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https://www.readbyqxmd.com/read/28722635/early-life-inflammation-and-neurodevelopmental-outcome-in-bangladeshi-infants-growing-up-in-adversity
#1
Nona M Jiang, Fahmida Tofail, Jennie Z Ma, Rashidul Haque, Beth Kirkpatrick, Charles A Nelson, William A Petri
Exposure to profound adversity can negatively affect the neurodevelopment of children, but biologic mechanisms that underlie this association remain unknown. We sought to determine whether elevated levels of the inflammatory markers C-reactive protein (CRP) and soluble CD14 (sCD14) are associated with neurodevelopmental outcomes in Bangladeshi children. A total of 422 infant-mother pairs from an urban slum in Dhaka, Bangladesh, were enrolled at birth and followed prospectively. Inflammation was measured with sCD14, interleukin (IL)-1β, and IL-6 at 18 weeks, and CRP at 6, 18, 40, and 53 weeks...
July 17, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28720023/early-motor-development-and-cognitive-abilities-among-mexican-preschoolers
#2
Erika Osorio-Valencia, Luisa Torres-Sánchez, Lizbeth López-Carrillo, Stephen J Rothenberg, Lourdes Schnaas
Psychomotricity plays a very important role in children's development, especially for learning involving reading-writing and mathematical calculations. Evaluate motor development in children 3 years old and its relationship with their cognitive abilities at the age of 5 years. Based on a cohort study, we analyzed the information about motor performance evaluated at 3 years old by Peabody Motor Scale and cognitive abilities at 5 years old. The association was estimated using linear regression models adjusted by mother's intelligence quotient, sex, Bayley mental development index at 18 months, and quality of the environment at home (HOME scale)...
July 18, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28716072/effect-of-prenatal-exposure-to-maternal-cortisol-and-psychological-distress-on-infant-development-in-bengaluru-southern-india-a-prospective-cohort-study
#3
Anita Nath, Gudlavalleti Venkata Satyanarayana Murthy, Giridhara R Babu, Gian Carlo Di Renzo
BACKGROUND: The mental health status of a pregnant woman and its consequent impact on foetal well being is not given much importance compared to the risk imposed by obstetric complications and medical conditions. Maternal psychological distress is a major public health problem and needs timely detection and intervention to prevent any adverse pregnancy outcome. There is ample evidence from literature that justifies the association of prenatal maternal mental stress and elevated cortisol with delayed infant motor and cognitive development; evidence from India being rather limited...
July 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28715787/micronutrients-during-pregnancy-and-child-psychomotor-development-opposite-effects-of-zinc-and-selenium
#4
Kinga Polanska, Wojciech Hanke, Anna Krol, Jolanta Gromadzinska, Renata Kuras, Beata Janasik, Wojciech Wasowicz, Fiorino Mirabella, Flavia Chiarotti, Gemma Calamandrei
Studies on the impact of micronutrient levels during different pregnancy periods on child psychomotor functions are limited. The aim of this study was to evaluate the association between maternal plasma concentrations of selected micronutrients, such as: copper (Cu), zinc (Zn), selenium (Se), and child neuropsychological development. The study population consisted of 539 mother-child pairs from Polish Mother and Child Cohort (REPRO_PL). The micronutrient levels were measured in each trimester of pregnancy, at delivery and in the cord blood...
July 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28714930/environmental-tobacco-smoke-exposure-during-pregnancy-and-child-neurodevelopment
#5
Kinga Polanska, Anna Krol, Dorota Merecz-Kot, Danuta Ligocka, Karolina Mikolajewska, Fiorino Mirabella, Flavia Chiarotti, Gemma Calamandrei, Wojciech Hanke
The developing fetus is especially vulnerable to environmental toxicants, including tobacco constituents. The aim of this study was to assess the impact of environmental tobacco smoke (ETS) exposure during pregnancy on child neurodevelopment within the first two years of life. The study population consisted of 461 non-smoking pregnant women (saliva cotinine level <10 ng/mL). Maternal passive smoking was assessed based on the cotinine level in saliva analyzed by the use of high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-ESI + MS/MS) and by questionnaire data...
