keyword
https://read.qxmd.com/read/38435422/a-novel-myb-paip1-oncogenic-fusion-in-pediatric-blastic-plasmacytoid-dendritic-cell-neoplasm-bpdcn-is-dependent-on-bcl2-expression-and-is-sensitive-to-venetoclax
#1
JOURNAL ARTICLE
Hansen J Kosasih, Gerry Healey, Margs S Brennan, Stefan Bjelosevic, Teresa Sadras, Fatimah B Jalud, Tasnia Ibnat, Ashley P Ng, Chelsea Mayoh, Jie Mao, Gabor Tax, Louise E A Ludlow, Ricky W Johnstone, Marco J Herold, Seong L Khaw, Charles E de Bock, Paul G Ekert
No abstract text is available yet for this article.
February 2024: HemaSphere
https://read.qxmd.com/read/38394067/comparing-pronunciation-challenges-in-south-korean-preschoolers-with-unilateral-single-sided-deafness-due-to-cochlear-nerve-deficiency-to-a-norm-referenced-standard
#2
JOURNAL ARTICLE
Goun Choe, Jong Woo Lim, Hyun Jung Lee, Seung Hyun Kim, Marge Carandang, Bong Jik Kim, Byung Yoon Choi
This study aimed to compare the development of pronunciation in South Korean preschoolers with unilateral cochlear nerve deficiency (CND) to that of age-matched preschoolers with normal hearing, a topic that has not been explored previously. In a retrospective analysis, 25 preschoolers with unilateral CND who had undergone a speech evaluation battery, including a pronunciation and vocabulary test, were enrolled. Utilizing the Urimal Test of Articulation and Phonation and customized language ability tests, pronunciation and vocabulary were assessed...
2024: PloS One
https://read.qxmd.com/read/38376020/plasma-antioxidant-potential-measured-by-total-radical-trapping-antioxidant-parameter-in-a-cohort-of-multiple-sclerosis-patients
#3
JOURNAL ARTICLE
Marge Kartau, Joonas Kartau, Marjatta Pohja, Auli Verkkoniemi-Ahola
BACKGROUND: Oxidative injury has been implicated as a mediator of demyelination, axonal damage, and neurodegeneration in multiple sclerosis (MS). There is a high demand for oxidative injury biomarkers. The aim of the study was to evaluate MS patients' plasma antioxidant potential using the total radical trapping parameter (TRAP) assay and examine its usefulness as an MS disease biomarker. METHODS: A total number of 112 MS patients underwent an analysis of TRAP. In addition, plasma uric acid (UA) levels were analyzed...
January 2024: Brain and Behavior
https://read.qxmd.com/read/38373496/-maternal-deaths-due-to-hypertensive-disorders-in-france-2016-2018
#4
JOURNAL ARTICLE
Michel Dreyfus, Agnès Rigouzzo, Marie Jonard
Between 2016 and 2018, 13 maternal deaths were due to hypertensive disorders. During this period, the maternal mortality ratio was 0.6/100 000 live births. Hypertensive disorders were responsible for 4.8 % of maternal deaths during the first year, 5.1 % up to 42 days postpartum and for 13.5 % of direct maternal mortality. Maternal deaths due to hypertensive disorders increased close to signification (p = 0.09) compared to the last triennium (MMR = 0.2/100.000). Classification of the hypertensive disorders was : 5 severe preeclampsia, 3 eclampsia, 4 HELLP syndromes et 1 undefined hypertension...
February 17, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
https://read.qxmd.com/read/38265355/the-impact-of-marginalization-on-diffuse-large-b-cell-lymphoma-overall-survival-a-retrospective-cohort-study
#5
JOURNAL ARTICLE
Sumedha Arya, Lee Mozessohn, Inna Gong, Neil Faught, Ning Liu, Simron Singh, Kelvin Chan, Matthew C Cheung
The aim of this study was to describe the impact of marginalization on DLBCL overall survival (OS) within the Canadian setting. We conducted a population-based retrospective cohort study of adult patients with newly diagnosed DLBCL in Ontario between 1 January 2005 and 31 December 2017 receiving a rituximab-containing chemotherapy regimen with curative intent followed until 1 March 2020. Our primary exposure of interest was the Ontario Marginalization Index (ON-Marg). The primary outcome was 2-year OS, accounting for patient age, sex, cancer characteristics, comorbidity burden, and rural dwelling status...
