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https://www.readbyqxmd.com/read/28817229/performance-equivalency-between-computer-based-and-traditional-pen-and-paper-assessment-a-case-study-in-clinical-anatomy
#1
Bruno Guimarães, José Ribeiro, Bernardo Cruz, André Ferreira, Hélio Alves, Ricardo Cruz-Correia, Maria Dulce Madeira, Maria Amélia Ferreira
The time, material, and staff-consuming nature of anatomy's traditional pen-and-paper assessment system, the increase in the number of students enrolling in medical schools and the ever-escalating workload of academic staff have made the use of computer-based assessment (CBA) an attractive proposition. To understand the impact of such shift in the assessment method, an experimental study evaluating its effect on students' performance was designed. Additionally, students' opinions toward CBA were gathered. Second-year medical students attending a Clinical Anatomy course were randomized by clusters in two groups...
August 17, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28815412/study-of-the-removal-mechanism-of-aquatic-emergent-pollutants-by-new-bio-based-chars
#2
Maria Manuel Serrano Bernardo, Catarina Alexandra Catanas Madeira, Nuno Carlos Lapa Dos Santos Nunes, Diogo André Costa Messias Dias, Delfina Maria Barbosa Godinho, Maria Filomena de Jesus Pinto, Inês Alexandra Morgado do Nascimento Matos, Ana Paula Batista Carvalho, Isabel Maria de Figueiredo Ligeiro Fonseca
This work is dedicated to study the potential application of char byproducts obtained in the gasification of rice husk (RG char) and rice husk blended with corn cob (RCG char) as removal agents of two emergent aquatic contaminants: tetracycline and caffeine. The chars presented high ash contents (59.5-81.5%), being their mineral content mainly composed of silicon (as silica) and potassium. The samples presented a strong basic character, which was related to its higher mineral oxides content. RCG char presented better textural properties with a higher apparent surface area (144 m(2) g(-1)) and higher micropore content (V micro = 0...
August 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28806395/rad6-promotes-dna-repair-and-stem-cell-signaling-in-ovarian-cancer-and-is-a-promising-therapeutic-target-to-prevent-and-treat-acquired-chemoresistance
#3
R R Somasagara, S M Spencer, K Tripathi, D W Clark, C Mani, L Madeira da Silva, J Scalici, H Kothayer, A D Westwell, R P Rocconi, K Palle
Ovarian cancer (OC) is the most deadly gynecological cancer and unlike most other neoplasms, survival rates for OC have not significantly improved in recent decades. We show that RAD6, an ubiquitin-conjugating enzyme, is significantly overexpressed in ovarian tumors and its expression increases in response to carboplatin chemotherapy. RAD6 expression correlated strongly with acquired chemoresistance and malignant behavior of OC cells, expression of stem cell genes and poor prognosis of OC patients, suggesting an important role for RAD6 in ovarian tumor progression...
August 14, 2017: Oncogene
https://www.readbyqxmd.com/read/28798727/methionine-residues-in-exoproteins-and-their-recycling-by-methionine-sulfoxide-reductase-ab-serve-as-an-antioxidant-strategy-in-bacillus-cereus
#4
Jean-Paul Madeira, Béatrice M Alpha-Bazin, Jean Armengaud, Catherine Duport
During aerobic respiratory growth, Bacillus cereus is exposed to continuously reactive oxidant, produced by partially reduced forms of molecular oxygen, known as reactive oxygen species (ROS). The sulfur-containing amino acid, methionine (Met), is particularly susceptible to ROS. The major oxidation products, methionine sulfoxides, can be readily repaired by methionine sulfoxide reductases, which reduce methionine sulfoxides [Met(O)] back to methionine. Here, we show that methionine sulfoxide reductase AB (MsrAB) regulates the Met(O) content of both the cellular proteome and exoproteome of B...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28796120/synthetic-cannabis-analogues-and-suicidal-behavior-case-report
#5
Pedro Miguel Dos Santos Oliveira, Ana Sofia Félix Morais, Nuno Gonçalo Gomes Fernandes Madeira
INTRODUCTION: Despite growing legal control, a wide range of synthetic cannabis analogues is currently used for recreational purposes, notwithstanding their well adverse outcomes, which appear to be more frequent and more serious than those associated with cannabis use. We present the case report of a patient with paranoid schizophrenia, who attempted suicide by serious bodily harm after a single use of "Shiva Ultra Strong," a compound of several synthetic cannabis analogues. CASE SUMMARY: A 32-year-old male patient with paranoid schizophrenia was brought to the emergency department presenting with a severe self-inflicted wound to the neck which lacerated the right jugular vein and ipsilateral airway, and narrowly missed the carotid bifurcation...
