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допплер, сахарный диабет, нарушение толерантности к глюкоза, ультразвуковое исследование сосудов почки, орбитальный кровоток, диабетичес

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https://www.readbyqxmd.com/read/28820539/a-survey-of-non-communicable-diseases-and-their-risk-factors-among-university-employees-a-single-institutional-study
#1
Emmanuel I Agaba, Maxwell O Akanbi, Patricia A Agaba, Amaka N Ocheke, Zumnan M Gimba, Steve Daniyam, Edith N Okeke
BACKGROUND: The incidence of non-communicable diseases (NCDs) is rising globally, with its attendant morbidity and mortality, especially in developing countries. This study evaluated the prevalence of NCDs and their risk factors among members of a university community. METHODS: All employees of the university were invited to the University health clinic for screening, using the World Health Organisation's STEPwise approach to NCDs. RESULTS: A total of 883 (521; 59...
August 15, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28820416/-ovarian-reserve-and-effectiveness-of-ivf-in-women-of-various-age-groups
#2
A Sayadyan, E Totoyan
The purpose of this study is a comparative assessment of ovarian reserve parameters and the effect of these indices on the features of follicle and oogenesis in women of different age groups. A retrospective analysis of IVF results was conducted in 101 patients aged 21 to 49 years. All patients were divided into 4 groups according to age: I group up to 30 y.o. - 45 women, II group - 31-35 y.o - 14 women, III group - 36-40 y.o. - 26 women, IV Group - 41 or more - 16 women. A low ovarian reserve was found in the majority (84,6%) of women in group III and in all women in group IV...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28820363/incidence-of-perioperative-medical-complications-and-mortality-among-elderly-patients-undergoing-surgery-for-spinal-deformity-analysis-of-3519-patients
#3
Amit Jain, Hamid Hassanzadeh, Varun Puvanesarajah, Eric O Klineberg, Daniel M Sciubba, Michael P Kelly, D Kojo Hamilton, Virginie Lafage, Aaron J Buckland, Peter G Passias, Themistocles S Protopsaltis, Renaud Lafage, Justin S Smith, Christopher I Shaffrey, Khaled M Kebaish
OBJECTIVE Using 2 complication-reporting methods, the authors investigated the incidence of major medical complications and mortality in elderly patients after surgery for adult spinal deformity (ASD) during a 2-year follow-up period. METHODS The authors queried a multicenter, prospective, surgeon-maintained database (SMD) to identify patients 65 years or older who underwent surgical correction of ASD from 2008 through 2014 and had a minimum 2 years of follow-up (n = 153). They also queried a Centers for Medicare & Medicaid Services claims database (MCD) for patients 65 years or older who underwent fusion of 8 or more vertebral levels from 2005 through 2012 (n = 3366)...
August 18, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28820264/iridium-catalyzed-enantioselective-silylation-of-unactivated-c-sp3-h-bonds
#4
Bo Su, John F Hartwig
We report highly enantioselective silylations of unactivated, primary C(sp3)-H bonds. The reactions form dihydrobenzosiloles in high yields with excellent enantioselectivities by functionalization of enantiotopic methyl groups under mild conditions. The reaction is catalyzed by an iridium complex generated from [Ir(COD)OMe]2 and chiral dinitrogen ligands that were recently developed by our group. The C-Si bonds in the enantioenriched dihydrobenzosiloles were further transformed to C-Cl, C-Br, C-I and C-O bonds in final products...
August 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28820253/bioinorganic-chemistry-of-parkinson-s-disease-affinity-and-structural-features-of-cu-i-binding-to-the-full-length-%C3%AE-synuclein-protein
#5
Marco C Miotto, Mayra D Pavese, Liliana Quintanar, Markus Zweckstetter, Christian Griesinger, Claudio O Fernández
Alterations in the levels of copper in brain tissue and formation of α-synuclein (αS)-copper complexes might play a key role in the amyloid aggregation of αS and the onset of Parkinson's disease (PD). Recently, we demonstrated that formation of the high-affinity Cu(I) complex with the N-terminally acetylated form of the protein αS substantially increases and stabilizes local conformations with α-helical secondary structure and restricted motility. In this work, we performed a detailed NMR-based structural characterization of the Cu(I) complexes with the full-length acetylated form of its homologue β-synuclein (βS), which is colocalized with αS in vivo and can bind copper ions...
August 18, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28819698/sublethal-effects-of-pyrethroid-and-neonicotinoid-insecticides-on-iphiseiodes-zuluagai-denmark-and-muma-mesostigmata-phytoseiidae
#6
Odimar Zanuzo Zanardi, Gabriela Pavan Bordini, Aline Aparecida Franco, Cynthia Renata Oliveira Jacob, Pedro Takao Yamamoto
The predator mite Iphiseiodes zuluagai Denmark & Muma is an important biological-control agent of mite pests, and it is one of the most common species found in citrus orchards. This study assessed, under laboratory conditions, the toxicity and duration of the harmful effects of five insecticides, the three pyrethroids deltamethrin, esfenvalerate and lambda-cyhalothrin, and the two neonicotinoids imidacloprid and thiamethoxam on I. zuluagai. Furthermore, we estimated the life-table parameters of the predator...
