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https://www.readbyqxmd.com/read/28636872/long-term-postnatal-steroid-effect-in-very-low-birth-weight-infants
#1
YoungAh Youn, Cheong-Jun Moon, In Kyung Sung
We examined whether hydrocortisone exposure ≤ 1week in very low birth weight infants (VLBWI) was associated with poor neurodevelopmental outcomes at corrected 18 months. Further, the clinical factors associated with worse long term outcome were also evaluated. Of a total of 191 VLBWI, the clinical data for these infants relating were retrospectively collected for analysis. Among the 191 VLBWI, 115 (60.2%) infants were exposed to early postnatal hydrocortisone ≤ 1 week of life in our NICU of Seoul St. Mary's Hospital, The Catholic University of Korea between December 2012 and December 2014...
June 18, 2017: Steroids
https://www.readbyqxmd.com/read/28630148/membrane-pores-from-structure-and-assembly-to-medicine-and-technology
#2
Robert J C Gilbert, Hagan Bayley, Gregor Anderluh
No abstract text is available yet for this article.
August 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28627946/-the-connection-between-maltreatment-and-preterm-birth-in-the-light-of-psychomotor-development-at-2-years-old
#3
Anna Szabina Szele, Beáta Erika Nagy
INTRODUCTION: Preterm children' development and harmful affecting factors to development are important aspects of public health, because in our country the number of preterm birth is very high. AIM: Description of psychomotor development of preterm children (Brunet-Lézine; Bayley-III) and connection between psychomotor development and maternal abuse history (own questionnaire). METHOD: Extremely (<1000 g) and very low (1000-1500 g) birth weight preterm children at 23-30 months (n = 35) and their mothers' abuse history were measured...
June 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28625014/comparison-in-executive-function-in-chinese-preterm-and-full-term-infants-at-eight-months
#4
Yao Feng, Hong Zhou, Yan Zhang, Anthony Perkins, Yan Wang, Jing Sun
Executive function (EF) is increasingly recognized as being responsible for adverse developmental outcomes in preterm-born infants. Several perinatal factors may lead to poor EF development in infancy, and the deficits in EF can be identified in infants as young as eight months. A prospective cohort study was designed to study the EF in Chinese preterm infants and examine the relationship between EF in preterm infants and maternal factors during perinatal period. A total of 88 preterm infants and 88 full-term infants were followed from birth to eight months (corrected age)...
June 17, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28623417/a-validated-clinical-mri-injury-scoring-system-in-neonatal-hypoxic-ischemic-encephalopathy
#5
Shamik B Trivedi, Zachary A Vesoulis, Rakesh Rao, Steve M Liao, Joshua S Shimony, Robert C McKinstry, Amit M Mathur
BACKGROUND: Deep nuclear gray matter injury in neonatal hypoxic-ischemic encephalopathy (HIE) is associated with worse neurodevelopmental outcomes. We previously published a qualitative MRI injury scoring system utilizing serial T1-weighted, T2-weighted and diffusion-weighted imaging (DWI), weighted for deep nuclear gray matter injury. OBJECTIVES: To establish the validity of the MRI scoring system with neurodevelopmental outcome at 18-24 months. MATERIALS AND METHODS: MRI scans from neonates with moderate to severe HIE treated with therapeutic hypothermia were evaluated...
June 16, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28622843/fatal-pulmonary-embolism-following-elective-total-knee-replacement-using-aspirin-in-multi-modal-prophylaxis-a-12year-study
#6
C Quah, E Bayley, N Bhamber, P Howard
BACKGROUND: The National Institute for Health and Clinical Excellence (NICE) has issued guidelines on which thromboprophylaxis regimens are suitable following lower limb arthroplasty. Aspirin is not a recommended agent despite being accepted in orthopaedic guidelines elsewhere. We assessed the incidence of fatal pulmonary embolism (PE) and all-cause mortality following elective primary total knee replacement (TKR) with a standardised multi-modal prophylaxis regime in a large teaching district general hospital...
