keyword
MENU ▼
Read by QxMD icon Read
search

Rabinowitz

keyword
https://www.readbyqxmd.com/read/27888909/topical-therapies-for-refractory-chronic-rhinosinusitis
#1
REVIEW
Akshay Sanan, Mindy Rabinowitz, Marc Rosen, Gurston Nyquist
Topical therapy has become an important tool in the otolaryngologist's armamentarium for refractory chronic rhinosinusitis (CRS). Daily high-volume sinonasal saline irrigation and standard metered-dose topical nasal steroid therapy are supported by the most evidence. Nonstandard topical sinonasal steroid therapies are a potential option for refractory CRS. Current evidence recommends against the use of topical antifungal therapy and topical antibiotic therapy delivered using spray and nebulized techniques in routine cases of CRS...
February 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/27887833/the-impact-of-pollutants-from-a-major-northern-highway-on-an-adjacent-hardwood-forest
#2
S A Watmough, T Rabinowitz, S Baker
Emissions of pollutants from highways can exert multiple stresses on adjacent ecosystems. In this study air concentrations of NO2 and throughfall deposition of inorganic N (NO3(-) and NH4(+)), SO4(2-), Cl(-), base cations and several metals were measured in all four seasons along a 1.5km hardwood forest gradient extending away from a major highway (Highway 401) in southern Ontario, Canada. Soil and lichen chemistry and herbaceous plant and epiphytic lichen species composition were measured within the hardwood forest to evaluate impacts of these pollutants...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27882354/bcl-2-associated-athanogene-3-protects-the-heart-from-ischemia-reperfusion-injury
#3
Feifei Su, Valerie D Myers, Tijana Knezevic, JuFang Wang, Erhe Gao, Muniswamy Madesh, Farzaneh G Tahrir, Manish K Gupta, Jennifer Gordon, Joseph Rabinowitz, Frederick V Ramsey, Douglas G Tilley, Kamel Khalili, Joseph Y Cheung, Arthur M Feldman
Bcl-2-associated athanogene 3 (BAG3) is an evolutionarily conserved protein expressed at high levels in the heart and the vasculature and in many cancers. While altered BAG3 expression has been associated with cardiac dysfunction, its role in ischemia/reperfusion (I/R) is unknown. To test the hypothesis that BAG3 protects the heart from reperfusion injury, in vivo cardiac function was measured in hearts infected with either recombinant adeno-associated virus serotype 9-expressing (rAAV9-expressing) BAG3 or GFP and subjected to I/R...
November 17, 2016: JCI Insight
https://www.readbyqxmd.com/read/27872824/packed-red-blood-cell-transfusions-as-a-risk-factor-for-parenteral-nutrition-associated-liver-disease-in-premature-infants
#4
Antoni D'Souza, Anushree Algotar, Ling Pan, Steven M Schwarz, William R Treem, Gloria Valencia, Simon S Rabinowitz
AIM: To determine if packed red blood cell transfusions contribute to the development of parenteral nutrition associated liver disease. METHODS: A retrospective chart review of 49 premature infants on parenteral nutrition for > 30 d who received packed red blood cell (PRBC) transfusions was performed. Parenteral nutrition associated liver disease was primarily defined by direct bilirubin (db) > 2.0 mg/dL. A high transfusion cohort was defined as receiving > 75 mL packed red blood cells (the median value)...
November 8, 2016: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/27866836/physiological-suppression-of-lipotoxic-liver-damage%C3%A2-by-complementary-actions-of-hdac3-and%C3%A2-scap-srebp
#5
Romeo Papazyan, Zheng Sun, Yong Hoon Kim, Paul M Titchenell, David A Hill, Wenyun Lu, Manashree Damle, Min Wan, Yuxiang Zhang, Erika R Briggs, Joshua D Rabinowitz, Mitchell A Lazar
Liver fat accumulation precedes non-alcoholic steatohepatitis, an increasing cause of end-stage liver disease. Histone deacetylase 3 (HDAC3) is required for hepatic triglyceride homeostasis, and sterol regulatory element binding protein (SREBP) regulates the lipogenic response to feeding, but the crosstalk between these pathways is unknown. Here we show that inactivation of SREBP by hepatic deletion of SREBP cleavage activating protein (SCAP) abrogates the increase in lipogenesis caused by loss of HDAC3, but fatty acid oxidation remains defective...
