keyword
https://read.qxmd.com/read/37553735/institutionalizing-evidence-informed-policy-making-in-the-postpandemic-era
#21
JOURNAL ARTICLE
Mehrnaz Kheirandish, Tanja Kuchenmuller, Ludovic Reveiz, Marge Reinap, Joseph Okeibunor, John Reeder, Arash Rashidian
No abstract text is available yet for this article.
July 31, 2023: Eastern Mediterranean Health Journal
https://read.qxmd.com/read/37511654/telemedicine-and-its-application-in-cystic-fibrosis
#22
REVIEW
Valentina Fainardi, Gaia Capoferri, Marco Tornesello, Giovanna Pisi, Susanna Esposito
The care of cystic fibrosis (CF) traditionally consists of regular visits to the clinic where a multidisciplinary team can visit the patient, adjust treatments and monitor the disease. During the COVID-19 pandemic when access to hospitals and medical environments was very limited, the role of telemedicine was crucial to keep in touch with patients with chronic diseases such as CF. Increasing evidence demonstrates that electronic health can successfully support healthcare professionals in the management of people with CF...
June 25, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37490393/baseline-mutations-and-ctdna-dynamics-as-prognostic-and-predictive-factors-in-er-positive-her2-negative-metastatic-breast-cancer-patients
#23
JOURNAL ARTICLE
Javier Pascual, Miguel Gil-Gil, Paula Proszek, Christoph Zielinski, Alistair Reay, Manuel Ruiz-Borrego, Rosalind Cutts, Eva M Ciruelos Gil, Andrew Feber, Montserrat Muñoz-Mateu, Claire Swift, Begoña Bermejo, Jesus Herranz, Mireia Margeli Vila, Antonio Antón, Zsuzsanna Kahan, Tibor Csöszi, Yuan Liu, Daniel Fernandez Garcia, Isaac Garcia-Murillas, Michael Hubank, Nicholas C Turner, Miguel Martín
PURPOSE: Prognostic and predictive biomarkers to CDK4/6 inhibitors are lacking. Circulating tumour DNA (ctDNA) can be used to profile these patients and dynamic changes in ctDNA could be an early predictor of treatment efficacy. Here, we conducted plasma ctDNA profiling in patients from the PEARL trial comparing palbociclib+fulvestrant versus capecitabine to investigate associations between baseline genomic landscape and on-treatment ctDNA dynamics with treatment efficacy. EXPERIMENTAL DESIGN: Correlative blood samples were collected at baseline (C1D1) and prior to treatment (C1D15)...
July 25, 2023: Clinical Cancer Research
https://read.qxmd.com/read/37444047/companion-animal-fostering-as-health-promotion-a-literature-review
#24
REVIEW
Christine Roseveare, Mary Breheny, Juliana Mansvelt, Linda Murray, Marg Wilkie, M Carolyn Gates
There is growing interest in the health-promoting potential of human-companion animal relationships from a broad public health perspective while acknowledging barriers to ownership, particularly for older adults. Companion animal fostering is an alternative to pet ownership that aligns with the Ottawa Charter health promotion principle that caring for others in everyday settings promotes health. This narrative review of the literature on companion animal fostering draws on Te Whare Tapa Whā (the four-sided house), an indigenous model of health that is influential in Aotearoa/New Zealand, and the Ottawa Charter...
June 21, 2023: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/37397425/challenging-the-us-supreme-court-s-majority-ruling-on-roe-v-wade-at-the-international-human-rights-level
#25
JOURNAL ARTICLE
Marge Berer
This paper proposes that US human rights experts and abortion rights advocates challenge the striking down of Roe v. Wade in June 2022 by the majority of US Supreme Court justices because of the multiple human rights violations it has engendered. The paper has three parts. The first part summarizes the compelling response of the three dissenting Supreme Court justices to the majority ruling, which spells out those violations in detail. The second part offers a history of cases of violations of human rights related to abortion in other countries that have been heard and adjudicated by a range of human rights bodies in the last 20 years, and their outcomes...
