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https://www.readbyqxmd.com/read/29311080/mycobacterium-abscessus-smooth-and-rough-morpohotypes-form-antimicrobial-tolerant-biofilm-phenotypes-but-are-killed-by-acetic-acid
#1
Gillian Clary, Smitha Sasindran, Nathan Nesbitt, Laurel Mason, Sara Cole, Abul Azad, Karen McCoy, Larry S Schlesinger, Luanne Hall-Stoodley
Mycobacterium abscessus has emerged as an important pathogen in people with chronic inflammatory lung diseases such as cystic fibrosis, and recent reports suggest that it may be transmissible by fomites. M. abscessus exhibits two major colony morphology variants: a smooth morphotype (MaSm ) and a rough morphotype (MaRg ). Biofilm formation, prolonged intracellular survival, and colony variant diversity can each contribute to the persistence of M. abscessus and other bacterial pathogens in chronic pulmonary diseases...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29303803/postoperative-eras-interventions-have-the-greatest-impact-on-optimal-recovery-experience-with-implementation-of-eras-across-multiple-hospitals
#2
Mary-Anne Aarts, Ori D Rotstein, Emily A Pearsall, J Charles Victor, Allan Okrainec, Marg McKenzie, Stuart A McCluskey, Lesley Gotlib Conn, Robin S McLeod
BACKGROUND: Enhanced recovery after surgery (ERAS) programs incorporate evidence-based practices to minimize perioperative stress, gut dysfunction, and promote early recovery. However, it is unknown which components have the greatest impact. OBJECTIVE: This study aims to determine which components of ERAS programs have the largest impact on recovery for patients undergoing colorectal surgery. METHODS: An iERAS program was implemented in 15 academic hospitals...
January 4, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29299141/optimization-of-the-margin-expanded-from-the-clinical-to-the-planned-target-volume-during-intensity-modulated-radiotherapy-for-nasopharyngeal-carcinoma
#3
Wang Fangzheng, Sun Quanquan, Jiang Chuner, Ye Zhimin, Yang Shuangyan, Yu Huanhuan, Shi Jianfang, Masoto Sakamoto, Qin Weifeng, Fu Zhenfu, Jiang Yangming, Wang Yuezhen
During the radiotherapy process, the emergence of set-up errors is nearly inevitable. Because set-up errors were not detected and corrected daily, planned target volumes were formed by expanding the clinical target volume according to each unit's experience. We optimized the margins of clinical and planned target volumes during administration of intensity-modulated radiotherapy for nasopharyngeal carcinoma. A total of 72 patients newly diagnosed with non-metastatic nasopharyngeal carcinoma and treated with Tomotherapy were prospectively enrolled in the study...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288632/association-of-vascular-indices-with-novel-circulating-biomarkers-as-prognostic-factors-for-cardiovascular-complications-in-patients-with-type-2-diabetes-mellitus
#4
Katerina K Naka, Katerina Papathanassiou, Aris Bechlioulis, Konstantinos Pappas, Stelios Tigas, Dimitrios Makriyiannis, Sophia Antoniou, Nikolaos Kazakos, Alexandra Margeli, Ioannis Papassotiriou, Agathocles Tsatsoulis, Lampros K Michalis
BACKGROUND: The pathophysiology of atherosclerosis in type 2 diabetes mellitus (T2DM) is multifactorial. The association of vascular indices with circulating biomarkers of inflammation and insulin resistance and their role in the long-term cardiovascular prognosis in T2DM patients were currently investigated. PATIENTS AND METHODS: Patients with T2DM and poor glycemic control without known cardiovascular diseases (n=119) at baseline were enrolled and followed for about 9years...
December 27, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29242083/medical-abortion-pills-have-the-potential-to-change-everything-about-abortion-but%C3%A2
#5
EDITORIAL
Marge Berer, Lesley Hoggart
No abstract text is available yet for this article.
December 11, 2017: Contraception
https://www.readbyqxmd.com/read/29171132/structured-education-to-improve-primary-care-management-of-headache-how-long-do-the-benefits-last-a-follow-up-observational-study
#6
Mark Braschinsky, Sulev Haldre, Mart Kals, Marge Arge, Bruno Saar, Maris Niibek, Zaza Katsarava, Timothy J Steiner
BACKGROUND: Our earlier study showed that structured education of general practitioners (GPs) improved their practice in headache management. Here we assess duration of this effect. METHODS: In a follow-up observational study in Southern Estonia, subjects were the same six GPs as previously, managing patients presenting with headache as the main complaint. Data reflecting their practice were collected prospectively during a 1-year period commencing 2 years after the educational intervention...
November 24, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29144599/assessing-social-values-for-california-s-efforts-to-reduce-the-overuse-of-unnecessary-medical-care
#7
Susan L Perez, Desiree Backman, Marge Ginsburg
BACKGROUND: A partnership of large health-care purchasers created a workgroup to reduce the overuse of harmful and wasteful medical care in California. OBJECTIVE: Employ a civic engagement process to identify the social values important to the public in considering different strategies to reduce overuse. INTERVENTION: Use of deliberation techniques for 3 case examples that explore possible strategies: physician oversight, physician compensation, increased patient cost-sharing or taking no definitive action...