November 10, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27824517/a-rare-case-of-orbital-hodgkin-lymphoma-demonstrating-therapeutic-response-to-a-novel-systemic-medication
#6
Brynn N Wajda, Michael P Rabinowitz
Orbital Hodgkin lymphoma is infrequent, representing less than 1% of adult orbital malignancies. It is typically seen in the setting of terminally advanced systemic disease. This case highlights orbital, head, and neck disease in a systemically stable individual treated with the novel anti-CD30 monoclonal antibody brentuximab vedotin.
November 8, 2016: Orbit
https://www.readbyqxmd.com/read/27822726/comparative-validation-of-abdominal-ct-models-that-predict-need-for-surgery-in-adhesion-related-small-bowel-obstruction
#7
Phillip F Yang, Dean P Rabinowitz, Shing W Wong, Maroof A Khan, Robert C Gandy
INTRODUCTION: Adhesion-related small-bowel obstruction (ASBO) can be managed without surgery in selected patients. The aim of this study was to validate three previously published computed tomography (CT) models that predict need for surgery. METHODS: A retrospective study of patients with ASBO admitted to a tertiary referral hospital between November 2009 and April 2015 was conducted. Data on clinical variables were extracted from medical records. CT signs were assessed by a radiologist who was blinded to whether or not the patients required surgery...
November 7, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27810077/chronic-myelogenous-leukemia-with-acquired-t-11-14-q13-q32-ccnd1-igh-a-case-report-and-literature-review
#8
M T Manda-Mapalo, P Khalili, D Quintana, I Rabinowitz, Q Y Zhang
Approximately 5-10% of chronic myeloid leukemia (CML) patients are found to have structural or numerical additional chromosomal abnormality (ACAs) in addition to the characteristic t(9;22)(q34;q11.2) BCR/ABL1 at the time of diagnosis. The prognostic significance of such additional chromosomal abnormalities has been controversial. Translocation t(11;14)(q13;q32) CCND1-IGH is typically associated with mantle cell lymphoma or a subset of plasma cell myeloma and is exceedingly rare in myeloid neoplasm. Here we report a unique case describing a patient found at diagnosis of chronic phase CML to have both the Philadelphia chromosome as well as t(11;14)-a rare cytogenetic combination...
October 2016: Cancer Genetics
https://www.readbyqxmd.com/read/27807211/a-survey-of-veterinary-antimicrobial-prescribing-practices-washington-state-2015
#9
H Fowler, M A Davis, A Perkins, S Trufan, C Joy, M Buswell, T F McElwain, D Moore, R Worhle, P M Rabinowitz
Antimicrobial resistance is a growing global health issue. It is also a recognised problem in veterinary medicine. Between September and December 2015 the authors administered a cross-sectional survey to licensed veterinarians in Washington State to assess factors affecting antimicrobial prescribing practices among veterinarians in Washington State. Two hundred and three veterinarians completed the survey. The majority of respondents (166, 82 per cent) were engaged in small animal or exotic animal practice...
November 2, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27789812/systems-level-analysis-of-mechanisms-regulating-yeast-metabolic-flux
#10
Sean R Hackett, Vito R T Zanotelli, Wenxin Xu, Jonathan Goya, Junyoung O Park, David H Perlman, Patrick A Gibney, David Botstein, John D Storey, Joshua D Rabinowitz
Cellular metabolic fluxes are determined by enzyme activities and metabolite abundances. Biochemical approaches reveal the impact of specific substrates or regulators on enzyme kinetics but do not capture the extent to which metabolite and enzyme concentrations vary across physiological states and, therefore, how cellular reactions are regulated. We measured enzyme and metabolite concentrations and metabolic fluxes across 25 steady-state yeast cultures. We then assessed the extent to which flux can be explained by a Michaelis-Menten relationship between enzyme, substrate, product, and potential regulator concentrations...
