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https://www.readbyqxmd.com/read/29784284/routine-surveillance-imaging-following-mild-traumatic-brain-injury-with-intracranial-hemorrhage-may-not-be-necessary
#1
Smruti K Patel, Yair M Gozal, Bryan M Krueger, James C Bayley, Suzanne Moody, Norberto Andaluz, Richard A Falcone, Karin S Bierbrauer
BACKGROUND: Mild traumatic brain injury (mTBI) comprises the majority of pediatric traumatic brain injury. Children with mTBI even with traumatic intracranial hemorrhage (tICH) rarely experience a clinically significant neurologic decline (CSND). The utility of routine surveillance imaging in the pediatric population also remains controversial, especially owing to concerns about the risks of radiation exposure at a young age. This study aims to identify demographic or injury-related characteristics that may facilitate recognition of children at risk of progression with mTBI...
April 27, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29777207/clinical-progression-and-metachronous-paragangliomas-in-a-large-cohort-of-sdhd-germline-variant-carriers
#2
Berdine L Heesterman, Lisa M H de Pont, Andel Gl van der Mey, Jean-Pierre Bayley, Eleonora Pm Corssmit, Frederik J Hes, Berit M Verbist, Peter Paul G van Benthem, Jeroen C Jansen
Although it is well established that paternally transmitted germline variants in SDHD are associated with multifocal paragangliomas and lifelong follow-up is generally advised, the risk of metachronous lesions is presently unknown. In a large Dutch cohort of SDHD variant carriers, we studied the development of new paragangliomas, and the evolution of symptoms and cranial nerve impairment. Recurrent event analysis and the Kaplan-Meier product limit estimator were used to study the risk of new lesions. The relation between several predictors and development of new symptoms was assessed using logistic regression...
May 18, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29773970/face-preferences-for-infant-and-adult-directed-speakers-in-infants-of-depressed-and-nondepressed-mothers-association-with-infant-cognitive-development
#3
Peter S Kaplan, Ryan M Asherin, Jo M Vogeli, Shiva M Fekri, Kathryn E Scheyer, Kevin D Everhart
Face preferences for speakers of infant-directed and adult-directed speech (IDS and ADS) were investigated in 4- to 13.5-month-old infants of depressed and non-depressed mothers. Following 1-min of exposure to an ID or AD speaker (order counterbalanced), infants had an immediate paired-comparison test with a still, silent image of the familiarized versus a novel face. In the test phase, ID face preference ratios were significantly lower in infants of depressed than non-depressed mothers. Infants' ID face preference ratios, but not AD face preference ratios, correlated with their percentile scores on the cognitive ( Cog ) scale of the Bayley Scales of Infant & Toddler Development (3rd Edition; BSID III), assessed concurrently...
May 2018: Infancy: the Official Journal of the International Society on Infant Studies
https://www.readbyqxmd.com/read/29767802/sitting-together-and-reaching-to-play-start-play-protocol-for-a-multisite-randomized-controlled-efficacy-trial-on-intervention-for-infants-with-neuromotor-disorders
#4
Regina T Harbourne, Stacey C Dusing, Michele A Lobo, Sarah Westcott-McCoy, James Bovaird, Susan Sheridan, James C Galloway, Hui-Ju Chang, Lin-Ya Hsu, Natalie Koziol, Emily C Marcinowski, Iryna Babik
Background: There is limited research examining the efficacy of early physical therapy on infants with neuromotor dysfunction. In addition, most early motor interventions have not been directly linked to learning, despite the clear association between motor activity and cognition during infancy. Objective: The aim of this project is to evaluate the efficacy of Sitting Together And Reaching To Play (START-Play), an intervention designed to target sitting, reaching, and motor-based problem solving to advance global development in infants with motor delays or neuromotor dysfunction...
