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https://www.readbyqxmd.com/read/28647969/-knowledge-attitude-and-practice-to-chronic-diseases-and-associated-influencing-factors-in-uygur-population-in-kashgar-area-of-xinjiang-uygur-autonomous-region
#1
Z B Zhang, Z X Xue, M M Ma, Y H Li, D M Luo, X L Song, X F Chao, G Wang, Nurmamat Nazibam, Bawudun Ayxamgul, Mahat Sulayman, X J Wu, Z Y Zhou, B S Sun, Y Z Wang, M Wang
Objective: To investigate the knowledge, attitude and practice (KAP) to chronic diseases and associated influencing factors in Uygur adults in Kashgar of southern Xinjiang, and provide basic information for developing ethnic specific prevention and control strategies for chronic diseases. Methods: With stratified cluster random sampling, investigations, including questionnaire survey, physical examination and laboratory tests were performed among local residents who were aged ≥18 years and selected in Shufu county in southern Xinjiang...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28647968/-prevalence-of-hypertension-and-risk-factors-in-uygur-population-in-kashgar-area-of-xinjiang-uygur-autonomous-region
#2
Z B Zhang, Z X Xue, H Y Chen, T M Wang, Y H Li, X F Chao, G Wang, D M Luo, X J Wu, Nurmamat Nazibam, Bawudun Ayxamgul, Elyas Gulbahar, Z Y Zhou, B S Sun, Y Z Wang, M Wang
Objective: To investigate the prevalence of hypertension and risk factors in Uygur adults in Kashgar of Xinjiang. Methods: A total of 4 748 Uygur adults aged ≥18 years selected through cluster random sampling in Shufu county of Kashgar prefecture were surveyed by means of questionnaire survey, physical examination and laboratory test. The prevalence, awareness, treatment and control rate of hypertension of different groups were calculated and risk factors of hypertension was analyzed by using non-conditional logistic regression model...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28647967/-prevalence-of-dyslipidemia-and-normal-blood-lipids-level-in-uygur-population-in-kashgar-area-of-xinjiang-uygur-autonomous-region
#3
Z B Zhang, Z X Xue, X J Wu, T M Wang, Y H Li, X L Song, X F Chao, G Wang, Nurmamat Nazibam, Bawudun Ayxamgul, Elyas Gulbahar, Z Y Zhou, B S Sun, Y Z Wang, M Wang
Objective: To understand the prevalence of dyslipidemia and normal blood lipids level in Uygur diabetes patients in Kashgar prefecture in southern area of Xinjiang. Methods: A total of 5 078 local residents aged ≥18 years (42.56% were men) selected through cluster random sampling in Kashgar were surveyed by means of questionnaire survey, physical examination and laboratory test, and 521 diabetes patients were screened. Results: The overall prevalence of dyslipidemia in diabetes patients was 59.50% (310/521) with adjusted rate as 49...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28647966/-prevalence-of-diabetes-mellitus-and-associated-risk-factors-in-uygur-population-in-kashgar-area-of-xinjiang-uygur-autonomous-region
#4
Z B Zhang, Z X Xue, H Wang, T M Wang, Y H Li, X L Song, X F Chao, G Wang, X J Wu, Nurmamat Nazibam, Bawudun Ayxamgul, Elyas Gulbahar, Z Y Zhou, B S Sun, Y Z Wang, M Wang
Objective: To investigate the epidemiologic characteristics of diabetes mellitus (DM) in Uygur residents in Kashgar of Xinjiang. Methods: The survey was conducted among the Uygur residents aged ≥18 years selected through stratified cluster sampling in Kashgar by means of questionnaire survey, physical examination and basic laboratory test. The prevalence of different groups were calculated and risk factors of DM was analyzed by logistic vegression model. Results: A total of 4 608 adults were surveyed. The prevalence of DM was 11...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28647304/phylogenies-of-symbiotic-genes-of-bradyrhizobium-symbionts-of-legumes-of-economic-and-environmental-importance-in-brazil-support-the-definition-of-the-new-symbiovars-pachyrhizi-and-sojae
#5
Jakeline Renata Marçon Delamuta, Pâmela Menna, Renan Augusto Ribeiro, Mariangela Hungria
Bradyrhizobium comprises most tropical symbiotic nitrogen-fixing strains, but the correlation between symbiotic and core genes with host specificity is still unclear. In this study, the phylogenies of the nodY/K and nifH genes of 45 Bradyrhizobium strains isolated from legumes of economic and environmental importance in Brazil (Arachis hypogaea, Acacia auriculiformis, Glycine max, Lespedeza striata, Lupinus albus, Stylosanthes sp. and Vigna unguiculata) were compared to 16S rRNA gene phylogeny and genetic diversity by rep-PCR...
