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"Acute tubulointerstitial nephritis"

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https://www.readbyqxmd.com/read/28190920/acute-alloxan-renal-toxicity-in-the-rat-initially-causes-degeneration-of-thick-ascending-limbs-of-henle
#1
Yui Terayama, Yasushi Kodama, Tetsuro Matsuura, Kiyokazu Ozaki
Alloxan (AL) is a material well-known to induce diabetes. Prior to inducing a prolonged diabetic state, AL causes acute tubulointerstitial nephritis. However, the precise primary target site and mechanism of its nephrotoxicity remain unclear. The objective of this study was to evaluate the morphological characteristics relevant to acute renal toxicity following AL administration. Rats were intravenously treated with AL. Eight hours after AL treatment, aquaporin 1-negative and Na/K pump-positive thick ascending limbs of Henle (TAL) were degenerated in the outer medulla...
January 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28184344/a-case-of-acute-tubulointerstitial-nephritis-associated-with-rifampin-therapy-presenting-as-fanconi-like-syndrome
#2
Jun Tae Park, Sik Lee, Won Kim, Sung Kwang Park, Kyung Pyo Kang
No abstract text is available yet for this article.
January 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28098119/acute-tubulointerstitial-nephritis-and-uveitis-syndrome-a-report-on-four-adult-cases
#3
Yosra Ben Ariba, Jannet Labidi, Zied Elloumi, Yosra Selmi, Salah Othmani
Acute tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, generally presenting in children and young women. The interstitial nephritis may precede, follow, or develop concurrent to the uveitis. We report the clinical features and outcomes of four adult patients, aged 41-70 years with the TINU syndrome.
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28018458/successful-treatment-of-tubulointerstitial-nephritis-and-uveitis-with-steroid-and-azathioprine-in-a-12-year-old-boy
#4
Ji Eun Kim, Se Jin Park, Ji Young Oh, Hyeon Joo Jeong, Ji Hong Kim, Jae Il Shin
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, often underdiagnosed or misdiagnosed in children. We describe the case of a 12-year-old boy who presented to Severance Hospital with a 1-month history of bilateral conjunctival injection. He was first evaluated by an Ophthalmologist in another hospital and diagnosed with panuveitis. Laboratory tests indicated renal failure, and a renal biopsy confirmed the diagnosis of acute tubulointerstitial nephritis. An extensive exclusion of all possible causes allowed a diagnosis of TINU syndrome...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27959848/-tubulointerstitial-nephritis-syndrome-and-uveitis
#5
Carolina A Isnardi, Andrés Vilela, Pablo Kuschner, Carolina Salvo, Cecilia Vanzetti, Hugo Zelechower, Adriana Arpa
Intermediate uveitis is described as inflammation in the anterior vitreous, ciliary body and the peripheral retina. It is a subset of uveitis where the vitreous is the major site of damage. It has been reported to be associated with many local and systemic inflammatory and infectious diseases. An infrequent cause is the tubulointerstitial nephritis and uveitis syndrome. We report a case of an acute visual acuity loss related with renal failure in a 64 years old woman with Hashimoto disease. It was an acute tubulointerstitial nephritis and uveitis syndrome case...
2016: Medicina
https://www.readbyqxmd.com/read/27781207/reversal-of-gastric-bypass-resolves-hyperoxaluria-and-improves-oxalate-nephropathy-secondary-to-roux-en-y-gastric-bypass
#6
Varun Agrawal, Jonathan B Wilfong, Christopher E Rich, Pamela C Gibson
Hyperoxaluria after Roux-en-Y gastric bypass (RYGB) increases the risk for kidney injury. Medical therapies for hyperoxaluria have limited efficacy. A 65-year-old female was evaluated for acute kidney injury [AKI, serum creatinine (Cr) 2.1 mg/dl, baseline Cr 1.0 mg/dl]. She did not have any urinary or gastrointestinal symptoms or exposure to nephrotoxic agents. Sixteen months prior to this evaluation, she underwent RYGB for morbid obesity. Her examination was unremarkable for hypertension or edema and there was no protein or blood on urine dipstick...
