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F N Morgado, L M V de Carvalho, J Leite-Silva, A J Seba, M I F Pimentel, A Fagundes, M F Madeira, M R Lyra, M M Oliveira, A O Schubach, F Conceição-Silva
The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis...
February 13, 2018: Scientific Reports
Rosa Maria Soares Madeira Domingues, Valeria Saraceni, Maria do Carmo Leal
AIMS: to estimate the mother to child transmission (MTCT) of HIV among infected pregnant women identified in the "Birth in Brazil" study and to evaluate care practices provided in order to identify missed opportunities at preventing the MTCT of HIV infection in the country. METHODS: Descriptive study using data obtained from the consultation of different databases: the "Birth in Brazil" study database and the Brazilian National Information Systems (NIS) databases...
2018: PloS One
Maria Giese, Julia Gestrich, Azar Massah, Jonas Peterle, HongYing Wei, Monika Stengl
In the Madeira cockroach pigment-dispersing factor-immunoreactive (PDF-ir) neurons innervating the circadian clock, the accessory medulla (AME) in the brain's optic lobes, control circadian behavior. Circadian activity rhythms are entrained to daily light-dark cycles only by compound eye photoreceptors terminating in the lamina and medulla. Still, it is unknown which neurons connect the photoreceptors to the clock to allow for light-entrainment. Here, we characterized by multiple-label immunocytochemistry the serotonin (5-HT)-ir anterior fiber fan and GABA-ir pathways connecting the AME- and optic lobe neuropils...
February 11, 2018: European Journal of Neuroscience
Katy R Nicastro, Roberto Lo Savio, Christopher D McQuaid, Pedro Madeira, Ugo Valbusa, Fábia Azevedo, Maria Casero, Carla Lourenço, Gerardo I Zardi
Excessive use of plastics in daily life and the inappropriate disposal of plastic products are severely affecting wildlife species in both coastal and aquatic environments. Birds are top-predators, exposed to all threats affecting their environments, making them ideal sentinel organisms for monitoring ecosystems change. We set a baseline assessment of the prevalence of marine plastic litter affecting multi-species populations of aquatic birds in southern Portugal. By examining 160 stomach contents from 8 species of aquatic birds, we show that 22...
January 2018: Marine Pollution Bulletin
Sérgio P Ávila, Ricardo Cordeiro, Patrícia Madeira, Luís Silva, António Medeiros, Ana C Rebelo, Carlos Melo, Ana I Neto, Ricardo Haroun, António Monteiro, Kenneth Rijsdijk, Markes E Johnson
Past climate changes provide important clues for advancement of studies on current global change biology. We have tested large-scale biogeographic patterns through four marine groups from twelve Atlantic Ocean archipelagos and searched for patterns between species richness/endemism and littoral area, age, isolation, latitude and mean annual sea-surface temperatures. Species richness is strongly correlated with littoral area. Two reinforcing effects take place during glacial episodes: i) species richness is expected to decrease (in comparison with interglacial periods) due to the local disappearance of sandy/muddy-associated species; ii) because littoral area is minimal during glacial episodes, area per se induces a decrease on species richness (by extirpation/extinction of marine species) as well as affecting speciation rates...
January 2018: Marine Pollution Bulletin
Ana C Rodrigues-Neves, Inês D Aires, Joana Vindeirinho, Raquel Boia, Maria H Madeira, Francisco Q Gonçalves, Rodrigo A Cunha, Paulo F Santos, António F Ambrósio, Ana R Santiago
Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the pathophysiology of this disease. Although global changes of the purinergic system have been reported in experimental and human glaucoma, it is not known if this is due to alterations of the purinergic system of microglial cells, the resident immune cells of the central nervous system...
2018: Frontiers in Pharmacology
Willy De Mattia, Marco T Neiber, Klaus Groh
The genus-group Hystricella R. T. Lowe, 1855 is revised on the basis of conchological, anatomical and genetic characteristics. A new genus Wollastoniagen. n., two recent species, W. jessicaesp. n. and W. klausgrohisp. n., and one recent subspecies, W. jessicae monticolassp. n. are described as new to science, as well as five fossil taxa, H. microcarinatasp. n., W. beckmannisp. n., W. falknerorumsp. n., W. ripkenisp. n., and W. inexpectatasp. n. For Helix vermetiformis R. T. Lowe, 1855, H. leacockiana Wollaston, 1878, H...
