keyword
MENU ▼
Read by QxMD icon Read
search

допплер, сахарный диабет, нарушение толерантности к глюкоза, ультразвуковое исследование сосудов почки, орбитальный кровоток, диабетичес

keyword
https://www.readbyqxmd.com/read/28231016/construction-of-bisbenzofuro-2-3-b-3-2-e-pyridines-by-palladium-catalyzed-double-intramolecular-oxidative-c-h-c-h-coupling
#1
Hiroyuki Kaida, Tsuyoshi Goya, Yuji Nishii, Koji Hirano, Tetsuya Satoh, Masahiro Miura
The palladium-catalyzed intramolecular oxidative C-H/C-H coupling of 2-aryloxypyridines as challenging substrates is investigated to construct an important class of N,O-mixed heteroacenes, i.e. benzofuropyridines. It is found that 2,6-diaryloxypyridines efficiently undergo double cyclization to provide bisbenzofuro[2,3-b:3',2'-e]pyridines of interest in materials chemistry.
February 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28230982/synthesis-of-%C3%AE-1-2-linked-6-deoxy-l-altropyranose-oligosaccharides-via-gold-i-catalyzed-glycosylation-of-a-ortho-hexynylbenzoate-donor
#2
Zhengnan Shen, Hani Mobarak, Wei Li, Göran Widmalm, Biao Yu
The β-(1-2)-linked 6-deoxy-L-altropyranose di- to penta-saccharides 2-5, relevant to the O-antigen of the infectious Yersinia enterocolitica O:3, were synthesized for the first time. The challenging 1,2-cis-altropyranosyl linkage was assembled effectively via glycosylation with 2-O-benzyl-3,4-di-O-benzoyl-6-deoxy-L-altropyranosyl ortho-hexynylbenzoate (7) under the catalysis of PPh3AuNTf2. NMR and molecular modeling studies showed that the pentasaccharide (5) adopted a left-handed helical conformation.
February 23, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28230826/modifying-effects-of-5-azacytidine-on-metal-containing-proteins-profile-in-guerin-carcinoma-with-different-sensitivity-to-cytostatics
#3
V F Chekhun, Y V Lozovska, L A Naleskina, T V Borikun, A P Burlaka, I N Todor, D V Demash, T M Yalovenko, T V Zadvornyi, A O Pavlova, D M Storchay, N Yu Lukianova
AIM: To assess the influence of the treatment with 5-azacytidine (5-aza) on the profile of metal-containing proteins and factors of their regulation in Guerin carcinoma cells in vivo. MATERIALS AND METHODS: The study was conducted on Wistar rats transplanted with wild-type Guerin carcinoma (Guerin/WT) and its strains resistant to cisplatin (Guerin/CP) or doxorubicin (Guerin/Dox). Animals were distributed in 6 groups treated with 5-aza and control animals without treatment...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28230758/quantitative-determination-of-stilbenoids-and-dihydroisocoumarins-in-shorea-roxburghii-and-evaluation-of-their-hepatoprotective-activity
#4
Kiyofumi Ninomiya, Saowanee Chaipech, Yusuke Kunikata, Ryohei Yagi, Yutana Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa
A simultaneous quantitative analytical method for 13 stilbenoids including (-)-hopeaphenol (1), (+)-isohopeaphenol (2), hemsleyanol D (3), (-)-ampelopsin H (4), vaticanols A (5), E (6), and G (7), (+)-α-viniferin (8), pauciflorol A (9), hopeafuran (10), (-)-balanocarpol (11), (-)-ampelopsin A (12), and trans-resveratrol 10-C-β-d-glucopyranoside (13), and two dihydroisocoumarins, phayomphenols A₁ (14) and A₂ (15) in the extract of Shorea roxburghii (dipterocarpaceae) was developed. According to the established protocol, distributions of these 15 polyphenols (1-15) in the bark and wood parts of S...
February 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28230746/oxidation-of-5-chloromethylfurfural-cmf-to-2-5-diformylfuran-dff
#5
Ana I Vicente, Jaime A S Coelho, Svilen P Simeonov, Hristina I Lazarova, Margarita D Popova, Carlos A M Afonso
2,5-Diformylfuran (DFF) is an important biorenewable building block, namely for the manufacture of new polymers that may replace existing materials derived from limited fossil fuel resources. The current reported methods for the preparation of DFF are mainly derived from the oxidation of 5-hydroxymethylfurfural (HMF) and, to a lesser extent, directly from fructose. 5-Chloromethylfurfural (CMF) has been considered an alternative to HMF as an intermediate building block due to its advantages regarding stability, polarity, and availability from glucose and cellulose...