June 1, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29765885/comparison-of-second-and-third-editions-of-the-bayley-scales-in-children-with-suspected-developmental-delay
#5
You Gyoung Yi, In Young Sung, Jin Sook Yuk
Objective: To compare the scores of the Bayley Scales of Infant Development second edition (BSID-II) and the third edition, Bayley-III, in children with suspected developmental delay and to determine the cutoff score for developmental delay in the Bayley-III. Methods: Children younger than 42 months (n=62) with suspected developmental delay who visited our department between 2014 and 2015 were assessed with both the BSID-II and Bayley-III tests. Results: The mean Bayley-III Cognitive Language Composite (CLC) score was 5...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29765884/visual-evoked-potential-in-children-with-developmental-disorders-correlation-with-neurodevelopmental-outcomes
#6
JaYoung Kim, In Young Sung, Eun Jae Ko, Minji Jung
Objective: To investigate the neurodevelopmental outcomes in children with developmental disorder according to visual evoked potential (VEP) results. Methods: We retrospectively analyzed children who visited our Department of Pediatric Rehabilitation Medicine with a chief complaint of developmental disability from January 2001 to July 2015. Of the 549 medical records reviewed, 322 children younger than 42 months who underwent both Bayley Scales of Infant and Toddler Development second edition (BSID-II) and VEP studies were enrolled...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29753346/clinical-outcome-assessments-use-of-normative-data-in-a-pediatric-rare-disease
#7
Dawn Phillips, Beth Leiro
Pediatric rare diseases present unique challenges in clinical trial design and in selection of clinical outcome assessments (COAs) used to support claims in medical product labeling. COAs that discriminate level of function relative to a normative sample are particularly important in the pediatric rare disease setting because the literature is often void of natural history data. Pediatric rare disease clinical trials will often include a wide age distribution. Gross and fine motor skills, communication, cognition, and independence in activities of daily living vary by age, and it may be difficult to distinguish between treatment effect and change due to developmental maturation...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29751424/prenatal-mercury-exposure-fish-intake-and-neurocognitive-development-during-first-three-years-of-life-prospective-cohort-mothers-and-children-s-environmental-health-moceh-study
#8
Yeni Kim, Eun-Hee Ha, Hyesook Park, Mina Ha, Yangho Kim, Yun-Chul Hong, Eun Jung Lee, Hyesook Kim, Namsoo Chang, Bung-Nyun Kim
OBJECTIVES: In this prospective cohort study, the effects of prenatal Hg exposure on neurocognitive development during the first 3years of life were investigated. METHODS: The maternal blood levels of Hg were assessed during pregnancy and in cord blood. Maternal fish intake was assessed by interviewing the weekly frequency of fish intake during pregnancy. Maternal n-3 and n-6 fatty acid intake was estimated based on 24h recall food intake interview. The mental (MDI) and psychomotor (PDI) development index scores were assessed using the Bayley Scales of Infant Development at 6, 12, 24, 36months of age...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29742027/dendritic-ca2-dynamics-and-multi-modal-processing-in-a-cricket-antennal-interneuron
#9
Timothy George Bayley, Berthold Hedwig
The integration of stimuli of different modalities is fundamental to information processing within the nervous system. A descending interneuron in the cricket brain, with prominent dendrites in the deutocerebrum, receives input from three sensory modalities: touch of the antennal flagellum, strain of the antennal base, and visual stimulation. Using calcium imaging, we demonstrate that each modality drives a Ca2+ increase in a different dendritic region. Moreover, touch of the flagellum is represented in a topographic map along the neuron's dendrites...
May 9, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29739092/satb2-associated-syndrome-a-case-report-of-a-de-novo-nonsense-mutation-in-satb2-from-china-and-review-of-literature
#10
Hong-Yan Lv, Rui-Jiang Zheng, Qiu-Li Wang, Peng-Shun Ren, Lin-Hong Jin, Xiu-Ling Gu, Lian-Xiang Li
BACKGROUND: To study the clinical and genetic features from a Chinese child with SATB2-associated syndrome (SAS) and review of literature. METHODS: The girl, 2 years 3 months old, is admitted to the Department of Pediatric Rehabilitation in our hospital. This patient has mental retardation, language development disorder, cleft palate II0, micrognathia, malocclusion, irritability and bilateral oblique palpebral fissure as a clinical manifestation and is treated for 3 months...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29733356/growth-parameters-at-birth-mediate-the-relationship-between-prenatal-manganese-exposure-and-cognitive-test-scores-among-a-cohort-of-2-to-3-year-old-bangladeshi-children
#11
Jane J Lee, Linda Valeri, Kush Kapur, Md Omar Sharif Ibne Hasan, Quazi Quamruzzaman, Robert O Wright, David C Bellinger, David C Christiani, Maitreyi Mazumdar
Background: Our previous study demonstrated that prenatal manganese exposure is associated with cognitive test scores among a cohort of 2- to 3-year-old Bangladeshi children. This study tested the hypothesis that the adverse effects of manganese are mediated through poor prenatal growth. Methods: Pregnant mothers were enrolled in a birth cohort in Bangladesh between 2008 and 2011, and children were followed at birth and age 20-40 months. Manganese concentration was measured in umbilical cord blood...