September 2016: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/27737399/acute-tubulointerstitial-nephritis-with-severe-renal-impairment-associated-with-multisystem-igg4-related-disease
#7
Rafael Coimbra Ferreira Beltrame, Maurício Friderichs, Bárbara Rayanne Fior, Pedro Guilherme Schaefer, Gustavo Gomes Thomé, Dirceu Reis da Silva, Elvino José Guardão Barros, Renato Seligman, Francisco Veríssimo Veronese
The IgG4-related disease has a wide clinical spectrum where multiple organs can be affected, and the diagnosis depends on typical histopathological findings and an elevated IgG4 expression in plasma cells in the affected tissue. We describe the clinical presentation and evolution of a patient with acute tubulointerstitial nephritis, severe kidney failure and systemic manifestations such as lymphadenomegaly and chronic pancreatitis. The diagnosis was confirmed by the clinical picture and kidney and lymph node histopathology, in which immunohistochemistry of the lymphoid tissue showed policlonality and increased expression of IgG4, with a IgG4/total IgG ratio > 80%...
July 2016: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/27735794/acute-tubulointerstitial-nephritis-a-case-series-and-long-term-renal-outcomes
#8
Aysel Taktak, Nermin Uncu, Banu Acar, Şemsa Çaycı, Arzu Ensari, Gökçe Gür, Adem Köksoy, Nilgün Çakar
Acute tubulointerstitial nephritis (TIN) is a common cause of acute renal impairment, characterized by the infiltration of inflammatory cells in the interstitium of the kidney. We retrospectively reviewed the medical records of 19 acute TIN patients attended to our Pediatric Nephrology department between April 1999 and April 2014. Nineteen patients (7 boys and 12 girls) were evaluated. The median age was 14 years (range 7-19). Five were diagnosed as TIN histopathologically, fourteen patients were diagnosed as clinically...
November 2015: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27629781/eosinophilic-tubulointerstitial-nephritis-on-treatment-with-isotretinoin
#9
Gulsah Kaya Aksoy, Mustafa Koyun, Bahar Akkaya, Elif Comak, Atilla Gemici, Sema Akman
: Drug-related acute tubulointerstitial nephritis is one of the most common causes of childhood acute renal failures which originate from kidneys. Sixteen-year old male patient with the history of isotretinoin use for the last 3 months was admitted with acute renal failure. Renal function parameters were measured as follows: blood urea nitrogen 21 mg/dL, serum creatinine 1.68 mg/dL, cystatin C 1.15 mg/L, and estimated glomerular filtration rate based on cystatin C 56.5 mL/min/1.73 m2...
December 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27594450/acute-interstitial-nephritis-in-t-cell-leukemia-in-a-pediatric-patient
#10
Erika Biro, Edit Szikszay, Petronella Pethő-Orosz, László Bigida, György Balla, Tamás Szabó
Acute lymphoid leukemia is the most frequently occurring malignancy in childhood, but acute tubulointerstitial nephritis with associated acute renal failure as the leading manifestation of leukemia is extremely rare. Only a few pediatric cases have been described in the literature. We present a surprising case in which physical examination and initial investigation were not typical for leukemia. Ultrasound showed only modest kidney enlargement while laboratory results indicated acute renal failure. Renal biopsy indicated tubulointerstitial nephritis, and subsequent steroid treatment led to sudden clinical improvement...
