28889124/factors-affecting-stereotactic-accuracy-in-image-guided-deep-brain-stimulator-electrode-placement
#10
Andrew L Ko, Aly Ibrahim, Philippe Magown, Rebecca Macallum, Kim J Burchiel
BACKGROUND/AIMS: Intraoperative imaging allows near-real-time assessment of stereotactic accuracy during implantation of deep brain stimulation (DBS) electrodes. Such technology can be used to examine factors impacting stereotactic error. METHODS: Intraoperative CT imaging was reviewed in patients undergoing DBS placement at Oregon Health and Sciences University. Coordinates of the target electrode were compared to the operative plan to characterize the magnitude and direction of stereotactic error with respect to side of implantation, target, and electrode approach angles...
September 9, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28887071/pathological-crying-induced-by-deep-brain-stimulation-of-the-subthalamic-nucleus-in-parkinson-s-disease
#11
Marc E Wolf, Mahmoud Abdallat, Christian Blahak, Joachim K Krauss
We report on a patient with deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) who developed pathologic crying (PC) immediately postoperatively. A spread of DBS current to adjacent cortico-ponto-cerebellar pathways might be responsible. In contrast to the few cases published previously, there was no pre-existing additional lesion that would have favoured occurrence of PC. Treating physicians should be aware of DBS-induced PC.
September 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28882161/general-anesthesia-versus-local-anesthesia-in-stereotaxy-galaxy-for-parkinson-s-disease-study-protocol-for-a-randomized-controlled-trial
#12
R A Holewijn, D Verbaan, R M A de Bie, P R Schuurman
BACKGROUND: The aim of the study is to investigate if deep brain stimulation (DBS) in the subthalamic nucleus (STN) for Parkinson's disease (PD) under general anesthesia further improves outcome by lessening postoperative cognitive, mood, and behavioral adverse effects; shorten surgical time and hospital admittance; and produce comparable symptomatic and functional improvement to surgery under local anesthesia. METHODS/DESIGN: The study will be a single-center, prospective, randomized, open-label, blinded endpoint trial comparing DBS under general anesthesia with DBS under local anesthesia...
September 7, 2017: Trials
https://www.readbyqxmd.com/read/28871419/thalamic-and-basal-ganglia-regions-are-involved-in-attentional-processing-of-behaviorally-significant-events-evidence-from-simultaneous-depth-and-scalp-eeg
#13
Anne-Kathrin Beck, Götz Lütjens, Kerstin Schwabe, Reinhard Dengler, Joachim K Krauss, Pascale Sandmann
Extensive descriptions exist on cortical responses to change in the acoustic environment. However, the involvement of subcortical regions is not well understood. Here we present simultaneous recordings of cortical and subcortical event-related potentials (ERPs) to different pure tones in patients undergoing surgery for deep brain stimulation (DBS). These patients had externalized electrodes in the subthalamic nucleus (STN), the ventrolateral posterior thalamus (VLp) or the globus pallidus internus (GPi). Subcortical and cortical ERPs were analyzed upon presentation of one frequent non-target stimulus and two infrequent stimuli, either being a target or a distractor stimulus...
September 4, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28867989/exhaled-breath-analysis-a-review-of-breath-taking-methods-for-off-line-analysis
#14
REVIEW
Oluwasola Lawal, Waqar M Ahmed, Tamara M E Nijsen, Royston Goodacre, Stephen J Fowler
BACKGROUND: The potential of exhaled breath sampling and analysis has long attracted interest in the areas of medical diagnosis and disease monitoring. This interest is attributed to its non-invasive nature, access to an unlimited sample supply (i.e., breath), and the potential to facilitate a rapid at patient diagnosis. However, progress from laboratory setting to routine clinical practice has been slow. Different methodologies of breath sampling, and the consequent difficulty in comparing and combining data, are considered to be a major contributor to this...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28866626/sleep-patterns-in-parkinson-s-disease-direct-recordings-from-the-subthalamic-nucleus
#15
John A Thompson, Anand Tekriwal, Gidon Felsen, Musa Ozturk, Ilknur Telkes, Jiangping Wu, Nuri Firat Ince, Aviva Abosch
Sleep is a fundamental homeostatic process, and disorders of sleep can greatly affect quality of life. Parkinson's disease (PD) is highly comorbid for a spectrum of sleep disorders and deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been reported to improve sleep architecture in PD. We studied local field potential (LFP) recordings in PD subjects undergoing STN-DBS over the course of a full-night's sleep. We examined the changes in oscillatory activity recorded from STN between ultradian sleep states to determine whether sleep-stage dependent spectral patterns might reflect underlying dysfunction...
