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https://www.readbyqxmd.com/read/29217001/long-term-safety-and-efficacy-of-platinum%C3%A2-chromium-everolimus-eluting-stents-in-coronary-artery-disease-5-year-results-from-the-platinum-trial
#1
Christopher R Kelly, Paul S Teirstein, Ian T Meredith, Bruno Farah, Christophe L Dubois, Robert L Feldman, Joseph Dens, Nobuhisa Hagiwara, Abram Rabinowitz, Didier Carrié, Vincent Pompili, Alain Bouchard, Shigeru Saito, Dominic J Allocco, Keith D Dawkins, Gregg W Stone
OBJECTIVES: The authors sought to evaluate the final 5-year safety and effectiveness of the platinum-chromium everolimus-eluting stent (PtCr-EES) in the randomized trial, as well as in 2 single-arm substudies that evaluated PtCr-EES in small vessels (diameter <2.5 mm; n = 94) and long lesions (24 to 34 mm; n = 102). BACKGROUND: In the multicenter, randomized PLATINUM (PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions), the PtCr-EES was noninferior to the cobalt-chromium everolimus-eluting stent (CoCr-EES) at 1 year in 1,530 patients undergoing percutaneous coronary intervention...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29216778/costs-and-effectiveness-of-hearing-conservation-programs-at-14%C3%A2-us-metal-manufacturing-facilities
#2
Stephanie K Sayler, Peter M Rabinowitz, Linda F Cantley, Deron Galusha, Richard L Neitzel
OBJECTIVE: This study characterised overall and specific costs associated with hearing conservation programmes (HCPs) at US metal manufacturing sites, and examined the association between these costs and several noise-induced hearing loss (NIHL) outcomes. DESIGN: We interviewed personnel and reviewed records at participating facilities. We also measured noise for comparison to the ten-year average of measurements made by each facility. NIHL outcomes assessed included rates of standard threshold shifts (STS) and high-frequency hearing loss, as well as prevalence of hearing impairment, for each participating facility...
December 7, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/29181513/sensitivity-to-the-deficits-associated-with-traumatic-brain-injury-or-chronic-traumatic-encephalopathy-reply
#3
Amanda R Rabinowitz, Sameer K Deshpande, Dylan S Small
No abstract text is available yet for this article.
November 27, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29180248/transient-monoclonal-gammopathy-induced-by-candida-fungemia
#4
Joanna L Conant, Ian Rabinowitz, Qian-Yun Zhang
A 41-year-old woman was admitted for Candida fungemia. On hospital day 4, a routine complete blood count and peripheral smear showed circulating plasma cells. Initial work up showed an M-component on serum protein electrophoresis with 6% lambda-predominate plasma cells by flow cytometry. The patient was treated with intravenous antifungal therapy. Her six month follow up laboratory evaluation revealed resolution of the M-component and only rare polyclonal plasma cells in peripheral blood by flow cytometry. This case illustrates that transient monoclongal gammopathy can be induced by fungal infection...
November 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/29153836/post-transcriptional-regulation-of-de-novo-lipogenesis-by-mtorc1-s6k1-srpk2-signaling
#5
Gina Lee, Yuxiang Zheng, Sungyun Cho, Cholsoon Jang, Christina England, Jamie M Dempsey, Yonghao Yu, Xiaolei Liu, Long He, Paola M Cavaliere, Andre Chavez, Erik Zhang, Meltem Isik, Anthony Couvillon, Noah E Dephoure, T Keith Blackwell, Jane J Yu, Joshua D Rabinowitz, Lewis C Cantley, John Blenis
mTORC1 is a signal integrator and master regulator of cellular anabolic processes linked to cell growth and survival. Here, we demonstrate that mTORC1 promotes lipid biogenesis via SRPK2, a key regulator of RNA-binding SR proteins. mTORC1-activated S6K1 phosphorylates SRPK2 at Ser494, which primes Ser497 phosphorylation by CK1. These phosphorylation events promote SRPK2 nuclear translocation and phosphorylation of SR proteins. Genome-wide transcriptome analysis reveals that lipid biosynthetic enzymes are among the downstream targets of mTORC1-SRPK2 signaling...