August 8, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28793868/clinical-and-laboratory-profiles-of-patients-with-early-spontaneous-healing-in-cutaneous-localized-leishmaniasis-a-historical-cohort-study
#6
Carla Oliveira-Ribeiro, Maria Inês Fernandes Pimentel, Raquel de Vasconcellos Carvalhaes Oliveira, Aline Fagundes, Maria de Fatima Madeira, Cintia Xavier Mello, Eliame Mouta-Confort, Claudia Maria Valete-Rosalino, Erica de Camargo Ferreira Vasconcellos, Marcelo Rosandiski Lyra, Leonardo Pereira Quintella, Liliane de Fatima Antonio, Armando Schubach, Fatima Conceição-Silva
BACKGROUND: Skin ulcers in American cutaneous leishmaniasis (ACL) may heal spontaneously after months/years. However, few cases may present quick heal even during diagnosis procedure (early spontaneous healing- ESH). The main objective of this study was to compare ESH patients with cases requiring specific treatment [non-ESH (NESH)]. METHODS: A historical cohort study of ACL patients (n = 445) were divided into 2 groups: ESH - spontaneously healed patients (n = 13; 2...
August 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28768550/abuse-and-disrespect-in-childbirth-process-and-abortion-situation-in-latin-america-and-the-caribbean-systematic-review-protocol
#7
Sofia Madeira, Vicky Pileggi, João Paulo Souza
BACKGROUND: Studies show that a large number of women around the world have experienced situations of abuse, disrespect, abuse, and neglect during childbirth and/or abortion. This violence is a serious violation of the rights of women, especially because it is a period in which the woman is more physiologically, socially, and psychologically vulnerable. Although this type of violence is known, there is still no international consensus on the definition of such violence and its prevalence is not known...
August 3, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28766137/inhaled-glucocorticoids-are-associated-with-vertebral-fractures-in-copd-patients
#8
Pedro Assed Gonçalves, Rafael Dos Santos Neves, Leonardo Vieira Neto, Miguel Madeira, Fernando Silva Guimarães, Laura Maria Carvalho Mendonça, Agnaldo Jose Lopes, Maria Lucia Fleiuss Farias
Chronic obstructive pulmonary disease (COPD) is an independent risk factor for osteoporosis. Oral glucocorticoids are deleterious to bone; however, the impact of inhaled glucocorticoids (ICS) remains unclear. Our objective was to determine whether ICS contribute to osteoporosis and fragility fractures. Sixty-one COPD patients, 35 current users of ICS and 26 who had never received glucocorticoids, were evaluated for bone mineral density (BMD) and body composition and underwent vertebral fracture assessment (VFA)...
August 1, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28745923/prevalence-prevention-and-severity-of-prescribing-errors-in-different-years-of-residency-training-at-an-oncology-ward
#9
Amanda Canato Ferracini, Cinthia Madeira de Souza, Aline Teotonio Rodrigues, Patricia Moriel, Sophie F M Derchain, Priscila Gava Mazzola
No abstract text is available yet for this article.
July 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/28744927/hyphessobrycon-platyodus-teleostei-characiformes-a-new-species-from-the-rio-madeira-basin-brazil-with-comments-on-how-multicuspid-teeth-relate-to-feeding-habits-in-characidae
#10
W M Ohara, V P Abrahão, V C Espíndola
A new species of Hyphessobrycon is described from the Rio Juma, a tributary of the lower Rio Aripuanã-Rio Madeira basin, Amazonas, Brazil. Hyphessobrycon platyodus can be distinguished from its congeners by the: presence of an elongated dorsal fin in adult males, 25-28 branched anal-fin rays and absence of dark blotches from the dorsal fin and caudal peduncle. The presence of multicuspid teeth in species of Characidae and its relation with feeding habits are briefly commented on.
