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https://www.readbyqxmd.com/read/28424894/the-integrity-of-the-nucleus-of-the-lateral-olfactory-tract-is-essential-for-the-normal-functioning-of-the-olfactory-system
#1
Ricardo P Vaz, Armando Cardoso, Susana I Sá, Pedro A Pereira, M Dulce Madeira
The nucleus of the lateral olfactory tract (nLOT) is a relatively small component of the cortical pallial amygdala, with peculiar neurogenic, neurochemical and connectivity patterns. Although it has been suggested that it might be involved in non-pheromonal olfactory-guided behaviors, particularly feeding, the functional implications of the nLOT have never been investigated. In view of this fact, we have tackled this subject by performing a series of behavioral tests and by quantifying biological and biochemical parameters in sexually naïve adult male rats that were submitted to bilateral excitotoxic lesions of the nLOT...
April 19, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28419136/occurrence-of-leishmania-infantum-in-the-central-nervous-system-of-naturally-infected-dogs-parasite-load-viability-co-infections-and-histological-alterations
#2
Valéria da Costa Oliveira, Viviane Cardoso Boechat, Artur Augusto Velho Mendes Junior, Maria de Fátima Madeira, Luiz Claudio Ferreira, Fabiano Borges Figueiredo, Monique Paiva Campos, Francisco das Chagas de Carvalho Rodrigues, Raquel de Vasconcellos Carvalhaes de Oliveira, Maria Regina Reis Amendoeira, Rodrigo Caldas Menezes
Zoonotic visceral leishmaniasis is caused by the protozoan Leishmania infantum and little is known about the occurrence and pathogenesis of this parasite in the CNS. The aims of this study were to evaluate the occurrence, viability and load of L. infantum in the CNS, and to identify the neurological histological alterations associated with this protozoan and its co-infections in naturally infected dogs. Forty-eight Leishmania-seropositive dogs from which L. infantum was isolated after necropsy were examined...
2017: PloS One
https://www.readbyqxmd.com/read/28407797/association-between-length-of-residence-and-overweight-among-adult-immigrants-in-portugal-a-nationwide-cross-sectional-study
#3
Liliane Peralta da Costa, Sónia Ferreira Dias, Maria do Rosário Oliveira Martins
BACKGROUND: Despite the importance of immigrant population in Portugal few studies have analyzed the patterns of overweight/obesity in this subpopulation. The aims of this study are: (i) describe and compare the prevalence of overweight between immigrants and natives in Portugal; (ii) analyze the association between length of residence and overweight among adult immigrants in Portugal. METHODS: A cross-sectional study (2005-2006) in a representative sample of the Portuguese population from national territory, including the Autonomous Regions of Azores and Madeira...
April 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28407055/inequalities-in-obesity-in-portugal-regional-and-gender-differences
#4
Luís Alves, Silvia Stringhini, Henrique Barros, Ana Azevedo, Pedro Marques-Vidal
Obesity levels vary considerably according to geographical region and socio-economic status. We evaluated the prevalence of obesity by education and occupational position across seven Portuguese regions. Relative and absolute inequalities in obesity were also assessed. Data was drawn from the Portuguese Health Survey 2005/6 (26 674 adults, 46.6% women). Education was categorized as ≤4, 5-11 and ≥12 complete years of education. Occupational position was grouped as upper white collar, lower white collar and blue collar...
April 11, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28405644/alternative-probe-for-the-determination-of-the-hydrogen-bond-acidity-of-ionic-liquids-and-their-aqueous-solutions
#5
Pedro P Madeira, Helena Passos, Joana Gomes, João A P Coutinho, Mara G Freire
Although highly relevant to a priori select adequate solvents for a given application, the determination of the hydrogen-bond acidity or proton donor ability of aqueous solutions of ionic liquids is a difficult task due to the poor solubility of the commonly used probes in aqueous media. In this work, we demonstrate the applicability of the pyridine-N-oxide probe to determine the hydrogen-bond acidity of both neat ionic liquids and their aqueous solutions, based on (13)C NMR chemical shifts, and the suitability of these values to appraise the ability of ionic liquids to form aqueous two-phase systems...
