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Ambrosio Renato

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https://www.readbyqxmd.com/read/28681902/integration-of-scheimpflug-based-corneal-tomography-and-biomechanical-assessments-for-enhancing-ectasia-detection
#1
Renato Ambrósio, Bernardo T Lopes, Fernando Faria-Correia, Marcella Q Salomão, Jens Bühren, Cynthia J Roberts, Ahmed Elsheikh, Riccardo Vinciguerra, Paolo Vinciguerra
PURPOSE: To present the Tomographic and Biomechanical Index (TBI), which combines Scheimpflugbased corneal tomography and biomechanics for enhancing ectasia detection. METHODS: Patients from different continents were retrospectively studied. The normal group included 1 eye randomly selected from 480 patients with normal corneas and the keratoconus group included 1 eye randomly selected from 204 patients with keratoconus. There were two groups: 72 ectatic eyes with no surgery from 94 patients with very asymmetric ectasia (VAE-E group) and the fellow eyes of these patients with normal topography (VAE-NT group)...
July 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28676837/repeatability-and-reproducibility-of-intraocular-pressure-and-dynamic-corneal-response-parameters-assessed-by-the-corvis-st
#2
Bernardo T Lopes, Cynthia J Roberts, Ahmed Elsheikh, Riccardo Vinciguerra, Paolo Vinciguerra, Sven Reisdorf, Stefanie Berger, Robert Koprowski, Renato Ambrósio
PURPOSE: To assess the repeatability and reproducibility of dynamic corneal response parameters measured by the Corvis ST (Oculus, Wetzlar, Germany). METHODS: One eye randomly selected from 32 healthy volunteers was examined by the Corvis ST. Three different devices were used in an alternated random order for taking three measurements at each device in each subject. Standard intraocular pressure (IOP), the biomechanical-compensated IOP (bIOP), and DCR parameters were evaluated...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28586501/biomechanical-characterization-of-subclinical-keratoconus-without-topographic-or-tomographic-abnormalities
#3
Riccardo Vinciguerra, Renato Ambrósio, Cynthia J Roberts, Claudio Azzolini, Paolo Vinciguerra
PURPOSE: To present a case series of patients with subclinical keratoconus with normal topometric (anterior curvature) and tomographic findings in one eye who showed abnormalities detected by Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany) in vivo biomechanical assessment. METHODS: All patients had a complete ophthalmic examination, including the Corvis ST biomechanical measurements, optical tomography, and pachymetry with Pentacam (Oculus Optikgeräte GmbH), and Placido-based topography with either the Nidek (OPD III Nidek, Gamagori, Japan) or CSO platform (Costruzione Strumenti Oftalmici, Florence, Italy)...
June 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28550347/correlation-between-different-scheimpflug-based-lens-densitometry-analysis-and-effective-phacoemulsification-time-in-mild-nuclear-cataracts
#4
Fernando Faria-Correia, Bernardo Lopes, Tiago Monteiro, Nuno Franqueira, Renato Ambrósio
PURPOSE: To assess the correlations between preoperative Scheimpflug-based lens densitometry and effective phacoemulsification time (EPT) in age-related nuclear cataracts. DESIGN: Retrospective consecutive study. METHODS: The setting was the Ophthalmology Department, Hospital de Braga, Portugal. The study population included 50 eyes (42 patients) with age-related nuclear cataracts submitted to uneventful phacoemulsification surgery. Different analysis methods of Scheimpflug-based lens densitometry were performed: Pentacam Nucleus Staging (PNS) score with an ordinal scale from 0 to 5 and three-dimensional (3D), linear and region of interest (ROI) methods, which are displayed on an absolute scale (from 0 to 100%)...
May 26, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28407167/introduction-of-two-novel-stiffness-parameters-and-interpretation-of-air-puff-induced-biomechanical-deformation-parameters-with-a-dynamic-scheimpflug-analyzer
#5
Cynthia J Roberts, Ashraf M Mahmoud, Jeffrey P Bons, Arif Hossain, Ahmed Elsheikh, Riccardo Vinciguerra, Paolo Vinciguerra, Renato Ambrósio
PURPOSE: To investigate two new stiffness parameters and their relationships with the dynamic corneal response (DCR) parameters and compare normal and keratoconic eyes. METHODS: Stiffness parameters are defined as Resultant Pressure at inward applanation (A1) divided by corneal displacement. Stiffness parameter A1 uses displacement between the undeformed cornea and A1 and stiffness parameter highest concavity (HC) uses displacement from A1 to maximum deflection during HC...
