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https://www.readbyqxmd.com/read/28292617/obesity-pandemic-causes-consequences-and-solutions-but-do-we-have-the-will
#1
REVIEW
David R Meldrum, Marge A Morris, Joseph C Gambone
Obesity has become pandemic owing to an obesogenic environment (inexpensive calorie dense food, technologies and structure of communities that reduce or replace physical activity, and inexpensive nonphysical entertainment) and excessive emphasis on low fat intake resulting in excessive intake of simple carbohydrates and sugar. Effects are greater for women owing to their smaller size and extra weight gain with each pregnancy, with 38% of American adult women being obese. Women are responsible for more than three-fourths of the more than 400 billion dollars of excess direct health care expenditures due to obesity...
March 11, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28271893/marh-a-bifunctional-enzyme-involved-in-the-condensation-and-hydroxylation-steps-of-the-marineosin-biosynthetic-pathway
#2
Wanli Lu, Papireddy Kancharla, Kevin A Reynolds
A novel bifunctional enzyme, MarH, has been identified, and its key functional role in the marineosin biosynthesis successfully probed. MarH catalyzes (1) a condensation step between 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (MBC) and 2-undecylpyrrole (UP) to form undecylprodiginine (UPG) and (2) hydroxylation of the alkyl chain of UPG to form the (S)-23-hydroxyundecylprodiginine (HUPG), which is essential for MarG catalyzed bicyclization toward the formation of an unusual spiro-tetrahydropyran-aminal ring of marineosins...
March 8, 2017: Organic Letters
https://www.readbyqxmd.com/read/28266239/guideline-on-the-diagnosis-and-treatment-of-primary-idiopathic-clubfoot
#3
Arnold T Besselaar, Ralph J B Sakkers, Hans A Schuppers, Melinda M E H Witbreuk, Elgun V C M Zeegers, Jan D Visser, Robert A Boekestijn, Sacha D Margés, M C Marieke Van der Steen, Koert N J Burger
- A delegation of 6 pediatric orthopedic surgeons from the Dutch Orthopedic Association (NOV) and 2 members of the board of the Dutch Parents' Association for children with clubfoot created the guideline "The diagnosis and treatment of primary idiopathic clubfeet" between April 2011 and February 2014. The development of the guideline was supported by a professional methodologist from the Dutch Knowledge Institute of Medical Specialists. This evidence-based guideline process was new and unique, in the sense that the process was initiated by a parents' association...
March 7, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28247031/benefit-on-motor-and-non-motor-behavior-in-a-specialized-unit-for-parkinson-s-disease
#4
Thomas Müller, Gabi Öhm, Kathrin Eilert, Katharina Möhr, Stephanie Rotter, Thomas Haas, Matthias Küchler, Sven Lütge, Marion Marg, Hartmut Rothe
Treatment of patients with Parkinson's disease in specialized units is quite common in Germany. Data on the benefit of this hospitalization of patients with Parkinson's disease on motor and non-motor symptoms in conjunction with standardized tests are rare. Objective was to determine the efficacy of this therapeutic setting. We scored disease severity and performed clinical tests, respectively, instrumental procedures under standardized conditions in consecutively referred in-patients initially and at the end of their hospital stay...
February 28, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28122896/prognostic-significance-of-venous-thromboembolic-events-in-disseminated-germ-cell-cancer-patients
#5
Enrique Gonzalez-Billalabeitia, Daniel Castellano, Nora Sobrevilla, Josep Guma, David Hervas, Maria I Luengo, Jorge Aparicio, Alfonso Sanchez-Muñoz, Begoña Mellado, Alberto Saenz, Claudia Valverde, Antonio Fernandez, Mireia Margeli, Ignacio Duran, Sara Fernandez, Javier Sastre, Silverio Ros, Pablo Maroto, Ray Manneh, Pablo Cerezuela, Alberto Carmona-Bayonas
BACKGROUND: Disseminated germ cell cancers are at high risk of developing thromboembolic complications. We evaluated the prognostic value of venous thromboembolic events (VTE) in disseminated germ cell cancer.  METHODS: Patients with germ cell cancer receiving upfront platinum-containing chemotherapy between 2004 and 2014 were pooled from the Spanish Germ Cell Cancer Group (SGCCG) registry and reviewed for the presence of VTE. Results were validated in an independent international group of patients...
