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stool bank

Anne A Rode, Mahtab Chehri, Andreas Munk Petersen, Peter Bytzer
Faecal microbiota transplantation (FMT) is the transferral of faeces from a healthy donor to a patient with a disease linked to disturbances in the gut microbiota. The treatment has been implemented at several hospitals in Denmark, and banks with frozen donor stool material have been established. The effect of FMT for recurrent Clostridium difficile infection is well-documented. FMT cannot be recommended for routine clinical use for inflammatory bowel disease and irritable bowel syndrome because of lack of data from clinical trials...
July 31, 2017: Ugeskrift for Laeger
Bakary Sanneh, Ebrima Joof, Abdoulie M Sanyang, Kristen Renneker, Yaya Camara, Alhagie Papa Sey, Sheriffo Jagne, Ignatius Baldeh, Serign Jawo Ceesay, Sana M Sambou, Kisito Ogoussan
BACKGROUND: Studies in Sub Saharan Africa have shown that the Circulating Cathodic Antigen point-of-care-test (POC-CCA) is more accurate in the detections of S. mansoni than the microscopic Kato-Katz technique but less is known about the accuracy of this rapid test in detecting S. haematobium infections. This study was intended to evaluate the field accuracy of POC-CCA as a rapid test kit for schistosomiasis mapping in The Gambia. METHODS: This prospective study was conducted in 4 regions in the country...
2017: PloS One
E M Terveer, Y H van Beurden, A Goorhuis, J F M L Seegers, M P Bauer, E van Nood, M G W Dijkgraaf, C J J Mulder, C M J E Vandenbroucke-Grauls, H W Verspaget, J J Keller, E J Kuijper
BACKGROUND: Since 2013, several stool banks have been developed following publications reporting on clinical success of 'faecal microbiota transplantation' (FMT) for recurrent Clostridium difficile infections (CDI). However, protocols for donor screening, faecal suspension preparation, and transfer of the faecal suspension differ between countries and institutions. Moreover, no European consensus exists regarding the legislative aspects of the faecal suspension product. Internationally standardized recommendations about the above mentioned aspects have not yet been established...
May 19, 2017: Clinical Microbiology and Infection
Sally Alrabaa, Ripal Jariwala, Kristen Zeitler, Jose Montero
BACKGROUND: Clostridium difficile infection (CDI) is a major infectious disease focus for which fecal microbiota transplantation (FMT) has been used with success in various patient populations. METHODS: We conducted a retrospective study of FMT in immunocompetent and immunocompromised patients to review outcomes at our center, with a focus on identifying risk factors for FMT failure in solid organ transplant (SOT) patients. FMT was conducted using universal banked frozen stool via naso-duodenal tube in patients with recurrent CDI of 3 or more episodes per our institutional protocol...
August 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Tina Amirtha
No abstract text is available yet for this article.
June 10, 2016: Science
Samuel P Costello, Emily C Tucker, Justin La Brooy, Mark N Schoeman, Jane M Andrews
Recurrent or refractory Clostridium difficile infection (CDI) has become an increasing problem in the past decade. Fecal microbiota transplant (FMT) is a highly efficacious treatment for recurrent CDI; however, a number of technical, logistical, and regulatory issues have hampered the development of an FMT capability at many hospitals. The development of a frozen stool bank of screened donor stool is an important step in the standardization of the procedure. This gives clinicians rapid access to thoroughly screened donor stool when needed, without the ethical and logistical problems associated with patient-selected donors...
April 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Eloísa Tedeschi Dauar, Giuseppina Maria Patavino, Alfredo Mendrone Júnior, Sandra Fátima Menosi Gualandro, Ester Cerdeira Sabino, Cesar de Almeida-Neto
OBJECTIVE: Deferral of blood donors due to low hematocrit and iron depletion is commonly reported in blood banks worldwide. This study evaluated the risk factors for low hematocrit and iron depletion among prospective blood donors in a large Brazilian blood center. METHOD: A case-control study of 400 deferred donors due to low hematocrit and 456 eligible whole blood donors was conducted between 2009 and 2011. Participants were interviewed about selected risk factors for anemia, and additional laboratory tests, including serum ferritin, were performed...
September 2015: Revista Brasileira de Hematologia e Hemoterapia
S P Costello, M A Conlon, M S Vuaran, I C Roberts-Thomson, J M Andrews
BACKGROUND: Faecal microbial transplant (FMT) for recurrent Clostridium difficile infection (rCDI) is greatly facilitated by frozen stool banks. However, the effect of frozen storage of stool for greater than 2 months on the viability of stool bacteria is unknown and the efficacy of FMT is not clear. AIM: To evaluate the viability of bacteria in stool frozen for up to 6 months, and the clinical efficacy of FMT with stool frozen for 2-10 months, for the treatment of rCDI...
