keyword
MENU ▼
Read by QxMD icon Read
search

Stn

keyword
https://www.readbyqxmd.com/read/28103527/distinct-cortico-striatal-connections-with-subthalamic-nucleus-underlie-facets-of-compulsivity
#1
Laurel S Morris, Kwangyeol Baek, Valerie Voon
The capacity to flexibly respond to contextual changes is crucial to adapting to a dynamic environment. Compulsivity, or behavioural inflexibility, consists of heterogeneous subtypes with overlapping yet discrete neural substrates. The subthalamic nucleus (STN) mediates the switch from automatic to controlled processing to slow, break or stop behaviour when necessary. Rodent STN lesions or inactivation are linked with perseveration or repetitive, compulsive responding. However, there are few studies examining the role of latent STN-centric neural networks and compulsive behaviour in healthy individuals...
December 29, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28094018/single-cell-analysis-reveals-a-close-relationship-between-differentiating-dopamine-and-subthalamic-nucleus-neuronal-lineages
#2
Nigel Kee, Nikolaos Volakakis, Agnete Kirkeby, Lina Dahl, Helena Storvall, Sara Nolbrant, Laura Lahti, Åsa K Björklund, Linda Gillberg, Eliza Joodmardi, Rickard Sandberg, Malin Parmar, Thomas Perlmann
Stem cell engineering and grafting of mesencephalic dopamine (mesDA) neurons is a promising strategy for brain repair in Parkinson's disease (PD). Refinement of differentiation protocols to optimize this approach will require deeper understanding of mesDA neuron development. Here, we studied this process using transcriptome-wide single-cell RNA sequencing of mouse neural progenitors expressing the mesDA neuron determinant Lmx1a. This approach resolved the differentiation of mesDA and neighboring neuronal lineages and revealed a remarkably close relationship between developing mesDA and subthalamic nucleus (STN) neurons, while also highlighting a distinct transcription factor set that can distinguish between them...
January 5, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28089264/development-and-validation-of-the-deep-brain-stimulation-impairment-scale-dbs-is
#3
Franziska Maier, Catharine J Lewis, Carsten Eggers, Andrea A Kühn, Henriette Krug, Jens Volkmann, Anna D Kirsch, Lars Wojtecki, Alfons Schnitzler, Günther Deuschl, Joachim K Krauss, Christiane Woopen, Lars Timmermann
BACKGROUND: Bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) has considerable influence on motor and non-motor symptoms in Parkinson's disease (PD). While improvements in motor functioning can be easily assessed with general quality of life questionnaires, the measurement of specific STN-DBS-associated impairments often remains insufficient. Hence, we aimed to develop a questionnaire that measures STN-DBS-related impairments. METHODS: The development of the (STN-)DBS Impairment Scale (DBS-IS) consisted of four steps...
January 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28088795/influence-of-intracranial-air-on-electrode-position-and-clinical-outcomes-following-deep-brain-stimulation-for-parkinson-s-disease
#4
J Nicole Bentley, Zhe Guan, Karen S Cummings, Kelvin L Chou, Parag G Patil
BACKGROUND: The introduction of intracranial air during deep brain stimulation (DBS) surgery is believed to negatively impact targeting accuracy and clinical outcomes. OBJECTIVE: To quantify the relationship between intracranial air (ICA) volumes, targeting accuracy, and clinical outcomes in patients undergoing subthalamic nucleus (STN) DBS for Parkinson's disease. METHODS: ICA in 73 consecutive STN DBS cases (146 leads) was measured by high-resolution CT and correlated with proximal lead bowing, electrode displacement, targeting accuracy, and clinical outcomes at 6 and 12 months...
January 14, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28088666/vocal-emotion-decoding-in-the-subthalamic-nucleus-an-intracranial-erp-study-in-parkinson-s-disease
#5
Julie Péron, Olivier Renaud, Claire Haegelen, Lucas Tamarit, Valérie Milesi, Jean-François Houvenaghel, Thibaut Dondaine, Marc Vérin, Paul Sauleau, Didier Grandjean
Using intracranial local field potential (LFP) recordings in patients with Parkinson's disease (PD) undergoing deep brain stimulation (DBS), we explored the electrophysiological activity of the subthalamic nucleus (STN) in response to emotional stimuli in the auditory modality. Previous studies focused on the influence of visual stimuli. To this end, we recorded LFPs within the STN in response to angry, happy, and neutral prosodies in 13 patients with PD who had just undergone implantation of DBS electrodes...