September 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27437289/synthetic-cannabinoid-induced-acute-tubulointerstitial-nephritis-and-uveitis-syndrome-a-case-report-and-review-of-literature
#11
Ayse Sinangil, Vedat Celik, Alev Kockar, Tevfik Ecder
Tubulointerstitial Nephritis with Uveitis (TINU) syndrome is a rarely seen syndrome. The interstitial nephritis may be with the concurrent uveitis and can also develop before or after uveitis. The syndrome can resolve after elimination of the culprit destructive factors, such as drugs, toxins and immune reaction. Synthetic cannabinoids have emerged as drugs of abuse with increasing popularity among young adults. Recent literature has documented reports of acute kidney injury in association with the use of synthetic cannabinoids; however, there is no report of TINU syndrome development secondary to using of synthetic cannabinoids...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27436034/rare-allergic-reaction-of-the-kidney-sitagliptin-induced-acute-tubulointerstitial-nephritis
#12
Ali A Alsaad, Sarah M Dhannoon, Sally-Ann L Pantin, Ivan E Porter
A 56-year-old man with a history of diabetes mellitus type-2 and stage-2 chronic kidney disease secondary to diabetic nephropathy presented with an acute deterioration of kidney function. Non-invasive work-up failed to reveal the underlying aetiology for the acute kidney failure. Kidney biopsy revealed acute tubulointerstitial nephritis (ATIN) which was attributed to sitagliptin use. Only few case reports have shown this correlation. Our aim is to alert physicians and other providers of the potential effect of sitagliptin to cause ATIN with this biopsy-proven case...
July 19, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27367994/clinicopathologic-characteristics-treatment-and-outcomes-of-tubulointerstitial-nephritis-and-uveitis-syndrome-in-adults-a-national-retrospective-strobe-compliant-study
#13
Mathieu Legendre, Hervé Devilliers, Laurent Perard, Matthieu Groh, Habdelamid Nefti, Bertrand Dussol, Salim Trad, Fatouma Touré, Sébastien Abad, Jean-Jacques Boffa, Luc Frimat, Stéphane Torner, Alexandre Seidowsky, Ziad André Massy, David Saadoun, Virginie Rieu, Yoland Schoindre, Emmanuel Heron, Thierry Frouget, Arnaud Lionet, François Glowacki, Laurent Arnaud, Christiane Mousson, Jean-François Besancenot, Jean-Michel Rebibou, Philip Bielefeld
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, defined by the association of idiopathic acute TINU. The aim of our work was to determine the characteristics of adult TINU syndrome in France, and to assess factors (including treatment) influencing medium-term prognosis.We conducted a nationwide study including 20 French hospitals. Clinical, laboratory, and renal histopathologic data of 41 biopsy-proven TINU syndromes were retrospectively collected. The patients were diagnosed between January 1, 1999 and December 1, 2015...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27282937/clinicopathological-features-of-acute-kidney-injury-associated-with-immune-checkpoint-inhibitors
#14
Frank B Cortazar, Kristen A Marrone, Megan L Troxell, Kenneth M Ralto, Melanie P Hoenig, Julie R Brahmer, Dung T Le, Evan J Lipson, Ilya G Glezerman, Jedd Wolchok, Lynn D Cornell, Paul Feldman, Michael B Stokes, Sarah A Zapata, F Stephen Hodi, Patrick A Ott, Michifumi Yamashita, David E Leaf
Immune checkpoint inhibitors (CPIs), monoclonal antibodies that target inhibitory receptors expressed on T cells, represent an emerging class of immunotherapy used in treating solid organ and hematologic malignancies. We describe the clinical and histologic features of 13 patients with CPI-induced acute kidney injury (AKI) who underwent kidney biopsy. Median time from initiation of a CPI to AKI was 91 (range, 21 to 245) days. Pyuria was present in 8 patients, and the median urine protein to creatinine ratio was 0...
September 2016: Kidney International
https://www.readbyqxmd.com/read/27274826/severe-acute-interstitial-nephritis-after-combination-immune-checkpoint-inhibitor-therapy-for-metastatic-melanoma
#15
Naoka Murakami, Thiago J Borges, Michifumi Yamashita, Leonardo V Riella
Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases including colitis, endocrinopathies and nephritis. Here, we report a case of a 75-year-old man with metastatic malignant melanoma treated with a combination of nivolumab (anti-PD1-antibody) and ipilimumab (anti-CTLA-4 antibody) who developed systemic rash along with severe acute tubulointerstitial nephritis after two doses of combination therapy...