May 3, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29730131/relationship-between-mother-infant-mutual-dyadic-responsiveness-and-premature-infant-development-as-measured-by-the-bayley-iii-at-6-weeks-corrected-age
#12
Rosemary C White-Traut, Kristin M Rankin, Joe Yoder, Laura Zawacki, Suzann Campbell, Meredith Censullo, Karen Kavanaugh, Kathleen F Norr
BACKGROUND: The quality of mother-preterm infant interaction has been identified as a key factor in influencing the infant's later development and language acquisition. The relationship between mother-infant responsiveness and later development may be evident early in infancy, a time period which has been understudied. AIM: Describe the relationship between mother-infant mutual dyadic responsiveness and premature infant development. DESIGN: This study employed a secondary analysis of data from the 6-week corrected age (CA) follow-up visit of the Hospital-Home Transition: Optimizing Prematures' Environment (H-HOPE) study, a randomized clinical trial testing the efficacy of a mother- and infant- focused intervention for improving outcomes among premature infants...
May 3, 2018: Early Human Development
https://www.readbyqxmd.com/read/29730062/partial-laryngeal-imrt-for-t2n0-glottic-cancer-impact-of-image-guidance-and-radiation-therapy-intensification
#13
Kathy Rock, Shao Hui Huang, Albert Tiong, Lin Lu, Wei Xu, Jolie Ringash, Scott V Bratman, Li Tong, Biu Chan, John Cho, Meredith Giuliani, Andrew Hope, Andrew Bayley, John Kim, John R de Almeida, Brian O'Sullivan, John Waldron
PURPOSE: To assess the impact of the radiation therapy (RT) regimen and image guidance (image guided radiation therapy [IGRT]) protocol on local control (LC) for T2N0 glottic cancer treated with partial laryngeal intensity modulated radiation therapy (IMRT). METHODS AND MATERIALS: All patients with T2N0 glottic cancer treated with IMRT from 2006 to 2013 at a single institution were retrospectively reviewed. The gross tumor volume (GTV), delineated from endoscopic and/or radiologic findings, was expanded 0...
March 30, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29726819/histone-methyltransferase-ezh2-a-therapeutic-target-for-ovarian-cancer
#14
REVIEW
Bayley A Jones, Sooryanarayana Varambally, Rebecca C Arend
Ovarian cancer is the fifth leading cause of cancer-related deaths in females in the United States. There were an estimated 22,440 new cases and 14,080 deaths due to ovarian cancer in 2017. Most patients present with advanced-stage disease, revealing the urgent need for new therapeutic strategies targeting pathways of tumorigenesis and chemotherapy resistance. While multiple genomic changes contribute to the progression of this aggressive disease, it has become increasingly evident that epigenetic events play a pivotal role in ovarian cancer development...
March 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29724352/neonatal-brain-injury-and-timing-of-neurodevelopmental-assessment-in-patients-with-congenital-heart-disease
#15
Shabnam Peyvandi, Vann Chau, Ting Guo, Duan Xu, Hannah C Glass, Anne Synnes, Kenneth Poskitt, A James Barkovich, Steven P Miller, Patrick S McQuillen
BACKGROUND: Brain injury (BI) is reported in 60% of newborns with critical congenital heart disease as white matter injury (WMI) or stroke. Neurodevelopmental (ND) impairments are reported in these patients. The relationship between neonatal BI and ND outcome has not been established. OBJECTIVES: This study sought to determine the association between peri-operative BI and ND outcomes in infants with single ventricle physiology (SVP) and d-transposition of the great arteries (d-TGA)...
