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Keywords
допплер, сахарны...
допплер, сахарный диабет, нарушение толерантности к глюкоза, ультразвуковое исследование сосудов почки, орбитальный кровоток, диабетичес
#21
RANDOMIZED CONTROLLED TRIAL
Teresa Vanessa Fiorentino, Adriana Monroy, Subash Kamath, Rosa Sotero, Michele Dei Cas, Giuseppe Daniele, Alberto O Chavez, Muhammad Abdul-Ghani, Marta Letizia Hribal, Giorgio Sesti, Devjit Tripathy, Ralph A DeFronzo, Franco Folli
CONTEXT: In this study, we aimed to identify the determinants of mitochondrial dysfunction in skeletal muscle (SKLM) of subjects with type 2 diabetes (T2DM), and to evaluate the effect of pioglitazone (PIO) on SKLM mitochondrial proteome. METHODS: Two different groups of adults were studied. Group I consisted of 8 individuals with normal glucose tolerance (NGT) and 8 with T2DM, subjected to SKLM mitochondrial proteome analysis by 2D-gel electrophoresis followed by mass spectrometry-based protein identification...
January 2021: Metabolism: Clinical and Experimental
#22
JOURNAL ARTICLE
A S Pinheiro-Torres, A P Ferreira-Duarte, W M Takeshita, V O Gushiken, I A Roncalho-Buck, G F Anhê, E Antunes, I A DeSouza
BACKGROUND: Differentiation of bone marrow eosinophils (BM-EO) and its trafficking to peripheral blood and respiratory mucosa are a hallmark of inflammatory diseases. Staphylococcal enterotoxin B (SEB) has been shown to aggravate airways eosinophilic inflammation. This study aimed to investigate the effects of mouse airways SEB exposure on BM-EO population, as well as its adhesive properties and release of cytokines/chemokines that orchestrate BM-EO trafficking to lungs. METHODS: Male BALB/c mice were intranasally exposed to SEB (1 μg), and at 4, 16, 24 and 48 h thereafter, bone marrow (BM), circulating blood and bronchoalveolar lavage (BAL) fluid were collected...
October 30, 2020: Life Sciences
#23
JOURNAL ARTICLE
Mathias Gorski, Bettina Jung, Yong Li, Pamela R Matias-Garcia, Matthias Wuttke, Stefan Coassin, Chris H L Thio, Marcus E Kleber, Thomas W Winkler, Veronika Wanner, Jin-Fang Chai, Audrey Y Chu, Massimiliano Cocca, Mary F Feitosa, Sahar Ghasemi, Anselm Hoppmann, Katrin Horn, Man Li, Teresa Nutile, Markus Scholz, Karsten B Sieber, Alexander Teumer, Adrienne Tin, Judy Wang, Bamidele O Tayo, Tarunveer S Ahluwalia, Peter Almgren, Stephan J L Bakker, Bernhard Banas, Nisha Bansal, Mary L Biggs, Eric Boerwinkle, Erwin P Bottinger, Hermann Brenner, Robert J Carroll, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Josef Coresh, Martin H de Borst, Frauke Degenhardt, Kai-Uwe Eckardt, Karlhans Endlich, Andre Franke, Sandra Freitag-Wolf, Piyush Gampawar, Ron T Gansevoort, Mohsen Ghanbari, Christian Gieger, Pavel Hamet, Kevin Ho, Edith Hofer, Bernd Holleczek, Valencia Hui Xian Foo, Nina Hutri-Kähönen, Shih-Jen Hwang, M Arfan Ikram, Navya Shilpa Josyula, Mika Kähönen, Chiea-Chuen Khor, Wolfgang Koenig, Holly Kramer, Bernhard K Krämer, Brigitte Kühnel, Leslie A Lange, Terho Lehtimäki, Wolfgang Lieb, Ruth J F Loos, Mary Ann Lukas, Leo-Pekka Lyytikäinen, Christa Meisinger, Thomas Meitinger, Olle Melander, Yuri Milaneschi, Pashupati P Mishra, Nina Mononen, Josyf C Mychaleckyj, Girish N Nadkarni, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M Nolte, Michelle L O'Donoghue, Marju Orho-Melander, Sarah A Pendergrass, Brenda W J H Penninx, Michael H Preuss, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Rainer Rettig, Myriam Rheinberger, Kenneth M Rice, Alexander R Rosenkranz, Peter Rossing, Jerome I Rotter, Charumathi Sabanayagam, Helena Schmidt, Reinhold Schmidt, Ben Schöttker, Christina-Alexandra Schulz, Sanaz Sedaghat, Christian M Shaffer, Konstantin Strauch, Silke Szymczak, Kent D Taylor, Johanne Tremblay, Layal Chaker, Pim van der Harst, Peter J van der Most, Niek Verweij, Uwe Völker, Melanie Waldenberger, Lars Wallentin, Dawn M Waterworth, Harvey D White, James G Wilson, Tien-Yin Wong, Mark Woodward, Qiong Yang, Masayuki Yasuda, Laura M Yerges-Armstrong, Yan Zhang, Harold Snieder, Christoph Wanner, Carsten A Böger, Anna Köttgen, Florian Kronenberg, Cristian Pattaro, Iris M Heid
Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2 /year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1...