April 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28399067/role-of-the-corneal-epithelium-measurements-in-keratorefractive-surgery
#6
REVIEW
Marcella Q Salomão, Ana Luisa Hofling-Lima, Bernardo T Lopes, Ana Laura C Canedo, Daniel G Dawson, Rui Carneiro-Freitas, Renato Ambrósio
PURPOSE OF REVIEW: Refractive surgery has stimulated considerable progress in corneal and anterior segment imaging, and optical characterization of the eye. From front surface corneal topography, we evolved to three-dimensional corneal tomography with limbus to limbus characterization of the front and back corneal surfaces and pachymetric mapping. Corneal anatomical evaluation has further evolved to layered or segmental tomography with the ability to characterize corneal epithelial thickness profile and the elevation of stromal front surface...
July 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28351945/caveolin-1-mediated-internalization-of-the-vitamin-c-transporter-svct2-in-microglia-triggers-an-inflammatory-phenotype
#7
Camila C Portugal, Renato Socodato, Teresa Canedo, Cátia M Silva, Tânia Martins, Vivian S M Coreixas, Erick C Loiola, Burkhard Gess, Dominik Röhr, Ana R Santiago, Peter Young, Richard D Minshall, Roberto Paes-de-Carvalho, António F Ambrósio, João B Relvas
Vitamin C is essential for the development and function of the central nervous system (CNS). The plasma membrane sodium-vitamin C cotransporter 2 (SVCT2) is the primary mediator of vitamin C uptake in neurons. SVCT2 specifically transports ascorbate, the reduced form of vitamin C, which acts as a reducing agent. We demonstrated that ascorbate uptake through SVCT2 was critical for the homeostasis of microglia, the resident myeloid cells of the CNS that are essential for proper functioning of the nervous tissue...
March 28, 2017: Science Signaling
https://www.readbyqxmd.com/read/28192585/correlations-of-objective-metrics-for-quantifying-dysfunctional-lens-syndrome-with-visual-acuity-and-phacodynamics
#8
Fernando Faria-Correia, Isaac Ramos, Bernardo Lopes, Tiago Monteiro, Nuno Franqueira, Renato Ambrósio
PURPOSE: To study the relationship between objective metrics for quantifying crystalline lens dysfunction with visual impairment and phacodynamics parameters in age-related nuclear cataracts. METHODS: A total of 51 eyes (34 patients) with age-related nuclear cataract had phacoemulsification. The Dysfunctional Lens Index (0 to 10 points) was measured by a ray-tracing aberrometry (iTrace Visual Function Analyzer; Tracey Technologies, Houston, TX). The average lens density (0 to 100) was evaluated using a rotating Scheimpflug system (Pentacam HR; Oculus Optikgeräte GmbH, Wetzlar, Germany), and the nuclear opalescence score was subjectively assessed using the Lens Opacities Classification System III (LOCS III)...
February 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27930790/detection-of-keratoconus-with-a-new-biomechanical-index
#9
Riccardo Vinciguerra, Renato Ambrósio, Ahmed Elsheikh, Cynthia J Roberts, Bernardo Lopes, Emanuela Morenghi, Claudio Azzolini, Paolo Vinciguerra
PURPOSE: To evaluate the ability of a new combined biomechanical index called the Corvis Biomechanical Index (CBI) based on corneal thickness profile and deformation parameters to separate normal from keratoconic patients. METHODS: Six hundred fifty-eight patients (329 eyes in each database) were included in this multicenter retrospective study. Patients from two clinics located on different continents were selected to test the capability of the CBI to separate healthy and keratoconic eyes in more than one ethnic group using the Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany)...