January 24, 2024: Leukemia & Lymphoma
https://read.qxmd.com/read/38230754/estonia-health-system-review
#6
JOURNAL ARTICLE
Kaija Kasekamp, Triin Habicht, Andres Võrk, Kristina Köhler, Marge Reinap, Kristiina Kahur, Heli Laarmann, Yulia Litvinova
This analysis of the Estonian health system illustrates recent developments in organization and governance, health financing, health care provision, health reforms and health system performance. In general, Estonia spends less per capita on health than the European Union average, although public expenditure has been growing steadily, with an increasing role of government budget transfers towards the social health insurance model. Despite these efforts, more than a fifth of current health expenditure comes from out-of-pocket payments, creating pressure to develop new and strengthen existing financial protection instruments...
December 2023: Health Systems in Transition
https://read.qxmd.com/read/38188174/metagenomic-assembly-is-the-main-bottleneck-in-the-identification-of-mobile-genetic-elements
#7
JOURNAL ARTICLE
Jesse J Kerkvliet, Alex Bossers, Jannigje G Kers, Rodrigo Meneses, Rob Willems, Anita C Schürch
Antimicrobial resistance genes (ARG) are commonly found on acquired mobile genetic elements (MGEs) such as plasmids or transposons. Understanding the spread of resistance genes associated with mobile elements (mARGs) across different hosts and environments requires linking ARGs to the existing mobile reservoir within bacterial communities. However, reconstructing mARGs in metagenomic data from diverse ecosystems poses computational challenges, including genome fragment reconstruction (assembly), high-throughput annotation of MGEs, and identification of their association with ARGs...
2024: PeerJ
https://read.qxmd.com/read/38110554/combined-absence-of-trp53-target-genes-zmat3-puma-and-p21-cause-a-high-incidence-of-cancer-in-mice
#8
JOURNAL ARTICLE
Margs S Brennan, Kerstin Brinkmann, Gerard Romero Sola, Geraldine Healey, Leonie Gibson, Lahiru Gangoda, Margaret A Potts, Elizabeth Lieschke, Stephen Wilcox, Andreas Strasser, Marco J Herold, Ana Janic
Transcriptional activation of target genes is essential for TP53-mediated tumour suppression, though the roles of the diverse TP53-activated target genes in tumour suppression remains poorly understood. Knockdown of ZMAT3, an RNA-binding zinc-finger protein involved in regulating alternative splicing, in haematopoietic cells by shRNA caused leukaemia only with the concomitant absence of the PUMA and p21, the critical effectors of TRP53-mediated apoptosis and cell cycle arrest respectively. We were interested to further investigate the role of ZMAT3 in tumour suppression beyond the haematopoietic system...
December 18, 2023: Cell Death and Differentiation
https://read.qxmd.com/read/38060345/where-is-your-pain-achilles-tendinopathy-pain-location-on-loading-is-different-to-palpation-imaging-and-recall-location
#9
JOURNAL ARTICLE
Ebonie K Rio, Chantel L Rabusin, Shannon E Munteanu, Sean I Docking, Marg Perrott, Jamon Couch, Myles C Murphy, Michael Girdwood
OBJECTIVE: To describe and compare pain maps reported during Achilles tendon loading exercises with recall pain location, in people with pain on palpation in their Achilles tendon and tendon pathology on imaging. DESIGN: Cross-sectional analysis of baseline RCT. METHOD: Participants were recruited from a larger Achilles tendinopathy clinical trial. Inclusion criteria were at least 2-month self-reported history of Achilles tendinopathy, midtendon palpation pain, and pathology on ultrasound tissue characterization...
January 2024: Journal of Orthopaedic and Sports Physical Therapy
https://read.qxmd.com/read/37868292/risk-factors-predicting-acute-postoperative-pain-immediately-after-minimally-invasive-inguinal-hernia-repair
#10
JOURNAL ARTICLE
Egle Kubiliute, Donatas Venskutonis, Audrius Parseliunas, Ernest Margelis, Mindaugas Kiudelis
INTRODUCTION: Acute postoperative pain remains one of the most common problems, even after laparoscopic or endoscopic hernia repair. Avoiding predictive factors for acute pain after surgery or prescribing additional analgesia for a patient who has risk factors that cannot be removed can be one of the options to reduce acute postoperative pain. However, there is a lack of clinical studies that evaluate the predictive factors of postoperative pain after transabdominal preperitoneal (TAPP) and totally extraperitoneal (TEP) surgeries...