October 2015: Alimentary Pharmacology & Therapeutics
Wai K Leung
With the incidence of inflammatory bowel disease (IBD) increasing rapidly in many Asian countries, including Hong Kong, it is important that patient characteristics are better understood. For example, are the phenotypes, behaviors, complications, and even treatment responses found in Asian patients similar to those of their Western counterparts? To formally address these questions, a properly designed local cohort study is needed. Whilst IBD is still relatively uncommon in Asia, the establishment of a local IBD registry will significantly contribute to the answering of these questions...
July 2015: Intestinal Research
Sudarshan Paramsothy, Thomas J Borody, Enmoore Lin, Sarah Finlayson, Alissa J Walsh, Douglas Samuel, Johan van den Bogaerde, Rupert W L Leong, Susan Connor, Watson Ng, Hazel M Mitchell, Nadeem Kaakoush, Michael A Kamm
BACKGROUND: Increasing demand for fecal microbiota transplantation (FMT) has created a need for stool banks sourced from long-term healthy donors. Here, we describe our experience in recruiting and screening fecal donors. METHODS: Mailbox, newspaper, and online advertisements were used. Potential donors were required to satisfy a prescreen telephone conversation, pass blood and stool investigations, then undertake a screening interview including medical history, physical examination, and evaluation of donor selection criteria...
July 2015: Inflammatory Bowel Diseases
Nitsan Maharshak
The enteric microbial population (microbiota) has a tremendous impact on our health and multiple disease states are associated with an alteration of the enteric microbial profile. It has been suggested that fecal microbial transplantation (FMT)--a transfer of fecal microbiota from a healthy donor to a sick person, may be beneficial for the treatment of certain diseases such as obesity, diabetes and inflammatory bowel diseases. Currently, this treatment has been approved in Israel, as well as in other countries, for the treatment of recurrent Clostridium difficile infection (RCDI)...
March 2015: Harefuah
Salman Khan, Priti Singh, Asnish Asthana, Mukhtar Ansari
BACKGROUND AND OBJECTIVES: Shigella plays an important role as a causative organism of acute gastroenteritis, in children and others. Rapid emergence of antibiotic resistance warrants continuous monitoring of susceptibility pattern of bacterial isolates. We report here our findings about Shigella spp. isolates and their drug resistance patterns in Nepalese patients. MATERIALS AND METHODS: The study was conducted on 507 Nepalese patients with acute gastroenteritis attending outpatient and inpatient departments of Nepalgunj Medical college and teaching Hospital, Banke, Nepal from September 2011 to April 2013...
December 2013: Iranian Journal of Microbiology
Armelle Forrer, Penelope Vounatsou, Somphou Sayasone, Youthanavanh Vonghachack, Dalouny Bouakhasith, Jürg Utzinger, Kongsap Akkhavong, Peter Odermatt
BACKGROUND: Among the common soil-transmitted helminth infections, hookworm causes the highest burden. Previous research in the southern part of Lao People's Democratic Republic (Lao PDR) revealed high prevalence rates of hookworm infection. The purpose of this study was to predict the spatial distribution of hookworm infection and intensity, and to investigate risk factors in the Champasack province, southern Lao PDR. METHODOLOGY: A cross-sectional parasitological and questionnaire survey was conducted in 51 villages...
March 2015: PLoS Neglected Tropical Diseases
Marianne Pavel, Dieter Hörsch, Martyn Caplin, John Ramage, Thomas Seufferlein, Juan Valle, Phillip Banks, Pablo Lapuerta, Arthur Sands, Brian Zambrowicz, Douglas Fleming, Bertram Wiedenmann
CONTEXT: Carcinoid syndrome (CS) is associated with elevated serotonin, diarrhea, flushing, and increased risk of valvular heart disease. Many patients respond to somatostatin analogs initially, but response diminishes in most patients. Additional options are needed. OBJECTIVE: To assess whether telotristat etiprate (TE) can reduce gastrointestinal symptoms in CS and reduce urinary 5-hydroxyindoleacetic acid (u5-HIAA; a biomarker of serotonin). DESIGN: A prospective, exploratory, dose-escalating 12-week, open-label, multicenter study of TE with efficacy and safety analyses...