April 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28399193/high-genetic-diversity-among-and-within-bitter-manioc-varieties-cultivated-in-different-soil-types-in-central-amazonia
#6
Alessandro Alves-Pereira, Nivaldo Peroni, Marcelo Mattos Cavallari, Maristerra R Lemes, Maria Imaculada Zucchi, Charles R Clement
Although manioc is well adapted to nutrient-poor Oxisols of Amazonia, ethnobotanical observations show that bitter manioc is also frequently cultivated in the highly fertile soils of the floodplains and Amazonian dark earths (ADE) along the middle Madeira River. Because different sets of varieties are grown in each soil type, and there are agronomic similarities between ADE and floodplain varieties, it was hypothesized that varieties grown in ADE and floodplain were more closely related to each other than either is to varieties grown in Oxisols...
April 10, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28371848/negative-effect-of-malocclusion-on-the-emotional-and-social-well-being-of-brazilian-adolescents-a-population-based-study
#7
Jéssica Madeira Bittencourt, Letícia Pereira Martins, Cristiane Baccin Bendo, Miriam Pimenta Vale, Saul Martins Paiva
Background/objectives: The aesthetic impact of malocclusion can have negative repercussions on quality of life, social interaction, interpersonal relationships, and psychological well-being. The aim of this study was to evaluate the impact of malocclusion on the quality of life of Brazilian adolescents. Methods: A representative cross-sectional study of 1612 adolescents from Belo Horizonte, Minas Gerais was conducted. The adolescents responded to the Brazilian version of the Child Perception Questionnaire (CPQ11-14-ISF:16) to assess the impact of the condition on quality of life...
March 25, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28359203/distinct-fatty-acid-composition-of-some-edible-by-products-from-bovines-fed-high-or-low-silage-diets
#8
Cristina M Alfaia, Susana P Alves, José M Pestana, Marta S Madeira, Olga Moreira, José Santos-Silva, Rui Jb Bessa, Fidel Toldrá, José Am Prates
In the present study, it was hypothesized that the incorporation of fatty acids is distinct among ruminant tissues and that it could be modulated by diet composition. To test this hypothesis, fatty acid composition, including conjugated linoleic acid isomers, of the most relevant beef by-products (brain, heart, kidney, liver, pancreas and tongue) from young bulls those fed distinct silage levels was assessed. Data indicated a large variation in fatty acid profile and conjugated linoleic acid composition among edible by-products...
April 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28341293/marine-protected-communities-against-biological-invasions-a-case-study-from-an-offshore-island
#9
I Gestoso, P Ramalhosa, P Oliveira, J Canning-Clode
Biological invasions are a major threat to the world's biota and are considered a major cause of biodiversity loss. Therefore, world marine policy has recognized the need for more marine protected areas (MPAs) as a major tool for biodiversity conservation. The present work experimentally evaluated how protected communities from an offshore island can face the settlement and/or expansion of nonindigenous species (NIS). First, NIS colonization success in marine protected and marina communities was compared by deploying PVC settling plates at the Garajau MPA and Funchal marina (SW Madeira Island)...
March 21, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28331390/cryptorchestia-ruffoi-sp-n-from-the-island-of-rhodes-greece-revealed-by-morphological-and-phylogenetic-analysis-crustacea-amphipoda-talitridae
#10
Domenico Davolos, Elvira De Matthaeis, Leonardo Latella, Ronald Vonk
A new Cryptorchestia species, Cryptorchestia ruffoi Latella & Vonk, sp. n. from the island of Rhodes in south-eastern Greece, can be distinguished on the basis of morphological and phylogenetic data. Morphological analysis and DNA sequencing of mitochondrial and nuclear protein-coding genes indicated that this species is related to Cryptorchestia cavimana (Cyprus) and Cryptorchestia garbinii (Mediterranean regions, with a recent northward expansion). Results supported a genetic separation between the Cryptorchestia species of the east Mediterranean regions and those of the northeast Atlantic volcanic islands examined in this study (Cryptorchestia canariensis, Cryptorchestia gomeri, Cryptorchestia guancha, and Cryptorchestia stocki from the Canary islands, Cryptorchestia monticola from Madeira, and Cryptorchestia chevreuxi from the Azores)...