October 28, 2016: Science
https://www.readbyqxmd.com/read/27783617/genetic-diversity-and-population-structure-of-mesoamerican-jaguars-panthera-onca-implications-for-conservation-and-management
#11
Claudia Wultsch, Anthony Caragiulo, Isabela Dias-Freedman, Howard Quigley, Salisa Rabinowitz, George Amato
Mesoamerican jaguars (Panthera onca) have been extirpated from over 77% of their historic range, inhabiting fragmented landscapes at potentially reduced population sizes. Maintaining and restoring genetic diversity and connectivity across human-altered landscapes has become a major conservation priority; nonetheless large-scale genetic monitoring of natural populations is rare. This is the first regional conservation genetic study of jaguars to primarily use fecal samples collected in the wild across five Mesoamerican countries: Belize, Costa Rica, Guatemala, Honduras, and Mexico...
2016: PloS One
https://www.readbyqxmd.com/read/27782961/using-the-objective-structured-clinical-exam-osce-to-assess-acgme-competencies-in-pediatric-gastroenterology-fellows
#12
Aliza B Solomon, Rachel Reed, Keith Benkov, Joseph Kingsbery, Sarah S Lusman, Lisa B Malter, Jeremiah Levine, Simon Rabinowitz, Martin Wolff, Sondra Zabar, Elizabeth Weinshel
BACKGROUND: The Accreditation Council for Graduate Medical Education (ACGME) has described six core competencies with which trainees should demonstrate proficiency. Using the Objective Structured Clinical Exam (OSCE), we aimed to assess four of these competencies among Pediatric GI fellows (PG). METHODS: Eight first-year PG's from six medical centers in the New York area participated in a four-station OSCE with trained standardized patient (SP) actors. The cases included an "ED Consult" for lower GI bleeding; "Breaking Bad News" focusing on CF nutritional complications; "Second Opinion" for abdominal pain; "Transition of Care" for inflammatory bowel disease...
October 25, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27777662/rounds-today-a-qualitative-study-of-internal-medicine-and-pediatrics-resident-perceptions
#13
Raphael Rabinowitz, Jeanne Farnan, Oliver Hulland, Lisa Kearns, Michele Long, Bradley Monash, Priti Bhansali, H Barrett Fromme
BACKGROUND : Attending rounds is a key component of patient care and education at teaching hospitals, yet there is an absence of studies addressing trainees' perceptions of rounds. OBJECTIVE : To determine perceptions of pediatrics and internal medicine residents about the current and ideal purposes of inpatient rounds on hospitalist services. METHODS : In this multi-institutional qualitative study, the authors conducted focus groups with a purposive sample of internal medicine and pediatrics residents at 4 teaching hospitals...
October 2016: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/27732838/reversal-of-cytosolic-one-carbon-flux-compensates-for-loss-of-the-mitochondrial-folate-pathway
#14
Gregory S Ducker, Li Chen, Raphael J Morscher, Jonathan M Ghergurovich, Mark Esposito, Xin Teng, Yibin Kang, Joshua D Rabinowitz
No abstract text is available yet for this article.
October 11, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27722758/comparison-of-the-effect-of-epithelial-removal-by-transepithelial-phototherapeutic-keratectomy-or-manual-debridement-on-cross-linking-procedures-for-progressive-keratoconus
#15
Ronald N Gaster, J Ben Margines, David N Gaster, Xiaohui Li, Yaron S Rabinowitz
PURPOSE: To compare the visual, refractive, keratometric, topographic, and pachymetric outcomes of corneal collagen cross-linking (CXL) for progressive keratoconus following epithelial removal by transepithelial phototherapeutic keratectomy (PTK) or manual debridement. METHODS: In this analysis, 339 eyes (78% male, 22% female) that had undergone CXL following manual epithelial debridement (n = 180) or ablation via PTK (n = 159) were evaluated preoperatively and at 6, 12, and 24 months postoperatively for uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), maximum corneal keratometry, pachymetry, and spherical equivalent...