June 7, 2017: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/28646792/bacterial-profile-in-human-atherosclerotic-plaques
#6
Annika Lindskog Jonsson, Frida Fåk Hållenius, Rozita Akrami, Elias Johansson, Per Wester, Conny Arnerlöv, Fredrik Bäckhed, Göran Bergström
BACKGROUND AND AIMS: Several studies have confirmed the presence of bacterial DNA in atherosclerotic plaques, but its contribution to plaque stability and vulnerability is unclear. In this study, we investigated whether the bacterial plaque-profile differed between patients that were asymptomatic or symptomatic and whether there were local differences in the microbial composition within the plaque. METHODS: Plaques were removed by endarterectomy from asymptomatic and symptomatic patients and divided into three different regions known to show different histological vulnerability: A, upstream of the maximum stenosis; B, site for maximum stenosis; C, downstream of the maximum stenosis...
June 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28646206/crispr-cas9-mediated-genome-editing-via-postnatal-administration-of-aav-vector-cures-haemophilia-b-mice
#7
Tsukasa Ohmori, Yasumitsu Nagao, Hiroaki Mizukami, Asuka Sakata, Shin-Ichi Muramatsu, Keiya Ozawa, Shin-Ichi Tominaga, Yutaka Hanazono, Satoshi Nishimura, Osamu Nureki, Yoichi Sakata
Haemophilia B, a congenital haemorrhagic disease caused by mutations in coagulation factor IX gene (F9), is considered an appropriate target for genome editing technology. Here, we describe treatment strategies for haemophilia B mice using the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system. Administration of adeno-associated virus (AAV) 8 vector harbouring Staphylococcus aureus Cas9 (SaCas9) and single guide RNA (sgRNA) to wild-type adult mice induced a double-strand break (DSB) at the target site of F9 in hepatocytes, sufficiently developing haemophilia B...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646116/tonic-b-cell-receptor-signaling-in-diffuse-large-b-cell-lymphoma
#8
Ondrej Havranek, Jingda Xu, Stefan Köhrer, Zhiqiang Wang, Lisa Becker, Justin M Comer, Jared Henderson, Wencai Ma, John Man Chun Ma, Jason R Westin, Dipanjan Ghosh, Nicholas Shinners, Luhong Sun, Allen F Yi, Anusha R Karri, Jan A Burger, Tomasz Zal, R Eric Davis
We used CRISPR/Cas9-mediated genomic modification to investigate B-cell receptor (BCR) signaling in cell lines of diffuse large B-cell lymphoma (DLBCL). Three manipulations that altered BCR genes without affecting surface BCR levels showed that BCR signaling differs between the germinal center B-cell (GCB) subtype, which is insensitive to BTK inhibition by ibrutinib, and the activated B-cell (ABC) subtype. Replacing antigen-binding BCR regions had no effect on BCR signaling in GCB-DLBCL lines, reflecting this subtype's exclusive use of tonic BCR signaling...
June 23, 2017: Blood
https://www.readbyqxmd.com/read/28646111/a-bacillus-paralicheniformis-iron-containing-urease-reduces-urea-concentrations-in-rice-wine
#9
Qingtao Liu, Yuqi Chen, Minglai Yuan, Guocheng Du, Jian Chen, Zhen Kang
Urease, as a nickel-containing metalloenzyme, was the first enzyme to be crystallized, and it has a prominent position in the history of biochemistry. In the present study, we identified a nickel urease gene cluster, ureABCEFGDH, from Bacillus paralicheniformis ATCC 9945a and characterized it in Escherichia coli Enzymatic assays demonstrate that this oxygen-stable urease is also an iron-containing acid urease. UreH heterologous expression assays suggest that this accessory protein is involved in transmembrane transportation of nickel and iron ions...