June 13, 2017: Knee
https://www.readbyqxmd.com/read/28619605/the-prognostic-value-of-proton-magnetic-resonance-spectroscopy-in-term-newborns-treated-with-therapeutic-hypothermia-following-asphyxia
#7
Paul E Sijens, Katharina Wischniowsky, Hendrik J Ter Horst
OBJECTIVE: The purpose of this study was to correlate brain metabolism assessed shortly after therapeutic hyperthermia by (1)H magnetic resonance spectroscopy (MRS), with neurodevelopmental outcome. METHODS: At the age of 6.0±1.8days, brain metabolites of 35 term asphyxiated newborns, treated with therapeutic hypothermia, were quantified by multivoxel proton MRS of a volume cranial to the corpus callosum, containing both gray and white matter. At the age of 30months the Bayley Scale of Infant Development-III was performed...
June 12, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28615372/preconception-micronutrient-supplementation-with-iron-and-folic-acid-compared-with-folic-acid-alone-affects-linear-growth-and-fine-motor-development-at-2-years-of-age-a-randomized-controlled-trial-in-vietnam
#8
Phuong H Nguyen, Ines Gonzalez-Casanova, Melissa F Young, Truong Viet Truong, Hue Hoang, Huong Nguyen, Son Nguyen, Ann M DiGirolamo, Reynaldo Martorell, Usha Ramakrishnan
Background: Maternal health and nutrition play a crucial role in early child growth and development. However, little is known about the benefits of preconception micronutrient interventions beyond the role of folic acid (FA) and neural tube defects.Objective: We evaluated the impact of weekly preconception multiple micronutrient (MM) or iron and folic acid (IFA) supplementation on child growth and development through the age of 2 y compared with FA alone.Methods: We followed 1599 offspring born to women who participated in a randomized controlled trial of preconception supplementation in Vietnam...
June 14, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28615305/prenatal-markers-and-longitudinal-follow-up-in-simple-and-complex-gastroschisis
#9
Annelieke Hijkoop, Hanneke IJsselstijn, René M H Wijnen, Dick Tibboel, Joost van Rosmalen, Titia E Cohen-Overbeek
OBJECTIVE: We aimed to identify gestational-age corrected prenatal ultrasound markers of complex gastroschisis, and to compare physical growth and neurodevelopment between children with simple and complex gastroschisis. DESIGN: We included prenatally diagnosed gastroschisis patients from 2000 to 2012 who joined our longitudinal follow-up programme. Associations between complex gastroschisis and prenatal ultrasound markers collected at 30 weeks' gestation and prior to delivery were tested using logistic regression...
June 14, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28608925/osteoradionecrosis-of-the-mandible-in-patients-with-oropharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy
#10
Francesca Caparrotti, Shao Hui Huang, Lin Lu, Scott V Bratman, Jolie Ringash, Andrew Bayley, John Cho, Meredith Giuliani, John Kim, John Waldron, Aaron Hansen, Li Tong, Wei Xu, Brian O'Sullivan, Robert Wood, David Goldstein, Andrew Hope
BACKGROUND: Osteoradionecrosis (ORN) of the mandible is a late toxicity affecting patients treated with radiotherapy for head and neck malignancies. To the authors' knowledge, ORN has no standardized grading system and its reporting is based on retrospective findings in heterogeneous patient populations. The rate of ORN in the era of intensity-modulated radiotherapy (IMRT) still is unknown. METHODS: The authors report the incidence of ORN from prospectively collected data regarding 1196 patients who were diagnosed with squamous cell carcinoma of the oropharynx and treated with curative-intent IMRT, with or without concomitant systemic treatment, from January 2005 to December 2014...