August 17, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28818869/clinical-risks-and-healthcare-utilization-of-haematopoietic-cell-transplantation-for-sickle-cell-disease-in-the-u-s-using-merged-databases
#7
Staci D Arnold, Ruta Brazauskas, Naya He, Yimei Li, Richard Aplenc, Zhezhen Jin, Matt Hall, Yoshiko Atsuta, Jignesh Dalal, Theresa Hahn, Nandita Khera, Carmem Bonfim, Navneet S Majhail, Miguel Angel Diaz, Cesar O Freytes, William A Wood, Bipin M Savani, Rammurti T Kamble, Susan Parsons, Ibrahim Ahmed, Keith Sullivan, Sara Beattie, Christopher Dandoy, Reinhold Munker, Susana Marino, Menachem Bitan, Hisham Abdel-Azim, Mahmoud Aljurf, Richard F Olsson, Sarita Joshi, Dave Buchbinder, Michael J Eckrich, Shahrukh Hashmi, Hillard Lazarus, David I Marks, Amir Steinberg, Ayman Saad, Usama Gergis, Lakshmanan Krishnamurti, Allistair Abraham, Hemalatha G Rangarajan, Mark Walters, Joseph Lipscomb, Wael Saber, Prakash Satwani
Allogeneic hematopoietic cell transplant advances for sickle cell disease improve outcomes, but limited healthcare utilization analysis exists. We hypothesized that early transplant (age < 10 years) improves outcomes and decreases healthcare utilization compared to late. We performed a retrospective study of US children transplanted for sickle cell during 2000-2013 using two large databases. Univariate and Cox models estimated associations between demographics, sickle cell severity, and transplant-related variables on mortality and chronic graft versus-host-disease; while, Wilcoxon, Kruskal-Wallis, or linear trend tests estimated against healthcare utilization...
August 17, 2017: Haematologica
https://www.readbyqxmd.com/read/28818778/potential-effect-of-compounds-isolated-from-coffea-arabica-against-uv-b-induced-skin-damage-by-protecting-fibroblast-cells
#8
Yong-Hun Cho, Ashutosh Bahuguna, Han-Hyuk Kim, Dong-In Kim, Hyeon-Jeong Kim, Jae-Myo Yu, Hyun-Gug Jung, Jae-Yoon Jang, Jae-Hoon Kwak, Geun-Hye Park, O-Jun Kwon, Young Je Cho, Jeong Yeon An, Cheorun Jo, Sun Chul Kang, Bong-Jeun An
Ultraviolet (UV) radiation has adverse effects on extracellular matrix (ECM) proteins, leading to formation of wrinkles a hallmark of premature skin aging. The adverse effects of UV radiation are associated with induction of matrix metalloproteinases (MMPs) expression and degradation of collagen and elastin. The present study investigated anti-wrinkle effects of chlorogenic acid (CGA), pyrocatechol (PC) and 3,4,5-tricaffeoyl quinic acid (TCQ), isolated from beans of Coffea arabica, against UV-B stimulated mouse fibroblast cells (CCRF) by measuring expression levels of MMP-1, 3, 9, and type-I procollagen...
August 9, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28818602/operational-modelling-of-bigeye-tuna-thunnus-obesus-spatial-dynamics-in-the-indonesian-region
#9
P Lehodey, I Senina, T A Wibawa, O Titaud, B Calmettes, A Conchon, B Tranchant, P Gaspar
With INDESO, Indonesia has implemented a system for the monitoring and management of its tuna resources. Despite increasing catch, very few is known about the dynamics and real abundance of tuna species in the Indonesian waters and adjacent oceanic regions. The SEAPODYM model was implemented in an operational chain of production for the Indonesian region to simulate tuna spatial dynamics in realtime. This challenging objective imposed developing a global scale model at coarse resolution to provide initial and boundaries conditions of the regional model...
August 14, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28818448/elucidation-of-a-carboxylate-o-methyltransferase-ncmp-in-nocamycin-biosynthetic-pathway
#10
Xuhua Mo, Chun Gui, Qingji Wang
Nocamycins belong to the tetramic acid family natural products and show potent antimicrobial activity. Recently, the biosynthetic gene cluster of nocamycin was identified from the rare actinomycete Saccharothrix syringae and an S-adenosylmethionine (SAM) dependent methyltransferase gene NcmP was found to be located within the gene cluster. In this report, the methyltransferase gene NcmP was disrupted and a new nocamycin intermediate nocamycin E was isolated from the mutant strain. Meanwhile, NcmP was heterologously expressed in Escherichia coli BL21 (DE3) and biochemically characterized as a carboxylate O-methyltransferase in nocamycin biosynthetic pathway...