2017: ZooKeys
https://www.readbyqxmd.com/read/28331386/phylogenetic-analysis-of-the-genus-laparocerus-with-comments-on-colonisation-and-diversification-in-macaronesia-coleoptera-curculionidae-entiminae
#11
Antonio Machado, Eduardo Rodríguez-Expósito, Mercedes López, Mariano Hernández
The flightless Entiminae weevil genus Laparocerus is the species-richest genus, with 237 species and subspecies, inhabiting Macaronesia (Madeira archipelago, Selvagens, Canary Islands) and the continental 'Macaronesian enclave' in Morocco (one single polytypic species). This is the second contribution to gain insight of the genus and assist in its systematic revision with a mitochondrial phylogenetic analysis. It centres on the Canarian clade, adding the 12S rRNA gene to the combined set of COII and 16S rRNA used in our first contribution on the Madeiran clade (here re-analysed)...
2017: ZooKeys
https://www.readbyqxmd.com/read/28321363/high-unexpected-genetic-diversity-of-a-narrow-endemic-terrestrial-mollusc
#12
Pedro M Madeira, Rosa M Chefaoui, Regina L Cunha, Francisco Moreira, Susana Dias, Gonçalo Calado, Rita Castilho
The Iberian Peninsula has an extensive record of species displaying strong genetic structure as a result of their survival in isolated pockets throughout the Pleistocene ice ages. We used mitochondrial and nuclear sequence data to analyze phylogeographic patterns in endemic land snails from a valley of central Portugal (Vale da Couda), putatively assigned to Candidula coudensis, that show an exceptionally narrow distributional range. The genetic survey presented here shows the existence of five main mitochondrial lineages in Vale da Couda that do not cluster together suggesting independent evolutionary histories...
2017: PeerJ
https://www.readbyqxmd.com/read/28317726/effects-of-whey-protein-concentrate-feed-moisture-and-temperature-on-the-physicochemical-characteristics-of-a-rice-based-extruded-flour
#13
Carla da Silva Teba, Erika Madeira Moreira da Silva, Davy William Hidalgo Chávez, Carlos Wanderlei Piler de Carvalho, José Luis Ramírez Ascheri
The influence of whey protein concentrate (WPC), feed moisture and temperature on the physicochemical properties of rice-based extrudates has been investigated. WPC (0.64-7.36g/100g rice) was extruded under 5 moisture (16.64-23.36g/100g) and 5 temperature (106.36-173.64°C) established by a 3(2) central composite rotational design. Physicochemical properties [color, porosimetry, crystallinity, water solubility and absorption, pasting properties, reconstitution test, proximate composition, amino acids, minerals and electrophoresis] were determined...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28295329/anatomy-of-the-lobula-complex-in-the-brain-of-the-praying-mantis-compared-to-the-lobula-complexes-of-the-locust-and-cockroach
#14
Ronny Rosner, Joss von Hadeln, Tobias Salden, Uwe Homberg
The praying mantis is an insect which relies on vision for capturing prey, avoiding being eaten and for spatial orientation. It is well known for its ability to use stereopsis for estimating the distance of objects. The neuronal substrate mediating visually driven behaviors, however, is not very well investigated. To provide a basis for future functional studies, we analyzed the anatomical organization of visual neuropils in the brain of the praying mantis Hierodula membranacea and provide supporting evidence from a second species, Rhombodera basalis, with particular focus on the lobula complex...
