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https://www.readbyqxmd.com/read/28222159/the-role-of-spatial-mobility-in-malaria-transmission-in-the-brazilian-amazon-the-case-of-porto-velho-municipality-rond%C3%A3-nia-brazil-2010-2012
#1
Jussara Rafael Angelo, Tony Hiroshi Katsuragawa, Paulo Chagastelles Sabroza, Lino Augusto Sander de Carvalho, Luiz Hildebrando Pereira da Silva, Carlos Afonso Nobre
BACKGROUND: This study aims to describe the role of mobility in malaria transmission by discussing recent changes in population movements in the Brazilian Amazon and developing a flow map of disease transmission in this region. METHODOLOGY/PRINCIPAL FINDINGS: This study presents a descriptive analysis using an ecological approach on regional and local scales. The study location was the municipality of Porto Velho, which is the capital of Rondônia state, Brazil...
2017: PloS One
https://www.readbyqxmd.com/read/28215839/unraveling-the-etiology-of-ovarian-cancer-racial-disparity-in-the-deep-south-is-it-nature-or-nurture
#2
Jerlinda Ross, Katelyn V Braswell, Luciana Madeira da Silva, Frances Mujica, Sam Stutsman, Michael A Finan, William Nicolson, Mary Danner Harmon, Megan Missanelli, Alex Cohen, Ajay Singh, Jennifer M Scalici, Rodney P Rocconi
BACKGROUND: Our objective was to evaluate racial treatment and survival disparities in black women with ovarian cancer in the Deep South and to determine how environmental factors / socioeconomic status (SES) influence survival. METHODS: A retrospective study of ovarian cancer patients from 2007 to 2014 was performed. Socioeconomic status (SES) was obtained though U.S. Census block data and compared using Yost scores. Comparisons were performed using standard statistical approaches...
February 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28196934/mortality-of-adult-critically-ill-subjects-with-cancer
#3
Regis Goulart Rosa, Tulio Frederico Tonietto, Bruno Achutti Duso, Juçara Gasparetto Maccari, Roselaine Pinheiro de Oliveira, William Rutzen, Laura Madeira, Aline Ascoli, Rachel Hessler, Paola Morandi, Ricardo Viegas Cremonese, Felippe Leopoldo Dexheimer Neto, Luciana Tagliari, Patrícia de Campos Balzano, José Hervê Diel Barth, Cassiano Teixeira
BACKGROUND: Cancer patients may require intensive care support for postoperative care, complications associated with underlying malignancy, or toxicities related to cancer therapy. The higher mortality rates found in this population than in the population of ICU patients without cancer may be attributable to confounding due to a higher prevalence of multiple organic dysfunctions at ICU admission in patients with malignancy; however, data regarding this hypothesis are scarce. Accordingly, we performed the present study to compare the crude and propensity score-matched mortality rates between adult subjects with and without cancer admitted to a mixed medical-surgical ICU...
February 14, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28187663/-i-hyphessobrycon-i-i-petricolus-i-a-new-species-of-tetra-characiformes-characidae-from-the-rio-madeira-basin-mato-grosso-brazil
#4
Willian M Ohara, Flávio C T Lima, Bruno S Barros
A new species of Hyphessobrycon is described from the rio Roosevelt, rio Madeira basin, Mato Grosso State, Brazil. Hyphessobrycon petricolus sp. n. can be distinguished from its congeners by the unique combination of the following features: a well-defined, relatively narrow dark midlateral stripe on body extending from immediately behind posterior margin of opercle to the middle caudal-fin rays, relatively conspicuous humeral blotch, and 16-20 branched anal-fin rays. Comments on the remaining Hyphessobrycon species presenting a conspicuous dark midlateral stripe are presented...
January 17, 2017: Zootaxa
https://www.readbyqxmd.com/read/28187361/toxicity-of-abamectin-and-difenoconazole-mixtures-to-a-neotropical-cladoceran-after-simulated-run-off-and-spray-drift-exposure
#5
Raquel Aparecida Moreira, Michiel Adriaan Daam, Bruna Horvath Vieira, Ana Letícia Madeira Sanches, Marina Vanderlei Reghini, Adrislaine da Silva Mansano, Emanuela Cristina de Freitas, Evaldo Luiz Gaeta Espindola, Odete Rocha
Aquatic risk assessments of pesticides in tropical countries have often been disputed for being largely based on risk evaluations conducted in temperate regions. Although pesticide sensitivity comparisons between temperate and tropical freshwater organisms have indeed not revealed consistent differences, risk assessments are currently still based on a relatively small tropical toxicity dataset. In addition, greater levels of runoff and spray drift may be expected in tropical than in temperate agroecosystems, indicating that aquatic life in edge-of-field water bodies is likely to be subjected to higher concentrations of pesticides and their mixtures...