January 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28113186/epidural-spinal-stimulation-to-improve-bladder-bowel-and-sexual-function-in-individuals-with-spinal-cord-injuries-a-framework-for-clinical-research
#6
Roderic I Pettigrew, William J Heetderks, Christine A Kelley, Grace C Y Peng, Steven H Krosnick, Lyn B Jakeman, Katharine D Egan, Michael Marge
While some recent studies that apply epidural spinal cord stimulation (SCS) have demonstrated a breakthrough in improvement of the health and quality of the life of persons with spinal cord injury (SCI), the numbers of people who have received SCS are small. This is in sharp contrast to the thousands of persons worldwide living with SCI who have no practical recourse or hope of recovery of lost functions. Thus, the vision is to understand the full potential of this new intervention and to determine if it is safe and effective in a larger cohort, and if it is scalable so that it can be made available to all those who might benefit...
February 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28092067/interrelations-among-the-adipocytokines-leptin-and-adiponectin-oxidative-stress-and-aseptic-inflammation-markers-in-pre-and-early-pubertal-normal-weight-and-obese-boys
#7
George Paltoglou, Maria Schoina, George Valsamakis, Nicolaos Salakos, Alexandra Avloniti, Athanasios Chatzinikolaou, Alexandra Margeli, Chrysanthi Skevaki, Maria Papagianni, Christina Kanaka-Gantenbein, Ioannis Papassotiriou, George P Chrousos, Ioannis G Fatouros, George Mastorakos
PURPOSE: Presumed interrelationships among deleterious aspects of adipose tissue metabolism, inflammation, and cellular oxidative stress could be influenced by pubertal hormonal changes. They were investigated in pre- and early pubertal normal-weight and obese boys before and after an exercise bout employed as an energy demanding stimulator. METHODS: Cross-sectional study. Seventy-six healthy pre- (mean ± SD, 10.6 ± 0.2 years old, 28 normal-weight, and 11 obese) and early-(11...
January 16, 2017: Endocrine
https://www.readbyqxmd.com/read/28002484/renal-fibrosis-mrna-classifier-validation-in-experimental-lithium-induced-interstitial-fibrosis-in-the-rat-kidney
#8
Hans-Peter Marti, Aaron Jeffs, Andreas Scherer, John Leader, Catherine Leader, Jennifer Bedford, Robert Walker
Accurate diagnosis of fibrosis is of paramount clinical importance. A human fibrosis classifier based on metzincins and related genes (MARGS) was described previously. In this investigation, expression changes of MARGS genes were explored and evaluated to examine whether the MARGS-based algorithm has any diagnostic value in a rat model of lithium nephropathy. Male Wistar rats (n = 12) were divided into 2 groups (n = 6). One group was given a diet containing lithium (40 mmol/kg food for 7 days, followed by 60mmol/kg food for the rest of the experimental period), while a control group (n = 6) was fed a normal diet...
2016: PloS One
https://www.readbyqxmd.com/read/28002175/executive-summary-enhanced-recovery-after-surgery-best-practice-guideline-for-care-of-patients-with-a-fecal-diversion
#9
Debbie Miller, Emily Pearsall, Debra Johnston, Monica Frecea, Marg McKenzie
Enhanced Recovery After Surgery (ERAS) is a multimodal program developed to decrease postoperative complications, improve patient safety and satisfaction, and promote early discharge. In the province of Ontario, Canada, a standardized approach to the care of adult patients undergoing elective colorectal surgery (including benign and malignant diseases) was adopted by 15 hospitals in March 2013. All colorectal surgery patients with or without an ostomy were included in the ERAS program targeting a length of stay of 3 days for colon surgery and 4 days for rectal surgery...
January 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/27989492/a-statistical-method-to-calculate-blood-contamination-in-the-measurement-of-salivary-hormones-in-healthy-women
#10
Guilherme A Behr, Jay P Patel, Marg Coote, Jose C F Moreira, Daniel P Gelain, Meir Steiner, Benicio N Frey
OBJECTIVES: Previous studies have reported that salivary concentrations of certain hormones correlate with their respective serum levels. However, most of these studies did not control for potential blood contamination in saliva. In the present study we developed a statistical method to test the amount of blood contamination that needs to be avoided in saliva samples for the following hormones: cortisol, estradiol, progesterone, testosterone and oxytocin. DESIGN & METHODS: Saliva and serum samples were collected from 38 healthy, medication-free women (mean age=33...
December 16, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27973412/wi-fi-marg-integration-for-indoor-pedestrian-localization
#11
Zengshan Tian, Yue Jin, Mu Zhou, Zipeng Wu, Ze Li
With the wide deployment of Wi-Fi networks, Wi-Fi based indoor localization systems that are deployed without any special hardware have caught significant attention and have become a currently practical technology. At the same time, the Magnetic, Angular Rate, and Gravity (MARG) sensors installed in commercial mobile devices can achieve highly-accurate localization in short time. Based on this, we design a novel indoor localization system by using built-in MARG sensors and a Wi-Fi module. The innovative contributions of this paper include the enhanced Pedestrian Dead Reckoning (PDR) and Wi-Fi localization approaches, and an Extended Kalman Particle Filter (EKPF) based fusion algorithm...
