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https://www.readbyqxmd.com/read/29145701/tnf-antagonists-killing-two-birds-with-one-biologic-stone
#1
EDITORIAL
Joan M Bathon, Jon T Giles, Daniel H Solomon
Forty years have passed since it was first recognized that patients with autoimmune rheumatic disease have an increased risk of fatal and non-fatal cardiovascular (CV) events (1) Although initial reports focused on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), similar findings were verified subsequently in patients with psoriasis (Ps) and/or psoriatic arthritis (PsA) and spondyloarthritis. An early feature of the atherosclerotic lesion is infiltration with inflammatory cells, particularly monocytes/macrophages, and the presence of these cells in mature plaque elevates the risk of plaque rupture and thrombosis (2)...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29145649/single-molecule-compaction-of-megabase-long-chromatin-molecules-by-multivalent-cations
#2
Anatoly Zinchenko, Nikolay V Berezhnoy, Sai Wang, William M Rosencrans, Nikolay Korolev, Johan R C van der Maarel, Lars Nordenskiöld
To gain insight into the conformational properties and compaction of megabase-long chromatin molecules, we reconstituted chromatin from T4 phage DNA (165 kb) and recombinant human histone octamers (HO). The unimolecular compaction, induced by divalent Mg2+ or tetravalent spermine4+ cations, studied by single-molecule fluorescence microscopy (FM) and dynamic light scattering (DLS) techniques, resulted in the formation of 250-400 nm chromatin condensates. The compaction on this scale of DNA size is comparable to that of chromatin topologically associated domains (TAD) in vivo...
November 14, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29145625/msignaturedb-a-database-for-deciphering-mutational-signatures-in-human-cancers
#3
Po-Jung Huang, Ling-Ya Chiu, Chi-Ching Lee, Yuan-Ming Yeh, Kuo-Yang Huang, Cheng-Hsun Chiu, Petrus Tang
Cancer is a genetic disease caused by somatic mutations; however, the understanding of the causative biological processes generating these mutations is limited. A cancer genome bears the cumulative effects of mutational processes during tumor development. Deciphering mutational signatures in cancer is a new topic in cancer research. The Wellcome Trust Sanger Institute (WTSI) has categorized 30 reference signatures in the COSMIC database based on the analyses of ∼10 000 sequencing datasets from TCGA and ICGC...
November 14, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29145620/head-and-neck-cancer-in-hong-kong
#4
Wai Tong Ng, Edwin C Y Wong, Victor H F Lee, Jimmy Y W Chan, Anne W M Lee
Head and neck cancer is a major cause of morbidity and mortality in Hong Kong. HNC is well-known for its heterogeneity in epidemiology, clinical behavior, clinic-pathological features and patient characteristics. Treatment strategies for this heterogeneous disease vary greatly in different parts of the world, depending on availability of resources, local expertise and experience. Extensive research in head and neck cancer, particularly nasopharyngeal carcinoma, has been conducted in Hong Kong in the past few decades...
November 14, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29145595/synchrony-weather-and-cycles-in-southern-pine-beetle-coleoptera-curculionidae
#5
John D Reeve
Spatial synchrony and cycles are common features of forest insect pests, but are often studied as separate phenomenon. Using time series of timber damage caused by Dendroctonus frontalis Zimmermann (Coleoptera: Curculionidae) (southern pine beetle) in 10 states within the southern United States, this study examines synchrony in D. frontalis abundance, the synchronizing effects of temperature extremes, and the evidence for shared cycles among state populations. Cross-correlation and cluster analyses are used to quantify synchrony across a range of geographic distances and to identify groups of states with synchronous dynamics...
November 14, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29145575/validity-of-the-somatic-symptom-disorder-b-criteria-scale-ssd-12-in-primary-care
#6
Anne Toussaint, Bernhard Riedl, Simon Kehrer, Antonius Schneider, Bernd Löwe, Klaus Linde
Aim: The Somatic Symptom Disorder-B Criteria Scale (SSD-12) assesses the psychological features of DSM-5 somatic symptom disorder. The purpose of the current study was to investigate the psychometric characteristics and validity of the 12-item instrument to demonstrate its suitability in primary care. Method: The study was designed as a cross-sectional survey set in five primary care practices from Munich, Germany (n = 501, 52.0% female, mean age 47 ± 16 years)...