August 7, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28818341/harnessing-the-power-of-genomics-to-secure-the-future-of-seafood
#11
REVIEW
Louis Bernatchez, Maren Wellenreuther, Cristián Araneda, David T Ashton, Julia M I Barth, Terry D Beacham, Gregory E Maes, Jann T Martinsohn, Kristina M Miller, Kerry A Naish, Jennifer R Ovenden, Craig R Primmer, Young Suk Ho, Nina O Therkildsen, Ruth E Withler
Best use of scientific knowledge is required to maintain the fundamental role of seafood in human nutrition. While it is acknowledged that genomic-based methods allow the collection of powerful data, their value to inform fisheries management, aquaculture, and biosecurity applications remains underestimated. We review genomic applications of relevance to the sustainable management of seafood resources, illustrate the benefits of, and identify barriers to their integration. We conclude that the value of genomic information towards securing the future of seafood does not need to be further demonstrated...
August 14, 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/28818275/electromagnetic-fields-may-act-via-calcineurin-inhibition-to-suppress-immunity-thereby-increasing-risk-for-opportunistic-infection-conceivable-mechanisms-of-action
#12
P R Doyon, O Johansson
While a good number of studies have demonstrated that modern, man-made ambient electromagnetic fields can have both stimulatory and inhibitory effect on immune system function, the precise mechanisms have yet to be completely elucidated. It is hypothesized here that, depending on the parameters, one of the means by which long-term electromagnetic field exposure has the potential to eventually lead to immunosuppression is via downstream inhibition of the enzyme calcineurin - a protein phosphatase, which activates the T-cells of the immune system and can be blocked by pharmaceutical agents...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28818208/catecholamine-dependent-%C3%AE-adrenergic-signaling-in-a-pluripotent-stem-cell-model%C3%A2-of-takotsubo-cardiomyopathy
#13
Thomas Borchert, Daniela Hübscher, Celina I Guessoum, Tuan-Dinh D Lam, Jelena R Ghadri, Isabel N Schellinger, Malte Tiburcy, Norman Y Liaw, Yun Li, Jan Haas, Samuel Sossalla, Mia A Huber, Lukas Cyganek, Claudius Jacobshagen, Ralf Dressel, Uwe Raaz, Viacheslav O Nikolaev, Kaomei Guan, Holger Thiele, Benjamin Meder, Bernd Wollnik, Wolfram-Hubertus Zimmermann, Thomas F Lüscher, Gerd Hasenfuss, Christian Templin, Katrin Streckfuss-Bömeke
BACKGROUND: Takotsubo syndrome (TTS) is characterized by an acute left ventricular dysfunction and is associated with life-threating complications in the acute phase. The underlying disease mechanism in TTS is still unknown. A genetic basis has been suggested to be involved in the pathogenesis. OBJECTIVES: The aims of the study were to establish an in vitro induced pluripotent stem cell (iPSC) model of TTS, to test the hypothesis of altered β-adrenergic signaling in TTS iPSC-cardiomyocytes (CMs), and to explore whether genetic susceptibility underlies the pathophysiology of TTS...
August 22, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28818144/refining-selection-for-elite-troops-by-predicting-military-training-outcome
#14
Susan Vrijkotte, Romain Meeusen, Bart Roelands, Sabine Kubesch, Olivier Mairesse, Guy de Schutter, Nathalie Pattyn
INTRODUCTION: Paratrooper training courses are very demanding, leading to a high number of drop-outs, despite existing selection criteria. This study investigated physiological, neuropsychological, and subjective data of completers and drop-outs during paratrooper training to identify potential predictive indices. METHODS: Tested were 24 paratrooper soldiers before (t0), after 8 wk (t1), and at the end of a 12-wk training camp (t2). There were 11 soldiers who completed the course and 13 dropped out...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818061/estimating-correlation-between-multivariate-longitudinal-data-in-the-presence-of-heterogeneity
#15
Feng Gao, J Philip Miller, Chengjie Xiong, Jingqin Luo, Julia A Beiser, Ling Chen, Mae O Gordon
BACKGROUND: Estimating correlation coefficients among outcomes is one of the most important analytical tasks in epidemiological and clinical research. Availability of multivariate longitudinal data presents a unique opportunity to assess joint evolution of outcomes over time. Bivariate linear mixed model (BLMM) provides a versatile tool with regard to assessing correlation. However, BLMMs often assume that all individuals are drawn from a single homogenous population where the individual trajectories are distributed smoothly around population average...
