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https://www.readbyqxmd.com/read/29932873/validity-of-clinical-small-fiber-sensory-testing-to-detect-small-nerve-fiber-degeneration
#1
Colette Ridehalgh, Oliver P Sandy-Hindmarch, Aninna B Schmid
Study Design Prospective, cross-sectional diagnostic accuracy study. Background Small nerve fiber degeneration (SFD) commonly occurs in patients with peripheral neuropathies, resulting in deterioration in nerve function. Currently, the gold standard to identify SFD is through skin biopsies. Simple clinical tests aim to identify SFD, but their validity remains unknown. Objectives To examine the validity of clinical tests to assess SFD using carpal tunnel syndrome (CTS) as a model system. Methods 107 participants (22 healthy, 85 with CTS) underwent pinprick testing over the index finger, and had cold and warm detection thresholds taken (CDT, WDT) using quantitative sensory testing (QST)...
June 22, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29932203/sequential-evaporation-of-water-molecules-from-protonated-water-clusters-measurement-of-the-velocity-distributions-of-the-evaporated-molecules-and-statistical-analysis
#2
F Berthias, L Feketeová, H Abdoul-Carime, F Calvo, B Farizon, M Farizon, T D Märk
Velocity distributions of neutral water molecules evaporated after collision induced dissociation of protonated water clusters H+(H2O)n≤10 were measured using the combined correlated ion and neutral fragment time-of-flight (COINTOF) and velocity map imaging (VMI) techniques. As observed previously, all measured velocity distributions exhibit two contributions, with a low velocity part identified by statistical molecular dynamics (SMD) simulations as events obeying the Maxwell-Boltzmann statistics and a high velocity contribution corresponding to non-ergodic events in which energy redistribution is incomplete...
June 22, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29932194/quality-assessment-of-penthorum-chinense-pursh-through-multicomponent-qualification-and-fingerprint-chemometric-and-antihepatocarcinoma-analyses
#3
Zong-Liang Sun, Yu-Zhen Zhang, Feng Zhang, Jia-Wei Zhang, Guo-Can Zheng, Ling Tan, Chong-Zhi Wang, Lian-Di Zhou, Qi-Hui Zhang, Chun-Su Yuan
An efficient method combined with fingerprint and chemometric analyses was developed to evaluate the quality of the traditional Chinese medicine plant Penthorum chinense Pursh. Nine samples were collected from different regions during different harvest periods, and 17 components in the form of extracts were simultaneously examined to assess quality by using high-performance liquid chromatography. The hepatoprotective effects of components were investigated by assessing the inhibition of SMMC-7721 cell growth...
June 22, 2018: Food & Function
https://www.readbyqxmd.com/read/29931140/exposures-to-volatile-organic-compounds-among-healthcare-workers-modeling-the-effects-of-cleaning-tasks-and-product-use
#4
Feng-Chiao Su, Melissa C Friesen, Aleksandr B Stefaniak, Paul K Henneberger, Ryan F LeBouf, Marcia L Stanton, Xiaoming Liang, Michael Humann, M Abbas Virji
Objectives: Use of cleaning and disinfecting products is associated with work-related asthma among healthcare workers, but the specific levels and factors that affect exposures remain unclear. The objective of this study was to evaluate the determinants of selected volatile organic compound (VOC) exposures in healthcare settings. Methods: Personal and mobile-area air measurements (n = 143) from 100 healthcare workers at four hospitals were used to model the determinants of ethanol, acetone, 2-propanol, d-limonene, α-pinene, and chloroform exposures...
