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https://www.readbyqxmd.com/read/28080959/sentinel-surveillance-of-imported-dengue-via-travellers-to-europe-2012-to-2014-tropnet-data-from-the-denguetools-research-initiative
#1
Andreas Neumayr, Jose Muñoz, Mirjam Schunk, Emmanuel Bottieau, Jakob Cramer, Guido Calleri, Rogelio López-Vélez, Andrea Angheben, Thomas Zoller, Leo Visser, Núria Serre-Delcor, Blaise Genton, Francesco Castelli, Marjan Van Esbroeck, Alberto Matteelli, Laurence Rochat, Elena Sulleiro, Florian Kurth, Federico Gobbi, Francesca Norman, Ilaria Torta, Jan Clerinx, David Poluda, Miguel Martinez, Antonia Calvo-Cano, Maria Paz Sanchez-Seco, Annelies Wilder-Smith, Christoph Hatz, Leticia Franco
We describe the epidemiological pattern and genetic characteristics of 242 acute dengue infections imported to Europe by returning travellers from 2012 to 2014. The overall geographical pattern of imported dengue (South-east Asia > Americas > western Pacific region > Africa) remained stable compared with 1999 to 2010. We isolated the majority of dengue virus genotypes and epidemic lineages causing outbreaks and epidemics in Asia, America and Africa during the study period. Travellers acted as sentinels for four unusual dengue outbreaks (Madeira, 2012-13; Luanda, 2013; Dar es Salaam, 2014; Tokyo, 2014)...
January 5, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28076367/a-chemogenomic-screen-reveals-novel-snf1p-ampk-independent-regulators-of-acetyl-coa-carboxylase
#2
Bruno L Bozaquel-Morais, Juliana B Madeira, Thiago M Venâncio, Thiago Pacheco-Rosa, Claudio A Masuda, Monica Montero-Lomeli
Acetyl-CoA carboxylase (Acc1p) is a key enzyme in fatty acid biosynthesis and is essential for cell viability. To discover new regulators of its activity, we screened a Saccharomyces cerevisiae deletion library for increased sensitivity to soraphen A, a potent Acc1p inhibitor. The hits identified in the screen (118 hits) were filtered using a chemical-phenotype map to exclude those associated with pleiotropic drug resistance. This enabled the identification of 82 ORFs that are genetic interactors of Acc1p. The main functional clusters represented by these hits were "transcriptional regulation", "protein post-translational modifications" and "lipid metabolism"...
2017: PloS One
https://www.readbyqxmd.com/read/28070469/leukocytoclastic-vasculitis-with-systemic-involvement-associated-with-ciprofloxacin-therapy-case-report-and-review-of-the-literature
#3
REVIEW
Bruno Morgado, Catarina Madeira, Joana Pinto, Joana Pestana
A 71-year-old woman presented with constitutional signs and lower extremity palpable purpura after being prescribed a four-day course of 500 mg of ciprofloxacin two times daily for a gastrointestinal infection. She was admitted for inpatient treatment. During the third hospital day, she presented with an episode of abundant hematemesis while her skin lesions remained unchanged. Upper endoscopy revealed multiple lesions consistent with vasculitis and histological examination of the skin biopsy disclosed a leukocytoclastic vasculitis...
November 28, 2016: Curēus
https://www.readbyqxmd.com/read/28032448/hla-dqa1-and-hla-dqb1-allele-diversity-and-its-extended-haplotypes-in-madeira-island-portugal
#4
H Spínola, A Lemos, A R Couto, B Parreira, M Soares, I Dutra, J Bruges-Armas, A Brehm
This study shows, for the first time, high-resolution allele frequencies of HLA-DQA1 loci in Madeira Island (Portugal) and allows us to better understand and refine present knowledge on DQB1 variation, with the identification of several alleles not previously reported in this population. Estimates on haplotype profile, involving HLA-A, HLA-B, HLA-DRB1, HLA-DQA1 and HLA-DQB1, are also reported.
December 29, 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28024281/photodynamic-therapy-mediated-by-acai-oil-euterpe-oleracea-martius-in-nanoemulsion-a-potential-treatment-for-melanoma
#5
Victoria Monge-Fuentes, Luis Alexandre Muehlmann, João Paulo Figueiró Longo, Jaqueline Rodrigues Silva, Maria Luiza Fascineli, Paulo de Souza, Fernando Faria, Igor Anatolievich Degterev, Anselmo Rodriguez, Fabiana Pirani Carneiro, Carolina Madeira Lucci, Patricia Escobar, Rivadávio Fernandes Batista Amorim, Ricardo Bentes Azevedo
Melanoma is the most aggressive and lethal form of skin cancer, responsible for >80% of deaths. Standard treatments for late-stage melanoma usually present poor results, leading to life-threatening side effects and low overall survival. Thus, it is necessary to rethink treatment strategies and design new tools for the treatment of this disease. On that ground, we hereby report the use of acai oil in nanoemulsion (NanoA) as a novel photosensitizer for photodynamic therapy (PDT) used to treat melanoma in in vitro and in vivo experimental models...