February 3, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28187167/the-sociodemographic-behavioral-reproductive-and-health-factors-associated-with-fertility-in-brazil
#6
Cesar Augusto Oviedo Tejada, Lívia Madeira Triaca, Flávia Katrein da Costa, Franciele Hellwig
High fertility rates among disadvantaged subgroups are a public health problem because fertility levels significantly affect socioeconomic conditions and a population's welfare. This paper aims to analyze the sociodemographic, behavioral, and reproductive factors associated with fertility rates among Brazilian women aged between 15-49 years. A Poisson regression was used to analyze data from the 2006 PNDS (Pesquisa Nacional de Demografia e Saúde da Criança e da Mulher), which evaluates socioeconomic, demographic, geographic, reproductive, behavioral, and chronic disease variables...
2017: PloS One
https://www.readbyqxmd.com/read/28174566/application-of-a-dot-blot-hybridization-platform-to-assess-streptococcus-uberis-population-structure-in-dairy-herds
#7
Pedro Albuquerque, Niza Ribeiro, Alexandre Almeida, Irena Panschin, Afonso Porfirio, Marta Vales, Francisca Diniz, Helena Madeira, Fernando Tavares
Streptococcus uberis is considered one of the most important pathogens associated with bovine mastitis. While traditionally acknowledged as an environmental pathogen, S. uberis has been shown to adopt a contagious epidemiological pattern in several dairy herds. Since different control strategies are employed depending on the mode of transmission, in-depth studies of S. uberis populations are essential to determine the best practices to control this pathogen. In this work, we optimized and validated a dot blot platform, combined with automatic image analysis, to rapidly assess the population structure of infective S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28169160/corrigendum-to-discovery-of-benzofuran-propanoic-acid-gpr120-agonists-from-uhts-hit-to-mechanism-based-pharmacodynamic-effects-bioorg-med-chem-lett-26-2016-5724-5728
#8
Matthew Lombardo, Kate Bender, Clare London, Michael A Plotkin, Melissa Kirkland, Joel Mane, Michele Pachanski, Wayne Geissler, John Cummings, Bahanu Habulihaz, Taro E Akiyama, Jerry Di Salvo, Maria Madeira, Joanna Pols, Mary Ann Powles, Michael F Finley, Eric Johnson, Thomas Roussel, Victor N Uebele, Alejandro Crespo, Dennis Leung, Candice Alleyne, Dorina Trusca, Ying Lei, Andrew D Howard, Feroze Ujjainwalla, James R Tata, Christopher J Sinz
No abstract text is available yet for this article.
February 4, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28153040/bicpams-software-for-biological-data-analysis-with-pattern-based-biclustering
#9
Rui Henriques, Francisco L Ferreira, Sara C Madeira
BACKGROUND: Biclustering has been largely applied for the unsupervised analysis of biological data, being recognised today as a key technique to discover putative modules in both expression data (subsets of genes correlated in subsets of conditions) and network data (groups of coherently interconnected biological entities). However, given its computational complexity, only recent breakthroughs on pattern-based biclustering enabled efficient searches without the restrictions that state-of-the-art biclustering algorithms place on the structure and homogeneity of biclusters...
February 2, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28152397/the-effects-of-perceptual-load-in-processing-emotional-facial-expression-in-psychotic-disorders
#10
Joana Grave, Sandra C Soares, Sofia Morais, Paulo Rodrigues, Nuno Madeira
Psychotic disorders are some of the most severe psychiatric conditions. Patients have difficulties in identifying facial expressions and appear to be highly sensitive to the presence of emotional distractors. Yet, no study has investigated whether perceptual load modulates the interference of emotional distractors. Our goal was to test whether psychotic patients were more sensitive to irrelevant emotional stimulus, even when the task demands a high amount of attentional resources. Twenty-two participants with schizophrenia or schizoaffective disorder and twenty-two healthy controls, performed a target letter discrimination task with emotional task-irrelevant stimulus (angry, happy and neutral facial expressions)...