April 2021: Kidney International
#24
JOURNAL ARTICLE
Lorilei M Alley, Alexandra C Schmid, Katja Doerschner
Many objects that we encounter have typical material qualities: spoons are hard, pillows are soft, and Jell-O dessert is wobbly. Over a lifetime of experiences, strong associations between an object and its typical material properties may be formed, and these associations not only include how glossy, rough, or pink an object is, but also how it behaves under force: we expect knocked over vases to shatter, popped bike tires to deflate, and gooey grilled cheese to hang between two slices of bread when pulled apart...
November 2, 2020: Journal of Vision
#25
JOURNAL ARTICLE
Yannick Petit, Alexandra Peña, Patricia Segonds, Jérôme Debray, Simon Joly, Andrius Zukauskas, Fredrik Laurell, Valdas Pasiskevicius, Carlota Canalias, Benoît Boulanger
We worked on a new scheme of quasi-phase matching (QPM) based on the negative first order of the spatial modulation of the sign of the second-order nonlinearity. Applying this scheme in the case of angular-QPM (AQPM) in a biaxial crystal reveals new directions of propagation for efficient parametric frequency conversion as well as "giant" spectral acceptances. The experimental validation is performed in a periodically poled rubidium-doped K T i O P O 4 biaxial crystal. This new approach naturally extends to other periodically poled uniaxial crystals such as periodically poled L i N b O 3 ...
November 1, 2020: Optics Letters
#26
JOURNAL ARTICLE
Ultraviolet C lasing at 263 nm from Ba 2 LaF 7 :Yb 3+ ,Tm 3+ upconversion nanocrystal microcavities.
Ting Wang, Bitao Liu, Yue Lin, Qihua Yang, Wei Gao, Ming Jie Li, Jianbei Qiu, Xue Yu, Xuhui Xu, Siu Fung Yu
It is a daunting challenge to realize ultraviolet C (UVC) lasing (i.e., has a wavelength range from 200 to 275 nm) from upconversion nanocrystals due to their low upconversion efficiency. Here, we fabricate B a 2 L a F 7 : Y b 3+ (90 m o l % ), T m 3+ (5 m o l % ) upconversion nanocrystals from amorphous borosilicate glass to support emission at ∼263 n m under 980 nm ns laser excitation. The excitation threshold can be further reduced from ∼130 to ∼26.5 m J / c m 2 by using a cylindrical microcavity. We also found that the growth of defect-free B a 2 L a F 7 nanocrystals with a high concentration of codoping Y b 3+ and T m 3+ ions inside high optical damage threshold borosilicate glass is the key to achieving room-temperature UVC upconversion lasing under high-intensity excitation...
November 1, 2020: Optics Letters
#27
JOURNAL ARTICLE
Shuman He, Lei Xu, Jeffrey Skidmore, Xiuhua Chao, William J Riggs, Ruijie Wang, Chloe Vaughan, Jianfen Luo, Michelle Shannon, Cynthia Warner
OBJECTIVES: The aim of this study is to (1) investigate the effects of increasing the pulse phase duration (PPD) on the neural response of the electrically stimulated cochlear nerve (CN) in children with CN deficiency (CND) and (2) compare the results from the CND population to those measured in children with normal-sized CNs. DESIGN: Study participants included 30 children with CND and 30 children with normal-sized CNs. All participants used a Cochlear Nucleus device in the test ear...
