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https://www.readbyqxmd.com/read/29463734/reply-to-husz%C3%A3-r-the-elastic-weight-consolidation-penalty-is-empirically-valid
#1
James Kirkpatrick, Razvan Pascanu, Neil Rabinowitz, Joel Veness, Guillaume Desjardins, Andrei A Rusu, Kieran Milan, John Quan, Tiago Ramalho, Agnieszka Grabska-Barwinska, Demis Hassabis, Claudia Clopath, Dharshan Kumaran, Raia Hadsell
No abstract text is available yet for this article.
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29444955/common-and-divergent-features-of-galactose-1-phosphate-and-fructose-1-phosphate-toxicity-in-yeast
#2
Patrick A Gibney, Ariel Schieler, Jonathan C Chen, Jessie M Bacha-Hummel, Maxim Botstein, Matthew Volpe, Sanford J Silverman, Yifan Xu, Bryson D Bennett, Joshua D Rabinowitz, David Botstein
Toxicity resulting from accumulation of sugar-phosphate molecules is an evolutionarily conserved phenomenon, observed in multiple bacterial and eukaryotic systems, including a number of human diseases. However, the molecular mechanisms involved in sugar-phosphate toxicity remain unclear. Using the model eukaryote S. cerevisiae , we developed two systems to accumulate human disease-associated sugar-phosphate species. One system utilizes constitutive expression of galactose permease and galactose kinase to accumulate galactose-1-phosphate, while the other system utilizes constitutive expression of a mammalian ketohexokinase gene to accumulate fructose-1-phosphate...
February 14, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29444425/modulation-of-apoptosis-controls-inhibitory-interneuron-number-in-the-cortex
#3
Myrto Denaxa, Guilherme Neves, Adam Rabinowitz, Sarah Kemlo, Petros Liodis, Juan Burrone, Vassilis Pachnis
Cortical networks are composed of excitatory projection neurons and inhibitory interneurons. Finding the right balance between the two is important for controlling overall cortical excitation and network dynamics. However, it is unclear how the correct number of cortical interneurons (CIs) is established in the mammalian forebrain. CIs are generated in excess from basal forebrain progenitors, and their final numbers are adjusted via an intrinsically determined program of apoptosis that takes place during an early postnatal window...
February 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29437491/human-donor-milk-or-formula-a-qualitative-study-of-maternal-perspectives-on-supplementation
#4
Molly R Rabinowitz, Laura R Kair, Heather L Sipsma, Carrie A Phillipi, Ilse A Larson
BACKGROUND: Breastfeeding is fundamental to maternal and child health and is the most cost-effective intervention to reduce child mortality. Pasteurized human donor milk (HDM) is increasingly provided for term newborns requiring temporary supplementation. Few studies examine maternal perspectives on supplementation of term newborns. MATERIALS AND METHODS: We conducted semistructured in-person interviews with mothers of term newborns (n = 24) during postpartum hospitalization...
February 13, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29423909/perinatal-high-fat-diet-and-early-life-methyl-donor-supplementation-alter-one-carbon-metabolism-and-dna-methylation-in-the-brain
#5
S E McKee, S Zhang, L Chen, J D Rabinowitz, T M Reyes
One carbon metabolism is regulated by the availability of nutrients known as methyl donors, and disruption of this pathway can affect multiple physiological systems. DNA methylation, critical for the regulation of gene expression, is linked to one carbon metabolism, and can be altered by perinatal diet. In the current study, dams (n=12/group) were fed HF or standard control (SC) diet through pregnancy and lactation, and male and female offspring were then fed either SC or methyl donor supplemented diet (MDS) between 3 and 6 weeks of age (n=20-26/group)...
February 9, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29420398/sliding-sign-for-intra-abdominal-adhesion-prediction-before-repeat-cesarean-delivery
#6
Lior Drukker, Hen Y Sela, Orna Reichman, Ron Rabinowitz, Arnon Samueloff, Ori Shen
BACKGROUND: The sliding sign (the relative motion between the abdominal and uterine wall as assessed by ultrasonography) may help identify severe intra-abdominal adhesions before repeat cesarean delivery. METHODS: We conducted a prospective observational study of scheduled repeat cesarean deliveries. Using transabdominal ultrasonography, while the parturient breathed deeply, the ultrasonographer recorded a video clip in a sagittal plane lateral to the umbilicus...