June 23, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28645869/real-time-changes-in-brain-activity-during-sacral-neuromodulation-for-overactive-bladder
#10
Bradley C Gill, Javier Pizarro Berdichevsky, Pallab K Bhattacharyya, Thaddeus S Brink, Brian K Marks, Adrienne Quirouet, Sandip P Vasavada, Stephen E Jones, Howard B Goldman
PURPOSE: To use functional magnetic resonance imaging(fMRI) for identifying changes in brain activity during sacral neuromodulation(SNM) in women with overactive bladder(OAB) who were responsive to therapy. MATERIALS AND METHODS: Women with non-neurogenic refractory OAB who responded to SNM, had a stable program for at least 3 months, with no subsequent OAB treatment were recruited. Enrolled patients completed pre-fMRI validated symptom and quality of life instruments...
June 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28645708/identification-of-major-routes-of-hiv-transmission-throughout-mesoamerica
#11
Antoine Chaillon, Santiago Avila-Ríos, Joel O Wertheim, Ann Dennis, Claudia García-Morales, Daniela Tapia-Trejo, Carlos Mejía-Villatoro, Juan M Pascale, Guillermo Porras-Cortés, Carlos J Quant-Durán, Ivette Lorenzana, Rita I Meza, Elsa Y Palou, Marvin Manzanero, Rolando A Cedillos, Gustavo Reyes-Terán, Sanjay R Mehta
BACKGROUND: Migration and travel are major drivers of the spread of infectious diseases. Geographic proximity and a common language facilitate travel and migration in Mesoamerica, which in turn could affect the spread of HIV in the region. METHODS: 6092 HIV-1 subtype B partial pol sequences sampled from unique antiretroviral treatment-naïve individuals from Mexico (40.7%), Guatemala (24.4%), Honduras (19%), Panama (8.2%), Nicaragua (5.5%), Belize (1.4%), and El Salvador (0...
June 20, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28645076/does-reflective-functioning-mediate-the-relationship-between-attachment-and-personality
#12
Maria Paola Nazzaro, Tommaso Boldrini, Annalisa Tanzilli, Laura Muzi, Guido Giovanardi, Vittorio Lingiardi
Mentalization, operationalized as reflective functioning (RF), can play a crucial role in the psychological mechanisms underlying personality functioning. This study aimed to: (a) study the association between RF, personality disorders (cluster level) and functioning; (b) investigate whether RF and personality functioning are influenced by (secure vs. insecure) attachment; and (c) explore the potential mediating effect of RF on the relationship between attachment and personality functioning. The Shedler-Westen Assessment Procedure (SWAP-200) was used to assess personality disorders and levels of psychological functioning in a clinical sample (N = 88)...
June 15, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28644612/suppressing-isomerization-of-phosphine-protected-au9-cluster-by-bond-stiffening-induced-by-a-single-pd-atom-substitution
#13
Seiji Yamazoe, Shota Matsuo, Satoru Muramatsu, Shinjiro Takano, Kiyofumi Nitta, Tatsuya Tsukuda
The fluxional nature of small gold clusters has been exemplified by reversible isomerization between [Au9(PPh3)8](3+) with a crown motif (Au9(C)) and that with a butterfly motif (Au9(B)) induced by association and dissociation with compact counteranions (NO3(-), Cl(-)). However, structural isomerization was suppressed by substitution of the central Au atom of the Au9 core in [Au9(PPh3)8](3+) with a Pd atom: [PdAu8(PPh3)8](2+) with a crown motif (PdAu8(C)) did not isomerize to that with a butterfly motif (PdAu8(B)) upon association with the counteranions...
June 23, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28644507/intrachromosomal-karyotype-asymmetry-in-orchidaceae
#14
Enoque Medeiros-Neto, Felipe Nollet, Ana Paula Moraes, Leonardo P Felix
The asymmetry indexes have helped cytotaxonomists to interpret and classify plant karyotypes for species delimitation efforts. However, there is no consensus about the best method to calculate the intrachromosomal asymmetry. The present study aimed to compare different intrachromosomal asymmetry indexes in order to indicate which are more efficient for the estimation of asymmetry in different groups of orchids. Besides, we aimed to compare our results with the Orchidaceae phylogenetic proposal to test the hypothesis of Stebbins (1971)...
June 22, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28644475/post-translational-modification-of-ribosomally-synthesized-peptides-by-a-radical-sam-epimerase-in-bacillus-subtilis
#15
Alhosna Benjdia, Alain Guillot, Pauline Ruffié, Jérôme Leprince, Olivier Berteau
Ribosomally synthesized peptides are built out of L-amino acids, whereas D-amino acids are generally the hallmark of non-ribosomal synthetic processes. Here we show that the model bacterium Bacillus subtilis is able to produce a novel type of ribosomally synthesized and post-translationally modified peptide that contains D-amino acids, and which we propose to call epipeptides. We demonstrate that a two [4Fe-4S]-cluster radical S-adenosyl-L-methionine (SAM) enzyme converts L-amino acids into their D-counterparts by catalysing Cα-hydrogen-atom abstraction and using a critical cysteine residue as the hydrogen-atom donor...