September 2023: Videosurgery and Other Miniinvasive Techniques
https://read.qxmd.com/read/37867122/-recurrence-of-palpebral-basal-cell-carcinoma-according-to-histological-margins
#11
JOURNAL ARTICLE
M Toure, M-L Quintyn-Ranty, P Saguet, R Bouchoucha, F Mouriaux, J-C Quintyn
BACKGROUND: Basal cell carcinomas (BCCs) represent 90% of malignant tumors of the eyelids, which can be locally invasive and destructive. The observation of histological safety margins (MHS) allows for the prevention of recurrence while maintaining a fair compromise between aesthetics and functionality. However, to date, there is no consensus or national recommendations concerning the MHS to be observed according to the various histological subtypes of BCCs. METHODS: Through a retrospective analysis of patient records and corresponding excisional slides, we studied the 6-year recurrence rate of 98 patients who underwent surgery for palpebral BCC...
October 20, 2023: Journal Français D'ophtalmologie
https://read.qxmd.com/read/37854405/methods-and-tools-to-assess-implementation-of-mental-health-policies-and-plans-a-systematic-review
#12
REVIEW
Akmal Alikhan Aliev, Hana Tomaskova, Petr Winkler, Yongjie Yon, Anna Kagstrom, Zoe Guerrero, Ledia Lazeri, Marge Reinap, Cassie Redlich, Ana Maria Tijerino Inestroza, Jason Maurer
Mental health policies and plans (MHPPs) are important policy instruments and powerful tools to facilitate development of mental health systems and services across the world. We aimed to map and analyse methods and tools used to assess the extent, process and impact of implementing MHPPs. We systematically searched peer-reviewed and grey literature across seven scientific databases. We extracted and analysed the data on a) the characteristics of included studies (e.g., policy areas, region of origin, income setting) and b) the methodology and evaluation tools applied to assess the extent and process of implementation...
2023: Global Mental Health
https://read.qxmd.com/read/37817880/bioin-tacto-a-compliant-multi-modal-tactile-sensing-module-for-robotic-tasks
#13
JOURNAL ARTICLE
Thiago Eustaquio Alves de Oliveira, Vinicius Prado da Fonseca
We present the open-source design and fabrication of a compliant multimodal tactile sensing module. The sensing module design presented here enables robotic end-effectors to sense contact properties like pressure and vibration and estimate a quaternion that represents the deformation due to contact. We elaborated the module's compliant structure fabrication process to use only 3D printed molds and a vacuum chamber, making it accessible to a broad range of roboticists. The process also allows production batches of up to five modules and easy deployment to robotic hands...
December 2023: HardwareX
https://read.qxmd.com/read/37806388/screening-of-endophytic-fungi-from-antarctic-mosses-potential-production-for-l-asparaginase-free-of-glutaminase-and-urease-activity
#14
JOURNAL ARTICLE
Guilherme Afonso Kessler de Andrade, Maria Victória Magalhães de Vargas, Sara Navarrete Bohi Goulart, Bruna Mota Bernardes, Jadson D P Bezerra, Rafael Plá Matielo Lemos, Filipe de Carvalho Victoria, Margéli Pereira de Albuquerque
Studies involving endophytic fungi aim to identify organisms inhabiting extreme and relatively unexplored environments, as these fungi possess unique characteristics and uncommon biochemical pathways that enable them to produce compounds with biotechnological potential. Among various enzymes, L-Asparaginase is employed in the treatment of Acute Lymphoblastic Leukemia. In this study, we identified endophytic fungi from Sanionia uncinata and Polytrichastrum alpinum collected on King George Island in Antarctica...
October 6, 2023: Journal of Biotechnology
https://read.qxmd.com/read/37733985/two-discrete-types-of-tip-fold-over-in-cochlear-implantation-using-slim-modiolar-electrodes-influence-of-cochlear-duct-length-on-tip-fold-over
#15
JOURNAL ARTICLE
Heonjeong Oh, Yehree Kim, Seung Jae Lee, Marge Carandang, Jae-Jin Song, Byung Yoon Choi
OBJECTIVE: Precise electrode positioning is crucial for achieving optimal audiological outcomes in cochlear implantation. The slim modiolar electrode (SME), a thin, flexible, and precurved electrode, exhibits favorable modiolar proximity. However, tip fold-over can affect optimal electrode placement. Herein, we share our experiences with tip fold-over in SMEs and present an analysis of conditions that may predispose to tip fold-over. STUDY DESIGN: Retrospective medical record review...