January 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27975720/endemic-asteraceae-from-madeira-archipelago-a-relation-of-hypoglycemic-activity-to-their-polyphenolic-composition
#6
V Spínola, S Gouveia-Figueira, P C Castilho
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27955714/selection-of-porcine-oocytes-in-vitro-through-brilliant-cresyl-blue-staining-in-distinct-incubation-media
#7
Elisa C S Santos, Jorgea Pradieé, Elisângela M Madeira, Miriane M Pereira, Bruna Mion, Rafael G Mondadori, Arnaldo D Vieira, Ligia M C Pegoraro, Thomaz Lucia
Staining with brilliant cresyl blue (BCB) may be used for oocyte selection, but BCB staining itself and the most commonly used selection medium (DMPBS) may compromise the development of porcine oocytes in vitro. This study evaluated DNA fragmentation, nuclear maturation, the area of migration of cortical granules (CG) and embryo development for stained (BCB+) and unstained (BCB-) oocytes incubated in DMPBS and in a modified medium (ReproPel) tested for the first time. Unexposed (UN), BCB+ and BCB- oocytes were incubated composing six groups: DMPBS/UN; DMPBS/BCB+; DMPBS/BCB-; ReproPel/UN; ReproPel/BCB+; and ReproPel/BCB-...
February 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/27941988/genetic-and-morphological-variation-of-the-forkbeard-phycis-phycis-pisces-phycidae-evidence-of-panmixia-and-recent-population-expansion-along-its-distribution-area
#8
Ana Rita Vieira, Ana Sofia B Rodrigues, Vera Sequeira, Ana Neves, Rafaela Barros Paiva, Octávio S Paulo, Leonel Serrano Gordo
The knowledge of population structure of a species is essential to effectively assess and manage fisheries. In the present study, genetics, by mitochondrial DNA cytochrome b sequence analysis, and body geometric morphometrics were used to evaluate the existence of distinct populations of the forkbeard (Phycis phycis), an important commercial species in several European countries, especially Portugal and Spain. For geometric morphometric analysis, specimens were collected in the Northeast Atlantic Ocean-Azores, Madeira and mainland Portugal, and for genetic analysis, these samples were complemented with samples collected in the Mediterranean Sea-Spain, Italy and Croatia, in order to cover the entire distribution area of the species...
2016: PloS One
https://www.readbyqxmd.com/read/27917052/the-blowflies-of-the-madeira-archipelago-species-diversity-distribution-and-identification-diptera-calliphoridaes-l
#9
Catarina Prado E Castro, Krzysztof Szpila, Anabel Martínez-Sánchez, Rego, Isamberto Silva, Artur R M Serrano, Mário Boieiro
Knowledge on the taxonomic diversity and distribution of blowflies from the Madeira Archipelago is updated. New and interesting findings are reported for poorly studied islands and islets of this archipelago, together with a brief analysis of the diversity of Macaronesian Calliphoridae s. l. Seven blowfly species were collected during this study, including the first records of Calliphora vicina Robineau-Desvoidy, 1830, Chrysomya albiceps (Wiedemann, 1819), Lucilia sericata (Meigen, 1826), Pollenia rudis (Fabricius, 1794) and Stomorhina lunata (Fabricius, 1805) from Porto Santo, and of Calliphora vicina, Lucilia sericata and Stomorhina lunata from Desertas Islands...
2016: ZooKeys
https://www.readbyqxmd.com/read/27914747/sporothrix-schenckii-sensu-lato-identification-in-fragments-of-skin-lesion-cultured-in-nnn-medium-for-differential-diagnosis-of-cutaneous-leishmaniasis
#10
Liliane de Fátima Antonio, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra, Maria de Fátima Madeira, Luciana de Freitas Campos Miranda, Rodrigo Almeida Paes, Fábio Brito-Santos, Maria Helena Galdino Figueredo Carvalho, Armando de Oliveira Schubach
Eighty-nine patients with clinical suspicion of leishmaniasis were referred for differential diagnosis. Sporothrix schenckii sensu lato was isolated in Novy-MacNeal-Nicolle + Schneider media in 98% of 64 patients with final diagnosis of sporotrichosis. This medium may be suitable for diagnosis of sporotrichosis in areas where cutaneous leishmaniasis is also endemic.