July 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28714339/inhaled-and-systemic-steroid-exposure-and-neurodevelopmental-outcome-of-preterm-neonates
#6
Edmond N Kelly, Vibhuti S Shah, Jody Levenbach, Michael Vincer, Orlando DaSilva, Prakesh S Shah
OBJECTIVES: To compare death and/or neurodevelopmental outcomes of preterm infants exposed to inhaled and/or systemic steroids with those without exposure, and examine the impact of timing of exposure. METHODS: Retrospective study of infants born <29 weeks gestation and assessed at 18-21 months corrected age (CA). Neurodevelopmental impairment (NDI) was defined as any Bayley Scales of Infant and Toddler Development-III (BSID-III) score <85, cerebral palsy ≥ grade one, and visual or hearing impairment...
July 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28711562/early-executive-function-differences-in-infants-born-moderate-to-late-preterm
#7
Amanda S Hodel, Kate L Senich, Claire Jokinen, Oren Sasson, Alyssa R Morris, Kathleen M Thomas
Individuals who are born very preterm (<32weeks gestation) show differential development of prefrontal cortex structure, function, and dependent behaviors, including executive function (EF) skills, beginning during late infancy and extending into adulthood. Preschool-aged children born moderate-to-late preterm (PT; 32-36weeks gestation) show smaller discrepancies in EF development, but it is unclear whether these differences first emerge during the early childhood years, when EF is rapidly developing, or if they arise from alterations in complex cognitive skills measurable in late infancy...
July 13, 2017: Early Human Development
https://www.readbyqxmd.com/read/28704672/anthropometric-measures-at-birth-and-early-childhood-are-associated-with-neurodevelopmental-outcomes-among-bangladeshi-children-aged-2-3years
#8
Jane J Lee, Kush Kapur, Ema G Rodrigues, Md Omar Sharif Ibne Hasan, Quazi Quamruzzaman, Robert O Wright, David C Bellinger, David C Christiani, Maitreyi Mazumdar
Among a cohort of children located in rural areas of Bangladesh affected by high levels of exposure to environmental metals, we investigated the associations between anthropometric measures, growth trajectory, and neurodevelopment at age 20-40months. Our study population included mothers and their children who participated in a longitudinal birth cohort study that took in place in the Pabna and Sirajdikhan areas of Bangladesh. Anthropometric measures including weight, length, and head circumference were measured at birth, age 12months, and age 20-40months...
July 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28697405/neurodevelopmental-outcome-of-italian-preterm-children-at-1year-of-corrected-age-by-bayley-iii-scales-an-assessment-using-local-norms
#9
Corinna Gasparini, Barbara Caravale, Monica Rea, Maria Franca Coletti, Valentina Tonchei, Silvia Bucci, Andrea Dotta, Mario De Curtis, Simonetta Gentile, Rosa Ferri
BACKGROUND: Premature birth is often associated with neurodevelopmental difficulties throughout childhood. In the first three years of life, the Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III) constitute one of the most used tools for assessing child development. Since Bayley-III original norms are based on United States (US) population, it remains uncertain whether their use in other countries (e.g., European) is appropriate. AIMS: This research aimed to examine neurodevelopment of preterm infants and full-term infants, using Bayley-III US norms in comparison to Italian (IT) norms...
July 8, 2017: Early Human Development
https://www.readbyqxmd.com/read/28693088/-study-of-the-relevant-factors-of-behavioral-development-among-30-month-old-infants-in-rural-area-of-shaanxi-province
#10
X Yang, Z H Zhu, M Zhang, D Y Li, D L Liu, Y Cheng, H Yan, L X Zeng
Objective: To explore the relevant factors of behavioral development among 30-month-old infants in rural area, Shaanxi Province. Methods: The behavioral development among 977 infants aged 30-month-old was evaluated in Changwu and Binxian of Shaanxi province from July 2006 to August 2008. The inclusion criteria included single live birth between January 2004 and February 2006, mother had participated in a community-based intervention study named "Impact of multi-micronutrient supplementation during pregnancy on low birth weight and premature delivery" ...