July 26, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28742096/insecticide-resistance-is-mediated-by-multiple-mechanisms-in-recently-introduced-aedes-aegypti-from-madeira-island-portugal
#11
Gonçalo Seixas, Linda Grigoraki, David Weetman, José Luís Vicente, Ana Clara Silva, João Pinto, John Vontas, Carla Alexandra Sousa
BACKGROUND: Aedes aegypti is a major mosquito vector of arboviruses, including dengue, chikungunya and Zika. In 2005, Ae. aegypti was identified for the first time in Madeira Island. Despite an initial insecticide-based vector control program, the species expanded throughout the Southern coast of the island, suggesting the presence of insecticide resistance. Here, we characterized the insecticide resistance status and the underlying mechanisms of two populations of Ae. aegypti from Madeira Island, Funchal and Paúl do Mar...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28735562/diagnostic-and-therapeutic-knowledge-and-practices-in-the-management-of-congenital-syphilis-by-pediatricians-in-public-maternity-hospitals-in-brazil
#12
Raquel Rodrigues Dos Santos, Roberta Pereira Niquini, Francisco Inácio Bastos, Rosa Maria Soares Madeira Domingues
The study aimed to assess conformity with Brazil's standard protocol for diagnostic and therapeutic practices in the management of congenital syphilis by pediatricians in public maternity hospitals. A cross-sectional study was conducted in 2015 with 41 pediatricians working in all the public maternity hospitals in Teresina, the capital of Piauí State, Northeast Brazil, through self-completed questionnaires. The study assessed the conformity of knowledge and practices according to the Brazilian Ministry of Health protocols...
January 1, 2017: International Journal of Health Services: Planning, Administration, Evaluation
https://www.readbyqxmd.com/read/28734020/molecular-analysis-of-brazilian-patients-with-combined-pituitary-hormone-deficiency-and-orthotopic-posterior-pituitary-lobe-reveals-eight-different-prop1-alterations-with-three-novel-mutations
#13
Joao L O Madeira, Mirian Y Nishi, Marilena Nakaguma, Anna F Benedetti, Isabela Peixoto Biscotto, Thamiris Fernandes, Thiago Pequeno, Thalita Figueiredo, Marcela M Franca, Fernanda A Correa, Aline P Otto, Milena Abrão, Mirta B Miras, Silvana Santos, Alexander A L Jorge, Everlayny F Costalonga, Berenice B Mendonca, Ivo J P Arnhold, Luciani R Carvalho
BACKGROUND: Mutations in PROP1, HESX1, and LHX3 are associated with combined pituitary hormone deficiency (CPHD) and orthotopic posterior pituitary lobe (OPP). OBJECTIVE: To identify mutations in PROP1, HESX1, and LHX3 in a large cohort of patients with CPHD and OPP (35 Brazilian, 2 Argentinian). DESIGN AND METHODS: We studied 23 index patients with CPHD and OPP (6 familial and 17 sporadic) as well as 14 relatives. PROP1 was sequenced by the Sanger method in all except one sporadic case studied using a candidate gene panel...
July 22, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28727943/the-genetic-background-of-metabolic-trait-clusters-in-children-and-adolescents
#14
Karri Silventoinen, Élvio Gouveia, Aline Jelenkovic, José Maia, António M Antunes, Miguel A A Pinheiro de Carvalho, António M Brehm, Martine Thomis, Johan Lefevre, Jaakko Kaprio, Duarte Freitas
BACKGROUND: It is well known that metabolic risk factors of cardiovascular diseases are correlated, but the background of this clustering in children is more poorly known than in adults. Thus, we studied the contribution of genetic and environmental factors to the clustering of metabolic traits in childhood and adolescence. DATA AND METHODS: Nine metabolic traits were measured in 214 complete twin pairs aged 3-18 years in the Autonomous Region of Madeira, Portugal, in 2007 and 2008...