November 2020: Ear and Hearing
#28
JOURNAL ARTICLE
Rahul Sangani, Edward Rojas, Michael Forte, Rafia Zulfikar, Nicole Prince, Antonios Tasoglou, Travis Goldsmith, Gary Casuccio, Jonathan Boyd, I Mark Olfert, Melina Flanagan, Sunil Sharma
Background: Electronic cigarette use has increased dramatically since their introduction in 2007. Respiratory complications, particularly lipoid pneumonia, have been reported as early as 2012. An outbreak of pulmonary injury in 2019 has been reported in patients using vaping products. Research Question: To describe a rural Appalachian tertiary center's experience of EVALI and to identify novel mechanisms of pulmonary injury patterns. Study Design and Methods: We present a consecutive case series of 17 patients admitted to our rural, academic, tertiary care institution with EVALI from August 2019 to March 2020...
April 2021: Hospital Practice (Minneapolis)
#29
JOURNAL ARTICLE
Hyeongtaek Lim, Michael L Baker, Ryan E Cowley, Sunghee Kim, Mayukh Bhadra, Maxime A Siegler, Thomas Kroll, Dimosthenis Sokaras, Tsu-Chien Weng, Dalia R Biswas, David M Dooley, Kenneth D Karlin, Britt Hedman, Keith O Hodgson, Edward I Solomon
Cu(I) active sites in metalloproteins are involved in O2 activation, but their O2 reactivity is difficult to study due to the Cu(I) d10 closed shell which precludes the use of conventional spectroscopic methods. Kβ X-ray emission spectroscopy (XES) is a promising technique for investigating Cu(I) sites as it detects photons emitted by electronic transitions from occupied orbitals. Here, we demonstrate the utility of Kβ XES in probing Cu(I) sites in model complexes and a metalloprotein. Using Cu(I)Cl, emission features from double-ionization (DI) states are identified using varying incident X-ray photon energies, and a reasonable method to correct the data to remove DI contributions is presented...
November 2, 2020: Inorganic Chemistry
#30
JOURNAL ARTICLE
O Škor, L Bicanová, B Wolfesberger, A Fuchs-Baumgartinger, B Ruetgen, M ŠtĚrbová, I Schwendenwein, M Kleiter
In humans B-symptoms refer to systemic symptoms of lymphoma such as fever, weight loss, and night sweats and influence the prognosis of patients. In canine lymphoma, substage B is used to describe any clinical sign observed. Aim of the retrospective study was to compare the prognostic value of substage B with B-symptoms to predict treatment response and survival in canine nodal diffuse large B-cell lymphoma. Affected dogs treated with CHOP chemotherapy between 2008-2019 were included. B-symptoms were defined by weight loss greater than 10% of normal weight, fever and the occurrence of unexplained resting tachypnoea substituted human night sweats...
November 2, 2020: Veterinary and Comparative Oncology
#31
JOURNAL ARTICLE
Stefan Maier, Simon Steinberg, Yudong Cheng, Carl-Friedrich Schön, Mathias Schumacher, Riccardo Mazzarello, Pavlo Golub, Ryky Nelson, Oana Cojocaru-Mirédin, Jean-Yves Raty, Matthias Wuttig
Understanding the nature of chemical bonding in solids is crucial to comprehend the physical and chemical properties of a given compound. To explore changes in chemical bonding in lead chalcogenides (PbX, where X = Te, Se, S, O), a combination of property-, bond-breaking-, and quantum-mechanical bonding descriptors are applied. The outcome of the explorations reveals an electron-transfer-driven transition from metavalent bonding in PbX (X = Te, Se, S) to iono-covalent bonding in β-PbO. Metavalent bonding is characterized by adjacent atoms being held together by sharing about a single electron (ES ≈ 1) and small electron transfer (ET)...