November 14, 2017: Cell
https://www.readbyqxmd.com/read/29128264/coupling-astogenic-aging-in-the-colonial-tunicate-botryllus-schlosseri-with-the-stress-protein-mortalin
#6
Oshrat Ben-Hamo, Amalia Rosner, Claudette Rabinowitz, Matan Oren, Baruch Rinkevich
Botryllus schlosseri, a colonial marine invertebrate, exhibits three generations of short-lived astogenic modules that continuously grow and die throughout the colony's entire lifespan, within week-long repeating budding cycles (blastogenesis), each consisting of four stages (A-D). At stage D, aging is followed by the complete absorption of adult modules (zooids) via a massive apoptotic process. Here we studied in Botryllus the protein mortalin (HSP70s member), a molecule largely known for its association with aging and proliferation...
November 8, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29103236/new-israeli-sonographic-estimated-fetal-weight-growth-curves-as-compared-to-current-birth-weight-growth-curves-on-what-should-diagnosis-of-intrauterine-growth-disorders-be-based
#7
Alon Z Sapir, Izzat Khayyat, Ron Rabinowitz, Arnon Samueloff, Lior Drukker, Hen Y Sela
BACKGROUND: Two types of growth curves are commonly used to diagnose fetal growth disorders: neonatal birth weight (BW) and sonographic estimated fetal weight (EFW). The debate as to which growth curve to use is universal. OBJECTIVES: To establish sonographic EFW growth curves for the Israeli population and to assess whether the use of the BW growth curves currently adapted in Israel leads to under-diagnosis of intrauterine growth disorders. METHODS: Biometric data collected during a 6 year period was analyzed to establish sonographic EFW growth curves between 15-42 weeks of gestation for the Israeli population...
October 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29094910/pet-therapy-helping-patients-cope
#8
Alida Gertz, Peter M Rabinowitz
No abstract text is available yet for this article.
October 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29091976/what-s-the-purpose-of-rounds-a-qualitative-study-examining-the-perceptions-of-faculty-and-students
#9
Oliver Hulland, Jeanne Farnan, Raphael Rabinowitz, Lisa Kearns, Michele Long, Bradley Monash, Priti Bhansali, H Barrett Fromme
BACKGROUND: Rounds are a critical activity on any inpatient service, but there is little literature describing the purpose of rounds from the perspective of faculty and trainees in teaching hospitals. OBJECTIVE: To evaluate and compare the perceptions of pediatric and internal medicine attendings and medical students regarding the purpose of inpatient attending rounds. METHODS: The authors conducted 10 semistructured focus groups with attendings and medical students in the spring of 2014 at 4 teaching hospitals...
November 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29073064/human-shmt-inhibitors-reveal-defective-glycine-import-as-a-targetable-metabolic-vulnerability-of-diffuse-large-b-cell-lymphoma
#10
Gregory S Ducker, Jonathan M Ghergurovich, Nello Mainolfi, Vipin Suri, Stephanie K Jeong, Sophia Hsin-Jung Li, Adam Friedman, Mark G Manfredi, Zemer Gitai, Hahn Kim, Joshua D Rabinowitz
The enzyme serine hydroxymethyltransferse (SHMT) converts serine into glycine and a tetrahydrofolate-bound one-carbon unit. Folate one-carbon units support purine and thymidine synthesis, and thus cell growth. Mammals have both cytosolic SHMT1 and mitochondrial SHMT2, with the mitochondrial isozyme strongly up-regulated in cancer. Here we show genetically that dual SHMT1/2 knockout blocks HCT-116 colon cancer tumor xenograft formation. Building from a pyrazolopyran scaffold that inhibits plant SHMT, we identify small-molecule dual inhibitors of human SHMT1/2 (biochemical IC50 ∼ 10 nM)...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29045397/glucose-feeds-the-tca-cycle-via-circulating-lactate
#11
Sheng Hui, Jonathan M Ghergurovich, Raphael J Morscher, Cholsoon Jang, Xin Teng, Wenyun Lu, Lourdes A Esparza, Tannishtha Reya, Le Zhan, Jessie Yanxiang Guo, Eileen White, Joshua D Rabinowitz
Mammalian tissues are fuelled by circulating nutrients, including glucose, amino acids, and various intermediary metabolites. Under aerobic conditions, glucose is generally assumed to be burned fully by tissues via the tricarboxylic acid cycle (TCA cycle) to carbon dioxide. Alternatively, glucose can be catabolized anaerobically via glycolysis to lactate, which is itself also a potential nutrient for tissues and tumours. The quantitative relevance of circulating lactate or other metabolic intermediates as fuels remains unclear...