July 20, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28724366/predicting-progression-of-mild-cognitive-impairment-to-dementia-using-neuropsychological-data-a-supervised-learning-approach-using-time-windows
#15
Telma Pereira, Luís Lemos, Sandra Cardoso, Dina Silva, Ana Rodrigues, Isabel Santana, Alexandre de Mendonça, Manuela Guerreiro, Sara C Madeira
BACKGROUND: Predicting progression from a stage of Mild Cognitive Impairment to dementia is a major pursuit in current research. It is broadly accepted that cognition declines with a continuum between MCI and dementia. As such, cohorts of MCI patients are usually heterogeneous, containing patients at different stages of the neurodegenerative process. This hampers the prognostic task. Nevertheless, when learning prognostic models, most studies use the entire cohort of MCI patients regardless of their disease stages...
July 19, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28717771/human-papillomavirus-induced-cancer-late-relapse-in-a-patient-treated-with-tumor-necrosis-factor-alpha-inhibitor
#16
Gabriel Madeira Werberich, Tatiana Strava, Carolina Vizioli, Gustavo Dos Santos Fernandes
No abstract text is available yet for this article.
June 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28703291/the-recent-colonization-of-south-brazil-by-the-azores-chromis-chromis-limbata
#17
A B Anderson, E M Salas, L A Rocha, S R Floeter
The damselfish Chromis limbata is native to the Macaronesian Archipelagos (Azores, Madeira and Canaries) and the western coast of Africa between Senegal and Angola. During the austral summers of 2008 and 2009 the species was recorded for the first time in the south-western Atlantic Ocean around Campeche and Xavier Islands, in Florianópolis, Santa Catarina State, Brazil. Here, the progression of C. limbata in southern Brazilian waters is described using visual counts and genetic surveys and changes in the density of the native congener Chromis multilineata were also investigated...
July 13, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28683145/geographical-distribution-of-culicoides-diptera-ceratopogonidae-in-mainland-portugal-presence-absence-modelling-of-vector-and-potential-vector-species
#18
David W Ramilo, Telmo Nunes, Sara Madeira, Fernando Boinas, Isabel Pereira da Fonseca
Vector-borne diseases are not only accounted responsible for their burden on human health-care systems, but also known to cause economic constraints to livestock and animal production. Animals are affected directly by the transmitted pathogens and indirectly when animal movement is restricted. Distribution of such diseases depends on climatic and social factors, namely, environmental changes, globalization, trade and unplanned urbanization. Culicoides biting midges are responsible for the transmission of several pathogenic agents with relevant economic impact...
2017: PloS One
https://www.readbyqxmd.com/read/28672724/anticancer-drugs-in-portuguese-surface-waters-estimation-of-concentrations-and-identification-of-potentially-priority-drugs
#19
Mónica S F Santos, Helena Franquet-Griell, Silvia Lacorte, Luis M Madeira, Arminda Alves
Anticancer drugs, used in chemotherapy, have emerged as new water contaminants due to their increasing consumption trends and poor elimination efficiency in conventional water treatment processes. As a result, anticancer drugs have been reported in surface and even drinking waters, posing the environment and human health at risk. However, the occurrence and distribution of anticancer drugs depend on the area studied and the hydrological dynamics, which determine the risk towards the environment. The main objective of the present study was to evaluate the risk of anticancer drugs in Portugal...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28671901/effectiveness-and-safety-of-an-extended-icu-visitation-model-for-delirium-prevention-a-before-and-after-study
#20
Regis Goulart Rosa, Tulio Frederico Tonietto, Daiana Barbosa da Silva, Franciele Aparecida Gutierres, Aline Maria Ascoli, Laura Cordeiro Madeira, William Rutzen, Maicon Falavigna, Caroline Cabral Robinson, Jorge Ibrain Salluh, Alexandre Biasi Cavalcanti, Luciano Cesar Azevedo, Rafael Viegas Cremonese, Tarissa Ribeiro Haack, Cláudia Severgnini Eugênio, Aline Dornelles, Marina Bessel, José Mario Meira Teles, Yoanna Skrobik, Cassiano Teixeira
OBJECTIVES: To evaluate the effect of an extended visitation model compared with a restricted visitation model on the occurrence of delirium among ICU patients. DESIGN: Prospective single-center before and after study. SETTING: Thirty-one-bed medical-surgical ICU. PATIENTS: All patients greater than or equal to 18 years old with expected length of stay greater than or equal to 24 hours consecutively admitted to the ICU from May 2015 to November 2015...
June 30, 2017: Critical Care Medicine
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