November 2, 2020: Advanced Materials
#32
JOURNAL ARTICLE
J K Akintunde, G O Oyedibu, N J Olanipekun, O A Olaleye
Chronic mixed toxicant exposure has been implicated in the aetiology of lung and heart failure through prolonged free radical generations. This study was carried out to assess the protective effect of naturally occurring phenolic components from Croton zambesicus (400 mg/kg C-ZAMB) leaves against cardiopulmonary toxicity induced by chronic mixed toxicant (0.5 mL EOMABRSL) in rats. Chronic cardiopulmonary injury via oral administration of 0.5 ml EOMABRSL for 98 days (non-withdrawal) and 70 days (withdrawal) caused unhealthy alteration in the levels of oxidative stress biomarkers [malondialdehyde (MDA), reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase]...
April 2021: Cardiovascular Toxicology
#33
JOURNAL ARTICLE
Anne J M R Geijsen, Arve Ulvik, Biljana Gigic, Dieuwertje E Kok, Fränzel J B van Duijnhoven, Andreana N Holowatyj, Stefanie Brezina, Eline H van Roekel, Andreas Baierl, Michael M Bergmann, Jürgen Böhm, Martijn J L Bours, Hermann Brenner, Stéphanie O Breukink, Mary P Bronner, Jenny Chang-Claude, Johannes H W de Wilt, William M Grady, Thomas Grünberger, Tanja Gumpenberger, Esther Herpel, Michael Hoffmeister, Lyen C Huang, Jolanta D Jedrzkiewicz, Eric T P Keulen, Rama Kiblawi, Torsten Kölsch, Janna L Koole, Katharina Kosma, Ewout A Kouwenhoven, Flip M Kruyt, Gry Kvalheim, Christopher I Li, Tengda Lin, Jennifer Ose, T Bartley Pickron, Courtney L Scaife, Peter Schirmacher, Martin A Schneider, Petra Schrotz-King, Marie C Singer, Eric R Swanson, Peter van Duijvendijk, Henk K van Halteren, Moniek van Zutphen, Kathy Vickers, F Jeroen Vogelaar, Evertine Wesselink, Nina Habermann, Alexis B Ulrich, Per M Ueland, Matty P Weijenberg, Andrea Gsur, Cornelia M Ulrich, Ellen Kampman
Background: Folates, including folic acid, may play a dual role in colorectal cancer development. Folate is suggested to be protective in early carcinogenesis but could accelerate growth of premalignant lesions or micrometastases. Whether circulating concentrations of folate and folic acid, measured around time of diagnosis, are associated with recurrence and survival in colorectal cancer patients is largely unknown. Methods: Circulating concentrations of folate, folic acid, and folate catabolites p-aminobenzoylglutamate and p-acetamidobenzoylglutamate were measured by liquid chromatography-tandem mass spectrometry at diagnosis in 2024 stage I-III colorectal cancer patients from European and US patient cohort studies...
October 2020: JNCI Cancer Spectrum
#34
JOURNAL ARTICLE
Saud I Al-Resayes, Mohammad Azam, Agata Trzesowska-Kruszynska, Rafal Kruszynski, Saied M Soliman, Ranjan K Mohapatra, Zahid Khan
A novel Schiff base compound derived from the condensation of 2-hydroxy-1-naphthaldehyde with (1 S ,2 S )-(-)-1,2-diphenylethylenediamine in 2:1 M ratio was reported and investigated by elemental analyses, Fourier transform infrared and NMR spectroscopic studies, and single-crystal X-ray crystallography. Hirshfeld surface analyses were also carried out to measure the various intermolecular contacts controlling the supramolecular topology, suggesting the H···O (7.6%) contacts to be the most significant interactions, whereas the H···H (48...
October 27, 2020: ACS Omega
#35
JOURNAL ARTICLE
Bahareh Naderizadeh, Mehdi Bayat
N-Heterocyclic carbene and phosphine can be labeled as solid σ-donor ligands and can contribute to stable complexes. In addition, the constructed complex can accommodate a wide variety of applications, such as pharmaceutical products. In the light of this, a theoretical analysis was carried out on the existence of metal-drug interactions of group 11 metal ions in coordination with symmetrical unsaturated N-heterocyclic carbenes [NHC(R)(R')] and monodentate phosphine (PR3 ). The R substitutes on N atoms in NHC and phosphines are identical, and R' substitutes are located on two noncarbenic carbon atoms (C4 and C5) in the heterocycle complexes...