January 12, 2017: Brain and Language
https://www.readbyqxmd.com/read/28081139/long-latency-somatosensory-evoked-potentials-of-the-subthalamic-nucleus-in-patients-with-parkinson-s-disease
#6
Carlos Trenado, Saskia Elben, Lena Friggemann, Sonja Gruhn, Stefan Jun Groiss, Jan Vesper, Alfons Schnitzler, Lars Wojtecki
Somatosensory evoked potentials (SSEPs) are a viable way to measure processing of somatosensory information. SSEPs have been described at the scalp and the cortical level by electroencephalographic, magnetoencephalographic and intracranial cortical recordings focusing on short-latency (SL; latency<40 ms) and long-latency (LL; latency>40 ms) SSEPs as well as by deep brain stimulation (DBS) electrode studies targeting SL-SSEPs. Unfortunately, LL-SSEPs have not been addressed at the subcortical level aside from the fact that studies targeting the characteristics and generators of SSEPs have been neglected for the last ten years...
2017: PloS One
https://www.readbyqxmd.com/read/28076964/trigeminal-neuralgia-diagnosis-and-treatment
#7
Stine Maarbjerg, Giulia Di Stefano, Lars Bendtsen, Giorgio Cruccu
Introduction Trigeminal neuralgia (TN) is characterized by touch-evoked unilateral brief shock-like paroxysmal pain in one or more divisions of the trigeminal nerve. In addition to the paroxysmal pain, some patients also have continuous pain. TN is divided into classical TN (CTN) and secondary TN (STN). Etiology and pathophysiology Demyelination of primary sensory trigeminal afferents in the root entry zone is the predominant pathophysiological mechanism. Most likely, demyelination paves the way for generation of ectopic impulses and ephaptic crosstalk...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28076357/soil-leaf-and-root-ecological-stoichiometry-of-caragana-korshinskii-on-the-loess-plateau-of-china-in-relation-to-plantation-age
#8
Quanchao Zeng, Rattan Lal, Yanan Chen, Shaoshan An
Caragana korshinskii, a leguminous shrub, a common specie, is widely planted to prevent soil erosion on the Loess Plateau. The objective of this study was to determine how the plantation ages affected soil, leaf and root nutrients and ecological stoichiometry. The chronosequence ages of C. korshinskii plantations selected for this study were 10, 20 and 30 years. Soil organic carbon (SOC) and soil total nitrogen (STN) of C. korshinskii plantations significantly increased with increase in the chronosequence age...
2017: PloS One
https://www.readbyqxmd.com/read/28065487/the-effect-of-unilateral-subthalamic-nucleus-deep-brain-stimulation-on-depression-in-parkinson-s-disease
#9
Elizabeth L Birchall, Harrison C Walker, Gary Cutter, Stephanie Guthrie, Allen Joop, Raima A Memon, Ray L Watts, David G Standaert, Amy W Amara
BACKGROUND: Depression is common in Parkinson's disease (PD) and adversely affects quality of life. Both unilateral and bilateral subthalamic (STN) deep brain stimulation (DBS) effectively treat the motor symptoms of PD, but questions remain regarding the impact of unilateral STN DBS on non-motor symptoms, such as depression. METHODS: We report changes in depression, as measured by the Hamilton Depression Rating Scale (HAMD-17), in 50 consecutive PD patients who underwent unilateral STN DBS...