June 21, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29930527/profiles-of-motor-laterality-in-young-athletes-performance-of-complex-movements-merging-the-motorlat-and-pathoops-tools
#5
Marta Castañer, Juan Andueza, Raúl Hileno, Silvia Puigarnau, Queralt Prat, Oleguer Camerino
Laterality is a key aspect of the analysis of basic and specific motor skills. It is relevant to sports because it involves motor laterality profiles beyond left-right preference and spatial orientation of the body. The aim of this study was to obtain the laterality profiles of young athletes, taking into account the synergies between the support and precision functions of limbs and body parts in the performance of complex motor skills. We applied two instruments: (a) MOTORLAT, a motor laterality inventory comprising 30 items of basic, specific, and combined motor skills, and (b) the Precision and Agility Tapping over Hoops (PATHoops) task, in which participants had to perform a path by stepping in each of 14 hoops arranged on the floor, allowing the observation of their feet, left-right preference and spatial orientation...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29930418/-research-on-the-reliability-and-validity-of-postural-workload-assessment-method-and-the-relation-to-work-related-musculoskeletal-disorders-of-workers
#6
D L Qin, X N Jin, S J Wang, J J Wang, N Mamat, F J Wang, Y Wang, Z A Shen, L G Sheng, M Forsman, L Y Yang, S Wang, Z B Zhang, L H He
OBJECTIVE: To form a new assessment method to evaluate postural workload comprehensively analyzing the dynamic and static postural workload for workers during their work process to analyze the reliability and validity, and to study the relation between workers' postural workload and work-related musculoskeletal disorders (WMSDs). METHODS: In the study, 844 workers from electronic and railway vehicle manufacturing factories were selected as subjects investigated by using the China Musculoskeletal Questionnaire (CMQ) to form the postural workload comprehensive assessment method...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29930415/-relationship-between-sugary-drinks-and-diabetes-of-adults-in-wuhai-city
#7
H Z He, T Zhang, J Zhou, D P Wang, H J Wang, Y Song, Z Zhu, P Y Wang, A P Liu
OBJECTIVE: To explore the relationship between sugary drinks and diabetes of adults in Wuhai city. METHODS: A multiple stage stratified cluster sampling was conducted on 8 131 residents who were between 35 and 79 years by cross-sectional study in Wuhai city. Questionnaires, physical measurements and laboratory tests were used to collect information on demographic information, dietary behavior, health status, blood glucose indicators. Besides, other covariate information was also collected by these ways...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29930409/-association-between-speed-and-endurance-performance-with-sleep-duration-in-children-and-adolescents
#8
T Q Chen, B Dong, W J Zhang, D S Gao, Y H Dong, J Ma, Y H Ma
OBJECTIVE: To analyze the association between sleep duration and athletic performance, and provide scientific basis to improve the 50 m and endurance performance in children and adolescents. METHODS: All the 119 462 subjects aged 9-15 years in both genders were sampled from 2014 National Physical Fitness and Health Surveillance by using stratified random cluster sampling method, to measure the height, weight, 50 meters and endurance performance and investigate sleep duration with questionnaire...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29930351/author-correction-a-massive-core-for-a-cluster-of-galaxies-at-a-redshift-of-4-3
#9
T B Miller, S C Chapman, M Aravena, M L N Ashby, C C Hayward, J D Vieira, A Weiß, A Babul, M Béthermin, C M Bradford, M Brodwin, J E Carlstrom, Chian-Chou Chen, D J M Cunningham, C De Breuck, A H Gonzalez, T R Greve, J Harnett, Y Hezaveh, K Lacaille, K C Litke, J Ma, M Malkan, D P Marrone, W Morningstar, E J Murphy, D Narayanan, E Pass, R Perry, K A Phadke, D Rennehan, K M Rotermund, J Simpson, J S Spilker, J Sreevani, A A Stark, M L Strandet, A L Strom
Change history: In this Letter, the Acknowledgements section should have included the following sentence: "The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc.". This omission has been corrected online.
June 21, 2018: Nature
https://www.readbyqxmd.com/read/29930035/complete-genome-sequences-of-honestabe-anthony-and-taffo16-three-cluster-c-bacillus-cereus-group-bacteriophages
#10
Martin Lee, Kayla M Puglisi, Ivan Erill, Steven M Caruso
Three cluster C Myoviridae bacteriophages that infect Bacillus cereus group bacteria were isolated from soil collected in the mid-Atlantic region using B. thuringiensis subsp. kurstaki as a host. Bacillus phages HonestAbe, Anthony, and Taffo16 each shared 90% or higher average nucleotide identities within their subclusters.
June 21, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29929360/-clostridium-botulinum-spores-in-polish-honey-samples
#11
Tomasz Grenda, Magdalena Grabczak, Zbigniew Sieradzki, Krzysztof Kwiatek, Krystyna Pohorecka, Marta Skubida, Andrzej Bober
The aim of this study was examination of 240 multifloral honey samples collected from Polish apiaries for C. botulinum occurrence. Honey was collected directly from apiaries after the extraction process. Samples were inoculated by using the dilution and centrifugation (DC) method. Suspected isolates were examined by using mouse bioassay, PCR and real-time PCR methods. Clostridium botulinum type A and B strains were detected in 5 (2%) of 240 examined honey samples. Strains were also detected which were phenotypically similar to C...