November 13, 2017: Family Practice
https://www.readbyqxmd.com/read/29145509/untargeted-mass-spectrometry-discloses-plasma-solute-levels-poorly-controlled-by-hemodialysis
#7
Tammy L Sirich, Pavel A Aronov, Jonathan Fullman, Khanh Nguyen, Natalie S Plummer, Timothy W Meyer
Many solutes have been reported to remain at higher plasma levels relative to normal than the standard index solute urea in hemodialysis patients. Untargeted mass spectrometry was employed to compare solute levels in plasma and plasma ultrafiltrate of hemodialysis patients and normal subjects. Quantitative assays were employed to check the accuracy of untargeted results for selected solutes and additional measurements were made in dialysate and urine to estimate solute clearances and production. Comparison of peak areas indicated that many solutes accumulated to high levels in hemodialysis patients, with average peak areas in plasma ultrafiltrate of dialysis patients being more than 100 times greater than those in normals for 123 features...
2017: PloS One
https://www.readbyqxmd.com/read/29145503/zinc-sulfate-contributes-to-promote-telomere-length-extension-via-increasing-telomerase-gene-expression-telomerase-activity-and-change-in-the-tert-gene-promoter-cpg-island-methylation-status-of-human-adipose-derived-mesenchymal-stem-cells
#8
Raheleh Farahzadi, Ezzatollah Fathi, Seyed Alireza Mesbah-Namin, Nosratollah Zarghami
The use of mesenchymal stem cells (MSCs) for cell therapy and regenerative medicine has received widespread attention over the past few years, but their application can be complicated by factors such as reduction in proliferation potential, the senescent tendency of the MSCs upon expansion and their age-dependent decline in number and function. It was shown that all the mentioned features were accompanied by a reduction in telomerase activity and telomere shortening. Furthermore, the role of epigenetic changes in aging, especially changes in promoter methylation, was reported...
2017: PloS One
https://www.readbyqxmd.com/read/29145499/clinical-tool-for-disease-phenotyping-in-granulomatous-lung-disease
#9
Lori J Silveira, Matthew Strand, Michael V Van Dyke, Margaret M Mroz, Anna V Faino, Dana M Dabelea, Lisa A Maier, Tasha E Fingerlin
BACKGROUND: Exposure to beryllium may lead to granuloma formation and fibrosis in those who develop chronic beryllium disease (CBD). Although disease presentation varies from mild to severe, little is known about CBD phenotypes. This study characterized CBD disease phenotypes using longitudinal measures of lung function. METHODS: Using a case-only study of 207 CBD subjects, subject-specific trajectories over time were estimated from longitudinal pulmonary function and exercise-tolerance tests...
2017: PloS One
https://www.readbyqxmd.com/read/29145490/rnai-screen-reveals-a-role-of-sphk2-in-dengue-virus-mediated-apoptosis-in-hepatic-cell-lines
#10
Atthapan Morchang, Regina Ching Hua Lee, Pa-Thai Yenchitsomanus, Gopinathan Pillai Sreekanth, Sansanee Noisakran, Justin Jang Hann Chu, Thawornchai Limjindaporn
Hepatic dysfunction is a feature of dengue virus (DENV) infection. Hepatic biopsy specimens obtained from fatal cases of DENV infection show apoptosis, which relates to the pathogenesis of DENV infection. However, how DENV induced liver injury is not fully understood. In this study, we aim to identify the factors that influence cell death by employing an apoptosis-related siRNA library screening. Our results show the effect of 558 gene silencing on caspase 3-mediated apoptosis in DENV-infected Huh7 cells. The majority of genes that contributed to apoptosis were the apoptosis-related kinase enzymes...
2017: PloS One
https://www.readbyqxmd.com/read/29145459/the-construction-of-ventilation-turrets-in-atta-vollenweideri-leaf-cutting-ants-carbon-dioxide-levels-in-the-nest-tunnels-but-not-airflow-or-air-humidity-influence-turret-structure
#11
Florian Halboth, Flavio Roces
Nest ventilation in the leaf-cutting ant Atta vollenweideri is driven via a wind-induced mechanism. On their nests, workers construct small turrets that are expected to facilitate nest ventilation. We hypothesized that the construction and structural features of the turrets would depend on the colony's current demands for ventilation and thus might be influenced by the prevailing environmental conditions inside the nest. Therefore, we tested whether climate-related parameters, namely airflow, air humidity and CO2 levels in the outflowing nest air influenced turret construction in Atta vollenweideri...