November 16, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29142045/a-rapid-assay-for-detection-of-the-epidemiologically-important-central-asian-russian-strain-of-the-mycobacterium-tuberculosis-beijing-genotype
#8
Igor Mokrousov, Ekaterina Chernyaeva, Anna Vyazovaya, Yuriy Skiba, Natalia Solovieva, Violeta Valcheva, Klavdia Levina, Natalya Malakhova, Wei-Wei Jiao, Lia Lima Gomes, Philip N Suffys, Marge Kütt, Nagima Aitkhozhina, A-Dong Shen, Olga Narvskaya, Viacheslav Zhuravlev
Mycobacterium tuberculosis isolates of the Beijing 94-32-cluster (also named "Central Asian/Russian Beijing strain") constitute an important component of the population structure of the pathogen in the Former Soviet Union (FSU) countries (1-4).….
November 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29119620/identification-of-oestrogen-progesterone-receptor-and-human-epidermal-growth-factor-receptor-2-expression-in-mediastinal-metastases-of-breast-cancer-obtained-by-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#9
P Serra, J Sanz-Santos, E Castellà, B Cirauqui, F Andreo, M Llatjós, M Avila, M Margelí, L Serrano, C Centeno, V Quiroga, M Torky, J Ruiz-Manzano
BACKGROUND: In breast cancer patients, the expression statuses of oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are crucial in the choice of treatment. Receptor expression in metastatic lesions can differ from the primary tumour. The aim of our study was to analyse the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to obtain samples allowing the identification of ER, PR and HER2 expression in patients with mediastinal metastases of breast cancer...
November 9, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29093447/e-cadherin-integrates-mechanotransduction-and-egfr-signaling-to-control-junctional-tissue-polarization-and-tight-junction-positioning
#10
Matthias Rübsam, Aaron F Mertz, Akiharu Kubo, Susanna Marg, Christian Jüngst, Gladiola Goranci-Buzhala, Astrid C Schauss, Valerie Horsley, Eric R Dufresne, Markus Moser, Wolfgang Ziegler, Masayuki Amagai, Sara A Wickström, Carien M Niessen
Generation of a barrier in multi-layered epithelia like the epidermis requires restricted positioning of functional tight junctions (TJ) to the most suprabasal viable layer. This positioning necessitates tissue-level polarization of junctions and the cytoskeleton through unknown mechanisms. Using quantitative whole-mount imaging, genetic ablation, and traction force microscopy and atomic force microscopy, we find that ubiquitously localized E-cadherin coordinates tissue polarization of tension-bearing adherens junction (AJ) and F-actin organization to allow formation of an apical TJ network only in the uppermost viable layer...
November 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/29092043/emerging-resistant-clones-of-mycobacterium-tuberculosis-in-a-spatiotemporal-context
#11
Anna Vyazovaya, Klavdia Levina, Viacheslav Zhuravlev, Piret Viiklepp, Marge Kütt, Igor Mokrousov
Objectives: We assessed the genetic structure of the Mycobacterium tuberculosis population in Estonia with a special focus on major epidemic/endemic clones and drug resistance determinants. We investigated the hypothesis of the decisive impact of massive human influx on the locally circulating genotypes. Estonia received a mass immigration from Russia during 1945-90 followed by enhanced interaction with the EU since 1991. Methods: The study sample included M. tuberculosis isolates from patients newly diagnosed with TB in 2014 in North Estonia (including the capital Tallinn)...
October 30, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28990748/cal-mediconnect-enrollment-why-are-dual-eligible-consumers-in-los-angeles-county-opting-out
#12
Kate McBride, Ana Reynoso, Tiffany Alunan, Brenda Gutierrez, Adrien Bacong, Marge Moon, Anastasia Bacigalupo, A E Benjamin, Steven P. Wallace, Kathryn G Kietzman
Los Angeles County has the state’s lowest rate of consumer enrollment in Cal MediConnect, a program that is responsible for the delivery and coordination of medical, behavioral health, and long-term services and support benefits for individuals who are dually eligible for Medicare and Medi-Cal. This policy brief examines the factors that influence consumer decisions and may contribute to low enrollment rates. Influential factors include consumer knowledge of health care options, perception of choice, and disruption of existing care...
September 1, 2017: Policy Brief
https://www.readbyqxmd.com/read/28967571/evaluation-of-the-effect-of-test-medium-on-total-cu-body-burden-of-nano-cuo-exposed-daphnia-magna-a-txrf-spectroscopy-study
#13
Marge Muna, Margit Heinlaan, Irina Blinova, Heiki Vija, Anne Kahru
Toxicity of Cu and Cu-based nanoparticles (NPs) to aquatic biota is usually mitigated in natural freshwater compared to organics-free artificial freshwater. The main aim of this study was to evaluate whether mitigated toxicity is accompanied by lower total copper body burden in the freshwater crustacean Daphnia magna and whether CuO NPs are more hazardous in this aspect than soluble Cu salts. Total copper body burden in different media (OECD202 artificial freshwater and two natural freshwaters) was measured by a relatively novel technique - total reflection X-ray fluorescence (TXRF) spectroscopy - which proved suitable for the analysis of individual juvenile daphnids...