February 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28230738/clinical-implications-of-20-hydroxyeicosatetraenoic-acid-in-the-kidney-liver-lung-and-brain-an-emerging-therapeutic-target
#6
REVIEW
Osama H Elshenawy, Sherif M Shoieb, Anwar Mohamed, Ayman O S El-Kadi
Cytochrome P450-mediated metabolism of arachidonic acid (AA) is an important pathway for the formation of eicosanoids. The ω-hydroxylation of AA generates significant levels of 20-hydroxyeicosatetraenoic acid (20-HETE) in various tissues. In the current review, we discussed the role of 20-HETE in the kidney, liver, lung, and brain during physiological and pathophysiological states. Moreover, we discussed the role of 20-HETE in tumor formation, metabolic syndrome and diabetes. In the kidney, 20-HETE is involved in modulation of preglomerular vascular tone and tubular ion transport...
February 20, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28230316/quantitative-cognitive-test-characterization-of-reconnectable-implantable-fiber-optic-neurointerfaces-for-optogenetic-neurostimulation
#7
I V Fedotov, O I Ivashkina, M S Pochechuev, M A Roshchina, K A Toropova, A B Fedotov, K V Anokhin, A M Zheltikov
Cognitive tests on representative groups of freely behaving transgenic mice are shown to enable a quantitative characterization of reconnectable implantable fiber-optic neurointerfaces for optogenetic neurostimulation. A systematic analysis of such tests provides a robust quantitative measure for the cognitive effects induced by fiber-optic neurostimulation, validating the performance of fiber-optic neurointerfaces for long-term optogenetic brain stimulations and showing no statistically significant artifacts in the behavior of transgenic mice due to interface implantation...
February 23, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28230292/age-related-changes-in-pain-sensitivity-in-healthy-humans-a-systematic-review-with-meta-analysis
#8
REVIEW
H El Tumi, M I Johnson, P B F Dantas, M J Maynard, O A Tashani
: Literature suggests that pain perception diminishes in old age. The most recent review used search strategies conducted over a decade ago and concluded that study findings were equivocal. The aim of this systematic review, with meta-analysis, was to determine age-related changes in pain sensitivity in healthy pain-free adults, children and adolescents. A search of PubMed, Science Direct, and PsycINFO identified studies that compared pain sensitivity response to noxious stimuli at different time points in the lifespan of healthy individuals...
February 23, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28230202/ecosystem-composition-controls-the-fate-of-rare-earth-elements-during-incipient-soil-genesis
#9
Dragos G Zaharescu, Carmen I Burghelea, Katerina Dontsova, Jennifer K Presler, Raina M Maier, Travis Huxman, Kenneth J Domanik, Edward A Hunt, Mary K Amistadi, Emily E Gaddis, Maria A Palacios-Menendez, Maria O Vaquera-Ibarra, Jon Chorover
The rare earth elements (REE) are increasingly important in a variety of science and economic fields, including (bio)geosciences, paleoecology, astrobiology, and mining. However, REE distribution in early rock-microbe-plant systems has remained elusive. We tested the hypothesis that REE mass-partitioning during incipient weathering of basalt, rhyolite, granite and schist depends on the activity of microbes, vascular plants (Buffalo grass), and arbuscular mycorrhiza. Pore-water element abundances revealed a rapid transition from abiotic to biotic signatures of weathering, the latter associated with smaller aqueous loss and larger plant uptake...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230074/lack-of-resistance-development-in-bemisia-tabaci-to-isaria-fumosorosea-after-multiple-generations-of-selection
#10
Tianni Gao, Zhaolei Wang, Yü Huang, Nemat O Keyhani, Zhen Huang
The emergence of insecticide resistant insect pests is of significant concern worldwide. The whitefly, Bemisia tabaci, is an important agricultural pest and has shown incredible resilience developing resistance to a number of chemical pesticides. Entomopathogenic fungi such as Isaria fumosorosea offer an attractive alternative to chemical pesticides for insect control, and this fungus has been shown to be an effective pathogen of B. tabaci. Little is known concerning the potential for the development of resistance to I...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229922/mandevilla-longiflora-desf-pichon-improves-airway-inflammation-in-a-murine-model-of-allergic-asthma
#11
Danielle Ayr Tavares de Almeida, Suellen Iara Guirra Rosa, Thais Campos Dias da Cruz, Eduarda Pavan, Amílcar Sabino Damazo, Ilsamar Mendes Soares, Sérgio Donizeti Ascêncio, Antonio Macho, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Mandevilla longiflora, popularly known as "velame" in central Brazil, is a subshrub and widely distributed in South America. Its xylopodium is used in the form of a decoction or infusion to treat inflammation and other ailments. AIM OF THE STUDY: This study aimed to evaluate the anti-inflammatory potential of M. longiflora in an in vivo model of ovalbumin-induced immediate hypersensitivity, identifying its effects on leukocyte infiltration, IgE and LTB4 levels, and Th2 cytokine production...