December 10, 2016: Sensors
https://www.readbyqxmd.com/read/27942110/comparison-of-maximum-voluntary-isometric-contraction-of-the-biceps-on-various-posture-and-respiration-conditions-for-normalization-of-electromyography-data
#12
Sang-Yeol Lee, Marg-Eun Jo
[Purpose] Maximum voluntary isometric contraction can increase the reliability of electromyography data by controlling respiration; however, many studies that use normalization of electromyography data fail to account for this. This study aims to check changes in maximum voluntary isometric contraction based on changes in posture and respiration conditions. [Subjects and Methods] Twenty-two healthy volunteers were included in this study. Using 22 healthy subjects, MVIC of the biceps brachii muscle was measured in three respiration conditions: (1) Maximum voluntary isometric contraction during inspiration after maximal expiration, (2) Maximum voluntary isometric contraction during expiration after maximal inspiration and (3) Maximum voluntary isometric contraction during the Valsalva maneuver...
November 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27815153/development-of-a-risk-prediction-score-for-occult-cancer-in-patients-with-venous-thromboembolism
#13
Luis Jara-Palomares, Remedios Otero, David Jimenez, Marc Carrier, Inna Tzoran, Benjamin Brenner, Mireia Margeli, Juan Manuel Praena-Fernandez, Elvira Grandone, Manuel Monreal
BACKGROUND: The benefits of a diagnostic workup for occult cancer in patients with venous thromboembolism (VTE) are controversial. Our aim was to provide and validate a risk score for occult cancer in VTE patients. METHODS: We designed a nested case-control study within a cohort of VTE patients included in the RIETE (Registro Informatizado Enfermedad TromboEmbólica) registry from 2001-2014. CASES: cancer detected beyond the first 30 days after VTE and up for 24 months...
November 1, 2016: Chest
https://www.readbyqxmd.com/read/27808543/a-psychometric-investigation-of-gender-differences-and-common-processes-across-borderline-and-antisocial-personality-disorders
#14
Seokjoon Chun, Alexa Harris, Margely Carrion, Elizabeth Rojas, Stephen Stark, Carl Lejuez, William V Lechner, Marina A Bornovalova
The comorbidity between borderline personality disorder (BPD) and antisocial personality disorder (ASPD) is well-established, and the 2 disorders share many similarities. However, there are also differences across disorders: most notably, BPD is diagnosed more frequently in women and ASPD in men. We investigated if (a) comorbidity between BPD and ASPD is attributable to 2 discrete disorders or the expression of common underlying processes, and (b) if the model of comorbidity is true across sex. Using a clinical sample of 1,400 drug users in residential substance abuse treatment, we tested 3 competing models to explore whether the comorbidity of ASPD and BPD should be represented by a single common factor, 2 correlated factors, or a bifactor structure involving a general and disorder-specific factors...
January 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27806692/essential-conditions-for-the-implementation-of-comprehensive-school-health-to-achieve-changes-in-school-culture-and-improvements-in-health-behaviours-of-students
#15
Kate E Storey, Genevieve Montemurro, Jenn Flynn, Marg Schwartz, Erin Wright, Jill Osler, Paul J Veugelers, Erica Roberts
BACKGROUND: Comprehensive School Health (CSH) is an internationally recognized framework that holistically addresses school health by transforming the school culture. It has been shown to be effective in enhancing health behaviours among students while also improving educational outcomes. Despite this effectiveness, there is a need to focus on how CSH is implemented. Previous studies have attempted to uncover the conditions necessary for successful operationalization, but none have described them in relation to a proven best practice model of implementation that has demonstrated positive changes to school culture and improvements in health behaviours...