November 2, 2017: Nature
https://www.readbyqxmd.com/read/29039997/orbital-t-cell-lymphoma-versus-lupus-panniculitits-a-t-cell-mediated-spectrum-of-orbital-lymphoproliferative-disease
#12
Alison B Huggins, Charles Kim, Michael P Rabinowitz
This is a case description of a single male patient found to have T-cell-mediated inflammation and lymphoproliferation of the orbit. Chronic T-cell-mediated inflammatory disease can pose a diagnostic challenge particularly in its differentiation from a neoplastic process. The histopathology in this case demonstrated features of both lupus erythematosus panniculitis and features of orbital T-cell lymphoma. While both are rare, lupus erythematosus panniculitis of the orbit is even more exceptional; this patient's indolent, chronic relapsing course distinguished itself from the typical aggression of orbital T-cell lymphoma...
October 17, 2017: Orbit
https://www.readbyqxmd.com/read/29032776/neuropsychological-recovery-trajectories-in-moderate-to-severe-traumatic-brain-injury-influence-of-patient-characteristics-and-diffuse-axonal-injury
#13
Amanda R Rabinowitz, Tessa Hart, John Whyte, Junghoon Kim
OBJECTIVES: The goal of the present study was to elucidate the influence of demographic and neuropathological moderators on the longitudinal trajectory neuropsychological functions during the first year after moderate to severe traumatic brain injury (TBI). In addition to examining demographic moderators such as age and education, we included a measure of whole-brain diffuse axonal injury (DAI), and examined measures of processing speed (PS), executive function (EF), and verbal learning (VL) separately...
October 16, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29023285/predictors-of-electroconvulsive-therapy-use-in-a-large-inpatient-psychiatry-population
#14
Julia Knight, Micaela Jantzi, John Hirdes, Terry Rabinowitz
OBJECTIVE: There is limited research on reliable and clinically useful predictors of electroconvulsive therapy (ECT) use. We aimed to examine factors that predict ECT use in an inpatient psychiatric population. DESIGN: Retrospective analysis of provincial database for inpatient psychiatry. METHODS: This study is a retrospective analysis of a provincial database for inpatient psychiatry. The study includes all psychiatric inpatients 18 years or older in Ontario, Canada, assessed with the Resident Assessment Instrument for Mental Health (RAI-MH) within the first 3 days of admission between 2009 and 2014 (n = 153,023)...
October 12, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28994027/management-of-glenoid-bone-loss-with-anterior-shoulder-instability-indications-and-outcomes
#15
REVIEW
Justin Rabinowitz, Richard Friedman, Josef K Eichinger
PURPOSE OF REVIEW: Glenoid Bone Loss is a commonly encountered problem in anterior shoulder instability. In this article, we review current techniques for diagnosis, indications and management of glenoid bone loss. RECENT FINDINGS: Multiple bone grafting techniques are available depending on the glenoid defect size including the coracoid, distal clavicle, iliac crest, and allograft distal tibia. Advancement in imaging methods allows for more accurate quantification of bone loss...