February 5, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29414685/the-small-intestine-converts-dietary-fructose-into-glucose-and-organic-acids
#7
Cholsoon Jang, Sheng Hui, Wenyun Lu, Alexis J Cowan, Raphael J Morscher, Gina Lee, Wei Liu, Gregory J Tesz, Morris J Birnbaum, Joshua D Rabinowitz
Excessive consumption of sweets is a risk factor for metabolic syndrome. A major chemical feature of sweets is fructose. Despite strong ties between fructose and disease, the metabolic fate of fructose in mammals remains incompletely understood. Here we use isotope tracing and mass spectrometry to track the fate of glucose and fructose carbons in vivo, finding that dietary fructose is cleared by the small intestine. Clearance requires the fructose-phosphorylating enzyme ketohexokinase. Low doses of fructose are ∼90% cleared by the intestine, with only trace fructose but extensive fructose-derived glucose, lactate, and glycerate found in the portal blood...
February 6, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29407453/the-light-at-the-end-of-the-scope-the-history-of-electro-surgical-instruments-co-and-the-mignon-lamp
#8
Scott Quarrier, Ronald Rabinowitz
No abstract text is available yet for this article.
January 30, 2018: Urology
https://www.readbyqxmd.com/read/29364879/mitochondrial-translation-requires-folate-dependent-trna-methylation
#9
Raphael J Morscher, Gregory S Ducker, Sophia Hsin-Jung Li, Johannes A Mayer, Zemer Gitai, Wolfgang Sperl, Joshua D Rabinowitz
Folates enable the activation and transfer of one-carbon units for the biosynthesis of purines, thymidine and methionine. Antifolates are important immunosuppressive and anticancer agents. In proliferating lymphocytes and human cancers, mitochondrial folate enzymes are particularly strongly upregulated. This in part reflects the need for mitochondria to generate one-carbon units and export them to the cytosol for anabolic metabolism. The full range of uses of folate-bound one-carbon units in the mitochondrial compartment itself, however, has not been thoroughly explored...
January 24, 2018: Nature
https://www.readbyqxmd.com/read/29340723/veno-venous-extracorporeal-membrane-oxygenation-vv-ecmo-for-acute-respiratory-failure-following-injury-outcomes-in-a-high-volume-adult-trauma-center-with-a-dedicated-unit-for-vv-ecmo
#10
Jay Menaker, Ronald B Tesoriero, Ali Tabatabai, Ronald P Rabinowitz, Christopher Cornachione, Terence Lonergan, Katelyn Dolly, Raymond Rector, James V O'Connor, Deborah M Stein, Thomas M Scalea
INTRODUCTION: The use of veno-venous extracorporeal membrane oxygenation (VV ECMO) has increased over the past decade. The purpose of this study was to evaluate outcomes in adult trauma patients requiring VV ECMO. METHODS: Data were collected on adult trauma patients admitted between January 1, 2015, and November 1, 2016. Demographics, injury-specific data, ECMO data, and survival to discharge were recorded. Medians [interquartile range (IQR)] were reported. A p value ≤0...
January 16, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29337136/as-extracellular-glutamine-levels-decline-asparagine-becomes-an-essential-amino-acid
#11
Natalya N Pavlova, Sheng Hui, Jonathan M Ghergurovich, Jing Fan, Andrew M Intlekofer, Richard M White, Joshua D Rabinowitz, Craig B Thompson, Ji Zhang
When mammalian cells are deprived of glutamine, exogenous asparagine rescues cell survival and growth. Here we report that this rescue results from use of asparagine in protein synthesis. All mammalian cell lines tested lacked cytosolic asparaginase activity and could not utilize asparagine to produce other amino acids or biosynthetic intermediates. Instead, most glutamine-deprived cell lines are capable of sufficient glutamine synthesis to maintain essential amino acid uptake and production of glutamine-dependent biosynthetic precursors, with the exception of asparagine...
January 10, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29320278/prioritizing-posttrafficking-care-for-trafficked-individuals
#12
Veronica Ades, Stephanie X Wu, Emily P Rabinowitz, Sonya Chemouni Bach
No abstract text is available yet for this article.