January 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28150720/drivers-of-cape-verde-archipelagic-endemism-in-keyhole-limpets
#11
Regina L Cunha, Jorge M Assis, Celine Madeira, Rui Seabra, Fernando P Lima, Evandro P Lopes, Suzanne T Williams, Rita Castilho
Oceanic archipelagos are the ideal setting for investigating processes that shape species assemblages. Focusing on keyhole limpets, genera Fissurella and Diodora from Cape Verde Islands, we used an integrative approach combining molecular phylogenetics with ocean transport simulations to infer species distribution patterns and analyse connectivity. Dispersal simulations, using pelagic larval duration and ocean currents as proxies, showed a reduced level of connectivity despite short distances between some of the islands...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28138299/bees-of-the-azores-an-annotated-checklist-apidae-hymenoptera
#12
Julie A Weissmann, Ana Picanço, Paulo A V Borges, Hanno Schaefer
We report 18 species of wild bees plus the domesticated honeybee from the Azores, which adds nine species to earlier lists. One species, Hylaeus azorae, seems to be a single island endemic, and three species are possibly native (Colletes eous, Halictus villosulus, and Hylaeus pictipes). All the remaining bee species are most likely accidental introductions that arrived after human colonization of the archipelago in the 15(th) century. Bee diversity in the Azores is similar to bee diversity of Madeira and Cape Verde but nearly ten times lower than it is in the Canary Islands...
2017: ZooKeys
https://www.readbyqxmd.com/read/28133820/dietary-inclusion-of-tomato-pomace-improves-meat-oxidative-stability-of-young-pigs
#13
C S Correia, C M Alfaia, M S Madeira, P A Lopes, T J S Matos, L F Cunha, J A M Prates, J P B Freire
The aim of this study was to assess the nutritional effect of tomato pomace, in combination with two distinct fat sources (lard or soya bean oil), on longissimus lumborum muscle, subcutaneous fat and liver of young pigs. Forty male pigs of 4 weeks old were randomly assigned to four dietary treatments using two fibre sources (wheat bran or 5.0% tomato pomace) and two fat sources (lard or soya bean oil), in a 2 × 2 factorial design for a 5-week trial. Tomato pomace did not improve colour, fatty acid profile, cholesterol content or lipid oxidation, nor did it yield detectable levels in lycopene or β-carotene in the meat (p > 0...
January 30, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28116071/plant-invasion-and-speciation-along-elevational-gradients-on-the-oceanic-island-la-palma-canary-islands
#14
Manuel J Steinbauer, Severin D H Irl, Juana María González-Mancebo, Frank T Breiner, Raquel Hernández-Hernández, Sebastian Hopfenmüller, Yohannes Kidane, Anke Jentsch, Carl Beierkuhnlein
Ecosystems that provide environmental opportunities but are poor in species and functional richness generally support speciation as well as invasion processes. These processes are expected not to be equally effective along elevational gradients due to specific ecological, spatial, and anthropogenic filters, thus controlling the dispersal and establishment of species. Here, we investigate speciation and invasion processes along elevational gradients. We assess the vascular plant species richness as well as the number and percentage of endemic species and non-native species systematically along three elevational gradients covering large parts of the climatic range of La Palma, Canary Islands...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28105282/discovery-of-chromane-propionic-acid-analogues-as-selective-agonists-of-gpr120-with-in-vivo-activity-in-rodents
#15
Gregory L Adams, Francisco Velazquez, Charles Jayne, Unmesh Shah, Shouwu Miao, Eric R Ashley, Maria Madeira, Taro E Akiyama, Jerry Di Salvo, Takao Suzuki, Nengxue Wang, Quang Truong, Eric Gilbert, Dan Zhou, Andreas Verras, Melissa Kirkland, Michele Pachanski, Maryann Powles, Wu Yin, Feroze Ujjainwalla, Srikanth Venkatraman, Scott D Edmondson
GPR120 (FFAR4) is a fatty acid sensing G protein coupled receptor (GPCR) that has been identified as a target for possible treatment of type 2 diabetes. A selective activator of GPR120 containing a chromane scaffold has been designed, synthesized, and evaluated in vivo. Results of these efforts suggest that chromane propionic acid 18 is a suitable tool molecule for further animal studies. Compound 18 is selective over the closely related target GPR40 (FFAR1), has a clean off-target profile, demonstrates suitable pharmacokinetic properties, and has been evaluated in wild-type/knockout GPR120 mouse oGTT studies...
January 12, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28105274/design-synthesis-and-evaluation-of-novel-and-selective-g-protein-coupled-receptor-120-gpr120-spirocyclic-agonists
#16
Jason M Cox, Hong D Chu, Mariappan V Chelliah, John S Debenham, Keith Eagen, Ping Lan, Matthew Lombardo, Clare London, Michael A Plotkin, Unmesh Shah, Zhongxiang Sun, Henry M Vaccaro, Srikanth Venkatraman, Takao Suzuki, Nengxue Wang, Eric R Ashley, Alejandro Crespo, Maria Madeira, Dennis H Leung, Candice Alleyne, Aimie M Ogawa, Sarah Souza, Brande Thomas-Fowlkes, Jerry Di Salvo, Adam Weinglass, Melissa Kirkland, Michele Pachanski, Mary Ann Powles, Effie Tozzo, Taro E Akiyama, Feroze Ujjainwalla, James R Tata, Christopher J Sinz
Type 2 diabetes mellitus (T2DM) is an ever increasing worldwide epidemic, and the identification of safe and effective insulin sensitizers, absent of weight gain, has been a long-standing goal of diabetes research. G-protein coupled receptor 120 (GPR120) has recently emerged as a potential therapeutic target for treating T2DM. Natural occurring, and more recently, synthetic agonists have been associated with insulin sensitizing, anti-inflammatory, and fat metabolism effects. Herein we describe the design, synthesis, and evaluation of a novel spirocyclic GPR120 agonist series, which culminated in the discovery of potent and selective agonist 14...