October 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27718379/negative-emotional-reactivity-moderates-the-relations-between-family-cohesion-and-internalizing-and-externalizing-symptoms-in-adolescence
#16
Jill A Rabinowitz, Ijeoma Osigwe, Deborah A G Drabick, Maureen D Reynolds
Lower family cohesion is associated with adolescent internalizing and externalizing problems. However, there are likely individual differences in youth's responses to family processes. For example, adolescents higher in negative emotional reactivity, who often exhibit elevated physiological responsivity to context, may be differentially affected by family cohesion. We explored whether youth's negative emotional reactivity moderated the relation between family cohesion and youth's symptoms and tested whether findings were consistent with the diathesis-stress model or differential susceptibility hypothesis...
December 2016: Journal of Adolescence
https://www.readbyqxmd.com/read/27718022/erratum-to-in-vitro-cultures-of-ectodermal-monolayers-from-the-model-sea-anemone-nematostella-vectensis
#17
Claudette Rabinowitz, Elisabeth Moiseeva, Baruch Rinkevich
No abstract text is available yet for this article.
October 7, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27713395/an-interdigit-signalling-centre-instructs-coordinate-phalanx-joint-formation-governed-by-5-hoxd-gli3-antagonism
#18
Bau-Lin Huang, Anna Trofka, Aki Furusawa, Jacqueline L Norrie, Adam H Rabinowitz, Steven A Vokes, M Mark Taketo, Jozsef Zakany, Susan Mackem
The number of phalanges and joints are key features of digit 'identity' and are central to limb functionality and evolutionary adaptation. Prior chick work indicated that digit phalanges and their associated joints arise in a different manner than the more sparsely jointed long bones, and their identity is regulated by differential signalling from adjacent interdigits. Currently, there is no genetic evidence for this model, and the molecular mechanisms governing digit joint specification remain poorly understood...
October 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/27669143/thrombospondin-expression-in-myofibers-stabilizes-muscle-membranes
#19
Davy Vanhoutte, Tobias G Schips, Jennifer Q Kwong, Jennifer Davis, Andoria Tjondrokoesoemo, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Hong Yi, Quan Q Gao, Joseph E Rabinowitz, Talila Volk, Elizabeth M McNally, Jeffery D Molkentin
Skeletal muscle is highly sensitive to mutations in genes that participate in membrane stability and cellular attachment, which often leads to muscular dystrophy. Here we show that Thrombospondin-4 (Thbs4) regulates skeletal muscle integrity and its susceptibility to muscular dystrophy through organization of membrane attachment complexes. Loss of the Thbs4 gene causes spontaneous dystrophic changes with aging and accelerates disease in 2 mouse models of muscular dystrophy, while overexpression of mouse Thbs4 is protective and mitigates dystrophic disease...
September 26, 2016: ELife
https://www.readbyqxmd.com/read/27660293/restoration-of-hydrogen-sulfide-production-in-diabetic-mice-improves-reparative-function-of-bone-marrow-cells
#20
Zhongjian Cheng, Venkata Naga Srikanth Garikipati, Emily Nickoloff, Chunlin Wang, David J Polhemus, Jibin Zhou, Cynthia Benedict, Mohsin Khan, Suresh K Verma, Joseph E Rabinowitz, David Lefer, Raj Kishore
BACKGROUND: Bone marrow cell (BMC)-based treatment for critical limb ischemia in diabetic patients yielded a modest therapeutic effect resulting from cell dysfunction. Therefore, approaches that improve diabetic stem/progenitor cell functions may provide therapeutic benefits. Here, we tested the hypothesis that restoration of hydrogen sulfide (H2S) production in diabetic BMCs improves their reparative capacities. METHODS: Mouse BMCs were isolated by density-gradient centrifugation...
November 8, 2016: Circulation
keyword
keyword
83793
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"