June 2023: Health and Human Rights
https://read.qxmd.com/read/37370679/pre-and-post-neoadjuvant-clinicopathological-parameters-can-help-in-the-prognosis-and-the-prediction-of-response-in-her2-and-triple-negative-breast-cancer
#26
JOURNAL ARTICLE
Laura Pons, Laura Hernández, Aintzane Urbizu, Paula Osorio, Paula Rodríguez-Martínez, Eva Castella, Ana Muñoz, Carolina Sanz, Laura Arnaldo, Eudald Felip, Vanesa Quiroga, Gustavo Tapia, Mireia Margelí, Pedro Luis Fernandez
Neoadjuvant treatment (NAT) is one of the most widely used options for HER2+ and triple negative (TN) early breast cancer (BC). Since around half of the patients treated with NAT do not achieve a pathologically complete response (pCR), biomarkers to predict resistance are urgently needed. The correlation of clinicopathological factors with pCR was studied in 150 patients (HER2 = 81; TN = 69) and pre- and post-NAT differences in tumour biomarkers were compared. Low estrogen receptor (ER) expression, high tumour-infiltrating lymphocytes (TILs) and low cT-stage were associated with pCR in HER2+ tumours ( p = 0...
June 6, 2023: Cancers
https://read.qxmd.com/read/37363809/governmentality-versus-community-the-impact-of-the-covid-lockdowns
#27
JOURNAL ARTICLE
Claire Wallace, Lucia Mytna-Kurekova, Margarita Leon, Jacqueline O'Reilly, Constantin Blome, Margarita Bussi, Becky Faith, Mark Finney, Janine Leschke, Chiara Ruffa, Emma Russell, Mi AhSchøyen, Matthias Thurer, Marge Unt, Rachel Verdin
The COVID lockdowns were characterised by new forms of governmentality as lives were disrupted and controlled through the vertical transmission of biopolitics by the state. The paper considers how this was experienced by academics in 11 different countries through analysis of diaries written during the first lockdown. The paper asks if communities can offer an alternative to governmentality by looking at three levels: the national, the neighbourhood and the personal. Whilst at a national level the idea of community was instrumentalised to encourage compliance to extraordinary measures, at the local level community compassion through helping neighbours encouraged horizontal connections that could offer a "space" within the dominant logic of governmentality...
May 9, 2023: Int J Community Wellbeing
https://read.qxmd.com/read/37273149/correction-to-seom-geicam-solti-clinical-guidelines-in-advanced-breast-cancer-2022
#28
Jose Angel Garcia-Saenz, Isabel Blancas, Isabel Echavarria, Carmen Hinojo, Mireia Margeli, Fernando Moreno, Sonia Pernas, Teresa Ramon Y Cajal, Nuria Ribelles, Meritxell Bellet
No abstract text is available yet for this article.
June 5, 2023: Clinical & Translational Oncology
https://read.qxmd.com/read/37238320/serum-ykl-40-as-a-potential-biomarker-for-sepsis-in-term-neonates-a-pilot-study
#29
JOURNAL ARTICLE
Evangelia Steletou, Dimitra Metallinou, Alexandra Margeli, Theodoros Giannouchos, Athanasios Michos, Christina Kanaka-Gantenbein, Ioannis Papassotiriou, Tania Siahanidou
Although YKL-40 is a promising diagnostic biomarker of sepsis in adults, its value in neonatal sepsis is not known. The study objectives included assessing the levels and diagnostic value of serum YKL-40 in term neonates with sepsis and comparing YKL-40 with other commonly used inflammatory biomarkers. In this pilot case-control study, 45 term neonates (30 septic and 15 non-septic, as controls), 4 to 28 days old, were prospectively studied. The International Pediatric Sepsis Consensus Conference criteria were applied to diagnose sepsis...