November 2, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27760111/the-mcl1-inhibitor-s63845-is-tolerable-and-effective-in-diverse-cancer-models
#16
András Kotschy, Zoltán Szlavik, James Murray, James Davidson, Ana Leticia Maragno, Gaëtane Le Toumelin-Braizat, Maïa Chanrion, Gemma L Kelly, Jia-Nan Gong, Donia M Moujalled, Alain Bruno, Márton Csekei, Attila Paczal, Zoltán B Szabo, Szabolcs Sipos, Gábor Radics, Agnes Proszenyak, Balázs Balint, Levente Ondi, Gábor Blasko, Alan Robertson, Allan Surgenor, Pawel Dokurno, Ijen Chen, Natalia Matassova, Julia Smith, Christopher Pedder, Christopher Graham, Aurélie Studeny, Gaëlle Lysiak-Auvity, Anne-Marie Girard, Fabienne Gravé, David Segal, Chris D Riffkin, Giovanna Pomilio, Laura C A Galbraith, Brandon J Aubrey, Margs S Brennan, Marco J Herold, Catherine Chang, Ghislaine Guasconi, Nicolas Cauquil, Fabien Melchiore, Nolwen Guigal-Stephan, Brian Lockhart, Frédéric Colland, John A Hickman, Andrew W Roberts, David C S Huang, Andrew H Wei, Andreas Strasser, Guillaume Lessene, Olivier Geneste
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but the development of small molecules targeting this protein that are amenable for clinical testing has been challenging. Here we describe S63845, a small molecule that specifically binds with high affinity to the BH3-binding groove of MCL1. Our mechanistic studies demonstrate that S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway...
October 27, 2016: Nature
https://www.readbyqxmd.com/read/27696669/mutant-analysis-by-rescue-gene-excision-new-tools-for-mosaic-studies-in-drosophila
#17
Qingxiang Zhou, Scott J Neal, Francesca Pignoni
A host of classical and molecular genetic tools make Drosophila a tremendous model for the dissection of gene activity. In particular, the FLP-FRT technique for mitotic recombination has greatly enhanced gene loss-of-function analysis. This technique efficiently induces formation of homozygous mutant clones in tissues of heterozygous organisms. However, the dependence of the FLP-FRT method on cell division, and other constraints, also impose limits on its effectiveness. We describe here the generation and testing of tools for Mutant Analysis by Rescue Gene Excision (MARGE), an approach whereby mutant cells are formed by loss of a rescue transgene in a homozygous mutant organism...
November 2016: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/27694113/diversity-outbred-mice-at-21-maintaining-allelic-variation-in-the-face-of-selection
#18
Elissa J Chesler, Daniel M Gatti, Andrew P Morgan, Marge Strobel, Laura Trepanier, Denesa Oberbeck, Shannon McWeeney, Robert Hitzemann, Martin Ferris, Rachel McMullan, Amelia Clayshultle, Timothy A Bell, Fernando Pardo Manuel de Villena, Gary A Churchill
Multi-parent populations (MPPs) capture and maintain the genetic diversity from multiple inbred founder strains to provide a resource for high-resolution genetic mapping through the accumulation of recombination events over many generations. Breeding designs that maintain a large effective population size with randomized assignment of breeders at each generation can minimize the impact of selection, inbreeding, and genetic drift on allele frequencies. Small deviations from expected allele frequencies will have little effect on the power and precision of genetic analysis, but a major distortion could result in reduced power and loss of important functional alleles...
December 7, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27642023/the-scale-scope-coverage-and-capability-of-childbirth-care
#19
REVIEW
Oona M R Campbell, Clara Calvert, Adrienne Testa, Matthew Strehlow, Lenka Benova, Emily Keyes, France Donnay, David Macleod, Sabine Gabrysch, Luo Rong, Carine Ronsmans, Salim Sadruddin, Marge Koblinsky, Patricia Bailey
All women should have access to high quality maternity services-but what do we know about the health care available to and used by women? With a focus on low-income and middle-income countries, we present data that policy makers and planners can use to evaluate whether maternal health services are functioning to meet needs of women nationally, and potentially subnationally. We describe configurations of intrapartum care systems, and focus in particular on where, and with whom, deliveries take place. The necessity of ascertaining actual facility capability and providers' skills is highlighted, as is the paucity of information on maternity waiting homes and transport as mechanisms to link women to care...
October 29, 2016: Lancet
https://www.readbyqxmd.com/read/27579595/relationship-between-inflammatory-biomarkers-and-depressive-symptoms-during-late-pregnancy-and-the-early-postpartum-period-a-longitudinal-study
#20
William Simpson, Meir Steiner, Marg Coote, Benicio N Frey
OBJECTIVE: Perinatal depressive symptoms often co-occur with other inflammatory morbidities of pregnancy. The goals of our study were 1) to examine whether changes in inflammatory markers from the third trimester of pregnancy to 12 weeks postpartum were associated with changes in depressive symptoms; 2) to examine whether third trimester inflammatory markers alone were predictive of postpartum depressive symptoms; and 3) to examine the relationship between inflammatory markers and depressive symptoms during the third trimester of pregnancy and at 12 weeks postpartum...
July 2016: Revista Brasileira de Psiquiatria
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