February 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29297911/non-natural-amino-acid-peptide-microarrays-to-discover-ebola-virus-glycoprotein-ligands
#13
Joshua A Rabinowitz, John C Lainson, Stephen Albert Johnston, Chris W Diehnelt
We demonstrate a platform to screen a virus pseudotyped with Ebola virus glycoprotein (GP) against a library of peptides that contain non-natural amino acids to develop GP affinity ligands. This system could be used for rapid development of peptide-based antivirals for other emerging or neglected tropical infectious diseases.
January 3, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29284125/principles-of-systems-biology-no-24
#14
(no author information available yet)
This month: compressed sensing (Cleary/Regev), metabolism (Rabinowitz, Gilmore, Chandrasekaran), microbiology (Coles, Cooper/Hasty), phosphosite stoichiometry by proteomics (Kirschner), interaction networks (Pappu, Tan, Babu/Emili), immunology (Łuksza/Greenbaum), mechanosensitive transcription (Elosegui-Artola/Roca-Cusachs).
December 27, 2017: Cell Systems
https://www.readbyqxmd.com/read/29281826/converging-mechanisms-of-p53-activation-drive-motor-neuron-degeneration-in-spinal-muscular-atrophy
#15
Christian M Simon, Ya Dai, Meaghan Van Alstyne, Charalampia Koutsioumpa, John G Pagiazitis, Joshua I Chalif, Xiaojian Wang, Joseph E Rabinowitz, Christopher E Henderson, Livio Pellizzoni, George Z Mentis
The hallmark of spinal muscular atrophy (SMA), an inherited disease caused by ubiquitous deficiency in the SMN protein, is the selective degeneration of subsets of spinal motor neurons. Here, we show that cell-autonomous activation of p53 occurs in vulnerable but not resistant motor neurons of SMA mice at pre-symptomatic stages. Moreover, pharmacological or genetic inhibition of p53 prevents motor neuron death, demonstrating that induction of p53 signaling drives neurodegeneration. At late disease stages, however, nuclear accumulation of p53 extends to resistant motor neurons and spinal interneurons but is not associated with cell death...
December 26, 2017: Cell Reports
https://www.readbyqxmd.com/read/29261847/tsc1-mutations-in-keratoconus-patients-with-or-without-tuberous-sclerosis
#16
Yelena Bykhovskaya, Majid Fardaei, Mariam Lotfy Khaled, Mahmood Nejabat, Ramin Salouti, Hassan Dastsooz, Yutao Liu, Soroor Inaloo, Yaron S Rabinowitz
Purpose: To test candidate genes TSC1 and TSC2 in a family affected by tuberous sclerosis complex (TSC) where proband was also diagnosed with bilateral keratoconus (KC) and to test the hypothesis that defects in the same gene may lead to a nonsyndromic KC. Methods: Next-generation sequencing of TSC1 and TSC2 genes was performed in a proband affected by TSC and KC. Identified mutation was confirmed by Sanger DNA sequencing. Whole exome sequencing (WES) was performed in patients with nonsyndromic KC...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29260688/geogenomic-segregation-and-temporal-trends-of-human-pathogenic-escherichia-coli-o157-h7-washington-usa-2005-20141
#17
Gillian A M Tarr, Smriti Shringi, Amanda I Phipps, Thomas E Besser, Jonathan Mayer, Hanna N Oltean, Jon Wakefield, Phillip I Tarr, Peter Rabinowitz
The often-noted and persistent increased incidence of Escherichia coli O157:H7 infections in rural areas is not well understood. We used a cohort of E. coli O157:H7 cases reported in Washington, USA, during 2005-2014, along with phylogenomic characterization of the infecting isolates, to identify geographic segregation of and temporal trends in specific phylogenetic lineages of E. coli O157:H7. Kernel estimation and generalized additive models demonstrated that pathogen lineages were spatially segregated during the period of analysis and identified a focus of segregation spanning multiple, predominantly rural, counties for each of the main clinical lineages, Ib, IIa, and IIb...