March 15, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28288690/dirofilaria-immitis-in-pinnipeds-and-a%C3%A2-new-host-record
#15
Ana Margarida Alho, Inês Marcelino, Vito Colella, Carla Flanagan, Nuno Silva, Jorge Jesus Correia, Maria Stefania Latrofa, Domenico Otranto, Luís Madeira de Carvalho
BACKGROUND: Dirofilaria immitis is a mosquito-borne pathogen that is spreading worldwide, and the associated infection (i.e. dirofilariosis) is becoming a threat to animals and humans living in endemic areas. Little is known about the occurrence and risk of infection of D. immitis in pinnipeds. Here we report dirofilariosis by D. immitis in several pinniped species kept in captivity in Portugal. METHODS: Animals were housed in an oceanographic park located in Algarve, southern Portugal, a geographical area endemic for canine dirofilariosis...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28286537/smoking-and-antidepressants-pharmacokinetics-a-systematic-review
#16
REVIEW
Pedro Oliveira, Joana Ribeiro, Helena Donato, Nuno Madeira
BACKGROUND: Despite an increasingly recognized relationship between depression and smoking, little is known about how smoking influences antidepressant response and treatment outcomes. The aim of this study was to systematically review the evidence of the impact of smoking on new-generation antidepressants with an emphasis on the pharmacokinetic perspective. METHODS: We present a systematic review of clinical trials comparing the serum levels of new-generation antidepressants in smokers and nonsmokers...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28280483/outer-plexiform-layer-structures-are-not-altered-following-aav-mediated-gene-transfer-in-healthy-rat-retina
#17
Bert C Giers, Daniela Klein, Alexandra Mendes-Madeira, Carolina Isiegas, Birgit Lorenz, Silke Haverkamp, Knut Stieger
Ocular gene therapy approaches have been developed for a variety of different diseases. In particular, clinical gene therapy trials for RPE65 mutations, X-linked retinoschisis, and choroideremia have been conducted at different centers in recent years, showing that adeno-associated virus (AAV)-mediated gene therapy is safe, but limitations exist as to the therapeutic benefit and long-term duration of the treatment. The technique of vector delivery to retinal cells relies on subretinal injection of the vector solution, causing a transient retinal detachment...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28279148/erratum-to-bicpams-software-for-biological-data-analysis-with-pattern-based-biclustering
#18
Rui Henriques, Francisco L Ferreira, Sara C Madeira
No abstract text is available yet for this article.
March 9, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28259879/basic-self-disturbances-beyond-schizophrenia-discrepancies-and-affinities-in-panic-disorder-an-empirical-clinical-study
#19
Luís Madeira, Sergio Carmenates, Cristina Costa, Ludgero Linhares, Giovanni Stanghellini, Maria Luísa Figueira, Louis Sass
BACKGROUND: Anomalous self-experiences (ASEs), presumably involving alterations in "core" or "minimal self," have been studied as manifest in schizophrenia and its spectrum, in contrast with mood disorder and personality disorder samples. This is the first study to examine ASEs in panic disorder (PD), beginning the exploration of these disturbances of subjectivity in anxiety disorders. We aimed to clarify what might, or might not, be specific to the schizophrenia spectrum domain - which, in turn, could be useful for developing pathogenetic models for various disorders...
March 3, 2017: Psychopathology
https://www.readbyqxmd.com/read/28252959/microscale-high-throughput-experimentation-as-an-enabling-technology-in-drug-discovery-application-in-the-discovery-of-piperidinyl-pyridinyl-1h-benzimidazole-diacylglycerol-acyltransferase-1-inhibitors
#20
Tim Cernak, Nathan J Gesmundo, Kevin Dykstra, Yang Yu, Zhicai Wu, Zhi-Cai Shi, Petr Vachal, Donald Sperbeck, Shuwen He, Beth Ann Murphy, Lisa Sonatore, Steven Williams, Maria Madeira, Andreas Verras, Maud Reiter, Claire Heechoon Lee, James Cuff, Edward C Sherer, Jeffrey Kuethe, Stephen Goble, Nicholas Perrotto, Shirly Pinto, Dong-Ming Shen, Ravi Nargund, James Balkovec, Robert J DeVita, Spencer D Dreher
Miniaturization and parallel processing play an important role in the evolution of many technologies. We demonstrate the application of miniaturized high-throughput experimentation methods to resolve synthetic chemistry challenges on the frontlines of a lead optimization effort to develop diacylglycerol acyltransferase (DGAT1) inhibitors. Reactions were performed on ∼1 mg scale using glass microvials providing a miniaturized high-throughput experimentation capability that was used to study a challenging SNAr reaction...
March 2, 2017: Journal of Medicinal Chemistry
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