December 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28963168/maternal-death-surveillance-and-response-a-tall-order-for-effectiveness-in-resource-poor-settings
#14
EDITORIAL
Marge Koblinsky
No abstract text is available yet for this article.
September 27, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28954065/guidelines-for-the-management-of-human-brucellosis-in-the-state-of-paran%C3%A3-brazil
#15
Felipe Francisco Tuon, Natacha Cerchiari, Juliana Clélia Cequinel, Elizabeth El Hajjar Droppa, Suzana Dal Ri Moreira, Tânia Portella Costa, Amanda de Paula Boni Navarro, Antonieta Milleo Handar, Margely Nunes de Souza
Human brucellosis is a re-emerging disease with the potential for bioterrorism. The number of cases in Brazil has increased; however, the ideal management has not been established. These guidelines are intended for use by clinicians and other health-care workers providing medical care for patients with suspected brucellosis in the State of Paraná. We included a brief description of the epidemiology, clinical presentation, diagnosis, prevention of exposure, prevention of disease by chemoprophylaxis, treatment of disease, monitoring of adverse effects during treatment, management of treatment failure and relapse cases...
July 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28916971/emergency-room-visits-and-readmissions-following-implementation-of-an-enhanced-recovery-after-surgery-ieras-program
#16
Trevor Wood, Mary-Anne Aarts, Allan Okrainec, Emily Pearsall, J Charles Victor, Marg McKenzie, Ori Rotstein, Robin S McLeod
BACKGROUND: Enhanced Recovery After Surgery (ERAS) guidelines have been widely promoted and supported largely due to several studies showing decreased post-operative complications and length of stay. The objective of this study was to review the emergency room (ER) visits and readmission rates and reasons for both in patients who were part of the Implementation of an Enhanced Recovery After Surgery (iERAS) program for colorectal surgery. METHODS: All patients having elective colorectal surgery at 15 academic hospitals were enrolled in the iERAS program...
September 15, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28899298/book-review-understanding-the-work-of-nurse-theorists-a-creative-beginning-kathleen-sitzman-and-lisa-wright-eichelberger-2017-burlington-ma-jones-bartlett
#17
https://www.readbyqxmd.com/read/28892861/assessment-of-the-hazard-of-nine-doped-lanthanides-based-ceramic-oxides-to-four-aquatic-species
#18
Irina Blinova, Heiki Vija, Aljona Lukjanova, Marge Muna, Guttorm Syvertsen-Wiig, Anne Kahru
The risk of environmental pollution with rare earth oxides rises in line with increasing application of these compounds in different sectors. However, data on potential environmental hazard of lanthanides is scarce and concerns mostly Ce and Gd. In this work, the aquatic toxicity of eight doped lanthanide-based ceramic oxides (Ce0.9Gd0.1O2, LaFeO3, Gd0.97CoO3, LaCoO3, (La0.5Sr0.5)0.99MnO3, Ce0.8Pr0.2O2, (La0.6Sr0.4)0.95CoO3, LaNiO4) and one non-doped oxide (CeO2) with primary size from 23 to 590nm were evaluated in four short-term laboratory assays with freshwater crustaceans and duckweeds...
January 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28876211/human-papillomavirus-related-cancer-surveillance-prevention-and-screening-among-transgender-men-and-women-neglected-populations-at-high-risk
#19
Brandon Brown, Tonia Poteat, Logan Marg, Jerome T Galea
Researchers and healthcare surveillance systems must clearly disaggregate data for transgender men and women from data for cisgender men and women to identify population-level health disparities and give every person an opportunity for cancer prevention. The limited human papillomavirus (HPV) vaccine recommendations for transgender men and women may be due to the scant literature on cancer prevalence coupled with poor understanding of HPV risks for these populations. Comprehensive cancer screening and prevention initiatives centered on relevant anatomy and sexual risk behaviors that are inclusive of transgender men and women are needed...
September 6, 2017: LGBT Health
https://www.readbyqxmd.com/read/28838282/a-retrospective-analysis-comparing-apceden-%C3%A2-dendritic-cell-immunotherapy-with-best-supportive-care-in-refractory-cancer
#20
Chaitanya Kumar, Sakshi Kohli, Srikanth Chiliveru, Poonamalle Parthasarathy Bapsy, Minish Jain, Venkata Sathya Suresh Attili, Jagan Mohan, Ashok K Vaid, Bandana Sharan
AIM: A retrospective survival benefit analysis of APCEDEN(®), APAC BIOTECH Pvt Ltd 69, Jacranda Marg, DLF PHASE II, Gurugram, Haryana, India, an autologous dendritic cell-based product for management of refractory solid malignancies, was performed in comparison with a control group. METHODS: Subjects (retrospective data) whose survival data, geographical region, age, gender, ECOG performance status and stage of disease that could be matched with the treatment group were considered for analysis...
August 25, 2017: Immunotherapy
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