June 21, 2018: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29928512/identification-of-an-immune-gene-expression-signature-associated-with-favorable-clinical-features-in-treg-enriched-patient-tumor-samples
#12
Kevin B Givechian, Kamil Wnuk, Chad Garner, Stephen Benz, Hermes Garban, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong
Immune heterogeneity within the tumor microenvironment undoubtedly adds several layers of complexity to our understanding of drug sensitivity and patient prognosis across various cancer types. Within the tumor microenvironment, immunogenicity is a favorable clinical feature in part driven by the antitumor activity of CD8+ T cells. However, tumors often inhibit this antitumor activity by exploiting the suppressive function of regulatory T cells (Tregs), thus suppressing the adaptive immune response. Despite the seemingly intuitive immunosuppressive biology of Tregs, prognostic studies have produced contradictory results regarding the relationship between Treg enrichment and survival...
2018: NPJ Genomic Medicine
https://www.readbyqxmd.com/read/29928042/molecular-characterization-and-antimicrobial-susceptibility-pattern-of-streptococcus-agalactiae-isolated-from-clinical-mastitis-in-dairy-cattle
#13
Tiago Tomazi, Antonio Francisco de Souza Filho, Marcos Bryan Heinemann, Marcos Veiga Dos Santos
The objectives of this study were to: (a) genotypically characterize Streptococcus agalactiae isolates recovered from clinical mastitis (CM) cases in dairy cows and, (b) determine the association of antimicrobial susceptibility (AMS) and genotypes of Strep. agalactiae clustered according to the genetic similarity. A total of 89 Strep. agalactiae isolates recovered from bovine CM were genotyped using random amplified polymorphic DNA (RAPD) analysis. In addition, the AMS of the isolates was determined using a commercial broth microdilution test composed of 10 antimicrobials (penicillin, ampicillin, oxacillin, cephalothin, ceftiofur, penicillin/novobiocin, erythromycin, pirlimycin, tetracycline, and sulfadimethoxine)...
2018: PloS One
https://www.readbyqxmd.com/read/29927889/accentuated-eccentric-loading-and-cluster-set-configurations-in-the-back-squat-a-kinetic-and-kinematic-analysis
#14
John P Wagle, Aaron J Cunanan, Kevin M Carroll, Matt L Sams, Alexander Wetmore, Garett E Bingham, Christopher B Taber, Brad H DeWeese, Kimitake Sato, Charles A Stuart, Michael H Stone
Wagle, JP, Cunanan, AJ, Carroll, KM, Sams, ML, Wetmore, A, Bingham, GE, Taber, CB, DeWeese, BH, Sato, K, Stuart, CA, and Stone, MH. Accentuated eccentric loading and cluster set configurations in the back squat: a kinetic and kinematic analysis. J Strength Cond Res XX(X): 000-000, 2018-This study examined the kinetic and kinematic differences between accentuated eccentric loading (AEL) and cluster sets in trained male subjects (age = 26.1 ± 4.1 years, height = 183.5 ± 4.3 cm, body mass = 92.5 ± 10.5 kg, and back squat to body mass ratio = 1...
June 20, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29927834/role-of-thrombospondin-1-and-nuclear-factor-kappa-b-signaling-pathways-in-anti-angiogenesis-of-infantile-hemangioma
#15
Weili Xu, Suolin Li, Fengxue Yu, Yongting Zhang, Xiaofeng Yang, Wenting An, Wenbo Wang, Chi Sun
BACKGROUND: Propranolol (PRO) is the first-line drug for infantile hemangioma treatment. However, its mechanism of action remains unclear. Nuclear factor-kappa B (NF-κB) is highly expressed in tumors, directly or indirectly promoting angiogenesis. Thrombospondin-1 (TSP-1) is the most important anti-angiogenesis protein in vivo. These proteins mediate signaling pathways, probably playing an important role in hemangioma treatment. This study explored the synergistic regulation of TSP-1 and NF-κB signaling pathways in the treatment of hemangioma with PRO...