September 20, 2023: Otology & Neurotology
https://read.qxmd.com/read/37704268/corrigendum-to-contradictions-of-hegemonic-masculinity-and-the-hopeful-potential-of-old-age-and-caring-masculinity-in-estonian-society-and-in-films-a-friend-of-mine-2011-and-tangerines-2013-journal-of-aging-studies-volume-63-2022-1-7-101034
#16
https://read.qxmd.com/read/37667113/samhd1-expression-is-a-surrogate-marker-of-immune-infiltration-and-determines-prognosis-after-neoadjuvant-chemotherapy-in-early-breast-cancer
#17
JOURNAL ARTICLE
Lucía Gutiérrez-Chamorro, Eudald Felip, Eva Castellà, Vanessa Quiroga, Ifeanyi Jude Ezeonwumelu, Laura Angelats, Anna Esteve, Laia Perez-Roca, Anna Martínez-Cardús, Pedro Luis Fernandez, Angelica Ferrando-Díez, Anna Pous, Milana Bergamino, Beatriz Cirauqui, Marga Romeo, Iris Teruel, Ricard Mesia, Bonaventura Clotet, Eva Riveira-Muñoz, Mireia Margelí, Ester Ballana
PURPOSE: The lack of validated surrogate biomarkers is still an unmet clinical need in the management of early breast cancer cases that do not achieve complete pathological response after neoadjuvant chemotherapy (NACT). Here, we describe and validate the use of SAMHD1 expression as a prognostic biomarker in residual disease in vivo and in vitro. METHODS: SAMHD1 expression was evaluated in a clinical cohort of early breast cancer patients with stage II-III treated with NACT...
September 4, 2023: Cellular Oncology (Dordrecht)
https://read.qxmd.com/read/37622610/parental-perceptions-of-social-and-emotional-well-being-of-young-children-from-australian-military-families
#18
JOURNAL ARTICLE
Marg Rogers, Amy Johnson, Yumiko Coffey, Jill Fielding, Ingrid Harrington, Navjot Bhullar
INTRODUCTION: Many Australian Defence Force (ADF) and Veteran families are affected by the stressors of Defence family life, including frequent and prolonged parental deployments, and frequent relocations. OBJECTIVE: To address a gap in information about Defence and Veteran (hereafter Defence) parents' knowledge, confidence and resources to support their young children's well-being and build their resilience. DESIGN: This study used a mixed methods design to explore Defence parent's perceptions of their young children's (aged 2-8 years) social and emotional well-being and understanding of their children's responses to unique stressors as well as their confidence in providing support...
August 25, 2023: Australian Journal of Rural Health
https://read.qxmd.com/read/37577860/biodistribution-of-recombinant-factor-ix-extended-half-life-recombinant-factor-ix-fc-fusion-protein-and-glycopegylated-recombinant-factor-ix-in-hemophilia-b-mice
#19
JOURNAL ARTICLE
Arjan van der Flier, Vu Hong, Zhan Liu, Peter Piepenhagen, Gregory Ulinski, Jennifer A Dumont, Kelly D Orcutt, Apollina Goel, Robert Peters, Joe Salas
Extended half-life recombinant FIX (rFIX) molecules have been generated to reduce the dosing burden and increase the protection of patients with hemophilia B. Clinical pharmacology studies with recombinant factor IX Fc fusion protein (rFIXFc) report a similar initial peak plasma recovery to that of rFIX, but with a larger volume of distribution. Although the pegylation of N9-GP results in a larger plasma recovery, there is a smaller volume of distribution, suggesting less extravasation of the latter drug. In this study, we set out to compare the biodistribution and tissue localization of rFIX, rFIXFc, and glycoPEGylated rFIX in a hemophilia B mouse model...
July 18, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37571484/imu-uwb-fusion-method-using-a-complementary-filter-and-a-kalman-filter-for-hybrid-upper-limb-motion-estimation
#20
JOURNAL ARTICLE
Yutong Shi, Yongbo Zhang, Zhonghan Li, Shangwu Yuan, Shihao Zhu
Motion capture systems have enormously benefited the research into human-computer interaction in the aerospace field. Given the high cost and susceptibility to lighting conditions of optical motion capture systems, as well as considering the drift in IMU sensors, this paper utilizes a fusion approach with low-cost wearable sensors for hybrid upper limb motion tracking. We propose a novel algorithm that combines the fourth-order Runge-Kutta (RK4) Madgwick complementary orientation filter and the Kalman filter for motion estimation through the data fusion of an inertial measurement unit (IMU) and an ultrawideband (UWB)...
July 26, 2023: Sensors
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