August 17, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28817437/surgicopathological-quality-control-and-protocol-adherence-to-lymphadenectomy-in-the-critics-gastric-cancer-trial
#16
Yvette H M Claassen, Wobbe O de Steur, Henk H Hartgrink, Johan L Dikken, Johanna W van Sandick, Nicole C T van Grieken, Annemiek Cats, Anouk K Trip, Edwin P M Jansen, Willemina M Meershoek-Klein Kranenbarg, Jeffrey P B M Braak, Hein Putter, Mark I van Berge Henegouwen, Marcel Verheij, Cornelis J H van de Velde
OBJECTIVE: The purpose of this study was to evaluate surgicopathological quality and protocol adherence for lymphadenectomy in the CRITICS trial. SUMMARY OF BACKGROUND DATA: Surgical quality assurance is a key element in multimodal studies for gastric cancer. In the multicenter CRITICS trial (ChemoRadiotherapy after Induction chemotherapy In Cancer of the Stomach), patients with resectable gastric cancer were randomized for preoperative chemotherapy, followed by gastrectomy with a D1+ lymphadenectomy (removal of stations 1 to 9 and 11), followed by either chemotherapy or chemoradiotherapy...
August 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28815904/comparative-in-vitro-study-on-cytotoxicity-of-recombinant-%C3%AE-hairpin-peptides
#17
Denis V Kuzmin, Anna A Emelianova, Mariana B Kalashnikova, Pavel V Panteleev, Sergey V Balandin, Ekaterina O Serebrovskaya, Oksana Yu Belogurova-Ovchinnikova, Tatiana V Ovchinnikova
Natural antimicrobial peptides (AMPs) are important components of the innate immune system with a wide spectrum of biological activity. In this study, we investigated the cytotoxic effect of three recombinant β-hairpin cationic AMPs: arenicin-1 from the polychaeta Arenicola marina, tachyplesin I from the horseshoe crab Tachypleus tridentatus, and gomesin from the spider Acanthoscurria gomesiana. All the three β-hairpin AMPs were overexpressed in E. coli. Different cell lines were incubated with various concentrations of the investigated AMPs in order to evaluate their cytotoxic activity...
August 16, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28815804/octadentate-picolinic-acid-based-bispidine-ligand-for-radiometal-ions
#18
Peter Comba, Una Jermilova, Chris Orvig, Brian O Patrick, Caterina F Ramogida, Katharina Rück, Christina Schneider, Miriam Starke
The synthesis of the octadentate bispidine ligand H2bispa2 bearing two picolinic acid pendant arms and its coordination chemistry with metal ions with radionuclides relevant for nuclear medicine, i.e. indium(III) (111In), lutetium(III) (177Lu) and lanthanum(III) (as surrogate for 225Ac), are reported. The non-radioactive metal complexes of the N6O2-type bispa ligand were characterized by 1H and 13C nuclear magnetic resonance spectroscopy, elemental analysis, mass spectrometry and single crystal X-ray analysis...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815548/persistent-increase-in-tnf-and-il-1-markers-in-severe-mental-disorders-suggests-trait-related-inflammation-a-one-year-follow-up-study
#19
R H Mørch, I Dieset, A Faerden, S Hope, M Aas, M Nerhus, E S Gardsjord, M Haram, R S Falk, I Joa, G Morken, I Agartz, P Aukrust, S Djurovic, I Melle, T Ueland, O A Andreassen
OBJECTIVE: We evaluated if plasma levels of inflammatory markers are persistently altered in severe mental disorders with psychotic symptoms or associated with state characteristics in a longitudinal study. METHODS: Soluble tumor necrosis factor receptor 1 (sTNF-R1), interleukin-1 receptor antagonist (IL-1Ra), von Willebrand factor (VWF), and osteoprotegerin (OPG) were measured in schizophrenia (n = 69) and affective (n = 55) spectrum patients at baseline and at one-year follow-up, and compared to healthy controls (HC) (n = 92) with analysis of covariance...
August 16, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28815547/adjustable-mini-sling-compared-to-conventional-mid-urethral-slings-in-women-with-urinary-incontinence-a-randomized-controlled-trial
#20
Martin Rudnicki, Katarina von Bothmer-Ostling, Anja Holstad, Claes Magnusson, Memona Majida, Constanze Merkel, Jens Prien, Ulf Jakobsson, Pia Teleman
INTRODUCTION: The primary aim was to compare the objective and subjective outcomes and short-term complication rates of an adjustable single-incision mini-sling (SIMS) versus standard mid-urethral slings (SMUS). The secondary aim was reporting pain perception and complications at one-year follow-up. MATERIAL AND METHODS: The study was designed as a multicenter prospective randomized trial where women were included by eight centers in Denmark, Norway and Sweden. The trial was registered at ClinicalTrials...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
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