April 25, 2023: Children
https://read.qxmd.com/read/37211044/patritumab-deruxtecan-in-untreated-hormone-receptor-positive-her2-negative%C3%A2-early-breast-cancer-final-results-from-part-a-of-the-window-of-opportunity-solti-tot-her3-pre-operative-study
#30
JOURNAL ARTICLE
M Oliveira, C Falato, J M Cejalvo, M Margelí Vila, P Tolosa, F J Salvador-Bofill, J Cruz, M Arumi, A M Luna, J A Guerra, M Vidal, O Martínez-Sáez, L Paré, B González-Farré, E Sanfeliu, E Ciruelos, M Espinosa-Bravo, S Pernas, Y Izarzugaza, S Esker, P-D Fan, P Parul, A Santhanagopal, D Sellami, G Villacampa, J M Ferrero-Cafiero, T Pascual, A Prat
BACKGROUND: Patritumab deruxtecan (HER3-DXd) is a human epidermal growth factor receptor 3 (HER3)-directed antibody-drug conjugate composed of a fully human anti-HER3 monoclonal antibody (patritumab) covalently linked to a topoisomerase I inhibitor payload via a stable, tumor-selective, tetrapeptide-based cleavable linker. TOT-HER3 is a window-of-opportunity study designed to assess the biological activity, measured by CelTIL score [= -0.8 × tumor cellularity (in %)  +  1...
August 2023: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://read.qxmd.com/read/37188177/hope-solti-1903-breast-cancer-study-real-world-patient-centric-clinical-practice-study-to-assess-the-impact-of-genomic-data-on-next-treatment-decision-choice-in-patients-with-locally-advanced-or-metastatic-breast-cancer
#31
JOURNAL ARTICLE
Rubén Olivera-Salguero, Elia Seguí, Juan Miguel Cejalvo, Mafalda Oliveira, Pablo Tolosa, Maria Vidal, Marcos Malumbres, Joaquín Gavilá, Cristina Saura, Sonia Pernas, Rafael López, Mireia Margelí, Judith Balmaña, Montserrat Muñoz, Isabel Blancas, Valentina Boni, Eva Ciruelos, Elena Galve, Antonia Perelló, Rodrigo Sánchez-Bayona, Susana de la Cruz, Miguel de la Hoya, Patricia Galván, Esther Sanfeliu, Blanca Gonzalez-Farre, Valeria Sirenko, Aura Blanch-Torras, Jordi Canes, Helena Masanas, Rosa Olmos, Margarita Forns, Aleix Prat, Ana Casas, Tomás Pascual
BACKGROUND: Metastatic breast cancer (mBC) causes nearly all BC-related deaths. Next-generation sequencing (NGS) technologies allow for the application of personalized medicine using targeted therapies that could improve patients' outcomes. However, NGS is not routinely used in the clinical practice and its cost induces access-inequity among patients. We hypothesized that promoting active patient participation in the management of their disease offering access to NGS testing and to the subsequent medical interpretation and recommendations provided by a multidisciplinary molecular advisory board (MAB) could contribute to progressively overcome this challenge...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37183272/pre-operative-neoadjuvant-vinblastine-prednisolone-in-canine-mast-cell-tumours-a-single-centre-retrospective-cohort-study
#32
JOURNAL ARTICLE
Małgorzata Ossowska, Jose Alvarez Picornell, Riccardo Finotello, Isabel Amores-Fuster, Jean-Benoit Tanis
Neoadjuvant chemotherapy can be used in canine mast cell tumours (MCTs) to optimise surgical margins or to enable marginal excision in challenging locations. The objective of this study was to describe the outcome of dogs with cutaneous and subcutaneous MCTs treated with neoadjuvant vinblastine-prednisolone (NA-VP). Records of treatment-naïve dogs with cutaneous/subcutaneous MCT that received NA-VP were reviewed including signalment, indication for NA-VP, staging results, clinical response, surgical data and histopathology reports...