April 2015: Journal of Clinical Endocrinology and Metabolism
Qingjun Kao, Zhou Sun, Li Xie, Xiaoying Pu, Xuhui Yang, Renjie Huang
OBJECTIVE: To comprehend the epidemiologic of hepatitis E and genetic characteristics of hepatitis E virus (HEV) in Hangzhou from 2004 to 2011. METHODS: Using China information system for disease control and prevention, the incidence of hepatitis E from 2004 to 2011 in Hangzhou city, and the basic information of patients were collected. In 2011, 65 hepatitis E laboratory confirmed cases were selected by random number table sampling method from the hospitals designated infectious diseases in Hangzhou city, and acquisition of the 60 blood specimens and stool specimens of 18 copies...
September 2014: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Millie D Long, R Jean Cadigan, Suzanne F Cook, Kaaren Haldeman, Kriste Kuczynski, Robert S Sandler, Christopher F Martin, Wenli Chen, Michael D Kappelman
BACKGROUND: Little is known about beliefs, understanding, and perceptions of biobanking among patients with inflammatory bowel diseases. We aimed to further understand perceptions of biobanking in the inflammatory bowel disease community. METHODS: Subjects were recruited to participate in a 1:1 telephone interview on their perceptions of the risks and benefits of contributing specimens for research. These interviews informed a survey instrument evaluating perceptions of biobanking within Crohn's and Colitis Foundation of America Partners cohort...
January 2015: Inflammatory Bowel Diseases
Jung Sook Yeom, Young-Soo Kim, Ji-Hyun Seo, Ji Sook Park, Eun Sil Park, Jae-Young Lim, Hyang-Ok Woo, Hee-Shang Youn, Dae Seob Choi, Ju-Young Chung, Tae-Hee Han, Chan-Hoo Park
OBJECTIVE: To report a consecutive series of neonates with seizures or apnea and displaying white matter injuries with distinctive magnetic resonance diffusion-weighted imaging (DWI) pattern, and to discuss the high positive rate of rotavirus infection seen in these patients. METHODS: In a retrospective review of neonates who were admitted to a tertiary referral center with seizures or apnea, we found a distinctive pattern of white matter injury (symmetrical restricted diffusion in the periventricular white matter and white matter tracts including the corpus callosum) in 18 patients...
January 6, 2015: Neurology
Govert J van Dam, Peter Odermatt, Luz Acosta, Robert Bergquist, Claudia J de Dood, Dieuwke Kornelis, Sinuon Muth, Jürg Utzinger, Paul L A M Corstjens
In Asia, Schistosoma japonicum is the predominant schistosome species, while Schistosoma mekongi is confined to limited foci in Cambodia and Lao People's Democratic Republic. While the People's Republic of China has been successful in controlling schistosomiasis, the disease remains a major public health issue in other areas. In order to prioritise intervention areas, not only accurate diagnosis is important but also other factors, such as practicality, time-efficiency and cost-effectiveness, since they strongly influence the success of control programmes...
January 2015: Acta Tropica
Sumeet R Patil, Benjamin F Arnold, Alicia L Salvatore, Bertha Briceno, Sandipan Ganguly, John M Colford, Paul J Gertler
BACKGROUND: Poor sanitation is thought to be a major cause of enteric infections among young children. However, there are no previously published randomized trials to measure the health impacts of large-scale sanitation programs. India's Total Sanitation Campaign (TSC) is one such program that seeks to end the practice of open defecation by changing social norms and behaviors, and providing technical support and financial subsidies. The objective of this study was to measure the effect of the TSC implemented with capacity building support from the World Bank's Water and Sanitation Program in Madhya Pradesh on availability of individual household latrines (IHLs), defecation behaviors, and child health (diarrhea, highly credible gastrointestinal illness [HCGI], parasitic infections, anemia, growth)...
August 2014: PLoS Medicine
Damodar Paudel, Myo Nyein Aung, Bindhya Sharma, Thin Nyein Nyein Aung, Saiyud Moolphate
OBJECTIVE: To find out the scenario of intestinal parasitic infestation in combatants and their families in the setting of Mid-Western Regional Police Hospital (MWRPH), Nepal. STUDY DESIGN: Cross-sectional study. METHODS: All 2005 patients presented with the complaint of abdominal pain, diarrhoea, frequent defecation, blood in stool, or black stool from August 2007 to February 2011 were offered a stool examination. About 10g of fresh stool was collected in a clean, dry bottle...
May 2014: Global Journal of Health Science
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