2018: ZooKeys
Enrico Heffler, Lorena Nascimento Girardi Madeira, Matteo Ferrando, Francesca Puggioni, Francesca Racca, Luca Malvezzi, Gianni Passalacqua, Giorgio Walter Canonica
Asthma is a common inflammatory airway disease for which the most commonly used controller medications are inhaled corticosteroids (ICS). Asthma control is difficult to achieve in individuals with severe asthma, which comprise 5-10% of individuals with asthma, even with high doses of ICS and other anti-inflammatory drugs. In this clinical context, the adverse effects of ICS (including hypothalamic-pituitary-adrenal axis suppression, reduction in growth velocity, osteoporosis, diabetes, and respiratory infections) become more probable and impacting on the quality of life of severe asthmatics...
February 2, 2018: Journal of Allergy and Clinical Immunology in Practice
Margarida Hermida, Bárbara Cavaleiro, Lídia Gouveia, Aurélia Saraiva
Skipjack tuna, Katsuwonus pelamis, is a tropical species of economic importance for fisheries around the world. It occurs seasonally in subtropical waters around Madeira archipelago, in the warmer months. In this study, a parasitological analysis was carried out on a sample of 30 skipjack caught near Madeira Island. A total of 24 parasite taxa were found in this sample. The skipjack parasite community detected was characterized by a wide diversity of parasites, with a predominance of adult didymozoid trematodes, and high prevalences of Tentacularia coryphaenae cestode larvae and Anisakis sp...
February 3, 2018: Parasitology Research
M H Madeira, K Rashid, A F Ambrósio, A R Santiago, T Langmann
Age-related macular degeneration (AMD) is characterized by pathological changes in the retinal pigment epithelium (RPE) and loss of photoreceptors. Growing evidence has demonstrated that reactive microglial cells trigger RPE dysfunction and loss of photoreceptors, and inflammasome pathways and complement activation contribute to AMD pathogenesis. We and others have previously shown that adenosine A2A receptor (A2AR) blockade prevents microglia-mediated neuroinflammatory processes and mediates protection to the retina...
February 2, 2018: Scientific Reports
Sergio Santorelli, William E Magnusson, Claudia P Deus
At broad scales in the Amazon, it is often hypothesized that species distributions are limited by geographical barriers, such as large rivers (river-barrier hypothesis). This hypothesis has been used to explain the spatial-distribution limits of species and to indicate endemism areas for several phylogenetic lineages. We tested the ability of the river-barrier hypothesis to explain patterns of species diversity and spatial-distribution limits for 1952 easily-detected species in 14 taxonomic groups that occur around the Madeira River, and our results indicate that the hypothesis that the Madeira River is the border between endemism areas and explains much of the diversity found in the region is inappropriate for >99% of species...
February 2, 2018: Scientific Reports
Peter V Troshin, James B Procter, Alexander Sherstnev, Daniel L Barton, Fábio Madeira, Geoffrey J Barton
Summary: JABAWS 2.2 is a computational framework that simplifies the deployment of web services for Bioinformatics. In addition to the five multiple sequence alignment (MSA) algorithms in JABAWS 1.0, JABAWS 2.2 includes three additional MSA programs (Clustal Omega, MSAprobs, GLprobs), four protein disorder prediction methods (DisEMBL, IUPred, Ronn, GlobPlot), 18 measures of protein conservation as implemented in AACon, and RNA secondary structure prediction by the RNAalifold program. JABAWS 2...
January 30, 2018: Bioinformatics
Christian Mohn, Anneke Denda, Svenja Christiansen, Manfred Kaufmann, Florian Peine, Barbara Springer, Robert Turnewitsch, Bernd Christiansen
Seamounts are amongst the most common physiographic structures of the deep-ocean landscape, but remoteness and geographic complexity have limited the systematic collection of integrated and multidisciplinary data in the past. Consequently, important aspects of seamount ecology and dynamics remain poorly studied. We present a data collection of ocean currents and raw acoustic backscatter from shipboard Acoustic Doppler Current Profiler (ADCP) measurements during six cruises between 2004 and 2015 in the tropical and subtropical Northeast Atlantic to narrow this gap...
April 2018: Data in Brief
Margarida Lima Carvalho, Guilherme José da Costa Silva, Silvana Melo, Fernando Yuldi Ashikaga, Cristiane Kioko Shimabukuro-Dias, Priscilla Cardim Scacchetti, Renato Devidé, Fausto Foresti, Claudio Oliveira
The combination of cytogenetic and molecular data with those traditionally obtained in areas like systematics and taxonomy created interesting perspectives for the analysis of natural populations under different aspects. In this context, this study aimed to evaluate the genetic differentiation among populations of the genus Hemiodontichthys Bleeker, 1862, through combined genetic techniques and included the analysis of populations sampled in the Araguaia River, Guamá River, Madeira River and two populations from the Purus River...