2017: PloS One
https://www.readbyqxmd.com/read/29145421/radiographic-prediction-of-meningioma-grade-by-semantic-and-radiomic-features
#12
Thibaud P Coroller, Wenya Linda Bi, Elizabeth Huynh, Malak Abedalthagafi, Ayal A Aizer, Noah F Greenwald, Chintan Parmar, Vivek Narayan, Winona W Wu, Samuel Miranda de Moura, Saksham Gupta, Rameen Beroukhim, Patrick Y Wen, Ossama Al-Mefty, Ian F Dunn, Sandro Santagata, Brian M Alexander, Raymond Y Huang, Hugo J W L Aerts
OBJECTIVES: The clinical management of meningioma is guided by tumor grade and biological behavior. Currently, the assessment of tumor grade follows surgical resection and histopathologic review. Reliable techniques for pre-operative determination of tumor grade may enhance clinical decision-making. METHODS: A total of 175 meningioma patients (103 low-grade and 72 high-grade) with pre-operative contrast-enhanced T1-MRI were included. Fifteen radiomic (quantitative) and 10 semantic (qualitative) features were applied to quantify the imaging phenotype...
2017: PloS One
https://www.readbyqxmd.com/read/29145333/risk-factors-and-a-simple-model-for-predicting-bile-leakage-after-radical-hepatectomy-in-patients-with-hepatic-alveolar-echinococcosis
#13
Xianwei Yang, Yiwen Qiu, Wentao Wang, Xi Feng, Shu Shen, Bo Li, Tianfu Wen, Jiayin Yang, Mingqing Xu, Zheyu Chen, Lunan Yan
Postoperative bile leakage (BL) is a major complication of hepatic alveolar echinococcosis (HAE). The purpose of this study was to identify the risk factors for BL and to establish a simple scoring system for predicting BL.A total of 152 patients with HAE were included in the study between May 2004 and December 2016. The patient's baseline data, laboratory blood tests, imaging features, and surgical management were collected. Univariate and multivariate analyses were used to screen for factors to predict BL...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145332/primary-malignant-melanoma-of-the-lung-a-case-report-and-literature-review
#14
Juan Peng, Fengfeng Han, Tianyun Yang, Jinyuan Sun, Wenbin Guan, Xuejun Guo
RATIONALE: Primary malignant melanoma of the lung (PMML) is an extremely rare neoplasm with a dismal prognosis. The diagnosis of PMML is very difficult and is based on several clinical, radiological, and histopathological criteria. PATIENT CONCERNS: A 61-year-old women was admitted with a 2-month history of a productive cough and chest pain provoked by breathing and coughing. Computed tomography (CT) scans of the chest showed a large, solid tumor in the right middle lobe of the lung...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145318/an-unusual-cause-of-fever-of-unknown-origin-with-enlarged-lymph-nodes-relapsing-polychondritis-a-case-report
#15
Wei Liu, Hongli Jiang, Han Jing, Bing Mao
INTRODUCTION: Fever of unknown origin (FUO) is a common initial presentation leading to a diagnostic challenge. PATIENT CONCERNS: A 3-month history of moderate-to-high fever was reported in an otherwise healthy 54-year-old man. Enhanced computed tomography (CT) scans of his chest showed a remarkable progressive enlargement of bilateral cervical, supraclavicular, hilar, and mediastinal lymph nodes within 2 weeks. Bronchofibroscopy manifested obvious luminal stenosis with swelling, thick pale mucosa, and disappearing of structures of trachea cricoid cartilage, followed by a 18F-fluorodeoxyglucose positron-emission tomography-computed tomography (18F-FDG PET/CT) with intense symmetric FDG uptake in larynx, tracheobronchial tree, and hilar, mediastinal, and axillary lymph nodes being demonstrated...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145305/prognostic-significance-of-metabolic-enzyme-pyruvate-kinase-m2-in-breast-cancer-a-meta-analysis
#16
Yiming Yang, Ke Wu, Yulin Liu, Liang Shi, Kaixiong Tao, Guobin Wang