May 8, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29712949/association-between-maternal-exposure-to-phthalates-and-lower-language-ability-in-offspring-derived-from-hair-metabolome-analysis
#16
Beatrix Jones, Ting-Li Han, Thibaut Delplancke, Elizabeth J McKenzie, Jamie V de Seymour, Mei Chien Chua, Kok Hian Tan, Philip N Baker
The fetus undergoes a crucial period of neurodevelopment in utero. The maternal hair metabolome provides an integrated record of the metabolic state of the mother prior to, and during pregnancy. We investigated whether variation in the maternal hair metabolome was associated with neurodevelopmental differences across infants. Maternal hair samples and infant neurocognitive assessments (using the Bayley III Scales of Infant Development at 24 months) were obtained for 373 infant-mother dyads between 26-28 weeks' gestation from the Growing Up in Singapore Towards Healthy Outcomes cohort...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29710034/the-relationship-between-maternal-serum-vitamin-d-levels-and-infant-neurodevelopment-and-anthropometry-a-prospective-observational-study
#17
Mei-Zhu Chi, Lin Zhu, Zeng-Li Zhang, Fang-Fang Jin, Hao-Ran Shao, Jia-Yin Zheng, Chao Wu, Guang-Qiong Hu
This study was designed to determine whether there is a relationship between serum vitamin D levels and neurodevelopment and anthropometry in Chinese infants. A prospective cohort study with 160 women who gave birth to 160 healthy full-term infants and who were followed up for 6 mo was done. It included 80 pregnant women with vitamin D deficiency, and the other 80 pregnant women were enrolled matching the age and delivery method with a 25(OH)D level of more than 50 nmol/L. There was a signicant intergroup difference in length, weight or head circumference at birth (p<0...
2018: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29708221/relationships-between-full-day-arm-movement-characteristics-and-developmental-status-in-infants-with-typical-development-as-they-learn-to-reach-an-observational-study
#18
Joanne Shida-Tokeshi, Christianne J Lane, Ivan A Trujillo-Priego, Weiyang Deng, Douglas L Vanderbilt, Gerald E Loeb, Beth A Smith
Background: Advances in wearable sensor technology now allow us to quantify the number, type and kinematic characteristics of bouts of infant arm movement made across a full day in the natural environment. Our aim here was to determine whether the amount and kinematic characteristics of arm movements made across the day in the natural environment were related to developmental status in infants with typical development as they learned to reach for objects using their arms. Methods: We used wearable sensors to measure arm movement across days and months as infants developed arm reaching skills...
April 5, 2018: Gates open research
https://www.readbyqxmd.com/read/29696050/are-the-norms-of-bayley-screening-test-appropriate-for-persian-language-children
#19
Farin Soleimani, Nadia Azari, Roshanak Vameghi, Firoozeh Sajedi, Soheila Shahshahani, Hossein Karimi, Adis Kraskian, Amin Shahrokhi, Robab Teymouri, Masoud Gharib, Nayereh Mehdipour
Objective: We aimed to assess the distribution of the Bayley screening test by age, and compare developmental risk category distributions between Persian language children and reference norms. Materials & Methods: A representative sample of 417 children, 1 to 42-months-old, by consecutive sampling from health -care centers were enrolled, during 2014 to 2015 in Tehran, Iran. The cognitive, language and motor development of children were evaluated using Bayley screening test...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29694295/psychological-functioning-of-women-taking-illicit-drugs-during-pregnancy-and-the-growth-and-development-of-their-offspring-in-early-childhood
#20
Dana Serino, Bradley S Peterson, Tove S Rosen
OBJECTIVE: Assess psychosocial history and psychological functioning in women who use drugs during pregnancy and determine how drug exposure affects child development. METHODS: Pregnant marijuana (n = 38), cocaine (n = 35), methadone-maintained (n = 24), and control (n = 49) group women were enrolled and followed every 6 months through 18-24 months postnatally. RESULTS: There was a significantly higher incidence of mental illness in mothers in the drug groups...
April 25, 2018: Journal of Dual Diagnosis
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