June 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29927724/contribution-of-healthy-chickens-to-antimicrobial-resistant-escherichia-coli-associated-with-human-extraintestinal-infections-in-egypt
#16
Hazem H Ramadan, Charlene R Jackson, Samaa A Taha, Amira A Moawad, John B Barrett, Tiffanie A Woodley
BACKGROUND: Chickens are considered potential reservoirs for human extraintestinal infections with pathogenic Escherichia coli. However, information about genetic relatedness between E. coli from healthy chickens and human patients is still limited. METHODS AND RESULTS: In this study, clinical samples from patients with extraintestinal infections and healthy broiler chickens were collected from geographically related locations in Egypt during the 2nd half of 2015...
June 21, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29927439/-the-informative-value-of-various-methods-for-identifying-acid-fast-bacilli-in-relation-to-the-degree-of-tuberculosis-process-activity
#17
V A Zinserling, M M Agapov, A N Orlov
Carbol fuchsin (Ziehl-Neelsen) staining is a major method used since the late nineteenth century to detect Mycobacterium tuberculosis in the tissues. At the same time, the number of mycobacteria does not frequently show a clinical and morphological correspondence to the activity of the infectious process. OBJECTIVE: To reveal the morphological characteristics of Mycobacterium tuberculosis in patients with long-lasting tuberculosis. MATERIAL AND METHODS: Twenty-four autopsies of verified fibrous-cavernous tuberculosis were examined...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29927106/pathogenic-citrulline-multispecific-b-cell-receptor-clades-in-rheumatoid-arthritis
#18
Philip J Titcombe, Gustaf Wigerblade, Natalie Sippl, Na Zhang, Anna K Shmagel, Peter Sahlström, Yue Zhang, Laura O Barsness, Yogita Ghodke-Puranik, Azar Baharpoor, Monika Hansson, Lena Israelsson, Karl Skriner, Timothy B Niewold, Lars Klareskog, Camilla I Svensson, Khaled Amara, Vivianne Malmström, Daniel L Mueller
OBJECTIVE: Anti-citrullinated protein antibodies (ACPA) have proven highly useful as biomarkers in rheumatoid arthritis (RA). However, the composition and functionality of the associated autoreactive B cell repertoire have not been directly assessed. We aimed to selectively investigate citrullinated autoantigen-specific B cell receptors (BCRs) involved in RA and initiate studies on their pathogenicity. METHODS: A University of Minnesota ACPA+ RA cohort (n = 89 subjects) provided blood samples...
June 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29926537/identification-and-characterization-of-new-muscodor-endophytes-from-gramineous-plants-in-xishuangbanna-china
#19
Li-Juan Mao, Jia-Jie Chen, Chen-Yang Xia, Xiao-Xiao Feng, De-Dong Kong, Zhen-Yu Qi, Feng Liu, Dian Chen, Fu-Cheng Lin, Chu-Long Zhang
The endophytic fungi Muscodor spp. produce volatile organic compounds (VOCs) which can inhibit and even kill pathogenic fungi, bacteria, and nematodes. Nine endophytic fungal strains, isolated from the shoots of gramineous plants including Arthraxon hispidus, Eleusine indica, Oplismenus undulatifolius, and Oryza granulata, were identified as Muscodor through phylogenetic analysis of the internal transcribed spacer. Through an SPSS K-means cluster analysis, the nine Muscodor strains were divided into four groups based on the antifungal activities of the VOCs produced by these fungi determined by a two-section confrontation test...
June 21, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29926224/identification-characterization-and-expression-analysis-of-auxin-response-factor-arf-gene-family-in-brachypodium-distachyon
#20
Xiaojian Zhou, Xiaozhu Wu, Tongjian Li, Mingliang Jia, Xinshen Liu, Yulan Zou, Zixia Liu, Feng Wen
Auxin response factors (ARFs) are one type of essential family of transcription factors that bind with auxin response elements (AuxRE), and play vital roles in variety of plant development and physiological processes. Brachypodium distachyon, related to the major cereal grain species, were recently developed to be a good model organism for functional genomics research. So far, genome-wide overview of the ARF gene family in B. distachyon was not available. Here, a systemic analysis of ARF gene family members in B...
June 20, 2018: Functional & Integrative Genomics
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