BACKGROUNDS: Numerous studies have reported that aberrant pyruvate kinase M2 isoform (PKM2) expressed in cancer, indicating that PKM2 plays a critical role in tumor initiation and progression. Nevertheless, its prognostic value in breast cancer tumor is yet contentious. Therefore, we performed this meta-analysis to evaluate the prognostic significance of PKM2 in breast cancer. METHODS: Eligible relevant literatures were retrieved by searching PubMed, the Cochrane Library, Embase through December 2016...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145304/partially-cystic-thyroid-nodules-in-ultrasound-guided-fine-needle-aspiration-prevalence-of-thyroid-carcinoma-and-ultrasound-features
#17
Wenbo Li, Qingli Zhu, Yuxin Jiang, Qing Zhang, Zhilan Meng, Jian Sun, Jianchu Li, Qing Dai
Partially cystic thyroid nodules (PCTNs) are common on ultrasound (US). However, there are insufficient data on the prevalence of thyroid carcinoma among such nodules. The purpose of this study was thus to evaluate the prevalence and differentiation of partially cystic thyroid cancers in US-guided fine needle aspiration (FNA).A total of 1342 consecutive patients with 1360 thyroid nodules underwent prospective US diagnosis and FNA biopsy. In total, 281 nodules (20.7%) were partially cystic lesions. The nodules were prospectively analyzed based on US features (ie, solid portion positions, shapes, margins, and microcalcifications) and US diagnosis (benign, suspicious, or malignant)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145292/recurrent-spinal-primitive-neuroectodermal-tumor-with-brain-and-bone-metastases-a-case-report
#18
Frank Chen, Shyh-Shin Chiou, Sheng-Fung Lin, Ann-Shung Lieu, Yi-Ting Chen, Chih-Jen Huang
RATIONALE: Primary spinal primitive neuroectodermal tumor (PNET) is relatively rare in all age groups, and the prognosis in most cases of spinal PNETs appears to be poor, with a median patient survival of 1 to 2 years. We present a case with recurrent spinal PNET with brain and bone metastases that was successfully treated by multimodality treatment. PATIENT CONCERNS: A 14-year-old teenage girl had suffered from progressive left upper back pain with bilateral lower legs weakness and numbness for 1 year...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145285/degeneration-of-paramedian-nuclei-in-the-thalamus-induces-holmes-tremor-in-a-case-of-artery-of-percheron-infarction
#19
Tz-Shiang Wei, Chun-Sheng Hsu, Yu-Chun Lee, Shin-Tsu Chang
RATIONALE: Holmes' tremor is an uncommon neurologic disorder following brain insults, and its pathogenesis is undefined. The interruption of the dento-rubro-thalamic tract and secondary deterioration of the nigrostriatal pathway are both required to initiate Holmes' tremor. We used nuclear medicine imaging tools to analyze a patient with concurrent infarction in different zones of each side of the thalamus. Finding whether the paramedian nuclear groups of the thalamus were injured was a decisive element for developing Holmes' tremor...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145277/tricho-hepato-enteric-syndrome-with-novel-skiv2l-gene-mutations-a-case-report
#20
Eitaro Hiejima, Takahiro Yasumi, Hiroshi Nakase, Minoru Matsuura, Yusuke Honzawa, Hirokazu Higuchi, Ikuo Okafuji, Tohru Yorifuji, Takayuki Tanaka, Kazushi Izawa, Tomoki Kawai, Ryuta Nishikomori, Toshio Heike
RATIONALE: Tricho-hepato-enteric syndrome (THES) is a rare disorder caused by mutations in the TTC37 or SKIV2L genes and characterized by chronic diarrhea, liver disease, hair abnormalities, and high mortality in early childhood due to severe infection or liver cirrhosis. PATIENT CONCERNS: The patient is the second child of three siblings born to non-consanguineous healthy Japanese parents. She had intrauterine growth retardation and was delivered at 33 weeks of gestation due to placental abruption...
November 2017: Medicine (Baltimore)
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