December 27, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/28055131/subthalamic-nuclei-stimulation-in-patients-with-pantothenate-kinase-associated-neurodegeneration-pkan
#10
Ziyuan Liu, Yang Liu, Yingmai Yang, Lin Wang, Wanchen Dou, Jinzhu Guo, Yu Wang, Yi Guo, Xinhua Wan, Wenbin Ma, Renzhi Wang
INTRODUCTION: Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive genetic disease that leads to extrapyramidal symptoms, such as dystonia, ataxia, dysarthria, and involuntary movements. Treatment of PKAN with deep brain stimulation (DBS) has been reported, but mainly focuses on targeting the globus pallidus internus (GPi). Subthalamic nuclei (STN) may also be a potential target for treatment of PKAN. METHODS: In this study, we reviewed three patients with PKAN (two with typical PKAN and one with atypical PKAN) treated by bilateral STN stimulation and present a review of the literature...
January 5, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28042095/reduced-noradrenergic-innervation-of-ventral-midbrain-dopaminergic-cell-groups-and-the-subthalamic-nucleus-in-mptp-treated-parkinsonian-monkeys
#11
Gunasingh Jeyaraj Masilamoni, Olivia Groover, Yoland Smith
There is anatomical and functional evidence that ventral midbrain dopaminergic (DA) cell groups and the subthalamic nucleus (STN) receive noradrenergic innervation in rodents, but much less is known about these interactions in primates. Degeneration of NE neurons in the locus coeruleus (LC) and related brainstem NE cell groups is a well-established pathological feature of Parkinson's disease (PD), but the development of such pathology in animal models of PD has been inconsistent across species and laboratories...
December 30, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/28039987/a-neural-mass-model-of-basal-ganglia-nuclei-simulates-pathological-beta-rhythm-in-parkinson-s-disease
#12
Fei Liu, Jiang Wang, Chen Liu, Huiyan Li, Bin Deng, Chris Fietkiewicz, Kenneth A Loparo
An increase in beta oscillations within the basal ganglia nuclei has been shown to be associated with movement disorder, such as Parkinson's disease. The motor cortex and an excitatory-inhibitory neuronal network composed of the subthalamic nucleus (STN) and the external globus pallidus (GPe) are thought to play an important role in the generation of these oscillations. In this paper, we propose a neuron mass model of the basal ganglia on the population level that reproduces the Parkinsonian oscillations in a reciprocal excitatory-inhibitory network...
December 2016: Chaos
https://www.readbyqxmd.com/read/28033133/stn-finance-update
#13
Maria McMahon
No abstract text is available yet for this article.
January 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/28013397/cortico-subthalamic-inputs-from-the-motor-limbic-and-associative-areas-in-normal-and-dopamine-depleted-rats-are-not-fully-segregated
#14
Marcus L F Janssen, Yasin Temel, Claire Delaville, Daphne G M Zwartjes, Tjitske Heida, Philippe De Deurwaerdère, Veerle Visser-Vandewalle, Abdelhamid Benazzouz
The subthalamic nucleus (STN) receives monosynaptic glutamatergic afferents from different areas of the cortex, known as the "hyperdirect" pathway. The STN has been divided into three distinct subdivisions, motor, limbic, and associative parts in line with the concept of parallel information processing. The extent to which the parallel information processing coming from distinct cortical areas overlaps in the different territories of the STN is still a matter of debate and the proposed role of dopaminergic neurons in maintaining the coherence of responses to cortical inputs in each territory is not documented...
December 24, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/28009826/using-functional-target-coordinates-of-the-subthalamic-nucleus-to-assess-the-indirect-and-direct-methods-of-the-preoperative-planning-do-the-anatomical-and-functional-targets-coincide
#15
Ahmed Rabie, Leo Verhagen Metman, Konstantin V Slavin
OBJECTIVE: To answer the question of whether the anatomical center of the subthalamic nucleus (STN), as calculated indirectly from stereotactic atlases or by direct visualization on magnetic resonance imaging (MRI), corresponds to the best functional target. Since the neighboring red nucleus (RN) is well visualized on MRI, we studied the relationships of the final target to its different borders. METHODS: We analyzed the data of 23 PD patients (46 targets) who underwent bilateral frame-based STN deep brain stimulation (DBS) procedure with microelectrode recording guidance...