June 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27181549/acute-tubulointerstitial-nephritis-associated-with-infliximab-in-a-patient-with-crohn-s-disease
#16
Mineto Ota, Hideyuki Iwai, Kaori Imai, Mari Kamiya, Yoko Yoshihashi-Nakazato, Nobuyuki Miyasaka, Hitoshi Kohsaka
We report the findings of a 46-year-old man, who presented with fever and renal dysfunction while undergoing treatment for Crohn's disease with infliximab (IFX). Remittent fever and renal dysfunction with urinary casts developed and lasted for 3 weeks without deterioration of Crohn's disease. Renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After the discontinuation of IFX, his fever and renal abnormalities resolved. We herein report the first known case of ATIN associated with IFX.
2016: Internal Medicine
https://www.readbyqxmd.com/read/27085555/dendritic-cells-in-renal-biopsies-of-patients-with-acute-tubulointerstitial-nephritis
#17
Mingyu Cheng, Xin Gu, Guillermo A Herrera
Dendritic cells (DCs) play a critical role in the regulation of the adaptive immune response and can be separated into 2 major subsets: myeloid (mDC) and plasmacytoid (pDC) DCs. Acute tubulointerstitial nephritis (ATIN) is a common cause of injury to renal tubules and interstitium resulting from the interplay of tubular cells and inflammatory cells and their products. However, the involvement of DCs in ATIN is still unknown. In this study, the participation and localization of myeloid (CD1c) and plasmacytoid (CD303) DC subsets in the biopsies from patients with ATIN (n=20), lupus nephritis (n=17, positive control), or minimal change disease (n=14, negative control) were investigated...
August 2016: Human Pathology
https://www.readbyqxmd.com/read/27069962/acute-tubulointerstitial-nephritis-drug-induced-acute-kidney-injury-an-experience-from-a-single-center-in-pakistan
#18
Rubina Naqvi, Muhammad Mubarak, Ejaz Ahmed, Fazal Akhtar, Anwar Naqvi, Adib Rizvi
INTRODUCTION: There is no information in literature specifically on the prevalence and clinicopathological characteristics of acute tubulointerstitial nephritis/drug induced acute kidney injury (AKI) from Pakistan. OBJECTIVES: We aim to report a series of cases from patients developing AKI after exposure to some medications or finding of interstitial nephritis on histopathology. PATIENTS AND METHODS: This is an observational study of patients identified as having AKI after exposure to medications...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27051251/a-case-report-of-a-middle-east-respiratory-syndrome-survivor-with-kidney-biopsy-results
#19
Ran-Hui Cha, Seung Hee Yang, Kyung Chul Moon, Joon-Sung Joh, Ji Yeon Lee, Hyoung-Shik Shin, Dong Ki Kim, Yon Su Kim
A 68-year old man diagnosed with Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) presented with multiple pneumonic infiltrations on his chest X-ray, and the patient was placed on a mechanical ventilator because of progressive respiratory failure. Urinary protein excretion steadily increased for a microalbumin to creatinine ratio of 538.4 mg/g Cr and a protein to creatinine ratio of 3,025.8 mg/g Cr. The isotope dilution mass spectrometry traceable serum creatinine level increased to 3.0 mg/dL. We performed a kidney biopsy 8 weeks after the onset of symptoms...
April 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27050722/clinicopathological-features-and-risk-factors-analysis-of-iga-nephropathy-associated-with-acute-kidney-injury
#20
Ling Zhang, Jianbo Li, Shicong Yang, Naya Huang, Qian Zhou, Qiongqiong Yang, Xueqing Yu
OBJECTIVE: The aim of this work is to investigate the distinctive clinicopathological characteristics of AKI in Chinese IgAN population and possible risk factors for AKI. METHODS: We performed a retrospective analysis of 1512 patients with biopsy-proven primary IgAN in the period 2006 through 2011 in The First Affiliated Hospital of Sun Yat-sen University. AKI was defined as 2012 KDIGO (Kidney Diseases: Improving Global Outcomes) criteria, and the patients were divided into AKI group (n = 145) and non-AKI group (n = 1367)...
June 2016: Renal Failure
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