July 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28692578/turning-1-year-of-age-in-a-low-socioeconomic-environment-a-portrait-of-disadvantage
#11
Hallam Hurt, Laura M Betancourt
In the United States today, 16 million children are growing up poor. Few studies report multiple environmental factors associated with poverty during the first year of life and effects on infant development. OBJECTIVES: To evaluate maternal, home, and neighborhood environment of low and higher socioeconomic status (SES) infants from birth to 1 year and to evaluate the impact of SES and environment on infant developmental outcome at 1 year. METHODS: Low (n = 30) and higher SES (n = 30) African-American mothers and their healthy term gestation female infants were prospectively compared for environmental characteristics and infant developmental outcome...
June 29, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28687527/the-first-patient-with-sporadic-x-linked-intellectual-disability-with-de-novo-zdhhc9-mutation-identified-by-targeted-next-generation-sequencing
#12
Ji Yoon Han, In Goo Lee, Soyoung Shin, Myungshin Kim, Ja Hyun Jang, Joonhong Park
X-linked intellectual disability (XLID) is a genetically heterogeneous disorder involving more than 100 genes known to date. Here, we describe a Korean male infant with global developmental delay. He had neither facial dysmorphism nor skeletal abnormalities. Bayley scale of infant and toddler development third edition (Bayley-III) measured at age of 2 years revealed marked global developmental delays without Marfanoid habitus, structural brain abnormalities, or epilepsy. The patient's cognitive, motor, and language developmental ages were 8-9 months, 12 months, and 9 months, respectively...
July 4, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28684229/reverse-shoulder-endoprosthesis-for-pathologic-lesions-of-the-proximal-humerus-a-minimum-3-year-follow-up
#13
Simon Maclean, Shahbaz S Malik, Scott Evans, Jonathan Gregory, Lee Jeys
BACKGROUND: The Bayley Walker (Stanmore Implants, Elstree, UK) reversed polarity, linked shoulder replacement is designed to provide stable function in the treatment of a painful shoulder with poor soft tissue coverage. We reviewed the results of the prosthesis in destructive pathologic lesions of the proximal humerus at a United Kingdom tumor center. METHODS: We identified 8 patients (2 men, 6 women) in our database. Clinical information and functional outcome scores were collected, including range of movement, Toronto Extremity Salvage Score, the Musculoskeletal Tumor Score...
July 3, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28672318/effect-of-depth-and-duration-of-cooling-on-death-or-disability-at-age-18-months-among-neonates-with-hypoxic-ischemic-encephalopathy-a-randomized-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Seetha Shankaran, Abbot R Laptook, Athina Pappas, Scott A McDonald, Abhik Das, Jon E Tyson, Brenda B Poindexter, Kurt Schibler, Edward F Bell, Roy J Heyne, Claudia Pedroza, Rebecca Bara, Krisa P Van Meurs, Carolyn M Petrie Huitema, Cathy Grisby, Uday Devaskar, Richard A Ehrenkranz, Heidi M Harmon, Lina F Chalak, Sara B DeMauro, Meena Garg, Michelle E Hartley-McAndrew, Amir M Khan, Michele C Walsh, Namasivayam Ambalavanan, Jane E Brumbaugh, Kristi L Watterberg, Edward G Shepherd, Shannon E G Hamrick, John Barks, C Michael Cotten, Howard W Kilbride, Rosemary D Higgins
Importance: Hypothermia for 72 hours at 33.5°C for neonatal hypoxic-ischemic encephalopathy reduces death or disability, but rates continue to be high. Objective: To determine if cooling for 120 hours or to a temperature of 32.0°C reduces death or disability at age 18 months in infants with hypoxic-ischemic encephalopathy. Design, Setting, and Participants: Randomized 2 × 2 factorial clinical trial in neonates (≥36 weeks' gestation) with hypoxic-ischemic encephalopathy at 18 US centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network between October 2010 and January 2016...
July 4, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28666462/two-distinct-mtorc2-dependent-pathways-converge-on-rac1-to-drive-breast-cancer-metastasis
#15
Meghan Morrison Joly, Michelle M Williams, Donna J Hicks, Bayley Jones, Violeta Sanchez, Christian D Young, Dos D Sarbassov, William J Muller, Dana Brantley-Sieders, Rebecca S Cook
BACKGROUND: The importance of the mTOR complex 2 (mTORC2) signaling complex in tumor progression is becoming increasingly recognized. HER2-amplified breast cancers use Rictor/mTORC2 signaling to drive tumor formation, tumor cell survival and resistance to human epidermal growth factor receptor 2 (HER2)-targeted therapy. Cell motility, a key step in the metastatic process, can be activated by mTORC2 in luminal and triple negative breast cancer cell lines, but its role in promoting metastases from HER2-amplified breast cancers is not yet clear...