December 21, 2016: Brain Sciences
https://www.readbyqxmd.com/read/28006786/neuropsychological-outcome-in-subthalamic-nucleus-stimulation-surgeries-with-electrodes-passing-through-the-caudate-nucleus
#16
Cihan Isler, Angela Albi, Frédéric L W V J Schaper, Yasin Temel, Annelien Duits
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson disease (PD) is associated with postoperative cognitive decline. One of the proposed underlying mechanisms is the surgical procedure with the lead trajectory penetrating the caudate nucleus. OBJECTIVE: To study whether penetration of the caudate nucleus affects neuropsychological outcome. METHODS: Neuropsychological and imaging data of 30 PD patients who underwent bilateral STN DBS were analysed...
December 23, 2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27999534/striatal-dopaminergic-innervation-regulates-subthalamic-beta-oscillations-and-cortical-subcortical-coupling-during-movements-preliminary-evidence-in-subjects-with-parkinson-s-disease
#17
Andrea Canessa, Nicolò G Pozzi, Gabriele Arnulfo, Joachim Brumberg, Martin M Reich, Gianni Pezzoli, Maria F Ghilardi, Cordula Matthies, Frank Steigerwald, Jens Volkmann, Ioannis U Isaias
Activation of the basal ganglia has been shown during the preparation and execution of movement. However, the functional interaction of cortical and subcortical brain areas during movement and the relative contribution of dopaminergic striatal innervation remains unclear. We recorded local field potential (LFP) activity from the subthalamic nucleus (STN) and high-density electroencephalography (EEG) signals in four patients with Parkinson's disease (PD) off dopaminergic medication during a multi-joint motor task performed with their dominant and non-dominant hand...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27995895/early-dysfunction-and-progressive-degeneration-of-the-subthalamic-nucleus-in-mouse-models-of-huntington-s-disease
#18
Jeremy F Atherton, Eileen L McIver, Matthew Rm Mullen, David L Wokosin, D James Surmeier, Mark D Bevan
The subthalamic nucleus (STN) is an element of cortico-basal ganglia-thalamo-cortical circuitry critical for action suppression. In Huntington's disease (HD) action suppression is impaired, resembling the effects of STN lesioning or inactivation. To explore this potential linkage, the STN was studied in BAC transgenic and Q175 knock-in mouse models of HD. At <2 and 6 months of age autonomous STN activity was impaired due to activation of KATP channels. STN neurons exhibited prolonged NMDA receptor-mediated synaptic currents, caused by a deficit in glutamate uptake, and elevated mitochondrial oxidant stress, which was ameliorated by NMDA receptor antagonism...
December 20, 2016: ELife
https://www.readbyqxmd.com/read/27994936/the-impact-of-deep-brain-stimulation-on-tinnitus
#19
Jasper V Smit, Marcus L F Janssen, Malou Engelhard, Rob M A de Bie, P Richard Schuurman, Maria F Contarino, Arne Mosch, Yasin Temel, Robert J Stokroos
BACKGROUND: Tinnitus is a disorder of the nervous system that cannot be adequately treated with current therapies. The effect of neuromodulation induced by deep brain stimulation (DBS) on tinnitus has not been studied well. This study investigated the effect of DBS on tinnitus by use of a multicenter questionnaire study. METHODS: Tinnitus was retrospectively assessed prior to DBS and at the current situation (with DBS). From the 685 questionnaires, 443 were returned...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27994690/unusual-uptake-of-prostate-specific-tracer-68-ga-psma-hbed-cc-in-a-benign-thyroid-nodule
#20
Nishikant Avinash Damle, Madhavi Tripathi, Partha Sarathi Chakraborty, Manas Kumar Sahoo, Chandrasekhar Bal, Shipra Aggarwal, Geetanjali Arora, Praveen Kumar, Rajeev Kumar, Ravikant Gupta
(68)Ga-Prostate specific membrane antigen- N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT, is able to detect a small volume of recurrent prostate carcinoma (PC) when there is a prostate specific antigen (PSA) rise on follow-up after prostatectomy or other definitive treatment for PC. The use of PSMA PET/CT in the initial staging in PC is uncertain at this time. Clinical studies are underway to define its exact role in the management of the disease...
December 2016: Nuclear Medicine and Molecular Imaging
keyword
keyword
83834
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"