September 2, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28853174/blockade-of-5-ht3-receptors-with-granisetron-does-not-affect-trigeminothalamic-nociceptive-transmission-in-rats-implication-for-migraine
#16
Alexey Y Sokolov, Ivan B Sivachenko, Sergey S Panteleev, Olga A Lyubashina
A perspective way to expand the existing range of anti-migraine drugs seems to be the search for pharmacological agents with anti-cephalalgic properties among medicines approved for clinical indications other than migraine. Numerous experimental and clinical data imply that selective serotonin 5-HT3 receptor antagonists can be considered as potential anti-migraine agents. Therefore, the objective of our work was to examine the impact of selective 5-HT3 receptor blockade with granisetron on migraine-related nociceptive transmission within the spinal trigeminal nucleus (STN) and the ventroposteromedial nucleus of the thalamus (VPM)...
August 29, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28842656/deep-brain-stimulation-of-the-subthalamic-nucleus-does-not-negatively-affect-social-cognitive-abilities-of-patients-with-parkinson-s-disease
#17
Ivan Enrici, Antonia Mitkova, Lorys Castelli, Michele Lanotte, Leonardo Lopiano, Mauro Adenzato
Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with advanced idiopathic PD successful at alleviating disabling motor symptoms. Nevertheless, the effects of STN-DBS on cognitive functions remain controversial and few studies have investigated modification of social cognitive abilities in patients with PD treated with STN-DBS. Here we expanded the typically-investigated spectrum of these abilities by simultaneously examining emotion recognition, and both affective and cognitive Theory of Mind (ToM)...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842228/microelectrode-recording-guided-versus-intraoperative-mri-guided-in-stn-deep-brain-stimulation-surgery-for-parkinson-s-disease-a-one-year-follow-up-study
#18
Xuemeng Liu, Jibo Zhang, Kai Fu, Rui Gong, Jincao Chen, Jie Zhang
Microelectrode recording (MER) and Intraoperative MRI (iMRI) have been used in DBS surgery for Parkinson's disease (PD), but comparative methodology is as yet lacking. Therefore, we compared the one-year follow-up outcomes of MER guided and iMRI guided STN-DBS surgery in PD patients. METHOD: We conducted a review comparing PD patients who underwent MER guided (n=76, group A) and iMRI guided STN-DBS surgery (n=61, group B ) in our institution. Pre- and postoperative assessments included UPDRS-III score, PDQ-39, MMSE, LEDDs and MR images...
August 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28836295/microglia-may-compensate-for-dopaminergic-neuron-loss-in-experimental-parkinsonism-through-selective-elimination-of-glutamatergic-synapses-from-the-subthalamic-nucleus
#19
Hitomi Aono, Mohammed Emamussalehin Choudhury, Hiromi Higaki, Kazuya Miyanishi, Yuka Kigami, Kohdai Fujita, Jun-Ichi Akiyama, Hisaaki Takahashi, Hajime Yano, Madoka Kubo, Noriko Nishikawa, Masahiro Nomoto, Junya Tanaka
Parkinson's disease (PD) symptoms do not become apparent until most dopaminergic neurons in the substantia nigra pars compacta (SNc) degenerate, suggesting that compensatory mechanisms play a role. Here, we investigated the compensatory involvement of activated microglia in the SN pars reticulata (SNr) and the globus pallidus (GP) in a 6-hydroxydopamine-induced rat hemiparkinsonism model. Activated microglia accumulated more markedly in the SNr than in the SNc in the model. The cells had enlarged somata and expressed phagocytic markers CD68 and NG2 proteoglycan in a limited region of the SNr, where synapsin I- and postsynaptic density 95-immunoreactivities were reduced...
August 24, 2017: Glia
https://www.readbyqxmd.com/read/28835526/parkinsonism-and-vigilance-alteration-in-neural-oscillatory-activity-and-phase-amplitude-coupling-in-the-basal-ganglia-and-motor-cortex
#20
David Escobar, Luke A Johnson, Shane D Nebeck, Jianyu Zhang, Matthew D Johnson, Kenneth B Baker, Gregory F Molnar, Jerrold L Vitek
Oscillatory neural activity in different frequency bands as well as phase-amplitude coupling (PAC) are hypothesized to be biomarkers of Parkinson's disease (PD) that could explain dysfunction in the motor circuit and be used for closed-loop deep brain stimulation (DBS). How these putative biomarkers change from the normal to the parkinsonian state, across nodes in the motor circuit, and within the same subject, however, remains unknown. In this study, we characterized how parkinsonism and vigilance altered oscillatory activity and PAC within the primary motor cortex (M1), subthalamic nucleus (STN), and globus pallidus (GP) in two nonhuman primates...
August 23, 2017: Journal of Neurophysiology
keyword
keyword
83834
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"