July 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28644379/physical-forces-may-cause-the-hoxd-gene-cluster-elongation
#16
Spyros Papageorgiou
Hox gene collinearity was discovered be Edward B. Lewis in 1978. It consists of the Hox1, Hox2, Hox3 ordering of the Hox genes in the chromosome from the telomeric to the centromeric side of the chromosome. Surprisingly, the spatial activation of the Hox genes in the ontogenetic units of the embryo follows the same ordering along the anterior-posterior embryonic axis. The chromosome microscale differs from the embryo macroscale by 3 to 4 orders of magnitude. The traditional biomolecular mechanisms are not adequate to comprise phenomena at so divergent spatial domains...
June 23, 2017: Biology
https://www.readbyqxmd.com/read/28644159/investigation-of-the-rosenbaum-concussion-knowledge-and-attitudes-survey-in-collegiate-athletes
#17
Erin B Chapman, Alan Nasypany, Jim May, Timothy Henry, Chris Hummel, Hyung-Pil Jun
OBJECTIVE: The purpose of this study is to determine whether the Rosenbaum Concussion Knowledge and Attitudes Survey (RoCKAS) is an appropriate outcome measure to assess knowledge and attitudes toward concussion in collegiate student-athletes as determined through validity and reliability testing. STUDY DESIGN: Convenience study. SETTING: The researcher recruited all athletic teams at a Division III National Collegiate Athletic Association institution...
June 14, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28642745/structure-of-o-antigen-and-hybrid-biosynthetic-locus-in-burkholderia-cenocepacia-clonal-variants-recovered-from-a-cystic-fibrosis-patient
#18
A A Hassan, Rita F Maldonado, Sandra C Dos Santos, Flaviana Di Lorenzo, Alba Silipo, Carla P Coutinho, Vaughn S Cooper, Antonio Molinaro, Miguel A Valvano, Isabel Sá-Correia
Burkholderia cenocepacia is an opportunistic pathogen associated with chronic lung infections and increased risk of death in patients with cystic fibrosis (CF). In this work, we investigated the lipopolysaccharide (LPS) of clinical variants of B. cenocepacia that were collected from a CF patient over a period of 3.5 years, from the onset of infection until death by necrotizing pneumonia (cepacia syndrome). We report the chemical structure of the LPS molecule of various sequential isolates and the identification of a novel hybrid O-antigen (OAg) biosynthetic cluster...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28642461/the-ca19-9-and-sialyl-tra-antigens-define-separate-subpopulations-of-pancreatic-cancer-cells
#19
Daniel Barnett, Ying Liu, Katie Partyka, Ying Huang, Huiyuan Tang, Galen Hostetter, Randall E Brand, Aatur D Singhi, Richard R Drake, Brian B Haab
Molecular markers to detect subtypes of cancer cells could facilitate more effective treatment. We recently identified a carbohydrate antigen, named sTRA, that is as accurate a serological biomarker of pancreatic cancer as the cancer antigen CA19-9. We hypothesized that the cancer cells producing sTRA are a different subpopulation than those producing CA19-9. The sTRA glycan was significantly elevated in tumor tissue relative to adjacent pancreatic tissue in 3 separate tissue microarrays covering 38 patients...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642380/complete-genome-sequence-of-bacillus-paralicheniformis-mdjk30-a-plant-growth-promoting-rhizobacterium-with-antifungal-activity
#20
Yun Wang, Hu Liu, Kai Liu, Chengqiang Wang, Hailin Ma, Yuhuan Li, Qihui Hou, Fangchun Liu, Tongrui Zhang, Haide Wang, Beibei Wang, Jinjin Ma, Ruofei Ge, Baochao Xu, Gan Yao, Wenfeng Xu, Lingchao Fan, Yanqin Ding, Binghai Du
Bacillus paralicheniformis MDJK30 was isolated from the rhizosphere of a peony. It could control the pathogen of peony root rot. Here, we report the complete genome sequence of B. paralicheniformis MDJK30. Eleven secondary metabolism gene clusters were predicted.
June 22, 2017: Genome Announcements
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