June 13, 2017: Cancer
https://www.readbyqxmd.com/read/28606206/antenatal-depressed-mood-and-child-cognitive-and-physical-growth-at-18-months-in-south-africa-a-cluster-randomised-controlled-trial-of-home-visiting-by-community-health-workers
#11
M Tomlinson, M J Rotheram-Borus, A Scheffler, I le Roux
AIM: To examine the child outcomes at 18-months post-birth of a population cohort of women with antenatal depressed mood, half of whom were randomly chosen to receive perinatal home visits from community health workers during pregnancy. METHOD: Pregnant women in 24 neighbourhoods (98% participation) were randomised by neighbourhood to: (1) standard clinic care (SC; 12 neighbourhoods; n = 594) or (2) the Philani Intervention Program, a home visiting intervention plus standard care (12 neighbourhoods; n = 644)...
June 13, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28605000/hip-arthroscopy-in-patients-less-than-25-years-of-age-in-the-treatment-of-labral-tears-aetiology-and-clinical-outcomes
#12
Gillian Bayley, Stephane Poitras, Gillian Parker, Paul E Beaulé
BACKGROUND: Hip arthroscopy has evolved into a well-established and rapidly growing field of orthopedic surgery for the management of labral tears. The purpose of this study was to review clinical outcomes of patients less than 25 years of age undergoing hip arthroscopy for treatment of a labral tear. METHODS: From 2005 to 2013, 82 hips in 76 patients with mean age of 20.4 (16-25 range) underwent hip arthroscopy for treatment of labral-chondral damage. The Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) and hip disability and osteoarthritis outcome score (HOOS) were recorded at latest follow-up...
June 7, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28589868/-two-year-follow-up-of-infants-born-at-24-weeks-gestation-first-outcomes-following-implementation-of-the-new-guideline-for-perinatal-policy-in-cases-of-extreme-prematurity
#13
C S H Aarnoudse-Moens, M Rijken, R M Swarte, P Andriessen, H J Ter Horst, S M Mulder-de Tollenaer, C Koopman-Esseboom, A R C Laarman, K Steiner, A H B M van der Hoeven, R F Kornelisse, J J Duvekot, N Weisglas-Kuperus
OBJECTIVE: Since 2010 the guideline 'Guideline for perinatal policy in cases of extreme prematurity' has advised an active policy in infants born at 24 weeks gestation. We investigated how infants born at 24 and 25 weeks gestation in the first year following the implementation of the guideline had developed by the age of 2 years. DESIGN: Retrospective national cohort study. METHOD: The study population consisted of all surviving infants born in the Netherlands at 24 or 25 weeks gestation in the period from 1 October 2010 to 1 October 2011...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28585371/influences-of-early-child-nutritional-status-and-home-learning-environment-on-child-development-in-vietnam
#14
Phuong H Nguyen, Ann M DiGirolamo, Ines Gonzalez-Casanova, Melissa Young, Nicole Kim, Son Nguyen, Reynaldo Martorell, Usha Ramakrishnan
Early childhood development plays a key role in a child's future health, educational success, and economic status. However, suboptimal early development remains a global challenge. This study examines the influences of quality of the home learning environment (HOME) and child stunting in the first year of life on child development. We used data collected from a randomized controlled trial of preconceptional micronutrient supplementation in Vietnam (n = 1,458). The Bayley Scales of Infant Development-III were used to assess cognition, language, and motor development domains at 2 years...
June 6, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28577472/general-movement-trajectories-and-neurodevelopment-at-3months-of-age-following-neonatal-surgery
#15
Cathryn Crowle, Karen Walker, Claire Galea, Iona Novak, Nadia Badawi
BACKGROUND: Neonates who undergo major surgery are at risk of neurodevelopmental disability. The General Movements Assessment (GMA) is a valid and reliable method to predict neurodevelopment, however, there are minimal data on the applicability among infants post-surgery. AIM: To describe GMs trajectories following neonatal surgery. STUDY DESIGN: Prospective cohort study. SUBJECTS: 217 infants following major cardiac and non-cardiac neonatal surgery...