June 30, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28665786/maternal-and-cord-blood-manganese-concentrations-and-early-childhood-neurodevelopment-among-residents-near-a-mining-impacted-superfund-site
#16
Birgit Claus Henn, David C Bellinger, Marianne R Hopkins, Brent A Coull, Adrienne S Ettinger, Rebecca Jim, Earl Hatley, David C Christiani, Robert O Wright
BACKGROUND: Environmental manganese exposure has been associated with adverse neurodevelopmental outcomes among school-aged children; yet, few studies have evaluated prenatal exposure. OBJECTIVES: Our study examines associations between prenatal manganese concentrations and placental transfer of manganese with neurodevelopment in 224 2-y-old children residing near the Tar Creek Superfund Site. METHODS: We collected maternal and cord blood at delivery, measured manganese using inductively coupled plasma mass spectrometry, and assessed neurodevelopment using the Bayley Scales of Infant Development-II...
June 28, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28659361/parenting-stress-trajectories-in-mothers-of-very-preterm-infants-to-2-years
#17
Peter H Gray, Dawn M Edwards, Kristen Gibbons
OBJECTIVE: To examine levels of parenting stress in mothers of preterm and term infants when the children were 2 years old; to determine the trajectory of stress over three time periods and to examine the association of maternal and neonatal factors and developmental outcomes with parenting stress. DESIGN: It is a prospective longitudinal study to determine parenting stress in mothers of preterm and term infants with outcomes having been previously obtained at 4 and 12 months...
June 28, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28651530/perspectives-of-health-care-professionals-on-the-facilitators-and-barriers-to-the-implementation-of-a-stroke-rehabilitation-guidelines-cluster-randomized-controlled-trial
#18
Sarah E P Munce, Ian D Graham, Nancy M Salbach, Susan B Jaglal, Carol L Richards, Janice J Eng, Johanne Desrosiers, Marilyn MacKay-Lyons, Sharon Wood-Dauphinee, Nicol Korner-Bitensky, Nancy E Mayo, Robert W Teasell, Merrick Zwarenstein, Jennifer Mokry, Sandra Black, Mark T Bayley
BACKGROUND: The Stroke Canada Optimization of Rehabilitation by Evidence Implementation Trial (SCORE-IT) was a cluster randomized controlled trial that evaluated two knowledge translation (KT) interventions for the promotion of the uptake of best practice recommendations for interventions targeting upper and lower extremity function, postural control, and mobility. Twenty rehabilitation centers across Canada were randomly assigned to either the facilitated or passive KT intervention. The objective of the current study was to understand the factors influencing the implementation of the recommended treatments and KT interventions from the perspective of nurses, occupational therapists and physical therapists, and clinical managers following completion of the trial...
June 26, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28636872/long-term-postnatal-steroid-effect-in-very-low-birth-weight-infants
#19
YoungAh Youn, Cheong-Jun Moon, In Kyung Sung
We examined whether hydrocortisone exposure ≤ 1week in very low birth weight infants (VLBWI) was associated with poor neurodevelopmental outcomes at corrected 18 months. Further, the clinical factors associated with worse long term outcome were also evaluated. Of a total of 191 VLBWI, the clinical data for these infants relating were retrospectively collected for analysis. Among the 191 VLBWI, 115 (60.2%) infants were exposed to early postnatal hydrocortisone ≤ 1 week of life in our NICU of Seoul St. Mary's Hospital, The Catholic University of Korea between December 2012 and December 2014...
June 18, 2017: Steroids
https://www.readbyqxmd.com/read/28630148/membrane-pores-from-structure-and-assembly-to-medicine-and-technology
#20
Robert J C Gilbert, Hagan Bayley, Gregor Anderluh
No abstract text is available yet for this article.
August 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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