February 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28229516/a-direct-link-from-the-gas-to-the-condensed-phase-a-rotational-spectroscopic-study-of-2-2-2-trifluoroethanol-trimers
#12
Javix Thomas, Nathan A Seifert, Wolfgang Jäger, Yunjie Xu
Rotational spectra of the three most stable conformers (I, II, III) of the ternary 2,2,2-trifluoroethanol (TFE) cluster were measured using Fourier transform microwave spectrometers, and unambiguously assigned with the aid of ab initio calculations. The most stable conformer, I, contains one trans-TFE subunit which is unstable in its isolated gas phase form. The study offers new insights into how the trans conformation is stabilized in TFE clusters of increasing size, and eventually becomes a dominant conformation in the liquid phase...
February 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28229134/magnetic-microkayaks-propulsion-of-microrods-precessing-near-a-surface-by-kilohertz-frequency-rotating-magnetic-fields
#13
L O Mair, B A Evans, A Nacev, P Y Stepanov, R Hilaman, S Chowdhury, S Jafari, W Wang, B Shapiro, I N Weinberg
Surface-swimming nano- and micromotors hold significant potential for on-chip mixing, flow generation, sample manipulation, and microrobotics. Here we describe rotating microrods magnetized nearly orthogonally to their long axes. When actuated near a solid surface, these microrods demonstrate precessing motion, with rods describing a double cone similar to the motion of a kayaker's paddle. The precessing motion induces translation. At 1 kHz, these "microkayaks" move at translational velocities of ≈14 μm s(-1) and generate advective flows up to 10 μm s(-1)...
February 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28229133/towards-enhanced-optical-sensor-performance-seira-and-sers-with-plasmonic-nanostars
#14
O Bibikova, J Haas, A I López-Lorente, A Popov, M Kinnunen, I Meglinski, B Mizaikoff
We report the preparation and characterization of plasmonic chip-based systems comprising self-assembled gold nanostars at silicon substrates that enable concomitantly enhanced Raman (surface enhanced Raman spectroscopy; SERS) and mid-infrared (surface enhanced infrared reflection or absorption spectroscopy; SEIRA) spectral signatures. The high-aspect-ratio structure of gold nanostars provides an increased number of hot spots at their surface, which results in an electric field enhancement around the nanomaterial...
February 23, 2017: Analyst
https://www.readbyqxmd.com/read/28228594/the-b-cell-response-to-foot-and-mouth-disease-virus-in-cattle-following-sequential-vaccination-with-multiple-serotypes
#15
Clare F J Grant, B Veronica Carr, Abhay Kotecha, Erwin van den Born, David I Stuart, John A Hammond, Bryan Charleston
Foot-and mouth disease virus is a highly contagious viral disease. Antibodies are pivotal in providing protection against FMDV infection. Serological protection against one FMDV serotype doesn't confer inter-serotypic protection. However, some historical data have shown inter-serotypic protection can be induced following sequential FMDV challenge with multiple FMDV serotypes. In this study we have investigated the kinetics of the FMDV-specific antibody secreting cell response following homologous and heterologous inactivated FMDV vaccination regimes...
February 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28228546/a-minimal-actomyosin-based-model-predicts-the-dynamics-of-filopodia-on-neuronal-dendrites
#16
Olena O Marchenko, Sulagna Das, Ji Yu, Igor L Novak, Vladimir I Rodionov, Nadia Efimova, Tatyana Svitkina, Charles W Wolgemuth, Leslie M Loew
Dendritic filopodia are actin-filled dynamic subcellular structures that sprout on neuronal dendrites during neurogenesis. The exploratory motion of the filopodia is crucial for synaptogenesis but the underlying mechanisms are poorly understood. To study the filopodial motility, we collected and analyzed image data on filopodia in cultured rat hippocampal neurons. We hypothesized that mechanical feedback among the actin retrograde flow, myosin activity and substrate adhesion gives rise to various filopodial behaviors...