December 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28985698/application-of-real-time-quantitative-pcr-assays-for-detecting-marine-brucella-spp-in-fish
#16
Stephanie A Norman, Martha A Delaney, Katherine H Haman, Austen C Thomas, Jacques Godfroid, Anett K Larsen, Ingebjørg H Nymo, Suelee Robbe-Austerman, Christine Quance, Jack C Rhyan, Dyanna M Lambourn, Steven J Jeffries, Peter Rabinowitz
Brucella ceti and Brucella pinnipedialis have been documented as occurring in marine mammals, and B. ceti has been identified in 3 naturally acquired human cases. Seroconversion and infection patterns in Pacific Northwest harbor seals ( Phoca vitulina richardii) and North Atlantic hooded seals ( Cystophora cristata) indicate post-weaning exposure through prey consumption or lungworm infection, suggesting fish and possibly invertebrates play an epizootiologic role in marine Brucella transmission and possible foodborne risk to humans...
October 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28978515/late-gestation-maternal-dietary-methyl-donor-and-cofactor-supplementation-in-sheep-partially-reverses-protection-against-allergic-sensitization-by-iugr
#17
Amy L Wooldridge, Robert J Bischof, Hong Liu, Gary K Heinemann, Damien S Hunter, Lynne C Giles, Rebecca A Simmons, Yu-Chin Lien, Wenyun Lu, Joshua D Rabinowitz, Karen L Kind, Julie A Owens, Vicki L Clifton, Kathryn L Gatford
Perinatal exposures are associated with altered risks of childhood allergy. Human studies and our previous work suggest restricted growth in utero (IUGR) is protective against allergic disease. The mechanisms are not clearly defined but reduced fetal abundance and altered metabolism of methyl donors are hypothesized as possible underlying mechanisms. We therefore examined whether late gestation maternal dietary methyl donor and co-factor supplementation of the placentally-restricted (PR) sheep pregnancy would reverse allergic protection in progeny...
October 4, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28964990/high-throughput-in-silico-prediction-of-ionization-equilibria-for-pharmacokinetic-modeling
#18
Cory L Strope, Kamel Mansouri, Harvey J Clewell, James R Rabinowitz, Caroline Stevens, John F Wambaugh
Chemical ionization plays an important role in many aspects of pharmacokinetic (PK) processes such as protein binding, tissue partitioning, and apparent volume of distribution at steady state (Vdss). Here, estimates of ionization equilibrium constants (i.e., pKa) were analyzed for 8132 pharmaceuticals and 24,281 other compounds to which humans might be exposed in the environment. Results revealed broad differences in the ionization of pharmaceutical chemicals and chemicals with either near-field (in the home) or far-field sources...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28942964/fine-mapping-and-functional-analysis-reveal-a-role-of-slc22a1-in-acylcarnitine-transport
#19
Hye In Kim, Johannes Raffler, Wenyun Lu, Jung-Jin Lee, Deepti Abbey, Danish Saleheen, Joshua D Rabinowitz, Michael J Bennett, Nicholas J Hand, Christopher Brown, Daniel J Rader
Genome-wide association studies have identified a signal at the SLC22A1 locus for serum acylcarnitines, intermediate metabolites of mitochondrial oxidation whose plasma levels associate with metabolic diseases. Here, we refined the association signal, performed conditional analyses, and examined the linkage structure to find coding variants of SLC22A1 that mediate independent association signals at the locus. We also employed allele-specific expression analysis to find potential regulatory variants of SLC22A1 and demonstrated the effect of one variant on the splicing of SLC22A1...
October 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28940215/occupational-noise-exposure-and-risk-of-hypertension-in-an-industrial-workforce
#20
Baylah Tessier-Sherman, Deron Galusha, Linda F Cantley, Mark R Cullen, Peter M Rabinowitz, Richard L Neitzel
BACKGROUND: Community noise exposure has been shown to increase the risk of hypertension; however, the relationship between occupational noise exposure and hypertension is less clear. METHODS: Using an inception cohort of workers in a specialty metals manufacturing company, we retrospectively assessed occupational noise exposure, hearing acuity, and incident hypertension diagnoses using administrative datasets. Time-weighted average noise exposure levels were assigned to employees based on their job histories...
December 2017: American Journal of Industrial Medicine
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