January 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29258292/corrigendum-phylogenetic-ctdna-analysis-depicts-early-stage-lung-cancer-evolution
#18
Christopher Abbosh, Nicolai J Birkbak, Gareth A Wilson, Mariam Jamal-Hanjani, Tudor Constantin, Raheleh Salari, John Le Quesne, David A Moore, Selvaraju Veeriah, Rachel Rosenthal, Teresa Marafioti, Eser Kirkizlar, Thomas B K Watkins, Nicholas McGranahan, Sophia Ward, Luke Martinson, Joan Riley, Francesco Fraioli, Maise Al Bakir, Eva Grönroos, Francisco Zambrana, Raymondo Endozo, Wenya Linda Bi, Fiona M Fennessy, Nicole Sponer, Diana Johnson, Joanne Laycock, Seema Shafi, Justyna Czyzewska-Khan, Andrew Rowan, Tim Chambers, Nik Matthews, Samra Turajlic, Crispin Hiley, Siow Ming Lee, Martin D Forster, Tanya Ahmad, Mary Falzon, Elaine Borg, David Lawrence, Martin Hayward, Shyam Kolvekar, Nikolaos Panagiotopoulos, Sam M Janes, Ricky Thakrar, Asia Ahmed, Fiona Blackhall, Yvonne Summers, Dina Hafez, Ashwini Naik, Apratim Ganguly, Stephanie Kareht, Rajesh Shah, Leena Joseph, Anne Marie Quinn, Phil A Crosbie, Babu Naidu, Gary Middleton, Gerald Langman, Simon Trotter, Marianne Nicolson, Hardy Remmen, Keith Kerr, Mahendran Chetty, Lesley Gomersall, Dean A Fennell, Apostolos Nakas, Sridhar Rathinam, Girija Anand, Sajid Khan, Peter Russell, Veni Ezhil, Babikir Ismail, Melanie Irvin-Sellers, Vineet Prakash, Jason F Lester, Malgorzata Kornaszewska, Richard Attanoos, Haydn Adams, Helen Davies, Dahmane Oukrif, Ayse U Akarca, John A Hartley, Helen L Lowe, Sara Lock, Natasha Iles, Harriet Bell, Yenting Ngai, Greg Elgar, Zoltan Szallasi, Roland F Schwarz, Javier Herrero, Aengus Stewart, Sergio A Quezada, Karl S Peggs, Peter Van Loo, Caroline Dive, C Jimmy Lin, Matthew Rabinowitz, Hugo J W L Aerts, Allan Hackshaw, Jacqui A Shaw, Bernhard G Zimmermann, Charles Swanton
This corrects the article DOI: 10.1038/nature22364.
December 20, 2017: Nature
https://www.readbyqxmd.com/read/29243104/skepticism-regarding-vaccine-and-gluten-free-food-safety-among-patients-with-celiac-disease-and-non-celiac-gluten-sensitivity
#19
Loren G Rabinowitz, Haley M Zylberberg, Alan Levinovitz, Melissa S Stockwell, Peter H R Green, Benjamin Lebwohl
BACKGROUND: There has been a marked increase in the adoption of the gluten-free (GF) diet. AIMS: To query individuals with celiac disease (CD) and non-celiac gluten sensitivity (NCGS) on their beliefs toward the health effects of gluten, and safety of vaccines and GF food products. METHODS: We distributed a Web-based survey to individuals with CD and NCGS on a CD center e-mail list. We used univariate and multivariate analysis to compare responses of respondents with CD and NCGS...
December 14, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29217001/long-term-safety-and-efficacy-of-platinum%C3%A2-chromium-everolimus-eluting-stents-in-coronary-artery-disease-5-year-results-from-the-platinum-trial
#20
Christopher R Kelly, Paul S Teirstein, Ian T Meredith, Bruno Farah, Christophe L Dubois, Robert L Feldman, Joseph Dens, Nobuhisa Hagiwara, Abram Rabinowitz, Didier Carrié, Vincent Pompili, Alain Bouchard, Shigeru Saito, Dominic J Allocco, Keith D Dawkins, Gregg W Stone
OBJECTIVES: The authors sought to evaluate the final 5-year safety and effectiveness of the platinum-chromium everolimus-eluting stent (PtCr-EES) in the randomized trial, as well as in 2 single-arm substudies that evaluated PtCr-EES in small vessels (diameter <2.5 mm; n = 94) and long lesions (24 to 34 mm; n = 102). BACKGROUND: In the multicenter, randomized PLATINUM (PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions), the PtCr-EES was noninferior to the cobalt-chromium everolimus-eluting stent (CoCr-EES) at 1 year in 1,530 patients undergoing percutaneous coronary intervention...
December 11, 2017: JACC. Cardiovascular Interventions
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