May 31, 2017: Early Human Development
https://www.readbyqxmd.com/read/28576299/effects-of-donor-breastmilk-feeding-on-growth-and-early-neurodevelopmental-outcomes-in-preterm-infants-an-observational-study
#16
Laura S Madore, Samudragupta Bora, Carmina Erdei, Tina Jumani, Allison R Dengos, Sarbattama Sen
PURPOSE: Donor breastmilk (DBM) has gained popularity as an alternative to formula when mother's own milk (MOM) is unavailable. The objective of this study was to evaluate the effects of a predominantly DBM diet on growth and subsequent neurodevelopment in preterm infants at a level 3 neonatal intensive care unit (NICU). METHODS: This single-center, observational cohort study compared data from preterm infants supplemented with predominantly (>50%) DBM to those from age- and weight-matched infants fed only MOM or supplemented with predominantly (>50%) preterm formula (PF)...
May 30, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28562255/behavioral-problems-and-socioemotional-competence-at-18-to-22-months-of-extremely-premature-children
#17
Myriam Peralta-Carcelen, Waldemar A Carlo, Athina Pappas, Yvonne E Vaucher, Keith Owen Yeates, Vivien A Phillips, Kathryn E Gustafson, Allison H Payne, Andrea F Duncan, Jamie E Newman, Carla M Bann
BACKGROUND: Behavior and socioemotional development are crucial aspects of child development . METHODS: A total of 2505 children born at <27 weeks' gestation was evaluated at 18 to 22 months' corrected age between January 1, 2008 and December 12, 2012 (86% follow-up). The Brief Infant and Toddler Social and Emotional Assessment was used to evaluate behavioral and socioemotional problems. Cognition and language were evaluated by using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III)...
May 19, 2017: Pediatrics
https://www.readbyqxmd.com/read/28557760/prophylactic-early-erythropoietin-for-neuroprotection-in-preterm-infants-a-meta-analysis
#18
REVIEW
Hendrik S Fischer, Nora J Reibel, Christoph Bührer, Christof Dame
CONTEXT: Recombinant human erythropoietin (rhEPO) is a promising pharmacological agent for neuroprotection in neonates. OBJECTIVE: To investigate whether prophylactic rhEPO administration in very preterm infants improves neurodevelopmental outcomes in a meta-analysis of randomized controlled trials (RCTs). DATA SOURCES: Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched in December 2016 and complemented by other sources...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28557747/supplemental-iodide-for-preterm-infants-and-developmental-outcomes-at-2-years-an-rct
#19
Fiona L R Williams, Simon Ogston, Robert Hume, Jennifer Watson, Kayleigh Stanbury, Peter Willatts, Anita Boelen, Edmund Juszczak, Peter Brocklehurst
BACKGROUND: The recommendation for enteral iodide intake for preterm infants is 30 to 40 μg/kg per day and 1 μg/kg per day for parenteral intake. Preterm infants are vulnerable to iodide insufficiency and thyroid dysfunction. The hypothesis tested whether, compared with placebo, iodide supplementation of preterm infants improves neurodevelopment. METHODS: A randomized controlled trial of iodide supplementation versus placebo in infants <31 weeks' gestation...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28554999/the-impact-of-prenatal-organophosphate-pesticide-exposures-on-thai-infant-neurodevelopment
#20
Pornpimol Kongtip, Benyachalee Techasaensiri, Noppanun Nankongnab, Jane Adams, Akkarat Phamonphon, Anu Surach, Supha Sangprasert, Aree Thongsuksai, Prayoon Srikumpol, Susan Woskie
A birth cohort was begun to investigate the levels and sources of pesticide exposure in pregnant women living in Thailand, and to examine the effects of pesticide exposure on infant neurodevelopment at five months of age. Subjects were interviewed using questionnaires regarding their demographic characteristics, educational background, and work and home activities related to pesticide exposures. Spot urine samples were collected at 28 weeks gestation and analyzed by gas chromatography-mass spectrometry to determine maternal metabolite levels of organophosphate pesticides including dimethyl phosphate (DMP); total DEP (diethyl phosphate (DEP), diethyl thiophosphate (DETP), and diethyl dithiophosphate (DEDTP), and total DAP (the sum of all metabolite levels)...
May 27, 2017: International Journal of Environmental Research and Public Health
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