February 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27912797/helminth-infections-and-gut-microbiota-a-feline-perspective
#11
Ana M Duarte, Timothy P Jenkins, Maria S Latrofa, Alessio Giannelli, Elias Papadopoulos, Luís Madeira de Carvalho, Matthew J Nolan, Domenico Otranto, Cinzia Cantacessi
BACKGROUND: Investigations of the relationships between the gut microbiota and gastrointestinal parasitic nematodes are attracting growing interest by the scientific community, driven by the need to better understand the contribution of parasite-associated changes in the composition of the gut flora to both host malnutrition and immune modulation. These studies have however been carried out mainly in humans and experimental animals, while knowledge of the make-up of the gut commensal flora in presence or absence of infection by parasitic nematodes in domestic animals is limited...
December 3, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27905975/health-profile-of-centenarians-in-portugal-a-census-based-approach
#12
Oscar Ribeiro, Laetitia Teixeira, Lia Araújo, Constança Paúl
BACKGROUND: The number of centenarians is rapidly increasing in Europe. In Portugal, it has almost tripled over the last 10 years and constitutes one of the fastest-growing segments of the population. This paper aims to describe the health and sociodemographic characteristics of Portuguese centenarians as given in the 2011 census and to identify sex differences. METHODS: All persons living in Portugal mainland and Madeira and Azores islands aged 100 years old at the time of the 2011 census (N = 1,526) were considered...
April 12, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27894882/comparing-biomarker-responses-during-thermal-acclimation-a-lethal-vs-non-lethal-approach-in-a-tropical-reef-clownfish
#13
Carolina Madeira, Diana Madeira, Mário S Diniz, Henrique N Cabral, Catarina Vinagre
Knowledge of thermal stress biology for most tropical fish species in reef ecosystems under climate change is still quite limited. Thus, the objective of this study was to measure the time-course changes of thermal stress biomarkers in the commercially exploited coral reef fish Amphiprion ocellaris, during a laboratory simulated event of increased temperature. Heat shock protein 70kDa (Hsp70) and total ubiquitin (Ub) were determined in the muscle (lethal method) and in the fin (non-lethal alternative method) under two temperature treatments (control - 26°C and elevated temperature - 30°C) throughout one month with weekly samplings...
February 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27888674/qpcr-detection-of-mycobacterium-leprae-in-biopsies-and-slit-skin-smear-of-different-leprosy-clinical-forms
#14
Michelle de Campos Soriani Azevedo, Natália Mortari Ramuno, Luciana Raquel Vincenzi Fachin, Mônica Tassa, Patrícia Sammarco Rosa, Andrea de Faria Fernandes Belone, Suzana Madeira Diório, Cleverson Teixeira Soares, Gustavo Pompermaier Garlet, Ana Paula Favaro Trombone
Leprosy, whose etiological agent is Mycobacterium leprae, is a chronic infectious disease that mainly affects the skin and peripheral nervous system. The diagnosis of leprosy is based on clinical evaluation, whereas histopathological analysis and bacilloscopy are complementary diagnostic tools. Quantitative PCR (qPCR), a current useful tool for diagnosis of infectious diseases, has been used to detect several pathogens including Mycobacterium leprae. The validation of this technique in a robust set of samples comprising the different clinical forms of leprosy is still necessary...
November 24, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27828620/prevalence-of-american-trypanosomiasis-and-leishmaniases-in-domestic-dogs-in-a-rural-area-of-the-municipality-of-s%C3%A3-o-jo%C3%A3-o-do-piau%C3%A3-piau%C3%A3-state-brazil
#15
Taliha Dias Perez, Fabiano Borges Figueiredo, Artur Augusto Mendes Velho Junior, Valmir Laurentino Silva, Maria de Fátima Madeira, Reginaldo Peçanha Brazil, José Rodrigues Coura
Chagas disease and the leishmaniases are endemic zoonoses of great importance to public health in the state of Piauí, Brazil. The domestic dog (Canis familiaris) is a major reservoir, host of Trypanosoma cruzi and Leishmania spp. in both urban and rural areas, playing an important role in the transmission of these parasites. The present study evaluated the prevalence of both infectious diseases in dogs of a rural area in the municipality of São João do Piauí, Piauí State. One hundred twenty-nine blood samples were collected for serological assessment: for the leishmaniases, 49 (38%) animals tested positive by the Dual-Path Platform technology (DPP), nine (6%) by the Enzyme-linked Immunosorbent Assay (ELISA), and 19 (14...