January 12, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28103304/correction-the-fatty-acid-synthase-inhibitor-platensimycin-improves-insulin-resistance-without-inducing-liver-steatosis-in-mice-and-monkeys
#17
Sheo B Singh, Ling Kang, Andrea R Nawrocki, Dan Zhou, Margaret Wu, Stephen Previs, Corey Miller, Haiying Liu, Catherine D G Hines, Maria Madeira, Jin Cao, Kithsiri Herath, Larry D Spears, Clay F Semenkovich, Liangsu Wang, David E Kelley, Cai Li, Hong-Ping Guan
[This corrects the article DOI: 10.1371/journal.pone.0164133.].
2017: PloS One
https://www.readbyqxmd.com/read/28080959/sentinel-surveillance-of-imported-dengue-via-travellers-to-europe-2012-to-2014-tropnet-data-from-the-denguetools-research-initiative
#18
Andreas Neumayr, Jose Muñoz, Mirjam Schunk, Emmanuel Bottieau, Jakob Cramer, Guido Calleri, Rogelio López-Vélez, Andrea Angheben, Thomas Zoller, Leo Visser, Núria Serre-Delcor, Blaise Genton, Francesco Castelli, Marjan Van Esbroeck, Alberto Matteelli, Laurence Rochat, Elena Sulleiro, Florian Kurth, Federico Gobbi, Francesca Norman, Ilaria Torta, Jan Clerinx, David Poluda, Miguel Martinez, Antonia Calvo-Cano, Maria Paz Sanchez-Seco, Annelies Wilder-Smith, Christoph Hatz, Leticia Franco
We describe the epidemiological pattern and genetic characteristics of 242 acute dengue infections imported to Europe by returning travellers from 2012 to 2014. The overall geographical pattern of imported dengue (South-east Asia > Americas > western Pacific region > Africa) remained stable compared with 1999 to 2010. We isolated the majority of dengue virus genotypes and epidemic lineages causing outbreaks and epidemics in Asia, America and Africa during the study period. Travellers acted as sentinels for four unusual dengue outbreaks (Madeira, 2012-13; Luanda, 2013; Dar es Salaam, 2014; Tokyo, 2014)...
January 5, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28076367/a-chemogenomic-screen-reveals-novel-snf1p-ampk-independent-regulators-of-acetyl-coa-carboxylase
#19
Bruno L Bozaquel-Morais, Juliana B Madeira, Thiago M Venâncio, Thiago Pacheco-Rosa, Claudio A Masuda, Monica Montero-Lomeli
Acetyl-CoA carboxylase (Acc1p) is a key enzyme in fatty acid biosynthesis and is essential for cell viability. To discover new regulators of its activity, we screened a Saccharomyces cerevisiae deletion library for increased sensitivity to soraphen A, a potent Acc1p inhibitor. The hits identified in the screen (118 hits) were filtered using a chemical-phenotype map to exclude those associated with pleiotropic drug resistance. This enabled the identification of 82 ORFs that are genetic interactors of Acc1p. The main functional clusters represented by these hits were "transcriptional regulation", "protein post-translational modifications" and "lipid metabolism"...
2017: PloS One
https://www.readbyqxmd.com/read/28070469/leukocytoclastic-vasculitis-with-systemic-involvement-associated-with-ciprofloxacin-therapy-case-report-and-review-of-the-literature
#20
REVIEW
Bruno Morgado, Catarina Madeira, Joana Pinto, Joana Pestana
A 71-year-old woman presented with constitutional signs and lower extremity palpable purpura after being prescribed a four-day course of 500 mg of ciprofloxacin two times daily for a gastrointestinal infection. She was admitted for inpatient treatment. During the third hospital day, she presented with an episode of abundant hematemesis while her skin lesions remained unchanged. Upper endoscopy revealed multiple lesions consistent with vasculitis and histological examination of the skin biopsy disclosed a leukocytoclastic vasculitis...
November 28, 2016: Curēus
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