January 31, 2018: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
Gregory Thom, Fabio R Amaral, Michael J Hickerson, Alexandre Aleixo, Lucas E Araujo-Silva, Camila C Ribas, Erik Choueri, Cristina Y Miyaki
Before populations become independent evolutionary lineages, the effects of micro evolutionary processes tend to generate complex scenarios of diversification that may affect phylogenetic reconstruction. Not accounting for gene flow in species tree estimates can directly impact topology, effective population sizes and branch lengths and the resulting estimation errors are still poorly understood in wild populations. In this study we used an integrative approach, including sequence capture of Ultra Conserved Elements (UCEs), mtDNA Sanger sequencing and morphological data to investigate species limits and phylogenetic relationships in face of gene flow in an Amazonian endemic species (Myrmoborus lugubris: Aves)...
January 29, 2018: Systematic Biology
Diogo de Almeida Fernandes, Natália António, Marta Madeira, Pedro Sousa, Miguel Ventura, João Cristóvão, José Nascimento, Luís Elvas, Lino Gonçalves, Guilherme Mariano Pego
PURPOSE: Brugada syndrome is a hereditary disease linked with an increased risk of sudden death that may require an implantable cardioverter-defibrillator (ICD) in order to halt the arrhythmic events. The aim of this study was to identify possible triggers for appropriate ICD therapies in patients with Brugada syndrome, focusing on their past and current therapeutic profiles. METHODS: Thirty patients with high-risk Brugada syndrome, with ICD implanted at the Coimbra Hospital and University Center, were enrolled...
January 25, 2018: Cardiovascular Drugs and Therapy
Nuno Cardim, Dulce Brito, Luís Rocha Lopes, António Freitas, Carla Araújo, Adriana Belo, Lino Gonçalves, Jorge Mimoso, Iacopo Olivotto, Perry Elliott, Hugo Madeira
INTRODUCTION: We report the results of the Portuguese Registry of Hypertrophic Cardiomyopathy, an initiative that reflects the current spectrum of cardiology centers throughout the territory of Portugal. METHODS: A direct invitation to participate was sent to cardiology departments. Baseline and outcome data were collected. RESULTS: A total of 29 centers participated and 1042 patients were recruited. Four centers recruited 49% of the patients, of whom 59% were male, and mean age at diagnosis was 53±16 years...
January 19, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Miguel Vieira, José V E Bernardi, José G Dórea, Bruno C P Rocha, Romulo Ribeiro, Luis F Zara
Waters from the Amazon Basin have distinct physicochemical characteristics that can be optically classified as "black", "clear" and "white". We studied the distribution of total-Hg (THg) and methyl-Hg (MeHg) in these waters and respective suspended solids, sediment, phytoplankton, zooplankton, and benthic macroinvertebrates (BM) in the Madeira River Basin. Compared with the other types of water, the more acidic "black" kind had the highest THg and MeHg concentrations. The trend (black > clear > white) occurred for the concentrations of THg and MeHg in sediments and in the biotic compartment (plankton, macroinvertebrates)...
January 16, 2018: Environmental Pollution
Belén Lumbierres, Filipe Madeira, Xavier Pons
Oenopia conglobata is one of the most common ladybird species in urban green areas of the Mediterranean region. We have obtained data about its prey acceptability and prey preferences. In a laboratory experiment, we investigated the acceptability of seven aphid and one psyllid species as prey for this coccinellid: the aphids Chaitophorus populeti, Aphis gossypii, Aphis craccivoraMonelliopsis caryae, Eucallipterus tiliae, Aphis nerii (on white poplar, pomegranate, false acacia, black walnut, lime, and oleander, respectively), and the psyllid Acizziajamatonica on Persian silk tree...
January 12, 2018: Insects
R C F Galvão, I B B Holanda, D P De Carvalho, R Almeida, C M M Souza, L D Lacerda, W R Bastos
Total mercury (THg) concentrations measured in two freshwater shrimp species (Macrobrachium depressimanum and Macrobrachium jelskii) showed a relationship with the location of artisanal and small-scale gold mining (ASGM) from the Madeira River Basin, Western Amazon. Between August 2009 and May 2010, 212 shrimp samples were collected in the confluence of the Madeira River with three of its tributaries (Western Amazon). THg concentration was quantified in the exoskeleton, hepatopancreas and muscle tissue of the shrimps by cold vapor atomic absorption spectrophotometry...
January 10, 2018: Environmental Monitoring and Assessment
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