September 2023: Veterinary and Comparative Oncology
https://read.qxmd.com/read/37174877/effect-of-physiotherapy-treatment-with-immersive-virtual-reality-in-subjects-with-stroke-a-protocol-for-a-randomized-controlled-trial
#33
JOURNAL ARTICLE
Aitor Garay-Sánchez, Yolanda Marcén-Román, Mercedes Ferrando-Margelí, M Ángeles Franco-Sierra, Carmen Suarez-Serrano
BACKGROUND: Many stroke survivors suffer from sensorimotor deficits, especially balance impairments. The purpose of this trial is to investigate whether the designed Immersive Virtual Reality training program is better in the short term (15 sessions) and in the medium term (30 sessions) than physiotherapy training with Bayouk, Boucher and Leroux exercises, with respect to static balance in sitting and standing, dynamic balance and quality of life in patients with balance impairment in stroke survivors...
May 5, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/37148499/seom-geicam-solti-clinical-guidelines-in-advanced-breast-cancer-2022
#34
JOURNAL ARTICLE
Jose Angel Garcia-Saenz, Isabel Blancas, Isabel Echavarria, Carmen Hinojo, Mireia Margeli, Fernando Moreno, Sonia Pernas, Teresa Ramon Y Cajal, Nuria Ribelles, Meritxell Bellet
Advanced breast cancer represents a challenge for patients and for physicians due its dynamic genomic changes yielding to a resistance to treatments. The main goal is to improve quality of live and survival of the patients through the most appropriate subsequent therapies based on the knowledge of the natural history of the disease. In these guidelines, we summarize current evidence and available therapies for the medical management of advanced breast cancer.
May 6, 2023: Clinical & Translational Oncology
https://read.qxmd.com/read/37118769/association-between-maternal-marginalization-and-infants-born-with-congenital-heart-disease-in-ontario-canada
#35
JOURNAL ARTICLE
Qun Miao, Sandra Dunn, Shi Wu Wen, Jane Lougheed, Phoebe Yang, Michael Davies, Carolina Lavin Venegas, Mark Walker
BACKGROUND: This study aims to evaluate the impact of socioeconomic status (SES) on the risk of congenital heart disease (CHD) since previous studies have yielded inconsistent results. METHODS: We conducted a population-based retrospective cohort study, including all singleton live and still births in Ontario hospitals from April 1, 2012, to March 31, 2018. We used linked records from the Better Outcomes Registry & Network Information System, the Canadian Institute for Health Information databases, and the Ontario Marginalization Index (ON_Marg)...
April 28, 2023: BMC Public Health
https://read.qxmd.com/read/37112128/benchmarking-dataset-of-signals-from-a-commercial-mems-magnetic-angular-rate-gravity-marg-sensor-manipulated-in-regions-with-and-without-geomagnetic-distortion
#36
JOURNAL ARTICLE
Pontakorn Sonchan, Neeranut Ratchatanantakit, Nonnarit O-Larnnithipong, Malek Adjouadi, Armando Barreto
In this paper, we present the FIU MARG Dataset (FIUMARGDB) of signals from the tri-axial accelerometer, gyroscope, and magnetometer contained in a low-cost miniature magnetic-angular rate-gravity (MARG) sensor module (also known as magnetic inertial measurement unit, MIMU) for the evaluation of MARG orientation estimation algorithms. The dataset contains 30 files resulting from different volunteer subjects executing manipulations of the MARG in areas with and without magnetic distortion. Each file also contains reference ("ground truth") MARG orientations (as quaternions) determined by an optical motion capture system during the recording of the MARG signals...