October 27, 2020: ACS Omega
#36
JOURNAL ARTICLE
Charles N Agoti, Martin Mutunga, Arnold W Lambisia, Domtila Kimani, Robinson Cheruiyot, Patience Kiyuka, Clement Lewa, Elijah Gicheru, Metrine Tendwa, Khadija Said Mohammed, Victor Osoti, Johnstone Makale, Brian Tawa, Calleb Odundo, Wesley Cheruiyot, Wilfred Nyamu, Wilson Gumbi, Jedidah Mwacharo, Lydia Nyamako, Edward Otieno, David Amadi, Janet Thoya, Angela Karani, Daisy Mugo, Jennifer Musyoki, Horace Gumba, Salim Mwarumba, Bonface M Gichuki, Susan Njuguna, Debra Riako, Shadrack Mutua, John N Gitonga, Yiakon Sein, Brian Bartilol, Shaban J Mwangi, Donwilliams O Omuoyo, John M Morobe, Zaydah R de Laurent, Philip Bejon, Lynette Isabella Ochola-Oyier, Benjamin Tsofa
Background. International recommendations for the control of the coronavirus disease 2019 (COVID-19) pandemic emphasize the central role of laboratory testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent, at scale. The availability of testing reagents, laboratory equipment and qualified staff are important bottlenecks to achieving this. Elsewhere, pooled testing (i.e. combining multiple samples in the same reaction) has been suggested to increase testing capacities in the pandemic period...
2020: Wellcome Open Research
#37
JOURNAL ARTICLE
Rami Lee, Na-Eun Lee, Sun-Hye Choi, Sung Min Nam, Hyoung-Chun Kim, Hyewhon Rhim, Ik-Hyun Cho, Sung-Hee Hwang, Seung-Yeol Nah
Background: Recently, gintonin and gintonin-enriched fraction (GEF) have been isolated from ginseng, a herbal medicine. Gintonin induces [Ca2+ ]i transition in cultured hippocampal neurons and stimulates acetylcholine release through LPA receptor activation. Oral administration of GEF is linked to hippocampus-dependent cognitive enhancement and other neuroprotective effects; however, effects of its long-term administration on hippocampal gene expression remains unknown. Here, we used next-generation sequence (NGS) analysis to examine changes in hippocampal gene expressions after long-term oral administration of GEF...
June 2021: Integrative Medicine Research
#38
JOURNAL ARTICLE
Juan Rizo, David Díaz, Benito Reyes-Trejo, M Josefina Arellano-Jiménez
Methyl parathion (MP) is one of the most neurotoxic pesticides. An inexpensive and reliable one-step degradation method of MP was achieved through an aqueous suspension of copper(I) oxide nanoparticles (NPs). Three different NPs sizes (16, 29 and 45 nm), determined with X-ray diffraction (XRD) and high-resolution transmission electron microscopy (HRTEM), were synthesized using a modified Benedict's reagent. 1 H nuclear magnetic resonance (NMR) results show that the hydrolytic degradation of MP leads to the formation of 4-nitrophenol (4-NPh) as the main product...
2020: Beilstein Journal of Nanotechnology
#39
JOURNAL ARTICLE
Michael R Hass, Brian P Leung
The acronym R.I.O.T., record review, interview, observation, and test, is a well-known tool for conceptualizing a comprehensive assessment. With COVID-19 and the need to provide school psychological services virtually, it is important to reconsider R.I.O.T. in light of the limitations of virtual assessment. We describe the limitations of virtual assessment and argue that in spite of these barriers, the first three elements of R.I.O.T., record review, interviews, and observations, when used systematically, can provide useful comprehensive assessment data...
October 23, 2020: Contemporary School Psychology
#40
JOURNAL ARTICLE
I Tahirou, M O Zara, M L Moustapha, M Kamayé, D Mahamadou, A Ibrahim, M Daou, A Soumana, M L Ibrahim
BACKGROUND: Congenital malaria is a serious and common infection in tropical Africa. It has multiple consequences on the newborn and the mother. OBJECTIVE: The objective of this study is to calculate the prevalence of congenital malaria, describe its clinical signs, and analyze its associated factors. Methodology . It is a cross-sectional and prospective study, conducted at Issaka Gazobi Maternity of Niamey, from June 1 to November 30, 2017. The diagnosis was made by microscopy of a thick and thin blood smear of mother, newborn, and umbilical cord...
2020: International Journal of Pediatrics
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