December 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27626155/differentiation-of-mild-keratoconus-from-corneal-warpage-according-to-topographic-inferior-steepening-based-on-corneal-tomography-data
#10
Lia Florim Patrão, Ana Laura Caiado Canedo, João Luiz Peixoto Braga de Azevedo, Rosane Correa, Renato Ambrósio
We report two cases of suspicious asymmetric bow tie and inferior steepening on topographic evaluations with reflection (Placido) and projection (Scheimpflug). Rotating Scheimpflug corneal and anterior segment tomography (Oculus Pentacam HR, Wetzlar, Germany)® was performed in the first case, with a maximal keratometric value (Kmax) of 43.2 D and an overall deviation value from the Belin/Ambrósio Enhanced Ectasia Display (BAD-D) of 1.76, which was observed in the study eye (OD). BAD-D was 6.59 in the fellow eye, which had clinical findings that were consistent with keratoconus stage 2...
July 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27579450/corneal-biomechanics-where-are-we
#11
Allan Luz, Fernando Faria-Correia, Marcela Q Salomão, Bernardo T Lopes, Renato Ambrósio
No abstract text is available yet for this article.
September 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27505316/influence-of-pachymetry-and-intraocular-pressure-on-dynamic-corneal-response-parameters-in-healthy-patients
#12
MULTICENTER STUDY
Riccardo Vinciguerra, Ahmed Elsheikh, Cynthia J Roberts, Renato Ambrósio, David Sung Yong Kang, Bernardo T Lopes, Emanuela Morenghi, Claudio Azzolini, Paolo Vinciguerra
PURPOSE: To evaluate the influence of pachymetry, age, and intraocular pressure in normal patients and to provide normative values for all dynamic corneal response parameters (DCRs) provided by dynamic Scheimpflug analysis. METHODS: Seven hundred five healthy patients were included in this multicenter retrospective study. The biomechanical response data were analyzed to obtain normative values with their dependence on corrected and clinically validated intraocular pressure estimates developed using the finite element method (bIOP), central corneal thickness (CCT), and age, and to evaluate the influence of bIOP, CCT, and age...
August 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27450131/copaifera-duckei-oleoresin-and-its-main-nonvolatile-terpenes-in-vitro-schistosomicidal-properties
#13
Carly H G Borges, Michele G Cruz, Luiza J Carneiro, Jonas J M da Silva, Jairo K Bastos, Denise C Tavares, Pollyanna F de Oliveira, Vanderlei Rodrigues, Rodrigo C S Veneziani, Renato L T Parreira, Giovanni F Caramori, Gláucio R Nagurniak, Lizandra G Magalhães, Sérgio R Ambrósio
In this article, the in vitro schistosomicidal effects of three Brazilian Copaifera oleoresins (C. duckei, C. langsdorffii, and C. reticulata) are reported. From these botanical sources, the oleoresin of C. duckei (OCd) demonstrated to be the most promising, displaying LC50 values of 75.8, 50.6, and 47.2 μg/ml at 24, 48, and 72 h of incubation, respectively, against adult worms of Schistosoma mansoni, with a selectivity index of 10.26. Therefore, the major compounds from OCd were isolated, and the diterpene, (-)-polyalthic acid (PA), showed to be active (LC50 values of 41...
October 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27437883/association-between-sitagliptin-use-and-heart-failure-hospitalization-and-related-outcomes-in-type-2-diabetes-mellitus-secondary-analysis-of-a-randomized-clinical-trial
#14
Darren K McGuire, Frans Van de Werf, Paul W Armstrong, Eberhard Standl, Joerg Koglin, Jennifer B Green, M Angelyn Bethel, Jan H Cornel, Renato D Lopes, Sigrun Halvorsen, Giuseppe Ambrosio, John B Buse, Robert G Josse, John M Lachin, Michael J Pencina, Jyotsna Garg, Yuliya Lokhnygina, Rury R Holman, Eric D Peterson
IMPORTANCE: Previous trial results have suggested that dipeptidyl peptidase 4 inhibitor (DPP4i) use might increase heart failure (HF) risk in type 2 diabetes mellitus (T2DM). The DPP4i sitagliptin has been shown to be noninferior to placebo with regard to primary and secondary composite atherosclerotic cardiovascular (CV) outcomes in the Trial Evaluating Cardiovascular Outcomes With Sitagliptin (TECOS). OBJECTIVE: To assess the association of sitagliptin use with hospitalization for HF (hHF) and related outcomes...