April 7, 2023: Sensors
https://read.qxmd.com/read/37050684/multi-phase-fusion-for-pedestrian-localization-using-mass-market-gnss-and-mems-sensors
#37
JOURNAL ARTICLE
Qiang Liu, Rendong Ying, Zhendong Dai, Yuze Wang, Jiuchao Qian, Peilin Liu
Precise pedestrian positioning based on smartphone-grade sensors has been a research hotspot for several years. Due to the poor performance of the mass-market Micro-Electro-Mechanical Systems (MEMS) Magnetic, Angular Rate, and Gravity (MARG) sensors, the standalone pedestrian dead reckoning (PDR) module cannot avoid long-time heading drift, which leads to the failure of the entire positioning system. In outdoor scenes, the Global Navigation Satellite System (GNSS) is one of the most popular positioning systems, and smartphone users can use it to acquire absolute coordinates...
March 30, 2023: Sensors
https://read.qxmd.com/read/37045655/-fascio-cutaneous-exeresis-of-a-dermatofibrosarcoma-of-darier-ferrand-of-the-right-flank
#38
JOURNAL ARTICLE
Saïd Haddadi, Makram El Mammeri, Yacine Bouache, Rabah Ourdane, Rezki Touati
INTRODUCTION: Darrier-Ferrand dermatofibrosarcoma (DFSC) is the most common cutaneous sarcoma. It generally affects subjects with an average age of 40 years, without gender or race predominance. It is a tumour characterised by a slow evolution and local aggressiveness. The reasons for consultation are pain, pruritus or rapidly progressive evolution. There are no specific imaging studies for this tumour. The diagnosis of certainty is based on immunohistochemistry with positive CD34 labelling...
April 10, 2023: Annales de Chirurgie Plastique et Esthétique
https://read.qxmd.com/read/37015416/accurate-cobb-angle-estimation-on-scoliosis-x-ray-images-via-deeply-coupled-two-stage-network-with-differentiable-cropping-and-random-perturbation
#39
JOURNAL ARTICLE
Yuanhuai Liang, Jinxin Lv, Dun Li, Xin Yang, Zhiwei Wang, Qiang Li
Automated Cobb angle estimation on X-ray images is crucial to scoliosis diagnosis. The existing efforts are typically two extremes, which either laboriously detect the raw vertebral landmarks or directly regress Cobb angles from the entire image. In this paper, we propose a novel two-stage end-to-end method as a balanced solution, to avoid vulnerability to false landmarks, and to preserve flexibility in clinical usages. Concretely, we cascade two stages sequentially for detecting vertebrae and then regressing their bending directions instead of raw landmarks...
December 16, 2022: IEEE Journal of Biomedical and Health Informatics
https://read.qxmd.com/read/36991992/neurosuitup-system-architecture-and-validation-of-a-motor-rehabilitation-wearable-robotics-and-serious-game-platform
#40
JOURNAL ARTICLE
Konstantinos Mitsopoulos, Vasiliki Fiska, Konstantinos Tagaras, Athanasios Papias, Panagiotis Antoniou, Konstantinos Nizamis, Konstantinos Kasimis, Paschalina-Danai Sarra, Diamanto Mylopoulou, Theodore Savvidis, Apostolos Praftsiotis, Athanasios Arvanitidis, George Lyssas, Konstantinos Chasapis, Alexandros Moraitopoulos, Alexander Astaras, Panagiotis D Bamidis, Alkinoos Athanasiou
BACKGROUND: This article presents the system architecture and validation of the NeuroSuitUp body-machine interface (BMI). The platform consists of wearable robotics jacket and gloves in combination with a serious game application for self-paced neurorehabilitation in spinal cord injury and chronic stroke. METHODS: The wearable robotics implement a sensor layer, to approximate kinematic chain segment orientation, and an actuation layer. Sensors consist of commercial magnetic, angular rate and gravity (MARG), surface electromyography (sEMG), and flex sensors, while actuation is achieved through electrical muscle stimulation (EMS) and pneumatic actuators...
March 20, 2023: Sensors
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