February 22, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28228542/accelerated-simulation-of-evolutionary-trajectories-in-origin-fixation-models
#17
Ashley I Teufel, Claus O Wilke
We present an accelerated algorithm to forward-simulate origin-fixation models. Our algorithm requires, on average, only about two fitness evaluations per fixed mutation, whereas traditional algorithms require, per one fixed mutation, a number of fitness evaluations of the order of the effective population size, Ne Our accelerated algorithm yields the exact same steady state as the original algorithm but produces a different order of fixed mutations. By comparing several relevant evolutionary metrics, such as the distribution of fixed selection coefficients and the probability of reversion, we find that the two algorithms behave equivalently in many respects...
February 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28228480/a-stable-but-reversible-integrated-surrogate-reporter-for-assaying-crispr-cas9-stimulated-homology-directed-repair
#18
Yahong Wen, Grace Liao, Thomas Pritchard, Ting-Ting Zhao, Jon P Connelly, Shondra M Pruett-Miller, Valerie Blanc, Nicholas O Davidson, Blair B Madison
The discovery and application of CRISPR/Cas9 technology for genome editing has greatly accelerated targeted mutagenesis in a variety of organisms. CRISPR/Cas9-mediated site-specific cleavage is typically exploited for the generation of insertions or deletions (indels) following aberrant dsDNA repair via the endogenous non-homology end-joining (NHEJ) pathway, or alternatively, for enhancing homology directed repair (HDR) to facilitate the generation of a specific mutation (or knock-in). However, there is a need for efficient cellular assays that can measure Cas9/guide RNA (gRNA) activity...
February 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28228478/an-engineered-tgf-%C3%AE-monomer-that-functions-as-a-dominant-negative-to-block-tgf-%C3%AE-signaling
#19
Sun Kyung Kim, Lindsey Barron, Cynthia S Hinck, Elyse M Petrunak, Kristin E Cano, Avinash Thangirala, Brian Iskra, Molly Brothers, Machell Vonberg, Belinda Leal, Blair Richter, Ravindra Kodali, Alex B Taylor, Shoucheng Du, Christopher O Barnes, Traian Sulea, Guillermo Calero, P John Hart, Matthew J Hart, Borries Demeler, Andrew P Hinck
The transforming growth factor beta isoforms, TGF-β1, -β2, and -β3 are small secreted homodimeric signaling proteins with essential roles in regulating the adaptive immune system and maintaining the extracellular matrix. However, dysregulation of the TGF-β pathway is responsible for promoting the progression of several human diseases, including cancer and fibrosis. In spite of the known importance of TGF-βs in promoting disease progression, no inhibitors have been approved for use in humans. Herein, we describe an engineered TGF-β monomer, lacking the heel helix, a structural motif essential for binding the TGF-β type I receptor, TβRI, but dispensible for binding the other receptor required for TGF-β signaling, the TGF-β type II receptor, TβRII, as an alternative therapeutic modality for blocking TGF-β signaling in humans...
February 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28228257/t-regulatory-cells-support-plasma-cell-populations-in-the-bone-marrow
#20
Arielle Glatman Zaretsky, Christoph Konradt, Fabien Dépis, James B Wing, Radhika Goenka, Daniela Gomez Atria, Jonathan S Silver, Sunglim Cho, Amaya I Wolf, William J Quinn, Julie B Engiles, Dorothy C Brown, Daniel Beiting, Jan Erikson, David Allman, Michael P Cancro, Shimon Sakaguchi, Li-Fan Lu, Christophe O Benoist, Christopher A Hunter
Long-lived plasma cells (PCs) in the bone marrow (BM) are a critical source of antibodies after infection or vaccination, but questions remain about the factors that control PCs. We found that systemic infection alters the BM, greatly reducing PCs and regulatory T (Treg) cells, a population that contributes to immune privilege in the BM. The use of intravital imaging revealed that BM Treg cells display a distinct behavior characterized by sustained co-localization with PCs and CD11c-YFP(+) cells. Gene expression profiling indicated that BM Treg cells express high levels of Treg effector molecules, and CTLA-4 deletion in these cells resulted in elevated PCs...
February 21, 2017: Cell Reports
keyword
keyword
83825
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"