May 1, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27400080/enhanced-combined-tomography-and-biomechanics-data-for-distinguishing-forme-fruste-keratoconus
#15
Allan Luz, Bernardo Lopes, Katie M Hallahan, Bruno Valbon, Isaac Ramos, Fernando Faria-Correia, Paulo Schor, William J Dupps, Renato Ambrósio
PURPOSE: To evaluate the performance of the Ocular Response Analyzer (ORA) (Reichert Ophthalmic Instruments, Depew, NY) variables and Pentacam HR (Oculus Optikgeräte GmbH, Wetzlar, Germany) tomographic parameters in differentiating forme fruste keratoconus (FFKC) from normal corneas, and to assess a combined biomechanical and tomographic parameter to improve outcomes. METHODS: Seventy-six eyes of 76 normal patients and 21 eyes of 21 patients with FFKC were included in the study...
July 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27158811/ectasia-detection-by-the-assessment-of-corneal-biomechanics
#16
COMMENT
Renato Ambrósio, Bernardo Lopes, Fernando Faria-Correia, Riccardo Vinciguerra, Paolo Vinciguerra, Ahmed Elsheikh, Cynthia J Roberts
No abstract text is available yet for this article.
July 2016: Cornea
https://www.readbyqxmd.com/read/27130370/astigmatic-vector-analysis-of-posterior-corneal-surface-a-comparison-among-healthy-forme-fruste-and-overt-keratoconic-corneas
#17
Giuliano de Oliveira Freitas, Renato Ambrósio, Isaac Ramos, Bernardo Lopes, Bruno de Freitas Valbon, Cristiane Botteon, Milton Ruiz Alve
PURPOSE: To determine novel diagnostic parameters for keratoconus, and to assess the correlation between anterior and posterior corneal surfaces based on vectorial astigmatism analyses. DESIGN: Retrospective case-control study. METHODS: Six hundred and ninety-eight eyes of 698 patients were enrolled in the study. Healthy corneas, or controls (C, n = 264), were compared to keratoconic corneas, further categorized as forme fruste (FFKc, n = 212) and overt keratoconus (Kc, n = 222)...
July 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27103780/application-of-different-scheimpflug-based-lens-densitometry-methods-in-phacodynamics-prediction
#18
Fernando Faria-Correia, Bernardo T Lopes, Isaac C Ramos, Tiago Monteiro, Nuno Franqueira, Renato Ambrósio
PURPOSE: To evaluate the correlations between preoperative Scheimpflug-based lens densitometry metrics and phacodynamics. METHODS: The Lens Opacities Classification System III (LOCS III) was used to grade nuclear opalescence (NO), along with different methods of lens densitometry evaluation (absolute scale from 0% to 100%): three-dimensional (3D), linear, and region of interest (ROI) modes. Cumulative dissipated energy (CDE) and total ultrasound (US) time were recorded and correlated with the different methods of cataract grading...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27079610/application-of-corneal-tomography-before-keratorefractive-procedure-for-laser-vision-correction
#19
Allan Luz, Bernardo Lopes, Marcela Salomão, Renato Ambrósio
Ectasia after refractive surgery represents a major concern among refractive surgeons. Corneal abnormalities and preexisting corneal ectasia are the most important risk factors. Corneal topography and central corneal thickness are the factors traditionally screening for in refractive surgery candidates. Study of the anterior surface by Placido topography allows for identification of keratoconus before biomicroscopy. However, this is insufficient for the evaluation of pre-operative refractive surgery. There are cases of ectasia after laser in situ keratomilusis (LASIK) without identifiable risk factors such that there is a need to go beyond the corneal surface...
May 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27070231/comparison-of-dysfunctional-lens-index-and-scheimpflug-lens-densitometry-in-the-evaluation-of-age-related-nuclear-cataracts
#20
COMPARATIVE STUDY
Fernando Faria-Correia, Isaac Ramos, Bernardo Lopes, Tiago Monteiro, Nuno Franqueira, Renato Ambrósio
PURPOSE: To describe the Dysfunctional Lens Index (DLI) from ray-tracing aberrometry and to test its correlations with logMAR corrected distance visual acuity (CDVA) and lens grading based on the Lens Opacities Classification System III (LOCS III) and the Scheimpflug-based lens density. METHODS: The DLI was calculated by the i-Trace Visual Functional Analyzer (Tracey Technologies, Houston, TX). Forty eyes of 30 patients with mild to moderate age-related nuclear cataract were included retrospectively...
April 2016: Journal of Refractive Surgery
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