November 3, 2016: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/27815426/gata1-deficient-dendritic-cells-display-impaired-ccl21-dependent-migration-toward-lymph-nodes-due-to-reduced-levels-of-polysialic-acid
#16
Maaike R Scheenstra, Iris M De Cuyper, Filipe Branco-Madeira, Pieter de Bleser, Mirjam Kool, Marjolein Meinders, Mark Hoogenboezem, Erik Mul, Monika C Wolkers, Fiamma Salerno, Benjamin Nota, Yvan Saeys, Sjoerd Klarenbeek, Wilfred F J van IJcken, Hamida Hammad, Sjaak Philipsen, Timo K van den Berg, Taco W Kuijpers, Bart N Lambrecht, Laura Gutiérrez
Dendritic cells (DCs) play a pivotal role in the regulation of the immune response. DC development and activation is finely orchestrated through transcriptional programs. GATA1 transcription factor is required for murine DC development, and data suggest that it might be involved in the fine-tuning of the life span and function of activated DCs. We generated DC-specific Gata1 knockout mice (Gata1-KO(DC)), which presented a 20% reduction of splenic DCs, partially explained by enhanced apoptosis. RNA sequencing analysis revealed a number of deregulated genes involved in cell survival, migration, and function...
November 4, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27815121/discovery-of-benzofuran-propanoic-acid-gpr120-agonists-from-uhts-hit-to-mechanism-based-pharmacodynamic-effects
#17
Matthew Lombardo, Kate Bender, Clare London, Melissa Kirkland, Joel Mane, Michele Pachanski, Wayne Geissler, John Cummings, Bahanu Habulihaz, Taro E Akiyama, Jerry Di Salvo, Maria Madeira, Joanna Pols, Mary Ann Powles, Michael F Finley, Eric Johnson, Thomas Roussel, Victor N Uebele, Alejandro Crespo, Dennis Leung, Candice Alleyne, Dorina Trusca, Ying Lei, Andrew D Howard, Feroze Ujjainwalla, James R Tata, Christopher J Sinz
The transformation of an aryloxybutanoic acid ultra high-throughput screening (uHTS) hit into a potent and selective series of G-protein coupled receptor 120 (GPR120) agonists is reported. uHTS hit 1 demonstrated an excellent rodent pharmacokinetic profile and selectivity over the related fatty acid receptor GPR40, but only modest GPR120 potency. Optimization of the "left-hand" aryl group led to compound 6, which demonstrated a GPR120 mechanism-based pharmacodynamic effect in a mouse oral glucose tolerance test (oGTT)...
October 24, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27809976/feeding-horses-with-industrially-manufactured-pellets-with-fungal-spores-to-promote-nematode-integrated-control
#18
José Ángel Hernández, Fabián Leonardo Arroyo, José Suárez, Cristiana Filipa Cazapal-Monteiro, Ángel Romasanta, María Eugenia López-Arellano, José Pedreira, Luis Manuel Madeira de Carvalho, Rita Sánchez-Andrade, María Sol Arias, Pedro Mendoza de Gives, Adolfo Paz-Silva
The usefulness of pellets industrially manufactured with spores of parasiticide fungi as a contribution to integrated nematode control was assessed in grazing horses throughout sixteen months. Two groups of 7 Pura Raza Galega autochthonous horses (G-T and G-P) were dewormed pour-on (1mg Ivermectin/kg bw) at the beginning of the trial, and other group (G-C) remained untreated. The G-P was provided daily with commercial pellets to which was added a mixture of fungal spores during the industrial manufacturing (2×10(6) spores of Mucor circinelloides and same dose of Duddingtonia flagrans/kg), and G-T and G-C received pellets without spores...
October 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27806089/high-species-richness-of-scinax-treefrogs-hylidae-in-a-threatened-amazonian-landscape-revealed-by-an-integrative-approach
#19
Miquéias Ferrão, Olavo Colatreli, Rafael de Fraga, Igor L Kaefer, Jiří Moravec, Albertina P Lima
Rising habitat loss is one of the main drivers of the global amphibian decline. Nevertheless, knowledge of amphibian diversity needed for effective habitat protection is still highly inadequate in remote tropical regions, the greater part of the Amazonia. In this study we integrated molecular, morphological and bioacoustic evidence to evaluate the species richness of the treefrogs genus Scinax over a 1000 km transect across rainforest of the Purus-Madeira interfluve, and along the east bank of the upper Madeira river, Brazilian Amazonia...
2016: PloS One
https://www.readbyqxmd.com/read/27803823/massive-bleeding-as-the-first-clinical-manifestation-of-metastatic-prostate-cancer-due-to-disseminated-intravascular-coagulation-with-enhanced-fibrinolysis
#20
Mónica Palma Anselmo, Gustavo Nobre de Jesus, João Madeira Lopes, Rui M M Victorino, João Meneses Santos
Disseminated intravascular coagulation (DIC) is the most frequent coagulation disorder associated with metastatic prostate adenocarcinoma. However, DIC with enhanced fibrinolysis as an initial presentation of prostate cancer is extremely rare. The appropriate treatment to control bleeding in these situations is challenging, controversial, and based on isolated case reports in the literature. A 66-year-old male presented at the emergency department with acute severe spontaneous ecchymoses localized to the limbs, laterocervical hematoma, and hemothorax...
2016: Case Reports in Hematology
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